ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	centriole assembly (GO:0098534)	9.44359535
2	sensory perception of smell (GO:0007608)	7.87341358
3	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	7.04192807
4	nuclear pore complex assembly (GO:0051292)	6.68061635
5	keratinocyte proliferation (GO:0043616)	6.02007380
6	nuclear pore organization (GO:0006999)	5.85661688
7	histone H3-K9 methylation (GO:0051567)	5.68515997
8	replicative senescence (GO:0090399)	4.98302235
9	pore complex assembly (GO:0046931)	4.83594174
10	regulation of centriole replication (GO:0046599)	4.78332917
11	detection of chemical stimulus involved in sensory perception (GO:0050907)	4.68182842
12	protein K6-linked ubiquitination (GO:0085020)	4.65409483
13	histone H3-K9 modification (GO:0061647)	4.57813380
14	positive regulation of histone H3-K4 methylation (GO:0051571)	4.53942255
15	regulation of DNA endoreduplication (GO:0032875)	4.38935735
16	sensory perception of chemical stimulus (GO:0007606)	4.35109806
17	response to UV-C (GO:0010225)	4.28718291
18	regulation of translational fidelity (GO:0006450)	4.19110648
19	cilium or flagellum-dependent cell motility (GO:0001539)	4.09272476
20	DNA replication checkpoint (GO:0000076)	4.07771207
21	DNA replication-dependent nucleosome organization (GO:0034723)	4.02224062
22	DNA replication-dependent nucleosome assembly (GO:0006335)	4.02224062
23	microtubule depolymerization (GO:0007019)	3.92690294
24	hepatocyte differentiation (GO:0070365)	3.82966858
25	regulation of histone H3-K4 methylation (GO:0051569)	3.81573148
26	heterochromatin organization (GO:0070828)	3.80779494
27	oocyte maturation (GO:0001556)	3.80198980
28	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.78599406
29	male meiosis I (GO:0007141)	3.77973539
30	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.67998910
31	peptidyl-threonine dephosphorylation (GO:0035970)	3.65883568
32	regulation of histone H3-K9 methylation (GO:0051570)	3.60443668
33	ubiquinone biosynthetic process (GO:0006744)	3.59965295
34	DNA topological change (GO:0006265)	3.54769846
35	chromatin remodeling at centromere (GO:0031055)	3.51752967
36	regulation of centrosome cycle (GO:0046605)	3.49115114
37	DNA replication initiation (GO:0006270)	3.49076398
38	inositol phosphate dephosphorylation (GO:0046855)	3.45071339
39	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.45071339
40	mitotic sister chromatid cohesion (GO:0007064)	3.43530735
41	ubiquinone metabolic process (GO:0006743)	3.34870650
42	rRNA catabolic process (GO:0016075)	3.34668633
43	synapsis (GO:0007129)	3.33251868
44	retinal cone cell development (GO:0046549)	3.29901076
45	pseudouridine synthesis (GO:0001522)	3.28798997
46	vitamin A metabolic process (GO:0006776)	3.27185907
47	meiosis I (GO:0007127)	3.25519279
48	mitotic nuclear envelope disassembly (GO:0007077)	3.24683864
49	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.24296675
50	terpenoid biosynthetic process (GO:0016114)	3.20248625
51	peptidyl-histidine modification (GO:0018202)	3.19213151
52	inositol phosphate catabolic process (GO:0071545)	3.18653513
53	protein localization to kinetochore (GO:0034501)	3.17941030
54	CENP-A containing nucleosome assembly (GO:0034080)	3.17745270
55	regulation of translational termination (GO:0006449)	3.17620741
56	diterpenoid biosynthetic process (GO:0016102)	3.16951385
57	detection of chemical stimulus (GO:0009593)	3.15286685
58	centrosome duplication (GO:0051298)	3.15137232
59	quinone biosynthetic process (GO:1901663)	3.13233615
60	regulation of centrosome duplication (GO:0010824)	3.08729690
61	DNA-dependent DNA replication (GO:0006261)	3.05712425
62	regulation of RNA export from nucleus (GO:0046831)	3.04342882
63	positive regulation of histone methylation (GO:0031062)	3.03056824
64	DNA replication-independent nucleosome organization (GO:0034724)	3.01385777
65	DNA replication-independent nucleosome assembly (GO:0006336)	3.01385777
66	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.00222992
67	amino acid activation (GO:0043038)	2.96848388
68	tRNA aminoacylation (GO:0043039)	2.96848388
69	mitotic spindle checkpoint (GO:0071174)	2.95845704
70	IMP biosynthetic process (GO:0006188)	2.93130434
71	nuclear envelope disassembly (GO:0051081)	2.93042897
72	membrane disassembly (GO:0030397)	2.93042897
73	negative regulation of organelle assembly (GO:1902116)	2.91479668
74	maturation of 5.8S rRNA (GO:0000460)	2.91029655
75	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.90602066
76	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.89898748
77	interkinetic nuclear migration (GO:0022027)	2.89627034
78	protein localization to chromosome, centromeric region (GO:0071459)	2.89494406
79	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.88170644
80	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.87155772
81	maturation of SSU-rRNA (GO:0030490)	2.86460600
82	sister chromatid cohesion (GO:0007062)	2.85906258
83	double-strand break repair via homologous recombination (GO:0000724)	2.82473034
84	mitotic spindle assembly checkpoint (GO:0007094)	2.82453680
85	mitochondrial DNA replication (GO:0006264)	2.81987705
86	microtubule polymerization or depolymerization (GO:0031109)	2.81312879
87	spindle assembly checkpoint (GO:0071173)	2.81141840
88	mitotic G2/M transition checkpoint (GO:0044818)	2.80745660
89	negative regulation of chromosome segregation (GO:0051985)	2.80226400
90	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.79527238
91	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.79527238
92	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.79527238
93	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.79527238
94	negative regulation of sister chromatid segregation (GO:0033046)	2.79527238
95	phosphorelay signal transduction system (GO:0000160)	2.79069710
96	regulation of DNA-dependent DNA replication (GO:0090329)	2.77906638
97	spindle checkpoint (GO:0031577)	2.77744038
98	recombinational repair (GO:0000725)	2.76307940
99	chromatin assembly (GO:0031497)	2.76298803
100	motile cilium assembly (GO:0044458)	16.6706375

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.34171572
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.14365040
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.23525563
4	VDR_22108803_ChIP-Seq_LS180_Human	2.97252272
5	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.96034994
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.92239124
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.87505392
8	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.72986631
9	GATA1_22025678_ChIP-Seq_K562_Human	2.60861674
10	EWS_26573619_Chip-Seq_HEK293_Human	2.47052789
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.41100374
12	AR_21909140_ChIP-Seq_LNCAP_Human	2.36435427
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34517238
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.31253728
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31146352
16	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.20034905
17	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.12884761
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09110217
19	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.01220364
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.00330325
21	E2F7_22180533_ChIP-Seq_HELA_Human	10.8722612
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.95787913
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.95304564
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.92608075
25	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.89454970
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.88484673
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86874226
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.73200809
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.70504106
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.68654783
31	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.66964842
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.66886056
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.65420466
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.65138979
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54803741
36	FUS_26573619_Chip-Seq_HEK293_Human	1.53107796
37	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.52334224
38	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.50662798
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.46970964
40	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.45128074
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.43904057
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40875635
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.38434137
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36757794
45	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35941702
46	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.33936681
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.31503977
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.30249508
49	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.26789723
50	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.26033621
51	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25214952
52	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.18422689
53	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.17398072
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.14090463
55	XRN2_22483619_ChIP-Seq_HELA_Human	1.09591832
56	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.09399219
57	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.08511990
58	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.06748718
59	ZNF263_19887448_ChIP-Seq_K562_Human	1.04933013
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04467058
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03301882
62	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.02911811
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02301987
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.98244926
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.98099595
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97217679
67	GABP_19822575_ChIP-Seq_HepG2_Human	0.96758216
68	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.93143665
69	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.92311278
70	IGF1R_20145208_ChIP-Seq_DFB_Human	0.89639934
71	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.89018962
72	NFYB_21822215_ChIP-Seq_K562_Human	0.88526090
73	PHF8_20622853_ChIP-Seq_HELA_Human	0.87476113
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.87012137
75	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.85346222
76	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.85237741
77	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.85058241
78	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.84756495
79	TBL1_22424771_ChIP-Seq_293T_Human	0.84564653
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83863953
81	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.83430566
82	NFYA_21822215_ChIP-Seq_K562_Human	0.83163854
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.82989708
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.82989708
85	TP53_16413492_ChIP-PET_HCT116_Human	0.82685528
86	TCF4_23295773_ChIP-Seq_U87_Human	0.82340058
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.80554991
88	STAT3_23295773_ChIP-Seq_U87_Human	0.80333222
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.79953148
90	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.79879348
91	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.79740981
92	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.79740981
93	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.79740981
94	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.79290001
95	ELF5_23300383_ChIP-Seq_T47D_Human	0.78398968
96	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.78072654
97	JUN_21703547_ChIP-Seq_K562_Human	0.77052546
98	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.76763700
99	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.76709947
100	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.76194762

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	5.51963824
2	MP0009697_abnormal_copulation	4.44175947
3	MP0003111_abnormal_nucleus_morphology	3.92793156
4	MP0010307_abnormal_tumor_latency	3.47596526
5	MP0002396_abnormal_hematopoietic_system	3.42571623
6	MP0008058_abnormal_DNA_repair	3.30927425
7	MP0003123_paternal_imprinting	3.28653177
8	MP0005451_abnormal_body_composition	2.94707606
9	MP0008057_abnormal_DNA_replication	2.89978818
10	MP0004957_abnormal_blastocyst_morpholog	2.87587031
11	MP0003077_abnormal_cell_cycle	2.85291508
12	MP0000678_abnormal_parathyroid_gland	2.84211019
13	MP0003786_premature_aging	2.71474753
14	MP0000427_abnormal_hair_cycle	2.63992883
15	MP0008007_abnormal_cellular_replicative	2.41012276
16	MP0005646_abnormal_pituitary_gland	2.38989503
17	MP0003718_maternal_effect	2.31820941
18	MP0003693_abnormal_embryo_hatching	2.29810939
19	MP0002009_preneoplasia	2.29151873
20	MP0003806_abnormal_nucleotide_metabolis	2.10259399
21	MP0008932_abnormal_embryonic_tissue	1.94667741
22	MP0004147_increased_porphyrin_level	1.82064033
23	MP0006292_abnormal_olfactory_placode	1.77316176
24	MP0002160_abnormal_reproductive_system	1.62531798
25	MP0008995_early_reproductive_senescence	1.56304593
26	MP0000350_abnormal_cell_proliferation	1.53072847
27	MP0003121_genomic_imprinting	1.50176063
28	MP0001661_extended_life_span	1.48667391
29	MP0006035_abnormal_mitochondrial_morpho	1.45272575
30	MP0003890_abnormal_embryonic-extraembry	1.43763192
31	MP0008877_abnormal_DNA_methylation	1.42785530
32	MP0004808_abnormal_hematopoietic_stem	1.41063886
33	MP0001873_stomach_inflammation	1.32507208
34	MP0001697_abnormal_embryo_size	1.30297255
35	MP0004145_abnormal_muscle_electrophysio	1.29676589
36	MP0002210_abnormal_sex_determination	1.28955321
37	MP0000313_abnormal_cell_death	1.24214187
38	MP0000631_abnormal_neuroendocrine_gland	1.24130810
39	MP0003943_abnormal_hepatobiliary_system	1.22334776
40	MP0001672_abnormal_embryogenesis/_devel	1.22103580
41	MP0005380_embryogenesis_phenotype	1.22103580
42	MP0001929_abnormal_gametogenesis	1.21463662
43	MP0004019_abnormal_vitamin_homeostasis	1.20592001
44	MP0005647_abnormal_sex_gland	1.20276986
45	MP0001730_embryonic_growth_arrest	1.14363347
46	MP0003656_abnormal_erythrocyte_physiolo	1.13878783
47	MP0003984_embryonic_growth_retardation	1.06028375
48	MP0005253_abnormal_eye_physiology	1.02256366
49	MP0003699_abnormal_female_reproductive	1.02120665
50	MP0006036_abnormal_mitochondrial_physio	0.99806251
51	MP0002088_abnormal_embryonic_growth/wei	0.98769232
52	MP0003936_abnormal_reproductive_system	0.96011742
53	MP0009703_decreased_birth_body	0.95221539
54	MP0002928_abnormal_bile_duct	0.94800748
55	MP0009046_muscle_twitch	0.94180153
56	MP0005389_reproductive_system_phenotype	0.92907443
57	MP0003937_abnormal_limbs/digits/tail_de	0.91950006
58	MP0005551_abnormal_eye_electrophysiolog	0.91622954
59	MP0004197_abnormal_fetal_growth/weight/	0.91602525
60	MP0000653_abnormal_sex_gland	0.90302974
61	MP0002084_abnormal_developmental_patter	0.90119324
62	MP0000358_abnormal_cell_content/	0.89700645
63	MP0001145_abnormal_male_reproductive	0.88165402
64	MP0002086_abnormal_extraembryonic_tissu	0.84631391
65	MP0005083_abnormal_biliary_tract	0.84576875
66	MP0005395_other_phenotype	0.83474795
67	MP0002970_abnormal_white_adipose	0.82994089
68	MP0002095_abnormal_skin_pigmentation	0.82811412
69	MP0003935_abnormal_craniofacial_develop	0.81721234
70	MP0003698_abnormal_male_reproductive	0.80212218
71	MP0008775_abnormal_heart_ventricle	0.79607247
72	MP0002269_muscular_atrophy	0.79379573
73	MP0001119_abnormal_female_reproductive	0.79304606
74	MP0009672_abnormal_birth_weight	0.79173566
75	MP0001881_abnormal_mammary_gland	0.79036832
76	MP0004264_abnormal_extraembryonic_tissu	0.78481577
77	MP0001293_anophthalmia	0.77809921
78	MP0002080_prenatal_lethality	0.77345490
79	MP0004215_abnormal_myocardial_fiber	0.76252247
80	MP0008770_decreased_survivor_rate	0.75875522
81	MP0001986_abnormal_taste_sensitivity	0.75782902
82	MP0009115_abnormal_fat_cell	0.75358406
83	MP0005085_abnormal_gallbladder_physiolo	0.74967145
84	MP0000383_abnormal_hair_follicle	0.70110403
85	MP0002085_abnormal_embryonic_tissue	0.69814242
86	MP0005408_hypopigmentation	0.69703879
87	MP0000627_abnormal_mammary_gland	0.69156635
88	MP0002877_abnormal_melanocyte_morpholog	0.68385249
89	MP0005397_hematopoietic_system_phenotyp	0.68014887
90	MP0001545_abnormal_hematopoietic_system	0.68014887
91	MP0005391_vision/eye_phenotype	0.67460172
92	MP0000639_abnormal_adrenal_gland	0.67034025
93	MP0003186_abnormal_redox_activity	0.66912056
94	MP0003868_abnormal_feces_composition	0.65532152
95	MP0002019_abnormal_tumor_incidence	0.64663924
96	MP0010352_gastrointestinal_tract_polyps	0.64157545
97	MP0002161_abnormal_fertility/fecundity	0.64052467
98	MP0003938_abnormal_ear_development	0.62259658
99	MP0002111_abnormal_tail_morphology	0.61915446
100	MP0010678_abnormal_skin_adnexa	0.61030563

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	7.50933862
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	7.19631909
3	Absent/shortened dynein arms (HP:0200106)	6.43091884
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.43091884
5	Flat cornea (HP:0007720)	4.80070579
6	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.46438523
7	Abnormality of chromosome stability (HP:0003220)	4.42004409
8	Abnormality of the preputium (HP:0100587)	4.39829438
9	Meckel diverticulum (HP:0002245)	4.07053253
10	Abnormality of the ileum (HP:0001549)	4.02164110
11	Acute lymphatic leukemia (HP:0006721)	4.00064687
12	Abnormal ciliary motility (HP:0012262)	3.91115657
13	Abnormal respiratory motile cilium physiology (HP:0012261)	3.69662425
14	Hypoplasia of the pons (HP:0012110)	3.62131828
15	Abnormality of the pons (HP:0007361)	3.54664871
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.50790768
17	Abnormal respiratory epithelium morphology (HP:0012253)	3.37743752
18	Abnormal respiratory motile cilium morphology (HP:0005938)	3.37743752
19	Small intestinal stenosis (HP:0012848)	3.33181206
20	Duodenal stenosis (HP:0100867)	3.33181206
21	Pheochromocytoma (HP:0002666)	3.26922974
22	Increased corneal curvature (HP:0100692)	3.20054383
23	Keratoconus (HP:0000563)	3.20054383
24	Clubbing of toes (HP:0100760)	3.19471327
25	Nephroblastoma (Wilms tumor) (HP:0002667)	3.12582859
26	Abnormality of the carotid arteries (HP:0005344)	3.05426900
27	Embryonal renal neoplasm (HP:0011794)	2.91965335
28	Acute myeloid leukemia (HP:0004808)	2.88668828
29	Neuroendocrine neoplasm (HP:0100634)	2.88622010
30	Cerebellar dysplasia (HP:0007033)	2.84842237
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.83504503
32	Abnormality of alanine metabolism (HP:0010916)	2.83504503
33	Hyperalaninemia (HP:0003348)	2.83504503
34	Impulsivity (HP:0100710)	2.77567682
35	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.69695182
36	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.69695182
37	Birth length less than 3rd percentile (HP:0003561)	2.67832519
38	Prostate neoplasm (HP:0100787)	2.60515447
39	Renal cortical cysts (HP:0000803)	2.58931895
40	Chronic hepatic failure (HP:0100626)	2.58070746
41	Truncal obesity (HP:0001956)	2.57489610
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.57254442
43	Sclerocornea (HP:0000647)	2.52774236
44	Myelodysplasia (HP:0002863)	2.49671196
45	Sloping forehead (HP:0000340)	2.47550483
46	Abnormality of the duodenum (HP:0002246)	2.47449984
47	Abnormality of the renal cortex (HP:0011035)	2.44101577
48	Progressive external ophthalmoplegia (HP:0000590)	2.41284091
49	Type II lissencephaly (HP:0007260)	2.41189197
50	Abnormal hemoglobin (HP:0011902)	2.33571292
51	Chronic bronchitis (HP:0004469)	2.33435317
52	Volvulus (HP:0002580)	2.30168660
53	Embryonal neoplasm (HP:0002898)	2.29559788
54	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.25669718
55	Rhinitis (HP:0012384)	2.18063166
56	Duplicated collecting system (HP:0000081)	2.16155110
57	Cafe-au-lait spot (HP:0000957)	2.15817261
58	Abnormality of the renal collecting system (HP:0004742)	2.12733547
59	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.11901508
60	Poikiloderma (HP:0001029)	2.11506501
61	Hyperglycinemia (HP:0002154)	2.07999123
62	Oligodactyly (hands) (HP:0001180)	2.05107042
63	Protruding tongue (HP:0010808)	2.01346387
64	Reticulocytopenia (HP:0001896)	1.99162767
65	Acanthocytosis (HP:0001927)	1.95644858
66	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.95387366
67	Absent thumb (HP:0009777)	1.94477414
68	Hyperglycinuria (HP:0003108)	1.94207949
69	Abnormality of the corticospinal tract (HP:0002492)	1.92132050
70	Arteriovenous malformation (HP:0100026)	1.91778085
71	Truncus arteriosus (HP:0001660)	1.91667508
72	Gaze-evoked nystagmus (HP:0000640)	1.90914754
73	Triphalangeal thumb (HP:0001199)	1.88500769
74	Choanal atresia (HP:0000453)	1.88449630
75	Increased serum pyruvate (HP:0003542)	1.86910326
76	Short thumb (HP:0009778)	1.81721623
77	Bone marrow hypocellularity (HP:0005528)	1.80636812
78	Astigmatism (HP:0000483)	1.80059948
79	Papillary thyroid carcinoma (HP:0002895)	1.78781128
80	Megalocornea (HP:0000485)	1.78078363
81	Pallor (HP:0000980)	1.77576361
82	Tubulointerstitial nephritis (HP:0001970)	1.77440756
83	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.76064546
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.70295059
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.69827502
86	Ectopic kidney (HP:0000086)	1.69028137
87	Septate vagina (HP:0001153)	1.68264977
88	Neoplasm of the peripheral nervous system (HP:0100007)	1.67758488
89	Obsessive-compulsive behavior (HP:0000722)	1.66266976
90	Abnormality of chromosome segregation (HP:0002916)	1.64747518
91	Abnormality of serum amino acid levels (HP:0003112)	1.62544959
92	Hand muscle atrophy (HP:0009130)	1.61064061
93	Abnormality of glycolysis (HP:0004366)	1.60295217
94	Bronchiectasis (HP:0002110)	1.60226359
95	Adrenal hypoplasia (HP:0000835)	1.58292351
96	Rhabdomyosarcoma (HP:0002859)	1.57762879
97	Horseshoe kidney (HP:0000085)	1.57684353
98	Increased nuchal translucency (HP:0010880)	1.57145774
99	Meningioma (HP:0002858)	1.56696107
100	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.55276161

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.42956773
2	TAOK3	3.64909830
3	TTK	3.63896175
4	BMPR1B	3.60201481
5	MKNK2	3.55853774
6	ACVR1B	3.27689605
7	TNIK	2.83783005
8	MKNK1	2.37670356
9	PBK	2.28596162
10	CHEK2	2.27509223
11	CCNB1	2.21474204
12	MST1R	2.02948752
13	WEE1	1.89366176
14	TSSK6	1.88121102
15	CDK7	1.88067998
16	SRPK1	1.81672095
17	EIF2AK1	1.79419321
18	BRSK2	1.76817710
19	NME1	1.70456482
20	BUB1	1.67376919
21	KSR2	1.65718287
22	CDC7	1.61093617
23	PLK1	1.59034168
24	PLK4	1.51843205
25	PINK1	1.50694486
26	ZAK	1.49839406
27	NEK1	1.49732698
28	EIF2AK3	1.45733468
29	NEK2	1.41854320
30	WNK4	1.40663046
31	NTRK3	1.38452425
32	TGFBR1	1.38140806
33	MAP3K2	1.34897979
34	ALK	1.30489882
35	MELK	1.29811456
36	STK39	1.29415991
37	STK10	1.27080549
38	ATR	1.26561193
39	CDK4	1.25773205
40	PLK3	1.21989794
41	FRK	1.17278012
42	RAF1	1.11640575
43	RIPK4	1.09428554
44	CASK	1.07161340
45	NME2	1.05963797
46	KSR1	1.05271717
47	CDK8	1.05149347
48	TRPM7	1.01524366
49	BRSK1	0.95648041
50	RPS6KB2	0.93685978
51	ATM	0.93378883
52	NEK6	0.91818908
53	MAP3K8	0.86908733
54	LATS1	0.83308860
55	AURKB	0.83273855
56	MET	0.76927247
57	STK3	0.74420796
58	BMPR2	0.73706899
59	CHEK1	0.72928400
60	EEF2K	0.71279666
61	YES1	0.69783368
62	STK16	0.69075308
63	CDK3	0.68608010
64	BRD4	0.67557571
65	CAMK1D	0.66639636
66	CDK12	0.66544409
67	VRK1	0.62742565
68	PDK2	0.61917117
69	WNK1	0.60968733
70	CSNK1A1L	0.60634730
71	AURKA	0.59672857
72	FGFR1	0.59020208
73	RPS6KA4	0.55587848
74	CLK1	0.53080079
75	CDK1	0.49851769
76	TRIM28	0.49832097
77	CSNK1E	0.49446401
78	CDK2	0.49156073
79	CSNK2A2	0.47372445
80	SCYL2	0.44337516
81	PRKCI	0.44110120
82	MAP2K1	0.42597359
83	NUAK1	0.41039442
84	MAPK10	0.40899730
85	MAP3K4	0.40217581
86	CSNK2A1	0.40101082
87	BMX	0.39785866
88	OXSR1	0.39587479
89	SGK1	0.39569136
90	PIM1	0.38423895
91	STK4	0.35969158
92	EIF2AK2	0.33828032
93	ADRBK1	0.33232187
94	MAP4K2	0.30047883
95	PRKDC	0.29415675
96	MAP3K13	0.28585209
97	AKT2	0.26396587
98	MARK3	0.26131042
99	ERBB3	0.25720478
100	ERBB4	0.24923587

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.79077482
2	Olfactory transduction_Homo sapiens_hsa04740	4.69918726
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.27577338
4	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.13809964
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.04590029
6	Fanconi anemia pathway_Homo sapiens_hsa03460	3.53222409
7	Non-homologous end-joining_Homo sapiens_hsa03450	3.30684109
8	Cell cycle_Homo sapiens_hsa04110	2.87856965
9	DNA replication_Homo sapiens_hsa03030	2.60366403
10	RNA degradation_Homo sapiens_hsa03018	2.44860259
11	RNA transport_Homo sapiens_hsa03013	2.35602908
12	Mismatch repair_Homo sapiens_hsa03430	2.33620997
13	One carbon pool by folate_Homo sapiens_hsa00670	2.31882460
14	Basal transcription factors_Homo sapiens_hsa03022	2.04172751
15	Ribosome_Homo sapiens_hsa03010	1.82426686
16	Spliceosome_Homo sapiens_hsa03040	1.80285850
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.76868362
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64791389
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.64174737
20	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.49819027
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.49586315
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48664755
23	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.47641990
24	RNA polymerase_Homo sapiens_hsa03020	1.21131185
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.19236079
26	mRNA surveillance pathway_Homo sapiens_hsa03015	1.18888144
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17332053
28	Oocyte meiosis_Homo sapiens_hsa04114	1.15576120
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09407154
30	Purine metabolism_Homo sapiens_hsa00230	1.05851624
31	Butanoate metabolism_Homo sapiens_hsa00650	1.05843706
32	Fatty acid metabolism_Homo sapiens_hsa01212	1.03284532
33	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.00867506
34	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92167246
35	Proteasome_Homo sapiens_hsa03050	0.88179082
36	p53 signaling pathway_Homo sapiens_hsa04115	0.83237424
37	Huntingtons disease_Homo sapiens_hsa05016	0.77961943
38	Steroid biosynthesis_Homo sapiens_hsa00100	0.75069758
39	Base excision repair_Homo sapiens_hsa03410	0.72582960
40	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.72118549
41	Thyroid cancer_Homo sapiens_hsa05216	0.69693115
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69642392
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.69468011
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67069171
45	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.63335733
46	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.60744836
47	ABC transporters_Homo sapiens_hsa02010	0.58826638
48	ErbB signaling pathway_Homo sapiens_hsa04012	0.55319772
49	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.54782742
50	Viral carcinogenesis_Homo sapiens_hsa05203	0.54292112
51	Nicotine addiction_Homo sapiens_hsa05033	0.53515222
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53511863
53	Retinol metabolism_Homo sapiens_hsa00830	0.53145769
54	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52974738
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.51747612
56	Propanoate metabolism_Homo sapiens_hsa00640	0.51131877
57	Taste transduction_Homo sapiens_hsa04742	0.49836585
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.47980077
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.46302483
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.46295932
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40517442
62	Pentose phosphate pathway_Homo sapiens_hsa00030	0.39944933
63	Metabolic pathways_Homo sapiens_hsa01100	0.36947960
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35440647
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.32835494
66	Pancreatic cancer_Homo sapiens_hsa05212	0.32581424
67	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.30617746
68	Linoleic acid metabolism_Homo sapiens_hsa00591	0.29749635
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.29241809
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28998257
71	Adherens junction_Homo sapiens_hsa04520	0.27267321
72	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.25742772
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25492589
74	MicroRNAs in cancer_Homo sapiens_hsa05206	0.24871297
75	Fatty acid degradation_Homo sapiens_hsa00071	0.24697499
76	Carbon metabolism_Homo sapiens_hsa01200	0.24303032
77	African trypanosomiasis_Homo sapiens_hsa05143	0.23108674
78	HTLV-I infection_Homo sapiens_hsa05166	0.22228406
79	Measles_Homo sapiens_hsa05162	0.22198651
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.21311253
81	Type II diabetes mellitus_Homo sapiens_hsa04930	0.21068525
82	Herpes simplex infection_Homo sapiens_hsa05168	0.20439242
83	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.20096543
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.19936942
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.19670682
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19594339
87	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.19462440
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.16921948
89	Peroxisome_Homo sapiens_hsa04146	0.16717001
90	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.16181049
91	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.14908531
92	Alcoholism_Homo sapiens_hsa05034	0.14689618
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.14503896
94	Caffeine metabolism_Homo sapiens_hsa00232	0.13018333
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.10457816
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.10019086
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.09378029
98	Lysine degradation_Homo sapiens_hsa00310	0.09042676
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.08684083
100	mTOR signaling pathway_Homo sapiens_hsa04150	0.08285131

OR51K1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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