OR7A17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.73559504
2regulation of memory T cell differentiation (GO:0043380)4.76152045
3neuronal action potential propagation (GO:0019227)4.76109529
4detection of light stimulus involved in sensory perception (GO:0050962)4.66937974
5detection of light stimulus involved in visual perception (GO:0050908)4.66937974
6gamma-aminobutyric acid transport (GO:0015812)4.62851783
7L-fucose catabolic process (GO:0042355)4.42766821
8fucose catabolic process (GO:0019317)4.42766821
9L-fucose metabolic process (GO:0042354)4.42766821
10kynurenine metabolic process (GO:0070189)4.29916976
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.20050995
12indole-containing compound catabolic process (GO:0042436)4.05029747
13indolalkylamine catabolic process (GO:0046218)4.05029747
14tryptophan catabolic process (GO:0006569)4.05029747
15synaptic transmission, cholinergic (GO:0007271)3.86463164
16behavioral response to ethanol (GO:0048149)3.75265587
17rRNA catabolic process (GO:0016075)3.74516089
18indolalkylamine metabolic process (GO:0006586)3.62208626
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59319977
20cellular response to ATP (GO:0071318)3.46638740
21regulation of action potential (GO:0098900)3.45514626
22negative regulation of multicellular organism growth (GO:0040015)3.43700593
23maturation of 5.8S rRNA (GO:0000460)3.36989750
24protein prenylation (GO:0018342)3.35198265
25prenylation (GO:0097354)3.35198265
26tryptophan metabolic process (GO:0006568)3.31485565
27cellular ketone body metabolic process (GO:0046950)3.30952488
28sulfation (GO:0051923)3.30200525
29histone mRNA catabolic process (GO:0071044)3.26082023
30regulation of gene silencing by RNA (GO:0060966)3.22697686
31regulation of posttranscriptional gene silencing (GO:0060147)3.22697686
32regulation of gene silencing by miRNA (GO:0060964)3.22697686
33amine catabolic process (GO:0009310)3.22050280
34cellular biogenic amine catabolic process (GO:0042402)3.22050280
35platelet dense granule organization (GO:0060155)3.21840504
36negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21575028
37protein-cofactor linkage (GO:0018065)3.11572770
38neural tube formation (GO:0001841)3.11289450
39DNA deamination (GO:0045006)3.09633592
40ketone body metabolic process (GO:1902224)3.00359980
41negative regulation of mast cell activation (GO:0033004)2.98222711
42negative regulation of telomere maintenance (GO:0032205)2.95025572
43positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94318003
44detection of mechanical stimulus involved in sensory perception (GO:0050974)2.91520422
45glycerophospholipid catabolic process (GO:0046475)2.89505998
46protein neddylation (GO:0045116)2.89131608
47photoreceptor cell maintenance (GO:0045494)2.88940559
48phosphatidylinositol acyl-chain remodeling (GO:0036149)2.88678545
49response to pheromone (GO:0019236)2.88144583
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87869991
51parturition (GO:0007567)2.86425377
52regulation of MHC class I biosynthetic process (GO:0045343)2.86334245
53negative regulation of reactive oxygen species metabolic process (GO:2000378)2.85083319
54sex differentiation (GO:0007548)2.84392436
55seminiferous tubule development (GO:0072520)2.83155719
56regulation of neurotransmitter uptake (GO:0051580)2.79890694
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79056052
58regulation of nuclear cell cycle DNA replication (GO:0033262)2.77123515
59piRNA metabolic process (GO:0034587)2.76930210
60water-soluble vitamin biosynthetic process (GO:0042364)2.75143780
61pyrimidine nucleobase catabolic process (GO:0006208)2.75089678
62cAMP catabolic process (GO:0006198)2.75016158
63positive regulation of cAMP-mediated signaling (GO:0043950)2.73169373
64reflex (GO:0060004)2.72300244
65negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71275971
66neuronal action potential (GO:0019228)2.70859391
67nonmotile primary cilium assembly (GO:0035058)2.68828120
68kidney morphogenesis (GO:0060993)2.68512593
69indole-containing compound metabolic process (GO:0042430)2.67068280
70male meiosis I (GO:0007141)2.63899095
71pseudouridine synthesis (GO:0001522)2.63350691
72epithelial cilium movement (GO:0003351)2.62231563
73protein K11-linked deubiquitination (GO:0035871)2.62033338
74phosphatidylserine acyl-chain remodeling (GO:0036150)2.60625041
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59737069
76exogenous drug catabolic process (GO:0042738)2.59167431
77postsynaptic membrane organization (GO:0001941)2.57973583
78positive regulation of fatty acid oxidation (GO:0046321)2.57145393
79amino acid salvage (GO:0043102)2.56625146
80L-methionine salvage (GO:0071267)2.56625146
81L-methionine biosynthetic process (GO:0071265)2.56625146
82DNA methylation involved in gamete generation (GO:0043046)2.55813510
83regulation of hippo signaling (GO:0035330)2.55227753
84aromatic amino acid family catabolic process (GO:0009074)2.54503816
85regulation of cilium movement (GO:0003352)2.54357638
86coenzyme catabolic process (GO:0009109)2.53869115
87positive regulation of defense response to virus by host (GO:0002230)2.53756188
88ubiquinone biosynthetic process (GO:0006744)2.53574614
89cerebellar Purkinje cell differentiation (GO:0021702)2.52469431
90cytoplasmic mRNA processing body assembly (GO:0033962)2.50793460
91regulation of sequestering of triglyceride (GO:0010889)2.47915603
92energy coupled proton transport, down electrochemical gradient (GO:0015985)2.47226432
93ATP synthesis coupled proton transport (GO:0015986)2.47226432
94membrane depolarization during action potential (GO:0086010)2.46839501
95reciprocal DNA recombination (GO:0035825)2.46347603
96reciprocal meiotic recombination (GO:0007131)2.46347603
97axoneme assembly (GO:0035082)2.46285985
98protein K63-linked deubiquitination (GO:0070536)2.45657450
99methionine biosynthetic process (GO:0009086)2.45431963
100nucleobase catabolic process (GO:0046113)2.45387824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.27958953
2EZH2_22144423_ChIP-Seq_EOC_Human4.07110095
3VDR_22108803_ChIP-Seq_LS180_Human3.87243963
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94530314
5GBX2_23144817_ChIP-Seq_PC3_Human2.92746975
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56759867
7TAF15_26573619_Chip-Seq_HEK293_Human2.35763755
8IGF1R_20145208_ChIP-Seq_DFB_Human2.32182031
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18523432
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16333859
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08690489
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.06967161
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00830722
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00511912
15EWS_26573619_Chip-Seq_HEK293_Human1.95534886
16BCAT_22108803_ChIP-Seq_LS180_Human1.95530721
17ER_23166858_ChIP-Seq_MCF-7_Human1.91906644
18P300_19829295_ChIP-Seq_ESCs_Human1.80944179
19FUS_26573619_Chip-Seq_HEK293_Human1.77805249
20REST_21632747_ChIP-Seq_MESCs_Mouse1.73509086
21MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.71013794
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.70192326
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66580843
24MYC_18940864_ChIP-ChIP_HL60_Human1.62299240
25TP53_22573176_ChIP-Seq_HFKS_Human1.61844785
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60092257
27STAT3_23295773_ChIP-Seq_U87_Human1.59946930
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.59544168
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58308124
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54449780
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50792552
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49575600
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47010587
34AR_25329375_ChIP-Seq_VCAP_Human1.44452583
35IRF1_19129219_ChIP-ChIP_H3396_Human1.44145946
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42329265
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42103893
38* TCF4_23295773_ChIP-Seq_U87_Human1.41964461
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.41737463
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41737463
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41149571
42CBP_20019798_ChIP-Seq_JUKART_Human1.41149571
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39978277
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38736450
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37667441
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35074702
47SMAD4_21799915_ChIP-Seq_A2780_Human1.29845746
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.27803231
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27725191
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26494472
51AR_20517297_ChIP-Seq_VCAP_Human1.26481757
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26421452
53* RUNX2_22187159_ChIP-Seq_PCA_Human1.26175797
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.25370475
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.24186555
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23811630
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23811630
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22561636
59* NCOR_22424771_ChIP-Seq_293T_Human1.21653716
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21014091
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.19250592
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18254694
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18166250
64SOX2_19829295_ChIP-Seq_ESCs_Human1.18099985
65NANOG_19829295_ChIP-Seq_ESCs_Human1.18099985
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17953591
67TCF4_22108803_ChIP-Seq_LS180_Human1.15558242
68AR_21572438_ChIP-Seq_LNCaP_Human1.11771283
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11326787
70DROSHA_22980978_ChIP-Seq_HELA_Human1.11159971
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.10359205
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08043544
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07845391
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.07508905
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.07447173
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05761788
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04871657
78HOXB7_26014856_ChIP-Seq_BT474_Human1.03827511
79* ERA_21632823_ChIP-Seq_H3396_Human1.01941017
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01759731
81NANOG_20526341_ChIP-Seq_ESCs_Human1.01692150
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01684492
83OCT1_27270436_Chip-Seq_PROSTATE_Human1.01516759
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.01026224
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00632741
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00503970
87CDX2_22108803_ChIP-Seq_LS180_Human1.00450416
88RNF2_27304074_Chip-Seq_NSC_Mouse0.98061878
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97805173
90TAF2_19829295_ChIP-Seq_ESCs_Human0.97211152
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96999096
92OCT4_20526341_ChIP-Seq_ESCs_Human0.96510931
93P53_22387025_ChIP-Seq_ESCs_Mouse0.95605821
94TAL1_26923725_Chip-Seq_HPCs_Mouse0.95573473
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95026768
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.94968557
97P53_21459846_ChIP-Seq_SAOS-2_Human0.94304757
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.94284859
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.94218764
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94099040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception3.36164479
2MP0002736_abnormal_nociception_after3.29946545
3MP0003646_muscle_fatigue2.98428929
4MP0001986_abnormal_taste_sensitivity2.85033613
5MP0005645_abnormal_hypothalamus_physiol2.83673626
6MP0000569_abnormal_digit_pigmentation2.76625851
7MP0002102_abnormal_ear_morphology2.58545695
8MP0003136_yellow_coat_color2.43114884
9MP0005551_abnormal_eye_electrophysiolog2.35334296
10MP0009745_abnormal_behavioral_response2.35313884
11MP0002876_abnormal_thyroid_physiology2.35032520
12MP0008875_abnormal_xenobiotic_pharmacok2.34096547
13MP0008877_abnormal_DNA_methylation2.26986842
14MP0006276_abnormal_autonomic_nervous2.25797701
15MP0003252_abnormal_bile_duct2.23349746
16MP0004147_increased_porphyrin_level2.13955938
17MP0004043_abnormal_pH_regulation2.08172759
18MP0003195_calcinosis2.06305958
19MP0003011_delayed_dark_adaptation1.98491093
20MP0005646_abnormal_pituitary_gland1.96804022
21MP0009046_muscle_twitch1.88810351
22MP0008872_abnormal_physiological_respon1.86878816
23MP0004885_abnormal_endolymph1.84579782
24MP0004142_abnormal_muscle_tone1.84568296
25MP0002272_abnormal_nervous_system1.83544517
26MP0003787_abnormal_imprinting1.77558509
27MP0000427_abnormal_hair_cycle1.76469921
28MP0002653_abnormal_ependyma_morphology1.72404782
29MP0004133_heterotaxia1.70875607
30MP0001501_abnormal_sleep_pattern1.70051044
31MP0002638_abnormal_pupillary_reflex1.68290496
32MP0005253_abnormal_eye_physiology1.68281531
33MP0005083_abnormal_biliary_tract1.66284002
34MP0005084_abnormal_gallbladder_morpholo1.51112632
35MP0002733_abnormal_thermal_nociception1.49526865
36MP0006292_abnormal_olfactory_placode1.49034184
37MP0002064_seizures1.47835903
38MP0002572_abnormal_emotion/affect_behav1.45087357
39MP0002160_abnormal_reproductive_system1.41467346
40MP0006072_abnormal_retinal_apoptosis1.41438956
41MP0003718_maternal_effect1.41255798
42MP0005389_reproductive_system_phenotype1.39738415
43MP0002837_dystrophic_cardiac_calcinosis1.38280871
44MP0001970_abnormal_pain_threshold1.36243801
45MP0003880_abnormal_central_pattern1.30984056
46MP0002928_abnormal_bile_duct1.29271959
47MP0002067_abnormal_sensory_capabilities1.25362730
48MP0005174_abnormal_tail_pigmentation1.25218664
49MP0004130_abnormal_muscle_cell1.24904363
50MP0000631_abnormal_neuroendocrine_gland1.24194031
51MP0001486_abnormal_startle_reflex1.23509581
52MP0003635_abnormal_synaptic_transmissio1.21589192
53MP0002557_abnormal_social/conspecific_i1.20986095
54MP0000230_abnormal_systemic_arterial1.19364783
55MP0002234_abnormal_pharynx_morphology1.19277734
56MP0005085_abnormal_gallbladder_physiolo1.19241663
57MP0004924_abnormal_behavior1.18757172
58MP0005386_behavior/neurological_phenoty1.18757172
59MP0010386_abnormal_urinary_bladder1.18410051
60MP0001529_abnormal_vocalization1.17287517
61MP0002095_abnormal_skin_pigmentation1.16735218
62MP0002138_abnormal_hepatobiliary_system1.13719523
63MP0005410_abnormal_fertilization1.13448168
64MP0002735_abnormal_chemical_nociception1.10627210
65MP0002063_abnormal_learning/memory/cond1.09766006
66MP0005647_abnormal_sex_gland1.09725709
67MP0002938_white_spotting1.08563429
68MP0001919_abnormal_reproductive_system1.07203562
69MP0002752_abnormal_somatic_nervous0.93569299
70MP0004145_abnormal_muscle_electrophysio0.93442712
71MP0009764_decreased_sensitivity_to0.93242880
72MP0005167_abnormal_blood-brain_barrier0.91228625
73MP0005195_abnormal_posterior_eye0.91151474
74MP0002693_abnormal_pancreas_physiology0.91141953
75MP0001485_abnormal_pinna_reflex0.90400474
76MP0000026_abnormal_inner_ear0.88483176
77MP0005171_absent_coat_pigmentation0.88198715
78MP0000470_abnormal_stomach_morphology0.87745899
79MP0002163_abnormal_gland_morphology0.84651473
80MP0004742_abnormal_vestibular_system0.84144307
81MP0002184_abnormal_innervation0.83182638
82MP0001664_abnormal_digestion0.82080656
83MP0002229_neurodegeneration0.81051086
84MP0001764_abnormal_homeostasis0.80747683
85MP0003121_genomic_imprinting0.80581526
86MP0003698_abnormal_male_reproductive0.80315119
87MP0008775_abnormal_heart_ventricle0.79648432
88MP0001905_abnormal_dopamine_level0.79086562
89MP0001324_abnormal_eye_pigmentation0.77066314
90MP0003638_abnormal_response/metabolism_0.76553802
91MP0008789_abnormal_olfactory_epithelium0.76150922
92MP0002734_abnormal_mechanical_nocicepti0.75168419
93MP0003890_abnormal_embryonic-extraembry0.73442052
94MP0001502_abnormal_circadian_rhythm0.69676077
95MP0000372_irregular_coat_pigmentation0.69644462
96MP0000383_abnormal_hair_follicle0.68317159
97MP0000955_abnormal_spinal_cord0.67579460
98MP0002277_abnormal_respiratory_mucosa0.65555587
99MP0005365_abnormal_bile_salt0.65128771
100MP0001984_abnormal_olfaction0.65126785

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.12564356
2Congenital stationary night blindness (HP:0007642)4.00008468
3Hyperalaninemia (HP:0003348)3.92512166
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.92512166
5Abnormality of alanine metabolism (HP:0010916)3.92512166
6Gaze-evoked nystagmus (HP:0000640)3.87756967
7Pendular nystagmus (HP:0012043)3.80480267
8Pancreatic fibrosis (HP:0100732)3.79146059
9Genetic anticipation (HP:0003743)3.72556925
10Abnormality of midbrain morphology (HP:0002418)3.69893384
11Molar tooth sign on MRI (HP:0002419)3.69893384
12Progressive cerebellar ataxia (HP:0002073)3.43050134
13Polydipsia (HP:0001959)3.41395818
14Abnormal drinking behavior (HP:0030082)3.41395818
15True hermaphroditism (HP:0010459)3.36961579
16Abnormality of the renal cortex (HP:0011035)3.33746431
17Abolished electroretinogram (ERG) (HP:0000550)3.28647334
18Febrile seizures (HP:0002373)3.09307520
19Attenuation of retinal blood vessels (HP:0007843)3.02558273
20Hyperventilation (HP:0002883)2.96017584
21Increased corneal curvature (HP:0100692)2.95087520
22Keratoconus (HP:0000563)2.95087520
23Decreased circulating renin level (HP:0003351)2.94885900
24Abnormality of the renal medulla (HP:0100957)2.94301892
25Nephronophthisis (HP:0000090)2.90039719
26Tubular atrophy (HP:0000092)2.85124156
27Inability to walk (HP:0002540)2.80459561
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71300117
29Abnormal rod and cone electroretinograms (HP:0008323)2.70190578
30Polyuria (HP:0000103)2.69830288
31Hypoplasia of the pons (HP:0012110)2.69519886
32Abnormality of the pons (HP:0007361)2.66544966
33Chorioretinal atrophy (HP:0000533)2.63361876
34Absent/shortened dynein arms (HP:0200106)2.61107904
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.61107904
36Chronic hepatic failure (HP:0100626)2.60494319
37Cystic liver disease (HP:0006706)2.60070179
38Type II lissencephaly (HP:0007260)2.49423203
39Decreased central vision (HP:0007663)2.49248248
40Protruding tongue (HP:0010808)2.42780321
41Clumsiness (HP:0002312)2.38665690
42Progressive inability to walk (HP:0002505)2.37766171
43Hypoproteinemia (HP:0003075)2.31692587
44Broad-based gait (HP:0002136)2.31299067
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.27136249
46Abnormal biliary tract physiology (HP:0012439)2.27049636
47Bile duct proliferation (HP:0001408)2.27049636
48Medial flaring of the eyebrow (HP:0010747)2.23434630
49Tubulointerstitial fibrosis (HP:0005576)2.21908781
50Focal seizures (HP:0007359)2.20368481
51Sclerocornea (HP:0000647)2.16987866
52Hemiparesis (HP:0001269)2.16092183
53Rib fusion (HP:0000902)2.15697370
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.15558168
55Abnormal urine output (HP:0012590)2.12758323
56Absent speech (HP:0001344)2.11484892
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09022908
58Action tremor (HP:0002345)2.08858581
59Absence seizures (HP:0002121)2.07950785
60Hyperglycinuria (HP:0003108)2.07647344
61Concave nail (HP:0001598)2.05422322
62Lissencephaly (HP:0001339)2.04614249
63Congenital hepatic fibrosis (HP:0002612)2.04392779
64Ketoacidosis (HP:0001993)1.98606241
65Dialeptic seizures (HP:0011146)1.96595081
66Atonic seizures (HP:0010819)1.96029883
67Optic nerve hypoplasia (HP:0000609)1.95281597
68Tubulointerstitial abnormality (HP:0001969)1.90535271
69Urinary bladder sphincter dysfunction (HP:0002839)1.90441188
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90232571
71Fair hair (HP:0002286)1.90090582
72Focal motor seizures (HP:0011153)1.88891718
73Abnormality of macular pigmentation (HP:0008002)1.88092991
74Tachypnea (HP:0002789)1.87776045
75Large for gestational age (HP:0001520)1.87347360
76Renal cortical cysts (HP:0000803)1.86856603
77Bony spicule pigmentary retinopathy (HP:0007737)1.86616687
78Abnormality of renal excretion (HP:0011036)1.84332199
79Bulbous nose (HP:0000414)1.79797968
80Impaired smooth pursuit (HP:0007772)1.78513381
81Stomatitis (HP:0010280)1.78192459
82Prostate neoplasm (HP:0100787)1.77178956
83Abnormality of DNA repair (HP:0003254)1.77064121
84Anencephaly (HP:0002323)1.74434998
85Constricted visual fields (HP:0001133)1.73225472
86Hyperglycinemia (HP:0002154)1.71604203
87Furrowed tongue (HP:0000221)1.71480801
88Metabolic alkalosis (HP:0200114)1.70585235
89Abnormality of serum amino acid levels (HP:0003112)1.70276673
90Asplenia (HP:0001746)1.69577210
91Male pseudohermaphroditism (HP:0000037)1.68337564
92Ketosis (HP:0001946)1.68317428
93Arthropathy (HP:0003040)1.67817562
94Abnormality of ocular smooth pursuit (HP:0000617)1.66790629
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.66620281
96Pachygyria (HP:0001302)1.66595319
97Hypoplastic iliac wings (HP:0002866)1.66360390
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65224577
99Abnormality of renin-angiotensin system (HP:0000847)1.65177605
100Retinitis pigmentosa (HP:0000510)1.64094064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.69056518
2ADRBK24.49624088
3MAP4K23.30505032
4WNK42.81735997
5DAPK22.65992938
6TLK12.60350156
7GRK12.48679299
8CASK2.46838640
9STK38L2.43652123
10OXSR12.33540252
11PINK12.15968525
12CDK192.11609639
13ZAK2.03127551
14BMPR1B1.89055254
15MAP2K71.83186305
16NUAK11.80425058
17MAP3K41.72316013
18TXK1.67730111
19MAPK131.55776577
20WNK31.54923074
21ADRBK11.46548009
22MKNK21.45668966
23ACVR1B1.41439933
24CAMKK21.40758649
25TAOK31.37351482
26STK161.32306384
27NTRK21.16891210
28DYRK21.15748437
29BCR1.11658144
30MARK11.10059915
31MAPKAPK51.07422931
32PTK2B1.00947889
33TEC1.00072666
34PRKCE0.99016068
35MKNK10.95876618
36IRAK10.95129393
37PAK30.95122871
38STK30.93787364
39PRKCG0.93546767
40INSRR0.90115317
41PRKCQ0.86707427
42MAPKAPK30.85191104
43BRSK20.85122646
44TIE10.82636298
45TNK20.78499642
46NTRK30.77630259
47STK390.76081518
48NEK90.75750029
49EPHA40.70538782
50PNCK0.67258654
51LIMK10.64254416
52PHKG20.62867392
53PHKG10.62867392
54PIK3CA0.62780177
55RPS6KA50.62038934
56MAP3K70.60997971
57ITK0.60385410
58CAMK2A0.59975932
59PLK20.58835933
60STK110.58608780
61MAPK150.56907537
62VRK10.55366243
63TAF10.53481709
64FGFR20.51521388
65CSNK1G20.51235993
66SYK0.50965448
67DYRK1A0.50436566
68PRKCI0.50184710
69ATR0.49982458
70STK380.49026800
71CAMK10.48918640
72MAP3K90.48618724
73TNIK0.47383418
74PKN10.47361568
75CSNK1A1L0.46904409
76SIK20.46723992
77NEK20.45010121
78PRKACA0.44894197
79IKBKB0.44642594
80RPS6KA60.44430790
81CSNK1G30.44218308
82CSNK1A10.43295433
83TGFBR10.42855660
84CAMK40.42268065
85CHEK20.41542141
86PRKCZ0.37425003
87PRKCA0.37044655
88STK240.35136736
89CSNK1G10.35121592
90GRK50.34900788
91PLK10.34092777
92PRKG10.34071073
93CSNK1D0.32935678
94PRKAA20.32901951
95BTK0.31719064
96BLK0.31113548
97PRKAA10.29763117
98BCKDK0.27936635
99MAP2K60.26435751
100MAP2K40.25222614

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.13663378
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.08329876
3Nitrogen metabolism_Homo sapiens_hsa009102.98233847
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.74528961
5Phototransduction_Homo sapiens_hsa047442.52852399
6Nicotine addiction_Homo sapiens_hsa050332.48875254
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25015283
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23754045
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12796250
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11450986
11Butanoate metabolism_Homo sapiens_hsa006502.09804432
12Ether lipid metabolism_Homo sapiens_hsa005652.08395647
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.00387084
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99954284
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91786337
16Caffeine metabolism_Homo sapiens_hsa002321.82803848
17Morphine addiction_Homo sapiens_hsa050321.68212337
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67598421
19Tryptophan metabolism_Homo sapiens_hsa003801.67286085
20Taste transduction_Homo sapiens_hsa047421.61021390
21Arachidonic acid metabolism_Homo sapiens_hsa005901.58981367
22Basal transcription factors_Homo sapiens_hsa030221.56345331
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.56342581
24RNA polymerase_Homo sapiens_hsa030201.37155572
25* Olfactory transduction_Homo sapiens_hsa047401.34703997
26ABC transporters_Homo sapiens_hsa020101.33509456
27Selenocompound metabolism_Homo sapiens_hsa004501.30655470
28Glycerolipid metabolism_Homo sapiens_hsa005611.30605175
29Homologous recombination_Homo sapiens_hsa034401.27769557
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.25406759
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.24938992
32beta-Alanine metabolism_Homo sapiens_hsa004101.24209922
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.23380702
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20838270
35Histidine metabolism_Homo sapiens_hsa003401.19327245
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17175704
37Fanconi anemia pathway_Homo sapiens_hsa034601.16164118
38Propanoate metabolism_Homo sapiens_hsa006401.15318747
39Salivary secretion_Homo sapiens_hsa049701.14680059
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14448617
41GABAergic synapse_Homo sapiens_hsa047271.14014967
42Oxidative phosphorylation_Homo sapiens_hsa001901.12922336
43Retinol metabolism_Homo sapiens_hsa008301.10949648
44Serotonergic synapse_Homo sapiens_hsa047261.10861878
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10231051
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06076380
47Chemical carcinogenesis_Homo sapiens_hsa052041.05250112
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03219760
49Peroxisome_Homo sapiens_hsa041461.01730813
50Circadian entrainment_Homo sapiens_hsa047131.00168955
51Glutamatergic synapse_Homo sapiens_hsa047240.98018512
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96681198
53Fat digestion and absorption_Homo sapiens_hsa049750.95917763
54Insulin secretion_Homo sapiens_hsa049110.93541386
55Ovarian steroidogenesis_Homo sapiens_hsa049130.92809849
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89424201
57Cardiac muscle contraction_Homo sapiens_hsa042600.87029670
58Asthma_Homo sapiens_hsa053100.85653820
59Calcium signaling pathway_Homo sapiens_hsa040200.80065755
60Parkinsons disease_Homo sapiens_hsa050120.78118087
61Dorso-ventral axis formation_Homo sapiens_hsa043200.77627071
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74009808
63Long-term depression_Homo sapiens_hsa047300.73714700
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71852356
65Protein export_Homo sapiens_hsa030600.68006564
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.65654033
67Fatty acid biosynthesis_Homo sapiens_hsa000610.64660248
68Graft-versus-host disease_Homo sapiens_hsa053320.62167006
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61761672
70Oxytocin signaling pathway_Homo sapiens_hsa049210.58345732
71Primary immunodeficiency_Homo sapiens_hsa053400.57539295
72Mineral absorption_Homo sapiens_hsa049780.56462080
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55824513
74Regulation of autophagy_Homo sapiens_hsa041400.54415614
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53604905
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.52622567
77Type I diabetes mellitus_Homo sapiens_hsa049400.52460718
78Autoimmune thyroid disease_Homo sapiens_hsa053200.51527269
79Allograft rejection_Homo sapiens_hsa053300.50899354
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50143084
81Gastric acid secretion_Homo sapiens_hsa049710.49884209
82Alzheimers disease_Homo sapiens_hsa050100.49609527
83Cocaine addiction_Homo sapiens_hsa050300.49388396
84Metabolic pathways_Homo sapiens_hsa011000.48708955
85RNA degradation_Homo sapiens_hsa030180.48517035
86Fatty acid degradation_Homo sapiens_hsa000710.48119042
87Purine metabolism_Homo sapiens_hsa002300.46537622
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.45824386
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44002124
90Dopaminergic synapse_Homo sapiens_hsa047280.43499339
91Huntingtons disease_Homo sapiens_hsa050160.40530079
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40395115
93cAMP signaling pathway_Homo sapiens_hsa040240.39762926
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38107809
95One carbon pool by folate_Homo sapiens_hsa006700.37743654
96Cholinergic synapse_Homo sapiens_hsa047250.34944452
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33791640
98Platelet activation_Homo sapiens_hsa046110.32669694
99Arginine and proline metabolism_Homo sapiens_hsa003300.30838107
100Pancreatic secretion_Homo sapiens_hsa049720.29819039

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