OR5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phospholipid scrambling (GO:0017121)9.59091160
2mating behavior (GO:0007617)7.71581354
3L-serine transport (GO:0015825)7.68350052
4genitalia morphogenesis (GO:0035112)6.64705088
5serine transport (GO:0032329)6.51133693
6regulation of mesoderm development (GO:2000380)6.38786977
7anterior/posterior axis specification, embryo (GO:0008595)6.31329423
8somite rostral/caudal axis specification (GO:0032525)5.90875503
9endoderm formation (GO:0001706)5.58813305
10chromatin remodeling at centromere (GO:0031055)5.33129070
11anterior/posterior axis specification (GO:0009948)5.22047803
12primitive streak formation (GO:0090009)5.16258830
13CENP-A containing nucleosome assembly (GO:0034080)5.09472110
14synapsis (GO:0007129)4.95025413
15negative regulation of activin receptor signaling pathway (GO:0032926)4.80226933
16embryonic axis specification (GO:0000578)4.71778120
17cell migration involved in gastrulation (GO:0042074)4.70682092
18sequestering of extracellular ligand from receptor (GO:0035581)4.67424297
19histone exchange (GO:0043486)4.37961503
20single strand break repair (GO:0000012)4.21085944
21DNA ligation (GO:0006266)4.07620964
22cellular response to hepatocyte growth factor stimulus (GO:0035729)3.96921408
23response to hepatocyte growth factor (GO:0035728)3.96921408
24negative regulation of axon extension involved in axon guidance (GO:0048843)3.94699265
25fat-soluble vitamin catabolic process (GO:0042363)3.94021249
26vitamin catabolic process (GO:0009111)3.94021249
27signal transduction involved in regulation of gene expression (GO:0023019)3.93594746
28embryonic pattern specification (GO:0009880)3.87910092
29RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.85710501
30atrial cardiac muscle cell action potential (GO:0086014)3.82791334
31prenylation (GO:0097354)3.78277064
32protein prenylation (GO:0018342)3.78277064
33DNA replication-independent nucleosome organization (GO:0034724)3.77240133
34DNA replication-independent nucleosome assembly (GO:0006336)3.77240133
35DNA replication-dependent nucleosome assembly (GO:0006335)3.76836375
36DNA replication-dependent nucleosome organization (GO:0034723)3.76836375
37positive regulation of cGMP biosynthetic process (GO:0030828)3.74426357
38negative regulation of cell fate specification (GO:0009996)3.70750247
39replication fork processing (GO:0031297)3.69603199
40positive regulation of cGMP metabolic process (GO:0030825)3.61174448
41Rap protein signal transduction (GO:0032486)3.60422251
42gastrulation (GO:0007369)3.53929534
43phosphatidylserine metabolic process (GO:0006658)3.53448998
44regulation of cGMP biosynthetic process (GO:0030826)3.49241503
45negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.48407309
46negative regulation of execution phase of apoptosis (GO:1900118)3.48345522
47histone mRNA catabolic process (GO:0071044)3.46963540
48branched-chain amino acid catabolic process (GO:0009083)3.43161282
49alditol phosphate metabolic process (GO:0052646)3.42418494
50regulation of activin receptor signaling pathway (GO:0032925)3.40409176
51centriole replication (GO:0007099)3.36371169
52heterochromatin organization (GO:0070828)3.35910622
53regulation of cGMP metabolic process (GO:0030823)3.35444211
54regulation of membrane lipid distribution (GO:0097035)3.33663545
55cellular response to interleukin-6 (GO:0071354)3.30465752
56axis specification (GO:0009798)3.29281658
57regulation of gastrulation (GO:0010470)3.29127606
58positive regulation of gastrulation (GO:2000543)3.25342675
59female gonad development (GO:0008585)3.20508939
60seminiferous tubule development (GO:0072520)3.14852531
61dorsal/ventral axis specification (GO:0009950)3.06923104
62response to pheromone (GO:0019236)3.06481045
63regulation of axon extension involved in axon guidance (GO:0048841)3.02427361
64negative regulation of axon guidance (GO:1902668)3.01352575
65aggressive behavior (GO:0002118)2.98623048
66negative regulation of embryonic development (GO:0045992)2.97985716
67kinetochore assembly (GO:0051382)2.94789361
68positive regulation of mRNA catabolic process (GO:0061014)2.94515160
69negative regulation of cell fate commitment (GO:0010454)2.91490372
70signal peptide processing (GO:0006465)2.88364801
71type B pancreatic cell development (GO:0003323)2.87674430
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.86929034
73resolution of meiotic recombination intermediates (GO:0000712)2.83444777
74positive regulation of protein autophosphorylation (GO:0031954)2.79957712
75myeloid leukocyte mediated immunity (GO:0002444)2.79450445
76maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78147337
77DNA deamination (GO:0045006)2.77388972
78positive regulation of cardiac muscle cell proliferation (GO:0060045)2.76473942
79kinetochore organization (GO:0051383)2.75679474
80wound healing, spreading of epidermal cells (GO:0035313)2.74199382
81response to interleukin-6 (GO:0070741)2.71837332
82branch elongation of an epithelium (GO:0060602)2.71232688
83response to BMP (GO:0071772)2.71016215
84cellular response to BMP stimulus (GO:0071773)2.71016215
85very long-chain fatty acid metabolic process (GO:0000038)2.68641828
86extracellular negative regulation of signal transduction (GO:1900116)2.68245658
87extracellular regulation of signal transduction (GO:1900115)2.68245658
88protein K6-linked ubiquitination (GO:0085020)2.65267153
89limb bud formation (GO:0060174)2.63665441
90pseudouridine synthesis (GO:0001522)2.63257739
91mitotic sister chromatid cohesion (GO:0007064)2.60748092
92neutral amino acid transport (GO:0015804)2.60746507
93nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57528478
94regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.57396748
95establishment of integrated proviral latency (GO:0075713)2.56537043
96regulation of collateral sprouting (GO:0048670)2.55704998
97interferon-gamma production (GO:0032609)2.55693871
98regulation of cell communication by electrical coupling (GO:0010649)2.55555270
99positive regulation of cardiac muscle tissue growth (GO:0055023)2.54097652
100regulation of axon guidance (GO:1902667)2.52882080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.05604008
2ZNF274_21170338_ChIP-Seq_K562_Hela3.19959791
3GBX2_23144817_ChIP-Seq_PC3_Human3.09404923
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.90211312
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.82045504
6* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75360605
7SMAD3_21741376_ChIP-Seq_HESCs_Human2.69488426
8P300_19829295_ChIP-Seq_ESCs_Human2.68943058
9SMAD3_21741376_ChIP-Seq_EPCs_Human2.57329087
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55261091
11TAF15_26573619_Chip-Seq_HEK293_Human2.52849924
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41109550
13SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.30800025
14VDR_22108803_ChIP-Seq_LS180_Human2.23445774
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21969513
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18769055
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18263744
18SMAD4_21741376_ChIP-Seq_HESCs_Human2.12691711
19FUS_26573619_Chip-Seq_HEK293_Human2.10656135
20EZH2_22144423_ChIP-Seq_EOC_Human2.08718784
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07446380
22EWS_26573619_Chip-Seq_HEK293_Human2.01413302
23BCAT_22108803_ChIP-Seq_LS180_Human2.00758615
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90551462
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90074510
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89648955
27SMAD4_21741376_ChIP-Seq_EPCs_Human1.87965427
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81947507
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.80476088
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.79771503
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76286627
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70967508
33IGF1R_20145208_ChIP-Seq_DFB_Human1.66716729
34ER_23166858_ChIP-Seq_MCF-7_Human1.64672874
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64090042
36ELK1_19687146_ChIP-ChIP_HELA_Human1.60795700
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59794417
38AR_25329375_ChIP-Seq_VCAP_Human1.58814462
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55911701
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53765284
41SMAD4_21799915_ChIP-Seq_A2780_Human1.50993369
42TCF4_22108803_ChIP-Seq_LS180_Human1.50629632
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45010843
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44444118
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44160933
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.41082235
47KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39524162
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36451091
49RUNX2_22187159_ChIP-Seq_PCA_Human1.32896527
50TCF4_23295773_ChIP-Seq_U87_Human1.30706958
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30468869
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30455262
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29934570
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29206623
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29004301
56* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28455586
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28372194
58CBP_20019798_ChIP-Seq_JUKART_Human1.28372194
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28194576
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28135074
61STAT3_23295773_ChIP-Seq_U87_Human1.28133956
62TP53_22573176_ChIP-Seq_HFKS_Human1.25680565
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.25546417
64EOMES_21245162_ChIP-Seq_HESCs_Human1.25459392
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25102144
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24399180
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22874669
68NANOG_19829295_ChIP-Seq_ESCs_Human1.22652816
69SOX2_19829295_ChIP-Seq_ESCs_Human1.22652816
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21259083
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.19915840
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19844398
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.19794061
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18930783
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.17744370
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.16805780
77TP53_16413492_ChIP-PET_HCT116_Human1.14992604
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13666934
79CDX2_22108803_ChIP-Seq_LS180_Human1.13211598
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.11198617
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10176867
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.09822973
83MYC_18940864_ChIP-ChIP_HL60_Human1.06253995
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06054151
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06054151
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.05912703
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05514792
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04902492
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04902492
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04902492
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04853724
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04581798
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03810620
94TP53_18474530_ChIP-ChIP_U2OS_Human1.01068481
95KDM2B_26808549_Chip-Seq_REH_Human1.00960826
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99627327
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99285236
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98639831
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.97401092
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.96980774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry7.53190788
2MP0008877_abnormal_DNA_methylation4.67586721
3MP0002254_reproductive_system_inflammat4.33751972
4MP0003787_abnormal_imprinting4.23786388
5MP0001984_abnormal_olfaction3.91168077
6MP0005499_abnormal_olfactory_system3.28997676
7MP0005394_taste/olfaction_phenotype3.28997676
8MP0003119_abnormal_digestive_system3.19811043
9MP0002102_abnormal_ear_morphology2.81621362
10MP0006054_spinal_hemorrhage2.78397711
11MP0008004_abnormal_stomach_pH2.73117135
12MP0002736_abnormal_nociception_after2.67342506
13MP0003880_abnormal_central_pattern2.52416291
14MP0003121_genomic_imprinting2.09062571
15MP0005646_abnormal_pituitary_gland2.03204802
16MP0010094_abnormal_chromosome_stability1.98911396
17MP0008058_abnormal_DNA_repair1.91268966
18MP0001968_abnormal_touch/_nociception1.86967968
19MP0003123_paternal_imprinting1.77910109
20MP0006072_abnormal_retinal_apoptosis1.74007340
21MP0008932_abnormal_embryonic_tissue1.71946287
22MP0005551_abnormal_eye_electrophysiolog1.65122980
23MP0002837_dystrophic_cardiac_calcinosis1.63804702
24MP0004133_heterotaxia1.56781255
25MP0004957_abnormal_blastocyst_morpholog1.56485566
26MP0001485_abnormal_pinna_reflex1.53188048
27MP0006292_abnormal_olfactory_placode1.44217914
28MP0001502_abnormal_circadian_rhythm1.38575983
29MP0003937_abnormal_limbs/digits/tail_de1.37538411
30MP0000538_abnormal_urinary_bladder1.36420879
31MP0005275_abnormal_skin_tensile1.35742647
32MP0005423_abnormal_somatic_nervous1.33093551
33MP0004272_abnormal_basement_membrane1.32941761
34MP0001293_anophthalmia1.29375559
35MP0000462_abnormal_digestive_system1.27567368
36MP0003806_abnormal_nucleotide_metabolis1.25626434
37MP0002084_abnormal_developmental_patter1.24350547
38MP0004215_abnormal_myocardial_fiber1.20965156
39MP0001529_abnormal_vocalization1.18363748
40MP0005253_abnormal_eye_physiology1.18228986
41MP0008789_abnormal_olfactory_epithelium1.18077698
42MP0002111_abnormal_tail_morphology1.12379981
43MP0002090_abnormal_vision1.08750792
44MP0003279_aneurysm1.08320034
45MP0009780_abnormal_chondrocyte_physiolo1.04200111
46MP0000427_abnormal_hair_cycle1.03668307
47MP0003195_calcinosis1.02735291
48MP0003385_abnormal_body_wall1.01122978
49MP0000569_abnormal_digit_pigmentation1.00649446
50MP0005367_renal/urinary_system_phenotyp1.00558894
51MP0000516_abnormal_urinary_system1.00558894
52MP0003137_abnormal_impulse_conducting1.00187644
53MP0003941_abnormal_skin_development0.91462859
54MP0003943_abnormal_hepatobiliary_system0.90857423
55MP0002210_abnormal_sex_determination0.84353018
56MP0002234_abnormal_pharynx_morphology0.83913372
57MP0003718_maternal_effect0.83701585
58MP0006276_abnormal_autonomic_nervous0.83331287
59MP0002160_abnormal_reproductive_system0.82679589
60MP0001286_abnormal_eye_development0.82239019
61MP0005389_reproductive_system_phenotype0.82213027
62MP0005647_abnormal_sex_gland0.81289460
63MP0000647_abnormal_sebaceous_gland0.80032272
64MP0003936_abnormal_reproductive_system0.79878809
65MP0002109_abnormal_limb_morphology0.78975987
66MP0002332_abnormal_exercise_endurance0.78680351
67MP0004145_abnormal_muscle_electrophysio0.78543732
68MP0003136_yellow_coat_color0.77869313
69MP0003566_abnormal_cell_adhesion0.77645195
70MP0002734_abnormal_mechanical_nocicepti0.76991061
71MP0003111_abnormal_nucleus_morphology0.76796374
72MP0003283_abnormal_digestive_organ0.75221853
73MP0001672_abnormal_embryogenesis/_devel0.73999841
74MP0005380_embryogenesis_phenotype0.73999841
75MP0002938_white_spotting0.72369295
76MP0002085_abnormal_embryonic_tissue0.70875006
77MP0002233_abnormal_nose_morphology0.70553642
78MP0001929_abnormal_gametogenesis0.69768704
79MP0002751_abnormal_autonomic_nervous0.69481371
80MP0008872_abnormal_physiological_respon0.68685755
81MP0000653_abnormal_sex_gland0.68117192
82MP0002653_abnormal_ependyma_morphology0.67768727
83MP0000639_abnormal_adrenal_gland0.67616025
84MP0001145_abnormal_male_reproductive0.66023418
85MP0004085_abnormal_heartbeat0.63953871
86MP0000383_abnormal_hair_follicle0.60935678
87MP0001486_abnormal_startle_reflex0.60293152
88MP0010030_abnormal_orbit_morphology0.60251621
89MP0001177_atelectasis0.60002854
90MP0008438_abnormal_cutaneous_collagen0.59323539
91MP0003698_abnormal_male_reproductive0.58671788
92MP0002184_abnormal_innervation0.57501271
93MP0005391_vision/eye_phenotype0.55231322
94MP0001915_intracranial_hemorrhage0.54706582
95MP0008007_abnormal_cellular_replicative0.53712353
96MP0000372_irregular_coat_pigmentation0.53556828
97MP0002752_abnormal_somatic_nervous0.52459452
98MP0009250_abnormal_appendicular_skeleto0.52150227
99MP0001730_embryonic_growth_arrest0.51782510
100MP0000358_abnormal_cell_content/0.51749918

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.21005534
2Rectal fistula (HP:0100590)3.98176037
3Rectovaginal fistula (HP:0000143)3.98176037
4Bifid tongue (HP:0010297)3.88818674
5Abnormal biliary tract physiology (HP:0012439)3.66625470
6Bile duct proliferation (HP:0001408)3.66625470
7Septo-optic dysplasia (HP:0100842)3.55349934
8Abnormality of the fetal cardiovascular system (HP:0010948)3.44114665
9Abnormal umbilical cord blood vessels (HP:0011403)3.44114665
10Single umbilical artery (HP:0001195)3.44114665
11Intestinal fistula (HP:0100819)3.29141266
12Vaginal fistula (HP:0004320)3.24984416
13Gonadal dysgenesis (HP:0000133)3.22521232
14Intestinal atresia (HP:0011100)3.03072053
15Absent radius (HP:0003974)2.86952175
16Pancreatic cysts (HP:0001737)2.86552543
17Abolished electroretinogram (ERG) (HP:0000550)2.82430415
18Asplenia (HP:0001746)2.70711080
19Aplasia involving forearm bones (HP:0009822)2.68494504
20Absent forearm bone (HP:0003953)2.68494504
21Medial flaring of the eyebrow (HP:0010747)2.63799053
22Abnormality of midbrain morphology (HP:0002418)2.63696903
23Molar tooth sign on MRI (HP:0002419)2.63696903
24Gonadotropin excess (HP:0000837)2.61763507
25Hypoplastic pelvis (HP:0008839)2.55141881
26Aplasia/Hypoplasia of the spleen (HP:0010451)2.52255175
27Increased number of teeth (HP:0011069)2.51855753
28Anal stenosis (HP:0002025)2.47540043
29Abnormal auditory evoked potentials (HP:0006958)2.46138246
30Progressive external ophthalmoplegia (HP:0000590)2.45234610
31Abnormal pancreas size (HP:0012094)2.42888303
32Preaxial foot polydactyly (HP:0001841)2.40829059
33Abnormal lung lobation (HP:0002101)2.37803047
34Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37173501
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.34286032
36Pancreatic islet-cell hyperplasia (HP:0004510)2.33070328
37Mesomelia (HP:0003027)2.32428006
38Progressive inability to walk (HP:0002505)2.30595746
39Abnormality of the ileum (HP:0001549)2.30263257
40Genital tract atresia (HP:0001827)2.29135093
41Carpal bone hypoplasia (HP:0001498)2.28911992
42Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27439962
43Abnormality of chromosome stability (HP:0003220)2.27231775
44Abnormality of the umbilical cord (HP:0010881)2.27139242
45Microretrognathia (HP:0000308)2.26969720
46Double outlet right ventricle (HP:0001719)2.21303029
47Congenital malformation of the right heart (HP:0011723)2.21303029
48Vaginal atresia (HP:0000148)2.20238461
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.20108441
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19684667
51Meckel diverticulum (HP:0002245)2.16001351
52Abnormality of the astrocytes (HP:0100707)2.14930472
53Astrocytoma (HP:0009592)2.14930472
54Abnormality of abdominal situs (HP:0011620)2.13306350
55Abdominal situs inversus (HP:0003363)2.13306350
56Attenuation of retinal blood vessels (HP:0007843)2.11768000
57Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.08913724
58Short middle phalanx of the 5th finger (HP:0004220)2.06057744
59Hypoproteinemia (HP:0003075)2.05885740
60Short hallux (HP:0010109)2.04559443
61Dyschromatopsia (HP:0007641)2.04286377
62Pancreatic fibrosis (HP:0100732)2.03865044
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.00624469
64Glioma (HP:0009733)1.97340230
65Methylmalonic acidemia (HP:0002912)1.95899117
66Patent foramen ovale (HP:0001655)1.94954943
67Aplasia/hypoplasia of the humerus (HP:0006507)1.94556011
68Bony spicule pigmentary retinopathy (HP:0007737)1.94382065
69Ureteral duplication (HP:0000073)1.93356909
70Neoplasm of the oral cavity (HP:0100649)1.92588893
71True hermaphroditism (HP:0010459)1.91560029
72Abnormality of the parathyroid morphology (HP:0011766)1.91254435
733-Methylglutaconic aciduria (HP:0003535)1.89984082
74Small hand (HP:0200055)1.89475697
75Hyperglycemia (HP:0003074)1.89458651
76Polydipsia (HP:0001959)1.88183312
77Abnormal drinking behavior (HP:0030082)1.88183312
78Absent hand (HP:0004050)1.87817487
79Infantile muscular hypotonia (HP:0008947)1.84254053
80Chromsome breakage (HP:0040012)1.84090610
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.83915642
82Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.83872543
83Supernumerary spleens (HP:0009799)1.83696951
84Abnormality of the nasal septum (HP:0000419)1.83244727
85Aplasia/Hypoplasia of the hallux (HP:0008362)1.80898567
86Optic nerve hypoplasia (HP:0000609)1.79897800
87Anophthalmia (HP:0000528)1.79265210
88Colon cancer (HP:0003003)1.77490542
89Depressed nasal tip (HP:0000437)1.76965145
90Renal agenesis (HP:0000104)1.76591122
91Congenital, generalized hypertrichosis (HP:0004540)1.76056492
92Large for gestational age (HP:0001520)1.74168086
93Adactyly (HP:0009776)1.73603004
94Hydroxyprolinuria (HP:0003080)1.72676209
95Abnormality of proline metabolism (HP:0010907)1.72676209
96Midline defect of the nose (HP:0004122)1.72338904
97Horizontal nystagmus (HP:0000666)1.71509620
98Ependymoma (HP:0002888)1.71121465
99Medulloblastoma (HP:0002885)1.69589832
100Abnormality of the labia minora (HP:0012880)1.68351213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB45.09721693
2ACVR1B4.04722388
3BMPR1B3.99099475
4TRIM283.84843857
5EIF2AK13.66618639
6PLK43.65585262
7PRKD33.49167098
8PBK3.18790951
9WNK33.16017391
10NUAK12.66173644
11MKNK22.13639208
12FRK1.99382277
13SIK31.93250837
14EIF2AK31.92984109
15MST41.88124195
16TNK21.86760951
17MAP4K21.81941158
18STK161.70612331
19TNIK1.64722386
20PLK21.52413603
21FLT31.46007299
22PKN21.44745920
23WEE11.42577315
24STK101.37540361
25ARAF1.31538628
26GRK11.18226206
27NME11.14618806
28BRAF1.11180512
29IRAK11.09934232
30MAP3K121.06922375
31MAPK131.04929397
32STK391.02401383
33TGFBR11.02103484
34WNK40.98318116
35PNCK0.98147374
36MKNK10.90282618
37ADRBK20.89525880
38ERBB30.89304736
39MAP3K40.88116566
40STK38L0.84494422
41MUSK0.84439080
42BUB10.84389238
43BRSK20.83673875
44EIF2AK20.79810282
45RAF10.78895396
46PLK30.77896295
47PRKD20.77247103
48SRPK10.76171382
49OXSR10.75583035
50ADRBK10.74204738
51ZAK0.70914684
52IRAK20.69805292
53PRKCE0.69059779
54FER0.66704926
55STK30.66360426
56VRK10.63495364
57CASK0.63334300
58MAP3K90.61798874
59TTK0.61711932
60TAF10.60583794
61TEC0.59759662
62PIK3CG0.56412928
63BRD40.56025319
64PLK10.54519185
65MAPKAPK30.53432220
66BCKDK0.52550321
67DMPK0.49440170
68PRKCQ0.48995763
69NLK0.45994841
70EPHA20.44904523
71NTRK30.44455805
72PRKCH0.43778279
73BCR0.42702002
74PRKCG0.41456820
75CAMK2A0.41084012
76PRKG10.40110043
77PINK10.39322956
78MELK0.34904106
79ATM0.34154371
80DAPK20.32608832
81MAP3K80.31697105
82KSR10.30816013
83PTK2B0.30194052
84MAP3K30.29706272
85VRK20.29098044
86CDC70.28536904
87CSNK1G10.28492553
88PRKDC0.28237145
89CAMK2D0.27108632
90EPHA40.25459747
91MAP3K130.23332454
92LATS10.21908715
93PRKACB0.21388151
94ROCK20.20739321
95TSSK60.19927037
96CSNK1G20.19161972
97PRKG20.18294966
98MAP2K10.17726751
99MOS0.17670839
100ALK0.17500525

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.17667334
2Non-homologous end-joining_Homo sapiens_hsa034503.08591548
3Butanoate metabolism_Homo sapiens_hsa006502.91423082
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.79865196
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79061883
6Protein export_Homo sapiens_hsa030602.73985286
7Steroid biosynthesis_Homo sapiens_hsa001002.56416346
8Fatty acid metabolism_Homo sapiens_hsa012122.46856375
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35909046
10Propanoate metabolism_Homo sapiens_hsa006402.29665616
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23844049
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23608633
13Fatty acid elongation_Homo sapiens_hsa000622.21351266
14Homologous recombination_Homo sapiens_hsa034402.21127635
15One carbon pool by folate_Homo sapiens_hsa006702.05013851
16Caffeine metabolism_Homo sapiens_hsa002321.98242027
17RNA degradation_Homo sapiens_hsa030181.95728667
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92508240
19Mismatch repair_Homo sapiens_hsa034301.84024933
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82437846
21Fatty acid biosynthesis_Homo sapiens_hsa000611.81730393
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76802709
23Fatty acid degradation_Homo sapiens_hsa000711.75279163
24Fanconi anemia pathway_Homo sapiens_hsa034601.73543383
25Phototransduction_Homo sapiens_hsa047441.51623158
26Vitamin B6 metabolism_Homo sapiens_hsa007501.50312468
27Peroxisome_Homo sapiens_hsa041461.49482830
28Basal transcription factors_Homo sapiens_hsa030221.49455341
29Proteasome_Homo sapiens_hsa030501.48908873
30Selenocompound metabolism_Homo sapiens_hsa004501.48073175
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.44217427
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43434511
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42430970
34Sulfur metabolism_Homo sapiens_hsa009201.37120837
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35941101
36Basal cell carcinoma_Homo sapiens_hsa052171.29545636
37Tryptophan metabolism_Homo sapiens_hsa003801.24449702
38Pyruvate metabolism_Homo sapiens_hsa006201.22229983
39Circadian entrainment_Homo sapiens_hsa047131.20448417
40Hedgehog signaling pathway_Homo sapiens_hsa043401.17082224
41Wnt signaling pathway_Homo sapiens_hsa043101.14630126
42Vitamin digestion and absorption_Homo sapiens_hsa049771.13770681
43RNA polymerase_Homo sapiens_hsa030201.09329440
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07446101
45Retinol metabolism_Homo sapiens_hsa008300.99379613
46* Olfactory transduction_Homo sapiens_hsa047400.95950229
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92381373
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90227391
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87354399
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87331422
51Hippo signaling pathway_Homo sapiens_hsa043900.86848182
52PPAR signaling pathway_Homo sapiens_hsa033200.85935214
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82229349
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79588545
55N-Glycan biosynthesis_Homo sapiens_hsa005100.75153823
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74468638
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71953032
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70867637
59Cell cycle_Homo sapiens_hsa041100.70589833
60Oocyte meiosis_Homo sapiens_hsa041140.69177077
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.68799102
62Linoleic acid metabolism_Homo sapiens_hsa005910.68274445
63RNA transport_Homo sapiens_hsa030130.67124866
64Nucleotide excision repair_Homo sapiens_hsa034200.66252297
65Glutathione metabolism_Homo sapiens_hsa004800.62630047
66Metabolic pathways_Homo sapiens_hsa011000.61001866
67DNA replication_Homo sapiens_hsa030300.59765447
68Circadian rhythm_Homo sapiens_hsa047100.59508546
69ABC transporters_Homo sapiens_hsa020100.57672060
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56702571
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53225996
72TGF-beta signaling pathway_Homo sapiens_hsa043500.49120123
73Nicotine addiction_Homo sapiens_hsa050330.48058410
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45473295
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45070545
76Inositol phosphate metabolism_Homo sapiens_hsa005620.44585914
77Chemical carcinogenesis_Homo sapiens_hsa052040.44481617
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43542485
79p53 signaling pathway_Homo sapiens_hsa041150.42747582
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.41060996
81Purine metabolism_Homo sapiens_hsa002300.39090101
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38498391
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37330832
84Fat digestion and absorption_Homo sapiens_hsa049750.36665776
85Protein digestion and absorption_Homo sapiens_hsa049740.35693569
86mRNA surveillance pathway_Homo sapiens_hsa030150.35307278
87Calcium signaling pathway_Homo sapiens_hsa040200.34580547
88Serotonergic synapse_Homo sapiens_hsa047260.32464238
89Nitrogen metabolism_Homo sapiens_hsa009100.32103821
90Gastric acid secretion_Homo sapiens_hsa049710.29878295
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28470394
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.27956815
93Melanoma_Homo sapiens_hsa052180.26421230
94Glucagon signaling pathway_Homo sapiens_hsa049220.24115309
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21633397
96Lysine degradation_Homo sapiens_hsa003100.21552972
97Folate biosynthesis_Homo sapiens_hsa007900.21111595
98Glutamatergic synapse_Homo sapiens_hsa047240.20950292
99Insulin secretion_Homo sapiens_hsa049110.19705189
100GABAergic synapse_Homo sapiens_hsa047270.19417593

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