ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	auditory receptor cell differentiation (GO:0042491)	6.32011437
2	pattern specification involved in kidney development (GO:0061004)	6.12291581
3	behavioral response to nicotine (GO:0035095)	5.62913248
4	L-fucose metabolic process (GO:0042354)	5.55675432
5	L-fucose catabolic process (GO:0042355)	5.55675432
6	fucose catabolic process (GO:0019317)	5.55675432
7	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.39868598
8	base-excision repair, AP site formation (GO:0006285)	4.88848798
9	neuron fate determination (GO:0048664)	4.85711524
10	protein K11-linked deubiquitination (GO:0035871)	4.83899862
11	behavioral response to ethanol (GO:0048149)	4.81366721
12	pyrimidine nucleotide catabolic process (GO:0006244)	4.74207520
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.73432598
14	epithelial cilium movement (GO:0003351)	4.67828908
15	nephron tubule morphogenesis (GO:0072078)	4.67156397
16	nephron epithelium morphogenesis (GO:0072088)	4.67156397
17	segment specification (GO:0007379)	4.49852988
18	intraciliary transport (GO:0042073)	4.47760076
19	cilium movement (GO:0003341)	4.41773901
20	regulation of penile erection (GO:0060405)	4.32419287
21	cilium or flagellum-dependent cell motility (GO:0001539)	4.20571817
22	axon ensheathment in central nervous system (GO:0032291)	4.17044979
23	central nervous system myelination (GO:0022010)	4.17044979
24	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	4.14663042
25	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.13558727
26	renal tubule morphogenesis (GO:0061333)	4.09344630
27	axoneme assembly (GO:0035082)	3.93271944
28	neuronal stem cell maintenance (GO:0097150)	3.88495755
29	tachykinin receptor signaling pathway (GO:0007217)	3.88454406
30	deoxyribonucleotide catabolic process (GO:0009264)	3.82937724
31	radial glial cell differentiation (GO:0060019)	3.79182279
32	axonemal dynein complex assembly (GO:0070286)	3.78397138
33	negative regulation of astrocyte differentiation (GO:0048712)	3.78143384
34	inner ear receptor cell differentiation (GO:0060113)	3.74779563
35	preassembly of GPI anchor in ER membrane (GO:0016254)	3.68659391
36	astrocyte differentiation (GO:0048708)	3.57047552
37	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.53060763
38	nonmotile primary cilium assembly (GO:0035058)	3.52013355
39	dendritic spine morphogenesis (GO:0060997)	3.47262765
40	pyrimidine nucleobase catabolic process (GO:0006208)	3.41596569
41	regulation of cilium movement (GO:0003352)	3.41544628
42	gamma-aminobutyric acid transport (GO:0015812)	3.39135230
43	telencephalon development (GO:0021537)	3.35469876
44	cilium organization (GO:0044782)	3.33876754
45	deoxyribose phosphate catabolic process (GO:0046386)	3.33250686
46	presynaptic membrane assembly (GO:0097105)	3.28809515
47	cilium assembly (GO:0042384)	3.28469890
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.28398237
49	forebrain morphogenesis (GO:0048853)	3.25944693
50	protein polyglutamylation (GO:0018095)	3.25736347
51	DNA double-strand break processing (GO:0000729)	3.25575913
52	histone H3-K9 methylation (GO:0051567)	3.25256017
53	DNA damage response, detection of DNA damage (GO:0042769)	3.24482349
54	positive regulation of megakaryocyte differentiation (GO:0045654)	3.24035078
55	regulation of hematopoietic progenitor cell differentiation (GO:1901532)	3.22310452
56	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.21360830
57	neuronal action potential (GO:0019228)	3.19248927
58	regulation of sarcomere organization (GO:0060297)	3.18904772
59	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.18752545
60	Sertoli cell development (GO:0060009)	3.16954681
61	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.12000685
62	photoreceptor cell maintenance (GO:0045494)	3.11660680
63	regulation of oligodendrocyte differentiation (GO:0048713)	3.11550053
64	positive regulation of Notch signaling pathway (GO:0045747)	3.10511765
65	arginine catabolic process (GO:0006527)	3.10283756
66	regulation of feeding behavior (GO:0060259)	3.07689217
67	motile cilium assembly (GO:0044458)	3.07057869
68	retinal cone cell development (GO:0046549)	3.02452850
69	organelle disassembly (GO:1903008)	3.02057915
70	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.00747865
71	short-term memory (GO:0007614)	3.00662913
72	limb bud formation (GO:0060174)	2.99502920
73	neural tube formation (GO:0001841)	2.98270547
74	central nervous system projection neuron axonogenesis (GO:0021952)	2.97682300
75	retinal ganglion cell axon guidance (GO:0031290)	2.96582342
76	fucosylation (GO:0036065)	2.95693078
77	forebrain neuron differentiation (GO:0021879)	2.93343230
78	regulation of respiratory system process (GO:0044065)	2.92200637
79	kynurenine metabolic process (GO:0070189)	2.89527816
80	cilium morphogenesis (GO:0060271)	2.89502982
81	purine deoxyribonucleotide catabolic process (GO:0009155)	2.88839153
82	mannosylation (GO:0097502)	2.87476929
83	protein import into peroxisome matrix (GO:0016558)	2.83885018
84	neurotransmitter-gated ion channel clustering (GO:0072578)	2.81402116
85	tryptophan catabolic process (GO:0006569)	2.81000837
86	indole-containing compound catabolic process (GO:0042436)	2.81000837
87	indolalkylamine catabolic process (GO:0046218)	2.81000837
88	C-terminal protein amino acid modification (GO:0018410)	2.80968425
89	water-soluble vitamin biosynthetic process (GO:0042364)	2.80440182
90	C-terminal protein lipidation (GO:0006501)	2.78987269
91	positive regulation of interleukin-8 secretion (GO:2000484)	2.78251815
92	postsynaptic membrane organization (GO:0001941)	2.76827930
93	hair cell differentiation (GO:0035315)	2.75878098
94	2-deoxyribonucleotide metabolic process (GO:0009394)	2.75601908
95	neuronal action potential propagation (GO:0019227)	2.75125812
96	synaptic transmission, cholinergic (GO:0007271)	2.69915625
97	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.69851885
98	opioid receptor signaling pathway (GO:0038003)	2.66654416
99	nucleobase catabolic process (GO:0046113)	2.65627204
100	mechanoreceptor differentiation (GO:0042490)	2.65045652

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.03743077
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.66973659
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.56225065
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03987528
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87792381
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.84978807
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.75609315
8	VDR_22108803_ChIP-Seq_LS180_Human	2.72664903
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71984790
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57550086
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49724238
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.37303595
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27656342
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19137882
15	REST_21632747_ChIP-Seq_MESCs_Mouse	2.18340525
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08205977
17	FUS_26573619_Chip-Seq_HEK293_Human	2.05792037
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04924392
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.98706263
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.98706263
21	RNF2_27304074_Chip-Seq_NSC_Mouse	1.95988036
22	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.93476981
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.92750332
24	P300_19829295_ChIP-Seq_ESCs_Human	1.85643301
25	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.81517326
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.81502338
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.72959327
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.71618081
29	EWS_26573619_Chip-Seq_HEK293_Human	1.63696120
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63609739
31	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.59867942
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59306702
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52550065
34	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.51418899
35	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50304607
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50236817
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49874600
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49736907
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49674281
40	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45978006
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.45704917
42	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45355224
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43548705
44	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.40840789
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.40686656
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.39899836
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39320243
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.36485572
49	AR_25329375_ChIP-Seq_VCAP_Human	1.35482212
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34114413
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33867562
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33637170
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33253083
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32231662
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32231662
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31619461
57	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.30931339
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28909629
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.28896168
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.26358939
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.25368221
62	STAT3_23295773_ChIP-Seq_U87_Human	1.24999179
63	DROSHA_22980978_ChIP-Seq_HELA_Human	1.24560579
64	TCF4_23295773_ChIP-Seq_U87_Human	1.22984792
65	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.22190679
66	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.21685396
67	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21284897
68	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.19673367
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.19319218
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18244167
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17916562
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15174063
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14321850
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13959306
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12952377
76	NCOR_22424771_ChIP-Seq_293T_Human	1.11490348
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.11064372
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09698440
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09479304
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08964975
81	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08877127
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08486509
83	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08309765
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08213921
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07725023
86	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.07583865
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.06131473
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.05756871
89	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.05201912
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05087394
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05056262
92	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02978122
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02669978
94	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02407986
95	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.01873562
96	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.00178545
97	SOX9_26525672_Chip-Seq_HEART_Mouse	0.98596236
98	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97513082
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97513082
100	JUN_21703547_ChIP-Seq_K562_Human	0.97329409

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.69108846
2	MP0001529_abnormal_vocalization	3.44669754
3	MP0006276_abnormal_autonomic_nervous	3.44286990
4	MP0003787_abnormal_imprinting	3.30706564
5	MP0001984_abnormal_olfaction	3.03778466
6	MP0003122_maternal_imprinting	2.54064406
7	MP0003121_genomic_imprinting	2.44527803
8	MP0000778_abnormal_nervous_system	2.40316544
9	MP0001968_abnormal_touch/_nociception	2.30793416
10	MP0002653_abnormal_ependyma_morphology	2.26515608
11	MP0002102_abnormal_ear_morphology	2.24890970
12	MP0005645_abnormal_hypothalamus_physiol	2.18729044
13	MP0002736_abnormal_nociception_after	2.12279083
14	MP0005394_taste/olfaction_phenotype	1.96627859
15	MP0005499_abnormal_olfactory_system	1.96627859
16	MP0009046_muscle_twitch	1.95968240
17	MP0002735_abnormal_chemical_nociception	1.94832354
18	MP0008789_abnormal_olfactory_epithelium	1.85196276
19	MP0004859_abnormal_synaptic_plasticity	1.82928965
20	MP0004133_heterotaxia	1.82649095
21	MP0005253_abnormal_eye_physiology	1.81034448
22	MP0009745_abnormal_behavioral_response	1.80329891
23	MP0001486_abnormal_startle_reflex	1.80101693
24	MP0003635_abnormal_synaptic_transmissio	1.72632650
25	MP0005551_abnormal_eye_electrophysiolog	1.72453165
26	MP0002572_abnormal_emotion/affect_behav	1.71699023
27	MP0004270_analgesia	1.69245722
28	MP0000569_abnormal_digit_pigmentation	1.68522964
29	MP0005084_abnormal_gallbladder_morpholo	1.63134801
30	MP0002928_abnormal_bile_duct	1.60270122
31	MP0008877_abnormal_DNA_methylation	1.59933457
32	MP0005248_abnormal_Harderian_gland	1.58919964
33	MP0002557_abnormal_social/conspecific_i	1.57921045
34	MP0005423_abnormal_somatic_nervous	1.56891990
35	MP0000631_abnormal_neuroendocrine_gland	1.53133315
36	MP0004924_abnormal_behavior	1.52459357
37	MP0005386_behavior/neurological_phenoty	1.52459357
38	MP0002063_abnormal_learning/memory/cond	1.50718749
39	MP0002734_abnormal_mechanical_nocicepti	1.48022922
40	MP0004742_abnormal_vestibular_system	1.46028925
41	MP0002822_catalepsy	1.45411248
42	MP0002282_abnormal_trachea_morphology	1.40066620
43	MP0000026_abnormal_inner_ear	1.38310655
44	MP0001485_abnormal_pinna_reflex	1.34699297
45	MP0005195_abnormal_posterior_eye	1.30599628
46	MP0002752_abnormal_somatic_nervous	1.30233397
47	MP0002272_abnormal_nervous_system	1.29765753
48	MP0004142_abnormal_muscle_tone	1.26489713
49	MP0000955_abnormal_spinal_cord	1.26421587
50	MP0001986_abnormal_taste_sensitivity	1.23787658
51	MP0003879_abnormal_hair_cell	1.23745498
52	MP0001970_abnormal_pain_threshold	1.23591193
53	MP0002876_abnormal_thyroid_physiology	1.22972333
54	MP0000647_abnormal_sebaceous_gland	1.22069982
55	MP0002064_seizures	1.18191919
56	MP0002751_abnormal_autonomic_nervous	1.16337734
57	MP0000372_irregular_coat_pigmentation	1.15175339
58	MP0002067_abnormal_sensory_capabilities	1.14951098
59	MP0000427_abnormal_hair_cycle	1.14575197
60	MP0005167_abnormal_blood-brain_barrier	1.14541788
61	MP0000465_gastrointestinal_hemorrhage	1.11441228
62	MP0002837_dystrophic_cardiac_calcinosis	1.07604079
63	MP0003724_increased_susceptibility_to	1.06345519
64	MP0002882_abnormal_neuron_morphology	1.05920000
65	MP0003195_calcinosis	1.04942921
66	MP0003136_yellow_coat_color	1.02693234
67	MP0005220_abnormal_exocrine_pancreas	1.00733209
68	MP0004885_abnormal_endolymph	1.00235511
69	MP0005075_abnormal_melanosome_morpholog	0.98745925
70	MP0002733_abnormal_thermal_nociception	0.96059303
71	MP0002184_abnormal_innervation	0.95942196
72	MP0001440_abnormal_grooming_behavior	0.95401643
73	MP0003221_abnormal_cardiomyocyte_apopto	0.94987272
74	MP0005391_vision/eye_phenotype	0.93291511
75	MP0008872_abnormal_physiological_respon	0.92687902
76	MP0003806_abnormal_nucleotide_metabolis	0.92286419
77	MP0003943_abnormal_hepatobiliary_system	0.91982865
78	MP0003567_abnormal_fetal_cardiomyocyte	0.91470291
79	MP0002069_abnormal_eating/drinking_beha	0.89194049
80	MP0003633_abnormal_nervous_system	0.87047924
81	MP0001963_abnormal_hearing_physiology	0.86531634
82	MP0006072_abnormal_retinal_apoptosis	0.85647543
83	MP0002152_abnormal_brain_morphology	0.84206546
84	MP0000383_abnormal_hair_follicle	0.81115383
85	MP0001286_abnormal_eye_development	0.78401814
86	MP0002066_abnormal_motor_capabilities/c	0.77129540
87	MP0003698_abnormal_male_reproductive	0.75862201
88	MP0005367_renal/urinary_system_phenotyp	0.75596465
89	MP0000516_abnormal_urinary_system	0.75596465
90	MP0003646_muscle_fatigue	0.75053560
91	MP0008775_abnormal_heart_ventricle	0.73851863
92	MP0005647_abnormal_sex_gland	0.70407872
93	MP0005266_abnormal_metabolism	0.68452239
94	MP0002938_white_spotting	0.67578788
95	MP0001293_anophthalmia	0.67300641
96	MP0002138_abnormal_hepatobiliary_system	0.66250744
97	MP0002090_abnormal_vision	0.65113737
98	MP0002229_neurodegeneration	0.64170949
99	MP0001502_abnormal_circadian_rhythm	0.63747267
100	MP0002249_abnormal_larynx_morphology	0.62867129

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	4.53641605
2	Retinal dysplasia (HP:0007973)	4.30952705
3	Medial flaring of the eyebrow (HP:0010747)	3.99181556
4	Hyperventilation (HP:0002883)	3.83089123
5	Molar tooth sign on MRI (HP:0002419)	3.83051978
6	Abnormality of midbrain morphology (HP:0002418)	3.83051978
7	Septo-optic dysplasia (HP:0100842)	3.80187585
8	True hermaphroditism (HP:0010459)	3.75322012
9	Nephrogenic diabetes insipidus (HP:0009806)	3.74881220
10	Pancreatic fibrosis (HP:0100732)	3.70591478
11	Polyphagia (HP:0002591)	3.68273950
12	Gait imbalance (HP:0002141)	3.55269308
13	Hip dysplasia (HP:0001385)	3.50311996
14	Congenital primary aphakia (HP:0007707)	3.47109830
15	Type II lissencephaly (HP:0007260)	3.47037005
16	Pancreatic cysts (HP:0001737)	3.34764152
17	Abnormal biliary tract physiology (HP:0012439)	3.30957973
18	Bile duct proliferation (HP:0001408)	3.30957973
19	Nephronophthisis (HP:0000090)	3.18573185
20	Amyotrophic lateral sclerosis (HP:0007354)	3.09243203
21	Atonic seizures (HP:0010819)	2.99061841
22	Neoplasm of the adrenal cortex (HP:0100641)	2.95346545
23	Cone-rod dystrophy (HP:0000548)	2.92478693
24	Hyperglycinemia (HP:0002154)	2.88239318
25	Occipital encephalocele (HP:0002085)	2.85689972
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.84234275
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.84234275
28	Colon cancer (HP:0003003)	2.77769500
29	Genital tract atresia (HP:0001827)	2.76514769
30	Vaginal atresia (HP:0000148)	2.74565065
31	Absent/shortened dynein arms (HP:0200106)	2.73043530
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73043530
33	Abnormal ciliary motility (HP:0012262)	2.71527608
34	Cystic liver disease (HP:0006706)	2.71349873
35	Methylmalonic aciduria (HP:0012120)	2.67616701
36	Febrile seizures (HP:0002373)	2.67073170
37	Decreased central vision (HP:0007663)	2.65154241
38	Abnormality of the renal medulla (HP:0100957)	2.63869603
39	Methylmalonic acidemia (HP:0002912)	2.61721788
40	Lissencephaly (HP:0001339)	2.61525222
41	Abnormality of the labia minora (HP:0012880)	2.61006326
42	Sclerocornea (HP:0000647)	2.60058739
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.58298888
44	Papilledema (HP:0001085)	2.56566052
45	Abnormal respiratory motile cilium physiology (HP:0012261)	2.54552979
46	Abolished electroretinogram (ERG) (HP:0000550)	2.50114937
47	Asplenia (HP:0001746)	2.47234769
48	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41693464
49	Pendular nystagmus (HP:0012043)	2.39599255
50	Poor coordination (HP:0002370)	2.38091611
51	Optic nerve hypoplasia (HP:0000609)	2.35722189
52	Intestinal atresia (HP:0011100)	2.31660035
53	Specific learning disability (HP:0001328)	2.29991850
54	Long foot (HP:0001833)	2.29248241
55	Epileptic encephalopathy (HP:0200134)	2.28955458
56	Absent speech (HP:0001344)	2.25752207
57	Focal seizures (HP:0007359)	2.24365431
58	Abnormal hair whorl (HP:0010721)	2.23929061
59	Growth hormone deficiency (HP:0000824)	2.23723123
60	Large for gestational age (HP:0001520)	2.22487254
61	Inability to walk (HP:0002540)	2.21870133
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18778953
63	Abnormal eating behavior (HP:0100738)	2.11973119
64	Focal motor seizures (HP:0011153)	2.07271064
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06717683
66	Drooling (HP:0002307)	2.05536088
67	Progressive inability to walk (HP:0002505)	2.03213053
68	Retinitis pigmentosa (HP:0000510)	2.02888385
69	Postaxial hand polydactyly (HP:0001162)	2.02697300
70	Increased corneal curvature (HP:0100692)	2.02053784
71	Keratoconus (HP:0000563)	2.02053784
72	Abnormal rod and cone electroretinograms (HP:0008323)	2.01196313
73	Congenital hepatic fibrosis (HP:0002612)	1.97757024
74	Chronic sinusitis (HP:0011109)	1.96718246
75	Stomach cancer (HP:0012126)	1.96633147
76	Bony spicule pigmentary retinopathy (HP:0007737)	1.94656387
77	Cerebellar dysplasia (HP:0007033)	1.93336361
78	Broad foot (HP:0001769)	1.92502134
79	Abnormality of the astrocytes (HP:0100707)	1.90683379
80	Astrocytoma (HP:0009592)	1.90683379
81	Ketosis (HP:0001946)	1.89690706
82	Abnormal pancreas size (HP:0012094)	1.89078081
83	Prominent nasal bridge (HP:0000426)	1.88465355
84	Postaxial foot polydactyly (HP:0001830)	1.86897009
85	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.86639680
86	Dialeptic seizures (HP:0011146)	1.85577867
87	Cortical dysplasia (HP:0002539)	1.85350133
88	Excessive salivation (HP:0003781)	1.85205263
89	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.83932144
90	Hepatoblastoma (HP:0002884)	1.82734376
91	Narrow forehead (HP:0000341)	1.82451578
92	Maternal diabetes (HP:0009800)	1.81906703
93	Aganglionic megacolon (HP:0002251)	1.77618240
94	Abnormality of glycine metabolism (HP:0010895)	1.76676476
95	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76676476
96	Tubulointerstitial nephritis (HP:0001970)	1.75680285
97	Short foot (HP:0001773)	1.74554570
98	Anencephaly (HP:0002323)	1.74370176
99	Oculomotor apraxia (HP:0000657)	1.74144226
100	Atelectasis (HP:0100750)	1.73339640

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.35718313
2	BCKDK	3.75242308
3	MARK1	3.01469382
4	PIM2	2.53945397
5	INSRR	2.47778369
6	BCR	2.43964074
7	MAP3K4	2.43621562
8	CDK19	2.38935699
9	ERBB3	2.33818335
10	TRIM28	2.27506177
11	BMPR1B	2.25494620
12	MAPK15	2.22396757
13	FGFR2	2.12578849
14	MAP2K7	1.99523621
15	CASK	1.86186249
16	MAPK13	1.85152766
17	SIK3	1.84141224
18	STK39	1.65760527
19	STK16	1.64559973
20	DYRK2	1.61706448
21	DYRK1B	1.59570941
22	WNK3	1.49007085
23	NUAK1	1.48342389
24	NTRK2	1.38169703
25	DAPK2	1.33704046
26	CSNK1G2	1.31691223
27	WNK1	1.29231291
28	NME1	1.26930761
29	ACVR1B	1.22149646
30	CCNB1	1.21271930
31	EPHB1	1.18720519
32	PRKCG	1.17772537
33	GRK1	1.15632811
34	TNK2	1.15074625
35	WNK4	1.13714279
36	OXSR1	1.11660924
37	DYRK3	1.08900200
38	CSNK1A1L	1.04844756
39	PRKCE	1.01896683
40	ADRBK2	1.00565351
41	CSNK1G3	1.00027228
42	PAK3	0.97697045
43	CSNK1G1	0.96993851
44	STK38L	0.92985764
45	KDR	0.88397719
46	PRKCH	0.87948671
47	PIK3CA	0.86023892
48	PRKAA1	0.81012113
49	MAP2K4	0.79259840
50	CAMK2A	0.77797298
51	PRKD2	0.77729813
52	MAP4K2	0.77011762
53	EPHA3	0.76566641
54	TAOK3	0.75334335
55	MINK1	0.74731800
56	LATS1	0.74661098
57	MAP3K5	0.74266535
58	FER	0.73526659
59	PLK2	0.72903707
60	MAP3K7	0.72878519
61	CDC7	0.71466683
62	EIF2AK3	0.69573666
63	SGK494	0.68992189
64	SGK223	0.68992189
65	CDK6	0.68448882
66	DAPK3	0.68032332
67	TEC	0.66603057
68	PIM1	0.65083896
69	ERBB4	0.64529406
70	ADRBK1	0.64410679
71	TNIK	0.58964988
72	PRKCZ	0.57899568
73	DAPK1	0.57531958
74	TGFBR1	0.56361954
75	PRKACB	0.52654459
76	CSNK1D	0.49335078
77	DYRK1A	0.48845090
78	PRKACA	0.48141118
79	FLT3	0.45342707
80	PINK1	0.43673094
81	CDK14	0.42655167
82	TIE1	0.42409003
83	CAMK1G	0.40677351
84	PAK6	0.39373193
85	CAMK4	0.39326878
86	BTK	0.38045312
87	CAMK1	0.36388666
88	ITK	0.36385880
89	CSNK1A1	0.35796817
90	CAMK2B	0.34268318
91	SGK2	0.31653416
92	PRKCA	0.31404291
93	CDK5	0.30639009
94	CAMK1D	0.30589587
95	STK11	0.29897424
96	MAPK4	0.29530130
97	ABL1	0.29034563
98	PRKACG	0.28173184
99	EPHB2	0.27906217
100	MAPK7	0.27578295

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.71570541
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.23046556
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.55613962
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.74069794
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.11887985
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.11640158
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.11421157
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.08921116
9	GABAergic synapse_Homo sapiens_hsa04727	1.97589538
10	Butanoate metabolism_Homo sapiens_hsa00650	1.93403383
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85413557
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84941333
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.83271091
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82713745
15	Propanoate metabolism_Homo sapiens_hsa00640	1.78773568
16	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.77499966
17	Phototransduction_Homo sapiens_hsa04744	1.76894768
18	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.74396392
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.71694962
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68277643
21	Morphine addiction_Homo sapiens_hsa05032	1.67703610
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.62445130
23	Fatty acid elongation_Homo sapiens_hsa00062	1.55522901
24	Taste transduction_Homo sapiens_hsa04742	1.53530203
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49535314
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.41440648
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.41258144
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.37251934
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.34648764
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34053006
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.31667855
32	Peroxisome_Homo sapiens_hsa04146	1.29054522
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.26880447
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26495009
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.24586909
36	Protein export_Homo sapiens_hsa03060	1.18857823
37	Sulfur relay system_Homo sapiens_hsa04122	1.18307857
38	Insulin secretion_Homo sapiens_hsa04911	1.15722080
39	Circadian entrainment_Homo sapiens_hsa04713	1.15623194
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10470581
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08098840
42	Regulation of autophagy_Homo sapiens_hsa04140	1.07365070
43	Olfactory transduction_Homo sapiens_hsa04740	1.07153155
44	Asthma_Homo sapiens_hsa05310	1.07020996
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05003499
46	RNA polymerase_Homo sapiens_hsa03020	0.97961403
47	Ribosome_Homo sapiens_hsa03010	0.95816548
48	Axon guidance_Homo sapiens_hsa04360	0.94961955
49	Huntingtons disease_Homo sapiens_hsa05016	0.93011516
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89487243
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.87172544
52	Parkinsons disease_Homo sapiens_hsa05012	0.84185274
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.80837084
54	RNA degradation_Homo sapiens_hsa03018	0.80506242
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.79880929
56	Homologous recombination_Homo sapiens_hsa03440	0.78687835
57	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.78146360
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.74958676
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73402345
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69015665
61	Metabolic pathways_Homo sapiens_hsa01100	0.65453914
62	Dopaminergic synapse_Homo sapiens_hsa04728	0.65104854
63	Notch signaling pathway_Homo sapiens_hsa04330	0.64475019
64	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.64050502
65	Lysine degradation_Homo sapiens_hsa00310	0.63353662
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.63037813
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.61857141
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60857552
69	Fatty acid degradation_Homo sapiens_hsa00071	0.60082459
70	Base excision repair_Homo sapiens_hsa03410	0.59971520
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.59257445
72	Purine metabolism_Homo sapiens_hsa00230	0.58591926
73	Serotonergic synapse_Homo sapiens_hsa04726	0.56577944
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.55040991
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53753614
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52787170
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50779691
78	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49666700
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48689212
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48510974
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47139183
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45118440
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.43375940
84	Cholinergic synapse_Homo sapiens_hsa04725	0.39935760
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39525564
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.37707613
87	Alzheimers disease_Homo sapiens_hsa05010	0.35702570
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34289673
89	Retinol metabolism_Homo sapiens_hsa00830	0.34067344
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33249650
91	Salivary secretion_Homo sapiens_hsa04970	0.32221519
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31929195
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.30991336
94	Caffeine metabolism_Homo sapiens_hsa00232	0.30956999
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30605912
96	Basal transcription factors_Homo sapiens_hsa03022	0.30146296
97	Hippo signaling pathway_Homo sapiens_hsa04390	0.29803747
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.25543208
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.24607779
100	Type I diabetes mellitus_Homo sapiens_hsa04940	0.24338893

OR7E117P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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