OR7E109P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)9.98117097
2regulation of T-helper 2 cell differentiation (GO:0045628)9.78372716
3regulation of T-helper 1 cell differentiation (GO:0045625)9.69175601
4activation of protein kinase A activity (GO:0034199)9.53910172
5negative regulation of type 2 immune response (GO:0002829)9.31882530
6negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.97334604
7seminiferous tubule development (GO:0072520)8.89482280
8positive regulation of RNA splicing (GO:0033120)8.69306335
9negative regulation of alpha-beta T cell differentiation (GO:0046639)8.29501197
10detection of chemical stimulus involved in sensory perception (GO:0050907)8.10996217
11cAMP biosynthetic process (GO:0006171)7.97126434
12enteric nervous system development (GO:0048484)7.30572677
13synaptic transmission, dopaminergic (GO:0001963)6.96165159
14regulation of protein sumoylation (GO:0033233)6.79479887
15positive regulation of mitochondrial fission (GO:0090141)6.60040999
16dendritic spine morphogenesis (GO:0060997)6.50656334
17righting reflex (GO:0060013)6.40316933
18icosanoid secretion (GO:0032309)6.13077453
19arachidonic acid secretion (GO:0050482)6.13077453
20heterotypic cell-cell adhesion (GO:0034113)6.12330270
21positive regulation of T-helper 1 type immune response (GO:0002827)6.07949619
22detection of chemical stimulus (GO:0009593)5.81670379
23hepatocyte apoptotic process (GO:0097284)5.73871081
24endothelial cell differentiation (GO:0045446)5.49657100
25positive regulation of T-helper cell differentiation (GO:0045624)5.49111022
26phosphatidylinositol acyl-chain remodeling (GO:0036149)5.47658863
27regulation of mitochondrial fission (GO:0090140)5.06746585
28icosanoid transport (GO:0071715)5.05843350
29fatty acid derivative transport (GO:1901571)5.05843350
30phosphatidylserine acyl-chain remodeling (GO:0036150)5.04556025
31chemosensory behavior (GO:0007635)5.01338220
32negative regulation of alpha-beta T cell activation (GO:0046636)4.93066073
33drug transmembrane transport (GO:0006855)4.86557142
34phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.85965364
35neuronal ion channel clustering (GO:0045161)4.69689732
36cilium or flagellum-dependent cell motility (GO:0001539)4.57091445
37regulation of T-helper 1 type immune response (GO:0002825)4.51509518
38neural tube formation (GO:0001841)4.50485243
39vocalization behavior (GO:0071625)4.39967312
40energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.30062229
41ATP hydrolysis coupled proton transport (GO:0015991)4.30062229
42retina layer formation (GO:0010842)4.28774793
43negative regulation of cytosolic calcium ion concentration (GO:0051481)4.27054705
44hyaluronan catabolic process (GO:0030214)4.26985949
45nephron tubule morphogenesis (GO:0072078)4.25164522
46nephron epithelium morphogenesis (GO:0072088)4.25164522
47cyclic purine nucleotide metabolic process (GO:0052652)4.21161202
48regulation of cAMP-mediated signaling (GO:0043949)4.19171401
49embryonic digestive tract morphogenesis (GO:0048557)4.16794130
50positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.11852366
51cyclic nucleotide biosynthetic process (GO:0009190)4.10230443
52regulation of T-helper cell differentiation (GO:0045622)4.07455352
53water transport (GO:0006833)4.04063030
54negative regulation of actin filament bundle assembly (GO:0032232)4.03319346
55cellular response to glucagon stimulus (GO:0071377)4.02285144
56protein localization to synapse (GO:0035418)3.95012309
57negative regulation of T cell differentiation (GO:0045581)3.92972657
58negative regulation of homotypic cell-cell adhesion (GO:0034111)3.90688834
59positive regulation of membrane potential (GO:0045838)3.89750554
60regulation of type 2 immune response (GO:0002828)3.84767175
61response to dietary excess (GO:0002021)3.80834810
62monoamine transport (GO:0015844)3.76813612
63leukotriene biosynthetic process (GO:0019370)3.74641015
64cAMP metabolic process (GO:0046058)3.64033510
65positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.61123892
66phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.60181951
67attachment of spindle microtubules to kinetochore (GO:0008608)3.59699666
68fluid transport (GO:0042044)3.59402932
69dendritic spine organization (GO:0097061)3.55738187
70cellular response to ATP (GO:0071318)3.55638460
71mitochondrial fusion (GO:0008053)3.52180343
72sulfur amino acid catabolic process (GO:0000098)3.32812218
73cellular zinc ion homeostasis (GO:0006882)3.32607102
74regulation of platelet aggregation (GO:0090330)3.27523912
75drug transport (GO:0015893)3.26568224
76sequestering of metal ion (GO:0051238)3.21379945
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.19066628
78positive regulation of steroid hormone secretion (GO:2000833)3.17457388
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.15542492
80neurofilament cytoskeleton organization (GO:0060052)3.15275781
81positive regulation of protein targeting to membrane (GO:0090314)3.13963490
82response to auditory stimulus (GO:0010996)3.13354782
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12331135
84adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.11429855
85renal tubule morphogenesis (GO:0061333)3.07152745
86phosphatidylcholine acyl-chain remodeling (GO:0036151)3.06710938
87negative regulation of platelet activation (GO:0010544)3.05676370
88reflex (GO:0060004)3.03161631
89positive regulation of alpha-beta T cell differentiation (GO:0046638)3.01921250
90neuromuscular process controlling posture (GO:0050884)3.01893319
91positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.00822391
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.99744832
93regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.99744832
94activation of phospholipase C activity (GO:0007202)2.97142883
95adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.94422762
96tooth mineralization (GO:0034505)13.1357114
97detection of chemical stimulus involved in sensory perception of smell (GO:0050911)12.8755844
98negative regulation of T-helper cell differentiation (GO:0045623)11.1899776
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.1899776
100positive regulation of protein sumoylation (GO:0033235)10.9687626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.96517402
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.13341957
3IGF1R_20145208_ChIP-Seq_DFB_Human4.72307807
4AR_21572438_ChIP-Seq_LNCaP_Human4.59094866
5VDR_22108803_ChIP-Seq_LS180_Human4.45591595
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.20596718
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.09561887
8TP53_16413492_ChIP-PET_HCT116_Human2.15348528
9EZH2_22144423_ChIP-Seq_EOC_Human2.10160277
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.05062920
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97699048
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94171249
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94171249
14YY1_22570637_ChIP-Seq_MALME-3M_Human1.92897257
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88286162
16GATA1_19941826_ChIP-Seq_K562_Human1.84425848
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72395218
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60245708
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55732619
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.53143367
21DROSHA_22980978_ChIP-Seq_HELA_Human1.52555617
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51102803
23EGR1_19032775_ChIP-ChIP_M12_Human1.47022486
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46484065
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44251408
26ZNF274_21170338_ChIP-Seq_K562_Hela1.44192612
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.43224565
28GBX2_23144817_ChIP-Seq_PC3_Human1.42217413
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42117113
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41706236
31SMAD3_21741376_ChIP-Seq_HESCs_Human1.39864564
32RNF2_27304074_Chip-Seq_NSC_Mouse1.37811972
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.35373040
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30046203
35ER_23166858_ChIP-Seq_MCF-7_Human1.27563409
36RXR_22108803_ChIP-Seq_LS180_Human1.26666298
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24063474
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.23069724
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.20476500
40PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20232967
41TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.19565149
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18113405
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14521121
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13050827
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12217344
46BCAT_22108803_ChIP-Seq_LS180_Human1.11967622
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.11437900
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10931077
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10903950
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10903931
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10826410
52TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09787845
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09538634
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.08925317
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.08069487
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06875422
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05853903
58STAT3_23295773_ChIP-Seq_U87_Human1.04273215
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.04237270
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04118804
61GATA6_21074721_ChIP-Seq_CACO-2_Human1.02539743
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.01661269
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.01412806
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.00843926
65SMAD4_21741376_ChIP-Seq_HESCs_Human0.99939372
66HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98249815
67TBL1_22424771_ChIP-Seq_293T_Human0.97693276
68CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96800958
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96473229
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96267953
71NANOG_20526341_ChIP-Seq_ESCs_Human0.96156303
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95388887
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94348507
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94166877
75CMYC_18555785_Chip-Seq_ESCs_Mouse0.94002259
76PHF8_20622853_ChIP-Seq_HELA_Human0.93328602
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92223776
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90987185
79AR_25329375_ChIP-Seq_VCAP_Human0.90848942
80REST_21632747_ChIP-Seq_MESCs_Mouse0.90071758
81ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89693338
82HTT_18923047_ChIP-ChIP_STHdh_Human0.87926491
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87580804
84SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87480320
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87029141
86SMAD4_21799915_ChIP-Seq_A2780_Human0.86655094
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.85866757
88CJUN_26792858_Chip-Seq_BT549_Human0.84450825
89P53_22387025_ChIP-Seq_ESCs_Mouse0.83505493
90GATA2_19941826_ChIP-Seq_K562_Human0.83356312
91KLF4_18555785_Chip-Seq_ESCs_Mouse0.83217898
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82942218
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.82821954
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.82230804
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82141668
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.82111247
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.80319411
98TCF4_22108803_ChIP-Seq_LS180_Human0.79863803
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.79677249
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79141494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.06517909
2MP0004130_abnormal_muscle_cell5.02571200
3MP0003252_abnormal_bile_duct3.47354242
4MP0004264_abnormal_extraembryonic_tissu3.17116170
5MP0004133_heterotaxia2.75893314
6MP0006072_abnormal_retinal_apoptosis2.65599873
7MP0002928_abnormal_bile_duct2.41886321
8MP0005448_abnormal_energy_balance2.34539546
9MP0002751_abnormal_autonomic_nervous2.16071939
10MP0005084_abnormal_gallbladder_morpholo12.0226626
11MP0005408_hypopigmentation1.96062622
12MP0003329_amyloid_beta_deposits1.83128012
13MP0001270_distended_abdomen1.78205827
14MP0001529_abnormal_vocalization1.74815353
15MP0009764_decreased_sensitivity_to1.68728921
16MP0004272_abnormal_basement_membrane1.67838145
17MP0005646_abnormal_pituitary_gland1.58328133
18MP0003718_maternal_effect1.53651092
19MP0003943_abnormal_hepatobiliary_system1.47119825
20MP0005165_increased_susceptibility_to1.44127679
21MP0005379_endocrine/exocrine_gland_phen1.43894969
22MP0005220_abnormal_exocrine_pancreas1.34992601
23MP0002909_abnormal_adrenal_gland1.28060983
24MP0002822_catalepsy1.21415703
25MP0003638_abnormal_response/metabolism_1.20240066
26MP0001905_abnormal_dopamine_level1.11956807
27MP0004147_increased_porphyrin_level1.10996603
28MP0000604_amyloidosis1.05730610
29MP0002572_abnormal_emotion/affect_behav1.05654934
30MP0001958_emphysema1.00214937
31MP0005253_abnormal_eye_physiology0.99177953
32MP0005464_abnormal_platelet_physiology0.96362102
33MP0000465_gastrointestinal_hemorrhage0.94409767
34MP0008875_abnormal_xenobiotic_pharmacok0.93883774
35MP0008569_lethality_at_weaning0.91634095
36MP0001944_abnormal_pancreas_morphology0.87399856
37MP0009379_abnormal_foot_pigmentation0.82753012
38MP0005551_abnormal_eye_electrophysiolog0.81219857
39MP0000470_abnormal_stomach_morphology0.80891671
40MP0006276_abnormal_autonomic_nervous0.80737622
41MP0002735_abnormal_chemical_nociception0.80612088
42MP0005423_abnormal_somatic_nervous0.80458246
43MP0004019_abnormal_vitamin_homeostasis0.79764380
44MP0001800_abnormal_humoral_immune0.79656859
45MP0005164_abnormal_response_to0.77606186
46MP0003866_abnormal_defecation0.75728836
47MP0001533_abnormal_skeleton_physiology0.73618009
48MP0002693_abnormal_pancreas_physiology0.71577385
49MP0008469_abnormal_protein_level0.70604941
50MP0001501_abnormal_sleep_pattern0.70556679
51MP0001851_eye_inflammation0.70116842
52MP0002098_abnormal_vibrissa_morphology0.68704393
53MP0000579_abnormal_nail_morphology0.66856814
54MP0002405_respiratory_system_inflammati0.66080657
55MP0008004_abnormal_stomach_pH0.65190189
56MP0009053_abnormal_anal_canal0.65087780
57MP0003953_abnormal_hormone_level0.64248320
58MP0002078_abnormal_glucose_homeostasis0.63577244
59MP0003195_calcinosis0.62444959
60MP0002136_abnormal_kidney_physiology0.61605088
61MP0001986_abnormal_taste_sensitivity0.60463213
62MP0000609_abnormal_liver_physiology0.57284624
63MP0003136_yellow_coat_color0.55949393
64MP0003011_delayed_dark_adaptation0.55810648
65MP0001790_abnormal_immune_system0.55384710
66MP0005387_immune_system_phenotype0.55384710
67MP0009642_abnormal_blood_homeostasis0.53811132
68MP0000703_abnormal_thymus_morphology0.53127834
69MP0000371_diluted_coat_color0.52963855
70MP0002736_abnormal_nociception_after0.52785650
71MP0003880_abnormal_central_pattern0.51345635
72MP0005167_abnormal_blood-brain_barrier0.50269775
73MP0000372_irregular_coat_pigmentation0.48492421
74MP0002998_abnormal_bone_remodeling0.48142695
75MP0003121_genomic_imprinting0.47890217
76MP0001845_abnormal_inflammatory_respons0.47585678
77MP0004947_skin_inflammation0.47125621
78MP0002277_abnormal_respiratory_mucosa0.46118415
79MP0008872_abnormal_physiological_respon0.44162126
80MP0005365_abnormal_bile_salt0.44119496
81MP0002429_abnormal_blood_cell0.40785277
82MP0001915_intracranial_hemorrhage0.40679663
83MP0002722_abnormal_immune_system0.39463623
84MP0000249_abnormal_blood_vessel0.39410554
85MP0002452_abnormal_antigen_presenting0.39150458
86MP0001664_abnormal_digestion0.38053208
87MP0001970_abnormal_pain_threshold0.38021450
88MP0002723_abnormal_immune_serum0.38013054
89MP0000230_abnormal_systemic_arterial0.37731719
90MP0005645_abnormal_hypothalamus_physiol0.36885411
91MP0002229_neurodegeneration0.36707714
92MP0005391_vision/eye_phenotype0.35495083
93MP0002882_abnormal_neuron_morphology0.34872625
94MP0002420_abnormal_adaptive_immunity0.34258928
95MP0005000_abnormal_immune_tolerance0.33656920
96MP0001819_abnormal_immune_cell0.33265410
97MP0002398_abnormal_bone_marrow0.32967552
98MP0002102_abnormal_ear_morphology0.32765218
99MP0000716_abnormal_immune_system0.32269848
100MP0002332_abnormal_exercise_endurance0.31962329

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.38941958
2Abnormality of renal resorption (HP:0011038)7.88200276
3Abnormality of dental color (HP:0011073)7.71543335
4Polyuria (HP:0000103)7.37088821
5Osteomalacia (HP:0002749)6.95437207
6Abnormality of the dental pulp (HP:0006479)6.54741203
7Abnormal urine output (HP:0012590)6.32252821
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.22309153
9Abnormality of renal excretion (HP:0011036)5.47685982
10Abnormality of midbrain morphology (HP:0002418)4.61515312
11Molar tooth sign on MRI (HP:0002419)4.61515312
12Round ear (HP:0100830)4.49484245
13Chronic bronchitis (HP:0004469)4.29036077
14IgM deficiency (HP:0002850)3.90937428
15Petechiae (HP:0000967)3.89118604
16Depressed nasal tip (HP:0000437)3.77994220
17Autoimmune thrombocytopenia (HP:0001973)3.69979248
18Volvulus (HP:0002580)3.52408911
19Lip pit (HP:0100267)3.51250199
20Abnormal respiratory motile cilium physiology (HP:0012261)3.41194696
21Nephrocalcinosis (HP:0000121)3.37672112
22Toxemia of pregnancy (HP:0100603)3.36437250
23Rhinitis (HP:0012384)3.21556704
24Nephronophthisis (HP:0000090)3.21222181
25Esophageal varix (HP:0002040)3.12809279
26Lipoatrophy (HP:0100578)3.02791702
27Tachypnea (HP:0002789)3.00730365
28Intestinal fistula (HP:0100819)2.93304776
29Panhypogammaglobulinemia (HP:0003139)2.83986847
30Inability to walk (HP:0002540)2.80645969
31Drooling (HP:0002307)2.77534229
32Hyperphosphaturia (HP:0003109)2.77294860
33Abnormality of the fingertips (HP:0001211)2.74050399
34Birth length less than 3rd percentile (HP:0003561)2.74020180
35Hypoparathyroidism (HP:0000829)2.66724682
36Abnormality of transition element cation homeostasis (HP:0011030)2.66366843
37Excessive salivation (HP:0003781)2.63406291
38Glycosuria (HP:0003076)2.49219300
39Abnormality of urine glucose concentration (HP:0011016)2.49219300
40Ureteral stenosis (HP:0000071)2.46947226
41Abnormality of the renal medulla (HP:0100957)2.43310377
42Recurrent cutaneous fungal infections (HP:0011370)2.41650163
43Chronic mucocutaneous candidiasis (HP:0002728)2.41650163
44Sparse lateral eyebrow (HP:0005338)2.34551940
45Nephropathy (HP:0000112)2.34424644
46Dilated cardiomyopathy (HP:0001644)2.33978140
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.33058040
48Abnormal urine phosphate concentration (HP:0012599)2.31981642
49Large earlobe (HP:0009748)2.27237064
50Prominent supraorbital ridges (HP:0000336)2.25802020
51Thick eyebrow (HP:0000574)2.25322526
52Ureteral obstruction (HP:0006000)2.24687379
53Decreased muscle mass (HP:0003199)2.19757516
54Striae distensae (HP:0001065)2.19462322
55Renal tubular dysfunction (HP:0000124)2.16363258
56Personality changes (HP:0000751)2.15827397
57Agammaglobulinemia (HP:0004432)2.09665183
58Congenital stationary night blindness (HP:0007642)2.04157858
59Prolonged bleeding time (HP:0003010)2.03343765
60Amelogenesis imperfecta (HP:0000705)10.6454501
61Overgrowth (HP:0001548)10.6138019
62Hepatitis (HP:0012115)1.98442697
63Menorrhagia (HP:0000132)1.95573535
64Sudden cardiac death (HP:0001645)1.93764274
65Gingival overgrowth (HP:0000212)1.93693350
66Breast hypoplasia (HP:0003187)1.92649590
67Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.91646445
68Short 5th finger (HP:0009237)1.91178253
69Stage 5 chronic kidney disease (HP:0003774)1.90473440
70Ectopic kidney (HP:0000086)1.90169571
71Bronchitis (HP:0012387)1.86605166
72Torticollis (HP:0000473)1.86037594
73Epistaxis (HP:0000421)1.85388470
74Recurrent otitis media (HP:0000403)1.83150972
75Chorioretinal coloboma (HP:0000567)1.80772276
76Encephalitis (HP:0002383)1.78527194
77Hypercalciuria (HP:0002150)1.78222952
78Colitis (HP:0002583)1.77533934
79Poor speech (HP:0002465)1.70462672
80Abnormality of salivation (HP:0100755)1.66330400
81Polyneuropathy (HP:0001271)1.62468179
82Bronchiectasis (HP:0002110)1.60355758
83Small hand (HP:0200055)1.59678013
84Abnormality of Sharpey fibers (HP:0100685)1.59160042
85Delayed eruption of teeth (HP:0000684)1.57661159
86Chondrocalcinosis (HP:0000934)1.57002248
87Truncal ataxia (HP:0002078)1.56438985
88Periauricular skin pits (HP:0100277)1.55650014
89Preauricular pit (HP:0004467)1.55650014
90Decreased central vision (HP:0007663)1.52042707
91Oculomotor apraxia (HP:0000657)1.49843237
92Hyperlipoproteinemia (HP:0010980)1.49621406
93Anal stenosis (HP:0002025)1.49619230
94Ectropion (HP:0000656)1.48670380
95Blepharitis (HP:0000498)1.48513868
96Increased mean platelet volume (HP:0011877)1.43647701
97Craniofacial dystonia (HP:0012179)1.43414891
98Osteoarthritis (HP:0002758)1.42991310
99Increased density of long bones (HP:0006392)1.42480956
100Palmoplantar keratoderma (HP:0000982)1.42084477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.05411498
2BLK4.32147133
3STK33.89230392
4RIPK43.45373889
5NTRK212.9890616
6BMPR21.93202356
7CDC42BPA1.79908981
8TXK1.73919945
9ACVR1B1.22056476
10ADRBK21.14649234
11ZAK1.06593295
12ERBB41.05517759
13GRK11.04807765
14DAPK21.02080749
15SYK0.98064632
16BMPR1B0.97631739
17HIPK20.88932532
18FGFR10.88337921
19TAOK30.70962957
20CAMKK20.70094661
21PRKCQ0.68212202
22GRK70.66618851
23INSRR0.65429907
24MATK0.64270657
25MAPK150.61404364
26TLK10.61269313
27CAMKK10.61129741
28CASK0.60128402
29SRC0.59302970
30ROCK20.58013262
31PIK3CA0.57692151
32OBSCN0.56507124
33NME10.53839609
34TNIK0.53751704
35TGFBR10.53641692
36ADRBK10.52692471
37ROCK10.52372540
38CAMK2A0.51450237
39MST40.50621675
40PRKACG0.49968460
41BMX0.49350092
42WNK30.49016078
43TEC0.47461798
44PIK3CG0.47115959
45MUSK0.45495388
46MAP2K60.45473533
47PKN10.44402512
48PRKAA10.43933249
49MAP4K20.43369696
50LYN0.42818577
51BTK0.42797752
52PRKACA0.42715664
53ITK0.42585872
54GRK50.42354161
55PTK2B0.41940459
56ABL10.40182073
57TIE10.39715758
58PRKACB0.33996432
59MYLK0.33817469
60MAPK130.33242841
61PHKG20.32422562
62PHKG10.32422562
63ERBB20.31525469
64PLK40.30265722
65TNK20.29679688
66KIT0.29205265
67PLK10.28892718
68PRKCA0.28206589
69WNK40.27675432
70KDR0.27430997
71PINK10.26996036
72PAK30.26059471
73IKBKB0.25619797
74PRKCB0.25475547
75LMTK20.24474356
76FYN0.23932359
77EPHB20.22650953
78PRKCD0.22232510
79VRK10.21242077
80CSF1R0.20439767
81GRK60.19578981
82LCK0.18856297
83PRKCG0.18833435
84NTRK10.18753473
85STK390.18376128
86SRPK10.17756388
87FRK0.16772982
88MAPK140.16600613
89CSNK1A10.16444821
90TTK0.16236960
91RPS6KA30.16151151
92CHUK0.15806342
93CDK30.15221307
94CAMK10.14107278
95PRKCE0.13767385
96OXSR10.12699409
97GSK3B0.12382141
98IGF1R0.12315171
99PLK20.11491441
100INSR0.10948323

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.13057886
2Sulfur relay system_Homo sapiens_hsa041223.62745392
3Sulfur metabolism_Homo sapiens_hsa009203.47355540
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.28194447
5Ovarian steroidogenesis_Homo sapiens_hsa049133.18804350
6Linoleic acid metabolism_Homo sapiens_hsa005913.01573442
7Collecting duct acid secretion_Homo sapiens_hsa049662.89868035
8Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.51589933
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.44613789
10Bile secretion_Homo sapiens_hsa049762.34369502
11Pancreatic secretion_Homo sapiens_hsa049722.20706318
12Vibrio cholerae infection_Homo sapiens_hsa051102.17152878
13Fat digestion and absorption_Homo sapiens_hsa049752.11131133
14Salivary secretion_Homo sapiens_hsa049702.06299917
15Gastric acid secretion_Homo sapiens_hsa049712.06237911
16Thyroid hormone synthesis_Homo sapiens_hsa049182.02128997
17Circadian entrainment_Homo sapiens_hsa047131.93010705
18Synaptic vesicle cycle_Homo sapiens_hsa047211.90784358
19GABAergic synapse_Homo sapiens_hsa047271.87151286
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.83377341
21Morphine addiction_Homo sapiens_hsa050321.83252017
22Cocaine addiction_Homo sapiens_hsa050301.82137316
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76898907
24Glutamatergic synapse_Homo sapiens_hsa047241.73926931
25Taste transduction_Homo sapiens_hsa047421.70587368
26Insulin secretion_Homo sapiens_hsa049111.66928310
27Ether lipid metabolism_Homo sapiens_hsa005651.64449511
28Gap junction_Homo sapiens_hsa045401.58940011
29Arachidonic acid metabolism_Homo sapiens_hsa005901.51081861
30Dilated cardiomyopathy_Homo sapiens_hsa054141.48979843
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47456128
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47102885
33Platelet activation_Homo sapiens_hsa046111.46570606
34Amphetamine addiction_Homo sapiens_hsa050311.37279456
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36227893
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28580407
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22883273
38Calcium signaling pathway_Homo sapiens_hsa040201.21517786
39Oxytocin signaling pathway_Homo sapiens_hsa049211.14234333
40GnRH signaling pathway_Homo sapiens_hsa049121.13465010
41Cholinergic synapse_Homo sapiens_hsa047251.11709450
42Melanogenesis_Homo sapiens_hsa049161.10308880
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06529273
44Dorso-ventral axis formation_Homo sapiens_hsa043200.99679922
45Serotonergic synapse_Homo sapiens_hsa047260.99322855
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90454915
47ECM-receptor interaction_Homo sapiens_hsa045120.90022177
48Estrogen signaling pathway_Homo sapiens_hsa049150.86725517
49Circadian rhythm_Homo sapiens_hsa047100.83986852
50Rheumatoid arthritis_Homo sapiens_hsa053230.82449228
51Chemokine signaling pathway_Homo sapiens_hsa040620.81306889
52Parkinsons disease_Homo sapiens_hsa050120.77255014
53Oxidative phosphorylation_Homo sapiens_hsa001900.70245884
54Pyruvate metabolism_Homo sapiens_hsa006200.68756472
55Oocyte meiosis_Homo sapiens_hsa041140.65665164
56Primary immunodeficiency_Homo sapiens_hsa053400.63215112
57Nitrogen metabolism_Homo sapiens_hsa009100.61440524
58RNA degradation_Homo sapiens_hsa030180.61048480
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53420369
60Alcoholism_Homo sapiens_hsa050340.53138698
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51293557
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.42966792
63Hematopoietic cell lineage_Homo sapiens_hsa046400.41989644
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40868595
65cAMP signaling pathway_Homo sapiens_hsa040240.40744351
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38776218
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.38068554
68Retinol metabolism_Homo sapiens_hsa008300.34032081
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33653372
70Dopaminergic synapse_Homo sapiens_hsa047280.33510512
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.33120487
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31700198
73ABC transporters_Homo sapiens_hsa020100.31298474
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31189483
75Systemic lupus erythematosus_Homo sapiens_hsa053220.30852845
76Purine metabolism_Homo sapiens_hsa002300.30100956
77Phototransduction_Homo sapiens_hsa047440.29779386
78Staphylococcus aureus infection_Homo sapiens_hsa051500.29189776
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25144185
80Chemical carcinogenesis_Homo sapiens_hsa052040.23700949
81Hedgehog signaling pathway_Homo sapiens_hsa043400.18955697
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18552279
83Autoimmune thyroid disease_Homo sapiens_hsa053200.18265201
84Nicotine addiction_Homo sapiens_hsa050330.17655475
85Phagosome_Homo sapiens_hsa041450.15086094
86Graft-versus-host disease_Homo sapiens_hsa053320.14259105
87Rap1 signaling pathway_Homo sapiens_hsa040150.14040630
88Ras signaling pathway_Homo sapiens_hsa040140.12625985
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12007247
90Fatty acid biosynthesis_Homo sapiens_hsa000610.11892665
91Type I diabetes mellitus_Homo sapiens_hsa049400.11890646
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.11852002
93Asthma_Homo sapiens_hsa053100.11766898
94Prion diseases_Homo sapiens_hsa050200.11273222
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.09176384
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.07768567
97African trypanosomiasis_Homo sapiens_hsa051430.07063572
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05002172
99Caffeine metabolism_Homo sapiens_hsa002320.03405083
100Allograft rejection_Homo sapiens_hsa053300.03000360

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