ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	paraxial mesoderm development (GO:0048339)	7.11139881
2	glycosylceramide metabolic process (GO:0006677)	5.51849762
3	muscle organ morphogenesis (GO:0048644)	4.79985350
4	ear development (GO:0043583)	4.78150021
5	positive regulation of male gonad development (GO:2000020)	4.72179232
6	somite development (GO:0061053)	4.70873091
7	polarized epithelial cell differentiation (GO:0030859)	4.67684691
8	behavioral response to nicotine (GO:0035095)	4.64523488
9	sialylation (GO:0097503)	4.64237509
10	epithelial cilium movement (GO:0003351)	4.59339568
11	regulation of mesoderm development (GO:2000380)	4.58263081
12	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	4.47412664
13	positive regulation of gastrulation (GO:2000543)	4.45730927
14	retinal ganglion cell axon guidance (GO:0031290)	4.42387177
15	neuromuscular process controlling posture (GO:0050884)	4.29138839
16	neural tube formation (GO:0001841)	4.15174419
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.05173949
18	postsynaptic membrane organization (GO:0001941)	3.96821111
19	negative regulation of leukocyte chemotaxis (GO:0002689)	3.92950491
20	nonmotile primary cilium assembly (GO:0035058)	3.79129324
21	post-anal tail morphogenesis (GO:0036342)	3.78389702
22	inner ear receptor stereocilium organization (GO:0060122)	3.74698855
23	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.71444210
24	cellular ketone body metabolic process (GO:0046950)	3.69640175
25	regulation of male gonad development (GO:2000018)	3.68381302
26	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.66192396
27	response to nitrosative stress (GO:0051409)	3.61234738
28	axoneme assembly (GO:0035082)	3.58645040
29	establishment of apical/basal cell polarity (GO:0035089)	3.52720775
30	DNA double-strand break processing (GO:0000729)	3.46018459
31	sequestering of actin monomers (GO:0042989)	3.41865528
32	establishment of monopolar cell polarity (GO:0061162)	3.41466728
33	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.41466728
34	cilium movement (GO:0003341)	3.38877313
35	positive regulation of protein sumoylation (GO:0033235)	3.35069928
36	resolution of meiotic recombination intermediates (GO:0000712)	3.34682728
37	cilium morphogenesis (GO:0060271)	3.34268377
38	presynaptic membrane assembly (GO:0097105)	3.32301798
39	ketone body metabolic process (GO:1902224)	3.26389512
40	platelet dense granule organization (GO:0060155)	3.24117015
41	regulation of glucokinase activity (GO:0033131)	3.18468515
42	regulation of hexokinase activity (GO:1903299)	3.18468515
43	dorsal/ventral neural tube patterning (GO:0021904)	3.17771981
44	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.12400382
45	regulation of translation, ncRNA-mediated (GO:0045974)	3.12400382
46	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.12400382
47	water-soluble vitamin biosynthetic process (GO:0042364)	3.11482448
48	establishment of epithelial cell polarity (GO:0090162)	3.11114115
49	regulation of gastrulation (GO:0010470)	3.10347333
50	mesenchymal to epithelial transition (GO:0060231)	3.09639274
51	establishment of tissue polarity (GO:0007164)	3.06893105
52	establishment of planar polarity (GO:0001736)	3.06893105
53	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.02197189
54	axon extension involved in axon guidance (GO:0048846)	3.02197189
55	positive regulation of mitochondrial fission (GO:0090141)	3.01897785
56	determination of left/right symmetry (GO:0007368)	2.96027791
57	protein polyglutamylation (GO:0018095)	2.95409051
58	respiratory system process (GO:0003016)	2.94278808
59	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	2.94209345
60	negative chemotaxis (GO:0050919)	2.93371268
61	negative regulation of heart rate (GO:0010459)	2.88042218
62	organ induction (GO:0001759)	2.86621925
63	negative regulation of vascular permeability (GO:0043116)	2.85772950
64	limb bud formation (GO:0060174)	2.85158188
65	determination of bilateral symmetry (GO:0009855)	2.84621158
66	smoothened signaling pathway (GO:0007224)	2.84140012
67	negative regulation of axon guidance (GO:1902668)	2.83878158
68	cilium assembly (GO:0042384)	2.82116410
69	male sex determination (GO:0030238)	2.82053949
70	cilium or flagellum-dependent cell motility (GO:0001539)	2.82023154
71	cilium organization (GO:0044782)	2.81791641
72	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.81573727
73	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.81573727
74	prenylation (GO:0097354)	2.80937312
75	protein prenylation (GO:0018342)	2.80937312
76	regulation of telomere maintenance (GO:0032204)	2.80549097
77	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.78597268
78	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.77970783
79	response to redox state (GO:0051775)	2.77321521
80	presynaptic membrane organization (GO:0097090)	2.77101960
81	DNA integration (GO:0015074)	2.76746464
82	regulation of cell fate specification (GO:0042659)	2.74802853
83	specification of symmetry (GO:0009799)	2.74372490
84	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.72997433
85	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.72997433
86	neuron cell-cell adhesion (GO:0007158)	2.72920581
87	branch elongation of an epithelium (GO:0060602)	2.72608119
88	regulation of cilium movement (GO:0003352)	2.70183807
89	organelle disassembly (GO:1903008)	2.68354107
90	somite rostral/caudal axis specification (GO:0032525)	2.68243364
91	sulfation (GO:0051923)	2.67650958
92	positive regulation of cell cycle G2/M phase transition (GO:1902751)	2.67325683
93	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	2.67325683
94	replication fork processing (GO:0031297)	2.67307946
95	regulation of collateral sprouting (GO:0048670)	2.66794129
96	apical protein localization (GO:0045176)	2.65418760
97	pituitary gland development (GO:0021983)	2.65304383
98	dorsal/ventral axis specification (GO:0009950)	2.64847996
99	dorsal/ventral pattern formation (GO:0009953)	2.63739533
100	protein autoubiquitination (GO:0051865)	2.61304979

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00233801
2	EWS_26573619_Chip-Seq_HEK293_Human	2.90172608
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.85810636
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.76396593
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.69903683
6	VDR_22108803_ChIP-Seq_LS180_Human	2.68509541
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.55578083
8	FUS_26573619_Chip-Seq_HEK293_Human	2.49622056
9	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.47404882
10	P300_19829295_ChIP-Seq_ESCs_Human	2.30403291
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.28254498
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26810957
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.22565205
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21855723
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18043107
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.11289926
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09473381
18	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.01214356
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.00772314
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.93093035
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91957866
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.88236939
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86035188
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85761228
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.83141412
26	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.81768702
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.80949308
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.78457184
29	STAT3_23295773_ChIP-Seq_U87_Human	1.77321643
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77156427
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70036321
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69042491
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.63838542
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.61607543
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60915785
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.60048760
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58747409
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.58048077
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.58048077
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57161727
41	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52859305
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51679117
43	RUNX2_22187159_ChIP-Seq_PCA_Human	1.51648661
44	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.50992988
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50535845
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49744071
47	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.49563112
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49065342
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49061893
50	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49009132
51	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.46262983
52	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.43936675
53	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.43936675
54	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.43936675
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43685309
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41955705
57	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.41671564
58	AR_25329375_ChIP-Seq_VCAP_Human	1.41420069
59	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.39972714
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.39701596
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39701596
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39118940
63	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.37921158
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36260278
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33198820
66	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.31867908
67	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.31187724
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28722640
69	TCF4_23295773_ChIP-Seq_U87_Human	1.27601767
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.27155007
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26952811
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26490002
73	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.26352109
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25426701
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25189595
76	TP53_18474530_ChIP-ChIP_U2OS_Human	1.22913862
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20600162
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20022874
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19473448
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18675953
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17940010
82	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.17880450
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.17285482
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16747335
85	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16747335
86	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.16671113
87	BCAT_22108803_ChIP-Seq_LS180_Human	1.14293892
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.12871029
89	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.07609003
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07142985
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06965003
92	TP53_16413492_ChIP-PET_HCT116_Human	1.04766978
93	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04753007
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04403439
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02035044
96	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01983707
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01171228
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.99319424
99	VDR_23849224_ChIP-Seq_CD4+_Human	0.99202118
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99061170

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003941_abnormal_skin_development	5.64293046
2	MP0003011_delayed_dark_adaptation	3.96846250
3	MP0004133_heterotaxia	3.80056799
4	MP0006072_abnormal_retinal_apoptosis	3.67908329
5	MP0003880_abnormal_central_pattern	3.60625001
6	MP0006292_abnormal_olfactory_placode	3.08805237
7	MP0005248_abnormal_Harderian_gland	2.99138223
8	MP0000383_abnormal_hair_follicle	2.81065416
9	MP0000647_abnormal_sebaceous_gland	2.40712582
10	MP0003890_abnormal_embryonic-extraembry	2.23029655
11	MP0000778_abnormal_nervous_system	2.09252009
12	MP0001529_abnormal_vocalization	2.08554951
13	MP0002009_preneoplasia	2.03678592
14	MP0005551_abnormal_eye_electrophysiolog	2.01567453
15	MP0006054_spinal_hemorrhage	2.01255405
16	MP0005171_absent_coat_pigmentation	1.99870200
17	MP0003937_abnormal_limbs/digits/tail_de	1.93539149
18	MP0000566_synostosis	1.92317823
19	MP0001293_anophthalmia	1.86869457
20	MP0005253_abnormal_eye_physiology	1.83055240
21	MP0006276_abnormal_autonomic_nervous	1.80565673
22	MP0003136_yellow_coat_color	1.79531371
23	MP0000427_abnormal_hair_cycle	1.75953248
24	MP0010678_abnormal_skin_adnexa	1.69062133
25	MP0001486_abnormal_startle_reflex	1.62029010
26	MP0001299_abnormal_eye_distance/	1.61123541
27	MP0002653_abnormal_ependyma_morphology	1.58491227
28	MP0001984_abnormal_olfaction	1.54508632
29	MP0003878_abnormal_ear_physiology	1.51900011
30	MP0005377_hearing/vestibular/ear_phenot	1.51900011
31	MP0008961_abnormal_basal_metabolism	1.50253172
32	MP0003567_abnormal_fetal_cardiomyocyte	1.48735719
33	MP0002277_abnormal_respiratory_mucosa	1.42114236
34	MP0001485_abnormal_pinna_reflex	1.41451652
35	MP0000631_abnormal_neuroendocrine_gland	1.40645133
36	MP0002928_abnormal_bile_duct	1.34068313
37	MP0002938_white_spotting	1.31106552
38	MP0000569_abnormal_digit_pigmentation	1.30961088
39	MP0002233_abnormal_nose_morphology	1.29683874
40	MP0005187_abnormal_penis_morphology	1.29536723
41	MP0008877_abnormal_DNA_methylation	1.29246595
42	MP0001346_abnormal_lacrimal_gland	1.28428137
43	MP0001963_abnormal_hearing_physiology	1.23178683
44	MP0003122_maternal_imprinting	1.21848426
45	MP0010030_abnormal_orbit_morphology	1.21500102
46	MP0000026_abnormal_inner_ear	1.21083352
47	MP0004742_abnormal_vestibular_system	1.17360134
48	MP0005423_abnormal_somatic_nervous	1.15555881
49	MP0002111_abnormal_tail_morphology	1.15148608
50	MP0002090_abnormal_vision	1.13679279
51	MP0005646_abnormal_pituitary_gland	1.12398345
52	MP0000579_abnormal_nail_morphology	1.10439546
53	MP0003938_abnormal_ear_development	1.09608601
54	MP0005391_vision/eye_phenotype	1.09370391
55	MP0003385_abnormal_body_wall	1.08825551
56	MP0001286_abnormal_eye_development	1.07362162
57	MP0004145_abnormal_muscle_electrophysio	1.07023348
58	MP0002116_abnormal_craniofacial_bone	1.01885235
59	MP0003646_muscle_fatigue	0.99744445
60	MP0003119_abnormal_digestive_system	0.99743453
61	MP0002177_abnormal_outer_ear	0.99624985
62	MP0003942_abnormal_urinary_system	0.98972317
63	MP0003787_abnormal_imprinting	0.98189946
64	MP0001502_abnormal_circadian_rhythm	0.92309495
65	MP0008875_abnormal_xenobiotic_pharmacok	0.89776177
66	MP0003195_calcinosis	0.84930270
67	MP0003755_abnormal_palate_morphology	0.84883501
68	MP0004885_abnormal_endolymph	0.84443683
69	MP0000534_abnormal_ureter_morphology	0.84329493
70	MP0009384_cardiac_valve_regurgitation	0.83338784
71	MP0002234_abnormal_pharynx_morphology	0.83040890
72	MP0008932_abnormal_embryonic_tissue	0.81976429
73	MP0003121_genomic_imprinting	0.81954004
74	MP0002752_abnormal_somatic_nervous	0.81678453
75	MP0000372_irregular_coat_pigmentation	0.81358611
76	MP0002109_abnormal_limb_morphology	0.79929113
77	MP0003698_abnormal_male_reproductive	0.79417089
78	MP0003861_abnormal_nervous_system	0.79344215
79	MP0002184_abnormal_innervation	0.79225455
80	MP0002638_abnormal_pupillary_reflex	0.78853450
81	MP0010386_abnormal_urinary_bladder	0.77633111
82	MP0002697_abnormal_eye_size	0.75501835
83	MP0000432_abnormal_head_morphology	0.75105801
84	MP0006035_abnormal_mitochondrial_morpho	0.75030461
85	MP0008789_abnormal_olfactory_epithelium	0.74986714
86	MP0002084_abnormal_developmental_patter	0.74984082
87	MP0002272_abnormal_nervous_system	0.74918210
88	MP0000049_abnormal_middle_ear	0.74706979
89	MP0002152_abnormal_brain_morphology	0.72992236
90	MP0009745_abnormal_behavioral_response	0.71972717
91	MP0000955_abnormal_spinal_cord	0.71643075
92	MP0004142_abnormal_muscle_tone	0.71433540
93	MP0002127_abnormal_cardiovascular_syste	0.71056931
94	MP0002751_abnormal_autonomic_nervous	0.70304920
95	MP0003137_abnormal_impulse_conducting	0.68697471
96	MP0002736_abnormal_nociception_after	0.67213547
97	MP0002932_abnormal_joint_morphology	0.66073458
98	MP0009697_abnormal_copulation	0.65956964
99	MP0005410_abnormal_fertilization	0.63967221
100	MP0000751_myopathy	0.63926315

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	5.79996990
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.19627945
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.19627945
4	Abnormality of midbrain morphology (HP:0002418)	4.17828830
5	Molar tooth sign on MRI (HP:0002419)	4.17828830
6	Colon cancer (HP:0003003)	3.87623915
7	Pancreatic fibrosis (HP:0100732)	3.83390470
8	Pancreatic cysts (HP:0001737)	3.63791300
9	Volvulus (HP:0002580)	3.43151929
10	Abnormality of the corticospinal tract (HP:0002492)	3.35118287
11	Bifid tongue (HP:0010297)	3.27171746
12	Supernumerary spleens (HP:0009799)	3.25183215
13	Gaze-evoked nystagmus (HP:0000640)	3.23494877
14	Abnormal biliary tract physiology (HP:0012439)	3.20229327
15	Bile duct proliferation (HP:0001408)	3.20229327
16	Progressive cerebellar ataxia (HP:0002073)	3.07210287
17	Nephronophthisis (HP:0000090)	2.99984147
18	Chronic hepatic failure (HP:0100626)	2.92538477
19	Cystic liver disease (HP:0006706)	2.91542978
20	Hypoplastic ischia (HP:0003175)	2.89516541
21	Abnormality of abdominal situs (HP:0011620)	2.87321291
22	Abdominal situs inversus (HP:0003363)	2.87321291
23	Gonadal dysgenesis (HP:0000133)	2.84350408
24	Sex reversal (HP:0012245)	2.83808049
25	Abnormal sex determination (HP:0012244)	2.83808049
26	Fibular hypoplasia (HP:0003038)	2.75757149
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.75529012
28	Abnormality of the renal medulla (HP:0100957)	2.75488902
29	Abnormality of the labia minora (HP:0012880)	2.75371680
30	3-Methylglutaconic aciduria (HP:0003535)	2.73969317
31	Hyperglycinemia (HP:0002154)	2.64440779
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.58033205
33	Abnormality of the ischium (HP:0003174)	2.57005021
34	Methylmalonic acidemia (HP:0002912)	2.53853208
35	Abnormality of the pubic bones (HP:0003172)	2.44239150
36	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.43411082
37	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.38202022
38	Amyotrophic lateral sclerosis (HP:0007354)	2.37566225
39	Short tibia (HP:0005736)	2.33951466
40	Postaxial foot polydactyly (HP:0001830)	2.32551257
41	Genetic anticipation (HP:0003743)	2.32548027
42	Broad alveolar ridges (HP:0000187)	2.31701083
43	Occipital encephalocele (HP:0002085)	2.30980542
44	Anencephaly (HP:0002323)	2.30539409
45	Breast aplasia (HP:0100783)	2.26520771
46	Impaired vibration sensation in the lower limbs (HP:0002166)	2.24842716
47	Hypoplastic labia majora (HP:0000059)	2.24423223
48	Primary amenorrhea (HP:0000786)	2.21402145
49	Narrow forehead (HP:0000341)	2.21209753
50	Absent frontal sinuses (HP:0002688)	2.19906411
51	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.18986293
52	Methylmalonic aciduria (HP:0012120)	2.18976023
53	Male pseudohermaphroditism (HP:0000037)	2.16550127
54	Asplenia (HP:0001746)	2.14120176
55	Congenital hepatic fibrosis (HP:0002612)	2.13112857
56	Sclerocornea (HP:0000647)	2.11602696
57	Labial hypoplasia (HP:0000066)	2.11430275
58	Arthropathy (HP:0003040)	2.09405882
59	Exercise-induced muscle cramps (HP:0003710)	2.09095865
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.09036032
61	Postaxial hand polydactyly (HP:0001162)	2.05633127
62	Septo-optic dysplasia (HP:0100842)	2.03508852
63	Bilateral microphthalmos (HP:0007633)	2.01666106
64	Abnormality of the labia majora (HP:0012881)	1.99951360
65	Acute necrotizing encephalopathy (HP:0006965)	1.99122174
66	Acute encephalopathy (HP:0006846)	1.96946477
67	Diastasis recti (HP:0001540)	1.95115504
68	Urinary urgency (HP:0000012)	1.94796240
69	Abnormality of the renal cortex (HP:0011035)	1.94180320
70	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.93719817
71	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93247380
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.93247380
73	Hepatoblastoma (HP:0002884)	1.92258955
74	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.91440957
75	Abnormal ciliary motility (HP:0012262)	1.91237183
76	Vaginal atresia (HP:0000148)	1.90865873
77	Genital tract atresia (HP:0001827)	1.90541804
78	Urinary bladder sphincter dysfunction (HP:0002839)	1.88806867
79	Focal motor seizures (HP:0011153)	1.88448552
80	Hyperglycinuria (HP:0003108)	1.86598296
81	Medial flaring of the eyebrow (HP:0010747)	1.86283862
82	Preaxial hand polydactyly (HP:0001177)	1.86148223
83	Optic nerve coloboma (HP:0000588)	1.85698890
84	Oligodactyly (hands) (HP:0001180)	1.85237559
85	Abolished electroretinogram (ERG) (HP:0000550)	1.85230121
86	Proximal placement of thumb (HP:0009623)	1.80960125
87	Polyphagia (HP:0002591)	1.80387767
88	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.80353245
89	Impulsivity (HP:0100710)	1.80155413
90	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.78173517
91	Hypoplastic female external genitalia (HP:0012815)	1.77802582
92	Congenital primary aphakia (HP:0007707)	1.76985163
93	Aplasia/hypoplasia of the humerus (HP:0006507)	1.76301098
94	Oculomotor apraxia (HP:0000657)	1.75847384
95	Anophthalmia (HP:0000528)	1.75238368
96	High anterior hairline (HP:0009890)	1.74773870
97	Scrotal hypoplasia (HP:0000046)	1.74404923
98	Furrowed tongue (HP:0000221)	1.73708565
99	Vitreoretinal degeneration (HP:0000655)	1.72444599
100	Hematochezia (HP:0002573)	1.72229135

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.91692749
2	TRIM28	3.04835296
3	EPHA4	3.01367825
4	DYRK3	2.81056985
5	CDK19	2.72752077
6	BMPR1B	2.72675760
7	ADRBK2	2.66314628
8	TNK2	2.46543537
9	PINK1	2.26407968
10	ACVR1B	2.10117965
11	MAPK15	2.02118416
12	STK16	1.94737815
13	CDC7	1.84589669
14	PAK3	1.82899663
15	FRK	1.74436166
16	SRPK1	1.71219453
17	TNIK	1.68245496
18	VRK1	1.68224624
19	VRK2	1.61350574
20	MAP4K2	1.57932328
21	BRSK2	1.50000648
22	FGFR1	1.48242746
23	MKNK1	1.43168216
24	MAP3K4	1.36309980
25	PKN1	1.34971262
26	RPS6KA4	1.34575046
27	TGFBR1	1.34024559
28	ERBB3	1.33908445
29	PLK2	1.33523433
30	DYRK2	1.28613540
31	MAP2K7	1.23826664
32	BCR	1.21356197
33	TAF1	1.16436001
34	PNCK	1.16126222
35	PLK3	1.16043582
36	PLK4	1.15521329
37	MAP3K7	1.14340919
38	PTK2B	1.11381409
39	SGK2	1.09298743
40	ADRBK1	1.09250315
41	DYRK1B	1.07895640
42	PRKCE	1.00508449
43	FLT3	0.99439611
44	OBSCN	0.96466098
45	FGR	0.95399752
46	STK38L	0.93721016
47	MARK1	0.89040227
48	BUB1	0.87711572
49	EIF2AK3	0.85558658
50	BCKDK	0.85459174
51	DDR2	0.85278434
52	GRK1	0.84725345
53	CSNK1G2	0.82555145
54	DYRK1A	0.81149271
55	CHUK	0.79744793
56	EPHB2	0.74611923
57	PRKG1	0.74543495
58	INSRR	0.70780784
59	NUAK1	0.70021057
60	SGK494	0.68520667
61	SGK223	0.68520667
62	BRD4	0.68401809
63	CAMK2A	0.68123817
64	WNK1	0.67751609
65	CAMK1	0.67031968
66	TESK1	0.64899335
67	AKT3	0.63342253
68	SGK3	0.61961684
69	PKN2	0.61669506
70	PASK	0.61034416
71	YES1	0.60373825
72	PIM2	0.60221735
73	CSNK1A1L	0.59596974
74	ERBB2	0.56924825
75	PRKCZ	0.56213339
76	CSNK1G1	0.55754397
77	CSNK1G3	0.53912363
78	CAMK4	0.53304458
79	PRKCG	0.51897086
80	MAPK13	0.50336251
81	EGFR	0.49701468
82	CHEK2	0.45685245
83	BRSK1	0.45233648
84	PRKACA	0.43756730
85	PRKCQ	0.41435743
86	CSNK1A1	0.41104755
87	NTRK2	0.39673275
88	MAPK7	0.38607598
89	KSR1	0.37247293
90	ROCK2	0.35966651
91	PBK	0.35777864
92	PAK6	0.35394082
93	PLK1	0.34167435
94	MATK	0.33585659
95	OXSR1	0.30659102
96	KIT	0.28582543
97	TIE1	0.27546773
98	CAMKK2	0.27318536
99	PRKCB	0.27274040
100	ATR	0.26875343

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	6.48475486
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.77732076
3	Protein export_Homo sapiens_hsa03060	3.67600680
4	Propanoate metabolism_Homo sapiens_hsa00640	2.64299563
5	Butanoate metabolism_Homo sapiens_hsa00650	2.52055169
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.32703003
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.32512410
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.05918899
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03013275
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.96497188
11	Circadian rhythm_Homo sapiens_hsa04710	1.93234060
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79061267
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.73099247
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69113853
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66962108
16	Huntingtons disease_Homo sapiens_hsa05016	1.56404198
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52915999
18	Basal cell carcinoma_Homo sapiens_hsa05217	1.48454947
19	Parkinsons disease_Homo sapiens_hsa05012	1.38360739
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.31191594
21	Basal transcription factors_Homo sapiens_hsa03022	1.27285705
22	RNA polymerase_Homo sapiens_hsa03020	1.26461273
23	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.24272208
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.24237098
25	Ribosome_Homo sapiens_hsa03010	1.22940507
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22592150
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18015981
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17189284
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16502344
30	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.11766606
31	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.11615620
32	Phototransduction_Homo sapiens_hsa04744	1.10056467
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06245949
34	Glycerolipid metabolism_Homo sapiens_hsa00561	1.06041402
35	Homologous recombination_Homo sapiens_hsa03440	1.05094087
36	Ether lipid metabolism_Homo sapiens_hsa00565	0.99398896
37	Taste transduction_Homo sapiens_hsa04742	0.97205609
38	Regulation of autophagy_Homo sapiens_hsa04140	0.96779933
39	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96732543
40	Peroxisome_Homo sapiens_hsa04146	0.95098288
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93741440
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.93080368
43	Mismatch repair_Homo sapiens_hsa03430	0.92094693
44	One carbon pool by folate_Homo sapiens_hsa00670	0.90710187
45	Nicotine addiction_Homo sapiens_hsa05033	0.90419957
46	Glutathione metabolism_Homo sapiens_hsa00480	0.85363553
47	Alzheimers disease_Homo sapiens_hsa05010	0.83780707
48	Fatty acid degradation_Homo sapiens_hsa00071	0.83226234
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82444856
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.80323420
51	Retinol metabolism_Homo sapiens_hsa00830	0.79335533
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78930131
53	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.74667226
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72548933
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.71855350
56	GABAergic synapse_Homo sapiens_hsa04727	0.70898157
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.70305044
58	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.69587307
59	RNA degradation_Homo sapiens_hsa03018	0.69493976
60	Olfactory transduction_Homo sapiens_hsa04740	0.69064221
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68889112
62	Wnt signaling pathway_Homo sapiens_hsa04310	0.66218553
63	ABC transporters_Homo sapiens_hsa02010	0.65042630
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63555002
65	Cocaine addiction_Homo sapiens_hsa05030	0.63551786
66	Axon guidance_Homo sapiens_hsa04360	0.63217504
67	Morphine addiction_Homo sapiens_hsa05032	0.62139021
68	Metabolic pathways_Homo sapiens_hsa01100	0.60893592
69	RNA transport_Homo sapiens_hsa03013	0.59207448
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58795124
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.53402044
72	Circadian entrainment_Homo sapiens_hsa04713	0.52260352
73	Serotonergic synapse_Homo sapiens_hsa04726	0.51861894
74	Alcoholism_Homo sapiens_hsa05034	0.47309822
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46719834
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.45557827
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.43106283
78	Lysine degradation_Homo sapiens_hsa00310	0.42231720
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41710358
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.41353746
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41188473
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41110190
83	Melanogenesis_Homo sapiens_hsa04916	0.39610941
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.38528387
85	Folate biosynthesis_Homo sapiens_hsa00790	0.38494187
86	Cell cycle_Homo sapiens_hsa04110	0.37967051
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.37769950
88	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.37571258
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35560074
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35379018
91	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.31355039
92	Spliceosome_Homo sapiens_hsa03040	0.30280069
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.29866415
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.28354276
95	Sulfur relay system_Homo sapiens_hsa04122	0.27884659
96	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.26784927
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.25533304
98	Pathways in cancer_Homo sapiens_hsa05200	0.25314110
99	Purine metabolism_Homo sapiens_hsa00230	0.24742839
100	Caffeine metabolism_Homo sapiens_hsa00232	0.24244922

OR52T1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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