OR52D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)9.05159445
2nuclear pore organization (GO:0006999)7.87712344
3pore complex assembly (GO:0046931)6.83071810
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.69025814
5microtubule depolymerization (GO:0007019)5.58905537
6peptidyl-threonine dephosphorylation (GO:0035970)5.21402133
7chromosome condensation (GO:0030261)5.06863786
8regulation of centriole replication (GO:0046599)5.05033529
9regulation of translational fidelity (GO:0006450)4.99839426
10DNA packaging (GO:0006323)4.82986702
11* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.81583702
12DNA replication checkpoint (GO:0000076)4.77883006
13mitotic chromosome condensation (GO:0007076)4.74287210
14mitotic nuclear envelope disassembly (GO:0007077)4.58611091
15sister chromatid segregation (GO:0000819)4.56898377
16mitotic sister chromatid segregation (GO:0000070)4.56416838
17centriole replication (GO:0007099)4.47186143
18regulation of RNA export from nucleus (GO:0046831)4.35264021
19nuclear envelope disassembly (GO:0051081)4.33416786
20membrane disassembly (GO:0030397)4.33416786
21mitotic metaphase plate congression (GO:0007080)4.24344697
22microtubule polymerization or depolymerization (GO:0031109)4.23943477
23protein localization to chromosome, centromeric region (GO:0071459)4.23829868
24regulation of mitotic spindle organization (GO:0060236)4.23205968
25mitotic sister chromatid cohesion (GO:0007064)4.18943882
26DNA unwinding involved in DNA replication (GO:0006268)4.18532064
27regulation of centrosome cycle (GO:0046605)4.09606805
28* sensory perception of smell (GO:0007608)4.08654602
29synapsis (GO:0007129)3.97696009
30centriole assembly (GO:0098534)3.96421353
31DNA topological change (GO:0006265)3.90816941
32protein localization to kinetochore (GO:0034501)3.90071105
33DNA strand elongation involved in DNA replication (GO:0006271)3.88873669
34DNA replication initiation (GO:0006270)3.83861169
35DNA conformation change (GO:0071103)3.77548880
36regulation of double-strand break repair via homologous recombination (GO:0010569)3.76346175
37regulation of nucleobase-containing compound transport (GO:0032239)3.75632242
38DNA strand elongation (GO:0022616)3.74611738
39non-recombinational repair (GO:0000726)3.74032063
40double-strand break repair via nonhomologous end joining (GO:0006303)3.74032063
41regulation of histone H3-K27 methylation (GO:0061085)3.69301029
42metaphase plate congression (GO:0051310)3.66409867
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61343774
44histone H3-K9 demethylation (GO:0033169)3.61223698
45folic acid-containing compound biosynthetic process (GO:0009396)3.59647505
46regulation of histone H3-K4 methylation (GO:0051569)3.59122413
47regulation of centrosome duplication (GO:0010824)3.58375480
48regulation of spindle organization (GO:0090224)3.54497343
49positive regulation of chromosome segregation (GO:0051984)3.53997351
50regulation of chromosome segregation (GO:0051983)3.49576451
51regulation of histone H3-K9 methylation (GO:0051570)3.48586111
52ribosome assembly (GO:0042255)3.48192031
53positive regulation of mitotic sister chromatid separation (GO:1901970)3.46688962
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.46688962
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.46688962
56meiotic chromosome segregation (GO:0045132)3.43533325
57positive regulation of histone H3-K4 methylation (GO:0051571)3.42889036
58diterpenoid biosynthetic process (GO:0016102)3.41316504
59rRNA methylation (GO:0031167)3.41177768
60negative regulation of histone methylation (GO:0031061)3.38676971
61chromosome segregation (GO:0007059)3.37927173
62resolution of meiotic recombination intermediates (GO:0000712)3.37459460
63protein localization to chromosome (GO:0034502)3.37360370
64tRNA aminoacylation for protein translation (GO:0006418)3.36446743
65nucleus organization (GO:0006997)3.36304690
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.27554724
67tRNA aminoacylation (GO:0043039)3.26578495
68amino acid activation (GO:0043038)3.26578495
69telomere maintenance via semi-conservative replication (GO:0032201)3.25021421
70formation of translation preinitiation complex (GO:0001731)3.21177632
71binding of sperm to zona pellucida (GO:0007339)3.16435784
72mitotic G2/M transition checkpoint (GO:0044818)3.15330889
73regulation of translational elongation (GO:0006448)3.13764489
74DNA geometric change (GO:0032392)3.13657822
75DNA duplex unwinding (GO:0032508)3.13590126
76centrosome duplication (GO:0051298)3.12148980
77mitotic recombination (GO:0006312)3.11781910
78nuclear envelope organization (GO:0006998)3.11664978
79kinetochore organization (GO:0051383)3.09531267
80positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.08995615
81DNA synthesis involved in DNA repair (GO:0000731)3.07154436
82telomere maintenance via recombination (GO:0000722)3.06759040
83* detection of chemical stimulus involved in sensory perception (GO:0050907)3.06263688
84histone exchange (GO:0043486)3.05234089
85mitotic cytokinesis (GO:0000281)3.04095093
86protoporphyrinogen IX biosynthetic process (GO:0006782)3.02215679
87mitotic spindle checkpoint (GO:0071174)3.02068595
88regulation of histone methylation (GO:0031060)3.01408965
89protoporphyrinogen IX metabolic process (GO:0046501)3.01140435
90histone phosphorylation (GO:0016572)2.98763568
91ribosome biogenesis (GO:0042254)2.98746198
92intra-S DNA damage checkpoint (GO:0031573)2.98511657
93spermatid nucleus differentiation (GO:0007289)2.97270393
94establishment of chromosome localization (GO:0051303)2.97048100
95N-terminal protein amino acid acetylation (GO:0006474)2.96718594
96positive regulation of histone methylation (GO:0031062)2.92813944
97spindle checkpoint (GO:0031577)2.91558755
98replicative senescence (GO:0090399)2.90752787
99sister chromatid cohesion (GO:0007062)2.90422096
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.88220473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.90471540
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.88520257
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.09551628
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.50547152
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48037918
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.27871815
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.17819954
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70004821
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63549245
10AR_21909140_ChIP-Seq_LNCAP_Human2.54666855
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35590021
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.34599379
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21350152
14GATA1_22025678_ChIP-Seq_K562_Human2.18481764
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.15361286
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11295399
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06931387
18ELK1_19687146_ChIP-ChIP_HELA_Human2.06720724
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.05620193
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03648148
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03321271
22E2F7_22180533_ChIP-Seq_HELA_Human11.1416863
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89944754
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.87573432
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.86330541
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86176485
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85983160
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85083085
29DCP1A_22483619_ChIP-Seq_HELA_Human1.84686677
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82045497
31CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.75374751
32VDR_23849224_ChIP-Seq_CD4+_Human1.72330534
33TTF2_22483619_ChIP-Seq_HELA_Human1.71220952
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66193013
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64526292
36XRN2_22483619_ChIP-Seq_HELA_Human1.62336135
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56667656
38KDM5A_27292631_Chip-Seq_BREAST_Human1.55630699
39NCOR1_26117541_ChIP-Seq_K562_Human1.50967294
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50928819
41FOXP3_21729870_ChIP-Seq_TREG_Human1.50499014
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46915917
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44188673
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41609009
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41421893
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36874199
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32697407
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29248505
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24109016
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23783939
51GABP_19822575_ChIP-Seq_HepG2_Human1.17350891
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13836831
53GATA1_19941826_ChIP-Seq_K562_Human1.10683445
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09399405
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09340403
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06152486
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02535917
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02094866
59FUS_26573619_Chip-Seq_HEK293_Human1.00359159
60KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97615168
61E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96958721
62* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95678529
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94991911
64ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92022422
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91853237
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89987233
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89514529
68ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88797957
69EWS_26573619_Chip-Seq_HEK293_Human0.87756433
70NOTCH1_21737748_ChIP-Seq_TLL_Human0.87523953
71CIITA_25753668_ChIP-Seq_RAJI_Human0.84313441
72GATA2_19941826_ChIP-Seq_K562_Human0.84060704
73VDR_22108803_ChIP-Seq_LS180_Human0.82075560
74NFYB_21822215_ChIP-Seq_K562_Human0.81329246
75PHF8_20622853_ChIP-Seq_HELA_Human0.80801150
76MYC_18940864_ChIP-ChIP_HL60_Human0.79519515
77CHD1_26751641_Chip-Seq_LNCaP_Human0.77783703
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77382937
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75485307
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74316330
81HNFA_21074721_ChIP-Seq_CACO-2_Human0.73883452
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73772412
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.73188416
84TFEB_21752829_ChIP-Seq_HELA_Human0.73168761
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72011220
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70581422
87RBPJ_21746931_ChIP-Seq_IB4_Human0.70506658
88ER_23166858_ChIP-Seq_MCF-7_Human0.67879268
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.67806966
90SRF_21415370_ChIP-Seq_HL-1_Mouse0.66982325
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66663345
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66364725
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.65762875
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65445087
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.63814216
96PKCTHETA_26484144_Chip-Seq_BREAST_Human0.63245265
97CBX2_22325352_ChIP-Seq_293T-Rex_Human0.63210489
98NFYA_21822215_ChIP-Seq_K562_Human0.63177585
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.62948143
100TAF15_26573619_Chip-Seq_HEK293_Human0.62920461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation5.07430223
2MP0008057_abnormal_DNA_replication4.63276570
3MP0010094_abnormal_chromosome_stability4.57787352
4MP0004957_abnormal_blastocyst_morpholog4.25727084
5MP0008058_abnormal_DNA_repair3.72930917
6MP0003111_abnormal_nucleus_morphology3.68929038
7MP0003693_abnormal_embryo_hatching3.67647017
8MP0003077_abnormal_cell_cycle3.30259149
9MP0005410_abnormal_fertilization3.15296815
10MP0003718_maternal_effect2.70833322
11MP0008932_abnormal_embryonic_tissue2.35897917
12MP0008995_early_reproductive_senescence2.35207391
13MP0008007_abnormal_cellular_replicative2.31524837
14MP0003786_premature_aging2.30087419
15MP0010234_abnormal_vibrissa_follicle2.24937912
16MP0001929_abnormal_gametogenesis2.19110319
17MP0002009_preneoplasia2.18947989
18MP0010307_abnormal_tumor_latency2.17034331
19MP0004185_abnormal_adipocyte_glucose2.11135738
20MP0000678_abnormal_parathyroid_gland2.09401007
21MP0004147_increased_porphyrin_level1.91587986
22MP0001730_embryonic_growth_arrest1.89537043
23MP0002877_abnormal_melanocyte_morpholog1.85604723
24MP0000350_abnormal_cell_proliferation1.83739652
25MP0003698_abnormal_male_reproductive1.71082848
26MP0002210_abnormal_sex_determination1.67915578
27MP0008961_abnormal_basal_metabolism1.65318378
28MP0001697_abnormal_embryo_size1.61275014
29MP0006035_abnormal_mitochondrial_morpho1.60853101
30MP0002396_abnormal_hematopoietic_system1.60126405
31MP0003950_abnormal_plasma_membrane1.53810078
32MP0010352_gastrointestinal_tract_polyps1.51143622
33MP0005380_embryogenesis_phenotype1.49260183
34MP0001672_abnormal_embryogenesis/_devel1.49260183
35MP0003221_abnormal_cardiomyocyte_apopto1.48339682
36MP0006292_abnormal_olfactory_placode1.44979321
37MP0000313_abnormal_cell_death1.42531472
38MP0001661_extended_life_span1.40546264
39MP0004233_abnormal_muscle_weight1.40011975
40MP0003656_abnormal_erythrocyte_physiolo1.35490909
41MP0002080_prenatal_lethality1.35364709
42MP0003984_embryonic_growth_retardation1.33595295
43MP0005451_abnormal_body_composition1.30743767
44MP0003890_abnormal_embryonic-extraembry1.29826662
45MP0002161_abnormal_fertility/fecundity1.27713829
46MP0002088_abnormal_embryonic_growth/wei1.26455583
47MP0002086_abnormal_extraembryonic_tissu1.26250946
48MP0000569_abnormal_digit_pigmentation1.20350740
49MP0004808_abnormal_hematopoietic_stem1.19971339
50MP0002084_abnormal_developmental_patter1.19484271
51MP0001145_abnormal_male_reproductive1.16420578
52MP0002085_abnormal_embryonic_tissue1.15205455
53MP0003699_abnormal_female_reproductive1.12667069
54MP0000653_abnormal_sex_gland1.11604775
55MP0001873_stomach_inflammation1.11350074
56MP0006036_abnormal_mitochondrial_physio1.07961266
57MP0001545_abnormal_hematopoietic_system1.06546975
58MP0005397_hematopoietic_system_phenotyp1.06546975
59MP0005076_abnormal_cell_differentiation1.06521043
60MP0000358_abnormal_cell_content/1.06142112
61MP0009115_abnormal_fat_cell1.04289578
62MP0002160_abnormal_reproductive_system1.01056290
63MP0008877_abnormal_DNA_methylation0.99743735
64MP0001727_abnormal_embryo_implantation0.98353598
65MP0002234_abnormal_pharynx_morphology0.96055609
66MP0001293_anophthalmia0.95716060
67MP0002970_abnormal_white_adipose0.93540303
68MP0002269_muscular_atrophy0.93312229
69MP0005666_abnormal_adipose_tissue0.92910586
70MP0004197_abnormal_fetal_growth/weight/0.90952391
71MP0001881_abnormal_mammary_gland0.89370156
72MP0002095_abnormal_skin_pigmentation0.89068418
73MP0003385_abnormal_body_wall0.86587761
74MP0002019_abnormal_tumor_incidence0.86184553
75MP0002971_abnormal_brown_adipose0.77385912
76MP0003937_abnormal_limbs/digits/tail_de0.75894219
77MP0004145_abnormal_muscle_electrophysio0.71116836
78MP0001286_abnormal_eye_development0.70360220
79MP0003936_abnormal_reproductive_system0.67435554
80MP0005187_abnormal_penis_morphology0.65682241
81MP0001348_abnormal_lacrimal_gland0.65511007
82MP0005266_abnormal_metabolism0.64716288
83MP0005083_abnormal_biliary_tract0.64667550
84MP0003959_abnormal_lean_body0.64320092
85MP0008770_decreased_survivor_rate0.64281843
86MP0005395_other_phenotype0.63724022
87MP0003935_abnormal_craniofacial_develop0.62574468
88MP0000015_abnormal_ear_pigmentation0.62114348
89MP0010678_abnormal_skin_adnexa0.62031111
90MP0001119_abnormal_female_reproductive0.60614607
91MP0003646_muscle_fatigue0.58946285
92MP0005408_hypopigmentation0.56972583
93MP0000703_abnormal_thymus_morphology0.56591103
94MP0000427_abnormal_hair_cycle0.55969556
95MP0001879_abnormal_lymphatic_vessel0.55720755
96MP0002249_abnormal_larynx_morphology0.54876806
97MP0008775_abnormal_heart_ventricle0.53241112
98MP0000647_abnormal_sebaceous_gland0.52100190
99MP0002092_abnormal_eye_morphology0.51176913
100MP0009703_decreased_birth_body0.51145780

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.68000406
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.30438436
3Progressive external ophthalmoplegia (HP:0000590)4.59073005
4Birth length less than 3rd percentile (HP:0003561)4.11441375
5Abnormality of chromosome stability (HP:0003220)3.94578027
6Acute myeloid leukemia (HP:0004808)3.94393058
7Sensory axonal neuropathy (HP:0003390)3.83521966
8Truncus arteriosus (HP:0001660)3.75774754
9Premature ovarian failure (HP:0008209)3.65781990
10Cholecystitis (HP:0001082)3.62757552
11Abnormal gallbladder physiology (HP:0012438)3.62757552
12Ankyloglossia (HP:0010296)3.59917641
13Fatigue (HP:0012378)3.53492566
14Aplasia/Hypoplasia of the earlobes (HP:0009906)3.39387676
15Abnormality of the preputium (HP:0100587)3.38710653
16Bowel incontinence (HP:0002607)3.28294380
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.25265476
18Cortical dysplasia (HP:0002539)3.18833360
19Abnormal large intestine physiology (HP:0012700)3.12333587
20Progressive muscle weakness (HP:0003323)3.09388894
21Duodenal stenosis (HP:0100867)3.05953277
22Small intestinal stenosis (HP:0012848)3.05953277
23Sandal gap (HP:0001852)3.01220904
24Myelodysplasia (HP:0002863)3.01218844
25Reticulocytosis (HP:0001923)2.87573469
26Male infertility (HP:0003251)2.74536067
27Upper limb muscle weakness (HP:0003484)2.73906137
28Abnormality of reticulocytes (HP:0004312)2.70513636
29Meckel diverticulum (HP:0002245)2.70352645
30Ragged-red muscle fibers (HP:0003200)2.69041262
31Abnormality of the carotid arteries (HP:0005344)2.68821878
32Increased nuchal translucency (HP:0010880)2.65217696
33Abnormality of the ileum (HP:0001549)2.64862638
34Hyperthyroidism (HP:0000836)2.56673497
35Impaired proprioception (HP:0010831)2.56362374
36Abnormality of the fingertips (HP:0001211)2.56206683
37Insomnia (HP:0100785)2.55875898
38Nephroblastoma (Wilms tumor) (HP:0002667)2.46895209
39Polycythemia (HP:0001901)2.46222867
40Hypoparathyroidism (HP:0000829)2.42735866
41Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.41862776
42Abnormality of oral frenula (HP:0000190)2.37593285
43Sloping forehead (HP:0000340)2.35712544
44Reticulocytopenia (HP:0001896)2.34498432
45Cafe-au-lait spot (HP:0000957)2.34366367
46Abnormality of cochlea (HP:0000375)2.34331182
47Hypergonadotropic hypogonadism (HP:0000815)2.33657698
48Duplicated collecting system (HP:0000081)2.33584148
49Abnormality of DNA repair (HP:0003254)2.33206935
50Rhabdomyosarcoma (HP:0002859)2.30210432
51Embryonal renal neoplasm (HP:0011794)2.28571539
52Abnormality of the duodenum (HP:0002246)2.25519414
53Papillary thyroid carcinoma (HP:0002895)2.25493903
54Poikilocytosis (HP:0004447)2.23345103
55Multiple enchondromatosis (HP:0005701)2.19791255
56Abnormality of glycolysis (HP:0004366)2.14475210
57Increased serum pyruvate (HP:0003542)2.12450142
58Progressive hearing impairment (HP:0001730)2.12142753
59Acanthocytosis (HP:0001927)2.09100482
60Volvulus (HP:0002580)2.09089909
61Obsessive-compulsive behavior (HP:0000722)2.08766131
62Homocystinuria (HP:0002156)2.01107262
63Abnormality of homocysteine metabolism (HP:0010919)2.01107262
64Abnormality of the pons (HP:0007361)1.97526948
65Aplasia/Hypoplasia of the thymus (HP:0010515)1.96279299
66Abnormality of the renal collecting system (HP:0004742)1.94176568
67Hypertensive crisis (HP:0100735)1.93543906
68Combined immunodeficiency (HP:0005387)1.91520169
69Clubbing of toes (HP:0100760)1.89996319
70Flat cornea (HP:0007720)1.88412797
71Impulsivity (HP:0100710)1.86361172
72Tubulointerstitial nephritis (HP:0001970)1.84244354
73Hypoplasia of the pons (HP:0012110)1.82964728
74Insidious onset (HP:0003587)1.82551178
75Termporal pattern (HP:0011008)1.82551178
76Missing ribs (HP:0000921)1.81434037
77Abnormality of the labia minora (HP:0012880)1.81271130
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80733037
79Abnormal lung lobation (HP:0002101)1.80413333
80Progressive inability to walk (HP:0002505)1.80335257
81Dysmetric saccades (HP:0000641)1.80237904
82Seborrheic dermatitis (HP:0001051)1.80025228
83Pallor (HP:0000980)1.79111011
84Absent thumb (HP:0009777)1.78418341
85Embryonal neoplasm (HP:0002898)1.73120870
86Cholelithiasis (HP:0001081)1.72134403
87Abnormality of the tricuspid valve (HP:0001702)1.72016706
88Dysphonia (HP:0001618)1.71835342
89Arteriovenous malformation (HP:0100026)1.70453866
90Choanal atresia (HP:0000453)1.68607240
91Pheochromocytoma (HP:0002666)1.68458162
92Abnormality of chromosome segregation (HP:0002916)1.68103918
93Abnormal hemoglobin (HP:0011902)1.66687002
94Underdeveloped nasal alae (HP:0000430)1.66583448
95Orthostatic hypotension (HP:0001278)1.66274670
96Spinal muscular atrophy (HP:0007269)1.65903154
97Cheekbone underdevelopment (HP:0010669)1.65309801
98Bone marrow hypocellularity (HP:0005528)1.65231532
99Long foot (HP:0001833)1.62851306
100Thyroid carcinoma (HP:0002890)1.62673583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.33279894
2PLK43.96307955
3TTK3.61144175
4EEF2K3.05755283
5CDC72.97986197
6DYRK32.85385463
7MST1R2.65886312
8EIF2AK32.50645134
9MAP3K22.50255436
10TSSK62.38990197
11KSR22.33489598
12EIF2AK12.28131750
13NEK12.16824266
14PBK2.14331755
15BRD42.03191125
16SRPK11.99124054
17WNK41.98125058
18TNIK1.88153890
19SCYL21.86235951
20RIPK41.84601316
21RAF11.78354375
22BMPR21.77517178
23ZAK1.77175788
24NEK21.69351401
25WEE11.66479597
26BUB11.66206585
27BRSK21.58859611
28CCNB11.56308271
29CHEK21.52402262
30CDK121.50591779
31STK391.49937414
32STK101.44457404
33NTRK31.41823044
34MAP3K81.36269531
35TRPM71.35668123
36PLK11.34078052
37RPS6KB21.27669298
38WNK11.27555702
39CHEK11.23982306
40ATR1.19870034
41KSR11.17006480
42CLK11.16245963
43PLK31.11846425
44MAP3K41.10283365
45MET1.02396583
46NEK60.98054818
47BRAF0.96471383
48AURKB0.90327291
49ATM0.89315462
50STK30.87326749
51NME10.80907622
52RPS6KA40.78252755
53FGFR10.77338326
54AKT20.72078584
55CDK10.70612797
56MAPKAPK30.70402241
57BRSK10.70246512
58CDK20.67856158
59PIK3CG0.66884800
60CDK70.66098038
61ALK0.64760312
62LATS10.61185207
63STK160.60767958
64PLK20.59869532
65ICK0.59227540
66AKT30.59046063
67EIF2AK20.57812487
68ERBB30.56766427
69LATS20.50940727
70RPS6KB10.50092239
71CSNK2A20.49130046
72MAPKAPK50.48592571
73MKNK20.48096593
74AURKA0.47567829
75CSNK1E0.44923309
76MKNK10.43712000
77CAMK1D0.42131525
78BMX0.39375777
79MTOR0.38870683
80MAP3K140.38604348
81MAP3K60.38469294
82CDK80.38442009
83CAMK1G0.36650498
84MAPK140.35784867
85PRKACB0.34634544
86MAP2K10.34305549
87GSK3B0.30495170
88CDK40.29331037
89PNCK0.28490875
90PRKDC0.25938251
91TEC0.25779947
92RET0.25411424
93PRKCI0.24022944
94CSNK2A10.23455022
95ERBB40.22668157
96PRKAA10.21961119
97SGK10.21859102
98BMPR1B0.21663842
99MAPK100.21599185
100STK40.21140473

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.56276557
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.31663338
3Non-homologous end-joining_Homo sapiens_hsa034503.69407016
4Mismatch repair_Homo sapiens_hsa034303.49904073
5* Olfactory transduction_Homo sapiens_hsa047403.40062363
6DNA replication_Homo sapiens_hsa030303.33522615
7One carbon pool by folate_Homo sapiens_hsa006703.27460095
8Homologous recombination_Homo sapiens_hsa034403.19436974
9Basal transcription factors_Homo sapiens_hsa030223.16179349
10RNA transport_Homo sapiens_hsa030133.05941706
11Cell cycle_Homo sapiens_hsa041102.79844502
12Fanconi anemia pathway_Homo sapiens_hsa034602.73269358
13Nucleotide excision repair_Homo sapiens_hsa034202.18976976
14Spliceosome_Homo sapiens_hsa030402.12186763
15mRNA surveillance pathway_Homo sapiens_hsa030152.05513889
16RNA degradation_Homo sapiens_hsa030182.02618443
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85102858
18RNA polymerase_Homo sapiens_hsa030201.77699109
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.63202838
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.43902646
21Selenocompound metabolism_Homo sapiens_hsa004501.37690317
22Oocyte meiosis_Homo sapiens_hsa041141.34718187
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30164569
24Thyroid cancer_Homo sapiens_hsa052161.29703832
25Fatty acid biosynthesis_Homo sapiens_hsa000611.26589645
26Base excision repair_Homo sapiens_hsa034101.21852796
27Pyrimidine metabolism_Homo sapiens_hsa002401.15882098
28Ribosome_Homo sapiens_hsa030101.10297905
29Purine metabolism_Homo sapiens_hsa002301.01214613
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00634255
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99230786
32Adherens junction_Homo sapiens_hsa045200.98341859
33Pyruvate metabolism_Homo sapiens_hsa006200.98119655
34Vitamin B6 metabolism_Homo sapiens_hsa007500.93175123
35Viral carcinogenesis_Homo sapiens_hsa052030.92967057
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92147479
37ErbB signaling pathway_Homo sapiens_hsa040120.91150155
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85230504
39Chronic myeloid leukemia_Homo sapiens_hsa052200.83985375
40Acute myeloid leukemia_Homo sapiens_hsa052210.78674039
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78501938
42Alcoholism_Homo sapiens_hsa050340.77399834
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76136152
44Dorso-ventral axis formation_Homo sapiens_hsa043200.75601573
45Epstein-Barr virus infection_Homo sapiens_hsa051690.72006763
46Biosynthesis of amino acids_Homo sapiens_hsa012300.70993355
47p53 signaling pathway_Homo sapiens_hsa041150.66545737
48Systemic lupus erythematosus_Homo sapiens_hsa053220.65756108
49Type II diabetes mellitus_Homo sapiens_hsa049300.64760751
50Pancreatic cancer_Homo sapiens_hsa052120.61754422
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57391920
52Butanoate metabolism_Homo sapiens_hsa006500.57259611
53MicroRNAs in cancer_Homo sapiens_hsa052060.55994362
54Carbon metabolism_Homo sapiens_hsa012000.55474063
55Arginine biosynthesis_Homo sapiens_hsa002200.55449318
56Propanoate metabolism_Homo sapiens_hsa006400.54477796
57Herpes simplex infection_Homo sapiens_hsa051680.51932318
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48525677
59mTOR signaling pathway_Homo sapiens_hsa041500.47851286
60Tight junction_Homo sapiens_hsa045300.44854089
61Lysine degradation_Homo sapiens_hsa003100.44133178
62Non-small cell lung cancer_Homo sapiens_hsa052230.43149600
63Proteasome_Homo sapiens_hsa030500.42572900
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37707522
65Arginine and proline metabolism_Homo sapiens_hsa003300.36840411
66Prostate cancer_Homo sapiens_hsa052150.36640150
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35690817
68Renal cell carcinoma_Homo sapiens_hsa052110.34596510
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33165611
70Glutathione metabolism_Homo sapiens_hsa004800.32689866
71Colorectal cancer_Homo sapiens_hsa052100.31206060
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30910436
73Glioma_Homo sapiens_hsa052140.28061693
74Inositol phosphate metabolism_Homo sapiens_hsa005620.27606415
75Measles_Homo sapiens_hsa051620.27404098
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26712243
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26630344
78Huntingtons disease_Homo sapiens_hsa050160.26615619
79VEGF signaling pathway_Homo sapiens_hsa043700.26586517
80HTLV-I infection_Homo sapiens_hsa051660.26505915
81Wnt signaling pathway_Homo sapiens_hsa043100.26443301
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26233565
83Prolactin signaling pathway_Homo sapiens_hsa049170.25042362
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24899625
85B cell receptor signaling pathway_Homo sapiens_hsa046620.24713670
86Insulin signaling pathway_Homo sapiens_hsa049100.24262895
87Estrogen signaling pathway_Homo sapiens_hsa049150.24018264
88TGF-beta signaling pathway_Homo sapiens_hsa043500.22504095
89Steroid biosynthesis_Homo sapiens_hsa001000.20362940
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.18424805
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17878740
92Hepatitis B_Homo sapiens_hsa051610.17200312
93Fatty acid metabolism_Homo sapiens_hsa012120.15805302
94Long-term potentiation_Homo sapiens_hsa047200.14428326
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12997968
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12393213
97HIF-1 signaling pathway_Homo sapiens_hsa040660.12148223
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.11804082
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.11253712
100Metabolic pathways_Homo sapiens_hsa011000.10533824

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