ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to ATP (GO:0071318)	9.64980024
2	DNA strand renaturation (GO:0000733)	9.59927830
3	peptidyl-glutamic acid carboxylation (GO:0017187)	9.18644336
4	protein carboxylation (GO:0018214)	9.18644336
5	regulation of synapse structural plasticity (GO:0051823)	8.61971534
6	GDP-mannose metabolic process (GO:0019673)	8.51668441
7	mitotic cell cycle arrest (GO:0071850)	8.31423768
8	meiotic chromosome segregation (GO:0045132)	7.77475288
9	adenosine receptor signaling pathway (GO:0001973)	7.72733025
10	lens fiber cell differentiation (GO:0070306)	7.33121784
11	regulation of cytokine production involved in inflammatory response (GO:1900015)	7.16971576
12	transepithelial transport (GO:0070633)	6.92668046
13	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	6.84294066
14	purinergic nucleotide receptor signaling pathway (GO:0035590)	6.35264027
15	detection of light stimulus involved in sensory perception (GO:0050962)	6.34390101
16	detection of light stimulus involved in visual perception (GO:0050908)	6.34390101
17	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	6.19514661
18	estrogen biosynthetic process (GO:0006703)	5.67255347
19	positive regulation of heat generation (GO:0031652)	5.46582934
20	positive regulation of protein kinase C signaling (GO:0090037)	5.16702448
21	response to ATP (GO:0033198)	5.15612391
22	granulocyte differentiation (GO:0030851)	4.97885400
23	sensory perception of taste (GO:0050909)	4.90841901
24	rRNA methylation (GO:0031167)	4.89975105
25	semaphorin-plexin signaling pathway (GO:0071526)	4.82380856
26	regulation of phospholipid biosynthetic process (GO:0071071)	4.78324220
27	purinergic receptor signaling pathway (GO:0035587)	4.61358242
28	regulation of cell aging (GO:0090342)	4.58625564
29	negative regulation of interleukin-8 production (GO:0032717)	4.53204682
30	phosphatidylglycerol biosynthetic process (GO:0006655)	4.51749535
31	adenine nucleotide transport (GO:0051503)	4.45051660
32	purine ribonucleotide transport (GO:0015868)	4.32853738
33	sphingomyelin metabolic process (GO:0006684)	4.32642378
34	mannose metabolic process (GO:0006013)	4.29837126
35	sulfur amino acid catabolic process (GO:0000098)	4.27562996
36	nucleotide-sugar biosynthetic process (GO:0009226)	4.26290621
37	urinary tract smooth muscle contraction (GO:0014848)	4.24177739
38	behavioral response to nicotine (GO:0035095)	4.20008862
39	peptidyl-glutamic acid modification (GO:0018200)	4.18223670
40	rRNA modification (GO:0000154)	4.17754752
41	sphingosine metabolic process (GO:0006670)	4.16080107
42	regulation of heat generation (GO:0031650)	4.10478508
43	UV protection (GO:0009650)	4.08101976
44	cilium or flagellum-dependent cell motility (GO:0001539)	4.06418703
45	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	4.05049124
46	phosphate ion homeostasis (GO:0055062)	4.00732494
47	trivalent inorganic anion homeostasis (GO:0072506)	4.00732494
48	cellular anion homeostasis (GO:0030002)	3.93063120
49	type B pancreatic cell proliferation (GO:0044342)	3.93003805
50	cardiolipin metabolic process (GO:0032048)	3.92549390
51	peristalsis (GO:0030432)	3.86107880
52	diol metabolic process (GO:0034311)	3.84043221
53	melanin biosynthetic process (GO:0042438)	3.76332874
54	nucleoside transmembrane transport (GO:1901642)	3.75507684
55	proline biosynthetic process (GO:0006561)	3.70216193
56	grooming behavior (GO:0007625)	3.66943977
57	endocytic recycling (GO:0032456)	3.63970643
58	phosphate ion transmembrane transport (GO:0035435)	3.54815619
59	nucleotide transmembrane transport (GO:1901679)	3.54357574
60	mitochondrion distribution (GO:0048311)	3.53295633
61	folic acid metabolic process (GO:0046655)	3.53069201
62	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.50358101
63	regulation of protein kinase A signaling (GO:0010738)	3.46809389
64	purine nucleotide transport (GO:0015865)	3.44531749
65	melanin metabolic process (GO:0006582)	3.44146336
66	DNA replication checkpoint (GO:0000076)	3.42399921
67	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.38736286
68	sex determination (GO:0007530)	3.36339255
69	histone phosphorylation (GO:0016572)	3.33845260
70	heme transport (GO:0015886)	3.33188632
71	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.28396343
72	iron coordination entity transport (GO:1901678)	3.16851467
73	neuromuscular synaptic transmission (GO:0007274)	3.14899963
74	phosphatidylethanolamine metabolic process (GO:0046337)	3.13112622
75	sphingoid metabolic process (GO:0046519)	3.11903791
76	folic acid transport (GO:0015884)	3.09525721
77	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.06866871
78	protein insertion into membrane (GO:0051205)	3.05192635
79	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.03330944
80	purine deoxyribonucleotide catabolic process (GO:0009155)	3.02791713
81	response to gravity (GO:0009629)	2.99426438
82	secondary metabolite biosynthetic process (GO:0044550)	2.99302370
83	muscle fiber development (GO:0048747)	2.98866914
84	regulation of meiosis (GO:0040020)	2.97085059
85	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.94917460
86	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.94917460
87	activation of adenylate cyclase activity (GO:0007190)	2.93450698
88	proline metabolic process (GO:0006560)	2.92782128
89	sialylation (GO:0097503)	2.91368121
90	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.89739300
91	DNA duplex unwinding (GO:0032508)	2.88740288
92	phosphate ion transport (GO:0006817)	2.86457212
93	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.85586183
94	regulation of guanylate cyclase activity (GO:0031282)	2.84316116
95	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.84215143
96	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.84215143
97	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.84215143
98	cell migration in hindbrain (GO:0021535)	2.78274327
99	regulation of skeletal muscle contraction (GO:0014819)	10.4501706
100	negative regulation of cell aging (GO:0090344)	10.1186545

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	4.41103235
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.71202324
3	P68_20966046_ChIP-Seq_HELA_Human	3.21279083
4	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.19428160
5	LXR_22292898_ChIP-Seq_THP-1_Human	3.03375336
6	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.87187257
7	XRN2_22483619_ChIP-Seq_HELA_Human	2.78640357
8	MAF_26560356_Chip-Seq_TH2_Human	2.64064258
9	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.56075111
10	E2F1_20622854_ChIP-Seq_HELA_Human	2.54289810
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.45131672
12	BCOR_27268052_Chip-Seq_Bcells_Human	2.36263608
13	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.35256954
14	BCL6_27268052_Chip-Seq_Bcells_Human	2.32388305
15	CTCF_27219007_Chip-Seq_Bcells_Human	2.29379462
16	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.27439826
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.26483827
18	RACK7_27058665_Chip-Seq_MCF-7_Human	2.25803943
19	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.23569026
20	PHF8_20622854_ChIP-Seq_HELA_Human	2.20448426
21	CTCF_27219007_Chip-Seq_ERYTHROID_Human	2.18548922
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.12986018
23	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.08691449
24	MAF_26560356_Chip-Seq_TH1_Human	2.06973003
25	RARB_24833708_ChIP-Seq_LIVER_Mouse	2.06727486
26	VDR_24763502_ChIP-Seq_THP-1_Human	2.06163338
27	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	2.05326284
28	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.04364817
29	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.97703844
30	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.95329402
31	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.95058803
32	SMC4_20622854_ChIP-Seq_HELA_Human	1.89217151
33	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.84989333
34	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.83682528
35	CTCF_21964334_Chip-Seq_Bcells_Human	1.83267464
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.81242332
37	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.80548548
38	TP53_22127205_ChIP-Seq_IMR90_Human	1.76793849
39	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.76449172
40	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.74150248
41	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.73298323
42	CTCF_20526341_ChIP-Seq_ESCs_Human	1.72562249
43	MYC_22102868_ChIP-Seq_BL_Human	1.71319991
44	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.71283875
45	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.70025247
46	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68099305
47	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.68089717
48	KDM2B_26808549_Chip-Seq_DND41_Human	1.66045690
49	UTX_26944678_Chip-Seq_JUKART_Human	1.62733606
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.62121293
51	CREB1_26743006_Chip-Seq_LNCaP_Human	1.59282812
52	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.58832418
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.53253082
54	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.49186091
55	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.48887805
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.41230373
57	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.40360578
58	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.40124882
59	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.40010592
60	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.39977187
61	ERA_21632823_ChIP-Seq_H3396_Human	1.39555780
62	TCF7_22412390_ChIP-Seq_EML_Mouse	1.39050457
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.38397960
64	SA1_27219007_Chip-Seq_Bcells_Human	1.37953527
65	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.37509499
66	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.33072192
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.29447203
68	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.28974971
69	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.25628558
70	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.24580967
71	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.23293736
72	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.22588074
73	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.21189004
74	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.20434289
75	ATF3_27146783_Chip-Seq_COLON_Human	1.20032229
76	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.19404034
77	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.17778969
78	P300_27268052_Chip-Seq_Bcells_Human	1.15072882
79	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.14183575
80	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.13460653
81	NANOG_20526341_ChIP-Seq_ESCs_Human	1.13394638
82	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.13161656
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.11462652
84	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.11367044
85	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.10524999
86	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.09035032
87	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07144715
88	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.06037084
89	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05848816
90	TP63_22573176_ChIP-Seq_HFKS_Human	1.05773962
91	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.04719394
92	GABP_19822575_ChIP-Seq_HepG2_Human	1.03891753
93	OCT4_19829295_ChIP-Seq_ESCs_Human	1.03424435
94	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.03330001
95	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.02638049
96	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.02193829
97	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.01002609
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00576342
99	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.00166307
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99958406

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	8.19569840
2	MP0001986_abnormal_taste_sensitivity	6.18794654
3	MP0005174_abnormal_tail_pigmentation	6.07470053
4	MP0005423_abnormal_somatic_nervous	5.44545411
5	MP0003136_yellow_coat_color	4.92904786
6	MP0008875_abnormal_xenobiotic_pharmacok	3.52342168
7	MP0005409_darkened_coat_color	3.25741567
8	MP0000751_myopathy	3.24438186
9	MP0001188_hyperpigmentation	3.00620150
10	MP0005083_abnormal_biliary_tract	3.00305491
11	MP0001661_extended_life_span	2.78659663
12	MP0001756_abnormal_urination	2.40485467
13	MP0001968_abnormal_touch/_nociception	2.40371830
14	MP0005330_cardiomyopathy	2.21418102
15	MP0001502_abnormal_circadian_rhythm	2.20596552
16	MP0002160_abnormal_reproductive_system	2.16563207
17	MP0002638_abnormal_pupillary_reflex	2.14108881
18	MP0003453_abnormal_keratinocyte_physiol	2.01125597
19	MP0000750_abnormal_muscle_regeneration	1.98719819
20	MP0000015_abnormal_ear_pigmentation	1.91189020
21	MP0004130_abnormal_muscle_cell	1.86481333
22	MP0002736_abnormal_nociception_after	1.76164541
23	MP0004381_abnormal_hair_follicle	1.73695740
24	MP0000538_abnormal_urinary_bladder	1.61321655
25	MP0005410_abnormal_fertilization	1.52767643
26	MP0003111_abnormal_nucleus_morphology	1.51513735
27	MP0000013_abnormal_adipose_tissue	1.49320922
28	MP0003705_abnormal_hypodermis_morpholog	1.44382787
29	MP0005501_abnormal_skin_physiology	1.40891706
30	MP0005332_abnormal_amino_acid	1.40701506
31	MP0002254_reproductive_system_inflammat	1.37291817
32	MP0001919_abnormal_reproductive_system	1.36046118
33	MP0002735_abnormal_chemical_nociception	1.34949129
34	MP0005551_abnormal_eye_electrophysiolog	1.29881477
35	MP0000747_muscle_weakness	1.25681029
36	MP0001958_emphysema	1.23850906
37	MP0005365_abnormal_bile_salt	1.15104827
38	MP0001765_abnormal_ion_homeostasis	1.13320962
39	MP0005257_abnormal_intraocular_pressure	1.13297837
40	MP0004043_abnormal_pH_regulation	1.10240701
41	MP0005377_hearing/vestibular/ear_phenot	1.07412679
42	MP0003878_abnormal_ear_physiology	1.07412679
43	MP0000003_abnormal_adipose_tissue	1.06166934
44	MP0003806_abnormal_nucleotide_metabolis	1.05749592
45	MP0000470_abnormal_stomach_morphology	1.04949047
46	MP0005076_abnormal_cell_differentiation	1.04926336
47	MP0003077_abnormal_cell_cycle	0.99889994
48	MP0001664_abnormal_digestion	0.97123495
49	MP0005389_reproductive_system_phenotype	0.89102847
50	MP0002909_abnormal_adrenal_gland	0.87391217
51	MP0003137_abnormal_impulse_conducting	0.87316011
52	MP0001324_abnormal_eye_pigmentation	0.87131499
53	MP0000367_abnormal_coat/_hair	0.84464623
54	MP0004019_abnormal_vitamin_homeostasis	0.83901251
55	MP0005584_abnormal_enzyme/coenzyme_acti	0.83877212
56	MP0001348_abnormal_lacrimal_gland	0.80585351
57	MP0005253_abnormal_eye_physiology	0.77896865
58	MP0005084_abnormal_gallbladder_morpholo	0.77227578
59	MP0009643_abnormal_urine_homeostasis	0.77186170
60	MP0004215_abnormal_myocardial_fiber	0.76703807
61	MP0005058_abnormal_lysosome_morphology	0.75115882
62	MP0003448_altered_tumor_morphology	0.72741705
63	MP0001873_stomach_inflammation	0.72116010
64	MP0003091_abnormal_cell_migration	0.71561017
65	MP0010771_integument_phenotype	0.67940094
66	MP0000358_abnormal_cell_content/	0.67323252
67	MP0009931_abnormal_skin_appearance	0.65557439
68	MP0005023_abnormal_wound_healing	0.62623316
69	MP0010094_abnormal_chromosome_stability	0.62426254
70	MP0004197_abnormal_fetal_growth/weight/	0.60734213
71	MP0002933_joint_inflammation	0.60727166
72	MP0004957_abnormal_blastocyst_morpholog	0.58219212
73	MP0002060_abnormal_skin_morphology	0.56828217
74	MP0008770_decreased_survivor_rate	0.56772914
75	MP0009384_cardiac_valve_regurgitation	0.55664033
76	MP0001905_abnormal_dopamine_level	0.54887207
77	MP0001346_abnormal_lacrimal_gland	0.54641432
78	MP0002019_abnormal_tumor_incidence	0.53774318
79	MP0001191_abnormal_skin_condition	0.52987873
80	MP0009840_abnormal_foam_cell	0.52985596
81	MP0002136_abnormal_kidney_physiology	0.52260640
82	MP0002075_abnormal_coat/hair_pigmentati	0.52111902
83	MP0004087_abnormal_muscle_fiber	0.51990595
84	MP0001970_abnormal_pain_threshold	0.50480377
85	MP0010386_abnormal_urinary_bladder	0.49325258
86	MP0002928_abnormal_bile_duct	0.49137468
87	MP0004185_abnormal_adipocyte_glucose	0.46883012
88	MP0002118_abnormal_lipid_homeostasis	0.46782133
89	MP0005220_abnormal_exocrine_pancreas	0.45054418
90	MP0003172_abnormal_lysosome_physiology	0.43487984
91	MP0000377_abnormal_hair_follicle	0.43483279
92	MP0002210_abnormal_sex_determination	0.42492310
93	MP0001784_abnormal_fluid_regulation	0.41761670
94	MP0005375_adipose_tissue_phenotype	0.40289975
95	MP0009278_abnormal_bone_marrow	0.36142296
96	MP0003632_abnormal_nervous_system	0.34356742
97	MP0003303_peritoneal_inflammation	0.34114484
98	MP0010769_abnormal_survival	0.31273139
99	MP0000759_abnormal_skeletal_muscle	0.31183068
100	MP0010768_mortality/aging	0.29443986

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	7.00005156
2	Rib fusion (HP:0000902)	6.60208916
3	Dyschromatopsia (HP:0007641)	6.09098614
4	Mesangial abnormality (HP:0001966)	5.66666076
5	Attenuation of retinal blood vessels (HP:0007843)	5.53198948
6	Rectal fistula (HP:0100590)	5.04220510
7	Rectovaginal fistula (HP:0000143)	5.04220510
8	Poikiloderma (HP:0001029)	4.94368058
9	Abnormality of the intrinsic pathway (HP:0010989)	4.93980512
10	Intestinal fistula (HP:0100819)	4.82596024
11	Thin bony cortex (HP:0002753)	4.78657908
12	Prolonged partial thromboplastin time (HP:0003645)	4.76776913
13	Joint hemorrhage (HP:0005261)	4.70856738
14	Ulnar bowing (HP:0003031)	4.70039732
15	Facial diplegia (HP:0001349)	4.65001545
16	Popliteal pterygium (HP:0009756)	4.63718245
17	Annular pancreas (HP:0001734)	4.63009468
18	Vaginal fistula (HP:0004320)	4.62238608
19	Hemorrhage of the eye (HP:0011885)	4.58881947
20	Akinesia (HP:0002304)	4.52004282
21	Facial hemangioma (HP:0000329)	4.50879379
22	Increased hepatocellular lipid droplets (HP:0006565)	4.38232475
23	Turricephaly (HP:0000262)	4.18936812
24	Choroideremia (HP:0001139)	4.17075862
25	Renal Fanconi syndrome (HP:0001994)	4.15747894
26	Lipid accumulation in hepatocytes (HP:0006561)	4.12310495
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.04729264
28	Aplasia of the musculature (HP:0100854)	3.97655394
29	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.91445731
30	Coronal craniosynostosis (HP:0004440)	3.89978757
31	Fetal akinesia sequence (HP:0001989)	3.85674565
32	Congenital stationary night blindness (HP:0007642)	3.85585392
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.60424322
34	Decreased central vision (HP:0007663)	3.57310971
35	Atrioventricular block (HP:0001678)	3.55350557
36	Bony spicule pigmentary retinopathy (HP:0007737)	3.48035465
37	Squamous cell carcinoma (HP:0002860)	3.42027903
38	Hypoalbuminemia (HP:0003073)	3.41165254
39	Abnormal albumin level (HP:0012116)	3.41165254
40	Delayed epiphyseal ossification (HP:0002663)	3.41038964
41	Anteriorly placed anus (HP:0001545)	3.35764845
42	Chorioretinal atrophy (HP:0000533)	3.29168261
43	Abnormality of placental membranes (HP:0011409)	3.28763665
44	Amniotic constriction ring (HP:0009775)	3.28763665
45	Short chin (HP:0000331)	3.27177680
46	Myotonia (HP:0002486)	3.26888287
47	Patellar aplasia (HP:0006443)	3.21815166
48	Aplasia/Hypoplasia of the patella (HP:0006498)	2.96715202
49	Increased intramyocellular lipid droplets (HP:0012240)	2.95824735
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.93948987
51	Abnormality of the costochondral junction (HP:0000919)	2.91222650
52	Zonular cataract (HP:0010920)	2.89458604
53	Hypophosphatemic rickets (HP:0004912)	2.87819570
54	Exertional dyspnea (HP:0002875)	2.84315580
55	Enlarged epiphyses (HP:0010580)	2.83202147
56	Increased muscle lipid content (HP:0009058)	2.81556118
57	Abnormality of the common coagulation pathway (HP:0010990)	2.78720391
58	Neonatal respiratory distress (HP:0002643)	2.75311974
59	Neonatal onset (HP:0003623)	2.74309435
60	Capillary hemangiomas (HP:0005306)	2.67737814
61	Widely patent fontanelles and sutures (HP:0004492)	2.52996061
62	Bowing of the arm (HP:0006488)	2.52314938
63	Bowed forearm bones (HP:0003956)	2.52314938
64	Joint stiffness (HP:0001387)	2.51571149
65	Respiratory difficulties (HP:0002880)	2.46811164
66	Abnormal urine phosphate concentration (HP:0012599)	2.42193679
67	Absent thumb (HP:0009777)	2.40069167
68	Choanal stenosis (HP:0000452)	2.39692714
69	Narrow nasal bridge (HP:0000446)	2.39031936
70	Abnormality of renal resorption (HP:0011038)	2.37993672
71	Thin ribs (HP:0000883)	2.32672689
72	Abnormal epiphyseal ossification (HP:0010656)	2.31450476
73	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.29031139
74	Long clavicles (HP:0000890)	2.26558860
75	Increased number of teeth (HP:0011069)	2.24715954
76	Flat occiput (HP:0005469)	2.22368176
77	Premature graying of hair (HP:0002216)	2.20165018
78	Malignant hyperthermia (HP:0002047)	2.19232419
79	Pterygium (HP:0001059)	2.18925912
80	Heart block (HP:0012722)	2.18140783
81	Basal cell carcinoma (HP:0002671)	2.17499719
82	Short humerus (HP:0005792)	2.17362377
83	Diminished movement (HP:0002374)	2.08853015
84	Abnormal atrioventricular conduction (HP:0005150)	2.05186835
85	Epiphyseal stippling (HP:0010655)	2.04414298
86	Cystic hygroma (HP:0000476)	2.02627930
87	Myopathic facies (HP:0002058)	2.02391592
88	Birth length less than 3rd percentile (HP:0003561)	2.02168554
89	Macular degeneration (HP:0000608)	1.94560474
90	Aplasia/hypoplasia of the humerus (HP:0006507)	1.94304131
91	Abnormality of the hepatic vasculature (HP:0006707)	1.93310425
92	Absent radius (HP:0003974)	1.88130773
93	Cheilitis (HP:0100825)	1.85792245
94	Mask-like facies (HP:0000298)	1.84752316
95	Fatigable weakness (HP:0003473)	1.80499350
96	Abnormality of the neuromuscular junction (HP:0003398)	1.80499350
97	Cholelithiasis (HP:0001081)	1.79886040
98	Renal tubular dysfunction (HP:0000124)	1.79207281
99	Abnormal drinking behavior (HP:0030082)	1.75605876
100	Polydipsia (HP:0001959)	1.75605876

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.93581274
2	MUSK	4.15642697
3	BLK	3.23322283
4	TLK1	2.19550923
5	MAPK15	11.9354947
6	SIK2	1.92109877
7	TRIB3	1.90875981
8	TESK2	1.83966252
9	STK16	1.55896176
10	WNK1	1.54734691
11	GRK6	1.51422937
12	SIK1	1.48548221
13	CCNB1	1.45527773
14	ADRBK1	1.40626503
15	ERN1	1.36377193
16	BMX	1.26811787
17	MAP2K3	1.26490635
18	ACVR1B	1.25309050
19	PDPK1	1.24754037
20	CDK4	1.24407140
21	IRAK2	1.22305642
22	DYRK1B	1.19461852
23	NEK2	1.15940458
24	ZAP70	1.10299467
25	CDK6	1.09188629
26	CDK15	1.08928263
27	ADRBK2	1.04121101
28	MAP2K6	1.02889121
29	CSK	1.02022764
30	CDK18	1.01693474
31	CDK11A	1.00070572
32	ZAK	0.98620315
33	PRKD2	0.96871122
34	MST1R	0.88313197
35	TRIM28	0.83838473
36	STK39	0.79652165
37	PAK1	0.79396550
38	TBK1	0.78831110
39	PRKD1	0.74817547
40	CDK14	0.70506005
41	RPS6KA2	0.69037794
42	ICK	0.65647004
43	BMPR1B	0.65321991
44	MAPK11	0.64663020
45	AURKA	0.63926911
46	MELK	0.62924443
47	RPS6KA6	0.62460577
48	STK11	0.57895936
49	EEF2K	0.54383725
50	RPS6KL1	0.52714200
51	RPS6KC1	0.52714200
52	DAPK2	0.52657844
53	CHEK2	0.51503540
54	EPHA2	0.51265902
55	ATR	0.49365643
56	MTOR	0.49226500
57	CSNK1D	0.49169832
58	MAPK8	0.47251195
59	PLK1	0.44322310
60	MAPK12	0.43830724
61	PKN2	0.43755707
62	PRKAA1	0.42797687
63	EPHB2	0.39461700
64	OXSR1	0.38307060
65	CDK12	0.38033886
66	PIM2	0.37302383
67	IKBKE	0.37049774
68	PRKD3	0.36874119
69	ARAF	0.34264585
70	MARK2	0.32754490
71	IKBKB	0.30953979
72	RPS6KA5	0.29464660
73	TGFBR1	0.28880591
74	CDK1	0.28673492
75	TTN	0.25219208
76	SGK223	0.25140179
77	SGK494	0.25140179
78	STK38	0.23776432
79	SIK3	0.23365542
80	PRKCH	0.21742148
81	CDK5	0.20855208
82	MET	0.20721984
83	PHKG2	0.19518253
84	PHKG1	0.19518253
85	MAP4K1	0.18470305
86	HIPK2	0.17489371
87	CDK2	0.16868490
88	CDC42BPA	0.16342548
89	LYN	0.15842651
90	GSK3B	0.15184123
91	MAPK3	0.14901075
92	MAP2K4	0.14398078
93	PRKCD	0.14371779
94	PRKCA	0.13776878
95	PRKACA	0.13202009
96	MAPK14	0.13134887
97	AKT2	0.13104008
98	AKT3	0.11941302
99	AKT1	0.09331861
100	SMG1	0.08965482

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	7.94731073
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	7.10107929
3	Sulfur relay system_Homo sapiens_hsa04122	4.88014308
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.66482183
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.49902848
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.04254735
7	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.48235614
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.33370709
9	Sphingolipid metabolism_Homo sapiens_hsa00600	2.30823930
10	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.17229250
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94296743
12	Circadian rhythm_Homo sapiens_hsa04710	1.70018601
13	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.61250801
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.47300714
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46375018
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42084365
17	Taste transduction_Homo sapiens_hsa04742	1.32339264
18	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.25212764
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.24468168
20	Other glycan degradation_Homo sapiens_hsa00511	1.08740173
21	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.99276607
22	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.96215377
23	mTOR signaling pathway_Homo sapiens_hsa04150	0.91562351
24	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.90319272
25	Lysine degradation_Homo sapiens_hsa00310	0.90270605
26	Nicotine addiction_Homo sapiens_hsa05033	0.80582110
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77760613
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74187956
29	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73915559
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.73527216
31	Lysosome_Homo sapiens_hsa04142	0.70170171
32	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69094871
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68931982
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68877396
35	Calcium signaling pathway_Homo sapiens_hsa04020	0.68456353
36	Phototransduction_Homo sapiens_hsa04744	0.62565326
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62210241
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62202810
39	Cocaine addiction_Homo sapiens_hsa05030	0.59166713
40	Hippo signaling pathway_Homo sapiens_hsa04390	0.58318244
41	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57419127
42	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.56443299
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54919993
44	Base excision repair_Homo sapiens_hsa03410	0.53866463
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53777223
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52904028
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.51778884
48	Basal cell carcinoma_Homo sapiens_hsa05217	0.48381960
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48182198
50	Melanogenesis_Homo sapiens_hsa04916	0.47692370
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.47021535
52	RNA polymerase_Homo sapiens_hsa03020	0.44387054
53	Insulin resistance_Homo sapiens_hsa04931	0.43606578
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42541989
55	VEGF signaling pathway_Homo sapiens_hsa04370	0.41320201
56	ABC transporters_Homo sapiens_hsa02010	0.41158147
57	Basal transcription factors_Homo sapiens_hsa03022	0.40929953
58	Glutathione metabolism_Homo sapiens_hsa00480	0.40818164
59	Bladder cancer_Homo sapiens_hsa05219	0.40426761
60	Endocytosis_Homo sapiens_hsa04144	0.38208603
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37807539
62	Arginine biosynthesis_Homo sapiens_hsa00220	0.37324764
63	PPAR signaling pathway_Homo sapiens_hsa03320	0.36854573
64	Homologous recombination_Homo sapiens_hsa03440	0.35390340
65	Notch signaling pathway_Homo sapiens_hsa04330	0.35145820
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32041339
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.31606607
68	Axon guidance_Homo sapiens_hsa04360	0.31543149
69	Bile secretion_Homo sapiens_hsa04976	0.31048490
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.27877745
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26628543
72	Metabolic pathways_Homo sapiens_hsa01100	0.26162372
73	Linoleic acid metabolism_Homo sapiens_hsa00591	0.25167863
74	Nitrogen metabolism_Homo sapiens_hsa00910	0.23407196
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.22436666
76	Gap junction_Homo sapiens_hsa04540	0.21940929
77	Cell cycle_Homo sapiens_hsa04110	0.21333751
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.20169019
79	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.19575593
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.17869852
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.16370257
82	Alcoholism_Homo sapiens_hsa05034	0.14450505
83	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.13117619
84	Fatty acid degradation_Homo sapiens_hsa00071	0.13008337
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.12592911
86	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.12407990
87	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.11895545
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.11094337
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.10625415
90	Hepatitis C_Homo sapiens_hsa05160	0.09192004
91	Histidine metabolism_Homo sapiens_hsa00340	0.08989588
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.08914375
93	Mineral absorption_Homo sapiens_hsa04978	0.07978245
94	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.07888773
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.07632495
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.06092359
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.04411510
98	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.04306607
99	Amphetamine addiction_Homo sapiens_hsa05031	0.03614613
100	One carbon pool by folate_Homo sapiens_hsa00670	0.02920068

OR6L2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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