ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.80297107
2	water-soluble vitamin biosynthetic process (GO:0042364)	5.33897174
3	respiratory chain complex IV assembly (GO:0008535)	4.80283110
4	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.30339098
5	cullin deneddylation (GO:0010388)	4.29108618
6	cytochrome complex assembly (GO:0017004)	4.03612037
7	peptidyl-histidine modification (GO:0018202)	3.90922422
8	L-methionine salvage (GO:0071267)	3.88707698
9	L-methionine biosynthetic process (GO:0071265)	3.88707698
10	amino acid salvage (GO:0043102)	3.88707698
11	regulation of cilium movement (GO:0003352)	3.79219036
12	protein deneddylation (GO:0000338)	3.77682568
13	L-fucose catabolic process (GO:0042355)	3.65414030
14	fucose catabolic process (GO:0019317)	3.65414030
15	L-fucose metabolic process (GO:0042354)	3.65414030
16	indolalkylamine metabolic process (GO:0006586)	3.63291361
17	protein-cofactor linkage (GO:0018065)	3.60733548
18	behavioral response to nicotine (GO:0035095)	3.59490931
19	aldehyde catabolic process (GO:0046185)	3.58170126
20	response to pheromone (GO:0019236)	3.46196141
21	pseudouridine synthesis (GO:0001522)	3.43483063
22	kynurenine metabolic process (GO:0070189)	3.42436099
23	protein complex biogenesis (GO:0070271)	3.39922394
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.38605639
25	tryptophan metabolic process (GO:0006568)	3.37400695
26	chaperone-mediated protein transport (GO:0072321)	3.37168297
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.36127146
28	tryptophan catabolic process (GO:0006569)	3.34617548
29	indole-containing compound catabolic process (GO:0042436)	3.34617548
30	indolalkylamine catabolic process (GO:0046218)	3.34617548
31	platelet dense granule organization (GO:0060155)	3.29355757
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.28619220
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.28619220
34	NADH dehydrogenase complex assembly (GO:0010257)	3.28619220
35	GTP biosynthetic process (GO:0006183)	3.27874034
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.25605807
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.23993969
38	ATP synthesis coupled proton transport (GO:0015986)	3.23993969
39	activated T cell proliferation (GO:0050798)	3.22424961
40	axoneme assembly (GO:0035082)	3.22154549
41	maturation of 5.8S rRNA (GO:0000460)	3.17342975
42	piRNA metabolic process (GO:0034587)	3.16364227
43	protein neddylation (GO:0045116)	3.15893781
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.15008148
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14203092
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.11740853
47	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.11001370
48	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.09688235
49	inositol phosphate dephosphorylation (GO:0046855)	3.09688235
50	ubiquinone biosynthetic process (GO:0006744)	3.09493783
51	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.07127609
52	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.06213624
53	branched-chain amino acid catabolic process (GO:0009083)	3.06212108
54	dopamine transport (GO:0015872)	3.05786556
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.05204823
56	termination of RNA polymerase III transcription (GO:0006386)	3.05204823
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04537618
58	inositol phosphate catabolic process (GO:0071545)	3.03298431
59	metallo-sulfur cluster assembly (GO:0031163)	3.03293396
60	iron-sulfur cluster assembly (GO:0016226)	3.03293396
61	methionine biosynthetic process (GO:0009086)	2.99110596
62	ubiquinone metabolic process (GO:0006743)	2.98030509
63	photoreceptor cell maintenance (GO:0045494)	2.96110709
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.94791107
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.94791107
66	protein K6-linked ubiquitination (GO:0085020)	2.93824199
67	rRNA catabolic process (GO:0016075)	2.88886889
68	positive regulation of mitochondrial fission (GO:0090141)	2.88188947
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.86551083
70	lactate metabolic process (GO:0006089)	2.84442225
71	glyoxylate metabolic process (GO:0046487)	2.82057544
72	polyol catabolic process (GO:0046174)	2.80610427
73	kidney morphogenesis (GO:0060993)	2.80389843
74	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.79644716
75	electron transport chain (GO:0022900)	2.78471077
76	adenosine metabolic process (GO:0046085)	2.77622133
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76610113
78	mannosylation (GO:0097502)	2.75689741
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.75194034
80	negative regulation of telomere maintenance (GO:0032205)	2.73646449
81	respiratory electron transport chain (GO:0022904)	2.72789314
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.72362107
83	methionine metabolic process (GO:0006555)	2.72211913
84	negative regulation of mast cell activation (GO:0033004)	2.68386017
85	UTP biosynthetic process (GO:0006228)	2.67842460
86	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.67507586
87	ATP hydrolysis coupled proton transport (GO:0015991)	2.65364337
88	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.65364337
89	protein polyglutamylation (GO:0018095)	2.65299133
90	regulation of microtubule-based movement (GO:0060632)	2.65135839
91	pyrimidine nucleobase catabolic process (GO:0006208)	2.60199453
92	anterograde synaptic vesicle transport (GO:0048490)	2.59712490
93	regulation of meiosis I (GO:0060631)	2.58809310
94	ATP biosynthetic process (GO:0006754)	2.54832025
95	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.53217514
96	quinone biosynthetic process (GO:1901663)	2.51635663
97	vitamin biosynthetic process (GO:0009110)	2.51112880
98	nonmotile primary cilium assembly (GO:0035058)	2.50976516
99	regulation of action potential (GO:0098900)	2.50779953
100	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.48376533

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.66283041
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.31910316
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.17288679
4	VDR_22108803_ChIP-Seq_LS180_Human	3.02445561
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.93322081
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.90492166
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.89085867
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.78814792
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77877808
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.23055229
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.18807502
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.14972228
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07939432
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.02221939
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00974710
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91097043
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.89277320
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89115126
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85528709
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.80072515
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79174565
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.74534463
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72612890
24	EWS_26573619_Chip-Seq_HEK293_Human	1.71329755
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69368304
26	FUS_26573619_Chip-Seq_HEK293_Human	1.68271715
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66141324
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.65157710
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64063314
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57236476
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.54645655
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54035960
33	NCOR_22424771_ChIP-Seq_293T_Human	1.51063371
34	AR_20517297_ChIP-Seq_VCAP_Human	1.50528014
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.50124654
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.47393699
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.47058865
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47058865
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47033597
40	P300_19829295_ChIP-Seq_ESCs_Human	1.46910199
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.46855919
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46777511
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46777511
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46162101
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42935911
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40968952
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40217822
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.35389511
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33687761
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32443874
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27696347
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27667834
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27115856
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24857665
55	FOXP3_21729870_ChIP-Seq_TREG_Human	1.23857802
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22348205
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21536111
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21536111
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18809474
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.17883313
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.17606030
62	MYC_19829295_ChIP-Seq_ESCs_Human	1.15712518
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13964034
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11985669
65	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11679551
66	AR_25329375_ChIP-Seq_VCAP_Human	1.09865288
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09523954
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09323434
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08152358
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07976275
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07313981
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07306158
73	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06353671
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06072697
75	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06029894
76	ERA_21632823_ChIP-Seq_H3396_Human	1.03462664
77	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02771943
78	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02628672
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02465132
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01214581
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00778143
82	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00688953
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00321813
84	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00036778
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99015733
86	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98720180
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98665100
88	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98398379
89	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.97613542
90	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.97493877
91	TCF4_23295773_ChIP-Seq_U87_Human	0.96657680
92	STAT3_23295773_ChIP-Seq_U87_Human	0.96597147
93	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95710198
94	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94164779
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92892215
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92497452
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92461429
98	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.91494368
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.90344112
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.90296631

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.48904918
2	MP0002163_abnormal_gland_morphology	4.04255527
3	MP0005379_endocrine/exocrine_gland_phen	3.26196593
4	MP0005646_abnormal_pituitary_gland	2.87696414
5	MP0002876_abnormal_thyroid_physiology	2.54376667
6	MP0003195_calcinosis	2.28666908
7	MP0005551_abnormal_eye_electrophysiolog	2.13126723
8	MP0008058_abnormal_DNA_repair	2.11543387
9	MP0008875_abnormal_xenobiotic_pharmacok	2.05396762
10	MP0001968_abnormal_touch/_nociception	2.05042310
11	MP0006072_abnormal_retinal_apoptosis	2.04165008
12	MP0001986_abnormal_taste_sensitivity	2.04105838
13	MP0005253_abnormal_eye_physiology	2.02909840
14	MP0002837_dystrophic_cardiac_calcinosis	2.01192062
15	MP0002736_abnormal_nociception_after	1.95414761
16	MP0002653_abnormal_ependyma_morphology	1.94065447
17	MP0000372_irregular_coat_pigmentation	1.89178312
18	MP0008877_abnormal_DNA_methylation	1.88289517
19	MP0004147_increased_porphyrin_level	1.87736278
20	MP0004043_abnormal_pH_regulation	1.85891707
21	MP0001984_abnormal_olfaction	1.78097676
22	MP0009046_muscle_twitch	1.74726460
23	MP0008872_abnormal_physiological_respon	1.71329294
24	MP0009745_abnormal_behavioral_response	1.68420589
25	MP0005084_abnormal_gallbladder_morpholo	1.64507853
26	MP0004885_abnormal_endolymph	1.58645552
27	MP0005645_abnormal_hypothalamus_physiol	1.55924927
28	MP0001529_abnormal_vocalization	1.54812206
29	MP0001346_abnormal_lacrimal_gland	1.50310169
30	MP0004142_abnormal_muscle_tone	1.43497679
31	MP0002638_abnormal_pupillary_reflex	1.41837555
32	MP0001764_abnormal_homeostasis	1.40915561
33	MP0006036_abnormal_mitochondrial_physio	1.39798975
34	MP0008789_abnormal_olfactory_epithelium	1.38240231
35	MP0000631_abnormal_neuroendocrine_gland	1.36727287
36	MP0001485_abnormal_pinna_reflex	1.34618617
37	MP0006276_abnormal_autonomic_nervous	1.30328192
38	MP0006292_abnormal_olfactory_placode	1.29053482
39	MP0005670_abnormal_white_adipose	1.28440104
40	MP0004145_abnormal_muscle_electrophysio	1.28109387
41	MP0002064_seizures	1.27051763
42	MP0003183_abnormal_peptide_metabolism	1.24154360
43	MP0003011_delayed_dark_adaptation	1.22399513
44	MP0008995_early_reproductive_senescence	1.22191843
45	MP0005075_abnormal_melanosome_morpholog	1.20691063
46	MP0004215_abnormal_myocardial_fiber	1.19659801
47	MP0005647_abnormal_sex_gland	1.19268643
48	MP0000427_abnormal_hair_cycle	1.16533958
49	MP0001486_abnormal_startle_reflex	1.14667299
50	MP0005167_abnormal_blood-brain_barrier	1.14655400
51	MP0000647_abnormal_sebaceous_gland	1.13248862
52	MP0002272_abnormal_nervous_system	1.11153111
53	MP0002733_abnormal_thermal_nociception	1.09637797
54	MP0001501_abnormal_sleep_pattern	1.09573283
55	MP0003186_abnormal_redox_activity	1.09257021
56	MP0003252_abnormal_bile_duct	1.08695895
57	MP0003136_yellow_coat_color	1.06343393
58	MP0001348_abnormal_lacrimal_gland	1.04990515
59	MP0002822_catalepsy	1.04723046
60	MP0001270_distended_abdomen	1.02143914
61	MP0003137_abnormal_impulse_conducting	1.00869804
62	MP0005389_reproductive_system_phenotype	1.00761702
63	MP0003786_premature_aging	1.00537263
64	MP0004133_heterotaxia	0.99327730
65	MP0002751_abnormal_autonomic_nervous	0.98103762
66	MP0002160_abnormal_reproductive_system	0.97914979
67	MP0001970_abnormal_pain_threshold	0.97741995
68	MP0005408_hypopigmentation	0.96482851
69	MP0005195_abnormal_posterior_eye	0.95747693
70	MP0001905_abnormal_dopamine_level	0.94960214
71	MP0003635_abnormal_synaptic_transmissio	0.93878186
72	MP0001502_abnormal_circadian_rhythm	0.93126940
73	MP0005187_abnormal_penis_morphology	0.92024678
74	MP0001919_abnormal_reproductive_system	0.91747365
75	MP0002572_abnormal_emotion/affect_behav	0.90506497
76	MP0000026_abnormal_inner_ear	0.90349032
77	MP0002735_abnormal_chemical_nociception	0.90201090
78	MP0004742_abnormal_vestibular_system	0.89645338
79	MP0002752_abnormal_somatic_nervous	0.89250646
80	MP0005499_abnormal_olfactory_system	0.87741712
81	MP0005394_taste/olfaction_phenotype	0.87741712
82	MP0005085_abnormal_gallbladder_physiolo	0.86851982
83	MP0009697_abnormal_copulation	0.85254046
84	MP0002095_abnormal_skin_pigmentation	0.85130042
85	MP0001929_abnormal_gametogenesis	0.84912103
86	MP0003806_abnormal_nucleotide_metabolis	0.84704788
87	MP0006035_abnormal_mitochondrial_morpho	0.84321844
88	MP0001963_abnormal_hearing_physiology	0.84156904
89	MP0002229_neurodegeneration	0.82132789
90	MP0002210_abnormal_sex_determination	0.81664710
91	MP0005391_vision/eye_phenotype	0.81223529
92	MP0005310_abnormal_salivary_gland	0.79856899
93	MP0002928_abnormal_bile_duct	0.79237547
94	MP0002067_abnormal_sensory_capabilities	0.78145153
95	MP0002557_abnormal_social/conspecific_i	0.77776247
96	MP0003698_abnormal_male_reproductive	0.77212577
97	MP0005410_abnormal_fertilization	0.75725803
98	MP0005332_abnormal_amino_acid	0.75122738
99	MP0000653_abnormal_sex_gland	0.74917203
100	MP0000778_abnormal_nervous_system	0.74557687

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.31982768
2	Pancreatic cysts (HP:0001737)	3.75415851
3	Pendular nystagmus (HP:0012043)	3.58956100
4	Abnormality of midbrain morphology (HP:0002418)	3.45853287
5	Molar tooth sign on MRI (HP:0002419)	3.45853287
6	Acute necrotizing encephalopathy (HP:0006965)	3.45655387
7	Mitochondrial inheritance (HP:0001427)	3.29229334
8	Pancreatic fibrosis (HP:0100732)	3.26633693
9	Congenital stationary night blindness (HP:0007642)	3.25046179
10	Increased CSF lactate (HP:0002490)	3.14526396
11	Abnormality of the renal cortex (HP:0011035)	3.08287384
12	True hermaphroditism (HP:0010459)	3.07521906
13	Acute encephalopathy (HP:0006846)	3.07404223
14	Hepatocellular necrosis (HP:0001404)	2.99197730
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.98355910
16	Progressive macrocephaly (HP:0004481)	2.87457113
17	Medial flaring of the eyebrow (HP:0010747)	2.85202876
18	Increased corneal curvature (HP:0100692)	2.85126407
19	Keratoconus (HP:0000563)	2.85126407
20	Hyperventilation (HP:0002883)	2.79500866
21	Hepatic necrosis (HP:0002605)	2.77451499
22	Type II lissencephaly (HP:0007260)	2.63123341
23	Abolished electroretinogram (ERG) (HP:0000550)	2.62844119
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.62190395
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58987981
26	Decreased central vision (HP:0007663)	2.57893354
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.57326740
28	Progressive microcephaly (HP:0000253)	2.57129395
29	Abnormality of the renal medulla (HP:0100957)	2.51511758
30	Nephronophthisis (HP:0000090)	2.48283032
31	Hyperglycinemia (HP:0002154)	2.48257711
32	Oligodactyly (hands) (HP:0001180)	2.46790263
33	Hypoproteinemia (HP:0003075)	2.44486293
34	Large for gestational age (HP:0001520)	2.43321682
35	Gait imbalance (HP:0002141)	2.37157623
36	Limb dystonia (HP:0002451)	2.35096533
37	Hyperglycinuria (HP:0003108)	2.35092922
38	Congenital primary aphakia (HP:0007707)	2.29140498
39	Aplasia/hypoplasia of the uterus (HP:0008684)	2.28941122
40	Renal cortical cysts (HP:0000803)	2.27901420
41	Increased serum lactate (HP:0002151)	2.27131387
42	Optic disc pallor (HP:0000543)	2.26711493
43	Nephrogenic diabetes insipidus (HP:0009806)	2.24789384
44	Abnormality of glycine metabolism (HP:0010895)	2.23306388
45	Abnormality of serine family amino acid metabolism (HP:0010894)	2.23306388
46	Abnormality of alanine metabolism (HP:0010916)	2.21351152
47	Hyperalaninemia (HP:0003348)	2.21351152
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.21351152
49	Cerebral edema (HP:0002181)	2.19469478
50	Lactic acidosis (HP:0003128)	2.17995467
51	Attenuation of retinal blood vessels (HP:0007843)	2.17403493
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.17106971
53	Abnormality of lateral ventricle (HP:0030047)	2.16764797
54	Asplenia (HP:0001746)	2.09602748
55	Abnormal drinking behavior (HP:0030082)	2.08559179
56	Polydipsia (HP:0001959)	2.08559179
57	Respiratory failure (HP:0002878)	2.04917562
58	Severe muscular hypotonia (HP:0006829)	2.02513841
59	Cystic liver disease (HP:0006706)	1.98179563
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97007053
61	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97007053
62	Hypomagnesemia (HP:0002917)	1.95426758
63	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.95272527
64	Hypoplasia of the fovea (HP:0007750)	1.95272527
65	Sclerocornea (HP:0000647)	1.95112964
66	Genital tract atresia (HP:0001827)	1.94056531
67	Cerebellar dysplasia (HP:0007033)	1.92893791
68	Hypoplasia of the uterus (HP:0000013)	1.89819517
69	Pachygyria (HP:0001302)	1.89747709
70	Cerebral hypomyelination (HP:0006808)	1.89218639
71	Ketosis (HP:0001946)	1.89020747
72	Lethargy (HP:0001254)	1.88644501
73	Broad-based gait (HP:0002136)	1.87893385
74	Progressive inability to walk (HP:0002505)	1.86040947
75	Polyuria (HP:0000103)	1.84696972
76	Tubular atrophy (HP:0000092)	1.84239048
77	CNS demyelination (HP:0007305)	1.84059359
78	Vaginal atresia (HP:0000148)	1.83849815
79	Retinal dysplasia (HP:0007973)	1.80763937
80	Lissencephaly (HP:0001339)	1.79831177
81	Abnormality of the fovea (HP:0000493)	1.79823097
82	Methylmalonic aciduria (HP:0012120)	1.79040312
83	Diastasis recti (HP:0001540)	1.77091857
84	Abnormality of the labia minora (HP:0012880)	1.75926491
85	Lipid accumulation in hepatocytes (HP:0006561)	1.75333432
86	Oculomotor apraxia (HP:0000657)	1.74698262
87	Polyphagia (HP:0002591)	1.74220278
88	Febrile seizures (HP:0002373)	1.74155997
89	Abnormality of the renal collecting system (HP:0004742)	1.73464964
90	Methylmalonic acidemia (HP:0002912)	1.71706940
91	Constricted visual fields (HP:0001133)	1.71099088
92	Oligodactyly (HP:0012165)	1.68752983
93	Colon cancer (HP:0003003)	1.68682330
94	Anencephaly (HP:0002323)	1.68252192
95	Dyskinesia (HP:0100660)	1.68119406
96	Bile duct proliferation (HP:0001408)	1.67912803
97	Abnormal biliary tract physiology (HP:0012439)	1.67912803
98	Concave nail (HP:0001598)	1.67317627
99	Parakeratosis (HP:0001036)	1.66497507
100	Mesangial abnormality (HP:0001966)	1.66369372

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.37874505
2	FRK	3.31091001
3	WNK3	3.29221206
4	NUAK1	2.85908813
5	CASK	2.62332910
6	MAP3K4	2.61231644
7	STK39	2.59021683
8	ZAK	2.56491032
9	INSRR	2.49018578
10	WNK4	2.45992242
11	TLK1	2.16921115
12	MAP4K2	2.13695806
13	CDK19	2.10160524
14	SIK2	2.09702968
15	CAMKK2	2.04164081
16	ADRBK2	1.95589721
17	GRK1	1.94136583
18	OXSR1	1.86948899
19	BCR	1.82282142
20	PINK1	1.63988005
21	CSNK1G3	1.57286122
22	STK38L	1.52332384
23	MAPK13	1.51000519
24	DYRK2	1.48329009
25	MAP2K7	1.45017702
26	TAOK3	1.41586168
27	CSNK1A1L	1.38420026
28	PRKD3	1.37810724
29	MUSK	1.33804799
30	CSNK1G2	1.32650954
31	ACVR1B	1.22627594
32	BCKDK	1.20223324
33	CSNK1G1	1.14447739
34	BMPR1B	1.07744682
35	MAP2K6	0.96589752
36	TRIM28	0.92656681
37	EIF2AK1	0.91907850
38	DYRK3	0.90244964
39	PRKCE	0.89448852
40	GRK7	0.89080496
41	VRK2	0.87534301
42	RPS6KA4	0.84233811
43	PHKG1	0.84169003
44	PHKG2	0.84169003
45	NEK2	0.83809312
46	ADRBK1	0.82956717
47	DAPK2	0.82214716
48	VRK1	0.80370891
49	ERBB3	0.78916925
50	PRKCG	0.78103706
51	GRK5	0.75688358
52	PTK2B	0.75507404
53	TAOK1	0.75377025
54	KDR	0.70903964
55	RPS6KA5	0.69457862
56	BRSK2	0.69395467
57	PAK3	0.63727053
58	PIK3CG	0.62698005
59	PLK2	0.60714708
60	FES	0.60403850
61	IKBKB	0.60369396
62	EPHA4	0.60180500
63	ATR	0.58511982
64	FER	0.58141231
65	PRKCI	0.57176903
66	BUB1	0.56057009
67	PLK4	0.54137490
68	CAMK2A	0.50998398
69	TNIK	0.48235348
70	PIM2	0.48065069
71	AKT3	0.47225255
72	OBSCN	0.46737003
73	MKNK2	0.45593023
74	TEC	0.45471850
75	STK3	0.44793581
76	PRKCH	0.44181996
77	SRPK1	0.43895302
78	PRKACA	0.43764994
79	PRKCQ	0.42951428
80	IRAK4	0.42783757
81	ITK	0.41708074
82	NME1	0.41684960
83	EPHA3	0.40889222
84	PAK6	0.40505339
85	CAMKK1	0.40384637
86	CAMK1D	0.38724658
87	CAMK1	0.37877870
88	TIE1	0.36993566
89	EIF2AK2	0.36219205
90	CSNK1A1	0.35824992
91	STK38	0.34528793
92	BMPR2	0.33425524
93	ABL1	0.33166857
94	PRKCA	0.32272949
95	CAMK4	0.32227890
96	ATM	0.30950859
97	DAPK1	0.30597146
98	PLK3	0.30284568
99	TGFBR2	0.30084533
100	NTRK2	0.29997854

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.32362648
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.83950389
3	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.54374321
4	Parkinsons disease_Homo sapiens_hsa05012	2.50502691
5	Protein export_Homo sapiens_hsa03060	2.46097503
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44080454
7	RNA polymerase_Homo sapiens_hsa03020	2.40956731
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.23261131
9	Phototransduction_Homo sapiens_hsa04744	2.18453686
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.16547812
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14142870
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.03132783
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.80062026
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.72036294
15	Proteasome_Homo sapiens_hsa03050	1.70858386
16	Huntingtons disease_Homo sapiens_hsa05016	1.66758885
17	One carbon pool by folate_Homo sapiens_hsa00670	1.66366422
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.64469503
19	Alzheimers disease_Homo sapiens_hsa05010	1.59774803
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.53686234
21	Fatty acid elongation_Homo sapiens_hsa00062	1.52443182
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.51674045
23	Butanoate metabolism_Homo sapiens_hsa00650	1.49289071
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.47937799
25	Propanoate metabolism_Homo sapiens_hsa00640	1.43861887
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.41361511
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39777845
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39454677
29	Peroxisome_Homo sapiens_hsa04146	1.38099822
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36887034
31	Sulfur metabolism_Homo sapiens_hsa00920	1.36594719
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.33690434
33	RNA degradation_Homo sapiens_hsa03018	1.32332555
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32219210
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.29329183
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.28196722
37	Regulation of autophagy_Homo sapiens_hsa04140	1.27680842
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24987972
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.24808260
40	Nicotine addiction_Homo sapiens_hsa05033	1.22618834
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21240571
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18484089
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10086546
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09191825
45	DNA replication_Homo sapiens_hsa03030	1.08343230
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07627085
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06174848
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05915138
49	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.03933841
50	Fatty acid degradation_Homo sapiens_hsa00071	1.00031778
51	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99589871
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.98877750
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97407355
54	Metabolic pathways_Homo sapiens_hsa01100	0.93662091
55	Purine metabolism_Homo sapiens_hsa00230	0.93078357
56	Caffeine metabolism_Homo sapiens_hsa00232	0.91491362
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88841093
58	Homologous recombination_Homo sapiens_hsa03440	0.88209123
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87195069
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85810560
61	Mismatch repair_Homo sapiens_hsa03430	0.84910267
62	Taste transduction_Homo sapiens_hsa04742	0.84432372
63	Morphine addiction_Homo sapiens_hsa05032	0.83526884
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.81993084
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81852053
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81382001
67	Base excision repair_Homo sapiens_hsa03410	0.81248561
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.77592392
69	Retinol metabolism_Homo sapiens_hsa00830	0.77458307
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.77008713
71	GABAergic synapse_Homo sapiens_hsa04727	0.76431433
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76226846
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.76077421
74	Olfactory transduction_Homo sapiens_hsa04740	0.74059958
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73393115
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.63989884
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.63504242
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63076003
79	Basal transcription factors_Homo sapiens_hsa03022	0.60924960
80	ABC transporters_Homo sapiens_hsa02010	0.60597846
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.56802360
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.56786058
83	Ribosome_Homo sapiens_hsa03010	0.55556043
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.55443907
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54906334
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52681185
87	RNA transport_Homo sapiens_hsa03013	0.51270337
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49883869
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48751154
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47861961
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47396303
92	Spliceosome_Homo sapiens_hsa03040	0.45430205
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43619637
94	Non-homologous end-joining_Homo sapiens_hsa03450	0.43505245
95	Serotonergic synapse_Homo sapiens_hsa04726	0.43384764
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40142999
97	Sulfur relay system_Homo sapiens_hsa04122	0.39399054
98	Insulin secretion_Homo sapiens_hsa04911	0.39373952
99	Circadian entrainment_Homo sapiens_hsa04713	0.33104765
100	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.32760873

OR6K1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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