OR5E1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.92421670
2sperm capacitation (GO:0048240)7.99514869
3chromosome condensation (GO:0030261)7.98979467
4spermatid development (GO:0007286)7.75230396
5DNA packaging (GO:0006323)7.66611700
6plasma membrane fusion (GO:0045026)7.51439677
7response to pheromone (GO:0019236)7.47474828
8sperm-egg recognition (GO:0035036)7.22104872
9microtubule depolymerization (GO:0007019)7.15718567
10spermatid nucleus differentiation (GO:0007289)7.13820462
11single strand break repair (GO:0000012)7.13155315
12multicellular organism reproduction (GO:0032504)7.13120977
13binding of sperm to zona pellucida (GO:0007339)7.05538647
14microtubule polymerization or depolymerization (GO:0031109)6.32300344
15reproduction (GO:0000003)6.29352035
16protein targeting to Golgi (GO:0000042)6.05925326
17rRNA methylation (GO:0031167)6.01938422
18calcium ion-dependent exocytosis (GO:0017156)6.01324128
19centriole replication (GO:0007099)6.01098207
20cell-cell recognition (GO:0009988)5.96435785
21spermatogenesis (GO:0007283)5.88905304
22phosphatidylethanolamine biosynthetic process (GO:0006646)5.88173382
23protein polyglutamylation (GO:0018095)5.87870879
24establishment of protein localization to Golgi (GO:0072600)5.86888028
25male gamete generation (GO:0048232)5.86822493
26axonemal dynein complex assembly (GO:0070286)5.77958642
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.61495306
28gamete generation (GO:0007276)5.49480084
29phosphatidylethanolamine metabolic process (GO:0046337)5.42828708
30centriole assembly (GO:0098534)5.13538757
31negative regulation of inclusion body assembly (GO:0090084)5.10689343
32single fertilization (GO:0007338)5.03183528
33microtubule severing (GO:0051013)5.00908276
34regulation of centriole replication (GO:0046599)5.00363805
35regulation of mesoderm development (GO:2000380)4.93816824
36rRNA modification (GO:0000154)4.92868795
37sexual reproduction (GO:0019953)4.92802228
38germ cell development (GO:0007281)4.67743452
39cilium or flagellum-dependent cell motility (GO:0001539)4.59940531
40regulation of cilium movement (GO:0003352)4.51209471
41regulation of transcription involved in cell fate commitment (GO:0060850)4.50969413
42seminiferous tubule development (GO:0072520)4.44226981
43multicellular organismal reproductive process (GO:0048609)4.39749359
44cellular process involved in reproduction in multicellular organism (GO:0022412)4.38936944
45cellular ketone body metabolic process (GO:0046950)4.38181298
46epithelial cilium movement (GO:0003351)4.30661393
47regulation of Rab GTPase activity (GO:0032313)4.28145949
48positive regulation of Rab GTPase activity (GO:0032851)4.28145949
49motile cilium assembly (GO:0044458)4.27881578
50protein localization to Golgi apparatus (GO:0034067)4.25206849
51fertilization (GO:0009566)4.13314431
52histone exchange (GO:0043486)4.06806732
53RNA destabilization (GO:0050779)3.99133872
54ketone body metabolic process (GO:1902224)3.83145336
55cilium movement (GO:0003341)3.74981650
56chromatin silencing (GO:0006342)3.73995852
57nucleus organization (GO:0006997)3.72258050
58regulation of phosphoprotein phosphatase activity (GO:0043666)3.65342297
59cell wall macromolecule metabolic process (GO:0044036)3.62362484
60regulation of inclusion body assembly (GO:0090083)3.61390806
61organic cation transport (GO:0015695)3.57038605
62coenzyme catabolic process (GO:0009109)3.53021279
63cell wall macromolecule catabolic process (GO:0016998)3.48681223
64L-serine transport (GO:0015825)3.46655844
65response to acidic pH (GO:0010447)3.43586980
66glycerol ether metabolic process (GO:0006662)3.35687379
67cerebral cortex neuron differentiation (GO:0021895)3.34786081
68protein-DNA complex disassembly (GO:0032986)3.32866363
69nucleosome disassembly (GO:0006337)3.32866363
70male meiosis (GO:0007140)3.32206873
71glomerular visceral epithelial cell development (GO:0072015)3.31094297
72centrosome duplication (GO:0051298)3.30429645
73negative regulation of Rho protein signal transduction (GO:0035024)3.23529041
74polyamine biosynthetic process (GO:0006596)3.16754051
75detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.16469059
76genitalia morphogenesis (GO:0035112)3.14276911
77glomerular epithelial cell development (GO:0072310)3.10547942
78ether metabolic process (GO:0018904)3.07505112
79cellular response to pH (GO:0071467)3.07182527
80multicellular organismal movement (GO:0050879)3.06608643
81musculoskeletal movement (GO:0050881)3.06608643
82mitochondrial fission (GO:0000266)3.06516587
83somite rostral/caudal axis specification (GO:0032525)3.04247722
84anterior/posterior axis specification, embryo (GO:0008595)2.95073581
85microtubule nucleation (GO:0007020)2.94826208
86positive regulation of gastrulation (GO:2000543)2.93198220
87histone H3-K9 demethylation (GO:0033169)2.89411105
88regulation of meiosis I (GO:0060631)2.89130563
89piRNA metabolic process (GO:0034587)2.86465632
90multicellular organismal development (GO:0007275)2.85301456
91cell migration involved in gastrulation (GO:0042074)2.85124362
92serine transport (GO:0032329)2.82558417
93cell recognition (GO:0008037)2.80025663
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79647811
95positive regulation of skeletal muscle tissue development (GO:0048643)2.79509497
96regulation of microtubule-based movement (GO:0060632)2.78242037
97histone mRNA catabolic process (GO:0071044)2.78123832
98peptidyl-threonine dephosphorylation (GO:0035970)2.77650315
99acrosome reaction (GO:0007340)10.9187966
100sperm motility (GO:0030317)10.7758035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.92347461
2CTBP2_25329375_ChIP-Seq_LNCAP_Human2.83887063
3FUS_26573619_Chip-Seq_HEK293_Human2.80950271
4EZH2_22144423_ChIP-Seq_EOC_Human2.76914729
5CTBP1_25329375_ChIP-Seq_LNCAP_Human2.67141625
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64599942
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.64599942
8CBP_20019798_ChIP-Seq_JUKART_Human2.56631228
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.56631228
10* SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.29027172
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27825367
12* SMAD3_21741376_ChIP-Seq_EPCs_Human2.27801634
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.27760731
14* SMAD4_21741376_ChIP-Seq_EPCs_Human2.20790658
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.20120722
16P300_19829295_ChIP-Seq_ESCs_Human2.15211258
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13132206
18SMAD4_21741376_ChIP-Seq_HESCs_Human2.11520701
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09388104
20ER_23166858_ChIP-Seq_MCF-7_Human2.02766503
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02371398
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99541869
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92471138
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91934651
25AR_25329375_ChIP-Seq_VCAP_Human1.90330820
26NANOG_20526341_ChIP-Seq_ESCs_Human1.89949007
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86627622
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.78803137
29ZNF274_21170338_ChIP-Seq_K562_Hela1.73430826
30TP53_18474530_ChIP-ChIP_U2OS_Human1.73036786
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70463960
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.70069520
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.63762317
34SMAD3_21741376_ChIP-Seq_ESCs_Human1.61677037
35ERA_21632823_ChIP-Seq_H3396_Human1.61196827
36GBX2_23144817_ChIP-Seq_PC3_Human1.60458789
37TAF15_26573619_Chip-Seq_HEK293_Human1.60249275
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59833036
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.58111120
40MYC_19829295_ChIP-Seq_ESCs_Human1.53285312
41SOX2_19829295_ChIP-Seq_ESCs_Human1.52637405
42NANOG_19829295_ChIP-Seq_ESCs_Human1.52637405
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.51636529
44RAC3_21632823_ChIP-Seq_H3396_Human1.50928047
45RUNX2_22187159_ChIP-Seq_PCA_Human1.50244012
46SMAD4_21799915_ChIP-Seq_A2780_Human1.48848139
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.48094521
48EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.45888440
49VDR_22108803_ChIP-Seq_LS180_Human1.43925221
50SMAD3_21741376_ChIP-Seq_HESCs_Human1.37296556
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35833277
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34386816
53OCT4_20526341_ChIP-Seq_ESCs_Human1.33589866
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33119423
55STAT3_23295773_ChIP-Seq_U87_Human1.32587111
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32479637
57CBX2_22325352_ChIP-Seq_293T-Rex_Human1.31763248
58RBPJ_21746931_ChIP-Seq_IB4_Human1.31332827
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.31089245
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30315162
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30269781
62TBL1_22424771_ChIP-Seq_293T_Human1.29290940
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.27557692
64ETV1_20927104_ChIP-Seq_GIST48_Human1.26261823
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24034669
66HNFA_21074721_ChIP-Seq_CACO-2_Human1.24008156
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22839958
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22312369
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21429097
70NFYB_21822215_ChIP-Seq_K562_Human1.20411336
71TAF2_19829295_ChIP-Seq_ESCs_Human1.19476736
72DROSHA_22980978_ChIP-Seq_HELA_Human1.18986536
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.18447641
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.16321397
75OCT1_27270436_Chip-Seq_PROSTATE_Human1.11599706
76* GATA3_21878914_ChIP-Seq_MCF-7_Human1.11462950
77KDM2B_26808549_Chip-Seq_REH_Human1.11159284
78BCAT_22108803_ChIP-Seq_LS180_Human1.10228626
79HOXB7_26014856_ChIP-Seq_BT474_Human1.10202185
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09584952
81AR_21572438_ChIP-Seq_LNCaP_Human1.08572178
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08276838
83PHF8_20622853_ChIP-Seq_HELA_Human1.07131476
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07107016
85TCF4_22108803_ChIP-Seq_LS180_Human1.06961739
86GF1_26923725_Chip-Seq_HPCs_Mouse1.06851605
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06639216
88* CTCF_27219007_Chip-Seq_Bcells_Human1.05345126
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04958009
90SMRT_27268052_Chip-Seq_Bcells_Human1.04778011
91* ERG_20517297_ChIP-Seq_VCAP_Human1.04609394
92AHR_22903824_ChIP-Seq_MCF-7_Human1.03672457
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03174743
94TCF4_23295773_ChIP-Seq_U87_Human1.02265511
95CEBPB_22108803_ChIP-Seq_LS180_Human1.02243282
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00916457
97FOXH1_21741376_ChIP-Seq_ESCs_Human1.00652991
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.00626520
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00621625
100CDX2_22108803_ChIP-Seq_LS180_Human1.00597809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.04608222
2MP0005377_hearing/vestibular/ear_phenot3.78097094
3MP0003878_abnormal_ear_physiology3.78097094
4MP0001929_abnormal_gametogenesis3.75711057
5MP0005670_abnormal_white_adipose3.58661596
6MP0003890_abnormal_embryonic-extraembry3.54797339
7MP0003718_maternal_effect2.86541843
8MP0001348_abnormal_lacrimal_gland2.72480966
9MP0005394_taste/olfaction_phenotype2.65032435
10MP0005499_abnormal_olfactory_system2.65032435
11MP0002161_abnormal_fertility/fecundity2.32638645
12MP0003119_abnormal_digestive_system2.31341725
13MP0002132_abnormal_respiratory_system2.27725514
14MP0001984_abnormal_olfaction2.26624400
15MP0008004_abnormal_stomach_pH2.05751657
16MP0005410_abnormal_fertilization10.8485388
17MP0002210_abnormal_sex_determination1.96461656
18MP0001485_abnormal_pinna_reflex1.91787012
19MP0002234_abnormal_pharynx_morphology1.85778049
20MP0009053_abnormal_anal_canal1.82202051
21MP0002282_abnormal_trachea_morphology1.79975241
22MP0001145_abnormal_male_reproductive1.61097797
23MP0000653_abnormal_sex_gland1.53906817
24MP0005423_abnormal_somatic_nervous1.52785418
25MP0002138_abnormal_hepatobiliary_system1.50080496
26MP0002127_abnormal_cardiovascular_syste1.47101340
27MP0003646_muscle_fatigue1.42362904
28MP0005367_renal/urinary_system_phenotyp1.35678381
29MP0000516_abnormal_urinary_system1.35678381
30MP0008789_abnormal_olfactory_epithelium1.33242249
31MP0000049_abnormal_middle_ear1.32138673
32MP0003011_delayed_dark_adaptation1.29890115
33MP0008877_abnormal_DNA_methylation1.29476998
34MP0008995_early_reproductive_senescence1.29102968
35MP0005379_endocrine/exocrine_gland_phen1.25570061
36MP0001486_abnormal_startle_reflex1.22719846
37MP0002249_abnormal_larynx_morphology1.22057154
38MP0000678_abnormal_parathyroid_gland1.21248143
39MP0006292_abnormal_olfactory_placode1.21220337
40MP0003136_yellow_coat_color1.19155039
41MP0002254_reproductive_system_inflammat1.18246212
42MP0005395_other_phenotype1.18206668
43MP0004085_abnormal_heartbeat1.04516930
44MP0003693_abnormal_embryo_hatching0.99152603
45MP0001963_abnormal_hearing_physiology0.98316295
46MP0005551_abnormal_eye_electrophysiolog0.91243154
47MP0001968_abnormal_touch/_nociception0.89890359
48MP0005253_abnormal_eye_physiology0.88278756
49MP0003936_abnormal_reproductive_system0.87622207
50MP0004957_abnormal_blastocyst_morpholog0.82696412
51MP0003283_abnormal_digestive_organ0.82534308
52MP0004510_myositis0.82033373
53MP0003937_abnormal_limbs/digits/tail_de0.80812591
54MP0001293_anophthalmia0.80700179
55MP0000026_abnormal_inner_ear0.80162677
56MP0004133_heterotaxia0.79897823
57MP0000534_abnormal_ureter_morphology0.79878473
58MP0003077_abnormal_cell_cycle0.79333450
59MP0003195_calcinosis0.78923596
60MP0004742_abnormal_vestibular_system0.78504129
61MP0002160_abnormal_reproductive_system0.76841657
62MP0001666_abnormal_nutrient_absorption0.72554349
63MP0004264_abnormal_extraembryonic_tissu0.69998553
64MP0002735_abnormal_chemical_nociception0.68924948
65MP0002102_abnormal_ear_morphology0.68700714
66MP0003137_abnormal_impulse_conducting0.68424825
67MP0002109_abnormal_limb_morphology0.68392590
68MP0002084_abnormal_developmental_patter0.67773159
69MP0002932_abnormal_joint_morphology0.64324994
70MP0005647_abnormal_sex_gland0.63076886
71MP0001765_abnormal_ion_homeostasis0.62341880
72MP0001286_abnormal_eye_development0.61575160
73MP0009115_abnormal_fat_cell0.61262390
74MP0005391_vision/eye_phenotype0.60696467
75MP0002085_abnormal_embryonic_tissue0.58945457
76MP0009697_abnormal_copulation0.58828852
77MP0000470_abnormal_stomach_morphology0.58177393
78MP0003699_abnormal_female_reproductive0.57777648
79MP0000955_abnormal_spinal_cord0.57570615
80MP0001672_abnormal_embryogenesis/_devel0.56812749
81MP0005380_embryogenesis_phenotype0.56812749
82MP0002067_abnormal_sensory_capabilities0.55052013
83MP0003385_abnormal_body_wall0.53795288
84MP0010030_abnormal_orbit_morphology0.52920321
85MP0002822_catalepsy0.52100669
86MP0003315_abnormal_perineum_morphology0.51861510
87MP0003880_abnormal_central_pattern0.50934107
88MP0005248_abnormal_Harderian_gland0.50783777
89MP0002229_neurodegeneration0.50733260
90MP0002115_abnormal_skeleton_extremities0.50421992
91MP0005310_abnormal_salivary_gland0.48536972
92MP0003879_abnormal_hair_cell0.47987967
93MP0001905_abnormal_dopamine_level0.47723454
94MP0004084_abnormal_cardiac_muscle0.46410247
95MP0003935_abnormal_craniofacial_develop0.46279013
96MP0001119_abnormal_female_reproductive0.45967647
97MP0000762_abnormal_tongue_morphology0.45525015
98MP0000428_abnormal_craniofacial_morphol0.45396268
99MP0002736_abnormal_nociception_after0.44883772
100MP0003861_abnormal_nervous_system0.43081136

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.74393921
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.36048227
3Absent/shortened dynein arms (HP:0200106)5.36048227
4Congenital malformation of the right heart (HP:0011723)4.30615828
5Double outlet right ventricle (HP:0001719)4.30615828
6Abnormal ciliary motility (HP:0012262)4.26988474
7Abnormal respiratory motile cilium physiology (HP:0012261)4.17769000
8Bony spicule pigmentary retinopathy (HP:0007737)4.17535433
9Attenuation of retinal blood vessels (HP:0007843)4.08580976
10Tubulointerstitial nephritis (HP:0001970)4.06684462
11Bell-shaped thorax (HP:0001591)4.02637277
12Abnormal respiratory epithelium morphology (HP:0012253)3.74882723
13Abnormal respiratory motile cilium morphology (HP:0005938)3.74882723
14Resting tremor (HP:0002322)3.65192768
15Chronic hepatic failure (HP:0100626)3.61974049
16Infertility (HP:0000789)3.57305238
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55163534
18Abnormality of the parathyroid morphology (HP:0011766)3.53561615
19Hypoalphalipoproteinemia (HP:0003233)3.50232734
20Abdominal situs inversus (HP:0003363)3.48919494
21Abnormality of abdominal situs (HP:0011620)3.48919494
22Asymmetric septal hypertrophy (HP:0001670)3.28517621
23Male infertility (HP:0003251)3.25882705
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.21821291
25Abnormality of the ischium (HP:0003174)3.11965559
26Abnormality of macular pigmentation (HP:0008002)2.95271870
27Impulsivity (HP:0100710)2.94987365
28Abnormal rod and cone electroretinograms (HP:0008323)2.93867106
29Facial shape deformation (HP:0011334)2.84949287
30Potter facies (HP:0002009)2.84949287
31Hyperkalemia (HP:0002153)2.80831823
32Hypoplastic ischia (HP:0003175)2.79675360
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76401030
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69411497
35Rhinitis (HP:0012384)2.61938368
36Postural instability (HP:0002172)2.59813066
37Optic nerve hypoplasia (HP:0000609)2.57907950
38Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.54723531
39Cone-rod dystrophy (HP:0000548)2.53651640
40Intestinal atresia (HP:0011100)2.51566831
41Hypoplasia of the thymus (HP:0000778)2.50807204
42Esophageal atresia (HP:0002032)2.49972712
43Gonadal dysgenesis (HP:0000133)2.49641920
44Abnormal connection of the cardiac segments (HP:0011545)2.48648699
45Abnormal ventriculo-arterial connection (HP:0011563)2.48648699
46Transposition of the great arteries (HP:0001669)2.48648699
47Abnormality of the aortic arch (HP:0012303)2.48421291
48Nasal polyposis (HP:0100582)2.47501700
49Mixed hearing impairment (HP:0000410)2.45782518
50Azoospermia (HP:0000027)2.45517806
51Enlarged epiphyses (HP:0010580)2.44666126
52Abnormal spermatogenesis (HP:0008669)2.44635744
53Anal stenosis (HP:0002025)2.36925614
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36461738
55Abnormality of the pubic bones (HP:0003172)2.27629061
56Oligodactyly (hands) (HP:0001180)2.27170876
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.23020122
58Anophthalmia (HP:0000528)2.17967222
59Septo-optic dysplasia (HP:0100842)2.15680616
60Abnormality of the costochondral junction (HP:0000919)2.14811816
61Short middle phalanx of the 5th finger (HP:0004220)2.13698135
62Absent radius (HP:0003974)2.13441758
63Gastrointestinal atresia (HP:0002589)2.09859222
64Abnormal umbilical cord blood vessels (HP:0011403)2.08944292
65Single umbilical artery (HP:0001195)2.08944292
66Abnormality of the fetal cardiovascular system (HP:0010948)2.08944292
67Hypophosphatemic rickets (HP:0004912)2.08501397
68Abnormal urine output (HP:0012590)2.07505808
69Nephronophthisis (HP:0000090)2.07351836
70Rectal fistula (HP:0100590)2.06420762
71Rectovaginal fistula (HP:0000143)2.06420762
72Progressive cerebellar ataxia (HP:0002073)2.06024615
73Epiphyseal dysplasia (HP:0002656)2.05192360
74Progressive sensorineural hearing impairment (HP:0000408)2.03966810
75Absent forearm bone (HP:0003953)1.98908317
76Aplasia involving forearm bones (HP:0009822)1.98908317
77Abnormality of the nasal mucosa (HP:0000433)1.97633559
78Truncal obesity (HP:0001956)1.96499707
79Abnormal drinking behavior (HP:0030082)1.95372696
80Polydipsia (HP:0001959)1.95372696
81Abnormality of the ileum (HP:0001549)1.94969227
82Portal hypertension (HP:0001409)1.94287752
83Intestinal fistula (HP:0100819)1.90817761
84Anterior segment dysgenesis (HP:0007700)1.90645538
85Generalized aminoaciduria (HP:0002909)1.90311075
86Insulin-resistant diabetes mellitus (HP:0000831)1.86256949
87Synostosis of carpal bones (HP:0005048)1.85476053
88Duodenal stenosis (HP:0100867)1.84777597
89Small intestinal stenosis (HP:0012848)1.84777597
90Meckel diverticulum (HP:0002245)1.84513339
91Abnormality of the nasal septum (HP:0000419)1.84439871
92Abnormality of the duodenum (HP:0002246)1.84428320
93Abnormality of dental color (HP:0011073)1.83200002
94Abnormal pancreas size (HP:0012094)1.82740480
95Stage 5 chronic kidney disease (HP:0003774)1.82399644
96Preauricular pit (HP:0004467)1.80802712
97Periauricular skin pits (HP:0100277)1.80802712
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.79990015
99Hypoplastic pelvis (HP:0008839)1.79909190
100Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.78423597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.70150868
2TESK13.71489418
3DDR23.51638694
4PLK23.23828649
5INSRR3.20953542
6ACVR1B3.07253782
7MAP4K23.02313444
8BRD42.90525516
9BMPR1B2.82265952
10PNCK2.77975134
11STK38L2.67113120
12PRKD32.43643957
13STK382.30392234
14PINK12.10842051
15ERBB42.04469224
16CAMK1G1.77209503
17WNK31.70154715
18MAP3K91.65846432
19TRIM281.55195983
20MAPK151.49456382
21BRAF1.38568876
22MAP3K41.34813158
23PBK1.23651933
24PIK3CG1.22777195
25MKNK21.21231326
26BRSK21.19226486
27NEK61.16110696
28PTK2B1.06985191
29WNK11.06760541
30CDK71.06414232
31TGFBR11.06025914
32MST1R0.98643715
33LATS10.89804432
34LATS20.89778196
35PDK10.89306420
36FRK0.86005518
37PDPK10.85137496
38MARK30.82665641
39PRKAA20.82105769
40NUAK10.78790967
41BRSK10.78191986
42AKT30.77748332
43ZAK0.74766685
44ARAF0.61915919
45PRKG10.61897212
46GRK10.61439425
47CDK120.61361494
48TNIK0.58149941
49ROCK10.57754245
50CDK30.56947235
51STK390.56933226
52MAP3K80.56586535
53PRKG20.56294965
54DYRK1B0.51515334
55MAP2K70.47054665
56PKN20.46814451
57NEK20.43041845
58TLK10.42896559
59STK100.41243422
60FLT30.39907799
61MKNK10.39243483
62CHEK10.38877248
63TIE10.38744851
64CDK20.38704743
65PLK10.37572379
66ERBB30.36258247
67WNK40.36180936
68MAPK10.35789102
69CAMK10.35560318
70CAMK1D0.34694746
71CDK10.33242330
72MET0.32998376
73GSK3B0.32349843
74STK30.32052593
75CDK90.31878273
76TYRO30.31743378
77CDK40.31737929
78MYLK0.31196269
79TTK0.30805113
80MST40.30218729
81SGK2230.27874016
82SGK4940.27874016
83OXSR10.26154511
84PRKCG0.25575841
85EIF2AK30.24567394
86RPS6KA10.24486305
87FGFR10.23796093
88PLK30.22047285
89PRKCQ0.22027885
90CDC70.21888837
91RPS6KA20.20691585
92AURKA0.20362164
93PRKCE0.19289977
94ATM0.18223910
95MAPK130.17119925
96PAK10.17044994
97VRK10.16784114
98SRPK10.16482244
99FER0.15608601
100MELK0.15500312

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.10127413
2Fatty acid biosynthesis_Homo sapiens_hsa000614.71685837
3Olfactory transduction_Homo sapiens_hsa047404.26409550
4Butanoate metabolism_Homo sapiens_hsa006503.60226845
5Hedgehog signaling pathway_Homo sapiens_hsa043402.12825983
6RNA transport_Homo sapiens_hsa030132.04080522
7Basal transcription factors_Homo sapiens_hsa030221.96707502
8Fatty acid metabolism_Homo sapiens_hsa012121.94002329
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.85160820
10Dorso-ventral axis formation_Homo sapiens_hsa043201.80610876
11Fanconi anemia pathway_Homo sapiens_hsa034601.77850903
12Fatty acid degradation_Homo sapiens_hsa000711.77487108
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.76789647
14Propanoate metabolism_Homo sapiens_hsa006401.68844909
15Phototransduction_Homo sapiens_hsa047441.68290421
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62555171
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53979805
18Oocyte meiosis_Homo sapiens_hsa041141.52595874
19Taste transduction_Homo sapiens_hsa047421.41294056
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19186897
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17380805
22Protein digestion and absorption_Homo sapiens_hsa049741.12752857
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12569663
24TGF-beta signaling pathway_Homo sapiens_hsa043501.03479518
25PPAR signaling pathway_Homo sapiens_hsa033201.02831980
26Arginine and proline metabolism_Homo sapiens_hsa003301.02195815
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01606029
28Calcium signaling pathway_Homo sapiens_hsa040201.01567829
29Wnt signaling pathway_Homo sapiens_hsa043100.99902168
30Phenylalanine metabolism_Homo sapiens_hsa003600.99282677
31Basal cell carcinoma_Homo sapiens_hsa052170.98189476
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93919103
33Nitrogen metabolism_Homo sapiens_hsa009100.84034947
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81879404
35Arginine biosynthesis_Homo sapiens_hsa002200.81860764
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81225861
37mRNA surveillance pathway_Homo sapiens_hsa030150.80311155
38Fat digestion and absorption_Homo sapiens_hsa049750.79885584
39cAMP signaling pathway_Homo sapiens_hsa040240.79077510
40Type II diabetes mellitus_Homo sapiens_hsa049300.78320005
41Non-homologous end-joining_Homo sapiens_hsa034500.78179466
42RNA degradation_Homo sapiens_hsa030180.76860558
43Retinol metabolism_Homo sapiens_hsa008300.76137695
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73912883
45Pyruvate metabolism_Homo sapiens_hsa006200.73419002
46Gap junction_Homo sapiens_hsa045400.72625736
47Steroid biosynthesis_Homo sapiens_hsa001000.71941794
48Selenocompound metabolism_Homo sapiens_hsa004500.71741044
49ABC transporters_Homo sapiens_hsa020100.71415028
50Cell cycle_Homo sapiens_hsa041100.69048494
51Purine metabolism_Homo sapiens_hsa002300.68979510
52Gastric acid secretion_Homo sapiens_hsa049710.67995227
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67098423
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64754948
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63943381
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62308387
57Circadian entrainment_Homo sapiens_hsa047130.61622135
58Glycerolipid metabolism_Homo sapiens_hsa005610.61003479
59Circadian rhythm_Homo sapiens_hsa047100.59050403
60Salivary secretion_Homo sapiens_hsa049700.59035089
61Inositol phosphate metabolism_Homo sapiens_hsa005620.58177177
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56424655
63Renin-angiotensin system_Homo sapiens_hsa046140.56201012
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.55219990
65Hippo signaling pathway_Homo sapiens_hsa043900.54719306
66Caffeine metabolism_Homo sapiens_hsa002320.53706798
67Tight junction_Homo sapiens_hsa045300.53001534
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.52465173
69Type I diabetes mellitus_Homo sapiens_hsa049400.50657815
70Endocytosis_Homo sapiens_hsa041440.48470828
71Antigen processing and presentation_Homo sapiens_hsa046120.47137410
72Autoimmune thyroid disease_Homo sapiens_hsa053200.46158117
73Homologous recombination_Homo sapiens_hsa034400.45783411
74Morphine addiction_Homo sapiens_hsa050320.45277619
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44694268
76Allograft rejection_Homo sapiens_hsa053300.43574233
77Chemical carcinogenesis_Homo sapiens_hsa052040.42843835
78Nicotine addiction_Homo sapiens_hsa050330.42084266
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42043053
80Melanogenesis_Homo sapiens_hsa049160.39815490
81Graft-versus-host disease_Homo sapiens_hsa053320.39585570
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38983602
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38608764
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37185771
85beta-Alanine metabolism_Homo sapiens_hsa004100.35639883
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34902245
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33467101
88Adherens junction_Homo sapiens_hsa045200.33270544
89Renin secretion_Homo sapiens_hsa049240.32310772
90Tryptophan metabolism_Homo sapiens_hsa003800.32230521
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32082575
92Base excision repair_Homo sapiens_hsa034100.31279069
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.30419242
94ECM-receptor interaction_Homo sapiens_hsa045120.29638882
95Metabolic pathways_Homo sapiens_hsa011000.29401624
96Oxytocin signaling pathway_Homo sapiens_hsa049210.29245268
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29136294
98Peroxisome_Homo sapiens_hsa041460.27774464
99Tyrosine metabolism_Homo sapiens_hsa003500.27727089
100Vitamin B6 metabolism_Homo sapiens_hsa007500.27352061

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