OR7E111P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)9.69978676
2regulation of T-helper 2 cell differentiation (GO:0045628)9.51520726
3activation of protein kinase A activity (GO:0034199)9.41644465
4negative regulation of type 2 immune response (GO:0002829)9.31299673
5seminiferous tubule development (GO:0072520)9.04102233
6positive regulation of RNA splicing (GO:0033120)8.85885563
7negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.46335477
8detection of chemical stimulus involved in sensory perception (GO:0050907)8.40536156
9cAMP biosynthetic process (GO:0006171)8.17799295
10negative regulation of cytosolic calcium ion concentration (GO:0051481)8.02606877
11negative regulation of alpha-beta T cell differentiation (GO:0046639)7.70340785
12enteric nervous system development (GO:0048484)7.38571933
13regulation of protein sumoylation (GO:0033233)6.88608290
14righting reflex (GO:0060013)6.56437892
15positive regulation of T-helper 1 type immune response (GO:0002827)6.56013340
16dendritic spine morphogenesis (GO:0060997)6.55157237
17synaptic transmission, dopaminergic (GO:0001963)6.47466000
18positive regulation of mitochondrial fission (GO:0090141)6.22356707
19detection of chemical stimulus (GO:0009593)6.14997650
20positive regulation of T-helper cell differentiation (GO:0045624)6.03723513
21heterotypic cell-cell adhesion (GO:0034113)6.00542866
22hepatocyte apoptotic process (GO:0097284)5.74287049
23icosanoid secretion (GO:0032309)5.63630701
24arachidonic acid secretion (GO:0050482)5.63630701
25phosphatidylinositol acyl-chain remodeling (GO:0036149)5.57035692
26endothelial cell differentiation (GO:0045446)5.39323379
27regulation of cAMP-mediated signaling (GO:0043949)5.33827922
28phosphatidylserine acyl-chain remodeling (GO:0036150)5.00664474
29drug transmembrane transport (GO:0006855)4.96368600
30phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.92638565
31neuronal ion channel clustering (GO:0045161)4.72399287
32regulation of T-helper 1 type immune response (GO:0002825)4.70087856
33icosanoid transport (GO:0071715)4.64905627
34fatty acid derivative transport (GO:1901571)4.64905627
35positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.60132204
36cilium or flagellum-dependent cell motility (GO:0001539)4.59226143
37regulation of mitochondrial fission (GO:0090140)4.58534886
38neural tube formation (GO:0001841)4.57145697
39nephron epithelium morphogenesis (GO:0072088)4.49699379
40nephron tubule morphogenesis (GO:0072078)4.49699379
41negative regulation of alpha-beta T cell activation (GO:0046636)4.48567230
42hyaluronan catabolic process (GO:0030214)4.46003882
43protein localization to synapse (GO:0035418)4.43489060
44regulation of T-helper cell differentiation (GO:0045622)4.35890640
45chemosensory behavior (GO:0007635)4.31559294
46vocalization behavior (GO:0071625)4.12845758
47embryonic digestive tract morphogenesis (GO:0048557)4.06383473
48cyclic purine nucleotide metabolic process (GO:0052652)4.03876257
49response to dietary excess (GO:0002021)4.02629353
50positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.02376452
51cAMP metabolic process (GO:0046058)3.98802793
52cellular response to ATP (GO:0071318)3.97755387
53retina layer formation (GO:0010842)3.96447404
54left/right axis specification (GO:0070986)3.94780364
55cyclic nucleotide biosynthetic process (GO:0009190)3.90019334
56attachment of spindle microtubules to kinetochore (GO:0008608)3.89475180
57negative regulation of actin filament bundle assembly (GO:0032232)3.88703172
58positive regulation of membrane potential (GO:0045838)3.87475396
59cellular response to glucagon stimulus (GO:0071377)3.86045642
60regulation of type 2 immune response (GO:0002828)3.84477261
61water transport (GO:0006833)3.79716282
62energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.77394743
63ATP hydrolysis coupled proton transport (GO:0015991)3.77394743
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.71088409
65dendritic spine organization (GO:0097061)3.67486408
66monoamine transport (GO:0015844)3.65059819
67positive regulation of cAMP-mediated signaling (GO:0043950)3.61845760
68phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.52926781
69adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.52652218
70mitochondrial fusion (GO:0008053)3.51694139
71leukotriene biosynthetic process (GO:0019370)3.50927815
72regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.42882728
73adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.39644452
74sulfur amino acid catabolic process (GO:0000098)3.38574672
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.37830001
76fluid transport (GO:0042044)3.37167721
77drug transport (GO:0015893)3.36170994
78negative regulation of T cell differentiation (GO:0045581)3.36011549
79regulation of glutamate receptor signaling pathway (GO:1900449)3.33105068
80positive regulation of alpha-beta T cell differentiation (GO:0046638)3.32755186
81cellular zinc ion homeostasis (GO:0006882)3.32649253
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32199467
83negative regulation of cAMP-mediated signaling (GO:0043951)3.29888121
84opioid receptor signaling pathway (GO:0038003)3.29490932
85positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.21999278
86renal tubule morphogenesis (GO:0061333)3.17079689
87adult feeding behavior (GO:0008343)3.15639912
88positive regulation of steroid hormone secretion (GO:2000833)3.12342876
89reflex (GO:0060004)3.09708078
90positive regulation of protein targeting to membrane (GO:0090314)3.07579713
91behavioral response to ethanol (GO:0048149)3.05139008
92neurofilament cytoskeleton organization (GO:0060052)3.03269063
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02918475
94negative regulation of astrocyte differentiation (GO:0048712)3.02863297
95detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.5645872
96tooth mineralization (GO:0034505)13.4018384
97positive regulation of protein sumoylation (GO:0033235)11.0424202
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)10.5641341
99negative regulation of T-helper cell differentiation (GO:0045623)10.5641341
100protein K11-linked deubiquitination (GO:0035871)10.1574998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.00981094
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.69536208
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.25260237
4IGF1R_20145208_ChIP-Seq_DFB_Human4.48340686
5VDR_22108803_ChIP-Seq_LS180_Human4.46946725
6AR_21572438_ChIP-Seq_LNCaP_Human4.36570948
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.11259979
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40579431
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.40579431
10TP53_16413492_ChIP-PET_HCT116_Human2.12956824
11PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.12748434
12EGR1_19032775_ChIP-ChIP_M12_Human1.95571822
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93481913
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85868457
15DROSHA_22980978_ChIP-Seq_HELA_Human1.79526025
16RXR_22108803_ChIP-Seq_LS180_Human1.76408378
17YY1_22570637_ChIP-Seq_MALME-3M_Human1.75219398
18GATA1_19941826_ChIP-Seq_K562_Human1.69365646
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68662680
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59673652
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.57744363
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55216565
23NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54247261
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.49018776
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.45216737
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45020713
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.43761415
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41418536
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38210033
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37905277
31GBX2_23144817_ChIP-Seq_PC3_Human1.35924759
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34577279
33RNF2_27304074_Chip-Seq_NSC_Mouse1.33096458
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.29903192
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.24790320
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.20136256
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15146341
38BCAT_22108803_ChIP-Seq_LS180_Human1.14578770
39TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14401000
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14223293
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13739831
42TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13012420
43KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11900035
44STAT3_23295773_ChIP-Seq_U87_Human1.11656911
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.11065879
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.09690155
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09277959
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08699772
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07561633
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06933924
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06925833
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06872242
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06791930
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.05987647
55ER_23166858_ChIP-Seq_MCF-7_Human1.05335729
56EZH2_22144423_ChIP-Seq_EOC_Human1.03863961
57ZNF274_21170338_ChIP-Seq_K562_Hela1.03525501
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.03096249
59SMAD4_21741376_ChIP-Seq_HESCs_Human1.02758377
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02731844
61CBP_20019798_ChIP-Seq_JUKART_Human1.02731844
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02621646
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02243069
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.01806218
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01166666
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99428739
67ARNT_22903824_ChIP-Seq_MCF-7_Human0.98288096
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97227580
69EZH2_27294783_Chip-Seq_NPCs_Mouse0.97159345
70HTT_18923047_ChIP-ChIP_STHdh_Human0.97023647
71NANOG_20526341_ChIP-Seq_ESCs_Human0.96888280
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95326497
73HNFA_21074721_ChIP-Seq_CACO-2_Human0.94672095
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93998048
75BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93815979
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93391358
77CJUN_26792858_Chip-Seq_BT549_Human0.92875780
78DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92508432
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90879129
80CMYC_18555785_Chip-Seq_ESCs_Mouse0.90597434
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89916151
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89790651
83TBL1_22424771_ChIP-Seq_293T_Human0.89776753
84REST_21632747_ChIP-Seq_MESCs_Mouse0.89757856
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89459131
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.88391635
87SMAD4_21799915_ChIP-Seq_A2780_Human0.85199271
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83926230
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83565651
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.83358536
91EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83176712
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83176712
93SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83101619
94PHF8_20622853_ChIP-Seq_HELA_Human0.83057556
95TP53_18474530_ChIP-ChIP_U2OS_Human0.83054849
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.82967587
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82522780
98AR_25329375_ChIP-Seq_VCAP_Human0.80129994
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80047250
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.79619386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.19064569
2MP0004130_abnormal_muscle_cell5.03413152
3MP0004264_abnormal_extraembryonic_tissu4.04329184
4MP0003252_abnormal_bile_duct3.40359586
5MP0002928_abnormal_bile_duct2.55539975
6MP0004133_heterotaxia2.43221988
7MP0006072_abnormal_retinal_apoptosis2.41527313
8MP0001270_distended_abdomen2.34151564
9MP0009764_decreased_sensitivity_to2.24384559
10MP0005448_abnormal_energy_balance2.15830582
11MP0005084_abnormal_gallbladder_morpholo11.8005589
12MP0005408_hypopigmentation1.97514529
13MP0002751_abnormal_autonomic_nervous1.93319952
14MP0003329_amyloid_beta_deposits1.79215924
15MP0009278_abnormal_bone_marrow1.76623338
16MP0004272_abnormal_basement_membrane1.75982039
17MP0005646_abnormal_pituitary_gland1.71456800
18MP0002876_abnormal_thyroid_physiology1.63566700
19MP0003943_abnormal_hepatobiliary_system1.58678047
20MP0009780_abnormal_chondrocyte_physiolo1.56100703
21MP0005503_abnormal_tendon_morphology1.54568137
22MP0005360_urolithiasis1.43974742
23MP0005220_abnormal_exocrine_pancreas1.40014948
24MP0005165_increased_susceptibility_to1.38714632
25MP0003638_abnormal_response/metabolism_1.37249414
26MP0005379_endocrine/exocrine_gland_phen1.29353135
27MP0001968_abnormal_touch/_nociception1.28215477
28MP0001958_emphysema1.22611827
29MP0003718_maternal_effect1.15710326
30MP0001529_abnormal_vocalization1.14625516
31MP0003880_abnormal_central_pattern1.12001922
32MP0000678_abnormal_parathyroid_gland1.11399039
33MP0000604_amyloidosis1.06436061
34MP0001501_abnormal_sleep_pattern1.05756390
35MP0002572_abnormal_emotion/affect_behav1.04321328
36MP0001944_abnormal_pancreas_morphology1.01328945
37MP0005551_abnormal_eye_electrophysiolog0.98676519
38MP0000470_abnormal_stomach_morphology0.98149801
39MP0002693_abnormal_pancreas_physiology0.93507891
40MP0001905_abnormal_dopamine_level0.88348559
41MP0003941_abnormal_skin_development0.85949086
42MP0003195_calcinosis0.81467067
43MP0002909_abnormal_adrenal_gland0.80566219
44MP0002249_abnormal_larynx_morphology0.71479735
45MP0000681_abnormal_thyroid_gland0.70919775
46MP0008569_lethality_at_weaning0.69917863
47MP0008875_abnormal_xenobiotic_pharmacok0.69701537
48MP0000465_gastrointestinal_hemorrhage0.69591174
49MP0002078_abnormal_glucose_homeostasis0.69113177
50MP0001533_abnormal_skeleton_physiology0.69007365
51MP0005164_abnormal_response_to0.68720976
52MP0003953_abnormal_hormone_level0.68114597
53MP0002998_abnormal_bone_remodeling0.66727527
54MP0002098_abnormal_vibrissa_morphology0.65631157
55MP0001664_abnormal_digestion0.65327400
56MP0001851_eye_inflammation0.63524961
57MP0005253_abnormal_eye_physiology0.62968239
58MP0001915_intracranial_hemorrhage0.62829351
59MP0008469_abnormal_protein_level0.62556189
60MP0005334_abnormal_fat_pad0.62184367
61MP0001800_abnormal_humoral_immune0.60655202
62MP0002136_abnormal_kidney_physiology0.60376838
63MP0003121_genomic_imprinting0.60122572
64MP0004019_abnormal_vitamin_homeostasis0.59484188
65MP0002405_respiratory_system_inflammati0.59249494
66MP0005645_abnormal_hypothalamus_physiol0.58513240
67MP0003866_abnormal_defecation0.58477111
68MP0000703_abnormal_thymus_morphology0.57077178
69MP0000609_abnormal_liver_physiology0.56235432
70MP0003879_abnormal_hair_cell0.55958849
71MP0005387_immune_system_phenotype0.55265603
72MP0001790_abnormal_immune_system0.55265603
73MP0000371_diluted_coat_color0.54109490
74MP0002229_neurodegeneration0.47744852
75MP0003633_abnormal_nervous_system0.46469620
76MP0009642_abnormal_blood_homeostasis0.44839932
77MP0000920_abnormal_myelination0.44085811
78MP0005390_skeleton_phenotype0.43920449
79MP0004947_skin_inflammation0.42173396
80MP0001845_abnormal_inflammatory_respons0.40460519
81MP0005395_other_phenotype0.39154327
82MP0009333_abnormal_splenocyte_physiolog0.37962601
83MP0009053_abnormal_anal_canal0.36614001
84MP0003045_fibrosis0.36320986
85MP0005397_hematopoietic_system_phenotyp0.35899467
86MP0001545_abnormal_hematopoietic_system0.35899467
87MP0002882_abnormal_neuron_morphology0.35529732
88MP0005195_abnormal_posterior_eye0.34593851
89MP0000759_abnormal_skeletal_muscle0.33751246
90MP0004484_altered_response_of0.33048955
91MP0003631_nervous_system_phenotype0.32942958
92MP0002733_abnormal_thermal_nociception0.32545147
93MP0001986_abnormal_taste_sensitivity0.31478717
94MP0001299_abnormal_eye_distance/0.30650825
95MP0003635_abnormal_synaptic_transmissio0.30216081
96MP0002063_abnormal_learning/memory/cond0.29438136
97MP0002419_abnormal_innate_immunity0.28215789
98MP0001970_abnormal_pain_threshold0.27797096
99MP0002722_abnormal_immune_system0.27267440
100MP0002429_abnormal_blood_cell0.26856910

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)8.91092147
2Abnormality of dental color (HP:0011073)7.78670662
3Osteomalacia (HP:0002749)7.25624715
4Polyuria (HP:0000103)7.19024508
5Volvulus (HP:0002580)7.05937772
6Abnormality of renal resorption (HP:0011038)7.00883833
7Abnormality of the dental pulp (HP:0006479)6.76875901
8Abnormal urine output (HP:0012590)6.14071550
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.10396298
10Thyroid-stimulating hormone excess (HP:0002925)6.06306789
11Abnormality of renal excretion (HP:0011036)5.32610965
12Round ear (HP:0100830)5.00600700
13Chronic bronchitis (HP:0004469)4.46654009
14Autoimmune thrombocytopenia (HP:0001973)3.85705978
15Lip pit (HP:0100267)3.68480908
16Toxemia of pregnancy (HP:0100603)3.68296075
17Molar tooth sign on MRI (HP:0002419)3.58729194
18Abnormality of midbrain morphology (HP:0002418)3.58729194
19IgM deficiency (HP:0002850)3.41849071
20Nephrocalcinosis (HP:0000121)3.41835416
21Depressed nasal tip (HP:0000437)3.41149495
22Esophageal varix (HP:0002040)3.16458409
23Intestinal atresia (HP:0011100)3.11763723
24Large earlobe (HP:0009748)3.05215343
25Rhinitis (HP:0012384)3.04688849
26Striae distensae (HP:0001065)3.02544297
27Abnormal respiratory motile cilium physiology (HP:0012261)2.99727854
28Tachypnea (HP:0002789)2.98818480
29Lipoatrophy (HP:0100578)2.85211293
30Drooling (HP:0002307)2.81351793
31Sparse lateral eyebrow (HP:0005338)2.77059863
32Excessive salivation (HP:0003781)2.68829195
33Thick eyebrow (HP:0000574)2.65212682
34Pancreatic islet-cell hyperplasia (HP:0004510)2.58408405
35Hypoparathyroidism (HP:0000829)2.54138388
36Ectropion (HP:0000656)2.45900400
37Intestinal fistula (HP:0100819)2.42882158
38Inability to walk (HP:0002540)2.39996892
39Panhypogammaglobulinemia (HP:0003139)2.39768445
40Nephronophthisis (HP:0000090)2.38415449
41Abnormality of the aortic arch (HP:0012303)2.37861603
42Hyperphosphaturia (HP:0003109)2.36487348
43Truncal ataxia (HP:0002078)2.30385732
44Broad alveolar ridges (HP:0000187)2.25825846
45Personality changes (HP:0000751)2.24544806
46Focal motor seizures (HP:0011153)2.22744712
47Poor speech (HP:0002465)2.15120226
48Sudden cardiac death (HP:0001645)2.15001419
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.12207789
50Oligodontia (HP:0000677)2.10813212
51Short 5th finger (HP:0009237)2.08729797
52Abnormality of transition element cation homeostasis (HP:0011030)2.08139456
53Abnormality of urine glucose concentration (HP:0011016)2.05641700
54Glycosuria (HP:0003076)2.05641700
55Petechiae (HP:0000967)2.04417400
56Hypercalciuria (HP:0002150)2.04347726
57Ureteral stenosis (HP:0000071)2.03398783
58Abnormal urine phosphate concentration (HP:0012599)2.01123193
59Nephropathy (HP:0000112)2.00254103
60Amelogenesis imperfecta (HP:0000705)11.3054090
61Overgrowth (HP:0001548)10.8115853
62Dilated cardiomyopathy (HP:0001644)1.99437769
63Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.98279373
64Abnormality of the fingertips (HP:0001211)1.96950791
65Hepatitis (HP:0012115)1.94745488
66Mesangial abnormality (HP:0001966)1.94295823
67Abnormality of salivation (HP:0100755)1.93869877
68Gingival overgrowth (HP:0000212)1.90371273
69Thickened helices (HP:0000391)1.90100829
70Large for gestational age (HP:0001520)1.89340905
71Abnormality of the renal medulla (HP:0100957)1.89020651
72Chronic mucocutaneous candidiasis (HP:0002728)1.87666622
73Recurrent cutaneous fungal infections (HP:0011370)1.87666622
74Ureteral obstruction (HP:0006000)1.85659322
75Preauricular pit (HP:0004467)1.82370299
76Periauricular skin pits (HP:0100277)1.82370299
77Decreased muscle mass (HP:0003199)1.81412841
78Congenital ichthyosiform erythroderma (HP:0007431)1.80295202
79Recurrent otitis media (HP:0000403)1.79590075
80Abnormality of endocrine pancreas physiology (HP:0012093)1.79383778
81Abnormality of the pancreatic islet cells (HP:0006476)1.79383778
82Colitis (HP:0002583)1.78841973
83Bronchitis (HP:0012387)1.76370232
84Chorioretinal coloboma (HP:0000567)1.73326258
85Delayed eruption of teeth (HP:0000684)1.70813863
86Abnormality of Sharpey fibers (HP:0100685)1.69029690
87Chondrocalcinosis (HP:0000934)1.68238815
88Ectopic kidney (HP:0000086)1.65147505
89Lack of skin elasticity (HP:0100679)1.63182239
90Blepharitis (HP:0000498)1.60909157
91Myositis (HP:0100614)1.55673478
92Autoimmune hemolytic anemia (HP:0001890)1.55230624
93Agammaglobulinemia (HP:0004432)1.54396938
94Polyneuropathy (HP:0001271)1.54195890
95Prominent supraorbital ridges (HP:0000336)1.53572592
96Preauricular skin tag (HP:0000384)1.52076981
97Gastrointestinal atresia (HP:0002589)1.51920942
98Agitation (HP:0000713)1.49892287
99Anal stenosis (HP:0002025)1.48515231
100Stage 5 chronic kidney disease (HP:0003774)1.48145388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.18098997
2BLK4.03642530
3STK34.03541851
4ADRBK24.03494336
5RIPK42.81122485
6CDC42BPA2.12072716
7NTRK213.3987721
8BMPR21.77371261
9FRK1.70892203
10ERN11.33739936
11PINK11.23775690
12HIPK21.01101024
13ADRBK11.00908402
14IRAK30.93805934
15FGFR10.85520752
16PRKCG0.68398574
17MUSK0.68393596
18GRK10.67067020
19WNK30.62982761
20GRK70.62594124
21SYK0.60005382
22ROCK20.58973745
23PRKAA10.58581341
24CAMK2A0.56838805
25OBSCN0.56116729
26PRKCE0.55875317
27SRC0.55240202
28INSRR0.53674268
29ABL10.49438297
30PRKCQ0.48743348
31PRKACG0.47474502
32TGFBR10.43889997
33TXK0.43330075
34IRAK10.42042097
35TIE10.41231769
36ROCK10.39775276
37MAP4K20.39227576
38PRKACA0.37781660
39PIK3CG0.34478475
40MAPK150.34338172
41PRKACB0.33732458
42PRKCB0.31778983
43ACVR1B0.31411206
44PRKCA0.30905548
45PNCK0.30229562
46GRK50.29273597
47RIPK10.28537282
48TYRO30.28361644
49RPS6KA30.27979522
50PHKG20.26837142
51PHKG10.26837142
52GSK3B0.25699305
53OXSR10.23271734
54MAPK140.22622764
55MAPK110.20097699
56ERBB40.19540541
57BMPR1B0.18525306
58CSNK1A10.18461814
59TEC0.18428111
60SGK10.17448832
61PRKCI0.16971470
62EPHA40.16753603
63ERBB20.16515992
64PLK20.15073708
65CDK10.14594416
66AKT10.14232053
67MATK0.14070188
68DYRK30.14026446
69MAPKAPK50.13741060
70PKN10.13533448
71LYN0.13319420
72FLT30.13229113
73MARK10.13209250
74KIT0.13185146
75PLK10.13128680
76TGFBR20.13041960
77MOS0.12534531
78FYN0.12390164
79ITK0.12177068
80PRKDC0.11960002
81CLK10.11729491
82MST1R0.11260818
83STK390.11032724
84CHUK0.09381568
85PRKCD0.08771765
86LMTK20.08656527
87NTRK30.08179191
88CAMK10.08005673
89IGF1R0.07817457
90MAPK90.07530410
91LCK0.07070120
92CASK0.06919380
93PLK40.06378304
94TLK10.06218586
95WNK40.05896940
96TTN0.05871577
97DDR20.05357631
98MAP2K60.05150877
99EPHA20.05109456
100ZAK0.04361317

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.59559207
2Sulfur relay system_Homo sapiens_hsa041223.86685910
3Ovarian steroidogenesis_Homo sapiens_hsa049133.52389218
4Sulfur metabolism_Homo sapiens_hsa009203.29288762
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18989329
6Linoleic acid metabolism_Homo sapiens_hsa005912.99186853
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.68589346
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.59516535
9Bile secretion_Homo sapiens_hsa049762.26360380
10Collecting duct acid secretion_Homo sapiens_hsa049662.21502776
11Pancreatic secretion_Homo sapiens_hsa049722.18198294
12Salivary secretion_Homo sapiens_hsa049702.14600761
13Morphine addiction_Homo sapiens_hsa050322.07749895
14Thyroid hormone synthesis_Homo sapiens_hsa049182.05490181
15Vibrio cholerae infection_Homo sapiens_hsa051102.05156624
16Gastric acid secretion_Homo sapiens_hsa049711.95435673
17Fat digestion and absorption_Homo sapiens_hsa049751.93845612
18Taste transduction_Homo sapiens_hsa047421.90329255
19Circadian entrainment_Homo sapiens_hsa047131.85704202
20Synaptic vesicle cycle_Homo sapiens_hsa047211.78069203
21Dorso-ventral axis formation_Homo sapiens_hsa043201.77993831
22Glutamatergic synapse_Homo sapiens_hsa047241.76023057
23Insulin secretion_Homo sapiens_hsa049111.75617239
24Cocaine addiction_Homo sapiens_hsa050301.74736939
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.74154025
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71142904
27GABAergic synapse_Homo sapiens_hsa047271.63366755
28Ether lipid metabolism_Homo sapiens_hsa005651.61657853
29Dilated cardiomyopathy_Homo sapiens_hsa054141.60836843
30Arachidonic acid metabolism_Homo sapiens_hsa005901.50850487
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50711750
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.46025010
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42315359
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38734840
35Gap junction_Homo sapiens_hsa045401.38733991
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31174205
37GnRH signaling pathway_Homo sapiens_hsa049121.27561649
38Amphetamine addiction_Homo sapiens_hsa050311.26527387
39Estrogen signaling pathway_Homo sapiens_hsa049151.26378817
40Melanogenesis_Homo sapiens_hsa049161.25574222
41Oxytocin signaling pathway_Homo sapiens_hsa049211.16610475
42Calcium signaling pathway_Homo sapiens_hsa040201.13593560
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10554682
44Platelet activation_Homo sapiens_hsa046111.09952926
45Cholinergic synapse_Homo sapiens_hsa047251.08151142
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98889464
47ECM-receptor interaction_Homo sapiens_hsa045120.81128590
48Serotonergic synapse_Homo sapiens_hsa047260.81023237
49Circadian rhythm_Homo sapiens_hsa047100.78136753
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.76524213
51Pyruvate metabolism_Homo sapiens_hsa006200.68311147
52Chemokine signaling pathway_Homo sapiens_hsa040620.61987991
53Rheumatoid arthritis_Homo sapiens_hsa053230.61024548
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56635135
55Oocyte meiosis_Homo sapiens_hsa041140.54968554
56RNA degradation_Homo sapiens_hsa030180.53841542
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45948576
58cAMP signaling pathway_Homo sapiens_hsa040240.45446552
59ABC transporters_Homo sapiens_hsa020100.42735538
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.42339764
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41047795
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39065735
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.38318125
64Retinol metabolism_Homo sapiens_hsa008300.37880357
65Staphylococcus aureus infection_Homo sapiens_hsa051500.33056829
66Phototransduction_Homo sapiens_hsa047440.32224936
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30004355
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.28451626
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.28261351
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26486202
71Alcoholism_Homo sapiens_hsa050340.26399301
72Hedgehog signaling pathway_Homo sapiens_hsa043400.26114693
73Complement and coagulation cascades_Homo sapiens_hsa046100.25945418
74Purine metabolism_Homo sapiens_hsa002300.25801855
75Dopaminergic synapse_Homo sapiens_hsa047280.25647649
76Primary immunodeficiency_Homo sapiens_hsa053400.24373848
77Caffeine metabolism_Homo sapiens_hsa002320.22814240
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22304842
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22122829
80Prion diseases_Homo sapiens_hsa050200.21532359
81Glucagon signaling pathway_Homo sapiens_hsa049220.19663383
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16710122
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.13937236
84Rap1 signaling pathway_Homo sapiens_hsa040150.13935617
85Chemical carcinogenesis_Homo sapiens_hsa052040.13848327
86Nicotine addiction_Homo sapiens_hsa050330.11593918
87Parkinsons disease_Homo sapiens_hsa050120.10589378
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.10293122
89Tuberculosis_Homo sapiens_hsa051520.09064095
90African trypanosomiasis_Homo sapiens_hsa051430.08187182
91Ras signaling pathway_Homo sapiens_hsa040140.07230686
92HTLV-I infection_Homo sapiens_hsa051660.06254225
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05662265
94Renin secretion_Homo sapiens_hsa049240.04313798
95Type I diabetes mellitus_Homo sapiens_hsa049400.04036437
96Starch and sucrose metabolism_Homo sapiens_hsa005000.03692487
97Systemic lupus erythematosus_Homo sapiens_hsa053220.01828671
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.01079410
99Graft-versus-host disease_Homo sapiens_hsa053320.00658339
100Phagosome_Homo sapiens_hsa041450.00351814

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