ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.80122293
2	DNA packaging (GO:0006323)	9.37677234
3	sperm capacitation (GO:0048240)	9.13813097
4	response to pheromone (GO:0019236)	9.06324439
5	single strand break repair (GO:0000012)	8.97762927
6	spermatid nucleus differentiation (GO:0007289)	8.95050659
7	spermatid development (GO:0007286)	8.79605675
8	plasma membrane fusion (GO:0045026)	8.03991764
9	sperm-egg recognition (GO:0035036)	7.93666292
10	binding of sperm to zona pellucida (GO:0007339)	7.87132791
11	microtubule depolymerization (GO:0007019)	7.52279283
12	multicellular organism reproduction (GO:0032504)	7.36208055
13	sexual reproduction (GO:0019953)	7.35233205
14	negative regulation of inclusion body assembly (GO:0090084)	7.13858884
15	reproduction (GO:0000003)	7.10199647
16	rRNA methylation (GO:0031167)	6.94160744
17	calcium ion-dependent exocytosis (GO:0017156)	6.61075327
18	axonemal dynein complex assembly (GO:0070286)	6.56853916
19	cell-cell recognition (GO:0009988)	6.53643849
20	protein polyglutamylation (GO:0018095)	6.41665230
21	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.22275103
22	spermatogenesis (GO:0007283)	6.14213585
23	male gamete generation (GO:0048232)	6.12033033
24	microtubule polymerization or depolymerization (GO:0031109)	6.09465286
25	protein targeting to Golgi (GO:0000042)	6.04606700
26	microtubule severing (GO:0051013)	5.97815188
27	rRNA modification (GO:0000154)	5.90405437
28	establishment of protein localization to Golgi (GO:0072600)	5.77086941
29	phosphatidylethanolamine metabolic process (GO:0046337)	5.72568422
30	gamete generation (GO:0007276)	5.61112131
31	motile cilium assembly (GO:0044458)	5.58637758
32	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.58440670
33	cellular ketone body metabolic process (GO:0046950)	5.50044280
34	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.30361532
35	germ cell development (GO:0007281)	5.29959113
36	single fertilization (GO:0007338)	5.12963599
37	chromatin silencing (GO:0006342)	5.07415873
38	regulation of inclusion body assembly (GO:0090083)	5.07097080
39	centriole replication (GO:0007099)	4.92318607
40	regulation of cilium movement (GO:0003352)	4.90856048
41	regulation of Rab GTPase activity (GO:0032313)	4.88473629
42	positive regulation of Rab GTPase activity (GO:0032851)	4.88473629
43	cilium or flagellum-dependent cell motility (GO:0001539)	4.88388746
44	ketone body metabolic process (GO:1902224)	4.86401781
45	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.83976051
46	centriole assembly (GO:0098534)	4.51495843
47	multicellular organismal reproductive process (GO:0048609)	4.50867915
48	nucleosome disassembly (GO:0006337)	4.49592201
49	protein-DNA complex disassembly (GO:0032986)	4.49592201
50	protein localization to Golgi apparatus (GO:0034067)	4.40050014
51	regulation of transcription involved in cell fate commitment (GO:0060850)	4.32120438
52	coenzyme catabolic process (GO:0009109)	4.29641277
53	epithelial cilium movement (GO:0003351)	4.25085491
54	nucleus organization (GO:0006997)	4.22891132
55	fertilization (GO:0009566)	4.18638753
56	RNA destabilization (GO:0050779)	4.13660944
57	regulation of centriole replication (GO:0046599)	4.09766829
58	cell wall macromolecule catabolic process (GO:0016998)	4.06659881
59	cell wall macromolecule metabolic process (GO:0044036)	4.01485696
60	organic cation transport (GO:0015695)	3.90714035
61	polyamine biosynthetic process (GO:0006596)	3.88677663
62	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.83054661
63	histone H3-K9 demethylation (GO:0033169)	3.74549539
64	male meiosis (GO:0007140)	3.72537156
65	cilium movement (GO:0003341)	3.71178583
66	response to acidic pH (GO:0010447)	3.68845391
67	negative regulation of Rho protein signal transduction (GO:0035024)	3.68281441
68	regulation of meiosis I (GO:0060631)	3.67459210
69	seminiferous tubule development (GO:0072520)	3.60587744
70	glycerol ether metabolic process (GO:0006662)	3.58572233
71	negative regulation of gene expression, epigenetic (GO:0045814)	3.48471945
72	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.31285263
73	histone exchange (GO:0043486)	3.30377720
74	ether metabolic process (GO:0018904)	3.30127978
75	regulation of microtubule-based movement (GO:0060632)	3.27782996
76	cellular response to pH (GO:0071467)	3.26910100
77	piRNA metabolic process (GO:0034587)	3.22124839
78	multicellular organismal movement (GO:0050879)	3.21581861
79	musculoskeletal movement (GO:0050881)	3.21581861
80	cranial nerve morphogenesis (GO:0021602)	3.14051016
81	cell recognition (GO:0008037)	3.13656185
82	regulation of interleukin-13 production (GO:0032656)	3.11501457
83	DNA conformation change (GO:0071103)	3.09449197
84	cerebral cortex neuron differentiation (GO:0021895)	3.08559097
85	multicellular organismal development (GO:0007275)	3.06383025
86	peptidyl-threonine dephosphorylation (GO:0035970)	3.05339405
87	male sex determination (GO:0030238)	3.00810091
88	male meiosis I (GO:0007141)	2.94463635
89	regulation of T-helper 2 cell differentiation (GO:0045628)	2.90839678
90	protein depolymerization (GO:0051261)	2.88979787
91	homeostasis of number of cells within a tissue (GO:0048873)	2.87347533
92	microtubule nucleation (GO:0007020)	2.86663924
93	regulation of ARF GTPase activity (GO:0032312)	2.84883662
94	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.83085281
95	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.83085281
96	receptor recycling (GO:0001881)	2.81927392
97	glomerular visceral epithelial cell development (GO:0072015)	2.79498340
98	acrosome reaction (GO:0007340)	12.7887551
99	sperm motility (GO:0030317)	12.0218612
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.5733667

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.52609116
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.58823595
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.21101867
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54785100
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.54785100
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.48434873
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35912477
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.26077829
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.26077829
10	ERA_21632823_ChIP-Seq_H3396_Human	2.20106458
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17482779
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.10013556
13	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.03993843
14	WDR5_24793694_ChIP-Seq_LNCAP_Human	2.02546453
15	FUS_26573619_Chip-Seq_HEK293_Human	2.02459414
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.01334746
17	RAC3_21632823_ChIP-Seq_H3396_Human	2.00957972
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.97925755
19	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.92952802
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90831501
21	CTCF_27219007_Chip-Seq_Bcells_Human	1.90177323
22	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.89026047
23	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.88884252
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.78944703
25	SMC4_20622854_ChIP-Seq_HELA_Human	1.76503031
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.74400292
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.70405126
28	MYC_19829295_ChIP-Seq_ESCs_Human	1.67404184
29	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.66967139
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.66529593
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66328562
32	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.65517944
33	PHF8_20622854_ChIP-Seq_HELA_Human	1.62857751
34	E2F1_20622854_ChIP-Seq_HELA_Human	1.62813931
35	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.61849911
36	P68_20966046_ChIP-Seq_HELA_Human	1.60700205
37	DROSHA_22980978_ChIP-Seq_HELA_Human	1.60268049
38	CTCF_20526341_ChIP-Seq_ESCs_Human	1.59528390
39	OCT4_20526341_ChIP-Seq_ESCs_Human	1.58928967
40	BCOR_27268052_Chip-Seq_Bcells_Human	1.55341210
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.51920569
42	TP63_22573176_ChIP-Seq_HFKS_Human	1.51884122
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51524455
44	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.49379979
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.48353386
46	P300_27268052_Chip-Seq_Bcells_Human	1.47612740
47	AR_25329375_ChIP-Seq_VCAP_Human	1.47313150
48	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.41973319
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41645932
50	ERG_20517297_ChIP-Seq_VCAP_Human	1.40488088
51	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.39021740
52	LXR_22292898_ChIP-Seq_THP-1_Human	1.39009179
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38086307
54	TP53_18474530_ChIP-ChIP_U2OS_Human	1.38005515
55	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.37454971
56	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.36754514
57	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.36032658
58	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.35576158
59	RBPJ_21746931_ChIP-Seq_IB4_Human	1.33200297
60	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.32735957
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32515609
62	P300_19829295_ChIP-Seq_ESCs_Human	1.31394128
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30673354
64	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.28833962
65	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28647844
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.28265186
67	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.27819555
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27251715
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.25996575
70	TBL1_22424771_ChIP-Seq_293T_Human	1.25705357
71	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.24118559
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23191767
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19855759
74	CEBPB_22108803_ChIP-Seq_LS180_Human	1.19500141
75	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.19229958
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19080233
77	NFYB_21822215_ChIP-Seq_K562_Human	1.17886881
78	TAF15_26573619_Chip-Seq_HEK293_Human	1.17535162
79	AR_21572438_ChIP-Seq_LNCaP_Human	1.16946669
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16903979
81	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.14871226
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13032897
83	PHF8_20622853_ChIP-Seq_HELA_Human	1.12005854
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.09484114
85	SMRT_27268052_Chip-Seq_Bcells_Human	1.09321611
86	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.08716768
87	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.08290501
88	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08052967
89	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08010577
90	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08010577
91	SA1_27219007_Chip-Seq_Bcells_Human	1.07367341
92	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.06992311
93	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.06746753
94	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05131302
95	OCT4_19829295_ChIP-Seq_ESCs_Human	1.01684712
96	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.01336512
97	ZNF274_21170338_ChIP-Seq_K562_Hela	1.01239217
98	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00150793
99	GF1_26923725_Chip-Seq_HPCs_Mouse	1.00118710
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99936403

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	4.76052172
2	MP0005377_hearing/vestibular/ear_phenot	4.53598800
3	MP0003878_abnormal_ear_physiology	4.53598800
4	MP0001929_abnormal_gametogenesis	4.18960665
5	MP0005670_abnormal_white_adipose	4.13618460
6	MP0001348_abnormal_lacrimal_gland	3.62735521
7	MP0000678_abnormal_parathyroid_gland	2.72204623
8	MP0002161_abnormal_fertility/fecundity	2.61384271
9	MP0002132_abnormal_respiratory_system	2.27680516
10	MP0003718_maternal_effect	2.22579741
11	MP0003011_delayed_dark_adaptation	2.08000912
12	MP0002210_abnormal_sex_determination	2.02873244
13	MP0005410_abnormal_fertilization	13.0750792
14	MP0002249_abnormal_larynx_morphology	1.78055652
15	MP0005379_endocrine/exocrine_gland_phen	1.77724718
16	MP0001145_abnormal_male_reproductive	1.68528074
17	MP0003646_muscle_fatigue	1.60432581
18	MP0000653_abnormal_sex_gland	1.56724095
19	MP0002282_abnormal_trachea_morphology	1.48516534
20	MP0009053_abnormal_anal_canal	1.40328221
21	MP0005423_abnormal_somatic_nervous	1.38675102
22	MP0005248_abnormal_Harderian_gland	1.37852106
23	MP0001485_abnormal_pinna_reflex	1.33252340
24	MP0001486_abnormal_startle_reflex	1.30524675
25	MP0001968_abnormal_touch/_nociception	1.25316191
26	MP0002234_abnormal_pharynx_morphology	1.22511893
27	MP0002127_abnormal_cardiovascular_syste	1.21220354
28	MP0002735_abnormal_chemical_nociception	1.17184957
29	MP0000534_abnormal_ureter_morphology	1.14298837
30	MP0004742_abnormal_vestibular_system	1.09647059
31	MP0002138_abnormal_hepatobiliary_system	1.07539057
32	MP0001963_abnormal_hearing_physiology	1.04290012
33	MP0004510_myositis	1.03241561
34	MP0005395_other_phenotype	1.01872285
35	MP0008877_abnormal_DNA_methylation	1.01722237
36	MP0002822_catalepsy	0.98570176
37	MP0000026_abnormal_inner_ear	0.96649348
38	MP0004859_abnormal_synaptic_plasticity	0.93862313
39	MP0000681_abnormal_thyroid_gland	0.93574074
40	MP0003879_abnormal_hair_cell	0.93557911
41	MP0001765_abnormal_ion_homeostasis	0.92184277
42	MP0005310_abnormal_salivary_gland	0.88835137
43	MP0008004_abnormal_stomach_pH	0.85406394
44	MP0000049_abnormal_middle_ear	0.84787167
45	MP0005367_renal/urinary_system_phenotyp	0.79259369
46	MP0000516_abnormal_urinary_system	0.79259369
47	MP0002229_neurodegeneration	0.78971608
48	MP0003136_yellow_coat_color	0.76575293
49	MP0004085_abnormal_heartbeat	0.73645147
50	MP0005253_abnormal_eye_physiology	0.71836941
51	MP0001879_abnormal_lymphatic_vessel	0.71493780
52	MP0001905_abnormal_dopamine_level	0.71058498
53	MP0003936_abnormal_reproductive_system	0.69138676
54	MP0000955_abnormal_spinal_cord	0.68701667
55	MP0002067_abnormal_sensory_capabilities	0.67920075
56	MP0005551_abnormal_eye_electrophysiolog	0.67076246
57	MP0001984_abnormal_olfaction	0.65230263
58	MP0009115_abnormal_fat_cell	0.62760826
59	MP0005666_abnormal_adipose_tissue	0.62394361
60	MP0008995_early_reproductive_senescence	0.60669455
61	MP0005647_abnormal_sex_gland	0.59820748
62	MP0005451_abnormal_body_composition	0.59461294
63	MP0008569_lethality_at_weaning	0.58966692
64	MP0003315_abnormal_perineum_morphology	0.57885644
65	MP0002160_abnormal_reproductive_system	0.57440485
66	MP0002557_abnormal_social/conspecific_i	0.57250393
67	MP0002733_abnormal_thermal_nociception	0.56132782
68	MP0005167_abnormal_blood-brain_barrier	0.54016019
69	MP0003119_abnormal_digestive_system	0.53550709
70	MP0003077_abnormal_cell_cycle	0.51702166
71	MP0010368_abnormal_lymphatic_system	0.50425340
72	MP0005375_adipose_tissue_phenotype	0.50005386
73	MP0009697_abnormal_copulation	0.49996409
74	MP0010386_abnormal_urinary_bladder	0.49332217
75	MP0005636_abnormal_mineral_homeostasis	0.47984171
76	MP0004233_abnormal_muscle_weight	0.47118111
77	MP0000470_abnormal_stomach_morphology	0.46262423
78	MP0003699_abnormal_female_reproductive	0.46197848
79	MP0002653_abnormal_ependyma_morphology	0.46182031
80	MP0000566_synostosis	0.44846430
81	MP0002572_abnormal_emotion/affect_behav	0.44449738
82	MP0002272_abnormal_nervous_system	0.43250584
83	MP0004036_abnormal_muscle_relaxation	0.41743539
84	MP0005535_abnormal_body_temperature	0.41357167
85	MP0005408_hypopigmentation	0.41037266
86	MP0001501_abnormal_sleep_pattern	0.40964567
87	MP0005083_abnormal_biliary_tract	0.40023695
88	MP0009745_abnormal_behavioral_response	0.39564675
89	MP0003880_abnormal_central_pattern	0.39311817
90	MP0005391_vision/eye_phenotype	0.38272647
91	MP0001970_abnormal_pain_threshold	0.37113562
92	MP0004484_altered_response_of	0.36901932
93	MP0001666_abnormal_nutrient_absorption	0.35869289
94	MP0005499_abnormal_olfactory_system	0.35699927
95	MP0005394_taste/olfaction_phenotype	0.35699927
96	MP0002734_abnormal_mechanical_nocicepti	0.35392273
97	MP0003631_nervous_system_phenotype	0.35336539
98	MP0000467_abnormal_esophagus_morphology	0.34951376
99	MP0000003_abnormal_adipose_tissue	0.33009047
100	MP0005623_abnormal_meninges_morphology	0.31993786

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.10211682
2	Absent/shortened dynein arms (HP:0200106)	6.36786429
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.36786429
4	Resting tremor (HP:0002322)	5.28309526
5	Abnormal ciliary motility (HP:0012262)	5.12474506
6	Abnormal respiratory motile cilium physiology (HP:0012261)	5.04742845
7	Attenuation of retinal blood vessels (HP:0007843)	4.98613363
8	Bony spicule pigmentary retinopathy (HP:0007737)	4.95620622
9	Abnormal respiratory epithelium morphology (HP:0012253)	4.70967172
10	Abnormal respiratory motile cilium morphology (HP:0005938)	4.70967172
11	Infertility (HP:0000789)	4.62493068
12	Asymmetric septal hypertrophy (HP:0001670)	4.60690179
13	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.36813402
14	Tubulointerstitial nephritis (HP:0001970)	4.33644708
15	Nasal polyposis (HP:0100582)	4.32061857
16	Abnormality of macular pigmentation (HP:0008002)	4.15489138
17	Abnormal rod and cone electroretinograms (HP:0008323)	4.10253581
18	Bell-shaped thorax (HP:0001591)	4.09720515
19	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.99888670
20	Chronic hepatic failure (HP:0100626)	3.84137047
21	Male infertility (HP:0003251)	3.78678531
22	Hyperkalemia (HP:0002153)	3.75949928
23	Hypoplastic ischia (HP:0003175)	3.71060889
24	Potter facies (HP:0002009)	3.59469366
25	Facial shape deformation (HP:0011334)	3.59469366
26	Enlarged epiphyses (HP:0010580)	3.58601725
27	Abnormality of the nasal mucosa (HP:0000433)	3.50192260
28	Azoospermia (HP:0000027)	3.44763475
29	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.37550717
30	Abnormality of the ischium (HP:0003174)	3.30756144
31	Abnormal spermatogenesis (HP:0008669)	3.26495394
32	Impulsivity (HP:0100710)	3.24281544
33	Postural instability (HP:0002172)	3.22779090
34	Cone-rod dystrophy (HP:0000548)	3.06991007
35	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.94962393
36	Rhinitis (HP:0012384)	2.82912051
37	Unilateral renal agenesis (HP:0000122)	2.82605694
38	Sensory axonal neuropathy (HP:0003390)	2.80693332
39	Renal dysplasia (HP:0000110)	2.76982529
40	Progressive sensorineural hearing impairment (HP:0000408)	2.75690263
41	Abnormal urine output (HP:0012590)	2.71370313
42	Osteomalacia (HP:0002749)	2.71098946
43	Hypoplasia of the thymus (HP:0000778)	2.57826943
44	Congenital malformation of the right heart (HP:0011723)	2.54860272
45	Double outlet right ventricle (HP:0001719)	2.54860272
46	Abnormality of the aortic arch (HP:0012303)	2.54187999
47	Nephronophthisis (HP:0000090)	2.49124520
48	Stage 5 chronic kidney disease (HP:0003774)	2.48461550
49	Abnormality of dental color (HP:0011073)	2.42660316
50	Abnormality of renal excretion (HP:0011036)	2.37812330
51	Generalized aminoaciduria (HP:0002909)	2.37811410
52	Abnormal drinking behavior (HP:0030082)	2.36567098
53	Polydipsia (HP:0001959)	2.36567098
54	Abnormality of the costochondral junction (HP:0000919)	2.30414995
55	Hypoalphalipoproteinemia (HP:0003233)	2.27987794
56	Progressive cerebellar ataxia (HP:0002073)	2.27077450
57	Truncal obesity (HP:0001956)	2.24794807
58	Abnormality of potassium homeostasis (HP:0011042)	2.23416871
59	Bronchiectasis (HP:0002110)	2.22031133
60	Amelogenesis imperfecta (HP:0000705)	2.19883001
61	Polyuria (HP:0000103)	2.19717156
62	Flattened epiphyses (HP:0003071)	2.14812037
63	Tubulointerstitial abnormality (HP:0001969)	2.14225198
64	Neonatal short-limb short stature (HP:0008921)	2.07848739
65	Optic nerve hypoplasia (HP:0000609)	2.07835644
66	Abnormality of the renal medulla (HP:0100957)	2.03861071
67	Chronic bronchitis (HP:0004469)	2.02653474
68	Absent epiphyses (HP:0010577)	2.02208407
69	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.02208407
70	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.01002345
71	Widely patent fontanelles and sutures (HP:0004492)	2.00493225
72	Cerebellar dysplasia (HP:0007033)	1.98007049
73	Portal hypertension (HP:0001409)	1.92761381
74	Atelectasis (HP:0100750)	1.91865118
75	Hyponatremia (HP:0002902)	1.89820723
76	Epiphyseal dysplasia (HP:0002656)	1.89603101
77	Recurrent corneal erosions (HP:0000495)	1.89525998
78	Ventricular tachycardia (HP:0004756)	1.87606640
79	Type II lissencephaly (HP:0007260)	1.87261798
80	Insulin-resistant diabetes mellitus (HP:0000831)	1.87070318
81	Short ribs (HP:0000773)	1.86660920
82	Abnormality of the pubic bones (HP:0003172)	1.86606018
83	Spastic paraparesis (HP:0002313)	1.85118541
84	Occipital encephalocele (HP:0002085)	1.84279586
85	Hypophosphatemic rickets (HP:0004912)	1.83438535
86	Increased purine levels (HP:0004368)	1.83008550
87	Hyperuricemia (HP:0002149)	1.83008550
88	Abnormality of the parathyroid morphology (HP:0011766)	1.81960535
89	Peripheral hypomyelination (HP:0007182)	1.80178404
90	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.80158474
91	Congenital sensorineural hearing impairment (HP:0008527)	1.79820808
92	Abnormality of the hepatic vasculature (HP:0006707)	1.78059906
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76425637
94	Tetany (HP:0001281)	1.73546173
95	Glycosuria (HP:0003076)	1.72753362
96	Abnormality of urine glucose concentration (HP:0011016)	1.72753362
97	Hyperthyroidism (HP:0000836)	1.72495633
98	Renovascular hypertension (HP:0100817)	1.71874025
99	Retinal dysplasia (HP:0007973)	1.71861411
100	Amblyopia (HP:0000646)	1.71476894

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.08340632
2	TESK1	5.82862669
3	DDR2	4.63244640
4	PNCK	4.23140119
5	STK38	3.48599439
6	MAP4K2	3.33803854
7	INSRR	3.00128765
8	PINK1	2.91721352
9	PLK2	2.74487205
10	BRD4	2.52572666
11	CAMK1G	2.38498507
12	MAPK15	2.32384316
13	PRKD3	2.29679194
14	STK38L	2.18413446
15	WNK1	1.80432320
16	MST1R	1.76764835
17	PDPK1	1.60129353
18	PDK1	1.43107795
19	PIK3CG	1.36543514
20	LATS2	1.23853596
21	CDK7	1.19625800
22	MAP3K9	1.19210919
23	PTK2B	1.19068306
24	DYRK1B	1.14438161
25	MARK3	1.06116092
26	CDK12	1.02755722
27	NEK6	1.02567308
28	LATS1	0.99625794
29	KSR2	0.92612659
30	MAP3K11	0.91894230
31	BMPR1B	0.88680200
32	BRAF	0.85344931
33	TLK1	0.77990705
34	RPS6KA2	0.75577614
35	PRKG2	0.75284716
36	CDK3	0.74276594
37	ZAK	0.72748409
38	STK39	0.69759111
39	PRKG1	0.69195096
40	RPS6KA1	0.68403458
41	PRKAA2	0.61336736
42	AKT3	0.59537160
43	CAMK1	0.57671870
44	MAP3K2	0.56327461
45	UHMK1	0.55177179
46	WNK4	0.54734192
47	SGK494	0.54046547
48	SGK223	0.54046547
49	CAMK1D	0.51561141
50	ACVR1B	0.51047182
51	MAP2K2	0.50727730
52	MAP3K8	0.50569153
53	ROCK1	0.49778194
54	TYRO3	0.48985896
55	NEK2	0.48046367
56	MAP3K1	0.46536502
57	ARAF	0.45067606
58	RPS6KC1	0.41550591
59	RPS6KL1	0.41550591
60	RPS6KA5	0.41481918
61	RPS6KA6	0.41222320
62	MTOR	0.40845986
63	GSK3B	0.39657770
64	MAPK1	0.39129452
65	SIK2	0.38924247
66	CDK4	0.38864329
67	CDK2	0.36819595
68	CDK1	0.35751790
69	MUSK	0.32796122
70	OXSR1	0.32178153
71	CHEK1	0.31318268
72	MYLK	0.30602201
73	DYRK2	0.30496884
74	PRKCG	0.29932742
75	MET	0.29718890
76	SGK1	0.27988639
77	TIE1	0.27429503
78	NTRK3	0.25613868
79	CAMK4	0.24496110
80	MAPK8	0.23980392
81	DYRK3	0.23872685
82	MAP3K13	0.22955364
83	TNIK	0.21680562
84	PKN1	0.21519911
85	MAP3K4	0.20959510
86	CDK19	0.20825651
87	MAP2K7	0.20087268
88	PRKCZ	0.19722187
89	MAPK14	0.17808278
90	PRKCB	0.16577468
91	FRK	0.14795807
92	AKT1	0.14591981
93	PRKCQ	0.14236447
94	MAPK10	0.14139725
95	OBSCN	0.11996011
96	BRSK1	0.11922283
97	MARK2	0.10719901
98	PASK	0.10391722
99	PRKACB	0.10154265
100	FGFR2	0.08935769

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.14079969
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.80210959
3	Olfactory transduction_Homo sapiens_hsa04740	3.89080449
4	Butanoate metabolism_Homo sapiens_hsa00650	3.00580668
5	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.15469153
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.99741865
7	Allograft rejection_Homo sapiens_hsa05330	1.81858360
8	Type I diabetes mellitus_Homo sapiens_hsa04940	1.79058669
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.76068243
10	Antigen processing and presentation_Homo sapiens_hsa04612	1.73160696
11	Graft-versus-host disease_Homo sapiens_hsa05332	1.67497238
12	RNA transport_Homo sapiens_hsa03013	1.62328521
13	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.58712266
14	Taste transduction_Homo sapiens_hsa04742	1.56582333
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.48786210
16	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.46246639
17	Fatty acid degradation_Homo sapiens_hsa00071	1.44278916
18	Phenylalanine metabolism_Homo sapiens_hsa00360	1.40805133
19	Type II diabetes mellitus_Homo sapiens_hsa04930	1.36602484
20	Fatty acid metabolism_Homo sapiens_hsa01212	1.27308407
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.24528535
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.24191834
23	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.22822911
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.21968788
25	Viral myocarditis_Homo sapiens_hsa05416	1.21713968
26	Endocytosis_Homo sapiens_hsa04144	1.12713271
27	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.10250724
28	Oocyte meiosis_Homo sapiens_hsa04114	1.09813748
29	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.08226124
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.07958697
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.01993970
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00883077
33	Protein digestion and absorption_Homo sapiens_hsa04974	0.98155086
34	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98094237
35	Gap junction_Homo sapiens_hsa04540	0.95367226
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.92791991
37	Phototransduction_Homo sapiens_hsa04744	0.88039502
38	PPAR signaling pathway_Homo sapiens_hsa03320	0.85803442
39	Salivary secretion_Homo sapiens_hsa04970	0.85469237
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83085880
41	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.81171768
42	Calcium signaling pathway_Homo sapiens_hsa04020	0.77133037
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76408198
44	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.75226820
45	Influenza A_Homo sapiens_hsa05164	0.74496296
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.74365231
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.72299555
48	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.70740532
49	Estrogen signaling pathway_Homo sapiens_hsa04915	0.67534598
50	cAMP signaling pathway_Homo sapiens_hsa04024	0.66907230
51	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.63367248
52	Retinol metabolism_Homo sapiens_hsa00830	0.63107715
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61390750
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61112762
55	Nicotine addiction_Homo sapiens_hsa05033	0.59708050
56	Purine metabolism_Homo sapiens_hsa00230	0.59283507
57	Morphine addiction_Homo sapiens_hsa05032	0.59116645
58	Caffeine metabolism_Homo sapiens_hsa00232	0.58844904
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.57088812
60	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.57077456
61	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56992255
62	Basal transcription factors_Homo sapiens_hsa03022	0.56312699
63	Phagosome_Homo sapiens_hsa04145	0.54559446
64	ABC transporters_Homo sapiens_hsa02010	0.54491041
65	Circadian entrainment_Homo sapiens_hsa04713	0.52924604
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50883945
67	Renin secretion_Homo sapiens_hsa04924	0.48091117
68	MAPK signaling pathway_Homo sapiens_hsa04010	0.47116834
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46418810
70	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46012154
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45444062
72	Gastric acid secretion_Homo sapiens_hsa04971	0.44296942
73	Propanoate metabolism_Homo sapiens_hsa00640	0.40469768
74	Renin-angiotensin system_Homo sapiens_hsa04614	0.40169698
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.39758883
76	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38051587
77	Insulin secretion_Homo sapiens_hsa04911	0.37686547
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37403314
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37232458
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.36249679
81	Tight junction_Homo sapiens_hsa04530	0.36107326
82	Alcoholism_Homo sapiens_hsa05034	0.34635517
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34481810
84	VEGF signaling pathway_Homo sapiens_hsa04370	0.33217527
85	Acute myeloid leukemia_Homo sapiens_hsa05221	0.31908328
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31427948
87	Bile secretion_Homo sapiens_hsa04976	0.28834880
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.28046708
89	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26650751
90	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25747005
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25625493
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.23939759
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.23880675
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.20980915
95	Legionellosis_Homo sapiens_hsa05134	0.20288049
96	Circadian rhythm_Homo sapiens_hsa04710	0.20259519
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.19215555
98	Herpes simplex infection_Homo sapiens_hsa05168	0.17028240
99	ECM-receptor interaction_Homo sapiens_hsa04512	0.17020827
100	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.16887663

OR7E101P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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