OR6W1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)9.99879243
2regulation of dopamine secretion (GO:0014059)8.79501285
3determination of adult lifespan (GO:0008340)8.59099263
4phosphatidylinositol acyl-chain remodeling (GO:0036149)7.34472801
5phosphatidylserine acyl-chain remodeling (GO:0036150)7.10095903
6phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.67735553
7alkaloid metabolic process (GO:0009820)6.64019087
8regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)6.37529337
9phosphatidylethanolamine acyl-chain remodeling (GO:0036152)6.21345360
10cullin deneddylation (GO:0010388)6.19558722
11neuron remodeling (GO:0016322)5.89189492
12phosphatidylcholine acyl-chain remodeling (GO:0036151)5.57926360
13chaperone-mediated protein complex assembly (GO:0051131)5.52268182
14protein import into peroxisome matrix (GO:0016558)5.44670721
15protein deneddylation (GO:0000338)5.34816583
16positive regulation of microtubule polymerization or depolymerization (GO:0031112)4.97237677
17cAMP-mediated signaling (GO:0019933)4.82630275
18regulation of actin nucleation (GO:0051125)4.72852921
19phosphatidic acid metabolic process (GO:0046473)4.68041458
20phosphatidic acid biosynthetic process (GO:0006654)4.68041458
21dopamine transport (GO:0015872)4.67116076
22mating behavior (GO:0007617)4.51235839
23regulation of catecholamine secretion (GO:0050433)4.42456045
24positive regulation of microtubule polymerization (GO:0031116)4.40744826
25peristalsis (GO:0030432)4.36419536
26dopamine biosynthetic process (GO:0042416)4.29735265
27termination of G-protein coupled receptor signaling pathway (GO:0038032)4.18087019
28activation of adenylate cyclase activity (GO:0007190)4.11935693
29phosphatidylserine metabolic process (GO:0006658)4.06815426
30microtubule depolymerization (GO:0007019)4.04224340
31tyrosine metabolic process (GO:0006570)4.03978666
32neurotransmitter-gated ion channel clustering (GO:0072578)3.93609509
33phenol-containing compound catabolic process (GO:0019336)3.88844469
34toxin metabolic process (GO:0009404)3.84710497
35regulation of microtubule polymerization (GO:0031113)3.84657411
36adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.78816674
37retinal cone cell development (GO:0046549)3.78141145
38bile acid and bile salt transport (GO:0015721)3.74976901
39response to redox state (GO:0051775)3.74901546
40termination of signal transduction (GO:0023021)3.71970376
41positive regulation of multicellular organism growth (GO:0040018)3.62135199
42negative regulation of microtubule polymerization (GO:0031115)3.61458542
43synaptic transmission, dopaminergic (GO:0001963)3.61191609
44phosphatidylglycerol metabolic process (GO:0046471)3.57818414
45positive regulation of adenylate cyclase activity (GO:0045762)3.57383367
46cell morphogenesis involved in neuron differentiation (GO:0048667)3.54239211
47negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.51433363
48cyclic-nucleotide-mediated signaling (GO:0019935)3.49861062
49lipopolysaccharide biosynthetic process (GO:0009103)3.49751513
50nonmotile primary cilium assembly (GO:0035058)3.43607736
51sulfation (GO:0051923)3.41642884
52behavioral response to nicotine (GO:0035095)3.40808665
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33144155
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.33144155
55NADH dehydrogenase complex assembly (GO:0010257)3.33144155
56microtubule polymerization or depolymerization (GO:0031109)3.28660816
57water-soluble vitamin biosynthetic process (GO:0042364)3.26165682
58protein complex biogenesis (GO:0070271)3.25815225
59succinate metabolic process (GO:0006105)3.23405455
60male meiosis (GO:0007140)3.20360983
61protein localization to peroxisome (GO:0072662)3.12872407
62protein targeting to peroxisome (GO:0006625)3.12872407
63establishment of protein localization to peroxisome (GO:0072663)3.12872407
64positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.09381225
65drug catabolic process (GO:0042737)3.08380809
66regulation of amine transport (GO:0051952)3.06357978
67dopamine metabolic process (GO:0042417)3.03450166
68activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.03435501
69alditol phosphate metabolic process (GO:0052646)2.98909463
70regulation of catecholamine metabolic process (GO:0042069)2.97762746
71regulation of dopamine metabolic process (GO:0042053)2.97762746
72mitotic cell cycle arrest (GO:0071850)2.95834711
73somite rostral/caudal axis specification (GO:0032525)2.95731106
74urinary tract smooth muscle contraction (GO:0014848)2.94987765
75lipopolysaccharide metabolic process (GO:0008653)2.92428558
76mitochondrial respiratory chain complex assembly (GO:0033108)2.89173412
77positive regulation of cyclase activity (GO:0031281)2.89072913
78catechol-containing compound biosynthetic process (GO:0009713)2.85873743
79catecholamine biosynthetic process (GO:0042423)2.85873743
80DNA replication-dependent nucleosome organization (GO:0034723)2.85617231
81DNA replication-dependent nucleosome assembly (GO:0006335)2.85617231
82neurotransmitter biosynthetic process (GO:0042136)2.84745892
83negative regulation of cell aging (GO:0090344)2.84532245
84negative regulation of activin receptor signaling pathway (GO:0032926)2.84381603
85cellular response to nicotine (GO:0071316)2.84006030
86response to insecticide (GO:0017085)2.81469421
87basic amino acid transport (GO:0015802)2.80038592
88peroxisomal transport (GO:0043574)2.79797341
89positive regulation of cAMP biosynthetic process (GO:0030819)2.78050933
902-oxoglutarate metabolic process (GO:0006103)2.76641695
91cardiovascular system development (GO:0072358)2.75810401
92neuronal action potential (GO:0019228)2.75529714
93glomerular visceral epithelial cell development (GO:0072015)2.71289306
94fatty acid elongation (GO:0030497)2.69975767
95negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.69552844
96positive regulation of lyase activity (GO:0051349)2.68609292
97cAMP catabolic process (GO:0006198)2.68589867
98positive regulation of growth hormone secretion (GO:0060124)13.7129987
99growth hormone secretion (GO:0030252)11.9745692
100regulation of growth hormone secretion (GO:0060123)10.0122232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.48534020
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse6.38935443
3GATA1_22025678_ChIP-Seq_K562_Human4.20001050
4VDR_22108803_ChIP-Seq_LS180_Human4.02937765
5ZNF274_21170338_ChIP-Seq_K562_Hela3.96121269
6GBX2_23144817_ChIP-Seq_PC3_Human3.89211506
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.37774102
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.26844388
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.94599552
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.84463667
11TP53_16413492_ChIP-PET_HCT116_Human2.83540372
12DROSHA_22980978_ChIP-Seq_HELA_Human2.69552875
13TP53_22573176_ChIP-Seq_HFKS_Human2.19406716
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01237004
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95496892
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.77122581
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65730998
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57619528
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57614639
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57544322
21GATA3_21878914_ChIP-Seq_MCF-7_Human1.54831085
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54695058
23ER_23166858_ChIP-Seq_MCF-7_Human1.52530081
24* MYC_19829295_ChIP-Seq_ESCs_Human1.47351553
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42143426
26PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37825412
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.33293854
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32743420
29EZH2_22144423_ChIP-Seq_EOC_Human1.32448269
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30775051
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.30384185
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.28253310
33ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26481056
34BCAT_22108803_ChIP-Seq_LS180_Human1.25491665
35EGR1_19032775_ChIP-ChIP_M12_Human1.25275653
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22511993
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.22329591
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22329591
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21839649
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.19836313
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18678842
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.18267110
43EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.17840110
44RXR_22108803_ChIP-Seq_LS180_Human1.17413542
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15637014
46FOXH1_21741376_ChIP-Seq_EPCs_Human1.13786737
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13761211
48FOXH1_21741376_ChIP-Seq_ESCs_Human1.13536405
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13381392
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13066279
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11539063
52REST_21632747_ChIP-Seq_MESCs_Mouse1.10305185
53* STAT3_23295773_ChIP-Seq_U87_Human1.09280366
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07453027
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.06691158
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06098941
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05494733
58SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04889676
59* P300_19829295_ChIP-Seq_ESCs_Human1.04646491
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04354109
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03185603
62NANOG_19829295_ChIP-Seq_ESCs_Human1.03112712
63SOX2_19829295_ChIP-Seq_ESCs_Human1.03112712
64ERA_21632823_ChIP-Seq_H3396_Human1.02529555
65TCF4_23295773_ChIP-Seq_U87_Human0.99973334
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99403587
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99129284
68BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99068714
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98703695
70CJUN_26792858_Chip-Seq_BT549_Human0.98555797
71CRX_20693478_ChIP-Seq_RETINA_Mouse0.98246318
72REST_18959480_ChIP-ChIP_MESCs_Mouse0.97983202
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97719736
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97719736
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97519035
76MYC_18940864_ChIP-ChIP_HL60_Human0.96566413
77EED_16625203_ChIP-ChIP_MESCs_Mouse0.95864805
78CBX2_27304074_Chip-Seq_ESCs_Mouse0.94776748
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93199474
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93185572
81SMAD4_21799915_ChIP-Seq_A2780_Human0.92272427
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.91735948
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90199671
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89857094
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89726999
86MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89187680
87* OCT4_20526341_ChIP-Seq_ESCs_Human0.88889393
88ESET_19884257_ChIP-Seq_ESCs_Mouse0.88448767
89SMRT_27268052_Chip-Seq_Bcells_Human0.88096437
90TCF4_22108803_ChIP-Seq_LS180_Human0.87948317
91* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87879686
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86855917
93AR_25329375_ChIP-Seq_VCAP_Human0.86673834
94NCOR_22424771_ChIP-Seq_293T_Human0.86467978
95AHR_22903824_ChIP-Seq_MCF-7_Human0.85895824
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84507122
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83217467
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82670833
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82556374
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81474533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001501_abnormal_sleep_pattern6.66132434
2MP0002653_abnormal_ependyma_morphology5.31969560
3MP0002102_abnormal_ear_morphology4.65623527
4MP0005551_abnormal_eye_electrophysiolog4.19642201
5MP0000569_abnormal_digit_pigmentation4.07922281
6MP0003950_abnormal_plasma_membrane3.47390659
7MP0008877_abnormal_DNA_methylation3.03277120
8MP0001529_abnormal_vocalization3.00868079
9MP0003283_abnormal_digestive_organ2.90101815
10MP0001881_abnormal_mammary_gland2.72004375
11MP0000566_synostosis2.58307495
12MP0003959_abnormal_lean_body2.51044117
13MP0008875_abnormal_xenobiotic_pharmacok2.19960987
14MP0000631_abnormal_neuroendocrine_gland2.11932058
15MP0004924_abnormal_behavior1.95633599
16MP0005386_behavior/neurological_phenoty1.95633599
17MP0005365_abnormal_bile_salt1.85129913
18MP0005266_abnormal_metabolism1.71373551
19MP0008789_abnormal_olfactory_epithelium1.63881322
20MP0004381_abnormal_hair_follicle1.59770204
21MP0001905_abnormal_dopamine_level1.52904187
22MP0009046_muscle_twitch1.48258509
23MP0002272_abnormal_nervous_system1.44761320
24MP0000026_abnormal_inner_ear1.38940376
25MP0001485_abnormal_pinna_reflex1.35301332
26MP0001968_abnormal_touch/_nociception1.34598793
27MP0003567_abnormal_fetal_cardiomyocyte1.34051974
28MP0001986_abnormal_taste_sensitivity1.30788843
29MP0000383_abnormal_hair_follicle1.30015949
30MP0010386_abnormal_urinary_bladder1.25434234
31MP0002572_abnormal_emotion/affect_behav1.24607106
32MP0006035_abnormal_mitochondrial_morpho1.23855481
33MP0002557_abnormal_social/conspecific_i1.22971245
34MP0002332_abnormal_exercise_endurance1.19434693
35MP0001177_atelectasis1.16282853
36MP0005394_taste/olfaction_phenotype1.15460541
37MP0005499_abnormal_olfactory_system1.15460541
38MP0005195_abnormal_posterior_eye1.14812887
39MP0001963_abnormal_hearing_physiology1.14463125
40MP0000579_abnormal_nail_morphology1.12529822
41MP0005253_abnormal_eye_physiology1.11171966
42MP0005164_abnormal_response_to1.10334139
43MP0003136_yellow_coat_color1.09843296
44MP0002229_neurodegeneration1.09726418
45MP0002736_abnormal_nociception_after1.07621611
46MP0006036_abnormal_mitochondrial_physio1.07606428
47MP0008872_abnormal_physiological_respon1.05989011
48MP0002067_abnormal_sensory_capabilities1.04905545
49MP0004043_abnormal_pH_regulation1.04751233
50MP0005376_homeostasis/metabolism_phenot1.02590644
51MP0005171_absent_coat_pigmentation1.02387120
52MP0003195_calcinosis1.01795247
53MP0004142_abnormal_muscle_tone1.01008395
54MP0003937_abnormal_limbs/digits/tail_de1.00027879
55MP0002876_abnormal_thyroid_physiology0.97757494
56MP0003632_abnormal_nervous_system0.96874284
57MP0002148_abnormal_hypersensitivity_rea0.95731936
58MP0009764_decreased_sensitivity_to0.95099551
59MP0002111_abnormal_tail_morphology0.92975846
60MP0000751_myopathy0.92252674
61MP0003119_abnormal_digestive_system0.87810347
62MP0000639_abnormal_adrenal_gland0.87211155
63MP0000538_abnormal_urinary_bladder0.86030999
64MP0005084_abnormal_gallbladder_morpholo0.85574646
65MP0004134_abnormal_chest_morphology0.85360706
66MP0005332_abnormal_amino_acid0.84600036
67MP0004133_heterotaxia0.83310426
68MP0009745_abnormal_behavioral_response0.82848062
69MP0002751_abnormal_autonomic_nervous0.80616116
70MP0003122_maternal_imprinting0.79563572
71MP0001486_abnormal_startle_reflex0.78765493
72MP0005220_abnormal_exocrine_pancreas0.78282866
73MP0002139_abnormal_hepatobiliary_system0.78206456
74MP0000470_abnormal_stomach_morphology0.78169323
75MP0001984_abnormal_olfaction0.77958304
76MP0003698_abnormal_male_reproductive0.76798664
77MP0004742_abnormal_vestibular_system0.76094094
78MP0000049_abnormal_middle_ear0.75231091
79MP0005360_urolithiasis0.74981503
80MP0003329_amyloid_beta_deposits0.74292366
81MP0002752_abnormal_somatic_nervous0.71363993
82MP0002152_abnormal_brain_morphology0.71272741
83MP0002837_dystrophic_cardiac_calcinosis0.69889425
84MP0002938_white_spotting0.69144833
85MP0000647_abnormal_sebaceous_gland0.67569452
86MP0002063_abnormal_learning/memory/cond0.66796368
87MP0000685_abnormal_immune_system0.65232217
88MP0004085_abnormal_heartbeat0.64411959
89MP0008775_abnormal_heart_ventricle0.63025137
90MP0002064_seizures0.60703601
91MP0002882_abnormal_neuron_morphology0.59480146
92MP0004147_increased_porphyrin_level0.59342236
93MP0004885_abnormal_endolymph0.57827264
94MP0002233_abnormal_nose_morphology0.57609120
95MP0002069_abnormal_eating/drinking_beha0.56443492
96MP0002109_abnormal_limb_morphology0.55545955
97MP0001929_abnormal_gametogenesis0.55514160
98MP0000230_abnormal_systemic_arterial0.55187638
99MP0010329_abnormal_lipoprotein_level0.54982152
100MP0002115_abnormal_skeleton_extremities0.53999511

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)7.02842150
2Congenital stationary night blindness (HP:0007642)6.94779042
3Limb dystonia (HP:0002451)6.32340266
4Oligodactyly (hands) (HP:0001180)4.63483119
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.63139491
6Renal cortical cysts (HP:0000803)4.42151359
7Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.13664996
8Global brain atrophy (HP:0002283)4.02651146
93-Methylglutaconic aciduria (HP:0003535)3.98067036
10Microvesicular hepatic steatosis (HP:0001414)3.81668514
11Concave nail (HP:0001598)3.77531922
12Abnormality of the renal cortex (HP:0011035)3.76521198
13Gait imbalance (HP:0002141)3.63005812
14Growth hormone deficiency (HP:0000824)3.60562237
15Decreased electroretinogram (ERG) amplitude (HP:0000654)3.59296341
16Fibular hypoplasia (HP:0003038)3.46838528
17Tubular atrophy (HP:0000092)3.45593036
18Protruding tongue (HP:0010808)3.43161608
19Methylmalonic aciduria (HP:0012120)3.32385035
20Abnormality of the 4th metacarpal (HP:0010012)3.29925765
21Brushfield spots (HP:0001088)3.26953876
22Congenital primary aphakia (HP:0007707)3.26122898
23Medial flaring of the eyebrow (HP:0010747)3.15627832
24Turricephaly (HP:0000262)3.03264921
25Oligodactyly (HP:0012165)3.00529642
26Pancreatic cysts (HP:0001737)2.98566116
27Nephrogenic diabetes insipidus (HP:0009806)2.97071020
28Hyperalaninemia (HP:0003348)2.89988077
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.89988077
30Abnormality of alanine metabolism (HP:0010916)2.89988077
31Spastic tetraparesis (HP:0001285)2.88545935
32Widely patent fontanelles and sutures (HP:0004492)2.86244891
33Congenital, generalized hypertrichosis (HP:0004540)2.84264096
34Prolonged neonatal jaundice (HP:0006579)2.81690861
35Cheilitis (HP:0100825)2.81414123
36Lipid accumulation in hepatocytes (HP:0006561)2.80829867
37Nephronophthisis (HP:0000090)2.76823519
38Bile duct proliferation (HP:0001408)2.73665429
39Abnormal biliary tract physiology (HP:0012439)2.73665429
40Testicular atrophy (HP:0000029)2.73307392
41Morphological abnormality of the pyramidal tract (HP:0002062)2.70413027
42Breech presentation (HP:0001623)2.67359883
43Long nose (HP:0003189)2.66786108
44Furrowed tongue (HP:0000221)2.63288247
45Abnormal number of erythroid precursors (HP:0012131)2.63257867
46Flat occiput (HP:0005469)2.62496465
47Bell-shaped thorax (HP:0001591)2.62456406
48Adrenal hypoplasia (HP:0000835)2.60750397
49Progressive inability to walk (HP:0002505)2.57941277
50Dicarboxylic aciduria (HP:0003215)2.57642111
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57642111
52Intellectual disability, progressive (HP:0006887)2.55085991
53Pigmentary retinal degeneration (HP:0001146)2.54891841
54Chorioretinal atrophy (HP:0000533)2.47551892
55Partial agenesis of the corpus callosum (HP:0001338)2.44764477
56Pancreatic fibrosis (HP:0100732)2.42827926
57Enlarged kidneys (HP:0000105)2.41988544
58Attenuation of retinal blood vessels (HP:0007843)2.37890816
59Molar tooth sign on MRI (HP:0002419)2.35684850
60Abnormality of midbrain morphology (HP:0002418)2.35684850
61Dyschromatopsia (HP:0007641)2.34180836
62Poor coordination (HP:0002370)2.34020504
63Abnormality of cells of the erythroid lineage (HP:0012130)2.33734574
64Abnormality of fatty-acid metabolism (HP:0004359)2.29291730
65Vaginal atresia (HP:0000148)2.24738749
66True hermaphroditism (HP:0010459)2.20618231
67Aplasia/Hypoplasia of the fibula (HP:0006492)2.18961228
68Retinal atrophy (HP:0001105)2.18856271
69Genital tract atresia (HP:0001827)2.17953401
70Abnormality of the renal medulla (HP:0100957)2.16211529
71Intellectual disability, severe (HP:0010864)2.15540170
72Macroglossia (HP:0000158)2.14976763
73Clitoromegaly (HP:0000057)2.14050967
74Congenital sensorineural hearing impairment (HP:0008527)2.13044503
75Inability to walk (HP:0002540)2.12261553
76Anophthalmia (HP:0000528)2.12189280
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10673300
78Unsteady gait (HP:0002317)2.07973644
79Prominent supraorbital ridges (HP:0000336)2.04114946
80Chronic hepatic failure (HP:0100626)2.00120523
81Left ventricular hypertrophy (HP:0001712)1.96374186
82Decreased central vision (HP:0007663)1.95774742
83Postaxial foot polydactyly (HP:0001830)1.95465097
84Anencephaly (HP:0002323)1.94996472
85Mesangial abnormality (HP:0001966)1.93832722
86Clumsiness (HP:0002312)1.92693927
87Rib fusion (HP:0000902)1.91939557
88Amelogenesis imperfecta (HP:0000705)1.90014078
89Large for gestational age (HP:0001520)1.87407014
90Tachypnea (HP:0002789)1.84481954
91Limb hypertonia (HP:0002509)1.83776977
92Hypokinesia (HP:0002375)1.81725697
93Posterior embryotoxon (HP:0000627)1.81190481
94Metatarsus adductus (HP:0001840)1.80795844
95Acute lymphatic leukemia (HP:0006721)1.79759928
96Prolonged QT interval (HP:0001657)1.79090426
97Progressive microcephaly (HP:0000253)1.76763453
98Decreased testicular size (HP:0008734)1.76450647
99Febrile seizures (HP:0002373)1.76169722
100Hyperglycinuria (HP:0003108)1.75452525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K26.07166122
2MAPKAPK53.53055522
3NME13.44693206
4MAPK133.34221379
5NEK92.96611350
6PKN12.89314310
7MAP3K42.87106506
8PIK3CG2.58866313
9NTRK22.50125350
10WNK32.41770322
11PLK42.41050643
12GRK12.32011260
13ZAK2.24033249
14ACVR1B2.02057440
15OXSR11.77902618
16ADRBK21.74981073
17UHMK11.62240359
18CAMK2B1.62211667
19STK391.55372907
20MARK11.53626737
21KDR1.53093761
22TRPM71.49714393
23NEK21.47706601
24MAPKAPK31.40024719
25ADRBK11.39457044
26CHEK21.28158863
27FRK1.25513451
28CSNK1G21.21287300
29MKNK21.19492094
30CSNK1G31.17329658
31BMPR1B1.14034818
32BCKDK1.11257857
33CAMK2A1.06382297
34MET1.03115848
35CAMK41.00894112
36DYRK30.99648601
37PLK20.97745782
38NEK10.97328735
39RPS6KA50.97312719
40CDK150.93379135
41MAPK40.92954865
42CAMK2D0.91753380
43DYRK20.90529656
44CDK180.87700781
45GRK70.87077231
46CDK80.85878855
47CSNK1G10.82679117
48PRKCQ0.82593921
49STK38L0.82533589
50CDK11A0.81547100
51CAMK2G0.79609346
52CDK140.76889503
53PRKCG0.75548976
54WNK40.72866511
55PHKG20.69914065
56PHKG10.69914065
57STK110.68001484
58MATK0.65059620
59MAP2K10.64106214
60PRKCZ0.63411717
61DYRK1A0.60689508
62PRKCI0.58742185
63DYRK1B0.58608991
64MAP2K70.57761308
65MAP3K70.56033144
66MAP2K20.55126186
67DDR20.53790090
68EIF2AK20.53472720
69SYK0.52228875
70CDC42BPA0.50924113
71KIT0.50044458
72INSRR0.48996374
73OBSCN0.47641508
74PLK10.47279475
75FGR0.46775433
76CDK190.46685550
77DAPK20.46583453
78STK240.45673307
79PRKACA0.43298301
80ABL20.43114338
81PTK2B0.42542198
82IRAK40.42428610
83GRK50.42116678
84CSNK1A10.42072720
85MKNK10.41363091
86TTK0.41208991
87PRKCB0.40297282
88TGFBR10.39758450
89MAPK120.39024574
90CSF1R0.38814624
91CSNK1A1L0.38122579
92TLK10.35024223
93PRKG10.34737192
94PRKAA20.33344501
95MAPK30.33313179
96CSNK1D0.32681554
97CDK50.31700420
98PRKCD0.31254068
99PRKCA0.30727973
100PRKACB0.30084249

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005927.68791274
2Linoleic acid metabolism_Homo sapiens_hsa005916.89127561
3Ether lipid metabolism_Homo sapiens_hsa005654.71814651
4Nicotine addiction_Homo sapiens_hsa050333.48026534
5Arachidonic acid metabolism_Homo sapiens_hsa005903.08843264
6Fat digestion and absorption_Homo sapiens_hsa049752.62888236
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.36245336
8Glycerophospholipid metabolism_Homo sapiens_hsa005642.29423371
9Nitrogen metabolism_Homo sapiens_hsa009102.14990787
10Phototransduction_Homo sapiens_hsa047441.96775144
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95136820
12Ovarian steroidogenesis_Homo sapiens_hsa049131.86828596
13Basal transcription factors_Homo sapiens_hsa030221.81961418
14Propanoate metabolism_Homo sapiens_hsa006401.62788503
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59342442
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.48148186
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39137751
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23714491
19Vitamin B6 metabolism_Homo sapiens_hsa007501.21059395
20Sulfur metabolism_Homo sapiens_hsa009201.16365051
21Fatty acid elongation_Homo sapiens_hsa000621.12107370
22Parkinsons disease_Homo sapiens_hsa050121.08385148
23Fatty acid biosynthesis_Homo sapiens_hsa000611.07089368
24Butanoate metabolism_Homo sapiens_hsa006501.02276206
25Cocaine addiction_Homo sapiens_hsa050300.96318520
26Selenocompound metabolism_Homo sapiens_hsa004500.95422386
27Long-term depression_Homo sapiens_hsa047300.94703452
28Serotonergic synapse_Homo sapiens_hsa047260.93816405
29Sulfur relay system_Homo sapiens_hsa041220.88133007
30Tyrosine metabolism_Homo sapiens_hsa003500.86902466
31ABC transporters_Homo sapiens_hsa020100.84549494
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84161893
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79931014
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76286589
35Oxidative phosphorylation_Homo sapiens_hsa001900.72961909
36Chemical carcinogenesis_Homo sapiens_hsa052040.72772535
37Cholinergic synapse_Homo sapiens_hsa047250.65629623
38Pancreatic secretion_Homo sapiens_hsa049720.65628069
39Glutamatergic synapse_Homo sapiens_hsa047240.63741122
40Steroid biosynthesis_Homo sapiens_hsa001000.61408239
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.61186963
42Retinol metabolism_Homo sapiens_hsa008300.57383355
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.57305358
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57148793
45Amphetamine addiction_Homo sapiens_hsa050310.56120875
46One carbon pool by folate_Homo sapiens_hsa006700.56057943
47Calcium signaling pathway_Homo sapiens_hsa040200.55265244
48Cardiac muscle contraction_Homo sapiens_hsa042600.55044634
49Ras signaling pathway_Homo sapiens_hsa040140.53643141
50Glycerolipid metabolism_Homo sapiens_hsa005610.53348011
51Caffeine metabolism_Homo sapiens_hsa002320.49433628
52Sphingolipid metabolism_Homo sapiens_hsa006000.49246260
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48896274
54GnRH signaling pathway_Homo sapiens_hsa049120.47906362
55Tryptophan metabolism_Homo sapiens_hsa003800.47378493
56Alzheimers disease_Homo sapiens_hsa050100.46207756
57VEGF signaling pathway_Homo sapiens_hsa043700.45275837
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45239149
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44334663
60Homologous recombination_Homo sapiens_hsa034400.43400865
61Huntingtons disease_Homo sapiens_hsa050160.42506484
62Choline metabolism in cancer_Homo sapiens_hsa052310.42195017
63Peroxisome_Homo sapiens_hsa041460.41586834
64Gastric acid secretion_Homo sapiens_hsa049710.40990379
65Histidine metabolism_Homo sapiens_hsa003400.39633956
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39201780
67Mineral absorption_Homo sapiens_hsa049780.37800807
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35618122
69Metabolic pathways_Homo sapiens_hsa011000.35441260
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34594751
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33700387
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.32232359
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.30669606
74Lysine degradation_Homo sapiens_hsa003100.30058278
75Salivary secretion_Homo sapiens_hsa049700.28027928
76Morphine addiction_Homo sapiens_hsa050320.27292329
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27284185
78Fatty acid metabolism_Homo sapiens_hsa012120.26959946
79Platelet activation_Homo sapiens_hsa046110.24759698
80Fatty acid degradation_Homo sapiens_hsa000710.24622978
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24397331
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.23489165
83Dopaminergic synapse_Homo sapiens_hsa047280.23480078
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.20807923
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18289576
86Taste transduction_Homo sapiens_hsa047420.17864677
87Olfactory transduction_Homo sapiens_hsa047400.17707354
88RNA degradation_Homo sapiens_hsa030180.16564853
89Circadian rhythm_Homo sapiens_hsa047100.15963725
90African trypanosomiasis_Homo sapiens_hsa051430.15924160
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13531961
92Axon guidance_Homo sapiens_hsa043600.12958307
93Protein export_Homo sapiens_hsa030600.12677028
94Nucleotide excision repair_Homo sapiens_hsa034200.12667891
95RNA polymerase_Homo sapiens_hsa030200.12638954
96Arginine biosynthesis_Homo sapiens_hsa002200.12630819
97Phenylalanine metabolism_Homo sapiens_hsa003600.12174496
98Purine metabolism_Homo sapiens_hsa002300.11195887
99Oxytocin signaling pathway_Homo sapiens_hsa049210.11157483
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11015453

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