ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.59720787
2	DNA packaging (GO:0006323)	9.36041815
3	sperm capacitation (GO:0048240)	8.76433355
4	spermatid nucleus differentiation (GO:0007289)	8.46424558
5	single strand break repair (GO:0000012)	8.42966785
6	spermatid development (GO:0007286)	8.36410154
7	response to pheromone (GO:0019236)	8.18501010
8	microtubule depolymerization (GO:0007019)	8.02891198
9	plasma membrane fusion (GO:0045026)	7.85691517
10	sperm-egg recognition (GO:0035036)	7.56484825
11	protein targeting to Golgi (GO:0000042)	7.48471526
12	binding of sperm to zona pellucida (GO:0007339)	7.30365987
13	protein polyglutamylation (GO:0018095)	7.28546155
14	establishment of protein localization to Golgi (GO:0072600)	7.16985333
15	rRNA methylation (GO:0031167)	7.03398222
16	sexual reproduction (GO:0019953)	7.01674763
17	microtubule polymerization or depolymerization (GO:0031109)	6.96366978
18	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.94908528
19	multicellular organism reproduction (GO:0032504)	6.87729562
20	axonemal dynein complex assembly (GO:0070286)	6.83685390
21	reproduction (GO:0000003)	6.67502785
22	spermatogenesis (GO:0007283)	6.40877824
23	male gamete generation (GO:0048232)	6.38879877
24	calcium ion-dependent exocytosis (GO:0017156)	6.37730078
25	negative regulation of inclusion body assembly (GO:0090084)	6.35427417
26	cell-cell recognition (GO:0009988)	6.21904151
27	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.18040822
28	centriole replication (GO:0007099)	6.14372775
29	rRNA modification (GO:0000154)	5.90805720
30	gamete generation (GO:0007276)	5.88191812
31	motile cilium assembly (GO:0044458)	5.87733697
32	phosphatidylethanolamine metabolic process (GO:0046337)	5.70325334
33	centriole assembly (GO:0098534)	5.48776503
34	protein localization to Golgi apparatus (GO:0034067)	5.40787323
35	microtubule severing (GO:0051013)	5.33107807
36	regulation of cilium movement (GO:0003352)	5.22130492
37	single fertilization (GO:0007338)	5.21773983
38	regulation of centriole replication (GO:0046599)	5.19580919
39	seminiferous tubule development (GO:0072520)	5.17201482
40	cilium or flagellum-dependent cell motility (GO:0001539)	5.13839621
41	positive regulation of Rab GTPase activity (GO:0032851)	4.92569495
42	regulation of Rab GTPase activity (GO:0032313)	4.92569495
43	germ cell development (GO:0007281)	4.89314425
44	cellular ketone body metabolic process (GO:0046950)	4.88524481
45	epithelial cilium movement (GO:0003351)	4.83798918
46	chromatin silencing (GO:0006342)	4.79015873
47	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.74423633
48	multicellular organismal reproductive process (GO:0048609)	4.69976289
49	RNA destabilization (GO:0050779)	4.68914056
50	fertilization (GO:0009566)	4.65550001
51	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.61325522
52	regulation of inclusion body assembly (GO:0090083)	4.49452976
53	nucleus organization (GO:0006997)	4.38514157
54	ketone body metabolic process (GO:1902224)	4.30333177
55	cell wall macromolecule catabolic process (GO:0016998)	4.17708546
56	cilium movement (GO:0003341)	4.15094200
57	cell wall macromolecule metabolic process (GO:0044036)	4.07853219
58	regulation of transcription involved in cell fate commitment (GO:0060850)	4.02127318
59	male meiosis I (GO:0007141)	3.94293945
60	glomerular visceral epithelial cell development (GO:0072015)	3.91559105
61	male meiosis (GO:0007140)	3.88787956
62	nucleosome disassembly (GO:0006337)	3.83848504
63	protein-DNA complex disassembly (GO:0032986)	3.83848504
64	piRNA metabolic process (GO:0034587)	3.82225389
65	glycerol ether metabolic process (GO:0006662)	3.74383562
66	glomerular epithelial cell development (GO:0072310)	3.72357860
67	microtubule nucleation (GO:0007020)	3.67259835
68	coenzyme catabolic process (GO:0009109)	3.61010710
69	multicellular organismal movement (GO:0050879)	3.54529375
70	musculoskeletal movement (GO:0050881)	3.54529375
71	histone H3-K9 demethylation (GO:0033169)	3.50397678
72	organic cation transport (GO:0015695)	3.50051137
73	ether metabolic process (GO:0018904)	3.45186079
74	polyamine biosynthetic process (GO:0006596)	3.39799240
75	regulation of microtubule-based movement (GO:0060632)	3.36851090
76	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.30294924
77	negative regulation of gene expression, epigenetic (GO:0045814)	3.28197006
78	DNA methylation involved in gamete generation (GO:0043046)	3.27951383
79	negative regulation of Rho protein signal transduction (GO:0035024)	3.26498224
80	response to acidic pH (GO:0010447)	3.16099124
81	cerebral cortex neuron differentiation (GO:0021895)	3.13314919
82	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.12529033
83	DNA conformation change (GO:0071103)	3.07732271
84	multicellular organismal development (GO:0007275)	3.05211404
85	regulation of interleukin-13 production (GO:0032656)	3.03677486
86	protein depolymerization (GO:0051261)	3.02224243
87	nuclear pore complex assembly (GO:0051292)	3.02051553
88	cell recognition (GO:0008037)	3.01968841
89	synaptonemal complex assembly (GO:0007130)	3.00945393
90	chromosome organization involved in meiosis (GO:0070192)	2.99800925
91	histone exchange (GO:0043486)	2.99683570
92	homeostasis of number of cells within a tissue (GO:0048873)	2.98500592
93	receptor recycling (GO:0001881)	2.97301597
94	meiosis I (GO:0007127)	2.97065513
95	ventricular system development (GO:0021591)	2.96552119
96	cellular response to pH (GO:0071467)	2.96306210
97	synapsis (GO:0007129)	2.95835082
98	sperm motility (GO:0030317)	12.1310698
99	acrosome reaction (GO:0007340)	11.9056300
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.3161176

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.70052982
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.36079046
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.55026389
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53026804
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.53026804
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.32471760
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30862819
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.30347755
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.30347755
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.26573517
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.21434695
12	FUS_26573619_Chip-Seq_HEK293_Human	2.19588458
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.16033804
14	ERA_21632823_ChIP-Seq_H3396_Human	2.11035869
15	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.95456754
16	RAC3_21632823_ChIP-Seq_H3396_Human	1.94247694
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90587268
18	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.88891177
19	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.85746003
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.81165038
21	NANOG_20526341_ChIP-Seq_ESCs_Human	1.79659859
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.78009061
23	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71407408
24	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.70596484
25	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.69625599
26	CTCF_27219007_Chip-Seq_Bcells_Human	1.67293440
27	MYC_19829295_ChIP-Seq_ESCs_Human	1.66749286
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65278672
29	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.59842182
30	SMC4_20622854_ChIP-Seq_HELA_Human	1.59497787
31	BCL6_27268052_Chip-Seq_Bcells_Human	1.58145527
32	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.55320306
33	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.55238391
34	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.52244063
35	OCT4_20526341_ChIP-Seq_ESCs_Human	1.50728760
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50153153
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.49693449
38	E2F1_20622854_ChIP-Seq_HELA_Human	1.49592261
39	P68_20966046_ChIP-Seq_HELA_Human	1.47866528
40	CTCF_20526341_ChIP-Seq_ESCs_Human	1.47235907
41	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.47080142
42	PHF8_20622854_ChIP-Seq_HELA_Human	1.46266098
43	AR_25329375_ChIP-Seq_VCAP_Human	1.45635191
44	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.45109018
45	BCOR_27268052_Chip-Seq_Bcells_Human	1.44267939
46	RBPJ_21746931_ChIP-Seq_IB4_Human	1.44059866
47	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.43801996
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43422700
49	TP63_22573176_ChIP-Seq_HFKS_Human	1.41756379
50	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.41721303
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39305131
52	ETV1_20927104_ChIP-Seq_GIST48_Human	1.38353734
53	ERG_20517297_ChIP-Seq_VCAP_Human	1.37266403
54	P300_19829295_ChIP-Seq_ESCs_Human	1.34514363
55	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.32932047
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32732836
57	TBL1_22424771_ChIP-Seq_293T_Human	1.31411310
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30931947
59	ZNF274_21170338_ChIP-Seq_K562_Hela	1.30768845
60	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.28624916
61	TP53_18474530_ChIP-ChIP_U2OS_Human	1.28541361
62	CEBPB_22108803_ChIP-Seq_LS180_Human	1.28346688
63	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28338836
64	NFYB_21822215_ChIP-Seq_K562_Human	1.28018251
65	P300_27268052_Chip-Seq_Bcells_Human	1.26678892
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26493130
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26195063
68	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.25423314
69	PHF8_20622853_ChIP-Seq_HELA_Human	1.23117235
70	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.22030935
71	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.21898348
72	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.20407303
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19636863
74	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.19611631
75	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.15883182
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14813508
77	LXR_22292898_ChIP-Seq_THP-1_Human	1.13648338
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13550771
79	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.12774224
80	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.12724263
81	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.12637367
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11920841
83	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09561511
84	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.09522952
85	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.07954517
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07925386
87	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.07238456
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07224248
89	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.06336919
90	NFYA_21822215_ChIP-Seq_K562_Human	1.06323831
91	TAF15_26573619_Chip-Seq_HEK293_Human	1.06089562
92	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05879275
93	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04455124
94	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04455124
95	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04436465
96	SA1_27219007_Chip-Seq_Bcells_Human	1.03482877
97	STAT3_23295773_ChIP-Seq_U87_Human	1.03477575
98	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02798584
99	AR_21572438_ChIP-Seq_LNCaP_Human	1.02374859
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01977962

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.14141298
2	MP0005377_hearing/vestibular/ear_phenot	5.14141298
3	MP0003698_abnormal_male_reproductive	4.70723607
4	MP0005670_abnormal_white_adipose	4.28973296
5	MP0001929_abnormal_gametogenesis	4.20576243
6	MP0001348_abnormal_lacrimal_gland	3.78598234
7	MP0002161_abnormal_fertility/fecundity	2.60995455
8	MP0000678_abnormal_parathyroid_gland	2.34792610
9	MP0003718_maternal_effect	2.15257604
10	MP0002210_abnormal_sex_determination	2.14271874
11	MP0002132_abnormal_respiratory_system	2.11144170
12	MP0003646_muscle_fatigue	2.06822284
13	MP0005379_endocrine/exocrine_gland_phen	2.00549940
14	MP0005410_abnormal_fertilization	12.2939110
15	MP0003011_delayed_dark_adaptation	1.95285870
16	MP0001485_abnormal_pinna_reflex	1.79646664
17	MP0008877_abnormal_DNA_methylation	1.75909783
18	MP0001145_abnormal_male_reproductive	1.73158251
19	MP0005423_abnormal_somatic_nervous	1.62451475
20	MP0000653_abnormal_sex_gland	1.60555178
21	MP0001486_abnormal_startle_reflex	1.56141705
22	MP0002282_abnormal_trachea_morphology	1.48325611
23	MP0002249_abnormal_larynx_morphology	1.39129548
24	MP0004742_abnormal_vestibular_system	1.38198447
25	MP0005451_abnormal_body_composition	1.33644323
26	MP0003879_abnormal_hair_cell	1.33454867
27	MP0005310_abnormal_salivary_gland	1.33122241
28	MP0009053_abnormal_anal_canal	1.20588438
29	MP0002234_abnormal_pharynx_morphology	1.18652808
30	MP0002735_abnormal_chemical_nociception	1.15244725
31	MP0001963_abnormal_hearing_physiology	1.14856211
32	MP0002138_abnormal_hepatobiliary_system	1.08715514
33	MP0004859_abnormal_synaptic_plasticity	1.06055130
34	MP0001765_abnormal_ion_homeostasis	1.05316171
35	MP0002127_abnormal_cardiovascular_syste	1.02884633
36	MP0001968_abnormal_touch/_nociception	1.02406237
37	MP0004510_myositis	0.99710897
38	MP0005248_abnormal_Harderian_gland	0.99047748
39	MP0005395_other_phenotype	0.96803425
40	MP0000534_abnormal_ureter_morphology	0.96529158
41	MP0000026_abnormal_inner_ear	0.96421815
42	MP0001984_abnormal_olfaction	0.89046587
43	MP0002822_catalepsy	0.87078773
44	MP0009115_abnormal_fat_cell	0.82305505
45	MP0005551_abnormal_eye_electrophysiolog	0.82261558
46	MP0005253_abnormal_eye_physiology	0.82107810
47	MP0002229_neurodegeneration	0.79793539
48	MP0000955_abnormal_spinal_cord	0.77568711
49	MP0005666_abnormal_adipose_tissue	0.75074685
50	MP0000681_abnormal_thyroid_gland	0.75044975
51	MP0000049_abnormal_middle_ear	0.74395234
52	MP0008995_early_reproductive_senescence	0.73978299
53	MP0002067_abnormal_sensory_capabilities	0.72449621
54	MP0005167_abnormal_blood-brain_barrier	0.70856391
55	MP0004085_abnormal_heartbeat	0.68461435
56	MP0002733_abnormal_thermal_nociception	0.66619702
57	MP0002557_abnormal_social/conspecific_i	0.64643846
58	MP0009697_abnormal_copulation	0.63324766
59	MP0004233_abnormal_muscle_weight	0.61069106
60	MP0001879_abnormal_lymphatic_vessel	0.60086751
61	MP0002572_abnormal_emotion/affect_behav	0.57147045
62	MP0001905_abnormal_dopamine_level	0.55950273
63	MP0008569_lethality_at_weaning	0.54498755
64	MP0003077_abnormal_cell_cycle	0.54409881
65	MP0004036_abnormal_muscle_relaxation	0.54061246
66	MP0005083_abnormal_biliary_tract	0.53354959
67	MP0005636_abnormal_mineral_homeostasis	0.53257132
68	MP0005375_adipose_tissue_phenotype	0.52039637
69	MP0003699_abnormal_female_reproductive	0.51323595
70	MP0009745_abnormal_behavioral_response	0.50634322
71	MP0005535_abnormal_body_temperature	0.49391979
72	MP0008789_abnormal_olfactory_epithelium	0.49378980
73	MP0005367_renal/urinary_system_phenotyp	0.48576069
74	MP0000516_abnormal_urinary_system	0.48576069
75	MP0002653_abnormal_ependyma_morphology	0.48180389
76	MP0006292_abnormal_olfactory_placode	0.47717005
77	MP0002272_abnormal_nervous_system	0.47713495
78	MP0001666_abnormal_nutrient_absorption	0.47603421
79	MP0001970_abnormal_pain_threshold	0.47204732
80	MP0005394_taste/olfaction_phenotype	0.46206474
81	MP0005499_abnormal_olfactory_system	0.46206474
82	MP0002160_abnormal_reproductive_system	0.45762248
83	MP0008004_abnormal_stomach_pH	0.44390719
84	MP0000230_abnormal_systemic_arterial	0.42295995
85	MP0005391_vision/eye_phenotype	0.41261907
86	MP0005623_abnormal_meninges_morphology	0.39298578
87	MP0001501_abnormal_sleep_pattern	0.38812584
88	MP0005084_abnormal_gallbladder_morpholo	0.38778995
89	MP0003936_abnormal_reproductive_system	0.38367984
90	MP0003880_abnormal_central_pattern	0.37661425
91	MP0004484_altered_response_of	0.37616600
92	MP0004782_abnormal_surfactant_physiolog	0.37516279
93	MP0001119_abnormal_female_reproductive	0.37343575
94	MP0004084_abnormal_cardiac_muscle	0.37253495
95	MP0002734_abnormal_mechanical_nocicepti	0.36511918
96	MP0003137_abnormal_impulse_conducting	0.36238594
97	MP0005647_abnormal_sex_gland	0.35732955
98	MP0010368_abnormal_lymphatic_system	0.35259788
99	MP0000470_abnormal_stomach_morphology	0.34645059
100	MP0003635_abnormal_synaptic_transmissio	0.34338871

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.72156523
2	Absent/shortened dynein arms (HP:0200106)	6.95315703
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.95315703
4	Tubulointerstitial nephritis (HP:0001970)	5.76113417
5	Abnormal respiratory motile cilium physiology (HP:0012261)	5.40557907
6	Abnormal ciliary motility (HP:0012262)	5.39232984
7	Asymmetric septal hypertrophy (HP:0001670)	5.27909644
8	Chronic hepatic failure (HP:0100626)	5.09510898
9	Abnormal respiratory epithelium morphology (HP:0012253)	5.00199999
10	Abnormal respiratory motile cilium morphology (HP:0005938)	5.00199999
11	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.97433106
12	Resting tremor (HP:0002322)	4.88678421
13	Nasal polyposis (HP:0100582)	4.80789076
14	Attenuation of retinal blood vessels (HP:0007843)	4.65616153
15	Bony spicule pigmentary retinopathy (HP:0007737)	4.65494186
16	Infertility (HP:0000789)	4.54816001
17	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.15693662
18	Male infertility (HP:0003251)	4.08174842
19	Hyperkalemia (HP:0002153)	4.05188285
20	Abnormality of macular pigmentation (HP:0008002)	4.03836344
21	Cone-rod dystrophy (HP:0000548)	4.02590498
22	Abnormality of the nasal mucosa (HP:0000433)	3.90923075
23	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.61457364
24	Abnormal spermatogenesis (HP:0008669)	3.52510680
25	Facial shape deformation (HP:0011334)	3.48720821
26	Potter facies (HP:0002009)	3.48720821
27	Abnormal rod and cone electroretinograms (HP:0008323)	3.48555084
28	Bell-shaped thorax (HP:0001591)	3.46426669
29	Azoospermia (HP:0000027)	3.44364196
30	Impulsivity (HP:0100710)	3.34295569
31	Rhinitis (HP:0012384)	3.21424880
32	Postural instability (HP:0002172)	3.21293194
33	Progressive sensorineural hearing impairment (HP:0000408)	3.19557957
34	Hypoplasia of the thymus (HP:0000778)	3.11558303
35	Nephronophthisis (HP:0000090)	3.03414155
36	Abnormality of dental color (HP:0011073)	3.00099917
37	Hypoalphalipoproteinemia (HP:0003233)	2.97311465
38	Stage 5 chronic kidney disease (HP:0003774)	2.94335998
39	Enlarged epiphyses (HP:0010580)	2.89641570
40	Hypoplastic ischia (HP:0003175)	2.89150822
41	Progressive cerebellar ataxia (HP:0002073)	2.87526844
42	Amelogenesis imperfecta (HP:0000705)	2.81112246
43	Menstrual irregularities (HP:0000858)	2.79776141
44	Tubulointerstitial abnormality (HP:0001969)	2.76417237
45	Truncal obesity (HP:0001956)	2.68767281
46	Abnormal urine output (HP:0012590)	2.68023848
47	Chronic bronchitis (HP:0004469)	2.59800734
48	Abnormality of the ischium (HP:0003174)	2.57695465
49	Insulin-resistant diabetes mellitus (HP:0000831)	2.50360308
50	Abnormality of the renal medulla (HP:0100957)	2.50160520
51	Renovascular hypertension (HP:0100817)	2.50022492
52	Bronchiectasis (HP:0002110)	2.45912634
53	Polydipsia (HP:0001959)	2.44169400
54	Abnormal drinking behavior (HP:0030082)	2.44169400
55	Portal hypertension (HP:0001409)	2.43519989
56	Generalized aminoaciduria (HP:0002909)	2.41704655
57	Unilateral renal agenesis (HP:0000122)	2.36911568
58	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.33894157
59	Renal dysplasia (HP:0000110)	2.31116909
60	Abnormality of the aortic arch (HP:0012303)	2.30214633
61	Abnormality of renal excretion (HP:0011036)	2.30180838
62	Abnormality of potassium homeostasis (HP:0011042)	2.26702042
63	Osteomalacia (HP:0002749)	2.26232539
64	Abnormality of the hepatic vasculature (HP:0006707)	2.24405665
65	Abnormality of the costochondral junction (HP:0000919)	2.23415364
66	Polyuria (HP:0000103)	2.19336297
67	Congenital malformation of the right heart (HP:0011723)	2.18656498
68	Double outlet right ventricle (HP:0001719)	2.18656498
69	Flattened epiphyses (HP:0003071)	2.15932036
70	Hyperuricemia (HP:0002149)	2.15639177
71	Increased purine levels (HP:0004368)	2.15639177
72	Focal segmental glomerulosclerosis (HP:0000097)	2.11936568
73	Intellectual disability, moderate (HP:0002342)	2.11348259
74	Hypophosphatemic rickets (HP:0004912)	2.03979594
75	Progressive hearing impairment (HP:0001730)	1.97718399
76	Optic nerve hypoplasia (HP:0000609)	1.91422400
77	Decreased central vision (HP:0007663)	1.90821551
78	Tubular atrophy (HP:0000092)	1.90484834
79	Ventricular tachycardia (HP:0004756)	1.89306946
80	Widely patent fontanelles and sutures (HP:0004492)	1.86725861
81	Occipital encephalocele (HP:0002085)	1.84429257
82	Hyponatremia (HP:0002902)	1.80074726
83	Atelectasis (HP:0100750)	1.76520101
84	Horizontal nystagmus (HP:0000666)	1.76018904
85	Sensory axonal neuropathy (HP:0003390)	1.75047272
86	Myokymia (HP:0002411)	1.74533120
87	Recurrent corneal erosions (HP:0000495)	1.74339759
88	Photophobia (HP:0000613)	1.72512289
89	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.72294824
90	Upper limb muscle weakness (HP:0003484)	1.69838389
91	Abnormality of the parathyroid morphology (HP:0011766)	1.69704546
92	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.68658251
93	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.68225668
94	Absent epiphyses (HP:0010577)	1.68225668
95	Glomerulosclerosis (HP:0000096)	1.67999461
96	Pendular nystagmus (HP:0012043)	1.67132118
97	Flat capital femoral epiphysis (HP:0003370)	1.65289601
98	Renal Fanconi syndrome (HP:0001994)	1.64100920
99	Recurrent pneumonia (HP:0006532)	1.61580355
100	Hypoalbuminemia (HP:0003073)	1.60692114

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	9.30548233
2	TESK1	5.09671220
3	INSRR	3.95586926
4	BRD4	3.58821170
5	PLK2	3.57460266
6	DDR2	3.56425995
7	MAP4K2	3.34353726
8	PNCK	3.25020975
9	STK38	3.06964328
10	CAMK1G	2.38496906
11	STK38L	2.30988494
12	PRKD3	2.18145756
13	MAPK15	2.05407220
14	PIK3CG	2.02435515
15	PDPK1	1.63302912
16	MST1R	1.62924728
17	WNK1	1.59617733
18	PDK1	1.58393239
19	NEK6	1.42513862
20	PTK2B	1.34157379
21	CDK12	1.27318501
22	PINK1	1.25319006
23	DYRK1B	1.24301257
24	MAP3K9	1.19652351
25	TYRO3	1.16683316
26	CDK7	1.11320933
27	KSR2	0.90573072
28	LATS2	0.87689015
29	AKT3	0.82691649
30	MAP3K11	0.78392652
31	CAMK1D	0.78141389
32	BRAF	0.78009571
33	PRKG2	0.71863290
34	SIK2	0.71796403
35	PRKG1	0.65227507
36	CDK3	0.64635119
37	TIE1	0.62154022
38	MAP2K2	0.59277842
39	PRKAA2	0.59197428
40	CAMK1	0.58336460
41	RPS6KA1	0.57309221
42	UHMK1	0.56597915
43	BMPR1B	0.54403149
44	SGK223	0.52929689
45	SGK494	0.52929689
46	RPS6KA2	0.51328397
47	LATS1	0.50585428
48	MAP3K2	0.46717079
49	MARK1	0.44329182
50	CDK1	0.43243014
51	ROCK1	0.43057742
52	GSK3B	0.42907199
53	BRSK1	0.42795705
54	CDK2	0.42447157
55	NEK2	0.42221086
56	MAP3K8	0.41831789
57	MAPK1	0.41242445
58	MARK3	0.38947316
59	WNK4	0.38392120
60	CHEK1	0.34610945
61	STK39	0.33761266
62	MUSK	0.32997906
63	MTOR	0.32849123
64	MAP3K1	0.32269723
65	MET	0.32079273
66	ARAF	0.31542051
67	SGK1	0.30674794
68	PRKCZ	0.30404140
69	CAMK4	0.29280421
70	PRKCG	0.28873785
71	BRSK2	0.28351316
72	MAPK8	0.26580334
73	OXSR1	0.26503325
74	MAP3K4	0.26303795
75	CDK19	0.25722070
76	DYRK3	0.24840438
77	CDK4	0.23711407
78	NTRK3	0.23667726
79	RPS6KL1	0.22784231
80	RPS6KC1	0.22784231
81	MAP2K7	0.22048483
82	MAPK14	0.21711107
83	RPS6KA6	0.21663073
84	PKN1	0.20221617
85	TLK1	0.19914131
86	PRKCB	0.19054241
87	BLK	0.18966948
88	AKT1	0.17124707
89	PLK1	0.16655341
90	MAPK10	0.16453849
91	SGK2	0.15732228
92	TESK2	0.14879496
93	PRKACB	0.13551393
94	MAPK11	0.13169972
95	ZAK	0.12988516
96	MARK2	0.12110125
97	FRK	0.08798359
98	AURKA	0.08532519
99	PRKACA	0.08249335
100	PRKAA1	0.07885605

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.77088339
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.90998556
3	Olfactory transduction_Homo sapiens_hsa04740	4.09204901
4	Butanoate metabolism_Homo sapiens_hsa00650	2.81231739
5	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.00616769
6	RNA transport_Homo sapiens_hsa03013	1.90440394
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.85229573
8	Taste transduction_Homo sapiens_hsa04742	1.79608738
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.78847630
10	Type I diabetes mellitus_Homo sapiens_hsa04940	1.71897334
11	Allograft rejection_Homo sapiens_hsa05330	1.66503883
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.62651519
13	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.59499742
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.59352698
15	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.57374363
16	Fatty acid degradation_Homo sapiens_hsa00071	1.54571395
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.52142127
18	Type II diabetes mellitus_Homo sapiens_hsa04930	1.48722135
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.41211822
20	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.39025845
21	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.34244069
22	Viral myocarditis_Homo sapiens_hsa05416	1.20247124
23	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.20238015
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.15099262
25	Oocyte meiosis_Homo sapiens_hsa04114	1.10019627
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08804753
27	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.04467498
28	Arginine biosynthesis_Homo sapiens_hsa00220	1.04271560
29	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03654792
30	Phototransduction_Homo sapiens_hsa04744	1.01895445
31	Endocytosis_Homo sapiens_hsa04144	0.98962730
32	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98122625
33	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.97221223
34	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91473968
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91238446
36	Fat digestion and absorption_Homo sapiens_hsa04975	0.91003716
37	Protein digestion and absorption_Homo sapiens_hsa04974	0.89434352
38	Nicotine addiction_Homo sapiens_hsa05033	0.88310746
39	PPAR signaling pathway_Homo sapiens_hsa03320	0.87993738
40	Salivary secretion_Homo sapiens_hsa04970	0.86969675
41	Calcium signaling pathway_Homo sapiens_hsa04020	0.86360664
42	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.86150122
43	ABC transporters_Homo sapiens_hsa02010	0.78955408
44	Influenza A_Homo sapiens_hsa05164	0.76140963
45	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.75191860
46	Tyrosine metabolism_Homo sapiens_hsa00350	0.74794054
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.74110022
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73710338
49	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.72957087
50	Morphine addiction_Homo sapiens_hsa05032	0.72919973
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.71207004
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.69172246
53	Retinol metabolism_Homo sapiens_hsa00830	0.67190443
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66612575
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.66283037
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.63643140
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63229894
58	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61343051
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60277576
60	Circadian entrainment_Homo sapiens_hsa04713	0.59952015
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.57209651
62	VEGF signaling pathway_Homo sapiens_hsa04370	0.56207579
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56120601
64	Basal transcription factors_Homo sapiens_hsa03022	0.54836496
65	Renin secretion_Homo sapiens_hsa04924	0.53829030
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51804450
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.50603662
68	Propanoate metabolism_Homo sapiens_hsa00640	0.50401380
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.50213358
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48058172
71	Gap junction_Homo sapiens_hsa04540	0.47788816
72	Purine metabolism_Homo sapiens_hsa00230	0.45087645
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44270343
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43626856
75	Insulin secretion_Homo sapiens_hsa04911	0.42683591
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.41581630
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41523232
78	Gastric acid secretion_Homo sapiens_hsa04971	0.38821762
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.37146026
80	Serotonergic synapse_Homo sapiens_hsa04726	0.36241181
81	Bile secretion_Homo sapiens_hsa04976	0.34879888
82	Acute myeloid leukemia_Homo sapiens_hsa05221	0.33906973
83	Huntingtons disease_Homo sapiens_hsa05016	0.31972116
84	Cholinergic synapse_Homo sapiens_hsa04725	0.31814914
85	Pancreatic secretion_Homo sapiens_hsa04972	0.31547424
86	Long-term potentiation_Homo sapiens_hsa04720	0.31546281
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.30088922
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29825810
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28333684
90	Tight junction_Homo sapiens_hsa04530	0.26952006
91	GABAergic synapse_Homo sapiens_hsa04727	0.25323698
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23421872
93	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.23136177
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.22425197
95	Legionellosis_Homo sapiens_hsa05134	0.22075774
96	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.20730573
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.19785928
98	Alcoholism_Homo sapiens_hsa05034	0.18074063
99	ECM-receptor interaction_Homo sapiens_hsa04512	0.18021880
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.16945696

OR7E104P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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