OR51J1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lipopolysaccharide biosynthetic process (GO:0009103)7.43251974
2regulation of chemokine biosynthetic process (GO:0045073)7.28494590
3cellular extravasation (GO:0045123)6.82631061
4cellular response to exogenous dsRNA (GO:0071360)6.66020435
5positive regulation of chemokine biosynthetic process (GO:0045080)6.34340818
6lipopolysaccharide metabolic process (GO:0008653)6.33536858
7rRNA methylation (GO:0031167)5.60400084
8* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.58720327
9ether lipid metabolic process (GO:0046485)5.36277387
10microglial cell activation (GO:0001774)5.31922270
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.23100353
12motile cilium assembly (GO:0044458)5.12408700
13reciprocal DNA recombination (GO:0035825)5.09252543
14reciprocal meiotic recombination (GO:0007131)5.09252543
15rRNA modification (GO:0000154)5.03665026
16synaptonemal complex assembly (GO:0007130)4.82722211
17centriole assembly (GO:0098534)4.72794425
18* sensory perception of smell (GO:0007608)4.71005903
19pyrimidine nucleotide catabolic process (GO:0006244)4.61877943
20killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.55367198
21disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.55367198
22replication fork processing (GO:0031297)4.53295452
23pyrimidine dimer repair (GO:0006290)4.34364502
24pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.30022862
25protoporphyrinogen IX biosynthetic process (GO:0006782)4.23379610
26synaptonemal complex organization (GO:0070193)4.20428077
27resolution of meiotic recombination intermediates (GO:0000712)4.11650885
28glycerol ether metabolic process (GO:0006662)3.94777257
29negative regulation of chemokine production (GO:0032682)3.87091882
30chromosome organization involved in meiosis (GO:0070192)3.86141994
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.83633108
32cellular response to interferon-beta (GO:0035458)3.82932235
33* detection of chemical stimulus involved in sensory perception (GO:0050907)3.78887580
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.78080817
35regulation of MHC class II biosynthetic process (GO:0045346)3.73747216
36protoporphyrinogen IX metabolic process (GO:0046501)3.72669845
37neutrophil mediated immunity (GO:0002446)3.65520388
38ether metabolic process (GO:0018904)3.64433043
39positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.58028140
40telomere maintenance via telomerase (GO:0007004)3.47593678
41regulation of centriole replication (GO:0046599)3.43526276
42DNA topological change (GO:0006265)3.37751795
43cellular response to dsRNA (GO:0071359)3.34391615
44negative regulation of protein acetylation (GO:1901984)3.30362350
45alanine transport (GO:0032328)3.29281909
46proteasome assembly (GO:0043248)3.28411525
47mitotic recombination (GO:0006312)3.25861215
48centriole replication (GO:0007099)3.21846276
49mitochondrial DNA replication (GO:0006264)3.16352347
50aggressive behavior (GO:0002118)3.12795778
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05033511
52telomere maintenance via semi-conservative replication (GO:0032201)3.02320982
53telomere maintenance (GO:0000723)3.01918880
54negative regulation of interleukin-8 production (GO:0032717)3.01536701
55pseudouridine synthesis (GO:0001522)3.01320622
56response to interferon-beta (GO:0035456)2.99778880
57telomere organization (GO:0032200)2.99461521
58somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98012370
59somatic hypermutation of immunoglobulin genes (GO:0016446)2.98012370
60histone H3-K9 methylation (GO:0051567)2.97166338
61intra-S DNA damage checkpoint (GO:0031573)2.94626165
62DNA synthesis involved in DNA repair (GO:0000731)2.93802140
63purine nucleobase biosynthetic process (GO:0009113)2.91905225
64double-strand break repair via homologous recombination (GO:0000724)2.89616895
65somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88478611
66somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88478611
67isotype switching (GO:0045190)2.88478611
68deoxyribonucleotide catabolic process (GO:0009264)2.88229467
69telomere maintenance via telomere lengthening (GO:0010833)2.86354381
70telomere maintenance via recombination (GO:0000722)2.84968370
71termination of RNA polymerase I transcription (GO:0006363)2.84523144
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.82988610
73energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82936360
74ATP synthesis coupled proton transport (GO:0015986)2.82936360
75recombinational repair (GO:0000725)2.81382322
76non-recombinational repair (GO:0000726)2.80530118
77double-strand break repair via nonhomologous end joining (GO:0006303)2.80530118
78myeloid leukocyte mediated immunity (GO:0002444)2.79825996
79regulation of prostaglandin secretion (GO:0032306)2.78701579
80L-serine transport (GO:0015825)2.78550207
81oxidative phosphorylation (GO:0006119)2.78532174
82deoxyribose phosphate catabolic process (GO:0046386)2.78414400
83RNA-dependent DNA replication (GO:0006278)2.76865276
84regulation of memory T cell differentiation (GO:0043380)2.75609740
85positive regulation of mitochondrial fission (GO:0090141)2.72631909
86folic acid metabolic process (GO:0046655)2.70439747
87DNA replication checkpoint (GO:0000076)2.69363970
88protein K6-linked ubiquitination (GO:0085020)2.66477433
89DNA strand elongation (GO:0022616)2.64559817
90positive regulation of prostaglandin secretion (GO:0032308)2.62898997
91transcription elongation from RNA polymerase I promoter (GO:0006362)2.62811469
92DNA recombination (GO:0006310)2.61400235
93somatic diversification of immunoglobulins (GO:0016445)2.59823944
94erythrocyte development (GO:0048821)2.59592957
95membrane protein intracellular domain proteolysis (GO:0031293)2.59311973
96nuclear pore complex assembly (GO:0051292)2.56552392
97negative regulation of telomere maintenance (GO:0032205)2.56186974
98striated muscle atrophy (GO:0014891)2.56081701
99response to UV-C (GO:0010225)2.54988630
100DNA replication initiation (GO:0006270)2.53166941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48205420
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.97892910
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75210951
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70860964
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.25277327
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25236323
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.09411709
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.74314706
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.68410218
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57172338
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.48148402
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.39887962
13VDR_22108803_ChIP-Seq_LS180_Human2.39217745
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.38066493
15ELK1_19687146_ChIP-ChIP_HELA_Human2.37185587
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35545574
17VDR_23849224_ChIP-Seq_CD4+_Human2.25438721
18PADI4_21655091_ChIP-ChIP_MCF-7_Human2.22837504
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16097137
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11768916
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.09500598
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.08011733
23AR_21572438_ChIP-Seq_LNCaP_Human2.07129461
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05123725
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03310706
26IGF1R_20145208_ChIP-Seq_DFB_Human2.01464412
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00116308
28IRF1_19129219_ChIP-ChIP_H3396_Human1.93097108
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92192669
30EWS_26573619_Chip-Seq_HEK293_Human1.84332480
31FOXP3_21729870_ChIP-Seq_TREG_Human1.83790558
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81611094
33MYC_18940864_ChIP-ChIP_HL60_Human1.80849491
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77882326
35SCL_19346495_ChIP-Seq_HPC-7_Human1.74662461
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74119737
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72327979
38GATA1_22025678_ChIP-Seq_K562_Human1.65852926
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62447276
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59360323
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57912064
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55560884
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53377386
44ER_23166858_ChIP-Seq_MCF-7_Human1.50760210
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45398338
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44348420
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40459625
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.36205118
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34247790
50KDM5A_27292631_Chip-Seq_BREAST_Human1.30822809
51EGR1_19032775_ChIP-ChIP_M12_Human1.30432174
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.30307439
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30001559
54FUS_26573619_Chip-Seq_HEK293_Human1.27338899
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25638682
56GABP_19822575_ChIP-Seq_HepG2_Human1.24147855
57ZNF274_21170338_ChIP-Seq_K562_Hela1.23761610
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20568930
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17739831
60DCP1A_22483619_ChIP-Seq_HELA_Human1.16424850
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14072046
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08364070
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.08233218
64TP53_22573176_ChIP-Seq_HFKS_Human1.07942674
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06000869
66TTF2_22483619_ChIP-Seq_HELA_Human1.05734531
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03661126
68ZNF263_19887448_ChIP-Seq_K562_Human1.02196131
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00845280
70XRN2_22483619_ChIP-Seq_HELA_Human0.99497753
71AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97377266
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96754090
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95932284
74ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94955046
75STAT1_20625510_ChIP-Seq_HELA_Human0.94375402
76AR_20517297_ChIP-Seq_VCAP_Human0.94283005
77NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92702728
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92105791
79NCOR1_26117541_ChIP-Seq_K562_Human0.91020948
80KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89372114
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89271288
82NCOR_22424771_ChIP-Seq_293T_Human0.88640164
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88607614
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.86035379
85CBP_20019798_ChIP-Seq_JUKART_Human0.85757361
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85757361
87MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85348079
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.85137747
89NANOG_19829295_ChIP-Seq_ESCs_Human0.84727618
90SOX2_19829295_ChIP-Seq_ESCs_Human0.84727618
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84586689
92AR_21909140_ChIP-Seq_LNCAP_Human0.83103734
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82373474
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81163772
95STAT3_23295773_ChIP-Seq_U87_Human0.80450391
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79693132
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.78111650
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77830766
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77528161
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.76949966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.23392506
2MP0008877_abnormal_DNA_methylation4.58039407
3MP0010094_abnormal_chromosome_stability4.02261656
4MP0008995_early_reproductive_senescence3.80260495
5MP0008058_abnormal_DNA_repair3.42635720
6MP0003123_paternal_imprinting3.40918437
7MP0003786_premature_aging3.06522830
8MP0002396_abnormal_hematopoietic_system2.69211154
9MP0009697_abnormal_copulation2.64571583
10MP0001986_abnormal_taste_sensitivity2.62751782
11MP0006035_abnormal_mitochondrial_morpho2.55257915
12MP0008057_abnormal_DNA_replication2.49109782
13MP0003195_calcinosis2.33293026
14MP0006036_abnormal_mitochondrial_physio2.26156540
15MP0001545_abnormal_hematopoietic_system2.23554987
16MP0005397_hematopoietic_system_phenotyp2.23554987
17MP0005083_abnormal_biliary_tract2.20489893
18MP0003111_abnormal_nucleus_morphology2.18332386
19MP0000427_abnormal_hair_cycle1.85639314
20MP0005167_abnormal_blood-brain_barrier1.82016237
21MP0001502_abnormal_circadian_rhythm1.81726167
22MP0003718_maternal_effect1.80962143
23MP0003121_genomic_imprinting1.76490619
24MP0006292_abnormal_olfactory_placode1.74326390
25MP0008775_abnormal_heart_ventricle1.72810409
26MP0003693_abnormal_embryo_hatching1.68021953
27MP0001727_abnormal_embryo_implantation1.57674266
28MP0008872_abnormal_physiological_respon1.53372765
29MP0003656_abnormal_erythrocyte_physiolo1.51701799
30MP0002160_abnormal_reproductive_system1.51002801
31MP0003122_maternal_imprinting1.50481231
32MP0003077_abnormal_cell_cycle1.42490162
33MP0002638_abnormal_pupillary_reflex1.39539346
34MP0006072_abnormal_retinal_apoptosis1.36115703
35MP0008007_abnormal_cellular_replicative1.33379484
36MP0002132_abnormal_respiratory_system1.30880900
37MP0008875_abnormal_xenobiotic_pharmacok1.26795242
38MP0005377_hearing/vestibular/ear_phenot1.26642775
39MP0003878_abnormal_ear_physiology1.26642775
40MP0004215_abnormal_myocardial_fiber1.26500209
41MP0000013_abnormal_adipose_tissue1.24300818
42MP0001929_abnormal_gametogenesis1.22044342
43MP0005075_abnormal_melanosome_morpholog1.21912322
44MP0010307_abnormal_tumor_latency1.21167796
45MP0005174_abnormal_tail_pigmentation1.21133412
46MP0003943_abnormal_hepatobiliary_system1.19004130
47MP0000372_irregular_coat_pigmentation1.18041781
48MP0002210_abnormal_sex_determination1.17413175
49MP0000678_abnormal_parathyroid_gland1.14190139
50MP0000015_abnormal_ear_pigmentation1.14105437
51MP0000358_abnormal_cell_content/1.11458823
52MP0002095_abnormal_skin_pigmentation1.10497658
53MP0000313_abnormal_cell_death1.06936005
54MP0004043_abnormal_pH_regulation1.05763979
55MP0003950_abnormal_plasma_membrane1.02995217
56MP0001697_abnormal_embryo_size1.01910492
57MP0004084_abnormal_cardiac_muscle1.01607046
58MP0003186_abnormal_redox_activity1.00136832
59MP0005646_abnormal_pituitary_gland0.99669050
60MP0001145_abnormal_male_reproductive0.97368272
61MP0000653_abnormal_sex_gland0.95135212
62MP0004957_abnormal_blastocyst_morpholog0.93683447
63MP0005645_abnormal_hypothalamus_physiol0.91891184
64MP0001881_abnormal_mammary_gland0.89534710
65MP0009703_decreased_birth_body0.88247389
66MP0001661_extended_life_span0.86763564
67MP0005464_abnormal_platelet_physiology0.86275343
68MP0001293_anophthalmia0.85957091
69MP0009046_muscle_twitch0.85578320
70MP0005551_abnormal_eye_electrophysiolog0.83746268
71MP0004133_heterotaxia0.83383779
72MP0001730_embryonic_growth_arrest0.82426611
73MP0003698_abnormal_male_reproductive0.81937460
74MP0005266_abnormal_metabolism0.80865599
75MP0005647_abnormal_sex_gland0.79863194
76MP0001486_abnormal_startle_reflex0.79012590
77MP0002139_abnormal_hepatobiliary_system0.77948635
78MP0005389_reproductive_system_phenotype0.76853158
79MP0005253_abnormal_eye_physiology0.76178584
80MP0008961_abnormal_basal_metabolism0.73103504
81MP0005085_abnormal_gallbladder_physiolo0.72609687
82MP0008932_abnormal_embryonic_tissue0.72472433
83MP0003646_muscle_fatigue0.72070392
84MP0004264_abnormal_extraembryonic_tissu0.71898754
85MP0002019_abnormal_tumor_incidence0.69560836
86MP0001853_heart_inflammation0.68630377
87MP0009379_abnormal_foot_pigmentation0.67267424
88MP0000631_abnormal_neuroendocrine_gland0.63236633
89MP0004019_abnormal_vitamin_homeostasis0.61082381
90MP0005451_abnormal_body_composition0.61052116
91MP0002084_abnormal_developmental_patter0.60917482
92MP0003806_abnormal_nucleotide_metabolis0.60871141
93MP0003252_abnormal_bile_duct0.60610828
94MP0003303_peritoneal_inflammation0.60323041
95MP0002332_abnormal_exercise_endurance0.57503773
96MP0003984_embryonic_growth_retardation0.57456363
97MP0009765_abnormal_xenobiotic_induced0.56008719
98MP0003724_increased_susceptibility_to0.55510602
99MP0000516_abnormal_urinary_system0.55121239
100MP0005367_renal/urinary_system_phenotyp0.55121239

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)6.98195379
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.79511840
3Abnormality of chromosome stability (HP:0003220)4.74004717
4Aplasia/Hypoplasia of the uvula (HP:0010293)4.34282092
5Congenital stationary night blindness (HP:0007642)4.30951056
6Meckel diverticulum (HP:0002245)4.15976951
7Abnormality of the ileum (HP:0001549)3.84682246
8Abnormality of the preputium (HP:0100587)3.74745054
9Small intestinal stenosis (HP:0012848)3.68799877
10Duodenal stenosis (HP:0100867)3.68799877
11Central scotoma (HP:0000603)3.45087920
12Thrombocytosis (HP:0001894)3.28617971
13Eosinophilia (HP:0001880)3.21248970
14Clubbing of toes (HP:0100760)3.17499537
15Pancreatic fibrosis (HP:0100732)3.02956462
16Decreased central vision (HP:0007663)2.98957238
17Nephronophthisis (HP:0000090)2.96992760
18Abnormality of the duodenum (HP:0002246)2.92437219
19Granulocytopenia (HP:0001913)2.88195634
20Pancreatic cysts (HP:0001737)2.85894142
21Abnormality of the heme biosynthetic pathway (HP:0010472)2.83698567
22Constricted visual fields (HP:0001133)2.83310626
23Birth length less than 3rd percentile (HP:0003561)2.81802233
24Abnormality of the renal medulla (HP:0100957)2.77183646
25Dyschromatopsia (HP:0007641)2.76047705
26Abnormality of the carotid arteries (HP:0005344)2.74314035
27True hermaphroditism (HP:0010459)2.73059752
28Cone-rod dystrophy (HP:0000548)2.68388966
29Biliary tract neoplasm (HP:0100574)2.56805376
30Neoplasm of the small intestine (HP:0100833)2.53862407
31Arteriovenous malformation (HP:0100026)2.49157071
32Type II lissencephaly (HP:0007260)2.48776860
33Myelodysplasia (HP:0002863)2.46436496
34Acute encephalopathy (HP:0006846)2.45681530
35Periodontitis (HP:0000704)2.40667934
36Progressive muscle weakness (HP:0003323)2.36253276
37Sloping forehead (HP:0000340)2.35531614
38Attenuation of retinal blood vessels (HP:0007843)2.31549730
39Rhabdomyosarcoma (HP:0002859)2.29986077
40Sclerocornea (HP:0000647)2.29542998
41Progressive macrocephaly (HP:0004481)2.27860587
42Optic disc pallor (HP:0000543)2.25438939
43Dyskinesia (HP:0100660)2.24896093
44Absent thumb (HP:0009777)2.18613405
45Abnormality of eosinophils (HP:0001879)2.14985394
46Duplicated collecting system (HP:0000081)2.13226216
47Type I transferrin isoform profile (HP:0003642)2.12938490
48Neoplasm of the rectum (HP:0100743)2.12129448
49Neurodegeneration (HP:0002180)2.11612231
50Short middle phalanx of the 5th finger (HP:0004220)2.09209800
51Increased CSF lactate (HP:0002490)2.08229875
52Scotoma (HP:0000575)2.06363439
53Poikilocytosis (HP:0004447)2.06218469
54Hepatocellular necrosis (HP:0001404)2.06175818
55Cerebellar dysplasia (HP:0007033)2.05468541
56Acanthocytosis (HP:0001927)2.04670105
57Acute myeloid leukemia (HP:0004808)2.04261355
58Acute necrotizing encephalopathy (HP:0006965)2.04259391
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.04214348
60Ectopic kidney (HP:0000086)2.03963354
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03718672
62Abnormal protein N-linked glycosylation (HP:0012347)2.03718672
63Abnormal protein glycosylation (HP:0012346)2.03718672
64Abnormal glycosylation (HP:0012345)2.03718672
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03556263
66Hypoplasia of the pons (HP:0012110)2.03458784
67Genetic anticipation (HP:0003743)2.01588900
68Oligohydramnios (HP:0001562)2.00863934
69Macular degeneration (HP:0000608)1.98471128
70Increased serum lactate (HP:0002151)1.97971358
71Pigmentary retinal degeneration (HP:0001146)1.97683274
72Abnormality of the pons (HP:0007361)1.96745034
73Abnormality of midbrain morphology (HP:0002418)1.96576926
74Molar tooth sign on MRI (HP:0002419)1.96576926
75Abnormality of macular pigmentation (HP:0008002)1.95707937
76Nephroblastoma (Wilms tumor) (HP:0002667)1.94404721
77Progressive inability to walk (HP:0002505)1.92888805
78Ureteral duplication (HP:0000073)1.91830938
79Abnormality of the renal cortex (HP:0011035)1.91248847
80Abnormality of the renal collecting system (HP:0004742)1.90912331
81Bone marrow hypocellularity (HP:0005528)1.90213092
82Autoimmune thrombocytopenia (HP:0001973)1.89129877
83Hyperthyroidism (HP:0000836)1.86899671
84Astigmatism (HP:0000483)1.86776755
85Keratoconus (HP:0000563)1.85685329
86Increased corneal curvature (HP:0100692)1.85685329
87Reduced antithrombin III activity (HP:0001976)1.85653966
88Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83681492
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83681492
903-Methylglutaconic aciduria (HP:0003535)1.83664018
91Fair hair (HP:0002286)1.83572455
92Pili torti (HP:0003777)1.83280732
93Renal cortical cysts (HP:0000803)1.82404064
94Abnormality of B cell number (HP:0010975)1.82395077
95Embryonal renal neoplasm (HP:0011794)1.81978869
96Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81177187
97Mitochondrial inheritance (HP:0001427)1.81161485
98Triphalangeal thumb (HP:0001199)1.80750901
99Bile duct proliferation (HP:0001408)1.77552930
100Abnormal biliary tract physiology (HP:0012439)1.77552930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.00958641
2MST43.39258276
3PIK3CG3.11745024
4FRK2.92575634
5PDK22.91905131
6PBK2.66908870
7SRPK12.52399781
8NUAK12.48771628
9TNIK2.43052978
10CSNK1G32.28061632
11PIK3CA2.24464555
12STK162.18005523
13CSNK1A1L2.16378211
14TTK2.10752262
15CCNB12.06034983
16PLK41.99128120
17IRAK11.93623150
18CDK31.81455512
19ZAK1.76051109
20CSNK1G21.75314376
21TRPM71.69364828
22CSNK1G11.66180108
23ERBB31.63960452
24MKNK11.63704626
25MKNK21.63550211
26BRSK21.61935690
27IRAK31.56855459
28IRAK21.55660699
29EIF2AK11.51782559
30CHEK21.48592971
31ATR1.43860725
32CDC71.36225778
33BUB11.33073667
34BMPR1B1.23473271
35BMPR21.14806657
36ACVR1B1.11928382
37RIPK41.11672139
38NEK21.10419294
39CAMK1D1.07886111
40TSSK61.07401505
41PLK31.04512156
42WEE10.99536447
43PINK10.98714157
44CDK190.95096063
45NME10.92100898
46PLK10.91163779
47CLK10.88902444
48MAP3K40.87273926
49TLK10.81572249
50RPS6KB20.81137614
51ATM0.77429658
52KIT0.74473806
53VRK10.74157276
54IRAK40.59802918
55MST1R0.58261173
56CSNK2A20.56640585
57CSNK1E0.56459544
58AURKB0.54801076
59OBSCN0.54001288
60LATS10.53321893
61ERBB40.52969158
62MATK0.50721905
63CDK90.50409112
64CHEK10.50129136
65ADRBK20.49243740
66WNK40.47205676
67CSNK2A10.47121635
68GRK10.46922238
69TEC0.46299756
70CSNK1D0.46003141
71RPS6KA40.45215590
72DAPK20.44580249
73RAF10.44093153
74PTK2B0.43269389
75PRKG20.39886035
76PTK60.39673068
77PRKDC0.39049100
78TGFBR10.37763275
79PLK20.37538912
80CDK10.36213631
81FLT30.36170865
82PRKAA20.35846553
83FGFR10.35609128
84BMX0.35073984
85PRKCQ0.34953629
86CDK20.34384128
87TYK20.31824337
88KSR20.31034371
89PHKG10.30826378
90PHKG20.30826378
91PRKAA10.29842145
92CSNK1A10.28447759
93STK40.27575152
94NEK10.27057564
95CAMK1G0.25996343
96CDK70.25846364
97GSK3B0.24258890
98CAMKK20.23504073
99VRK20.23319510
100CDK40.23191643

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034505.75106122
2Homologous recombination_Homo sapiens_hsa034405.10508056
3Fanconi anemia pathway_Homo sapiens_hsa034603.85387648
4Olfactory transduction_Homo sapiens_hsa047403.65979009
5Mismatch repair_Homo sapiens_hsa034303.07230593
6DNA replication_Homo sapiens_hsa030302.74597009
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.64687864
8One carbon pool by folate_Homo sapiens_hsa006702.53445865
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48823922
10Base excision repair_Homo sapiens_hsa034102.34508156
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.19835605
12Nucleotide excision repair_Homo sapiens_hsa034202.09289319
13Oxidative phosphorylation_Homo sapiens_hsa001902.08098139
14Ribosome_Homo sapiens_hsa030101.89587567
15RNA polymerase_Homo sapiens_hsa030201.88213259
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83098282
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.80091797
18Fatty acid biosynthesis_Homo sapiens_hsa000611.77196253
19Ether lipid metabolism_Homo sapiens_hsa005651.64356975
20RNA transport_Homo sapiens_hsa030131.58805942
21Parkinsons disease_Homo sapiens_hsa050121.51903999
22Propanoate metabolism_Homo sapiens_hsa006401.51085680
23Spliceosome_Homo sapiens_hsa030401.50627681
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47832474
25Pyrimidine metabolism_Homo sapiens_hsa002401.44532595
26Basal transcription factors_Homo sapiens_hsa030221.44287787
27Butanoate metabolism_Homo sapiens_hsa006501.36249472
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26069753
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.23430147
30Huntingtons disease_Homo sapiens_hsa050161.15376317
31Pyruvate metabolism_Homo sapiens_hsa006201.13102032
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13000746
33Fatty acid metabolism_Homo sapiens_hsa012121.12603415
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11268545
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08427380
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08144225
37Purine metabolism_Homo sapiens_hsa002301.07453698
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06928865
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00179088
40Alzheimers disease_Homo sapiens_hsa050100.93904795
41RNA degradation_Homo sapiens_hsa030180.91741332
42Linoleic acid metabolism_Homo sapiens_hsa005910.91243034
43Selenocompound metabolism_Homo sapiens_hsa004500.90382837
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84380404
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83698994
46Proteasome_Homo sapiens_hsa030500.82658023
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82053438
48Cell cycle_Homo sapiens_hsa041100.78929542
49Peroxisome_Homo sapiens_hsa041460.74866858
50Collecting duct acid secretion_Homo sapiens_hsa049660.74180295
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73370253
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69533013
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.68789088
54Metabolic pathways_Homo sapiens_hsa011000.65236700
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64661823
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.63843673
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61246696
58Folate biosynthesis_Homo sapiens_hsa007900.59122224
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59119677
60Carbon metabolism_Homo sapiens_hsa012000.57114819
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45494734
62Biosynthesis of amino acids_Homo sapiens_hsa012300.44788231
63Cardiac muscle contraction_Homo sapiens_hsa042600.38252441
64Inositol phosphate metabolism_Homo sapiens_hsa005620.35372257
65Taste transduction_Homo sapiens_hsa047420.34050949
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.33925375
67Vitamin B6 metabolism_Homo sapiens_hsa007500.33809859
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.31099213
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31095528
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29919099
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29879056
72Fatty acid degradation_Homo sapiens_hsa000710.29836001
73Steroid biosynthesis_Homo sapiens_hsa001000.29471168
74Oocyte meiosis_Homo sapiens_hsa041140.29100782
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28641980
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26782597
77Nitrogen metabolism_Homo sapiens_hsa009100.25290816
78Mineral absorption_Homo sapiens_hsa049780.24370796
79Type II diabetes mellitus_Homo sapiens_hsa049300.22803353
80Platelet activation_Homo sapiens_hsa046110.21751291
81Acute myeloid leukemia_Homo sapiens_hsa052210.21700351
82Systemic lupus erythematosus_Homo sapiens_hsa053220.20696802
83Ovarian steroidogenesis_Homo sapiens_hsa049130.19512347
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19435129
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.19316577
86mRNA surveillance pathway_Homo sapiens_hsa030150.17578196
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17227604
88p53 signaling pathway_Homo sapiens_hsa041150.15850857
89Sphingolipid metabolism_Homo sapiens_hsa006000.13637357
90Glutathione metabolism_Homo sapiens_hsa004800.13033751
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12667984
92N-Glycan biosynthesis_Homo sapiens_hsa005100.12267104
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.11931019
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11700405
95mTOR signaling pathway_Homo sapiens_hsa041500.08934032
96Caffeine metabolism_Homo sapiens_hsa002320.08262178
97Fat digestion and absorption_Homo sapiens_hsa049750.06961227
98Renin-angiotensin system_Homo sapiens_hsa046140.06344355
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06268799
100Long-term depression_Homo sapiens_hsa047300.04773721

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