OR7A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)4.52905156
2piRNA metabolic process (GO:0034587)4.31040231
3retinal cone cell development (GO:0046549)4.30657619
4indolalkylamine metabolic process (GO:0006586)4.08690552
5detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.06682109
6photoreceptor cell maintenance (GO:0045494)4.03245015
7cellular ketone body metabolic process (GO:0046950)3.99208252
8behavioral response to ethanol (GO:0048149)3.77400741
9detection of light stimulus involved in sensory perception (GO:0050962)3.75116476
10detection of light stimulus involved in visual perception (GO:0050908)3.75116476
11neural tube formation (GO:0001841)3.72738019
12establishment of protein localization to Golgi (GO:0072600)3.68430019
13ketone body metabolic process (GO:1902224)3.68363673
14signal peptide processing (GO:0006465)3.68134213
15epithelial cilium movement (GO:0003351)3.65967845
16platelet dense granule organization (GO:0060155)3.62828948
17tachykinin receptor signaling pathway (GO:0007217)3.60564152
18protein-chromophore linkage (GO:0018298)3.55607578
19positive regulation of male gonad development (GO:2000020)3.53629067
20DNA methylation involved in gamete generation (GO:0043046)3.52424688
21regulation of male gonad development (GO:2000018)3.50187916
22indole-containing compound catabolic process (GO:0042436)3.49325527
23indolalkylamine catabolic process (GO:0046218)3.49325527
24tryptophan catabolic process (GO:0006569)3.49325527
25anterograde synaptic vesicle transport (GO:0048490)3.47871827
26regulation of meiosis I (GO:0060631)3.47294904
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31548243
28protein K11-linked deubiquitination (GO:0035871)3.30136713
29protein targeting to Golgi (GO:0000042)3.28382961
30amine catabolic process (GO:0009310)3.27282006
31cellular biogenic amine catabolic process (GO:0042402)3.27282006
32axoneme assembly (GO:0035082)3.26139659
33cullin deneddylation (GO:0010388)3.23447988
34reciprocal DNA recombination (GO:0035825)3.18959094
35reciprocal meiotic recombination (GO:0007131)3.18959094
36inner ear receptor stereocilium organization (GO:0060122)3.13538070
37cilium movement (GO:0003341)3.08860154
38dopamine transport (GO:0015872)3.03897291
39auditory receptor cell stereocilium organization (GO:0060088)3.03137370
40protein prenylation (GO:0018342)3.02970246
41prenylation (GO:0097354)3.02970246
42tryptophan metabolic process (GO:0006568)3.01990292
43retrograde transport, vesicle recycling within Golgi (GO:0000301)2.99202700
44heparin biosynthetic process (GO:0030210)2.97440401
45heparin metabolic process (GO:0030202)2.97440401
46keratinocyte development (GO:0003334)2.96267911
47indole-containing compound metabolic process (GO:0042430)2.95395406
48multicellular organism reproduction (GO:0032504)2.90099024
49protein polyglutamylation (GO:0018095)2.86259189
50respiratory chain complex IV assembly (GO:0008535)2.85043139
51protein deneddylation (GO:0000338)2.84040355
52kynurenine metabolic process (GO:0070189)2.83066461
53synapsis (GO:0007129)2.82125909
54cellular response to sterol (GO:0036315)2.81899329
55C4-dicarboxylate transport (GO:0015740)2.80972683
56cilium morphogenesis (GO:0060271)2.80822671
57protein localization to Golgi apparatus (GO:0034067)2.80264766
58proline transport (GO:0015824)2.79791525
59amino acid salvage (GO:0043102)2.79738497
60L-methionine salvage (GO:0071267)2.79738497
61L-methionine biosynthetic process (GO:0071265)2.79738497
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77050505
63opioid receptor signaling pathway (GO:0038003)2.76860782
64meiotic chromosome segregation (GO:0045132)2.76176578
65male meiosis (GO:0007140)2.74826601
66transmission of nerve impulse (GO:0019226)2.74254616
67negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73234831
68intraciliary transport (GO:0042073)2.71321078
69regulation of collateral sprouting (GO:0048670)2.70966612
70S-adenosylmethionine metabolic process (GO:0046500)2.69792953
71rhodopsin mediated signaling pathway (GO:0016056)2.68151470
72DNA double-strand break processing (GO:0000729)2.67177599
73regulation of acrosome reaction (GO:0060046)2.66443758
74regulation of cilium movement (GO:0003352)2.65817546
75cilium organization (GO:0044782)2.65416626
76response to pheromone (GO:0019236)2.64516276
77transcription from mitochondrial promoter (GO:0006390)2.64499316
78anterograde axon cargo transport (GO:0008089)2.64335391
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62311568
80regulation of female gonad development (GO:2000194)2.60631308
81cilium assembly (GO:0042384)2.60525437
82DNA integration (GO:0015074)2.59759723
83L-fucose metabolic process (GO:0042354)2.59547158
84L-fucose catabolic process (GO:0042355)2.59547158
85fucose catabolic process (GO:0019317)2.59547158
86detection of mechanical stimulus involved in sensory perception (GO:0050974)2.59015642
87serotonin metabolic process (GO:0042428)2.58800219
88cell wall macromolecule catabolic process (GO:0016998)2.58552123
89regulation of female receptivity (GO:0045924)2.58385931
90cornea development in camera-type eye (GO:0061303)2.57957409
91transepithelial transport (GO:0070633)2.57252980
92visual perception (GO:0007601)2.54145001
93double-strand break repair via homologous recombination (GO:0000724)2.53686549
94methionine metabolic process (GO:0006555)2.52690778
95sensory perception of light stimulus (GO:0050953)2.52582865
96aromatic amino acid family metabolic process (GO:0009072)2.52105207
97* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.51339172
98acrosome assembly (GO:0001675)2.51241787
99cytochrome complex assembly (GO:0017004)2.50978395
100regulation of gonadotropin secretion (GO:0032276)2.49188256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.44801463
2GBX2_23144817_ChIP-Seq_PC3_Human3.29908575
3ZNF274_21170338_ChIP-Seq_K562_Hela3.10644208
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86087340
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85542189
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55438869
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.51481270
8VDR_22108803_ChIP-Seq_LS180_Human2.51189885
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44783692
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43436618
11P300_19829295_ChIP-Seq_ESCs_Human2.35298353
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28802865
13FUS_26573619_Chip-Seq_HEK293_Human2.18273361
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17730453
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16071116
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13545697
17EWS_26573619_Chip-Seq_HEK293_Human2.13222701
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09438015
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.00012398
20ER_23166858_ChIP-Seq_MCF-7_Human1.98154138
21TAF15_26573619_Chip-Seq_HEK293_Human1.93010926
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.91791393
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87358626
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83119448
25EZH2_22144423_ChIP-Seq_EOC_Human1.82329256
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82002061
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79747995
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.79504110
29SMAD4_21799915_ChIP-Seq_A2780_Human1.79375754
30STAT3_23295773_ChIP-Seq_U87_Human1.77332817
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.71421350
32TCF4_23295773_ChIP-Seq_U87_Human1.65249145
33BCAT_22108803_ChIP-Seq_LS180_Human1.64725781
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.64470791
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.61651056
36CBP_20019798_ChIP-Seq_JUKART_Human1.59648925
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59648925
38NANOG_19829295_ChIP-Seq_ESCs_Human1.56451378
39SOX2_19829295_ChIP-Seq_ESCs_Human1.56451378
40AR_25329375_ChIP-Seq_VCAP_Human1.55488007
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52429571
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50462174
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.48934596
44TP53_22573176_ChIP-Seq_HFKS_Human1.47628785
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47247030
46TCF4_22108803_ChIP-Seq_LS180_Human1.47131484
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45754605
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.45342467
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.42743236
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40290490
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39138536
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37928985
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37928985
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.36937490
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35476864
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35322305
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35265471
58RUNX2_22187159_ChIP-Seq_PCA_Human1.34279727
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.33762208
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32108928
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31762931
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30913115
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.28667762
64AR_21572438_ChIP-Seq_LNCaP_Human1.27880881
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27747121
66CDX2_22108803_ChIP-Seq_LS180_Human1.27572677
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27234292
68P53_22387025_ChIP-Seq_ESCs_Mouse1.24743194
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24559452
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23948081
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.22984967
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21803724
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.20572451
74P300_18555785_Chip-Seq_ESCs_Mouse1.16812664
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.15409020
76IRF1_19129219_ChIP-ChIP_H3396_Human1.15042533
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.14886767
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14812353
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14775702
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13276109
81GABP_17652178_ChIP-ChIP_JURKAT_Human1.12422856
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12274689
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11728960
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10994847
85ELK1_19687146_ChIP-ChIP_HELA_Human1.09937867
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.07313632
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07313632
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.07017943
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.05819111
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.05416651
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05024195
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04616720
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.04139439
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03816130
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02321094
96* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01298091
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01038233
98CTCF_18555785_Chip-Seq_ESCs_Mouse1.00290203
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00071180
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98182333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.97016572
2MP0008877_abnormal_DNA_methylation3.96402508
3MP0000372_irregular_coat_pigmentation3.57493291
4MP0003136_yellow_coat_color3.44446805
5MP0005551_abnormal_eye_electrophysiolog2.94207832
6MP0005253_abnormal_eye_physiology2.73519814
7MP0003880_abnormal_central_pattern2.63715203
8MP0006072_abnormal_retinal_apoptosis2.52303152
9MP0003195_calcinosis2.44182595
10MP0006276_abnormal_autonomic_nervous2.18008168
11MP0002638_abnormal_pupillary_reflex2.12118583
12MP0001501_abnormal_sleep_pattern1.95919354
13MP0002102_abnormal_ear_morphology1.95285456
14MP0005410_abnormal_fertilization1.82160413
15MP0000015_abnormal_ear_pigmentation1.80881433
16MP0003950_abnormal_plasma_membrane1.80565908
17MP0001764_abnormal_homeostasis1.76965528
18MP0005171_absent_coat_pigmentation1.75591283
19MP0008058_abnormal_DNA_repair1.71868257
20MP0002095_abnormal_skin_pigmentation1.67204044
21MP0003718_maternal_effect1.64214474
22MP0000427_abnormal_hair_cycle1.60755230
23MP0001968_abnormal_touch/_nociception1.58831227
24MP0005670_abnormal_white_adipose1.58563192
25MP0005174_abnormal_tail_pigmentation1.56964767
26MP0009046_muscle_twitch1.51569683
27MP0003011_delayed_dark_adaptation1.50882793
28MP0000538_abnormal_urinary_bladder1.44340560
29MP0001485_abnormal_pinna_reflex1.43616402
30MP0005085_abnormal_gallbladder_physiolo1.42197242
31MP0003698_abnormal_male_reproductive1.38298049
32MP0005310_abnormal_salivary_gland1.37126727
33MP0010386_abnormal_urinary_bladder1.36637123
34MP0001929_abnormal_gametogenesis1.36341321
35MP0003646_muscle_fatigue1.36008062
36MP0002736_abnormal_nociception_after1.35773407
37MP0001986_abnormal_taste_sensitivity1.34637322
38MP0009745_abnormal_behavioral_response1.34294012
39MP0005365_abnormal_bile_salt1.33919758
40MP0005075_abnormal_melanosome_morpholog1.33276744
41MP0001486_abnormal_startle_reflex1.33199451
42MP0008872_abnormal_physiological_respon1.27890464
43MP0000647_abnormal_sebaceous_gland1.26786824
44MP0002090_abnormal_vision1.26610545
45MP0001984_abnormal_olfaction1.25099984
46MP0002928_abnormal_bile_duct1.25026985
47MP0002938_white_spotting1.23674482
48MP0005083_abnormal_biliary_tract1.22275293
49MP0000383_abnormal_hair_follicle1.21886082
50MP0001529_abnormal_vocalization1.21205475
51MP0002160_abnormal_reproductive_system1.16188673
52MP0000631_abnormal_neuroendocrine_gland1.13501284
53MP0005084_abnormal_gallbladder_morpholo1.12660282
54MP0003787_abnormal_imprinting1.09768167
55MP0005187_abnormal_penis_morphology1.09170548
56MP0004215_abnormal_myocardial_fiber1.08648457
57MP0000653_abnormal_sex_gland1.08112538
58MP0002909_abnormal_adrenal_gland1.07892471
59MP0002210_abnormal_sex_determination1.07854675
60MP0008057_abnormal_DNA_replication1.07181799
61MP0002272_abnormal_nervous_system1.07064820
62MP0002229_neurodegeneration1.06241369
63MP0005646_abnormal_pituitary_gland1.05292665
64MP0009697_abnormal_copulation1.03504903
65MP0008995_early_reproductive_senescence1.02656126
66MP0005395_other_phenotype1.01705261
67MP0005408_hypopigmentation1.01634456
68MP0005379_endocrine/exocrine_gland_phen1.01440497
69MP0005391_vision/eye_phenotype0.98695223
70MP0001145_abnormal_male_reproductive0.95080929
71MP0006292_abnormal_olfactory_placode0.94376266
72MP0006036_abnormal_mitochondrial_physio0.92707276
73MP0003252_abnormal_bile_duct0.91599372
74MP0004145_abnormal_muscle_electrophysio0.91019421
75MP0003943_abnormal_hepatobiliary_system0.90433174
76MP0003045_fibrosis0.90274122
77MP0005195_abnormal_posterior_eye0.89121424
78MP0002557_abnormal_social/conspecific_i0.88723344
79MP0001324_abnormal_eye_pigmentation0.83945733
80MP0005386_behavior/neurological_phenoty0.83859753
81MP0004924_abnormal_behavior0.83859753
82MP0002067_abnormal_sensory_capabilities0.82549196
83MP0008875_abnormal_xenobiotic_pharmacok0.82449998
84MP0005389_reproductive_system_phenotype0.82208777
85MP0002168_other_aberrant_phenotype0.82198118
86MP0002751_abnormal_autonomic_nervous0.81726052
87MP0002132_abnormal_respiratory_system0.81670790
88MP0001970_abnormal_pain_threshold0.81649237
89MP0002282_abnormal_trachea_morphology0.80753204
90MP0001756_abnormal_urination0.80166517
91MP0003806_abnormal_nucleotide_metabolis0.79543268
92MP0008775_abnormal_heart_ventricle0.77982720
93MP0009780_abnormal_chondrocyte_physiolo0.76928869
94MP0005167_abnormal_blood-brain_barrier0.76652594
95MP0002572_abnormal_emotion/affect_behav0.75296349
96MP0002876_abnormal_thyroid_physiology0.75026865
97MP0003121_genomic_imprinting0.74212512
98MP0001963_abnormal_hearing_physiology0.72456040
99MP0001119_abnormal_female_reproductive0.72291027
100MP0004142_abnormal_muscle_tone0.72202999

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.65205896
2Pancreatic cysts (HP:0001737)4.04522333
3Molar tooth sign on MRI (HP:0002419)3.85659976
4Abnormality of midbrain morphology (HP:0002418)3.85659976
5Attenuation of retinal blood vessels (HP:0007843)3.81952594
6Abnormal biliary tract physiology (HP:0012439)3.59313012
7Bile duct proliferation (HP:0001408)3.59313012
8Pancreatic fibrosis (HP:0100732)3.49078116
9Chronic hepatic failure (HP:0100626)3.29073671
10Abolished electroretinogram (ERG) (HP:0000550)3.19277996
11Bony spicule pigmentary retinopathy (HP:0007737)3.13371934
12Gaze-evoked nystagmus (HP:0000640)3.00541992
13Congenital stationary night blindness (HP:0007642)2.96530783
14Medial flaring of the eyebrow (HP:0010747)2.92087390
15Abnormality of macular pigmentation (HP:0008002)2.81185785
16Progressive inability to walk (HP:0002505)2.78175676
17Nephronophthisis (HP:0000090)2.77334435
18Hyperventilation (HP:0002883)2.71700485
19Abnormality of the renal cortex (HP:0011035)2.70002137
20Abnormal rod and cone electroretinograms (HP:0008323)2.67454690
21Gonadal dysgenesis (HP:0000133)2.61276677
22Abnormality of the renal medulla (HP:0100957)2.53171422
23Cystic liver disease (HP:0006706)2.48830504
24Male pseudohermaphroditism (HP:0000037)2.45433432
25Type II lissencephaly (HP:0007260)2.44097472
26Tubulointerstitial nephritis (HP:0001970)2.42707688
27Cerebellar dysplasia (HP:0007033)2.42641273
28Glioma (HP:0009733)2.32680963
29Severe visual impairment (HP:0001141)2.30662924
30Chromsome breakage (HP:0040012)2.29742788
31Congenital sensorineural hearing impairment (HP:0008527)2.27651126
32Congenital primary aphakia (HP:0007707)2.27268091
33Volvulus (HP:0002580)2.26649684
34Gait imbalance (HP:0002141)2.25716908
35Stomach cancer (HP:0012126)2.24143712
36Albinism (HP:0001022)2.22584519
37Amyotrophic lateral sclerosis (HP:0007354)2.21465829
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.21295433
39Hypoplasia of the fovea (HP:0007750)2.21295433
40Fair hair (HP:0002286)2.20918269
41Renal cortical cysts (HP:0000803)2.20382527
42Increased CSF lactate (HP:0002490)2.17915545
43Retinal dysplasia (HP:0007973)2.16617019
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16612822
45Absent speech (HP:0001344)2.16302621
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.14226331
47Abnormality of the fovea (HP:0000493)2.12259010
48Focal seizures (HP:0007359)2.09098771
49Gonadotropin excess (HP:0000837)2.08620123
50Intestinal atresia (HP:0011100)2.07952912
51Abnormality of the astrocytes (HP:0100707)2.07546949
52Astrocytoma (HP:0009592)2.07546949
53Inability to walk (HP:0002540)2.05552103
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.05220280
55Constricted visual fields (HP:0001133)2.04327528
56Tubular atrophy (HP:0000092)2.03468382
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.03446020
58Furrowed tongue (HP:0000221)1.99496269
59Nephrogenic diabetes insipidus (HP:0009806)1.98582462
60Tubulointerstitial abnormality (HP:0001969)1.97886116
61Febrile seizures (HP:0002373)1.95961047
62Generalized hypopigmentation of hair (HP:0011358)1.94697515
63Hemiparesis (HP:0001269)1.94484731
64Central scotoma (HP:0000603)1.92995666
65Hypothermia (HP:0002045)1.91272325
66Abnormality of chromosome stability (HP:0003220)1.90462213
67Bifid tongue (HP:0010297)1.90275551
68Genital tract atresia (HP:0001827)1.89074727
69Keratoconus (HP:0000563)1.87810800
70Increased corneal curvature (HP:0100692)1.87810800
71Congenital hepatic fibrosis (HP:0002612)1.86056765
72Sclerocornea (HP:0000647)1.84261869
73Vaginal atresia (HP:0000148)1.84190957
74Anencephaly (HP:0002323)1.83562590
75Type I transferrin isoform profile (HP:0003642)1.82602163
76Colon cancer (HP:0003003)1.81725899
77Progressive macrocephaly (HP:0004481)1.81258929
78Optic disc pallor (HP:0000543)1.80226911
79Oculomotor apraxia (HP:0000657)1.79898061
80Clumsiness (HP:0002312)1.79528477
81Ketoacidosis (HP:0001993)1.79101033
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78110965
83Photophobia (HP:0000613)1.77884622
84Postaxial foot polydactyly (HP:0001830)1.75405203
85Astigmatism (HP:0000483)1.74754659
86Sloping forehead (HP:0000340)1.74686297
87Medulloblastoma (HP:0002885)1.74577603
88Pancreatic islet-cell hyperplasia (HP:0004510)1.74428620
89Broad-based gait (HP:0002136)1.73939410
90Hyperglycinuria (HP:0003108)1.73576684
91Acute encephalopathy (HP:0006846)1.72320483
92Pendular nystagmus (HP:0012043)1.72137665
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71758809
94Acute necrotizing encephalopathy (HP:0006965)1.71569320
95Abnormality of the labia minora (HP:0012880)1.70302253
96Dialeptic seizures (HP:0011146)1.69314569
97Papillary thyroid carcinoma (HP:0002895)1.68785423
98Focal motor seizures (HP:0011153)1.67873636
99Abnormality of the ileum (HP:0001549)1.67496860
100Abnormal drinking behavior (HP:0030082)1.67385243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.03436698
2PDK23.05185868
3ADRBK22.85630997
4TRIM282.82387368
5PIK3CG2.76039262
6NUAK12.57589029
7MUSK2.29679397
8EIF2AK32.19604489
9ZAK2.19567904
10INSRR2.03372844
11BMPR1B2.02609789
12WNK31.99873056
13GRK11.99123257
14PINK11.98552289
15ACVR1B1.98079044
16CASK1.90740236
17MAP4K21.83092457
18MAP3K41.70921337
19STK38L1.66455110
20OXSR11.65048212
21MST41.62335663
22TNIK1.58714926
23BCR1.45854007
24MAP2K71.36867367
25STK391.33341967
26PBK1.32932827
27NTRK31.31438860
28MAPK131.24276114
29PLK21.24020721
30PAK31.14888839
31MKNK21.14506619
32MAP3K121.12617657
33SIK31.10297591
34CSNK1G11.08917781
35EPHA40.97315691
36PTK2B0.94101413
37PRKCE0.93763568
38BRSK20.91475827
39VRK10.90666508
40PNCK0.89614169
41ERBB30.88425766
42DAPK20.87993697
43PLK40.87536095
44ADRBK10.86228897
45CSNK1G20.84296437
46PLK30.84171850
47CSNK1G30.83843133
48PKN10.79089518
49NME10.79050048
50STK30.77957625
51DYRK30.77798824
52CSNK1A1L0.77749553
53TAOK30.72646176
54FER0.70666817
55MKNK10.69153649
56DYRK1A0.68907014
57MARK10.65470845
58PRKCG0.65154376
59TNK20.61865115
60LATS10.61769389
61MINK10.58477174
62NEK60.57075474
63TLK10.54816382
64CAMK2A0.51470800
65BCKDK0.51454699
66NLK0.48688028
67FGFR20.47997321
68TXK0.41835292
69ATM0.41039946
70PRKACA0.40957258
71TGFBR10.39122965
72IKBKB0.38962252
73DYRK20.37774830
74CSNK1D0.37462538
75CAMKK20.36837364
76PRKAA20.36329636
77CSNK1A10.35355472
78ROCK10.35068631
79AKT30.34445704
80KIT0.34122985
81PLK10.33115783
82BRD40.32856857
83PIK3CA0.32775177
84PRKCI0.32413230
85TEC0.31643104
86MYLK0.31277382
87MARK30.31172032
88PRKG10.30258103
89PRKACG0.29403862
90WEE10.28924343
91PRKCQ0.28455625
92PRKCA0.27651302
93PRKACB0.27146623
94DAPK10.23593529
95PRKAA10.23548023
96PIM20.22981246
97IRAK10.22426918
98ABL10.22308345
99MAP2K10.22008732
100EIF2AK10.21939989

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.13315781
2Butanoate metabolism_Homo sapiens_hsa006503.07605513
3Phototransduction_Homo sapiens_hsa047442.84308084
4Nitrogen metabolism_Homo sapiens_hsa009102.48143036
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.45674083
6Homologous recombination_Homo sapiens_hsa034402.44633719
7Tryptophan metabolism_Homo sapiens_hsa003802.21527662
8Linoleic acid metabolism_Homo sapiens_hsa005912.20621178
9Fanconi anemia pathway_Homo sapiens_hsa034602.20328632
10Non-homologous end-joining_Homo sapiens_hsa034502.18648311
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10354790
12Propanoate metabolism_Homo sapiens_hsa006402.06726359
13* Olfactory transduction_Homo sapiens_hsa047401.96415386
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95763037
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95167329
16Protein export_Homo sapiens_hsa030601.90060745
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87946223
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77361637
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75416700
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73381386
21Basal transcription factors_Homo sapiens_hsa030221.63057363
22Nicotine addiction_Homo sapiens_hsa050331.55812307
23Ether lipid metabolism_Homo sapiens_hsa005651.55150779
24ABC transporters_Homo sapiens_hsa020101.52884325
25Regulation of autophagy_Homo sapiens_hsa041401.51306150
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47466990
27RNA polymerase_Homo sapiens_hsa030201.43668566
28Proteasome_Homo sapiens_hsa030501.38869140
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.38715563
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37902029
31Taste transduction_Homo sapiens_hsa047421.35619902
32beta-Alanine metabolism_Homo sapiens_hsa004101.33085589
33Chemical carcinogenesis_Homo sapiens_hsa052041.32549226
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27999702
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23210394
36Circadian rhythm_Homo sapiens_hsa047101.23008068
37RNA degradation_Homo sapiens_hsa030181.22433787
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22154341
39Selenocompound metabolism_Homo sapiens_hsa004501.19448698
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12494748
41Caffeine metabolism_Homo sapiens_hsa002321.06080165
42Retinol metabolism_Homo sapiens_hsa008301.05969176
43Arachidonic acid metabolism_Homo sapiens_hsa005901.02102189
44Glycerolipid metabolism_Homo sapiens_hsa005611.00227597
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99327511
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94476834
47Peroxisome_Homo sapiens_hsa041460.91166506
48Morphine addiction_Homo sapiens_hsa050320.89674963
49Dorso-ventral axis formation_Homo sapiens_hsa043200.89168971
50Collecting duct acid secretion_Homo sapiens_hsa049660.87915666
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83776998
52One carbon pool by folate_Homo sapiens_hsa006700.82884155
53Sphingolipid metabolism_Homo sapiens_hsa006000.82035862
54Salivary secretion_Homo sapiens_hsa049700.80833015
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79353367
56Oxidative phosphorylation_Homo sapiens_hsa001900.78536102
57Fat digestion and absorption_Homo sapiens_hsa049750.76742508
58GABAergic synapse_Homo sapiens_hsa047270.74655185
59Arginine and proline metabolism_Homo sapiens_hsa003300.73369242
60Circadian entrainment_Homo sapiens_hsa047130.73367721
61Huntingtons disease_Homo sapiens_hsa050160.73035593
62Glutathione metabolism_Homo sapiens_hsa004800.72847598
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72414606
64Metabolic pathways_Homo sapiens_hsa011000.71977024
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71784985
66Hedgehog signaling pathway_Homo sapiens_hsa043400.69951417
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68896037
68Histidine metabolism_Homo sapiens_hsa003400.68125110
69Parkinsons disease_Homo sapiens_hsa050120.67936543
70Lysine degradation_Homo sapiens_hsa003100.66035182
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.64053068
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.63832215
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63760638
74Purine metabolism_Homo sapiens_hsa002300.63517717
75Inositol phosphate metabolism_Homo sapiens_hsa005620.62102969
76Fatty acid degradation_Homo sapiens_hsa000710.58214877
77Calcium signaling pathway_Homo sapiens_hsa040200.58214334
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57532858
79Fatty acid elongation_Homo sapiens_hsa000620.53786558
80Serotonergic synapse_Homo sapiens_hsa047260.51848828
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49463514
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48672175
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48204187
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.46944687
85Steroid biosynthesis_Homo sapiens_hsa001000.45523997
86Insulin secretion_Homo sapiens_hsa049110.45018491
87Glutamatergic synapse_Homo sapiens_hsa047240.44900680
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37990976
89Mineral absorption_Homo sapiens_hsa049780.36615534
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36173841
91Ovarian steroidogenesis_Homo sapiens_hsa049130.35664310
92RNA transport_Homo sapiens_hsa030130.34481772
93Asthma_Homo sapiens_hsa053100.33385782
94Pancreatic secretion_Homo sapiens_hsa049720.32010126
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28998957
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28996548
97TGF-beta signaling pathway_Homo sapiens_hsa043500.28350647
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.27779094
99Pyruvate metabolism_Homo sapiens_hsa006200.27418469
100Vitamin B6 metabolism_Homo sapiens_hsa007500.26581019

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