ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	6.36629741
2	regulation of glucokinase activity (GO:0033131)	6.13795412
3	regulation of hexokinase activity (GO:1903299)	6.13795412
4	platelet dense granule organization (GO:0060155)	5.09902975
5	endothelial cell morphogenesis (GO:0001886)	4.97799186
6	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	4.81685631
7	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.75009561
8	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.62483024
9	retinal metabolic process (GO:0042574)	4.36959961
10	respiratory chain complex IV assembly (GO:0008535)	4.26074209
11	limb bud formation (GO:0060174)	3.99677146
12	piRNA metabolic process (GO:0034587)	3.93939574
13	dopamine transport (GO:0015872)	3.90010755
14	L-methionine salvage (GO:0071267)	3.84271142
15	L-methionine biosynthetic process (GO:0071265)	3.84271142
16	amino acid salvage (GO:0043102)	3.84271142
17	cytochrome complex assembly (GO:0017004)	3.78062409
18	indole-containing compound catabolic process (GO:0042436)	3.73441886
19	indolalkylamine catabolic process (GO:0046218)	3.73441886
20	tryptophan catabolic process (GO:0006569)	3.73441886
21	carnitine transmembrane transport (GO:1902603)	3.70975588
22	branching involved in prostate gland morphogenesis (GO:0060442)	3.68852646
23	cellular ketone body metabolic process (GO:0046950)	3.61258619
24	lung vasculature development (GO:0060426)	3.51245014
25	carnitine transport (GO:0015879)	3.49600288
26	amino-acid betaine transport (GO:0015838)	3.49600288
27	ketone body metabolic process (GO:1902224)	3.49582843
28	carnitine shuttle (GO:0006853)	3.48561411
29	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.44804273
30	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.44804273
31	glial cell proliferation (GO:0014009)	3.44250508
32	lung morphogenesis (GO:0060425)	3.43261103
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.41290086
34	regulation of translation, ncRNA-mediated (GO:0045974)	3.41290086
35	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.41290086
36	fatty acid transmembrane transport (GO:1902001)	3.40565315
37	startle response (GO:0001964)	3.38257623
38	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.36052321
39	neural tube formation (GO:0001841)	3.34476838
40	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.30608177
41	kidney morphogenesis (GO:0060993)	3.29598570
42	cornea development in camera-type eye (GO:0061303)	3.25639199
43	behavioral response to ethanol (GO:0048149)	3.24019699
44	tryptophan metabolic process (GO:0006568)	3.14046704
45	regulation of MHC class I biosynthetic process (GO:0045343)	3.13129950
46	sympathetic nervous system development (GO:0048485)	3.04909470
47	mitotic cell cycle arrest (GO:0071850)	3.01461211
48	histone H3-K36 demethylation (GO:0070544)	3.00537312
49	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.00364672
50	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.99652312
51	indolalkylamine metabolic process (GO:0006586)	2.96957718
52	photoreceptor cell development (GO:0042461)	2.94513896
53	quaternary ammonium group transport (GO:0015697)	2.92978603
54	amine catabolic process (GO:0009310)	2.89810361
55	cellular biogenic amine catabolic process (GO:0042402)	2.89810361
56	methionine biosynthetic process (GO:0009086)	2.87665339
57	transepithelial transport (GO:0070633)	2.84417036
58	phasic smooth muscle contraction (GO:0014821)	2.83235520
59	heme transport (GO:0015886)	2.80580086
60	regulation of neurotransmitter uptake (GO:0051580)	2.76719005
61	regulation of protein polyubiquitination (GO:1902914)	2.76350282
62	DNA methylation involved in gamete generation (GO:0043046)	2.71332601
63	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.71144446
64	organic cation transport (GO:0015695)	2.71004799
65	proline transport (GO:0015824)	2.69826074
66	natural killer cell activation involved in immune response (GO:0002323)	2.69712297
67	branched-chain amino acid catabolic process (GO:0009083)	2.68045531
68	cartilage morphogenesis (GO:0060536)	2.67982815
69	embryonic epithelial tube formation (GO:0001838)	2.67029114
70	anterograde synaptic vesicle transport (GO:0048490)	2.66912653
71	prenylation (GO:0097354)	2.66867847
72	protein prenylation (GO:0018342)	2.66867847
73	eye photoreceptor cell development (GO:0042462)	2.62769174
74	lactate metabolic process (GO:0006089)	2.61544572
75	cilium or flagellum-dependent cell motility (GO:0001539)	2.61434145
76	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.61041800
77	regulation of mitotic spindle checkpoint (GO:1903504)	2.61041800
78	positive regulation of glycolytic process (GO:0045821)	2.59437056
79	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.58666540
80	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.58666540
81	regulation of keratinocyte proliferation (GO:0010837)	2.58562649
82	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.57216216
83	GPI anchor metabolic process (GO:0006505)	2.56986759
84	peristalsis (GO:0030432)	2.55316371
85	detection of light stimulus involved in visual perception (GO:0050908)	2.54695303
86	detection of light stimulus involved in sensory perception (GO:0050962)	2.54695303
87	NAD biosynthetic process (GO:0009435)	2.54218090
88	resolution of meiotic recombination intermediates (GO:0000712)	2.53812282
89	cellular response to vitamin D (GO:0071305)	2.53701399
90	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.53346498
91	adaptation of signaling pathway (GO:0023058)	2.51653688
92	positive regulation of cAMP-mediated signaling (GO:0043950)	2.51212870
93	auditory receptor cell differentiation (GO:0042491)	2.50625220
94	regulation of female gonad development (GO:2000194)	2.47174821
95	retinoic acid metabolic process (GO:0042573)	2.47072438
96	epithelial tube formation (GO:0072175)	2.45586154
97	cilium morphogenesis (GO:0060271)	2.45507408
98	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.43003377
99	embryonic forelimb morphogenesis (GO:0035115)	2.42925335
100	positive regulation of protein autophosphorylation (GO:0031954)	2.42513161

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	6.23447357
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.19721044
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.99147583
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.85380482
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.78531165
6	FUS_26573619_Chip-Seq_HEK293_Human	2.78303912
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.39462832
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39232755
9	P300_19829295_ChIP-Seq_ESCs_Human	2.34494017
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31811717
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.04298319
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.02881534
13	VDR_22108803_ChIP-Seq_LS180_Human	1.98712170
14	BCAT_22108803_ChIP-Seq_LS180_Human	1.97828513
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.95749687
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.94002996
17	EWS_26573619_Chip-Seq_HEK293_Human	1.92901669
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86064695
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.82219567
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78074692
21	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.77786668
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76940880
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.73904834
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71728367
25	STAT3_23295773_ChIP-Seq_U87_Human	1.63704380
26	AR_25329375_ChIP-Seq_VCAP_Human	1.62364476
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.61223409
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56111257
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56111257
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.54636354
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.52952088
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51470572
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48363046
34	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.47942066
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46742561
36	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.44984899
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44444460
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42688640
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38552159
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38515705
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38515705
42	TCF4_23295773_ChIP-Seq_U87_Human	1.38410315
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37140901
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36937838
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36758567
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.33557727
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33557727
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.33251487
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32537200
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30865398
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.28871454
52	CDX2_22108803_ChIP-Seq_LS180_Human	1.28807151
53	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.28115582
54	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.28115582
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28018206
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27841984
57	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.27682675
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26769895
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26154166
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24993706
61	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.22119677
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21695665
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21503732
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.20327011
65	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.18470037
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16874305
67	CJUN_26792858_Chip-Seq_BT549_Human	1.16615728
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15445940
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15382098
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14973587
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14167151
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14155157
73	AHR_22903824_ChIP-Seq_MCF-7_Human	1.13323835
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12920854
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11820895
76	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11465682
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10820757
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.09719018
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09159088
80	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.09137472
81	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.08840714
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08776601
83	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.08755761
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08603948
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08301426
86	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.06815688
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05652520
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05652520
89	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.05589881
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04064330
91	MYC_18940864_ChIP-ChIP_HL60_Human	1.02769711
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02405002
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01883336
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01746171
95	P300_18555785_Chip-Seq_ESCs_Mouse	1.01233042
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01213399
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99671497
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98383662
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.96509838
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96331706

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.46315617
2	MP0000569_abnormal_digit_pigmentation	3.26451894
3	MP0000372_irregular_coat_pigmentation	3.16884219
4	MP0005075_abnormal_melanosome_morpholog	3.11914042
5	MP0008877_abnormal_DNA_methylation	3.02723450
6	MP0005645_abnormal_hypothalamus_physiol	2.95445985
7	MP0000015_abnormal_ear_pigmentation	2.92964231
8	MP0000537_abnormal_urethra_morphology	2.70852724
9	MP0002928_abnormal_bile_duct	2.51178219
10	MP0003195_calcinosis	2.42285584
11	MP0002163_abnormal_gland_morphology	2.35327248
12	MP0005379_endocrine/exocrine_gland_phen	2.33395353
13	MP0003828_pulmonary_edema	2.03726398
14	MP0002282_abnormal_trachea_morphology	1.94924103
15	MP0003806_abnormal_nucleotide_metabolis	1.94470791
16	MP0003942_abnormal_urinary_system	1.93205490
17	MP0002102_abnormal_ear_morphology	1.88349876
18	MP0003315_abnormal_perineum_morphology	1.88115233
19	MP0005187_abnormal_penis_morphology	1.87910193
20	MP0000516_abnormal_urinary_system	1.82997474
21	MP0005367_renal/urinary_system_phenotyp	1.82997474
22	MP0008875_abnormal_xenobiotic_pharmacok	1.81540337
23	MP0005389_reproductive_system_phenotype	1.77895190
24	MP0003950_abnormal_plasma_membrane	1.77164358
25	MP0005174_abnormal_tail_pigmentation	1.74294851
26	MP0002160_abnormal_reproductive_system	1.73387445
27	MP0003136_yellow_coat_color	1.71389265
28	MP0003880_abnormal_central_pattern	1.71087155
29	MP0005551_abnormal_eye_electrophysiolog	1.61236035
30	MP0000538_abnormal_urinary_bladder	1.59749063
31	MP0001764_abnormal_homeostasis	1.57406867
32	MP0004381_abnormal_hair_follicle	1.57082553
33	MP0004145_abnormal_muscle_electrophysio	1.55101632
34	MP0002138_abnormal_hepatobiliary_system	1.53572502
35	MP0002254_reproductive_system_inflammat	1.51589741
36	MP0006276_abnormal_autonomic_nervous	1.49021944
37	MP0005084_abnormal_gallbladder_morpholo	1.47501186
38	MP0002837_dystrophic_cardiac_calcinosis	1.46089368
39	MP0002751_abnormal_autonomic_nervous	1.46006262
40	MP0002938_white_spotting	1.43298537
41	MP0004084_abnormal_cardiac_muscle	1.38287763
42	MP0005646_abnormal_pituitary_gland	1.38158362
43	MP0002876_abnormal_thyroid_physiology	1.35337914
44	MP0002090_abnormal_vision	1.35198887
45	MP0008872_abnormal_physiological_respon	1.35141137
46	MP0002095_abnormal_skin_pigmentation	1.34721456
47	MP0004043_abnormal_pH_regulation	1.34542117
48	MP0005410_abnormal_fertilization	1.33955989
49	MP0001486_abnormal_startle_reflex	1.33048004
50	MP0001919_abnormal_reproductive_system	1.32131129
51	MP0002132_abnormal_respiratory_system	1.30427599
52	MP0006054_spinal_hemorrhage	1.25903358
53	MP0005167_abnormal_blood-brain_barrier	1.23910774
54	MP0003045_fibrosis	1.23238749
55	MP0002295_abnormal_pulmonary_circulatio	1.20900879
56	MP0000383_abnormal_hair_follicle	1.19094193
57	MP0001984_abnormal_olfaction	1.19072956
58	MP0009745_abnormal_behavioral_response	1.18107553
59	MP0001968_abnormal_touch/_nociception	1.15859482
60	MP0003252_abnormal_bile_duct	1.10974789
61	MP0002139_abnormal_hepatobiliary_system	1.08939773
62	MP0005253_abnormal_eye_physiology	1.08771017
63	MP0010030_abnormal_orbit_morphology	1.06371469
64	MP0002736_abnormal_nociception_after	1.03853357
65	MP0004147_increased_porphyrin_level	1.01847855
66	MP0001324_abnormal_eye_pigmentation	1.01743830
67	MP0003943_abnormal_hepatobiliary_system	0.96389135
68	MP0003937_abnormal_limbs/digits/tail_de	0.94690149
69	MP0009780_abnormal_chondrocyte_physiolo	0.93086606
70	MP0004133_heterotaxia	0.91291280
71	MP0001501_abnormal_sleep_pattern	0.91111893
72	MP0000371_diluted_coat_color	0.90534720
73	MP0001529_abnormal_vocalization	0.89047848
74	MP0005220_abnormal_exocrine_pancreas	0.86671227
75	MP0002277_abnormal_respiratory_mucosa	0.86568401
76	MP0004036_abnormal_muscle_relaxation	0.85165499
77	MP0003172_abnormal_lysosome_physiology	0.85119410
78	MP0000534_abnormal_ureter_morphology	0.84585034
79	MP0002693_abnormal_pancreas_physiology	0.83798282
80	MP0001986_abnormal_taste_sensitivity	0.82860082
81	MP0006072_abnormal_retinal_apoptosis	0.81996282
82	MP0005360_urolithiasis	0.81841223
83	MP0003011_delayed_dark_adaptation	0.81373108
84	MP0000613_abnormal_salivary_gland	0.80282720
85	MP0000653_abnormal_sex_gland	0.78244693
86	MP0005408_hypopigmentation	0.78151333
87	MP0002557_abnormal_social/conspecific_i	0.75063038
88	MP0002272_abnormal_nervous_system	0.74252630
89	MP0002168_other_aberrant_phenotype	0.74197097
90	MP0004142_abnormal_muscle_tone	0.73514586
91	MP0009046_muscle_twitch	0.71893415
92	MP0010678_abnormal_skin_adnexa	0.71626655
93	MP0000631_abnormal_neuroendocrine_gland	0.71600454
94	MP0010386_abnormal_urinary_bladder	0.71506751
95	MP0003755_abnormal_palate_morphology	0.71465491
96	MP0002184_abnormal_innervation	0.70982245
97	MP0001944_abnormal_pancreas_morphology	0.70291345
98	MP0003122_maternal_imprinting	0.68429254
99	MP0002177_abnormal_outer_ear	0.67370281
100	MP0005647_abnormal_sex_gland	0.65933537

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short 1st metacarpal (HP:0010034)	5.06303248
2	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	5.06303248
3	Abnormality of the 1st metacarpal (HP:0010009)	4.43606593
4	Type II lissencephaly (HP:0007260)	4.14202039
5	Methylmalonic acidemia (HP:0002912)	3.93194829
6	Pancreatic cysts (HP:0001737)	3.81364523
7	Bile duct proliferation (HP:0001408)	3.66171393
8	Abnormal biliary tract physiology (HP:0012439)	3.66171393
9	Pancreatic fibrosis (HP:0100732)	3.57132912
10	True hermaphroditism (HP:0010459)	3.51888869
11	Congenital stationary night blindness (HP:0007642)	3.39955431
12	3-Methylglutaconic aciduria (HP:0003535)	3.27583872
13	Delayed CNS myelination (HP:0002188)	3.25873446
14	Short phalanx of the thumb (HP:0009660)	3.12046165
15	Short 5th finger (HP:0009237)	3.08785375
16	Spontaneous abortion (HP:0005268)	3.08080019
17	Septate vagina (HP:0001153)	3.07982372
18	Cerebellar dysplasia (HP:0007033)	3.01177329
19	Albinism (HP:0001022)	2.97880479
20	Abnormal tarsal ossification (HP:0008369)	2.96284844
21	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.84792240
22	Chronic hepatic failure (HP:0100626)	2.84372603
23	Abnormal drinking behavior (HP:0030082)	2.74246160
24	Polydipsia (HP:0001959)	2.74246160
25	Abnormality of the renal cortex (HP:0011035)	2.70879774
26	Methylmalonic aciduria (HP:0012120)	2.65308361
27	Abnormality of the pons (HP:0007361)	2.62576073
28	Short hallux (HP:0010109)	2.61586395
29	Ketoacidosis (HP:0001993)	2.60170291
30	Abnormality of the labia minora (HP:0012880)	2.53129724
31	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.52106319
32	Cystic liver disease (HP:0006706)	2.51542781
33	Optic nerve hypoplasia (HP:0000609)	2.45910165
34	Abnormality of vitamin B metabolism (HP:0004340)	2.40550260
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.34788538
36	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.34285534
37	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.32116424
38	Abnormality of midbrain morphology (HP:0002418)	2.30991529
39	Molar tooth sign on MRI (HP:0002419)	2.30991529
40	Asplenia (HP:0001746)	2.29897552
41	Abnormality of the costochondral junction (HP:0000919)	2.24295049
42	Hyperventilation (HP:0002883)	2.24272531
43	Small hand (HP:0200055)	2.18887771
44	Hypomagnesemia (HP:0002917)	2.18396901
45	Renal cortical cysts (HP:0000803)	2.17474439
46	Congenital sensorineural hearing impairment (HP:0008527)	2.17063326
47	Abnormal ciliary motility (HP:0012262)	2.15846369
48	Hip dysplasia (HP:0001385)	2.14565848
49	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.12986015
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12268322
51	Hypoglycemic coma (HP:0001325)	2.11497437
52	Ureteral obstruction (HP:0006000)	2.09091229
53	Hypoplasia of the pons (HP:0012110)	2.07717310
54	Abnormality of the 2nd finger (HP:0004100)	2.05993420
55	Occipital encephalocele (HP:0002085)	2.04488420
56	Ureteral stenosis (HP:0000071)	2.03976427
57	Abnormality of the renal medulla (HP:0100957)	2.03425458
58	Supernumerary spleens (HP:0009799)	2.02614920
59	Nephronophthisis (HP:0000090)	2.01976065
60	Febrile seizures (HP:0002373)	2.01368151
61	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.97958382
62	Abolished electroretinogram (ERG) (HP:0000550)	1.97352643
63	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.96063825
64	Abnormal protein N-linked glycosylation (HP:0012347)	1.96063825
65	Abnormal protein glycosylation (HP:0012346)	1.96063825
66	Abnormal glycosylation (HP:0012345)	1.96063825
67	Septo-optic dysplasia (HP:0100842)	1.95991200
68	Polyuria (HP:0000103)	1.94982853
69	Hepatic necrosis (HP:0002605)	1.94674129
70	Lissencephaly (HP:0001339)	1.91961721
71	Decreased circulating renin level (HP:0003351)	1.91680731
72	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.86900674
73	Enlarged kidneys (HP:0000105)	1.86586999
74	Narrow forehead (HP:0000341)	1.86157830
75	Abnormal pancreas size (HP:0012094)	1.85683481
76	Hypoplastic ischia (HP:0003175)	1.81419557
77	Fetal akinesia sequence (HP:0001989)	1.81062544
78	Sclerocornea (HP:0000647)	1.79929926
79	Male pseudohermaphroditism (HP:0000037)	1.79592551
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78431518
81	Decreased central vision (HP:0007663)	1.78204602
82	Generalized hypopigmentation (HP:0007513)	1.77701903
83	Dandy-Walker malformation (HP:0001305)	1.76333403
84	Late onset (HP:0003584)	1.76091023
85	Tubulointerstitial nephritis (HP:0001970)	1.75273014
86	Lipid accumulation in hepatocytes (HP:0006561)	1.74954919
87	Ketosis (HP:0001946)	1.73285061
88	Adrenal hypoplasia (HP:0000835)	1.73042061
89	Hepatocellular necrosis (HP:0001404)	1.72935343
90	Abnormal foot bone ossification (HP:0010675)	1.72583287
91	Iris hypopigmentation (HP:0007730)	1.71357587
92	Dyschromatopsia (HP:0007641)	1.71014148
93	Ocular albinism (HP:0001107)	1.70905860
94	Attenuation of retinal blood vessels (HP:0007843)	1.70667246
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.69859748
96	Furrowed tongue (HP:0000221)	1.66919114
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.66431770
98	Tubular atrophy (HP:0000092)	1.66216926
99	Atonic seizures (HP:0010819)	1.64115805
100	Hypothermia (HP:0002045)	1.63130185

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.81552297
2	TRIM28	4.55945554
3	FRK	4.50406664
4	MAP4K2	3.16478911
5	BRSK2	3.11478132
6	WNK3	2.85282889
7	ADRBK2	2.40798394
8	NUAK1	2.24701145
9	WEE1	2.17820196
10	GRK1	1.79766832
11	TRPM7	1.77039270
12	LMTK2	1.74881812
13	MAPK13	1.67105173
14	TAOK3	1.66960747
15	DYRK2	1.61823693
16	PNCK	1.59040787
17	STK38L	1.54735115
18	ACVR1B	1.52220267
19	MUSK	1.46764090
20	TNIK	1.46131523
21	MAPKAPK3	1.43212045
22	MST4	1.32654614
23	PDK2	1.31986283
24	TXK	1.31492851
25	TIE1	1.31434599
26	PAK3	1.30498000
27	PLK2	1.29676617
28	VRK2	1.22816277
29	TNK2	1.22379957
30	MAP3K9	1.21936254
31	BCR	1.17209071
32	MAP3K12	1.10071910
33	STK39	1.07240025
34	MAPKAPK5	1.04274360
35	BMPR1B	1.02990163
36	OXSR1	0.99415698
37	FER	0.98926106
38	MAP3K3	0.96849203
39	INSRR	0.94446957
40	BRSK1	0.93258373
41	SRPK1	0.93048976
42	PASK	0.91627340
43	PRKCE	0.89601597
44	ERBB3	0.86364385
45	HIPK2	0.82569010
46	STK3	0.82198899
47	PRKD3	0.81964036
48	DAPK2	0.81548625
49	ILK	0.80781090
50	PRKCQ	0.80780843
51	STK24	0.80561310
52	ADRBK1	0.77014954
53	CSNK1G2	0.75519127
54	IRAK1	0.75374144
55	EIF2AK3	0.75036538
56	CSNK1G1	0.71324880
57	PTK2B	0.71314942
58	GRK7	0.71076122
59	WNK4	0.71051948
60	MAP3K7	0.66998693
61	ITK	0.65817118
62	SIK3	0.65673958
63	CSNK1G3	0.61090254
64	VRK1	0.59823554
65	LIMK1	0.58413464
66	BRAF	0.57671125
67	CSNK1A1L	0.56878149
68	NME1	0.54197564
69	KSR1	0.53873468
70	IGF1R	0.53201876
71	EPHA4	0.52789925
72	MARK1	0.51549213
73	ERBB2	0.51341806
74	MKNK2	0.50209800
75	MKNK1	0.49366599
76	PRKCG	0.47499639
77	PRKAA2	0.46909114
78	GSK3A	0.43111269
79	OBSCN	0.43043447
80	PRKCI	0.42791694
81	ROCK1	0.40725214
82	PRKG1	0.40422678
83	TEC	0.38807147
84	INSR	0.38656945
85	AKT3	0.37466430
86	TGFBR2	0.37160769
87	STK11	0.35952190
88	MYLK	0.34888701
89	YES1	0.34461241
90	EPHB1	0.34436767
91	CSNK1A1	0.33687549
92	ARAF	0.33006343
93	PRKCA	0.32255855
94	ATM	0.31136692
95	ZAK	0.30518016
96	PRKCZ	0.29885600
97	CSNK1D	0.29812624
98	TGFBR1	0.28027284
99	PLK3	0.27823039
100	RAF1	0.27423214

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.86120444
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.15320307
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.90204692
4	Phototransduction_Homo sapiens_hsa04744	2.78423192
5	Sulfur metabolism_Homo sapiens_hsa00920	2.68619424
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.68422110
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.60473122
8	Protein export_Homo sapiens_hsa03060	2.54718871
9	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.48303922
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.36423520
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.27719299
12	Propanoate metabolism_Homo sapiens_hsa00640	2.20001894
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.16219538
14	Butanoate metabolism_Homo sapiens_hsa00650	2.15019264
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.14312451
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.81119187
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.80783241
18	Basal transcription factors_Homo sapiens_hsa03022	1.74126439
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.64380463
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.50192325
21	RNA polymerase_Homo sapiens_hsa03020	1.48396922
22	Mineral absorption_Homo sapiens_hsa04978	1.44183568
23	Circadian rhythm_Homo sapiens_hsa04710	1.43891658
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.43804248
25	ABC transporters_Homo sapiens_hsa02010	1.42836115
26	Taste transduction_Homo sapiens_hsa04742	1.42174297
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38828095
28	Olfactory transduction_Homo sapiens_hsa04740	1.35726718
29	Homologous recombination_Homo sapiens_hsa03440	1.31556997
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.30529560
31	Proteasome_Homo sapiens_hsa03050	1.28495514
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.26532848
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.22545363
34	Parkinsons disease_Homo sapiens_hsa05012	1.20077797
35	Regulation of autophagy_Homo sapiens_hsa04140	1.18358891
36	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.17400476
37	Caffeine metabolism_Homo sapiens_hsa00232	1.15924642
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15607869
39	One carbon pool by folate_Homo sapiens_hsa00670	1.10821041
40	Retinol metabolism_Homo sapiens_hsa00830	1.08170875
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06558503
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05967914
43	Peroxisome_Homo sapiens_hsa04146	1.00348807
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.99769265
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96630541
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91644279
47	Morphine addiction_Homo sapiens_hsa05032	0.87571309
48	Sphingolipid metabolism_Homo sapiens_hsa00600	0.86938760
49	RNA transport_Homo sapiens_hsa03013	0.86053992
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85244131
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83756999
52	Alzheimers disease_Homo sapiens_hsa05010	0.83733663
53	Nicotine addiction_Homo sapiens_hsa05033	0.83141477
54	Serotonergic synapse_Homo sapiens_hsa04726	0.82580874
55	Glutathione metabolism_Homo sapiens_hsa00480	0.82065436
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81515276
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79851475
58	RNA degradation_Homo sapiens_hsa03018	0.76865945
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76694377
60	Huntingtons disease_Homo sapiens_hsa05016	0.72916246
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.71730471
62	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.70428405
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.67323009
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.67141727
65	Fatty acid elongation_Homo sapiens_hsa00062	0.66697475
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66292220
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66105755
68	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.64229030
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.64103910
70	Insulin secretion_Homo sapiens_hsa04911	0.63387021
71	Salivary secretion_Homo sapiens_hsa04970	0.62219418
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.58256770
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58206387
74	Metabolic pathways_Homo sapiens_hsa01100	0.54112219
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51021378
76	Purine metabolism_Homo sapiens_hsa00230	0.50751782
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48776643
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48100746
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44398312
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.43774252
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41600602
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39173189
83	Pancreatic secretion_Homo sapiens_hsa04972	0.38765775
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.38524113
85	Circadian entrainment_Homo sapiens_hsa04713	0.36887818
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36470111
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35160997
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34733227
89	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34029959
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.33842704
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.33629594
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.33411605
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.32547841
94	GABAergic synapse_Homo sapiens_hsa04727	0.32114895
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29958213
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.29708776
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.28298232
98	Amphetamine addiction_Homo sapiens_hsa05031	0.28285572
99	Renin secretion_Homo sapiens_hsa04924	0.28088478
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28009058

OR7A19P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »