OR51I1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole assembly (GO:0098534)9.75342534
2keratinocyte proliferation (GO:0043616)6.63026479
3nuclear pore complex assembly (GO:0051292)6.33459478
4* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)6.01270008
5replicative senescence (GO:0090399)5.97686958
6* sensory perception of smell (GO:0007608)5.91463427
7nuclear pore organization (GO:0006999)5.27629887
8protein K6-linked ubiquitination (GO:0085020)4.88960570
9histone H3-K9 methylation (GO:0051567)4.63573576
10peptidyl-threonine dephosphorylation (GO:0035970)4.61701913
11pore complex assembly (GO:0046931)4.56573824
12regulation of centriole replication (GO:0046599)4.54831244
13mitotic sister chromatid cohesion (GO:0007064)4.35644797
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.99933631
15DNA replication checkpoint (GO:0000076)3.89512758
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.85528058
17* detection of chemical stimulus involved in sensory perception (GO:0050907)3.84777992
18regulation of translational fidelity (GO:0006450)3.80669058
19pseudouridine synthesis (GO:0001522)3.79937645
20protein localization to chromosome, centromeric region (GO:0071459)3.78060631
21microtubule depolymerization (GO:0007019)3.74548891
22rRNA catabolic process (GO:0016075)3.73304832
23DNA replication-dependent nucleosome organization (GO:0034723)3.72939021
24DNA replication-dependent nucleosome assembly (GO:0006335)3.72939021
25centrosome duplication (GO:0051298)3.71311623
26peptidyl-histidine modification (GO:0018202)3.68632637
27response to UV-C (GO:0010225)3.67034335
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.66771205
29DNA replication initiation (GO:0006270)3.62741521
30regulation of mitotic spindle organization (GO:0060236)3.59846884
31histone H3-K9 modification (GO:0061647)3.58314119
32folic acid-containing compound biosynthetic process (GO:0009396)3.55093736
33mitotic nuclear envelope disassembly (GO:0007077)3.54813922
34regulation of centrosome cycle (GO:0046605)3.53247394
35DNA topological change (GO:0006265)3.49153041
36double-strand break repair via homologous recombination (GO:0000724)3.49093576
37recombinational repair (GO:0000725)3.47034478
38telomere maintenance via semi-conservative replication (GO:0032201)3.47028709
39meiotic chromosome segregation (GO:0045132)3.44853549
40positive regulation of histone H3-K4 methylation (GO:0051571)3.43569261
41heterochromatin organization (GO:0070828)3.43018034
42oocyte maturation (GO:0001556)3.42170628
43regulation of centrosome duplication (GO:0010824)3.40162475
44intra-S DNA damage checkpoint (GO:0031573)3.39965262
45interkinetic nuclear migration (GO:0022027)3.34960375
46DNA-dependent DNA replication (GO:0006261)3.34292872
47embryonic process involved in female pregnancy (GO:0060136)3.32434397
48regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.30705167
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.29656884
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29656884
51protein localization to kinetochore (GO:0034501)3.28233294
52telomere maintenance via telomerase (GO:0007004)3.28121923
53membrane disassembly (GO:0030397)3.23487815
54nuclear envelope disassembly (GO:0051081)3.23487815
55rRNA methylation (GO:0031167)3.19894604
56DNA strand elongation involved in DNA replication (GO:0006271)3.18830694
57chromatin remodeling at centromere (GO:0031055)3.18086890
58mitochondrial DNA replication (GO:0006264)3.17815095
59inositol phosphate dephosphorylation (GO:0046855)3.17784640
60phosphorylated carbohydrate dephosphorylation (GO:0046838)3.17784640
61apoptotic DNA fragmentation (GO:0006309)3.16215940
62DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16018980
63mitotic recombination (GO:0006312)3.15945145
64synapsis (GO:0007129)3.15513241
65sister chromatid cohesion (GO:0007062)3.14483983
66amino acid activation (GO:0043038)3.12757856
67tRNA aminoacylation (GO:0043039)3.12757856
68DNA strand elongation (GO:0022616)3.09808115
69acrosome assembly (GO:0001675)3.08984614
70regulation of acyl-CoA biosynthetic process (GO:0050812)3.07802212
71N-terminal protein amino acid modification (GO:0031365)3.05973715
72male meiosis I (GO:0007141)3.04490249
73mitotic spindle checkpoint (GO:0071174)3.03602794
74regulation of translational termination (GO:0006449)3.03049485
75protein localization to chromosome (GO:0034502)3.02445319
76telomere maintenance via recombination (GO:0000722)3.01388428
77centriole replication (GO:0007099)3.00971162
78mitotic metaphase plate congression (GO:0007080)3.00651874
79transcription from mitochondrial promoter (GO:0006390)2.99612424
80DNA catabolic process, exonucleolytic (GO:0000738)2.99076643
81inositol phosphate catabolic process (GO:0071545)2.98994889
82* sensory perception of chemical stimulus (GO:0007606)2.94894228
83mitotic sister chromatid segregation (GO:0000070)2.93285126
84resolution of meiotic recombination intermediates (GO:0000712)2.92884943
85negative regulation of smooth muscle cell differentiation (GO:0051151)2.92396407
86mitotic spindle assembly checkpoint (GO:0007094)2.91209194
87nucleotide-excision repair, DNA gap filling (GO:0006297)2.90513546
88spindle assembly checkpoint (GO:0071173)2.88994824
89sister chromatid segregation (GO:0000819)2.88590858
90DNA damage response, signal transduction resulting in transcription (GO:0042772)2.88546586
91mitotic chromosome condensation (GO:0007076)2.85240493
92dosage compensation (GO:0007549)2.85177135
93positive regulation of glycoprotein biosynthetic process (GO:0010560)2.84754887
94inner cell mass cell proliferation (GO:0001833)2.84177024
95telomere maintenance via telomere lengthening (GO:0010833)2.82762003
96rRNA modification (GO:0000154)2.81509848
97negative regulation of sister chromatid segregation (GO:0033046)2.81151771
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81151771
99negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81151771
100motile cilium assembly (GO:0044458)14.1562244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.68232254
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.65844673
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.22953391
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52029088
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.46550236
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92654012
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81702294
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60116322
9VDR_22108803_ChIP-Seq_LS180_Human2.46223695
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40530637
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39194839
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38297531
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.36968541
14EWS_26573619_Chip-Seq_HEK293_Human2.35083190
15ELK1_19687146_ChIP-ChIP_HELA_Human2.24531677
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.17510489
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.16735683
18GATA1_22025678_ChIP-Seq_K562_Human2.14443406
19AR_21909140_ChIP-Seq_LNCAP_Human2.08751723
20VDR_23849224_ChIP-Seq_CD4+_Human2.03713491
21E2F7_22180533_ChIP-Seq_HELA_Human11.0129062
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.99900977
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99224511
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.95386969
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94566206
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92183858
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89844379
28DCP1A_22483619_ChIP-Seq_HELA_Human1.89838921
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89785071
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84546594
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84245545
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81500874
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79011211
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78397054
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75135164
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70746178
37TTF2_22483619_ChIP-Seq_HELA_Human1.66040535
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66002656
39FOXP3_21729870_ChIP-Seq_TREG_Human1.61844178
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49757881
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47764818
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42163823
43XRN2_22483619_ChIP-Seq_HELA_Human1.41388992
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38402651
45FUS_26573619_Chip-Seq_HEK293_Human1.31586144
46MYC_18940864_ChIP-ChIP_HL60_Human1.30033654
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29733263
48KDM5A_27292631_Chip-Seq_BREAST_Human1.25851134
49GABP_19822575_ChIP-Seq_HepG2_Human1.25747787
50E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24955305
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24732027
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24696224
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24078222
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.13877681
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13358075
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.13254534
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10764903
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.07522691
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07040522
60ER_23166858_ChIP-Seq_MCF-7_Human1.06341708
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03607063
62REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01010098
63ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99026441
64ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98422415
65ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97496665
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96554435
67FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94540340
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88257051
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86028831
70TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85762059
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85062807
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84167494
73PHF8_20622853_ChIP-Seq_HELA_Human0.83982314
74NFYB_21822215_ChIP-Seq_K562_Human0.83885521
75TP53_16413492_ChIP-PET_HCT116_Human0.83261077
76NCOR1_26117541_ChIP-Seq_K562_Human0.82996415
77FLI1_27457419_Chip-Seq_LIVER_Mouse0.82678318
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81263567
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80977940
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79777757
81ELF5_23300383_ChIP-Seq_T47D_Human0.78548967
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77876893
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75943346
84TP53_22573176_ChIP-Seq_HFKS_Human0.74850703
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.74848298
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74057516
87NFYA_21822215_ChIP-Seq_K562_Human0.69752432
88ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69122937
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68851484
90HNFA_21074721_ChIP-Seq_CACO-2_Human0.68149969
91TBL1_22424771_ChIP-Seq_293T_Human0.67089646
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.66165543
93GATA1_19941826_ChIP-Seq_K562_Human0.65188294
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.64966062
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.64932321
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.64856144
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.64599885
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.63857008
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.63725008
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.63089355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.62759090
2MP0000569_abnormal_digit_pigmentation4.51965736
3MP0009697_abnormal_copulation4.10241090
4MP0003111_abnormal_nucleus_morphology3.94087023
5MP0002396_abnormal_hematopoietic_system3.93871761
6MP0008058_abnormal_DNA_repair3.83783146
7MP0005451_abnormal_body_composition3.59504361
8MP0010307_abnormal_tumor_latency3.35966848
9MP0003786_premature_aging3.04297206
10MP0008007_abnormal_cellular_replicative2.97839914
11MP0003123_paternal_imprinting2.90366905
12MP0004957_abnormal_blastocyst_morpholog2.86286368
13MP0003077_abnormal_cell_cycle2.77376319
14MP0003693_abnormal_embryo_hatching2.35507322
15MP0000427_abnormal_hair_cycle2.24349484
16MP0004147_increased_porphyrin_level2.04375293
17MP0008057_abnormal_DNA_replication1.96443277
18MP0000678_abnormal_parathyroid_gland1.94965534
19MP0008932_abnormal_embryonic_tissue1.90508832
20MP0006035_abnormal_mitochondrial_morpho1.83665893
21MP0006036_abnormal_mitochondrial_physio1.74634514
22MP0005646_abnormal_pituitary_gland1.74391726
23MP0002160_abnormal_reproductive_system1.69284117
24MP0002009_preneoplasia1.64437973
25MP0003806_abnormal_nucleotide_metabolis1.63834869
26MP0000350_abnormal_cell_proliferation1.54792698
27MP0002095_abnormal_skin_pigmentation1.48508912
28MP0008877_abnormal_DNA_methylation1.45229706
29MP0001697_abnormal_embryo_size1.40399898
30MP0002877_abnormal_melanocyte_morpholog1.38802641
31MP0001730_embryonic_growth_arrest1.35629698
32MP0004808_abnormal_hematopoietic_stem1.33500108
33MP0002210_abnormal_sex_determination1.29321450
34MP0008995_early_reproductive_senescence1.28795527
35MP0001545_abnormal_hematopoietic_system1.28750424
36MP0005397_hematopoietic_system_phenotyp1.28750424
37MP0003890_abnormal_embryonic-extraembry1.27350358
38MP0003718_maternal_effect1.23534334
39MP0000313_abnormal_cell_death1.23460329
40MP0005408_hypopigmentation1.18808381
41MP0005174_abnormal_tail_pigmentation1.17371675
42MP0001929_abnormal_gametogenesis1.17343311
43MP0002970_abnormal_white_adipose1.17062833
44MP0001879_abnormal_lymphatic_vessel1.15101578
45MP0003121_genomic_imprinting1.11748457
46MP0005647_abnormal_sex_gland1.08829700
47MP0003221_abnormal_cardiomyocyte_apopto1.08778747
48MP0000631_abnormal_neuroendocrine_gland1.08428048
49MP0000371_diluted_coat_color1.05985408
50MP0002938_white_spotting1.02799380
51MP0003315_abnormal_perineum_morphology1.02618788
52MP0005380_embryogenesis_phenotype1.01639739
53MP0001672_abnormal_embryogenesis/_devel1.01639739
54MP0000358_abnormal_cell_content/1.00254111
55MP0001145_abnormal_male_reproductive0.99586435
56MP0002928_abnormal_bile_duct0.99238479
57MP0001873_stomach_inflammation0.99194563
58MP0003656_abnormal_erythrocyte_physiolo0.95600779
59MP0003984_embryonic_growth_retardation0.95570106
60MP0004264_abnormal_extraembryonic_tissu0.94918903
61MP0003252_abnormal_bile_duct0.93215409
62MP0003936_abnormal_reproductive_system0.92899720
63MP0000653_abnormal_sex_gland0.92232707
64MP0009703_decreased_birth_body0.92078918
65MP0001186_pigmentation_phenotype0.90873101
66MP0003943_abnormal_hepatobiliary_system0.90579273
67MP0002075_abnormal_coat/hair_pigmentati0.90436417
68MP0005389_reproductive_system_phenotype0.90274909
69MP0002088_abnormal_embryonic_growth/wei0.90083433
70MP0001529_abnormal_vocalization0.88621540
71MP0002019_abnormal_tumor_incidence0.86799684
72MP0003698_abnormal_male_reproductive0.86667759
73MP0000627_abnormal_mammary_gland0.85666657
74MP0003186_abnormal_redox_activity0.84974880
75MP0001727_abnormal_embryo_implantation0.83383384
76MP0003699_abnormal_female_reproductive0.82437803
77MP0001119_abnormal_female_reproductive0.79472974
78MP0001661_extended_life_span0.78323198
79MP0002080_prenatal_lethality0.78284569
80MP0001919_abnormal_reproductive_system0.78039821
81MP0008775_abnormal_heart_ventricle0.77999957
82MP0002971_abnormal_brown_adipose0.77891955
83MP0008770_decreased_survivor_rate0.76144787
84MP0009115_abnormal_fat_cell0.75755696
85MP0002086_abnormal_extraembryonic_tissu0.75070528
86MP0001881_abnormal_mammary_gland0.71575667
87MP0005645_abnormal_hypothalamus_physiol0.71175403
88MP0005076_abnormal_cell_differentiation0.71160268
89MP0009672_abnormal_birth_weight0.70833619
90MP0004197_abnormal_fetal_growth/weight/0.70556206
91MP0004019_abnormal_vitamin_homeostasis0.67649722
92MP0006292_abnormal_olfactory_placode0.67379018
93MP0002733_abnormal_thermal_nociception0.66711320
94MP0008873_increased_physiological_sensi0.65476650
95MP0008872_abnormal_physiological_respon0.64595506
96MP0005084_abnormal_gallbladder_morpholo0.64233663
97MP0002085_abnormal_embryonic_tissue0.63804963
98MP0005085_abnormal_gallbladder_physiolo0.63314618
99MP0004185_abnormal_adipocyte_glucose0.62177184
100MP0000467_abnormal_esophagus_morphology0.62093890

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)8.22569627
2Chromosomal breakage induced by crosslinking agents (HP:0003221)7.74405565
3Aplasia/Hypoplasia of the uvula (HP:0010293)6.24903632
4Abnormality of chromosome stability (HP:0003220)5.95625184
5Abnormality of the preputium (HP:0100587)5.84967978
6Meckel diverticulum (HP:0002245)5.24547481
7Abnormality of the ileum (HP:0001549)5.01449068
8Flat cornea (HP:0007720)4.94377621
9Progressive external ophthalmoplegia (HP:0000590)4.81938228
10Hypoplasia of the pons (HP:0012110)4.68756562
11Abnormality of the pons (HP:0007361)4.56994081
12Small intestinal stenosis (HP:0012848)4.24256221
13Duodenal stenosis (HP:0100867)4.24256221
14Clubbing of toes (HP:0100760)4.08074806
15Abnormality of the carotid arteries (HP:0005344)4.02098909
16Acute myeloid leukemia (HP:0004808)3.93210185
17Myelodysplasia (HP:0002863)3.66243093
18Nephroblastoma (Wilms tumor) (HP:0002667)3.53720590
19Acute lymphatic leukemia (HP:0006721)3.47177165
20Embryonal renal neoplasm (HP:0011794)3.36854445
21Abnormality of the duodenum (HP:0002246)3.23879252
22Progressive inability to walk (HP:0002505)3.10110926
23Birth length less than 3rd percentile (HP:0003561)3.03309775
24Sensory axonal neuropathy (HP:0003390)2.86352426
25Keratoconus (HP:0000563)2.77074921
26Increased corneal curvature (HP:0100692)2.77074921
27Sclerocornea (HP:0000647)2.74963641
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70454544
29Bone marrow hypocellularity (HP:0005528)2.67785457
30Sloping forehead (HP:0000340)2.66543741
31Prostate neoplasm (HP:0100787)2.63850872
32Arteriovenous malformation (HP:0100026)2.63300312
33Premature ovarian failure (HP:0008209)2.54214599
34Progressive muscle weakness (HP:0003323)2.54078180
35Absent thumb (HP:0009777)2.52474483
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51571406
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.51571406
38Triphalangeal thumb (HP:0001199)2.49966043
39Embryonal neoplasm (HP:0002898)2.49290790
40Increased serum pyruvate (HP:0003542)2.47584936
41Fatigue (HP:0012378)2.40099975
42Cafe-au-lait spot (HP:0000957)2.37409561
43Clumsiness (HP:0002312)2.34845492
44Impulsivity (HP:0100710)2.33041748
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.22505339
46Abnormality of glycolysis (HP:0004366)2.21284570
47Dysphonia (HP:0001618)2.19473701
48Epileptic encephalopathy (HP:0200134)2.17963526
49Duplicated collecting system (HP:0000081)2.13672534
50Increased nuchal translucency (HP:0010880)2.13112938
51Short thumb (HP:0009778)2.12108809
52Aplasia/Hypoplasia of the earlobes (HP:0009906)2.11814169
53Megalocornea (HP:0000485)2.11396178
54Choanal atresia (HP:0000453)2.10955337
55Volvulus (HP:0002580)2.09623392
56Truncus arteriosus (HP:0001660)2.07711856
57Cerebellar dysplasia (HP:0007033)2.06156812
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02743369
59Central scotoma (HP:0000603)2.01614847
60Abnormal lung lobation (HP:0002101)1.99314531
61Poikiloderma (HP:0001029)1.99147052
62Abnormality of the renal cortex (HP:0011035)1.95160388
63Pheochromocytoma (HP:0002666)1.93229559
64Inability to walk (HP:0002540)1.92256540
65Neuroendocrine neoplasm (HP:0100634)1.90554311
66Astigmatism (HP:0000483)1.88617213
67Abnormality of the renal collecting system (HP:0004742)1.85373792
68Oligohydramnios (HP:0001562)1.85305205
69Hyperthyroidism (HP:0000836)1.83486504
70Absent/shortened dynein arms (HP:0200106)1.83263892
71Dynein arm defect of respiratory motile cilia (HP:0012255)1.83263892
72Renal cortical cysts (HP:0000803)1.82904688
73Squamous cell carcinoma (HP:0002860)1.82048830
74Hypertensive crisis (HP:0100735)1.81306989
75Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76210840
76Ragged-red muscle fibers (HP:0003200)1.75088170
77Cortical visual impairment (HP:0100704)1.74790920
78Abnormal large intestine physiology (HP:0012700)1.72989415
79External ophthalmoplegia (HP:0000544)1.71379134
80Nausea (HP:0002018)1.69363113
81Homocystinuria (HP:0002156)1.68925712
82Abnormality of homocysteine metabolism (HP:0010919)1.68925712
83Ectopic kidney (HP:0000086)1.68421626
84Type II lissencephaly (HP:0007260)1.67524812
85Oligodactyly (hands) (HP:0001180)1.66296340
86Recurrent urinary tract infections (HP:0000010)1.64655790
87Abnormality of the corticospinal tract (HP:0002492)1.63337976
88Truncal obesity (HP:0001956)1.63265233
89Bowel incontinence (HP:0002607)1.61735135
90Septate vagina (HP:0001153)1.61602070
91Increased serum lactate (HP:0002151)1.58037111
92Adrenal hypoplasia (HP:0000835)1.57775741
93Hypopigmented skin patches (HP:0001053)1.57559471
94Neoplasm of the pancreas (HP:0002894)1.56901728
95Abnormality of male internal genitalia (HP:0000022)1.55948391
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.55270247
97Abnormality of alanine metabolism (HP:0010916)1.55270247
98Hyperalaninemia (HP:0003348)1.55270247
99Ankyloglossia (HP:0010296)1.54952608
100Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.54635596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.69238335
2TTK3.58954410
3DYRK33.39231232
4TSSK63.35652520
5TAOK33.35589092
6MKNK23.12495813
7CCNB13.11459756
8TNIK2.95200559
9BMPR1B2.61880289
10PBK2.36688342
11WEE12.34657985
12MST1R2.22328400
13MKNK12.17048976
14ACVR1B2.02193385
15CDC72.00646798
16PLK41.94857471
17CHEK21.89301074
18BUB11.79651202
19WNK41.76612047
20STK101.75631058
21MAP3K21.74945186
22BRSK21.73837067
23ZAK1.65062837
24EIF2AK11.61340452
25PLK11.55088011
26EEF2K1.52091369
27PNCK1.45276463
28ATR1.44332566
29NEK11.34776175
30NME11.32513025
31CDK71.27620813
32PLK31.26512128
33EIF2AK31.23699289
34RPS6KB21.21758044
35TRPM71.16564698
36ALK1.16011068
37BMPR21.12533297
38CDK41.06563720
39MAP2K61.05267253
40SRPK11.04664746
41MAP2K31.01831413
42MAPKAPK30.99333711
43CLK10.90573511
44MELK0.84766217
45FGFR10.84571902
46NEK20.83432776
47ATM0.81294499
48MAP3K80.78061544
49CHEK10.76950997
50AURKB0.75541032
51PINK10.72475287
52BMX0.71055892
53MAP3K140.70520565
54BRD40.70079327
55TGFBR10.68849308
56STK390.68673571
57AKT20.67778004
58NTRK30.66352175
59KSR20.66296551
60BRSK10.62707900
61RIPK40.62116104
62MAP3K70.61459884
63FRK0.58880273
64RPS6KA40.58687982
65RAF10.58328007
66MAP3K60.57605966
67MET0.57288330
68MAP2K40.55571891
69MAP3K40.53561781
70CDK30.49726818
71MAPKAPK50.49603766
72VRK10.48480736
73STK30.47638844
74NUAK10.47166067
75STK40.44929348
76CDK20.42136069
77CDK10.40927318
78CSNK2A20.40571963
79PIK3CG0.36349700
80TRIM280.34447588
81CSNK1E0.33806222
82TEC0.33596152
83WNK10.33405931
84CSNK2A10.33254867
85KSR10.31472699
86MAPK140.30933008
87ERBB20.29521836
88ERBB30.29451109
89LRRK20.27180004
90SGK10.27047574
91FLT30.26829430
92MAP2K10.25477416
93MAP3K30.25128051
94GSK3B0.24325225
95AURKA0.23877790
96ERN10.23333795
97MAPK130.22542597
98PRKDC0.21786801
99MAP3K130.21127999
100CASK0.20761160

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034404.95143923
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.67725903
3Fanconi anemia pathway_Homo sapiens_hsa034604.28086772
4Fatty acid biosynthesis_Homo sapiens_hsa000613.88713061
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.87701449
6* Olfactory transduction_Homo sapiens_hsa047403.59490942
7Non-homologous end-joining_Homo sapiens_hsa034503.28719472
8One carbon pool by folate_Homo sapiens_hsa006703.15252176
9DNA replication_Homo sapiens_hsa030303.14136203
10Mismatch repair_Homo sapiens_hsa034302.89635126
11Basal transcription factors_Homo sapiens_hsa030222.46331854
12Cell cycle_Homo sapiens_hsa041102.26217590
13RNA transport_Homo sapiens_hsa030132.21935438
14Spliceosome_Homo sapiens_hsa030402.10974172
15RNA degradation_Homo sapiens_hsa030181.95699588
16Nucleotide excision repair_Homo sapiens_hsa034201.91269967
17RNA polymerase_Homo sapiens_hsa030201.84406869
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55602221
19Base excision repair_Homo sapiens_hsa034101.51633448
20Proteasome_Homo sapiens_hsa030501.40480884
21mRNA surveillance pathway_Homo sapiens_hsa030151.34960127
22Fatty acid metabolism_Homo sapiens_hsa012121.31697736
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24091454
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.22179570
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.21447501
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16656287
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14537628
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13446354
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10575176
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07020467
31Pyruvate metabolism_Homo sapiens_hsa006201.05895456
32Ribosome_Homo sapiens_hsa030101.05151235
33Pyrimidine metabolism_Homo sapiens_hsa002401.03725482
34Purine metabolism_Homo sapiens_hsa002300.90692767
35Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89057403
36NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84506436
37p53 signaling pathway_Homo sapiens_hsa041150.78941750
38Glutathione metabolism_Homo sapiens_hsa004800.73199847
39Oocyte meiosis_Homo sapiens_hsa041140.71454563
40Propanoate metabolism_Homo sapiens_hsa006400.70725653
41Epstein-Barr virus infection_Homo sapiens_hsa051690.69928085
42Hedgehog signaling pathway_Homo sapiens_hsa043400.68770129
43Huntingtons disease_Homo sapiens_hsa050160.67154023
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64272069
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61836248
46Wnt signaling pathway_Homo sapiens_hsa043100.60593962
47Selenocompound metabolism_Homo sapiens_hsa004500.57223724
48Parkinsons disease_Homo sapiens_hsa050120.56466375
49Thyroid cancer_Homo sapiens_hsa052160.54672406
50Steroid biosynthesis_Homo sapiens_hsa001000.54335997
51Basal cell carcinoma_Homo sapiens_hsa052170.51486577
52Ether lipid metabolism_Homo sapiens_hsa005650.49768979
53Butanoate metabolism_Homo sapiens_hsa006500.49092770
54Measles_Homo sapiens_hsa051620.47439482
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45883155
56Pentose phosphate pathway_Homo sapiens_hsa000300.44810284
57Cocaine addiction_Homo sapiens_hsa050300.42733498
58Viral carcinogenesis_Homo sapiens_hsa052030.42403794
59Oxidative phosphorylation_Homo sapiens_hsa001900.41396659
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39443369
61Arginine and proline metabolism_Homo sapiens_hsa003300.38674403
62Inositol phosphate metabolism_Homo sapiens_hsa005620.37027583
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35938046
64ErbB signaling pathway_Homo sapiens_hsa040120.35457037
65Metabolic pathways_Homo sapiens_hsa011000.33849324
66TGF-beta signaling pathway_Homo sapiens_hsa043500.33587876
67Vitamin B6 metabolism_Homo sapiens_hsa007500.32542588
68Pancreatic cancer_Homo sapiens_hsa052120.31992747
69Fatty acid degradation_Homo sapiens_hsa000710.30904649
70Herpes simplex infection_Homo sapiens_hsa051680.30832389
71Peroxisome_Homo sapiens_hsa041460.30663922
72Linoleic acid metabolism_Homo sapiens_hsa005910.30621998
73Nicotine addiction_Homo sapiens_hsa050330.30293186
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29881427
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29081251
76Type II diabetes mellitus_Homo sapiens_hsa049300.26474443
77Adherens junction_Homo sapiens_hsa045200.26009453
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25589091
79Melanogenesis_Homo sapiens_hsa049160.24282292
80HTLV-I infection_Homo sapiens_hsa051660.23928388
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.21834036
82Sphingolipid metabolism_Homo sapiens_hsa006000.21658961
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21252908
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19734433
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19513548
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19223897
87Folate biosynthesis_Homo sapiens_hsa007900.18742431
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.16199305
89Alcoholism_Homo sapiens_hsa050340.15536220
90Biosynthesis of amino acids_Homo sapiens_hsa012300.14407280
91Carbon metabolism_Homo sapiens_hsa012000.13226560
92Nitrogen metabolism_Homo sapiens_hsa009100.12199311
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11952376
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.10820587
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09206295
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.08038783
97Alzheimers disease_Homo sapiens_hsa050100.07684479
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.07422320
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06897926
100Prostate cancer_Homo sapiens_hsa052150.06679919

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »