OR6R2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of timing of cell differentiation (GO:0048505)6.95862104
2regulation of development, heterochronic (GO:0040034)6.56100016
3positive regulation of cell fate commitment (GO:0010455)6.54974482
4astrocyte differentiation (GO:0048708)5.41370259
5histone H3-K9 methylation (GO:0051567)5.21695992
6hindbrain development (GO:0030902)5.10013720
7behavioral response to nicotine (GO:0035095)4.88785715
8histone H3-K9 modification (GO:0061647)4.80942073
9dorsal/ventral axis specification (GO:0009950)4.40868950
10positive regulation of neuroblast proliferation (GO:0002052)4.36817876
11pyrimidine nucleobase catabolic process (GO:0006208)4.34099196
12positive regulation of defense response to virus by host (GO:0002230)4.33529549
13platelet dense granule organization (GO:0060155)4.29799456
14regulation of hippo signaling (GO:0035330)4.28884161
15regulation of hexokinase activity (GO:1903299)4.24358547
16regulation of glucokinase activity (GO:0033131)4.24358547
17neural tube formation (GO:0001841)4.23249842
18protein localization to cilium (GO:0061512)4.17502101
19photoreceptor cell development (GO:0042461)4.12957830
20regulation of gene expression by genetic imprinting (GO:0006349)3.93379142
21negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.88904922
22keratinocyte development (GO:0003334)3.88670382
23regulation of transcription involved in cell fate commitment (GO:0060850)3.85456502
24negative regulation of macrophage differentiation (GO:0045650)3.82154220
25kynurenine metabolic process (GO:0070189)3.80520563
26eye photoreceptor cell development (GO:0042462)3.74023629
27gland morphogenesis (GO:0022612)3.55671974
28RNA destabilization (GO:0050779)3.51099566
29glandular epithelial cell development (GO:0002068)3.49624479
30nucleobase catabolic process (GO:0046113)3.46424753
31glandular epithelial cell differentiation (GO:0002067)3.43664640
32negative regulation of thymocyte apoptotic process (GO:0070244)3.43372845
33artery development (GO:0060840)3.42342637
34signal transduction involved in regulation of gene expression (GO:0023019)3.41729155
35regulation of memory T cell differentiation (GO:0043380)3.40409679
36fucose catabolic process (GO:0019317)3.32010981
37L-fucose metabolic process (GO:0042354)3.32010981
38L-fucose catabolic process (GO:0042355)3.32010981
39regulation of cell fate specification (GO:0042659)3.22447070
40cilium morphogenesis (GO:0060271)3.20755850
41pituitary gland development (GO:0021983)3.18986337
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10113872
43neurofilament cytoskeleton organization (GO:0060052)3.08561679
44cellular response to ATP (GO:0071318)3.07493564
45negative regulation of appetite (GO:0032099)3.07246741
46negative regulation of response to food (GO:0032096)3.07246741
47amine catabolic process (GO:0009310)3.02742941
48cellular biogenic amine catabolic process (GO:0042402)3.02742941
49auditory receptor cell stereocilium organization (GO:0060088)2.98007036
50limb bud formation (GO:0060174)2.91723033
51genetic imprinting (GO:0071514)2.89181045
52positive regulation of respiratory burst (GO:0060267)2.88426143
53alanine transport (GO:0032328)2.86910123
54water-soluble vitamin biosynthetic process (GO:0042364)2.85291066
55negative regulation of mast cell activation (GO:0033004)2.83458208
56tryptophan catabolic process (GO:0006569)2.83449323
57indole-containing compound catabolic process (GO:0042436)2.83449323
58indolalkylamine catabolic process (GO:0046218)2.83449323
59cell proliferation in forebrain (GO:0021846)2.81526555
60positive regulation of prostaglandin secretion (GO:0032308)2.77739667
61behavioral response to ethanol (GO:0048149)2.77396198
62negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.76857184
63cellular response to virus (GO:0098586)2.76583730
64regulation of neuroblast proliferation (GO:1902692)2.73859965
65negative regulation of heart rate (GO:0010459)2.71250425
66lens development in camera-type eye (GO:0002088)2.70703744
67cardiac ventricle formation (GO:0003211)2.67340252
68embryonic camera-type eye morphogenesis (GO:0048596)2.64802124
69mucosal-associated lymphoid tissue development (GO:0048537)2.64078787
70Peyers patch development (GO:0048541)2.64078787
71male meiosis I (GO:0007141)2.64065615
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63016096
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63016096
74regulation of interferon-alpha production (GO:0032647)2.62846186
75interferon-gamma production (GO:0032609)2.62576779
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61081626
77photoreceptor cell maintenance (GO:0045494)2.60723973
78transmission of nerve impulse (GO:0019226)2.60415616
79prenylation (GO:0097354)2.58512992
80protein prenylation (GO:0018342)2.58512992
81activated T cell proliferation (GO:0050798)2.57282673
82embryonic epithelial tube formation (GO:0001838)2.56992813
83regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.56688039
84positive regulation of interferon-alpha production (GO:0032727)2.55499373
85urate metabolic process (GO:0046415)2.53668271
86piRNA metabolic process (GO:0034587)2.53359036
87DNA methylation involved in gamete generation (GO:0043046)2.52555877
88mitochondrion degradation (GO:0000422)2.50863524
89smoothened signaling pathway (GO:0007224)2.49484765
90epithelial cilium movement (GO:0003351)2.49061265
91regulation of cell fate commitment (GO:0010453)2.49027710
92DNA deamination (GO:0045006)2.47516214
93indolalkylamine metabolic process (GO:0006586)2.45962917
94retina development in camera-type eye (GO:0060041)2.45591712
95reciprocal meiotic recombination (GO:0007131)2.44274556
96reciprocal DNA recombination (GO:0035825)2.44274556
97regulation of gamma-delta T cell differentiation (GO:0045586)2.42177676
98neuron fate commitment (GO:0048663)2.41796365
99drug catabolic process (GO:0042737)2.41185764
100cornea development in camera-type eye (GO:0061303)11.6629789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.58781726
2IGF1R_20145208_ChIP-Seq_DFB_Human3.48443379
3VDR_22108803_ChIP-Seq_LS180_Human3.40477111
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68450127
5GBX2_23144817_ChIP-Seq_PC3_Human2.58535834
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43825973
7TAF15_26573619_Chip-Seq_HEK293_Human2.36359629
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.19641967
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17990085
10IRF1_19129219_ChIP-ChIP_H3396_Human2.14049117
11NOTCH1_21737748_ChIP-Seq_TLL_Human1.99757600
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97416587
13ER_23166858_ChIP-Seq_MCF-7_Human1.96078800
14P300_19829295_ChIP-Seq_ESCs_Human1.95367630
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93288383
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93254900
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84282774
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.83431228
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81771033
20CBP_20019798_ChIP-Seq_JUKART_Human1.79166759
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79166759
22TP53_22573176_ChIP-Seq_HFKS_Human1.78072890
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74137803
24FUS_26573619_Chip-Seq_HEK293_Human1.74068374
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73965622
26AHR_22903824_ChIP-Seq_MCF-7_Human1.69468512
27EZH2_22144423_ChIP-Seq_EOC_Human1.68961018
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61140510
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57306494
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57282800
31AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56908233
32HTT_18923047_ChIP-ChIP_STHdh_Human1.54168289
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52295984
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50423065
35BCAT_22108803_ChIP-Seq_LS180_Human1.47705317
36STAT3_23295773_ChIP-Seq_U87_Human1.46827036
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46423687
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46052421
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45103365
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45103365
41TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44179502
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42044637
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.41096372
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41079613
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.41079613
46SMAD4_21799915_ChIP-Seq_A2780_Human1.39341486
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.38658980
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.37503845
49RUNX2_22187159_ChIP-Seq_PCA_Human1.37164734
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.36960286
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36922981
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.35997870
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35604510
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.34143224
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33016306
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32408300
57REST_21632747_ChIP-Seq_MESCs_Mouse1.29879195
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28686421
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.28606661
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24807932
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.24726044
62RNF2_27304074_Chip-Seq_NSC_Mouse1.20972340
63TCF4_23295773_ChIP-Seq_U87_Human1.20875218
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18509728
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17918589
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17592114
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17115713
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16804491
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16599812
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15554187
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14586133
72MYC_19829295_ChIP-Seq_ESCs_Human1.13200984
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12804788
74TCF4_22108803_ChIP-Seq_LS180_Human1.12384212
75NANOG_19829295_ChIP-Seq_ESCs_Human1.12071493
76SOX2_19829295_ChIP-Seq_ESCs_Human1.12071493
77AR_25329375_ChIP-Seq_VCAP_Human1.12054244
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.11157423
79NCOR_22424771_ChIP-Seq_293T_Human1.10706295
80EWS_26573619_Chip-Seq_HEK293_Human1.09479308
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09393303
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09097392
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.09011647
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08511931
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.08460725
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.07021018
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06970518
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.06063026
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05993377
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.04213931
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03957611
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03614462
93AR_20517297_ChIP-Seq_VCAP_Human1.02343746
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02182676
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01753554
96MYC_18940864_ChIP-ChIP_HL60_Human1.00735820
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00379288
98JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99193410
99P53_22387025_ChIP-Seq_ESCs_Mouse0.99130925
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98577657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode7.16599391
2MP0005257_abnormal_intraocular_pressure5.89146732
3MP0002638_abnormal_pupillary_reflex5.48607166
4MP0003787_abnormal_imprinting5.19356450
5MP0008877_abnormal_DNA_methylation4.33163046
6MP0008789_abnormal_olfactory_epithelium3.57914699
7MP0002938_white_spotting3.30679212
8MP0005499_abnormal_olfactory_system3.02807321
9MP0005394_taste/olfaction_phenotype3.02807321
10MP0005084_abnormal_gallbladder_morpholo2.57669203
11MP0000383_abnormal_hair_follicle2.56893122
12MP0010678_abnormal_skin_adnexa2.46509816
13MP0003252_abnormal_bile_duct2.20960899
14MP0000613_abnormal_salivary_gland1.97613248
15MP0005410_abnormal_fertilization1.84323775
16MP0002160_abnormal_reproductive_system1.77545702
17MP0003121_genomic_imprinting1.69761785
18MP0002876_abnormal_thyroid_physiology1.67856188
19MP0010234_abnormal_vibrissa_follicle1.67199146
20MP0000427_abnormal_hair_cycle1.59855507
21MP0009046_muscle_twitch1.58731276
22MP0004885_abnormal_endolymph1.45599152
23MP0001919_abnormal_reproductive_system1.45089359
24MP0005389_reproductive_system_phenotype1.42868956
25MP0002928_abnormal_bile_duct1.39702512
26MP0005551_abnormal_eye_electrophysiolog1.39572710
27MP0001324_abnormal_eye_pigmentation1.37984968
28MP0004133_heterotaxia1.36973772
29MP0003878_abnormal_ear_physiology1.29510691
30MP0005377_hearing/vestibular/ear_phenot1.29510691
31MP0003283_abnormal_digestive_organ1.24570208
32MP0002102_abnormal_ear_morphology1.20328907
33MP0006276_abnormal_autonomic_nervous1.17701544
34MP0003880_abnormal_central_pattern1.14790770
35MP0002735_abnormal_chemical_nociception1.12842587
36MP0003724_increased_susceptibility_to1.10063356
37MP0001986_abnormal_taste_sensitivity1.09544162
38MP0005360_urolithiasis1.05156889
39MP0004142_abnormal_muscle_tone1.04780182
40MP0005645_abnormal_hypothalamus_physiol1.03456950
41MP0000778_abnormal_nervous_system1.02522160
42MP0004043_abnormal_pH_regulation0.98864233
43MP0001968_abnormal_touch/_nociception0.98829515
44MP0009745_abnormal_behavioral_response0.98240423
45MP0006072_abnormal_retinal_apoptosis0.93156203
46MP0005174_abnormal_tail_pigmentation0.92849685
47MP0000569_abnormal_digit_pigmentation0.91125790
48MP0001486_abnormal_startle_reflex0.91077743
49MP0002272_abnormal_nervous_system0.89544176
50MP0001501_abnormal_sleep_pattern0.89472225
51MP0002557_abnormal_social/conspecific_i0.89428250
52MP0003195_calcinosis0.88527294
53MP0002064_seizures0.88477789
54MP0005083_abnormal_biliary_tract0.87493144
55MP0005195_abnormal_posterior_eye0.82960329
56MP0005085_abnormal_gallbladder_physiolo0.82593261
57MP0008995_early_reproductive_senescence0.82398151
58MP0005253_abnormal_eye_physiology0.81956584
59MP0002177_abnormal_outer_ear0.80315895
60MP0000647_abnormal_sebaceous_gland0.78235617
61MP0009764_decreased_sensitivity_to0.75364346
62MP0008875_abnormal_xenobiotic_pharmacok0.74451861
63MP0002138_abnormal_hepatobiliary_system0.72641881
64MP0004742_abnormal_vestibular_system0.72106444
65MP0008872_abnormal_physiological_respon0.71897561
66MP0003879_abnormal_hair_cell0.71087741
67MP0005365_abnormal_bile_salt0.69806345
68MP0000631_abnormal_neuroendocrine_gland0.68132775
69MP0010386_abnormal_urinary_bladder0.66630077
70MP0001764_abnormal_homeostasis0.65913699
71MP0000428_abnormal_craniofacial_morphol0.65359651
72MP0002752_abnormal_somatic_nervous0.64560852
73MP0002736_abnormal_nociception_after0.63538571
74MP0005386_behavior/neurological_phenoty0.63218199
75MP0004924_abnormal_behavior0.63218199
76MP0002229_neurodegeneration0.62518845
77MP0002653_abnormal_ependyma_morphology0.62103051
78MP0005197_abnormal_uvea_morphology0.62088793
79MP0000015_abnormal_ear_pigmentation0.60660695
80MP0001970_abnormal_pain_threshold0.60295101
81MP0002277_abnormal_respiratory_mucosa0.58950740
82MP0001944_abnormal_pancreas_morphology0.58950730
83MP0002572_abnormal_emotion/affect_behav0.58527309
84MP0002733_abnormal_thermal_nociception0.56542361
85MP0001529_abnormal_vocalization0.55972491
86MP0003633_abnormal_nervous_system0.55874462
87MP0001963_abnormal_hearing_physiology0.54908551
88MP0002693_abnormal_pancreas_physiology0.54641604
89MP0002148_abnormal_hypersensitivity_rea0.53996907
90MP0002063_abnormal_learning/memory/cond0.53795669
91MP0002234_abnormal_pharynx_morphology0.53008458
92MP0005391_vision/eye_phenotype0.52270094
93MP0000470_abnormal_stomach_morphology0.50398837
94MP0003698_abnormal_male_reproductive0.50007390
95MP0001485_abnormal_pinna_reflex0.49496450
96MP0001186_pigmentation_phenotype0.49349564
97MP0005646_abnormal_pituitary_gland0.49059830
98MP0003011_delayed_dark_adaptation0.48970489
99MP0002098_abnormal_vibrissa_morphology0.48963124
100MP0000955_abnormal_spinal_cord0.47576794

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)7.66126382
2Hypoplasia of the fovea (HP:0007750)7.66126382
3Abnormality of the fovea (HP:0000493)6.17973857
4Aplasia/Hypoplasia of the macula (HP:0008059)4.93531270
5Optic nerve hypoplasia (HP:0000609)4.60630991
6Aplasia/Hypoplasia affecting the retina (HP:0008061)4.59219863
7Aplasia/Hypoplasia of the optic nerve (HP:0008058)4.24846446
8Optic nerve coloboma (HP:0000588)4.02568798
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.91255381
10Nephronophthisis (HP:0000090)3.51671871
11Pancreatic cysts (HP:0001737)3.44215513
12True hermaphroditism (HP:0010459)3.37527996
13Molar tooth sign on MRI (HP:0002419)3.27552284
14Abnormality of midbrain morphology (HP:0002418)3.27552284
15Pancreatic fibrosis (HP:0100732)3.26905126
16Pendular nystagmus (HP:0012043)3.20511131
17Keratitis (HP:0000491)3.01352983
18Intestinal atresia (HP:0011100)2.93603098
19Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.87521747
20Chronic hepatic failure (HP:0100626)2.87268655
21Hip dysplasia (HP:0001385)2.78845764
22Abnormality of the renal medulla (HP:0100957)2.76909165
23Abolished electroretinogram (ERG) (HP:0000550)2.69401172
24Difficulty running (HP:0009046)2.65101717
25Type II lissencephaly (HP:0007260)2.63916795
26Attenuation of retinal blood vessels (HP:0007843)2.63330606
27Abnormality of the renal cortex (HP:0011035)2.61247281
28Congenital stationary night blindness (HP:0007642)2.60324762
29Abnormal rod and cone electroretinograms (HP:0008323)2.58116757
30Decreased central vision (HP:0007663)2.55873916
31Abnormality of lateral ventricle (HP:0030047)2.52985348
32Congenital glaucoma (HP:0001087)2.51010669
33Stomatitis (HP:0010280)2.46490066
34Congenital sensorineural hearing impairment (HP:0008527)2.42618834
35Inability to walk (HP:0002540)2.42322378
36Polydipsia (HP:0001959)2.35509992
37Abnormal drinking behavior (HP:0030082)2.35509992
38Lissencephaly (HP:0001339)2.35212056
39Thyroid-stimulating hormone excess (HP:0002925)2.31503901
40Broad-based gait (HP:0002136)2.30438839
41Abnormality of the aortic arch (HP:0012303)2.28684211
42Albinism (HP:0001022)2.23352012
43Increased corneal curvature (HP:0100692)2.22625270
44Keratoconus (HP:0000563)2.22625270
45Cerebellar dysplasia (HP:0007033)2.18099603
46Protruding tongue (HP:0010808)2.14436116
47Bile duct proliferation (HP:0001408)2.13798289
48Abnormal biliary tract physiology (HP:0012439)2.13798289
49Progressive inability to walk (HP:0002505)2.13605169
50Aplasia/Hypoplasia of the lens (HP:0008063)2.06063429
51Cystic liver disease (HP:0006706)2.03459373
52Hyperventilation (HP:0002883)2.03128636
53Tubular atrophy (HP:0000092)2.02392487
54Abnormality of the labia minora (HP:0012880)2.01146071
55Hip contracture (HP:0003273)2.00863728
56Thyroiditis (HP:0100646)1.99601968
57Pachygyria (HP:0001302)1.98334671
58Severe combined immunodeficiency (HP:0004430)1.97535384
59Methylmalonic acidemia (HP:0002912)1.97099703
60Sclerocornea (HP:0000647)1.96109619
61Mask-like facies (HP:0000298)1.95171405
62Tetraplegia (HP:0002445)1.92823919
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.91603554
64Growth hormone deficiency (HP:0000824)1.88843194
65Abnormality of alanine metabolism (HP:0010916)1.87752363
66Hyperalaninemia (HP:0003348)1.87752363
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87752363
68Polyuria (HP:0000103)1.85854214
69Renal cortical cysts (HP:0000803)1.85022132
70Methylmalonic aciduria (HP:0012120)1.84589375
71Stomach cancer (HP:0012126)1.83444225
72Bony spicule pigmentary retinopathy (HP:0007737)1.82411835
73Retrobulbar optic neuritis (HP:0100654)1.81319529
74Optic neuritis (HP:0100653)1.81319529
75Gaze-evoked nystagmus (HP:0000640)1.80962818
76Occipital encephalocele (HP:0002085)1.78804393
77Hematochezia (HP:0002573)1.77737529
78Congenital malformation of the right heart (HP:0011723)1.74469868
79Double outlet right ventricle (HP:0001719)1.74469868
80Retinal atrophy (HP:0001105)1.73472335
81Polyphagia (HP:0002591)1.72466367
82Vacuolated lymphocytes (HP:0001922)1.68096908
83Mutism (HP:0002300)1.66609229
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.66499733
85Esophageal neoplasm (HP:0100751)1.63407793
86Neoplasm of head and neck (HP:0012288)1.63407793
87Abnormality of dental color (HP:0011073)1.62687442
88Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62495894
89Hypoplasia of the brainstem (HP:0002365)1.62495894
90Medial flaring of the eyebrow (HP:0010747)1.62444595
91Adrenal hypoplasia (HP:0000835)1.61261170
92Agitation (HP:0000713)1.60248292
93Disproportionate short-trunk short stature (HP:0003521)1.60212243
94Oligodactyly (hands) (HP:0001180)1.58811947
95Gastrointestinal atresia (HP:0002589)1.58528993
96Absent speech (HP:0001344)1.58254290
97Anencephaly (HP:0002323)1.57590576
98Aplasia/hypoplasia of the uterus (HP:0008684)1.56566713
99Short tibia (HP:0005736)1.55136400
100Dandy-Walker malformation (HP:0001305)1.53258912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.06784977
2MAPK133.76590480
3PTK2B3.64854922
4ADRBK23.23966621
5FRK3.18915644
6MAP4K23.05737867
7INSRR2.78320853
8WNK32.63132981
9ZAK2.39351138
10GRK12.29649885
11HIPK22.21878238
12MAP3K142.17805567
13STK392.09339767
14TAOK32.06248289
15PINK12.01591177
16OXSR12.01366938
17BCKDK1.87770707
18TXK1.80032544
19PDK21.77635915
20STK161.74963206
21CDK191.67174692
22MAP3K41.58627733
23TNK21.55811454
24MARK11.54338192
25BMPR1B1.33246767
26TEC1.30962346
27TLK11.29285079
28MAP2K71.25680468
29FES1.23330544
30PAK61.22958174
31TYRO31.21152919
32NUAK11.15014516
33FLT31.13617888
34NTRK31.12780539
35BCR1.12037362
36GRK61.02797073
37ARAF1.00625002
38YES10.98343873
39IRAK20.89438702
40PAK30.89041661
41SIK20.85349795
42EIF2AK30.84723239
43ADRBK10.80840337
44WNK10.76037967
45PIM20.75570039
46PRKCG0.72296431
47CSNK1G30.71515795
48CSNK1G20.70997466
49DAPK20.70434025
50PRKCE0.70273728
51PDK10.66428585
52GRK70.66293042
53PRKCZ0.66266386
54TNIK0.63977353
55MAP3K130.58952071
56WEE10.58394354
57DYRK1A0.57292055
58CSNK1G10.56917543
59DYRK20.56246951
60PLK20.55251237
61CASK0.53656598
62MAP2K40.52433927
63KIT0.51522782
64MAPK70.51266265
65SYK0.51044646
66PDPK10.50521195
67MAP2K20.47631773
68PRKCQ0.46785280
69PRKCH0.46393619
70MKNK20.46382169
71CSNK1A10.42967933
72JAK20.41918229
73CSNK1A1L0.41801880
74ITK0.40713756
75MAP2K10.40028263
76EPHA40.38333108
77CAMKK10.36220065
78RAF10.36196426
79PRKACA0.34844645
80MKNK10.33738231
81PRKCI0.33000661
82GRK50.32891590
83CSK0.31362471
84MINK10.30700398
85LYN0.29961154
86PRKCA0.29475977
87DYRK30.29182114
88CAMK2A0.27831324
89JAK30.26716811
90CSNK1D0.26363828
91PIK3CA0.26360410
92IKBKE0.25744017
93PHKG20.25718864
94PHKG10.25718864
95ABL10.25400732
96RPS6KB10.24564204
97NEK90.24245520
98RPS6KA50.23552358
99FGFR20.22736006
100PRKG20.21758446

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.75209526
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.04809572
3Caffeine metabolism_Homo sapiens_hsa002323.03173742
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.98437264
5Nitrogen metabolism_Homo sapiens_hsa009102.57147553
6Phototransduction_Homo sapiens_hsa047442.51027530
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30965400
8Linoleic acid metabolism_Homo sapiens_hsa005912.27422444
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07459871
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04746035
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02029967
12Butanoate metabolism_Homo sapiens_hsa006501.91932492
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90959012
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78486196
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68968241
16Basal transcription factors_Homo sapiens_hsa030221.65564792
17Olfactory transduction_Homo sapiens_hsa047401.62971951
18Homologous recombination_Homo sapiens_hsa034401.58244401
19Nicotine addiction_Homo sapiens_hsa050331.55035778
20Peroxisome_Homo sapiens_hsa041461.53485527
21Collecting duct acid secretion_Homo sapiens_hsa049661.52391557
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.48746594
23Steroid biosynthesis_Homo sapiens_hsa001001.46423555
24Other glycan degradation_Homo sapiens_hsa005111.43815091
25Pentose phosphate pathway_Homo sapiens_hsa000301.41020825
26Ether lipid metabolism_Homo sapiens_hsa005651.37726380
27Tryptophan metabolism_Homo sapiens_hsa003801.36754122
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.35119182
29Arachidonic acid metabolism_Homo sapiens_hsa005901.34827940
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31857004
31Morphine addiction_Homo sapiens_hsa050321.29608782
32Ovarian steroidogenesis_Homo sapiens_hsa049131.29227679
33Oxidative phosphorylation_Homo sapiens_hsa001901.25795411
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24230909
35ABC transporters_Homo sapiens_hsa020101.19780207
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14907095
37Circadian entrainment_Homo sapiens_hsa047131.13670648
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12882084
39Serotonergic synapse_Homo sapiens_hsa047261.11194803
40Fanconi anemia pathway_Homo sapiens_hsa034601.04622823
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01843826
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99406616
43Circadian rhythm_Homo sapiens_hsa047100.99247205
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99146116
45Staphylococcus aureus infection_Homo sapiens_hsa051500.95357601
46Glycerolipid metabolism_Homo sapiens_hsa005610.91605325
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89256711
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88424387
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87658489
50Asthma_Homo sapiens_hsa053100.86452850
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86127110
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.85479739
53Vitamin digestion and absorption_Homo sapiens_hsa049770.84247889
54RNA degradation_Homo sapiens_hsa030180.84066631
55Chemical carcinogenesis_Homo sapiens_hsa052040.82168499
56Glutamatergic synapse_Homo sapiens_hsa047240.79494898
57GABAergic synapse_Homo sapiens_hsa047270.79474992
58Taste transduction_Homo sapiens_hsa047420.78824753
59Insulin secretion_Homo sapiens_hsa049110.78693816
60beta-Alanine metabolism_Homo sapiens_hsa004100.77318504
61Rheumatoid arthritis_Homo sapiens_hsa053230.76965256
62Retinol metabolism_Homo sapiens_hsa008300.76486454
63Parkinsons disease_Homo sapiens_hsa050120.74532173
64Fat digestion and absorption_Homo sapiens_hsa049750.73084915
65Selenocompound metabolism_Homo sapiens_hsa004500.72584704
66Alzheimers disease_Homo sapiens_hsa050100.72036786
67Salivary secretion_Homo sapiens_hsa049700.71009896
68Protein export_Homo sapiens_hsa030600.70997301
69Long-term depression_Homo sapiens_hsa047300.70238831
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67151815
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66914112
72Arginine and proline metabolism_Homo sapiens_hsa003300.57879559
73Regulation of autophagy_Homo sapiens_hsa041400.57122536
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56396893
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55053935
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53912029
77Calcium signaling pathway_Homo sapiens_hsa040200.46551976
78Primary immunodeficiency_Homo sapiens_hsa053400.46157116
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44653603
80Metabolic pathways_Homo sapiens_hsa011000.44395595
81Cardiac muscle contraction_Homo sapiens_hsa042600.43155322
82Gastric acid secretion_Homo sapiens_hsa049710.39900884
83Vitamin B6 metabolism_Homo sapiens_hsa007500.39555508
84Type II diabetes mellitus_Homo sapiens_hsa049300.37751698
85Phagosome_Homo sapiens_hsa041450.37668123
86Cholinergic synapse_Homo sapiens_hsa047250.37554285
87Type I diabetes mellitus_Homo sapiens_hsa049400.37094960
88African trypanosomiasis_Homo sapiens_hsa051430.35496568
89Huntingtons disease_Homo sapiens_hsa050160.34182030
90Hematopoietic cell lineage_Homo sapiens_hsa046400.32985343
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32767720
92Lysosome_Homo sapiens_hsa041420.30923131
93Allograft rejection_Homo sapiens_hsa053300.30517521
94Pyrimidine metabolism_Homo sapiens_hsa002400.30483198
95Chemokine signaling pathway_Homo sapiens_hsa040620.29899242
96Axon guidance_Homo sapiens_hsa043600.29483598
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29252913
98Tuberculosis_Homo sapiens_hsa051520.28304761
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27983010
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27124501

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