OR51I2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)8.36259876
2DNA replication checkpoint (GO:0000076)7.08473244
3nuclear pore complex assembly (GO:0051292)6.64012138
4DNA topological change (GO:0006265)6.19484069
5* sensory perception of smell (GO:0007608)6.15095597
6nuclear pore organization (GO:0006999)5.74818285
7* detection of chemical stimulus involved in sensory perception (GO:0050907)5.26587671
8regulation of translational fidelity (GO:0006450)5.15225675
9regulation of centriole replication (GO:0046599)5.12023435
10mitotic nuclear envelope disassembly (GO:0007077)5.11221048
11cellular ketone body metabolic process (GO:0046950)5.09500582
12pore complex assembly (GO:0046931)5.01799644
13mitotic G2/M transition checkpoint (GO:0044818)5.00734680
14DNA replication initiation (GO:0006270)4.80303062
15DNA strand elongation involved in DNA replication (GO:0006271)4.79745143
16membrane disassembly (GO:0030397)4.76258021
17nuclear envelope disassembly (GO:0051081)4.76258021
18DNA strand elongation (GO:0022616)4.54483945
19ketone body metabolic process (GO:1902224)4.50612461
20positive regulation of histone H3-K4 methylation (GO:0051571)4.44956065
21meiotic chromosome segregation (GO:0045132)4.43136326
22tRNA aminoacylation for protein translation (GO:0006418)4.38527337
23centriole replication (GO:0007099)4.32638249
24regulation of double-strand break repair via homologous recombination (GO:0010569)4.26837763
25inner mitochondrial membrane organization (GO:0007007)4.23624247
26rRNA methylation (GO:0031167)4.20869167
27tRNA aminoacylation (GO:0043039)4.19679593
28amino acid activation (GO:0043038)4.19679593
29mitotic G2 DNA damage checkpoint (GO:0007095)4.16800542
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.09319790
31regulation of histone H3-K4 methylation (GO:0051569)4.07803523
32synapsis (GO:0007129)4.02937405
33mitochondrial RNA metabolic process (GO:0000959)3.81867867
34double-strand break repair via homologous recombination (GO:0000724)3.81495038
35nucleobase biosynthetic process (GO:0046112)3.80524640
36IMP biosynthetic process (GO:0006188)3.77623472
37recombinational repair (GO:0000725)3.73141458
38* detection of chemical stimulus (GO:0009593)3.71648499
39regulation of memory T cell differentiation (GO:0043380)3.61753005
40protein localization to kinetochore (GO:0034501)3.60360997
41chromosome segregation (GO:0007059)3.60194678
42organelle disassembly (GO:1903008)3.56840412
43proteasome assembly (GO:0043248)3.55636279
44mitotic sister chromatid segregation (GO:0000070)3.55415092
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.52755774
46replication fork processing (GO:0031297)3.51920957
47erythrocyte maturation (GO:0043249)3.51336237
48regulation of centrosome cycle (GO:0046605)3.50051988
49negative regulation of DNA-dependent DNA replication (GO:2000104)3.49530728
50DNA geometric change (GO:0032392)3.49256624
51IMP metabolic process (GO:0046040)3.46391148
52protein localization to chromosome, centromeric region (GO:0071459)3.46297450
53DNA duplex unwinding (GO:0032508)3.45084180
54chromosome organization involved in meiosis (GO:0070192)3.44956200
55telomere maintenance via semi-conservative replication (GO:0032201)3.44683218
56regulation of centrosome duplication (GO:0010824)3.43406836
57mitotic recombination (GO:0006312)3.42676077
58nuclear envelope organization (GO:0006998)3.40220517
59ribonucleoprotein complex disassembly (GO:0032988)3.39463641
60sister chromatid segregation (GO:0000819)3.39361494
61protoporphyrinogen IX metabolic process (GO:0046501)3.39357111
62rRNA modification (GO:0000154)3.38306891
63definitive hemopoiesis (GO:0060216)3.37165718
64DNA conformation change (GO:0071103)3.35682776
65regulation of RNA export from nucleus (GO:0046831)3.34666730
66telomere maintenance via recombination (GO:0000722)3.34444310
67centriole assembly (GO:0098534)3.33711362
68DNA strand renaturation (GO:0000733)3.30715887
69* sensory perception of chemical stimulus (GO:0007606)3.30326240
70sleep (GO:0030431)3.29143113
71purine nucleobase biosynthetic process (GO:0009113)3.28746281
72embryonic placenta development (GO:0001892)3.23097761
73neurotransmitter catabolic process (GO:0042135)3.20230739
74protoporphyrinogen IX biosynthetic process (GO:0006782)3.19143895
75positive regulation of cytokinesis (GO:0032467)3.17722255
76kinetochore organization (GO:0051383)3.15247199
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12091352
78mitotic chromosome condensation (GO:0007076)3.10406743
79regulation of translational elongation (GO:0006448)3.10338252
80resolution of meiotic recombination intermediates (GO:0000712)3.06551025
81microtubule nucleation (GO:0007020)3.06133220
82G2 DNA damage checkpoint (GO:0031572)3.05991740
83protein localization to chromosome (GO:0034502)3.05610374
84ribosome biogenesis (GO:0042254)3.04939857
85positive regulation of histone methylation (GO:0031062)3.01579253
86regulation of mitotic spindle organization (GO:0060236)3.00124955
87regulation of histone H3-K9 methylation (GO:0051570)2.98273836
88reciprocal DNA recombination (GO:0035825)2.97210457
89reciprocal meiotic recombination (GO:0007131)2.97210457
90protein K6-linked ubiquitination (GO:0085020)2.96894217
91regulation of double-strand break repair (GO:2000779)2.95894753
92DNA replication (GO:0006260)2.94499516
93positive regulation of cell cycle G2/M phase transition (GO:1902751)2.94388533
94positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.94388533
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93809346
96centrosome organization (GO:0051297)2.93679953
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.93467827
98folic acid-containing compound biosynthetic process (GO:0009396)2.93258993
99DNA unwinding involved in DNA replication (GO:0006268)2.93043952
100pseudouridine synthesis (GO:0001522)2.92170933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.85131364
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50752435
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.24886226
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61008038
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.55883865
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29959872
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95196463
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.93886845
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84756965
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.64023214
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47160855
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34195003
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25767871
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.23555322
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.21556035
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.21138721
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.19613964
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.10831747
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10741996
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00453110
21E2F7_22180533_ChIP-Seq_HELA_Human10.2712203
22VDR_23849224_ChIP-Seq_CD4+_Human1.98180325
23DCP1A_22483619_ChIP-Seq_HELA_Human1.97982170
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96899147
25ELK1_19687146_ChIP-ChIP_HELA_Human1.92696350
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92649393
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89859100
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85208002
29GATA1_22025678_ChIP-Seq_K562_Human1.82054360
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81586667
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69023417
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.67610241
33AR_21909140_ChIP-Seq_LNCAP_Human1.62903147
34NCOR1_26117541_ChIP-Seq_K562_Human1.61709395
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59186768
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58849684
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57736108
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.57441358
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52715573
40GABP_19822575_ChIP-Seq_HepG2_Human1.51973051
41VDR_22108803_ChIP-Seq_LS180_Human1.51079851
42EWS_26573619_Chip-Seq_HEK293_Human1.49864761
43KDM5A_27292631_Chip-Seq_BREAST_Human1.48074437
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47480388
45XRN2_22483619_ChIP-Seq_HELA_Human1.44866376
46FOXP3_21729870_ChIP-Seq_TREG_Human1.43365216
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42214840
48GATA1_19941826_ChIP-Seq_K562_Human1.34820805
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33797112
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33577615
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33450562
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32929489
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30548679
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26098291
55TTF2_22483619_ChIP-Seq_HELA_Human1.25550898
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24654204
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24195808
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22676559
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19060311
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18937701
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17593671
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10939346
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09250724
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07773824
65ZNF274_21170338_ChIP-Seq_K562_Hela1.06437620
66TFEB_21752829_ChIP-Seq_HELA_Human1.05290113
67GATA2_19941826_ChIP-Seq_K562_Human1.00488736
68ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97460622
69IGF1R_20145208_ChIP-Seq_DFB_Human0.96213008
70SPI1_23127762_ChIP-Seq_K562_Human0.94831741
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93958078
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93321437
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89696232
74ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88290881
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87147327
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86453339
77MYC_18940864_ChIP-ChIP_HL60_Human0.85962354
78POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84472768
79PHF8_20622853_ChIP-Seq_HELA_Human0.83431020
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79876616
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78358197
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77882057
83CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76999980
84ZNF263_19887448_ChIP-Seq_K562_Human0.76395467
85ER_23166858_ChIP-Seq_MCF-7_Human0.76370150
86SALL4_22934838_ChIP-ChIP_CD34+_Human0.75082626
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74194636
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74150254
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.74098503
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73971184
91HNFA_21074721_ChIP-Seq_CACO-2_Human0.72620049
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72242631
93SCL_19346495_ChIP-Seq_HPC-7_Human0.72220633
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.71290219
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70629191
96NFYB_21822215_ChIP-Seq_K562_Human0.70552649
97* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.70206548
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.69797417
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69368203
100ETV1_20927104_ChIP-Seq_GIST48_Human0.68843714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.68471329
2MP0003806_abnormal_nucleotide_metabolis5.38734327
3MP0008057_abnormal_DNA_replication4.61265936
4MP0010094_abnormal_chromosome_stability4.24910582
5MP0008058_abnormal_DNA_repair4.24507907
6MP0008995_early_reproductive_senescence4.09730391
7MP0004885_abnormal_endolymph4.03036902
8MP0003786_premature_aging3.91972657
9MP0003111_abnormal_nucleus_morphology3.36664348
10MP0009697_abnormal_copulation3.22097644
11MP0004147_increased_porphyrin_level3.15013396
12MP0004957_abnormal_blastocyst_morpholog2.91015352
13MP0008007_abnormal_cellular_replicative2.82202361
14MP0003077_abnormal_cell_cycle2.41446963
15MP0002009_preneoplasia2.30496996
16MP0005083_abnormal_biliary_tract2.23859581
17MP0001873_stomach_inflammation2.17441446
18MP0003656_abnormal_erythrocyte_physiolo2.07509070
19MP0003693_abnormal_embryo_hatching1.82679938
20MP0003646_muscle_fatigue1.70251064
21MP0006036_abnormal_mitochondrial_physio1.61915984
22MP0001929_abnormal_gametogenesis1.56409317
23MP0005397_hematopoietic_system_phenotyp1.54595240
24MP0001545_abnormal_hematopoietic_system1.54595240
25MP0001697_abnormal_embryo_size1.52052165
26MP0006035_abnormal_mitochondrial_morpho1.52011340
27MP0008932_abnormal_embryonic_tissue1.50038461
28MP0001661_extended_life_span1.45651630
29MP0005174_abnormal_tail_pigmentation1.43124239
30MP0003718_maternal_effect1.42256010
31MP0000313_abnormal_cell_death1.40236640
32MP0002160_abnormal_reproductive_system1.36681968
33MP0002095_abnormal_skin_pigmentation1.34852680
34MP0000015_abnormal_ear_pigmentation1.33913518
35MP0002210_abnormal_sex_determination1.31812124
36MP0010307_abnormal_tumor_latency1.28082892
37MP0005266_abnormal_metabolism1.26020801
38MP0003984_embryonic_growth_retardation1.24938502
39MP0002088_abnormal_embryonic_growth/wei1.20726324
40MP0005408_hypopigmentation1.20536224
41MP0005380_embryogenesis_phenotype1.18265527
42MP0001672_abnormal_embryogenesis/_devel1.18265527
43MP0004019_abnormal_vitamin_homeostasis1.15871136
44MP0003698_abnormal_male_reproductive1.10926202
45MP0000678_abnormal_parathyroid_gland1.06790868
46MP0000350_abnormal_cell_proliferation1.06648531
47MP0002086_abnormal_extraembryonic_tissu1.06149353
48MP0002132_abnormal_respiratory_system1.05432549
49MP0001881_abnormal_mammary_gland1.04244455
50MP0002396_abnormal_hematopoietic_system1.02449765
51MP0001730_embryonic_growth_arrest1.00361110
52MP0001529_abnormal_vocalization0.99049509
53MP0002080_prenatal_lethality0.98463498
54MP0005410_abnormal_fertilization0.95310464
55MP0001919_abnormal_reproductive_system0.93498978
56MP0001145_abnormal_male_reproductive0.92812525
57MP0009765_abnormal_xenobiotic_induced0.90591281
58MP0008775_abnormal_heart_ventricle0.87989969
59MP0002019_abnormal_tumor_incidence0.86429318
60MP0005171_absent_coat_pigmentation0.83202436
61MP0000358_abnormal_cell_content/0.82528292
62MP0008872_abnormal_physiological_respon0.81709405
63MP0003699_abnormal_female_reproductive0.81357962
64MP0003385_abnormal_body_wall0.81183556
65MP0005376_homeostasis/metabolism_phenot0.79728369
66MP0000653_abnormal_sex_gland0.78435261
67MP0005389_reproductive_system_phenotype0.78405580
68MP0002970_abnormal_white_adipose0.76522779
69MP0008770_decreased_survivor_rate0.75847966
70MP0008875_abnormal_xenobiotic_pharmacok0.74316199
71MP0004185_abnormal_adipocyte_glucose0.71478947
72MP0002161_abnormal_fertility/fecundity0.70850692
73MP0004145_abnormal_muscle_electrophysio0.70655557
74MP0004197_abnormal_fetal_growth/weight/0.69792770
75MP0001764_abnormal_homeostasis0.69780916
76MP0002084_abnormal_developmental_patter0.69472806
77MP0002085_abnormal_embryonic_tissue0.68336575
78MP0005636_abnormal_mineral_homeostasis0.68196181
79MP0000372_irregular_coat_pigmentation0.66368647
80MP0005075_abnormal_melanosome_morpholog0.66136311
81MP0006292_abnormal_olfactory_placode0.64767682
82MP0006276_abnormal_autonomic_nervous0.63763718
83MP0009046_muscle_twitch0.63150717
84MP0002269_muscular_atrophy0.61197828
85MP0003221_abnormal_cardiomyocyte_apopto0.60218076
86MP0001666_abnormal_nutrient_absorption0.56807295
87MP0005647_abnormal_sex_gland0.55637665
88MP0002398_abnormal_bone_marrow0.55585247
89MP0009840_abnormal_foam_cell0.55486499
90MP0004808_abnormal_hematopoietic_stem0.54383336
91MP0003186_abnormal_redox_activity0.54109474
92MP0000703_abnormal_thymus_morphology0.53358307
93MP0003705_abnormal_hypodermis_morpholog0.52593972
94MP0000371_diluted_coat_color0.52189051
95MP0001186_pigmentation_phenotype0.51711780
96MP0001119_abnormal_female_reproductive0.51676412
97MP0006072_abnormal_retinal_apoptosis0.51512114
98MP0009278_abnormal_bone_marrow0.51173125
99MP0003172_abnormal_lysosome_physiology0.48411530
100MP0002722_abnormal_immune_system0.47161958

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.00545110
2Chromsome breakage (HP:0040012)5.98062501
3Abnormality of chromosome stability (HP:0003220)4.76254272
4Duplicated collecting system (HP:0000081)4.57386926
5Aplasia/Hypoplasia of the uvula (HP:0010293)4.37164926
6Abnormality of the renal collecting system (HP:0004742)4.18653121
7Abnormality of the preputium (HP:0100587)4.10514868
8Abnormality of DNA repair (HP:0003254)4.05011430
9Meckel diverticulum (HP:0002245)3.82932392
10Birth length less than 3rd percentile (HP:0003561)3.78425193
11Truncus arteriosus (HP:0001660)3.73029454
12Abnormality of the ileum (HP:0001549)3.66236106
13Small intestinal stenosis (HP:0012848)3.62891904
14Duodenal stenosis (HP:0100867)3.62891904
15Hyperthyroidism (HP:0000836)3.41806028
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.41617525
17Ragged-red muscle fibers (HP:0003200)3.36553037
18Hypoplasia of the pons (HP:0012110)3.35349415
19Aplasia cutis congenita (HP:0001057)3.35183946
20Limb hypertonia (HP:0002509)3.33472333
21Abnormality of the aortic arch (HP:0012303)3.31873238
22Abnormality of the pons (HP:0007361)3.31154152
23Reticulocytosis (HP:0001923)3.19977428
24Clubbing of toes (HP:0100760)3.19110690
25Fatigue (HP:0012378)3.10488644
26Abnormality of reticulocytes (HP:0004312)3.07842879
27Acute encephalopathy (HP:0006846)3.06995659
28Abnormality of the carotid arteries (HP:0005344)3.05597293
29Acute necrotizing encephalopathy (HP:0006965)3.04685086
30Midline defect of the nose (HP:0004122)3.04341688
31Abnormality of cochlea (HP:0000375)3.03756728
32Poikilocytosis (HP:0004447)3.03579699
33Progressive external ophthalmoplegia (HP:0000590)3.02073464
34Absent thumb (HP:0009777)2.97342074
35Acanthocytosis (HP:0001927)2.94807597
36Myelodysplasia (HP:0002863)2.90647182
37Hypertensive crisis (HP:0100735)2.87280467
38Acute lymphatic leukemia (HP:0006721)2.85876303
39Abnormal mitochondria in muscle tissue (HP:0008316)2.84508436
40Acute myeloid leukemia (HP:0004808)2.83397303
41Reticulocytopenia (HP:0001896)2.82225496
42Hypoplastic pelvis (HP:0008839)2.78407771
43Abnormality of the duodenum (HP:0002246)2.75492297
44Severe visual impairment (HP:0001141)2.72274181
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.63933664
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61230298
47Arteriovenous malformation (HP:0100026)2.57566902
48Progressive macrocephaly (HP:0004481)2.56908422
49Septate vagina (HP:0001153)2.48943495
50Abnormality of pyrimidine metabolism (HP:0004353)2.48239569
51Median cleft lip (HP:0000161)2.44739215
52Progressive muscle weakness (HP:0003323)2.42000350
53Cafe-au-lait spot (HP:0000957)2.37686821
54Bowel incontinence (HP:0002607)2.32463906
55Abnormal large intestine physiology (HP:0012700)2.30795914
56Pallor (HP:0000980)2.30668317
57Abnormal lung lobation (HP:0002101)2.28730793
58Albinism (HP:0001022)2.26096766
59Morphological abnormality of the inner ear (HP:0011390)2.22238783
60Hypoparathyroidism (HP:0000829)2.21733399
61Sloping forehead (HP:0000340)2.21253372
62Vaginal fistula (HP:0004320)2.19392754
63Breast hypoplasia (HP:0003187)2.17365480
64Polycythemia (HP:0001901)2.13429386
65Hypergonadotropic hypogonadism (HP:0000815)2.12312544
663-Methylglutaconic aciduria (HP:0003535)2.12193928
67Seborrheic dermatitis (HP:0001051)2.11859445
68Tinnitus (HP:0000360)2.10817608
69Short middle phalanx of the 5th finger (HP:0004220)2.08813327
70Abnormality of lateral ventricle (HP:0030047)2.06269916
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.06073759
72Poikiloderma (HP:0001029)2.02823370
73Overlapping toe (HP:0001845)2.02165924
74Abnormality of the tricuspid valve (HP:0001702)2.01565911
75Ureteral duplication (HP:0000073)2.01064010
76Short tibia (HP:0005736)1.99732005
77Bone marrow hypocellularity (HP:0005528)1.99435460
78Sandal gap (HP:0001852)1.98312477
79Upslanted palpebral fissure (HP:0000582)1.98312416
80Premature ovarian failure (HP:0008209)1.96755129
81Abnormality of homocysteine metabolism (HP:0010919)1.95321422
82Homocystinuria (HP:0002156)1.95321422
83Spastic tetraparesis (HP:0001285)1.95242647
84Short thumb (HP:0009778)1.92446899
85Triphalangeal thumb (HP:0001199)1.91251258
86Atrioventricular canal defect (HP:0006695)1.91165985
87Heterotopia (HP:0002282)1.89663408
88Metaphyseal dysplasia (HP:0100255)1.89344192
89Oligohydramnios (HP:0001562)1.88272865
90Type II lissencephaly (HP:0007260)1.88115382
91Rectal fistula (HP:0100590)1.87625102
92Rectovaginal fistula (HP:0000143)1.87625102
93Horseshoe kidney (HP:0000085)1.83915176
94Squamous cell carcinoma (HP:0002860)1.83705512
95Complete atrioventricular canal defect (HP:0001674)1.82556670
96Sensory axonal neuropathy (HP:0003390)1.82071834
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79191274
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78873290
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78873290
100Type I transferrin isoform profile (HP:0003642)1.78653048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.81452765
2MST43.87278507
3CDC73.82520921
4TTK3.51885003
5EIF2AK13.23609290
6PLK43.18604734
7BRSK23.07517522
8WEE12.44973161
9CCNB12.34500451
10CHEK21.97503089
11ZAK1.90301183
12NEK11.90142431
13TEC1.64648638
14NTRK31.64195288
15NUAK11.60179811
16MAPK111.56706363
17KSR21.56012668
18BRD41.46101460
19RAF11.42768296
20WNK41.41550903
21RIPK41.38289151
22SRPK11.38261165
23MST1R1.36702659
24EEF2K1.35668149
25ALK1.31093091
26ATR1.28665101
27PLK11.26220050
28PBK1.25519782
29TNIK1.25507012
30MAP3K21.25073930
31BRSK11.24095323
32EIF2AK31.23535450
33BUB11.22752637
34NEK21.20951755
35BMPR21.20269796
36TSSK61.17967574
37CLK11.13609086
38MAPK131.13181150
39CHEK11.01406515
40ATM0.96676526
41PLK30.92600250
42PDK20.92377698
43PRKAA10.89433063
44IRAK30.85613773
45MAP3K80.84340864
46FRK0.83525563
47KSR10.81624936
48MAPK120.80453318
49TRPM70.80238794
50PINK10.79939108
51SCYL20.79260521
52NME10.78441050
53MKNK10.75111581
54MKNK20.73159552
55STK160.71480200
56WNK10.71002714
57AURKB0.65310562
58CDK10.65307984
59ERBB40.63095764
60AKT30.62246076
61DYRK30.61281676
62RPS6KB20.60644385
63MAP2K10.60463699
64CSNK1E0.56731833
65ERBB30.56202455
66DAPK10.55189193
67CDK40.54816022
68MAP3K40.53564847
69CDK20.53112268
70CSNK2A20.51235686
71MAP4K20.49125679
72JAK20.48281253
73NEK60.46536751
74STK100.46424977
75STK390.46375381
76CDK80.44187207
77MAPK140.39968722
78MAPK100.36860292
79STK30.35988177
80RPS6KA40.35896378
81FGFR10.34701903
82PAK60.34278837
83GSK3B0.33165537
84EIF2AK20.32809411
85AURKA0.31580762
86BRAF0.30461182
87MAPKAPK50.29033792
88RPS6KA50.28827065
89MAPKAPK30.28704024
90MET0.28416859
91CSNK2A10.27808797
92YES10.27658799
93PRKDC0.27074921
94STK40.26837184
95MAP2K30.26704990
96MTOR0.23882454
97CAMK1D0.23142839
98BTK0.22765154
99RPS6KB10.21966728
100AKT20.20629510

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034405.55399545
2* Olfactory transduction_Homo sapiens_hsa047405.00663451
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.90449673
4Fanconi anemia pathway_Homo sapiens_hsa034604.18318750
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.93626107
6DNA replication_Homo sapiens_hsa030303.30167761
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12055601
8One carbon pool by folate_Homo sapiens_hsa006702.89896408
9Non-homologous end-joining_Homo sapiens_hsa034502.65363144
10RNA transport_Homo sapiens_hsa030132.53894762
11Butanoate metabolism_Homo sapiens_hsa006502.46089567
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.33497902
13Mismatch repair_Homo sapiens_hsa034302.13129872
14Cell cycle_Homo sapiens_hsa041102.09570771
15Basal transcription factors_Homo sapiens_hsa030222.06390341
16Nucleotide excision repair_Homo sapiens_hsa034201.86420268
17Spliceosome_Homo sapiens_hsa030401.73945822
18Base excision repair_Homo sapiens_hsa034101.44058603
19RNA polymerase_Homo sapiens_hsa030201.39525247
20mRNA surveillance pathway_Homo sapiens_hsa030151.34774873
21Ribosome_Homo sapiens_hsa030101.31868623
22Steroid biosynthesis_Homo sapiens_hsa001001.31724246
23RNA degradation_Homo sapiens_hsa030181.28577198
24Pyrimidine metabolism_Homo sapiens_hsa002401.23912852
25Parkinsons disease_Homo sapiens_hsa050121.19685455
26Selenocompound metabolism_Homo sapiens_hsa004501.15759690
27Fructose and mannose metabolism_Homo sapiens_hsa000511.12731480
28Oxidative phosphorylation_Homo sapiens_hsa001901.07383757
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07279091
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.00140306
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97740765
32Purine metabolism_Homo sapiens_hsa002300.93710645
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85647260
34Cysteine and methionine metabolism_Homo sapiens_hsa002700.80625260
35NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75535837
36Oocyte meiosis_Homo sapiens_hsa041140.72711194
37Alzheimers disease_Homo sapiens_hsa050100.71614869
38Huntingtons disease_Homo sapiens_hsa050160.71422141
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70467454
40Vitamin B6 metabolism_Homo sapiens_hsa007500.68620748
41Taste transduction_Homo sapiens_hsa047420.68326683
42Acute myeloid leukemia_Homo sapiens_hsa052210.68241159
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67732411
44p53 signaling pathway_Homo sapiens_hsa041150.66896614
45Chronic myeloid leukemia_Homo sapiens_hsa052200.58979590
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56920623
47Glutathione metabolism_Homo sapiens_hsa004800.53433977
48Lysine degradation_Homo sapiens_hsa003100.53329937
49Sulfur relay system_Homo sapiens_hsa041220.51883952
50Viral carcinogenesis_Homo sapiens_hsa052030.50754298
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46532482
52Alcoholism_Homo sapiens_hsa050340.45967181
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45965963
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45529407
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44524456
56Linoleic acid metabolism_Homo sapiens_hsa005910.39349390
57N-Glycan biosynthesis_Homo sapiens_hsa005100.38145585
58ErbB signaling pathway_Homo sapiens_hsa040120.37972128
59Metabolic pathways_Homo sapiens_hsa011000.35509362
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35499817
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34561167
62Regulation of autophagy_Homo sapiens_hsa041400.32973910
63Ether lipid metabolism_Homo sapiens_hsa005650.32456192
64Proteasome_Homo sapiens_hsa030500.31192905
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.30972457
66Pyruvate metabolism_Homo sapiens_hsa006200.30646488
67Pancreatic cancer_Homo sapiens_hsa052120.30237362
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30114631
69Systemic lupus erythematosus_Homo sapiens_hsa053220.29770659
70Renal cell carcinoma_Homo sapiens_hsa052110.26689387
71Prolactin signaling pathway_Homo sapiens_hsa049170.26538986
72Retinol metabolism_Homo sapiens_hsa008300.24022038
73Non-small cell lung cancer_Homo sapiens_hsa052230.23543103
74Measles_Homo sapiens_hsa051620.23205573
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.22315662
76Type II diabetes mellitus_Homo sapiens_hsa049300.21411716
77Thyroid cancer_Homo sapiens_hsa052160.20316674
78Fatty acid biosynthesis_Homo sapiens_hsa000610.19318289
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.19288570
80Dorso-ventral axis formation_Homo sapiens_hsa043200.18643385
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17430936
82MicroRNAs in cancer_Homo sapiens_hsa052060.17251238
83HIF-1 signaling pathway_Homo sapiens_hsa040660.17226443
84Glioma_Homo sapiens_hsa052140.17186074
85Sphingolipid metabolism_Homo sapiens_hsa006000.14937565
86Propanoate metabolism_Homo sapiens_hsa006400.14377407
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13973284
88Other glycan degradation_Homo sapiens_hsa005110.13727419
89Nitrogen metabolism_Homo sapiens_hsa009100.12977461
90mTOR signaling pathway_Homo sapiens_hsa041500.12088617
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11898784
92Arginine biosynthesis_Homo sapiens_hsa002200.11223447
93Fat digestion and absorption_Homo sapiens_hsa049750.09303996
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08673550
95HTLV-I infection_Homo sapiens_hsa051660.08617320
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08466871
97Prostate cancer_Homo sapiens_hsa052150.07479120
98B cell receptor signaling pathway_Homo sapiens_hsa046620.06867504
99Apoptosis_Homo sapiens_hsa042100.06562889
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05832587

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