OR7E106P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 2 cell differentiation (GO:0045628)9.87484315
2activation of protein kinase A activity (GO:0034199)9.81800178
3regulation of T-helper 1 cell differentiation (GO:0045625)9.62816802
4negative regulation of type 2 immune response (GO:0002829)9.48127581
5seminiferous tubule development (GO:0072520)9.40293130
6positive regulation of RNA splicing (GO:0033120)9.08820021
7cAMP biosynthetic process (GO:0006171)8.84345797
8negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.64700317
9detection of chemical stimulus involved in sensory perception (GO:0050907)8.28530898
10negative regulation of alpha-beta T cell differentiation (GO:0046639)7.89297140
11enteric nervous system development (GO:0048484)7.50570719
12dendritic spine morphogenesis (GO:0060997)7.24094870
13regulation of protein sumoylation (GO:0033233)6.95465492
14synaptic transmission, dopaminergic (GO:0001963)6.65693992
15positive regulation of mitochondrial fission (GO:0090141)6.51035223
16righting reflex (GO:0060013)6.38436747
17heterotypic cell-cell adhesion (GO:0034113)6.19793312
18endothelial cell differentiation (GO:0045446)6.15809297
19arachidonic acid secretion (GO:0050482)6.12292025
20icosanoid secretion (GO:0032309)6.12292025
21positive regulation of T-helper 1 type immune response (GO:0002827)5.99312460
22detection of chemical stimulus (GO:0009593)5.95541170
23hepatocyte apoptotic process (GO:0097284)5.71633093
24positive regulation of T-helper cell differentiation (GO:0045624)5.65485084
25drug transmembrane transport (GO:0006855)5.31929528
26phosphatidylinositol acyl-chain remodeling (GO:0036149)5.09691247
27fatty acid derivative transport (GO:1901571)5.08071935
28icosanoid transport (GO:0071715)5.08071935
29phosphatidylserine acyl-chain remodeling (GO:0036150)4.85470709
30neuronal ion channel clustering (GO:0045161)4.81620469
31nephron tubule morphogenesis (GO:0072078)4.78588249
32nephron epithelium morphogenesis (GO:0072088)4.78588249
33negative regulation of actin filament bundle assembly (GO:0032232)4.72065783
34neural tube formation (GO:0001841)4.68589703
35regulation of mitochondrial fission (GO:0090140)4.67557107
36phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.66524496
37hyaluronan catabolic process (GO:0030214)4.60271956
38cilium or flagellum-dependent cell motility (GO:0001539)4.59825562
39chemosensory behavior (GO:0007635)4.59043284
40negative regulation of alpha-beta T cell activation (GO:0046636)4.52591976
41vocalization behavior (GO:0071625)4.48133597
42embryonic digestive tract morphogenesis (GO:0048557)4.47475124
43cyclic purine nucleotide metabolic process (GO:0052652)4.38728236
44cyclic nucleotide biosynthetic process (GO:0009190)4.34950377
45positive regulation of membrane potential (GO:0045838)4.30062686
46positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.27193830
47regulation of T-helper 1 type immune response (GO:0002825)4.26363735
48dendritic spine organization (GO:0097061)4.22634522
49retina layer formation (GO:0010842)4.21767787
50cAMP metabolic process (GO:0046058)4.09267031
51regulation of T-helper cell differentiation (GO:0045622)4.08650348
52regulation of cAMP-mediated signaling (GO:0043949)4.02690797
53cellular response to glucagon stimulus (GO:0071377)4.02367373
54regulation of type 2 immune response (GO:0002828)3.99544474
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.99248945
56water transport (GO:0006833)3.98981763
57attachment of spindle microtubules to kinetochore (GO:0008608)3.94261634
58cellular zinc ion homeostasis (GO:0006882)3.92650157
59energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.91237940
60ATP hydrolysis coupled proton transport (GO:0015991)3.91237940
61drug transport (GO:0015893)3.82935847
62response to dietary excess (GO:0002021)3.82058919
63protein localization to synapse (GO:0035418)3.80103074
64positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.75759232
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.69002105
66positive regulation of protein targeting to membrane (GO:0090314)3.67711108
67leukotriene biosynthetic process (GO:0019370)3.64846198
68negative regulation of T cell differentiation (GO:0045581)3.62673727
69fluid transport (GO:0042044)3.54462185
70mitochondrial fusion (GO:0008053)3.53133476
71left/right axis specification (GO:0070986)3.52251411
72cellular response to ATP (GO:0071318)3.46477556
73monoamine transport (GO:0015844)3.43457332
74renal tubule morphogenesis (GO:0061333)3.41223975
75phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.37205212
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30429626
77neurofilament cytoskeleton organization (GO:0060052)3.23732478
78pre-miRNA processing (GO:0031054)3.23255128
79sequestering of metal ion (GO:0051238)3.22837016
80regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.20045116
81sulfur amino acid catabolic process (GO:0000098)3.20042584
82positive regulation of alpha-beta T cell differentiation (GO:0046638)3.18187848
83positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.17589555
84negative regulation of homotypic cell-cell adhesion (GO:0034111)3.14537378
85positive regulation of dendritic spine development (GO:0060999)3.14492513
86adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.13143280
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12298455
88response to auditory stimulus (GO:0010996)3.07468136
89axonemal dynein complex assembly (GO:0070286)3.06998822
90prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.06635438
91response to glucagon (GO:0033762)3.04105659
92adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.03036100
93zinc ion homeostasis (GO:0055069)3.00203839
94single fertilization (GO:0007338)2.95300292
95tooth mineralization (GO:0034505)13.9853290
96detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.3449204
97positive regulation of protein sumoylation (GO:0033235)11.1965079
98negative regulation of T-helper cell differentiation (GO:0045623)10.7318719
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)10.7318719
100protein K11-linked deubiquitination (GO:0035871)10.1815164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.63894642
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.24438547
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.21220918
4AR_21572438_ChIP-Seq_LNCaP_Human4.50383820
5IGF1R_20145208_ChIP-Seq_DFB_Human4.37780932
6VDR_22108803_ChIP-Seq_LS180_Human3.99144012
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.10834874
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.90105953
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90105953
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.87731645
11PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86780755
12ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86632258
13GATA1_19941826_ChIP-Seq_K562_Human1.84560730
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82399488
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.76681393
16TP53_16413492_ChIP-PET_HCT116_Human1.76333894
17DROSHA_22980978_ChIP-Seq_HELA_Human1.68459623
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67823988
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.56547523
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.53751818
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52629313
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51539927
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45087510
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44703258
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43820787
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43193367
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.40310344
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.40290986
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.37324156
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.35856789
31RNF2_27304074_Chip-Seq_NSC_Mouse1.35194819
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33739883
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30684495
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26121934
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.21222682
36EGR1_19032775_ChIP-ChIP_M12_Human1.21216209
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20658024
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.20467541
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19855160
40RXR_22108803_ChIP-Seq_LS180_Human1.19678316
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19582895
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.19360125
43ER_23166858_ChIP-Seq_MCF-7_Human1.14545034
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14489702
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14333490
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14331574
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14119395
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.13254423
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.12529644
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10313542
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09757543
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08803519
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.08243876
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06922628
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06235156
56TBL1_22424771_ChIP-Seq_293T_Human1.05757964
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05224421
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.04526671
59SMAD4_21741376_ChIP-Seq_HESCs_Human1.03454885
60CJUN_26792858_Chip-Seq_BT549_Human1.02999235
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.01070600
62EZH2_22144423_ChIP-Seq_EOC_Human0.99622561
63CTCF_27219007_Chip-Seq_Bcells_Human0.99043287
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98644593
65PHF8_20622853_ChIP-Seq_HELA_Human0.98464154
66SOX2_18555785_Chip-Seq_ESCs_Mouse0.97458833
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96347428
68RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96143030
69EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96143030
70DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96041100
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94008054
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92757583
73CBP_20019798_ChIP-Seq_JUKART_Human0.92290946
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92290946
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92125327
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89778868
77CMYC_18555785_Chip-Seq_ESCs_Mouse0.88738585
78STAT3_23295773_ChIP-Seq_U87_Human0.87697657
79GBX2_23144817_ChIP-Seq_PC3_Human0.87523959
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87079034
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86604156
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86079541
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.85727474
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84973130
85BCAT_22108803_ChIP-Seq_LS180_Human0.83868405
86SMAD4_21741376_ChIP-Seq_EPCs_Human0.83257830
87NANOG_20526341_ChIP-Seq_ESCs_Human0.82633873
88RING1B_27294783_Chip-Seq_ESCs_Mouse0.81885009
89SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80774355
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80588082
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80534439
92ETV1_20927104_ChIP-Seq_GIST48_Human0.80391372
93SMAD4_21799915_ChIP-Seq_A2780_Human0.80176706
94NMYC_18555785_Chip-Seq_ESCs_Mouse0.80157549
95E2F1_18555785_Chip-Seq_ESCs_Mouse0.79909327
96TP53_18474530_ChIP-ChIP_U2OS_Human0.79198204
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.78485102
98REST_21632747_ChIP-Seq_MESCs_Mouse0.78050894
99KLF4_18555785_Chip-Seq_ESCs_Mouse0.78033385
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77620071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.11496414
2MP0004130_abnormal_muscle_cell4.56840443
3MP0003252_abnormal_bile_duct3.79546495
4MP0004264_abnormal_extraembryonic_tissu3.69731757
5MP0002928_abnormal_bile_duct3.50226101
6MP0004133_heterotaxia2.52940595
7MP0006072_abnormal_retinal_apoptosis2.43280730
8MP0001270_distended_abdomen2.16170745
9MP0005448_abnormal_energy_balance2.09249177
10MP0004272_abnormal_basement_membrane2.05504807
11MP0005084_abnormal_gallbladder_morpholo12.9708096
12MP0005408_hypopigmentation1.95470426
13MP0002751_abnormal_autonomic_nervous1.82547948
14MP0003329_amyloid_beta_deposits1.75633918
15MP0003943_abnormal_hepatobiliary_system1.69192790
16MP0005379_endocrine/exocrine_gland_phen1.51054402
17MP0005165_increased_susceptibility_to1.50128812
18MP0003718_maternal_effect1.41177041
19MP0009764_decreased_sensitivity_to1.40166240
20MP0003638_abnormal_response/metabolism_1.32424927
21MP0005220_abnormal_exocrine_pancreas1.29891117
22MP0003878_abnormal_ear_physiology1.22112542
23MP0005377_hearing/vestibular/ear_phenot1.22112542
24MP0005410_abnormal_fertilization1.19020544
25MP0001529_abnormal_vocalization1.11260880
26MP0002405_respiratory_system_inflammati1.07695936
27MP0000604_amyloidosis1.07489641
28MP0001958_emphysema1.06818620
29MP0000465_gastrointestinal_hemorrhage1.06108548
30MP0000470_abnormal_stomach_morphology1.06086540
31MP0005646_abnormal_pituitary_gland0.96012392
32MP0001851_eye_inflammation0.93513746
33MP0001905_abnormal_dopamine_level0.92562036
34MP0002098_abnormal_vibrissa_morphology0.90942921
35MP0002572_abnormal_emotion/affect_behav0.90167805
36MP0001944_abnormal_pancreas_morphology0.87294858
37MP0008569_lethality_at_weaning0.85645502
38MP0005164_abnormal_response_to0.84220232
39MP0008469_abnormal_protein_level0.81275968
40MP0001800_abnormal_humoral_immune0.77706817
41MP0001533_abnormal_skeleton_physiology0.68333070
42MP0000371_diluted_coat_color0.65876815
43MP0010234_abnormal_vibrissa_follicle0.65232610
44MP0003866_abnormal_defecation0.64417667
45MP0000703_abnormal_thymus_morphology0.64408797
46MP0002136_abnormal_kidney_physiology0.63891099
47MP0008875_abnormal_xenobiotic_pharmacok0.63726808
48MP0005253_abnormal_eye_physiology0.63461652
49MP0005387_immune_system_phenotype0.63050825
50MP0001790_abnormal_immune_system0.63050825
51MP0000609_abnormal_liver_physiology0.62385517
52MP0004947_skin_inflammation0.61661191
53MP0001879_abnormal_lymphatic_vessel0.61193735
54MP0001501_abnormal_sleep_pattern0.60477246
55MP0002693_abnormal_pancreas_physiology0.57722174
56MP0001915_intracranial_hemorrhage0.57539336
57MP0002909_abnormal_adrenal_gland0.56925633
58MP0005551_abnormal_eye_electrophysiolog0.55486004
59MP0002998_abnormal_bone_remodeling0.53321418
60MP0004019_abnormal_vitamin_homeostasis0.53124755
61MP0001845_abnormal_inflammatory_respons0.53107480
62MP0009053_abnormal_anal_canal0.52237644
63MP0002078_abnormal_glucose_homeostasis0.50921557
64MP0003953_abnormal_hormone_level0.50402589
65MP0002722_abnormal_immune_system0.50120754
66MP0002735_abnormal_chemical_nociception0.49310510
67MP0003724_increased_susceptibility_to0.48461011
68MP0003121_genomic_imprinting0.46962805
69MP0002419_abnormal_innate_immunity0.46730879
70MP0004484_altered_response_of0.44817338
71MP0000249_abnormal_blood_vessel0.43511836
72MP0004885_abnormal_endolymph0.42610457
73MP0009642_abnormal_blood_homeostasis0.41094918
74MP0010368_abnormal_lymphatic_system0.40130135
75MP0000477_abnormal_intestine_morphology0.38540130
76MP0008004_abnormal_stomach_pH0.38449550
77MP0005423_abnormal_somatic_nervous0.37154798
78MP0005334_abnormal_fat_pad0.36990839
79MP0002429_abnormal_blood_cell0.36811400
80MP0002723_abnormal_immune_serum0.36713391
81MP0002420_abnormal_adaptive_immunity0.36615312
82MP0003195_calcinosis0.35835023
83MP0002452_abnormal_antigen_presenting0.35675744
84MP0002161_abnormal_fertility/fecundity0.35370041
85MP0001819_abnormal_immune_cell0.35279249
86MP0009785_altered_susceptibility_to0.34992220
87MP0002822_catalepsy0.34403678
88MP0000598_abnormal_liver_morphology0.34041076
89MP0005390_skeleton_phenotype0.33458165
90MP0000716_abnormal_immune_system0.32452923
91MP0002398_abnormal_bone_marrow0.32287625
92MP0005395_other_phenotype0.31419846
93MP0003698_abnormal_male_reproductive0.30578691
94MP0009931_abnormal_skin_appearance0.30476791
95MP0002229_neurodegeneration0.29437091
96MP0000920_abnormal_myelination0.29310195
97MP0005000_abnormal_immune_tolerance0.28656811
98MP0002882_abnormal_neuron_morphology0.28074575
99MP0003879_abnormal_hair_cell0.27929045
100MP0000689_abnormal_spleen_morphology0.27341844

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.49697671
2Abnormality of dental color (HP:0011073)8.39136375
3Polyuria (HP:0000103)7.99759760
4Abnormality of renal resorption (HP:0011038)7.77961010
5Osteomalacia (HP:0002749)7.45378533
6Abnormal urine output (HP:0012590)6.94247540
7Abnormality of the dental pulp (HP:0006479)6.87349278
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.60995189
9Abnormality of renal excretion (HP:0011036)6.04318765
10Round ear (HP:0100830)4.93886993
11Chronic bronchitis (HP:0004469)4.61694060
12Volvulus (HP:0002580)4.09487665
13Autoimmune thrombocytopenia (HP:0001973)4.09198306
14IgM deficiency (HP:0002850)3.97779499
15Abnormality of midbrain morphology (HP:0002418)3.81386966
16Molar tooth sign on MRI (HP:0002419)3.81386966
17Lip pit (HP:0100267)3.70062479
18Toxemia of pregnancy (HP:0100603)3.68134593
19Esophageal varix (HP:0002040)3.66968442
20Nephrocalcinosis (HP:0000121)3.62245160
21Rhinitis (HP:0012384)3.56096970
22Abnormal respiratory motile cilium physiology (HP:0012261)3.44674920
23Sparse lateral eyebrow (HP:0005338)3.20337992
24Nephronophthisis (HP:0000090)3.15708442
25Large earlobe (HP:0009748)3.06603528
26Lipoatrophy (HP:0100578)3.04577216
27Hypoparathyroidism (HP:0000829)3.02317315
28Hyperphosphaturia (HP:0003109)3.01905794
29Tachypnea (HP:0002789)2.99465461
30Depressed nasal tip (HP:0000437)2.99389168
31Intestinal fistula (HP:0100819)2.96000667
32Thick eyebrow (HP:0000574)2.82937015
33Drooling (HP:0002307)2.74468383
34Abnormality of the renal medulla (HP:0100957)2.70294976
35Excessive salivation (HP:0003781)2.62671124
36Panhypogammaglobulinemia (HP:0003139)2.60328060
37Abnormal urine phosphate concentration (HP:0012599)2.53826485
38Inability to walk (HP:0002540)2.47932608
39Personality changes (HP:0000751)2.41888285
40Hepatitis (HP:0012115)2.30944617
41Nephropathy (HP:0000112)2.29382894
42Abnormality of urine glucose concentration (HP:0011016)2.28553544
43Glycosuria (HP:0003076)2.28553544
44Petechiae (HP:0000967)2.25762261
45Gingival overgrowth (HP:0000212)2.25339399
46Hypercalciuria (HP:0002150)2.24684072
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.24293732
48Ureteral stenosis (HP:0000071)2.21976366
49Stage 5 chronic kidney disease (HP:0003774)2.19584959
50Preauricular pit (HP:0004467)2.19270102
51Periauricular skin pits (HP:0100277)2.19270102
52Abnormality of transition element cation homeostasis (HP:0011030)2.16152986
53Short 5th finger (HP:0009237)2.15213405
54Dilated cardiomyopathy (HP:0001644)2.14763315
55Bronchitis (HP:0012387)2.12036756
56Anal stenosis (HP:0002025)2.09427593
57Sudden cardiac death (HP:0001645)2.08159321
58Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.05134284
59Ureteral obstruction (HP:0006000)2.00132935
60Overgrowth (HP:0001548)11.3818619
61Amelogenesis imperfecta (HP:0000705)11.0498315
62Chondrocalcinosis (HP:0000934)1.99672179
63Chronic mucocutaneous candidiasis (HP:0002728)1.96008158
64Recurrent cutaneous fungal infections (HP:0011370)1.96008158
65Abnormality of the fingertips (HP:0001211)1.94884004
66Abnormality of Sharpey fibers (HP:0100685)1.94139369
67Recurrent otitis media (HP:0000403)1.92774429
68Colitis (HP:0002583)1.92527432
69Striae distensae (HP:0001065)1.87760627
70Delayed eruption of teeth (HP:0000684)1.82930906
71Abnormality of salivation (HP:0100755)1.79716546
72Chorioretinal coloboma (HP:0000567)1.76559222
73Agammaglobulinemia (HP:0004432)1.73548055
74Ectopic kidney (HP:0000086)1.70124808
75Hypotrichosis (HP:0001006)1.69613694
76Renal tubular dysfunction (HP:0000124)1.69593559
77Decreased muscle mass (HP:0003199)1.68778147
78Prominent supraorbital ridges (HP:0000336)1.63760481
79Bronchiectasis (HP:0002110)1.61182935
80Facial shape deformation (HP:0011334)1.60503556
81Potter facies (HP:0002009)1.60503556
82Truncal ataxia (HP:0002078)1.55508707
83Polyneuropathy (HP:0001271)1.55401316
84Limited elbow extension (HP:0001377)1.51266995
85Small hand (HP:0200055)1.49499522
86Preauricular skin tag (HP:0000384)1.48762754
87Skin pits (HP:0100276)1.47946897
88Congenital sensorineural hearing impairment (HP:0008527)1.45478459
89Attenuation of retinal blood vessels (HP:0007843)1.42751153
90Aplasia/Hypoplasia of the earlobes (HP:0009906)1.41809079
91Osteoarthritis (HP:0002758)1.40243372
92Ectropion (HP:0000656)1.38747962
93Oculomotor apraxia (HP:0000657)1.38040482
94Bony spicule pigmentary retinopathy (HP:0007737)1.36166822
95Palmoplantar keratoderma (HP:0000982)1.36072234
96Hypokalemic alkalosis (HP:0001949)1.35386500
97Prenatal maternal abnormality (HP:0002686)1.34784061
98Torticollis (HP:0000473)1.34334906
99Abnormality of sodium homeostasis (HP:0010931)1.29533971
100Blepharitis (HP:0000498)1.29507623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.50314729
2BLK4.01107515
3STK33.71615940
4RIPK43.22547495
5CDC42BPA2.06827202
6BMPR22.03428856
7NTRK213.3256167
8MAPK151.98251288
9TIE11.92220787
10TSSK61.91009700
11HIPK21.02841390
12INSRR0.98565259
13STK390.95897326
14PRKCQ0.93885067
15WNK40.88500868
16MAP4K20.82836331
17FGFR10.80007639
18PLK40.78299756
19GRK60.75607913
20DDR20.70612403
21PRKD30.67591455
22MAP3K140.65929169
23SYK0.64627064
24ROCK20.63155490
25MAP2K20.62291939
26OBSCN0.61290942
27SRC0.59203190
28TXK0.58774847
29MUSK0.55346085
30ZAK0.52420296
31ADRBK20.50088465
32OXSR10.48511963
33ROCK10.47387704
34MATK0.47099326
35GRK10.46909283
36PRKAA10.45348631
37TLK10.43538969
38TEC0.43083639
39PRKACG0.39538528
40GRK70.39002467
41PRKACB0.38946649
42CAMK2A0.38146025
43ABL10.37242471
44DAPK20.34142237
45PRKACA0.33974292
46EPHB20.33635230
47WNK30.31077924
48KIT0.31058036
49PIK3CG0.30071057
50PIM10.28918856
51MST1R0.28573629
52MAP3K30.28564605
53ERBB40.26661854
54MAPK140.24457948
55TAOK30.23841699
56GSK3B0.22699171
57MAPK70.22630825
58PRKCA0.22503581
59CDK30.22469595
60CAMK2G0.22117479
61CAMKK10.21911497
62RPS6KA30.20686243
63PKN10.20197368
64PNCK0.20176306
65ITK0.20004787
66KDR0.19335165
67LYN0.18791921
68PLK10.18363145
69BTK0.17674646
70EGFR0.17085792
71PRKCD0.16596136
72RPS6KA50.16043720
73PRKCB0.15892744
74FYN0.15827013
75PIK3CA0.15682847
76PRKCG0.15636547
77MAPK90.15494784
78EPHA40.15067594
79CDK10.14618720
80CAMK2D0.14452549
81PRKG10.14412554
82MAP3K20.14286976
83BCKDK0.13612817
84PDK20.12476301
85PINK10.11794493
86VRK10.11726730
87AKT10.11532690
88LCK0.11143591
89EPHA20.10756897
90TESK10.10056828
91CSNK1A10.10035778
92CAMK2B0.10020682
93MAP2K60.09579532
94IGF1R0.08557172
95ADRBK10.08373100
96PIM20.07583238
97LMTK20.06526013
98PAK20.06364752
99MAPK120.06328446
100STK38L0.05983499

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.37042611
2Sulfur relay system_Homo sapiens_hsa041223.44265002
3Sulfur metabolism_Homo sapiens_hsa009203.29497636
4Ovarian steroidogenesis_Homo sapiens_hsa049133.27215440
5Longevity regulating pathway - multiple species_Homo sapiens_hsa042133.02805912
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91119006
7Linoleic acid metabolism_Homo sapiens_hsa005912.72880939
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.59184614
9Bile secretion_Homo sapiens_hsa049762.57876089
10Collecting duct acid secretion_Homo sapiens_hsa049662.26486700
11Gastric acid secretion_Homo sapiens_hsa049712.18628507
12Vibrio cholerae infection_Homo sapiens_hsa051102.18097668
13Pancreatic secretion_Homo sapiens_hsa049722.14270317
14Salivary secretion_Homo sapiens_hsa049702.13795088
15Thyroid hormone synthesis_Homo sapiens_hsa049182.12961351
16Fat digestion and absorption_Homo sapiens_hsa049752.00546434
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99691636
18Circadian entrainment_Homo sapiens_hsa047131.92495021
19Synaptic vesicle cycle_Homo sapiens_hsa047211.86274231
20Cocaine addiction_Homo sapiens_hsa050301.83648029
21Insulin secretion_Homo sapiens_hsa049111.83025418
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78303021
23Morphine addiction_Homo sapiens_hsa050321.74325191
24Taste transduction_Homo sapiens_hsa047421.72159365
25Glutamatergic synapse_Homo sapiens_hsa047241.70422001
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.69458980
27GABAergic synapse_Homo sapiens_hsa047271.68477723
28Ether lipid metabolism_Homo sapiens_hsa005651.56368218
29Dilated cardiomyopathy_Homo sapiens_hsa054141.54875964
30Gap junction_Homo sapiens_hsa045401.53642218
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50593862
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.49959419
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43329895
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40502572
35GnRH signaling pathway_Homo sapiens_hsa049121.38331845
36Amphetamine addiction_Homo sapiens_hsa050311.37958024
37Circadian rhythm_Homo sapiens_hsa047101.35376369
38Estrogen signaling pathway_Homo sapiens_hsa049151.29894003
39Arachidonic acid metabolism_Homo sapiens_hsa005901.27095142
40Melanogenesis_Homo sapiens_hsa049161.26564391
41Oxytocin signaling pathway_Homo sapiens_hsa049211.19649377
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18087058
43Dorso-ventral axis formation_Homo sapiens_hsa043201.12721653
44Cholinergic synapse_Homo sapiens_hsa047251.11234441
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10927499
46Platelet activation_Homo sapiens_hsa046111.06368257
47Calcium signaling pathway_Homo sapiens_hsa040201.06219867
48Prion diseases_Homo sapiens_hsa050200.82274633
49Oocyte meiosis_Homo sapiens_hsa041140.77156213
50Chemokine signaling pathway_Homo sapiens_hsa040620.76235203
51Serotonergic synapse_Homo sapiens_hsa047260.75331480
52Rheumatoid arthritis_Homo sapiens_hsa053230.72073342
53ECM-receptor interaction_Homo sapiens_hsa045120.70861378
54Pyruvate metabolism_Homo sapiens_hsa006200.66603940
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59863460
56cAMP signaling pathway_Homo sapiens_hsa040240.51803991
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50578683
58RNA degradation_Homo sapiens_hsa030180.46406645
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.44354386
60African trypanosomiasis_Homo sapiens_hsa051430.42662465
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.39173749
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.37803952
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.36736522
64Alcoholism_Homo sapiens_hsa050340.36464029
65Primary immunodeficiency_Homo sapiens_hsa053400.36002307
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34433570
67Phototransduction_Homo sapiens_hsa047440.32036762
68Dopaminergic synapse_Homo sapiens_hsa047280.30894471
69Retinol metabolism_Homo sapiens_hsa008300.30602915
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29708522
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28025259
72Rap1 signaling pathway_Homo sapiens_hsa040150.27843107
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.24284788
74Purine metabolism_Homo sapiens_hsa002300.23208626
75Staphylococcus aureus infection_Homo sapiens_hsa051500.23001279
76Caffeine metabolism_Homo sapiens_hsa002320.21434242
77Glucagon signaling pathway_Homo sapiens_hsa049220.19822769
78Hedgehog signaling pathway_Homo sapiens_hsa043400.19100101
79Antigen processing and presentation_Homo sapiens_hsa046120.18988627
80Type I diabetes mellitus_Homo sapiens_hsa049400.18335856
81Ras signaling pathway_Homo sapiens_hsa040140.17775387
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.15453496
83B cell receptor signaling pathway_Homo sapiens_hsa046620.11804751
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11744586
85Hematopoietic cell lineage_Homo sapiens_hsa046400.11624872
86HTLV-I infection_Homo sapiens_hsa051660.11209719
87Systemic lupus erythematosus_Homo sapiens_hsa053220.11167758
88Phagosome_Homo sapiens_hsa041450.11133636
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10778687
90Nicotine addiction_Homo sapiens_hsa050330.09108930
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.08855278
92Malaria_Homo sapiens_hsa051440.08641795
93Renin secretion_Homo sapiens_hsa049240.08171124
94Nitrogen metabolism_Homo sapiens_hsa009100.07899601
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.07200085
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.07186358
97ABC transporters_Homo sapiens_hsa020100.06699066
98Autoimmune thyroid disease_Homo sapiens_hsa053200.06683553
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06622893
100Parkinsons disease_Homo sapiens_hsa050120.06413509

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