ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.50149973
2	male meiosis I (GO:0007141)	9.45418042
3	piRNA metabolic process (GO:0034587)	8.35045730
4	meiosis I (GO:0007127)	7.50097465
5	meiotic nuclear division (GO:0007126)	7.17368615
6	DNA methylation involved in gamete generation (GO:0043046)	7.17082193
7	meiotic cell cycle process (GO:1903046)	6.42883886
8	resolution of meiotic recombination intermediates (GO:0000712)	6.03026641
9	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.35596310
10	sister chromatid cohesion (GO:0007062)	4.85041853
11	positive regulation of catecholamine secretion (GO:0033605)	4.72073990
12	histone H3-K36 demethylation (GO:0070544)	4.68089275
13	reciprocal meiotic recombination (GO:0007131)	4.64332110
14	reciprocal DNA recombination (GO:0035825)	4.64332110
15	potassium ion export (GO:0071435)	4.60083278
16	gene silencing by RNA (GO:0031047)	4.56075894
17	regulation of oxidative stress-induced neuron death (GO:1903203)	4.49545137
18	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	4.38053852
19	motile cilium assembly (GO:0044458)	4.29949723
20	membrane repolarization during action potential (GO:0086011)	4.26046636
21	mRNA cleavage (GO:0006379)	4.25617873
22	binding of sperm to zona pellucida (GO:0007339)	4.23113090
23	coenzyme catabolic process (GO:0009109)	4.14514931
24	activation of protein kinase B activity (GO:0032148)	4.09046413
25	regulation of autophagic vacuole assembly (GO:2000785)	4.07687128
26	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.07026065
27	positive regulation of cell cycle G1/S phase transition (GO:1902808)	4.00278102
28	regulation of meiosis I (GO:0060631)	3.79761448
29	meiotic chromosome segregation (GO:0045132)	3.75259609
30	acrosome assembly (GO:0001675)	3.56043813
31	histone exchange (GO:0043486)	3.51017521
32	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.47112582
33	DNA double-strand break processing (GO:0000729)	3.45793818
34	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.44473687
35	spermatid nucleus differentiation (GO:0007289)	3.42279477
36	histone H3-K9 demethylation (GO:0033169)	3.41541536
37	membrane repolarization (GO:0086009)	3.33587070
38	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.32900814
39	regulation of vacuole organization (GO:0044088)	3.27112365
40	ADP metabolic process (GO:0046031)	3.20981952
41	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.19087254
42	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.15562407
43	spermatid development (GO:0007286)	3.13651588
44	chromosome organization (GO:0051276)	3.12314565
45	fertilization (GO:0009566)	3.11986870
46	sperm-egg recognition (GO:0035036)	3.10693554
47	dicarboxylic acid catabolic process (GO:0043649)	3.08732683
48	positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)	3.05765519
49	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.03090089
50	TOR signaling (GO:0031929)	3.01525138
51	DNA biosynthetic process (GO:0071897)	2.97877277
52	response to misfolded protein (GO:0051788)	2.97623840
53	regulation of translational fidelity (GO:0006450)	2.96641458
54	androgen biosynthetic process (GO:0006702)	2.95117837
55	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.91817252
56	epithelial cilium movement (GO:0003351)	2.83223128
57	gene silencing (GO:0016458)	2.82389278
58	glutamine family amino acid catabolic process (GO:0009065)	2.79149312
59	relaxation of smooth muscle (GO:0044557)	2.75763952
60	cell-cell recognition (GO:0009988)	2.75737985
61	tRNA methylation (GO:0030488)	2.74878683
62	regulation of oxidative phosphorylation (GO:0002082)	2.74457500
63	mitochondrion degradation (GO:0000422)	2.72939709
64	nuclear pore complex assembly (GO:0051292)	2.70627117
65	oligosaccharide biosynthetic process (GO:0009312)	2.70393372
66	multicellular organism reproduction (GO:0032504)	2.68722376
67	proteasome assembly (GO:0043248)	2.67402523
68	diterpenoid biosynthetic process (GO:0016102)	2.65827495
69	meiotic cell cycle (GO:0051321)	2.65020711
70	regulation of membrane repolarization (GO:0060306)	2.65020692
71	axonemal dynein complex assembly (GO:0070286)	2.63230471
72	female gamete generation (GO:0007292)	2.62286417
73	diacylglycerol metabolic process (GO:0046339)	2.60880044
74	sex differentiation (GO:0007548)	2.60863063
75	DNA replication initiation (GO:0006270)	2.60693086
76	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.60287388
77	potassium ion import (GO:0010107)	2.58408480
78	ventricular system development (GO:0021591)	2.58305307
79	peroxisome fission (GO:0016559)	2.56731726
80	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.56627372
81	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.56604841
82	sperm motility (GO:0030317)	2.55436746
83	regulation of meiotic cell cycle (GO:0051445)	2.52919488
84	regulation of phospholipase A2 activity (GO:0032429)	2.51909419
85	DNA alkylation (GO:0006305)	2.49713470
86	DNA methylation (GO:0006306)	2.49713470
87	oogenesis (GO:0048477)	2.49250393
88	DNA packaging (GO:0006323)	2.47796997
89	forebrain morphogenesis (GO:0048853)	2.47497578
90	nucleoside diphosphate biosynthetic process (GO:0009133)	2.47382532
91	regulation of synapse maturation (GO:0090128)	2.43931662
92	regulation of coenzyme metabolic process (GO:0051196)	2.42660769
93	regulation of cofactor metabolic process (GO:0051193)	2.42660769
94	centriole assembly (GO:0098534)	2.42357171
95	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.40490907
96	synapsis (GO:0007129)	15.0261872
97	chromosome organization involved in meiosis (GO:0070192)	12.9497300
98	synaptonemal complex assembly (GO:0007130)	12.3557750
99	DNA synthesis involved in DNA repair (GO:0000731)	11.5484879
100	synaptonemal complex organization (GO:0070193)	10.9810058

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.93328182
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.67633598
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.91296566
4	EZH2_22144423_ChIP-Seq_EOC_Human	4.84758776
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.65653015
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.67569621
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.26556286
8	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.89646791
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.79201376
10	GATA1_22025678_ChIP-Seq_K562_Human	2.62420125
11	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.46513710
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.44531789
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.43668036
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.40597897
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.34249399
16	DCP1A_22483619_ChIP-Seq_HELA_Human	2.16830098
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04832192
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98366713
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.97893832
20	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.95044401
21	VDR_22108803_ChIP-Seq_LS180_Human	1.91189766
22	ERA_21632823_ChIP-Seq_H3396_Human	1.85643153
23	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.75869619
24	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.66404144
25	E2F7_22180533_ChIP-Seq_HELA_Human	1.50489488
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.49459505
27	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.48940014
28	FUS_26573619_Chip-Seq_HEK293_Human	1.45950741
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.43689864
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.42321801
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38751716
32	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.38563287
33	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.38067318
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.36932950
35	RAC3_21632823_ChIP-Seq_H3396_Human	1.34386916
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.34353837
37	KDM5A_27292631_Chip-Seq_BREAST_Human	1.33570196
38	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.32297286
39	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.28411197
40	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28010190
41	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.22364703
42	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.21636017
43	SMC4_20622854_ChIP-Seq_HELA_Human	1.19051084
44	SPI1_20517297_ChIP-Seq_HL60_Human	1.18421626
45	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.15452357
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.14250848
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14223901
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.14223901
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13396339
50	TBL1_22424771_ChIP-Seq_293T_Human	1.12003168
51	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.11348171
52	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10931166
53	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.10186503
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09930082
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09930082
56	PHF8_20622853_ChIP-Seq_HELA_Human	1.08215127
57	OCT4_20526341_ChIP-Seq_ESCs_Human	1.08141674
58	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06874007
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05754801
60	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.03686640
61	CHD1_26751641_Chip-Seq_LNCaP_Human	1.01858088
62	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.99815875
63	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97879411
64	XRN2_22483619_ChIP-Seq_HELA_Human	0.97794729
65	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97632115
66	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.94787530
67	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.94689170
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92384175
69	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92330054
70	RUNX2_22187159_ChIP-Seq_PCA_Human	0.90947811
71	MYC_19829295_ChIP-Seq_ESCs_Human	0.90774882
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90485244
73	PHF8_20622854_ChIP-Seq_HELA_Human	0.90453352
74	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.90408233
75	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.90305125
76	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89577540
77	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.88494900
78	ETV1_20927104_ChIP-Seq_GIST48_Human	0.87831465
79	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.86269762
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85008491
81	NFYB_21822215_ChIP-Seq_K562_Human	0.84097544
82	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.83041577
83	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.82952703
84	RXR_22108803_ChIP-Seq_LS180_Human	0.81963949
85	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.80724360
86	ZNF263_19887448_ChIP-Seq_K562_Human	0.80141209
87	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.79437893
88	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.78933152
89	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.78702060
90	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.78075073
91	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.77630823
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.77423510
93	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.77399127
94	AR_21909140_ChIP-Seq_LNCAP_Human	0.76162984
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.75730102
96	OCT4_19829295_ChIP-Seq_ESCs_Human	0.75047179
97	STAT1_17558387_ChIP-Seq_HELA_Human	0.74824618
98	CTCF_21964334_Chip-Seq_Bcells_Human	0.74494314
99	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.73873116
100	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.73644439

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008004_abnormal_stomach_pH	4.37490021
2	MP0008877_abnormal_DNA_methylation	4.14614590
3	MP0002160_abnormal_reproductive_system	4.13280097
4	MP0008058_abnormal_DNA_repair	3.58452439
5	MP0001929_abnormal_gametogenesis	3.38119135
6	MP0002210_abnormal_sex_determination	3.34728187
7	MP0003698_abnormal_male_reproductive	3.02447253
8	MP0005410_abnormal_fertilization	2.74307901
9	MP0000749_muscle_degeneration	2.72368733
10	MP0001145_abnormal_male_reproductive	2.67511305
11	MP0005360_urolithiasis	2.43177224
12	MP0000653_abnormal_sex_gland	2.37805447
13	MP0002132_abnormal_respiratory_system	2.27602970
14	MP0001984_abnormal_olfaction	2.24028039
15	MP0004084_abnormal_cardiac_muscle	2.16481910
16	MP0003315_abnormal_perineum_morphology	2.15905077
17	MP0009697_abnormal_copulation	2.12572674
18	MP0003136_yellow_coat_color	2.12290492
19	MP0005499_abnormal_olfactory_system	2.02206943
20	MP0005394_taste/olfaction_phenotype	2.02206943
21	MP0000678_abnormal_parathyroid_gland	1.90344071
22	MP0005389_reproductive_system_phenotype	1.87844557
23	MP0002161_abnormal_fertility/fecundity	1.79514124
24	MP0000537_abnormal_urethra_morphology	1.78895042
25	MP0008995_early_reproductive_senescence	1.78856397
26	MP0004036_abnormal_muscle_relaxation	1.75218286
27	MP0005187_abnormal_penis_morphology	1.74533402
28	MP0003385_abnormal_body_wall	1.74169975
29	MP0010368_abnormal_lymphatic_system	1.63639618
30	MP0006036_abnormal_mitochondrial_physio	1.62900815
31	MP0004272_abnormal_basement_membrane	1.58936060
32	MP0003699_abnormal_female_reproductive	1.55914590
33	MP0002269_muscular_atrophy	1.52664723
34	MP0009780_abnormal_chondrocyte_physiolo	1.49143052
35	MP0004859_abnormal_synaptic_plasticity	1.45570818
36	MP0001661_extended_life_span	1.44187186
37	MP0003806_abnormal_nucleotide_metabolis	1.42273205
38	MP0005330_cardiomyopathy	1.41716408
39	MP0008007_abnormal_cellular_replicative	1.40512868
40	MP0006035_abnormal_mitochondrial_morpho	1.40512753
41	MP0010094_abnormal_chromosome_stability	1.36704424
42	MP0004215_abnormal_myocardial_fiber	1.36390905
43	MP0003938_abnormal_ear_development	1.34094706
44	MP0003879_abnormal_hair_cell	1.32491755
45	MP0005423_abnormal_somatic_nervous	1.31537642
46	MP0005058_abnormal_lysosome_morphology	1.29727027
47	MP0002249_abnormal_larynx_morphology	1.24825883
48	MP0001664_abnormal_digestion	1.23141636
49	MP0001119_abnormal_female_reproductive	1.22756066
50	MP0001502_abnormal_circadian_rhythm	1.18000255
51	MP0002108_abnormal_muscle_morphology	1.17561865
52	MP0009046_muscle_twitch	1.17234828
53	MP0003656_abnormal_erythrocyte_physiolo	1.15868211
54	MP0001270_distended_abdomen	1.14638984
55	MP0005646_abnormal_pituitary_gland	1.14503429
56	MP0001188_hyperpigmentation	1.09202653
57	MP0002837_dystrophic_cardiac_calcinosis	1.08984191
58	MP0008789_abnormal_olfactory_epithelium	1.08244326
59	MP0004510_myositis	0.99579835
60	MP0000747_muscle_weakness	0.97121961
61	MP0000049_abnormal_middle_ear	0.96733724
62	MP0008932_abnormal_embryonic_tissue	0.96642018
63	MP0004811_abnormal_neuron_physiology	0.96128310
64	MP0003635_abnormal_synaptic_transmissio	0.93043220
65	MP0001529_abnormal_vocalization	0.92957142
66	MP0000566_synostosis	0.91479659
67	MP0003693_abnormal_embryo_hatching	0.90609072
68	MP0005409_darkened_coat_color	0.89437409
69	MP0002127_abnormal_cardiovascular_syste	0.86319680
70	MP0004197_abnormal_fetal_growth/weight/	0.86188500
71	MP0004233_abnormal_muscle_weight	0.86149738
72	MP0003786_premature_aging	0.85087230
73	MP0001299_abnormal_eye_distance/	0.83098105
74	MP0001986_abnormal_taste_sensitivity	0.82123732
75	MP0009250_abnormal_appendicular_skeleto	0.80752676
76	MP0002090_abnormal_vision	0.79838856
77	MP0008775_abnormal_heart_ventricle	0.79496534
78	MP0001485_abnormal_pinna_reflex	0.79160751
79	MP0004087_abnormal_muscle_fiber	0.78771763
80	MP0003632_abnormal_nervous_system	0.77706998
81	MP0003077_abnormal_cell_cycle	0.75500203
82	MP0003935_abnormal_craniofacial_develop	0.75269316
83	MP0003111_abnormal_nucleus_morphology	0.74655696
84	MP0005620_abnormal_muscle_contractility	0.71902638
85	MP0005647_abnormal_sex_gland	0.71884084
86	MP0010386_abnormal_urinary_bladder	0.69922406
87	MP0005248_abnormal_Harderian_gland	0.68866302
88	MP0004085_abnormal_heartbeat	0.68551360
89	MP0000681_abnormal_thyroid_gland	0.68501222
90	MP0003631_nervous_system_phenotype	0.67912589
91	MP0010234_abnormal_vibrissa_follicle	0.66112898
92	MP0000462_abnormal_digestive_system	0.64153128
93	MP0001849_ear_inflammation	0.64107493
94	MP0003329_amyloid_beta_deposits	0.63534759
95	MP0009840_abnormal_foam_cell	0.62101764
96	MP0010630_abnormal_cardiac_muscle	0.59876951
97	MP0000759_abnormal_skeletal_muscle	0.59684861
98	MP0002272_abnormal_nervous_system	0.59161679
99	MP0002063_abnormal_learning/memory/cond	0.57902064
100	MP0002233_abnormal_nose_morphology	0.57418084

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Upper limb muscle weakness (HP:0003484)	4.60983851
2	Ventricular fibrillation (HP:0001663)	4.36162420
3	Azoospermia (HP:0000027)	4.11835610
4	Urinary urgency (HP:0000012)	4.05087940
5	Abnormality of the columella (HP:0009929)	4.02441851
6	Resting tremor (HP:0002322)	3.90836331
7	Recurrent corneal erosions (HP:0000495)	3.89034589
8	Spontaneous abortion (HP:0005268)	3.88736070
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.81295361
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.81295361
11	Abnormality of cochlea (HP:0000375)	3.77860483
12	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.35288154
13	Rimmed vacuoles (HP:0003805)	3.27265681
14	Retinal dysplasia (HP:0007973)	3.24010169
15	Morphological abnormality of the inner ear (HP:0011390)	3.16724319
16	Abnormal ciliary motility (HP:0012262)	3.14769611
17	Gonadotropin excess (HP:0000837)	3.07806496
18	Facial hemangioma (HP:0000329)	3.04233541
19	Abnormality of the shoulder girdle musculature (HP:0001435)	3.04222846
20	Postural instability (HP:0002172)	3.03026106
21	Long foot (HP:0001833)	2.90729637
22	Abnormal respiratory motile cilium physiology (HP:0012261)	2.83032540
23	Scapular winging (HP:0003691)	2.79673173
24	Cholecystitis (HP:0001082)	2.78420882
25	Abnormal gallbladder physiology (HP:0012438)	2.78420882
26	Absent/shortened dynein arms (HP:0200106)	2.73633892
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73633892
28	Cortical dysplasia (HP:0002539)	2.72474084
29	Reticulocytosis (HP:0001923)	2.67405881
30	Abnormal spermatogenesis (HP:0008669)	2.57896473
31	Bowel incontinence (HP:0002607)	2.54262323
32	Spinal rigidity (HP:0003306)	2.53041172
33	Hyporeflexia of lower limbs (HP:0002600)	2.49781279
34	Truncus arteriosus (HP:0001660)	2.43965789
35	Reduced antithrombin III activity (HP:0001976)	2.41949163
36	Abnormal large intestine physiology (HP:0012700)	2.40919345
37	Atonic seizures (HP:0010819)	2.39898373
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.39144511
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.39144511
40	Unilateral renal agenesis (HP:0000122)	2.38716905
41	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.35168692
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.33780564
43	Abnormality of the calf musculature (HP:0001430)	2.33268584
44	Proximal amyotrophy (HP:0007126)	2.33258226
45	Clumsiness (HP:0002312)	2.24273290
46	Large hands (HP:0001176)	2.23415541
47	Capillary hemangiomas (HP:0005306)	2.22600972
48	Tubulointerstitial nephritis (HP:0001970)	2.22034508
49	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.21968090
50	Self-mutilation (HP:0000742)	2.21283472
51	Chromsome breakage (HP:0040012)	2.18942734
52	High anterior hairline (HP:0009890)	2.18842609
53	Median cleft lip (HP:0000161)	2.17615151
54	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.17245260
55	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.12924605
56	Infertility (HP:0000789)	2.07858764
57	Exercise-induced muscle cramps (HP:0003710)	2.06184222
58	Sensory axonal neuropathy (HP:0003390)	2.05606065
59	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.05460494
60	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.05460494
61	Decreased lacrimation (HP:0000633)	2.02046938
62	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99341231
63	Alacrima (HP:0000522)	1.97872426
64	Duplication of thumb phalanx (HP:0009942)	1.97807985
65	Duplicated collecting system (HP:0000081)	1.97757905
66	Hypoplasia of the uterus (HP:0000013)	1.95855837
67	Thoracic kyphosis (HP:0002942)	1.95441558
68	Ankyloglossia (HP:0010296)	1.94789555
69	Bifid scrotum (HP:0000048)	1.93410900
70	Ragged-red muscle fibers (HP:0003200)	1.93409343
71	EMG: myopathic abnormalities (HP:0003458)	1.92634746
72	Absent eyebrow (HP:0002223)	1.92324707
73	Hand muscle atrophy (HP:0009130)	1.92130667
74	Renal dysplasia (HP:0000110)	1.91059372
75	Impaired vibration sensation in the lower limbs (HP:0002166)	1.90267061
76	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.86410550
77	Hyperthyroidism (HP:0000836)	1.85948378
78	Cortical visual impairment (HP:0100704)	1.84270171
79	Neoplasm of the oral cavity (HP:0100649)	1.82231515
80	Abnormality of the frontal sinuses (HP:0002687)	1.81547270
81	Abnormality of reticulocytes (HP:0004312)	1.79491951
82	Abnormality of the renal collecting system (HP:0004742)	1.79342926
83	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.73617536
84	Benign neoplasm of the central nervous system (HP:0100835)	1.73312388
85	Thin ribs (HP:0000883)	1.73250858
86	Hypoparathyroidism (HP:0000829)	1.72980197
87	Syncope (HP:0001279)	1.72593874
88	Exercise-induced myalgia (HP:0003738)	1.71548801
89	Abnormality of the dental root (HP:0006486)	1.68206718
90	Taurodontia (HP:0000679)	1.68206718
91	Abnormality of permanent molar morphology (HP:0011071)	1.68206718
92	Unsteady gait (HP:0002317)	1.67804067
93	Prolonged QT interval (HP:0001657)	1.67504008
94	Abnormality of the ileum (HP:0001549)	1.66317223
95	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.64634417
96	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.63513908
97	Abnormality of the intrinsic pathway (HP:0010989)	1.62585137
98	Gonadal dysgenesis (HP:0000133)	1.59723093
99	Spastic gait (HP:0002064)	1.57034001
100	Limb ataxia (HP:0002070)	1.56509390

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.35282447
2	MARK3	4.09623687
3	NEK2	3.55828205
4	LATS1	3.43496183
5	PDK2	2.77140744
6	KSR2	2.56173388
7	MYLK	2.52440611
8	OBSCN	2.29986860
9	LATS2	2.08208564
10	STK38L	1.93551272
11	MAP3K2	1.87197206
12	MAP2K7	1.84109200
13	EEF2K	1.78596950
14	SRPK1	1.78125724
15	KSR1	1.70104633
16	CDK3	1.68711531
17	RAF1	1.56524326
18	RPS6KA4	1.56415860
19	STK38	1.53270390
20	CDK19	1.50288651
21	ZAK	1.49517851
22	EIF2AK3	1.40236672
23	BRD4	1.37525654
24	RPS6KB1	1.33176404
25	NTRK3	1.26925322
26	TLK1	1.24522944
27	CCNB1	1.23262405
28	RET	1.17422338
29	ICK	1.17306096
30	TTK	1.16171796
31	FGFR2	1.15504154
32	SGK494	1.13834078
33	SGK223	1.13834078
34	RPS6KA5	1.06823986
35	DYRK3	1.01354658
36	FRK	0.99313979
37	MINK1	0.96273919
38	ARAF	0.93321790
39	BMPR1B	0.91693270
40	MAP3K1	0.90621719
41	PLK1	0.88667578
42	PRKG2	0.87839849
43	INSRR	0.83284748
44	EPHA3	0.82638216
45	CDK12	0.82404110
46	CSNK1A1L	0.81356268
47	CLK1	0.80818511
48	PAK1	0.79195239
49	NME2	0.76636241
50	CDK14	0.75828919
51	MOS	0.75626154
52	MAPK12	0.74987179
53	EIF2AK1	0.74379153
54	PLK2	0.73847950
55	MAP3K13	0.73607743
56	PLK4	0.71446942
57	PDPK1	0.65653452
58	MAPK15	0.65480310
59	PKN2	0.65453124
60	NEK9	0.61587606
61	GRK5	0.61385132
62	ATM	0.60917230
63	MAP3K9	0.60500416
64	MAP3K5	0.59360951
65	AKT2	0.58355093
66	PAK6	0.56679302
67	MAP3K4	0.56019939
68	CSNK1G3	0.54765089
69	DAPK3	0.52645586
70	PTK2B	0.51848498
71	NEK1	0.50795601
72	MAP3K10	0.50208932
73	ROCK1	0.49709430
74	SGK2	0.47410427
75	PAK2	0.47236062
76	WEE1	0.46042944
77	BCR	0.45620709
78	MELK	0.42910443
79	EGFR	0.42795493
80	MARK1	0.39980957
81	MTOR	0.37741985
82	CHEK1	0.37082339
83	TRIM28	0.35685249
84	RPS6KA1	0.35381351
85	TIE1	0.34880471
86	PHKG2	0.34649680
87	PHKG1	0.34649680
88	FGR	0.34125737
89	FGFR3	0.33002847
90	PDK1	0.32699588
91	ATR	0.32209889
92	MAPKAPK3	0.32135746
93	AURKB	0.31548580
94	BRAF	0.31315937
95	IRAK2	0.30953295
96	TRIB3	0.30306482
97	JAK2	0.28545382
98	CDK5	0.28106190
99	PRKCQ	0.25004623
100	CAMK2B	0.24893395

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.16109978
2	Olfactory transduction_Homo sapiens_hsa04740	3.02480505
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.77271357
4	Butanoate metabolism_Homo sapiens_hsa00650	2.68800587
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.47911643
6	Oocyte meiosis_Homo sapiens_hsa04114	2.47180211
7	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.41965906
8	Gap junction_Homo sapiens_hsa04540	2.36995874
9	Pyruvate metabolism_Homo sapiens_hsa00620	2.29801865
10	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.28407535
11	Homologous recombination_Homo sapiens_hsa03440	2.27066971
12	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.23040885
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.22922789
14	Propanoate metabolism_Homo sapiens_hsa00640	2.06941647
15	mRNA surveillance pathway_Homo sapiens_hsa03015	2.01163073
16	DNA replication_Homo sapiens_hsa03030	1.81332442
17	Circadian rhythm_Homo sapiens_hsa04710	1.75014487
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.71148136
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62873530
20	beta-Alanine metabolism_Homo sapiens_hsa00410	1.56383918
21	RNA transport_Homo sapiens_hsa03013	1.55765207
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.52105425
23	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.44883157
24	Basal transcription factors_Homo sapiens_hsa03022	1.38651286
25	Taste transduction_Homo sapiens_hsa04742	1.35492842
26	Mismatch repair_Homo sapiens_hsa03430	1.34092359
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.31334189
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.24773223
29	mTOR signaling pathway_Homo sapiens_hsa04150	1.19308913
30	Cell cycle_Homo sapiens_hsa04110	1.17137325
31	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.16051118
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14993598
33	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.14785251
34	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.12294836
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11541629
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.07871493
37	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.05123629
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.03713831
39	Endometrial cancer_Homo sapiens_hsa05213	1.02297577
40	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.99276862
41	Glucagon signaling pathway_Homo sapiens_hsa04922	0.97618095
42	AMPK signaling pathway_Homo sapiens_hsa04152	0.97607056
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.97602142
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.97567335
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96079958
46	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.94821738
47	GABAergic synapse_Homo sapiens_hsa04727	0.93365545
48	Apoptosis_Homo sapiens_hsa04210	0.92868198
49	Circadian entrainment_Homo sapiens_hsa04713	0.88663039
50	RNA degradation_Homo sapiens_hsa03018	0.84973609
51	Nicotine addiction_Homo sapiens_hsa05033	0.84683193
52	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.82603877
53	Purine metabolism_Homo sapiens_hsa00230	0.82471698
54	Long-term potentiation_Homo sapiens_hsa04720	0.81523887
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.80795368
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.80705026
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.80296551
58	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.80146933
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.77132751
60	Type II diabetes mellitus_Homo sapiens_hsa04930	0.71676633
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71169519
62	Alcoholism_Homo sapiens_hsa05034	0.70109726
63	Carbon metabolism_Homo sapiens_hsa01200	0.66911919
64	Phagosome_Homo sapiens_hsa04145	0.61736635
65	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.60815995
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60783312
67	Gastric acid secretion_Homo sapiens_hsa04971	0.60419035
68	Melanoma_Homo sapiens_hsa05218	0.56259253
69	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56118712
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54983582
71	Spliceosome_Homo sapiens_hsa03040	0.54668586
72	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.53124527
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.52687980
74	Insulin signaling pathway_Homo sapiens_hsa04910	0.51014166
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50055545
76	Retinol metabolism_Homo sapiens_hsa00830	0.49064177
77	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.48987281
78	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.48528896
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.45005446
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44612389
81	Prostate cancer_Homo sapiens_hsa05215	0.44548777
82	Sulfur relay system_Homo sapiens_hsa04122	0.43371031
83	Choline metabolism in cancer_Homo sapiens_hsa05231	0.41775765
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41152836
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41076892
86	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.40526644
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40416405
88	Renin secretion_Homo sapiens_hsa04924	0.40200250
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.39639184
90	Pentose phosphate pathway_Homo sapiens_hsa00030	0.39471273
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38389508
92	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.37560940
93	Long-term depression_Homo sapiens_hsa04730	0.37349740
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37149722
95	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.36349250
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32886154
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32313332
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.31534947
99	Glutathione metabolism_Homo sapiens_hsa00480	0.31436884
100	ABC transporters_Homo sapiens_hsa02010	0.31361691

OR6E1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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