ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sulfation (GO:0051923)	6.37833272
2	positive regulation of cardiac muscle cell differentiation (GO:2000727)	5.85638561
3	cell proliferation in forebrain (GO:0021846)	5.37775633
4	positive regulation of synapse maturation (GO:0090129)	4.80201614
5	regulation of synapse maturation (GO:0090128)	4.72613127
6	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.61027331
7	cellular response to ATP (GO:0071318)	4.47555063
8	heart field specification (GO:0003128)	4.47384744
9	secondary heart field specification (GO:0003139)	4.47384744
10	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	4.36507455
11	TOR signaling (GO:0031929)	4.29020863
12	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	4.26897793
13	regulation of cell proliferation involved in kidney development (GO:1901722)	4.24495590
14	regulation of glomerulus development (GO:0090192)	4.22375567
15	otic vesicle formation (GO:0030916)	4.21901696
16	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	4.20505632
17	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	4.11448600
18	response to UV-C (GO:0010225)	4.09556569
19	positive regulation of protein homodimerization activity (GO:0090073)	4.08344878
20	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.05437572
21	regulation of phospholipid biosynthetic process (GO:0071071)	4.02345330
22	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.99701112
23	L-fucose catabolic process (GO:0042355)	3.97806450
24	fucose catabolic process (GO:0019317)	3.97806450
25	L-fucose metabolic process (GO:0042354)	3.97806450
26	regulation of DNA endoreduplication (GO:0032875)	3.80071666
27	regulation of germinal center formation (GO:0002634)	3.74899978
28	establishment of protein localization to vacuole (GO:0072666)	3.73589211
29	protein targeting to vacuole (GO:0006623)	3.73589211
30	protein targeting to lysosome (GO:0006622)	3.73589211
31	cAMP catabolic process (GO:0006198)	3.72811169
32	negative regulation of hormone biosynthetic process (GO:0032353)	3.67197958
33	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.66099600
34	behavioral response to nicotine (GO:0035095)	3.62036009
35	single strand break repair (GO:0000012)	3.61283337
36	gamma-aminobutyric acid transport (GO:0015812)	3.57294010
37	dentate gyrus development (GO:0021542)	3.55544072
38	regulation of cardiac muscle cell differentiation (GO:2000725)	3.55398555
39	negative regulation of systemic arterial blood pressure (GO:0003085)	3.53544087
40	positive regulation of protein autophosphorylation (GO:0031954)	3.52267725
41	limb bud formation (GO:0060174)	3.50608927
42	regulation of G0 to G1 transition (GO:0070316)	3.43488911
43	pharyngeal system development (GO:0060037)	3.41996200
44	positive regulation of muscle hypertrophy (GO:0014742)	3.40257628
45	positive regulation of cardiac muscle hypertrophy (GO:0010613)	3.40257628
46	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.32968085
47	resolution of meiotic recombination intermediates (GO:0000712)	3.27102140
48	cyclic nucleotide catabolic process (GO:0009214)	3.26791346
49	homocysteine metabolic process (GO:0050667)	3.22629309
50	negative regulation of DNA binding (GO:0043392)	3.21659973
51	mitochondrion distribution (GO:0048311)	3.20732781
52	positive regulation of fatty acid oxidation (GO:0046321)	3.20161973
53	DNA replication-dependent nucleosome organization (GO:0034723)	3.17246179
54	DNA replication-dependent nucleosome assembly (GO:0006335)	3.17246179
55	regulation of sarcomere organization (GO:0060297)	3.16296350
56	positive regulation of metanephros development (GO:0072216)	3.11770675
57	rRNA catabolic process (GO:0016075)	3.11690557
58	tooth mineralization (GO:0034505)	3.09846881
59	negative regulation of hormone metabolic process (GO:0032351)	3.07236104
60	regulation of DNA damage checkpoint (GO:2000001)	3.06715019
61	dorsal/ventral axis specification (GO:0009950)	3.04558395
62	regulation of sequestering of triglyceride (GO:0010889)	3.04036917
63	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.02158601
64	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.02158601
65	DNA double-strand break processing (GO:0000729)	3.02004636
66	N-acetylglucosamine metabolic process (GO:0006044)	3.01403361
67	specification of organ identity (GO:0010092)	2.99403578
68	positive regulation of myoblast differentiation (GO:0045663)	2.95858816
69	cartilage morphogenesis (GO:0060536)	2.95851554
70	activation of protein kinase B activity (GO:0032148)	2.92399278
71	negative regulation by host of viral transcription (GO:0043922)	2.92354033
72	central nervous system projection neuron axonogenesis (GO:0021952)	2.87846154
73	negative regulation of platelet activation (GO:0010544)	2.87197634
74	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.84090808
75	organ growth (GO:0035265)	2.82609846
76	interkinetic nuclear migration (GO:0022027)	2.80344117
77	intra-S DNA damage checkpoint (GO:0031573)	2.80338949
78	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.80232986
79	myoblast migration (GO:0051451)	2.78374563
80	negative regulation of Ras GTPase activity (GO:0034261)	2.76599949
81	chromosome organization involved in meiosis (GO:0070192)	2.72303138
82	pericardium development (GO:0060039)	2.70029983
83	cell wall macromolecule catabolic process (GO:0016998)	2.69092608
84	protein localization to lysosome (GO:0061462)	2.68592810
85	protein localization to vacuole (GO:0072665)	2.68592810
86	regulation of transcription regulatory region DNA binding (GO:2000677)	2.67688259
87	regulation of cardiac muscle cell contraction (GO:0086004)	2.67603580
88	regulation of posttranscriptional gene silencing (GO:0060147)	2.65228728
89	regulation of gene silencing by miRNA (GO:0060964)	2.65228728
90	regulation of gene silencing by RNA (GO:0060966)	2.65228728
91	histone exchange (GO:0043486)	2.65173451
92	epithelial cell fate commitment (GO:0072148)	2.64398260
93	pituitary gland development (GO:0021983)	2.60724961
94	negative chemotaxis (GO:0050919)	2.59041579
95	tryptophan metabolic process (GO:0006568)	2.58969957
96	flavonoid metabolic process (GO:0009812)	2.57467205
97	positive regulation of mRNA catabolic process (GO:0061014)	2.56495279
98	synaptonemal complex assembly (GO:0007130)	2.56293548
99	histone H3-K9 methylation (GO:0051567)	2.55271675
100	negative regulation of organelle assembly (GO:1902116)	2.54155903

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.39297045
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.56430988
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.37088275
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.18723564
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.85656570
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.71145420
7	EWS_26573619_Chip-Seq_HEK293_Human	2.60965521
8	FUS_26573619_Chip-Seq_HEK293_Human	2.47425741
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.45645251
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.44151124
11	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.25258065
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22313608
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.18186708
14	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.03109522
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02609101
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.95730558
17	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.94932274
18	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.89883736
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85632571
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.84815431
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.84815431
22	VDR_22108803_ChIP-Seq_LS180_Human	1.83926534
23	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.78286400
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77793348
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76890406
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.74328617
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.73449466
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70529198
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.69089489
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69089489
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.67470893
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66979925
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66286309
34	P300_19829295_ChIP-Seq_ESCs_Human	1.63431282
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61164294
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.58959160
37	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58409101
38	AHR_22903824_ChIP-Seq_MCF-7_Human	1.57688944
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.57298949
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53427066
41	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.51666260
42	STAT3_23295773_ChIP-Seq_U87_Human	1.49993770
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46273378
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44563892
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.41385513
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.40500540
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.39273392
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39033177
49	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.38175946
50	TP53_16413492_ChIP-PET_HCT116_Human	1.35450172
51	TCF4_23295773_ChIP-Seq_U87_Human	1.35155605
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34795038
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.33552085
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29896312
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28682182
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.26937913
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25788787
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18560142
59	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.13310220
60	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.12647470
61	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.12500655
62	KDM2B_26808549_Chip-Seq_REH_Human	1.12167666
63	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11614278
64	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.11565728
65	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10902450
66	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.09930562
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08676379
68	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.08066352
69	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.07528498
70	TAF15_26573619_Chip-Seq_HEK293_Human	1.05995072
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05463607
72	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.03799513
73	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.03775177
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03312088
75	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.03263991
76	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.03043656
77	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.02995403
78	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.02595283
79	RXR_22108803_ChIP-Seq_LS180_Human	1.02189928
80	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.01464884
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01457081
82	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01296831
83	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00778705
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00382628
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99824086
86	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.98360540
87	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.98174125
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97871794
89	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.97842691
90	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97708975
91	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.96255296
92	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.95054891
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.94878346
94	JUN_21703547_ChIP-Seq_K562_Human	0.92970047
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92626907
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92503186
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92227372
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92133007
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.91578852
100	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.91263102

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004885_abnormal_endolymph	4.04101405
2	MP0004134_abnormal_chest_morphology	3.42724806
3	MP0009250_abnormal_appendicular_skeleto	3.05400538
4	MP0000569_abnormal_digit_pigmentation	3.00080203
5	MP0001485_abnormal_pinna_reflex	2.99949949
6	MP0002735_abnormal_chemical_nociception	2.94127270
7	MP0003787_abnormal_imprinting	2.87551625
8	MP0008789_abnormal_olfactory_epithelium	2.79093470
9	MP0008877_abnormal_DNA_methylation	2.65504716
10	MP0010094_abnormal_chromosome_stability	2.63220715
11	MP0002160_abnormal_reproductive_system	2.57724009
12	MP0003890_abnormal_embryonic-extraembry	2.51308066
13	MP0002089_abnormal_postnatal_growth/wei	2.43694089
14	MP0006292_abnormal_olfactory_placode	2.41775037
15	MP0009053_abnormal_anal_canal	2.40965171
16	MP0008057_abnormal_DNA_replication	2.38314869
17	MP0000049_abnormal_middle_ear	2.30632604
18	MP0004145_abnormal_muscle_electrophysio	2.20144803
19	MP0005499_abnormal_olfactory_system	2.14218938
20	MP0005394_taste/olfaction_phenotype	2.14218938
21	MP0009840_abnormal_foam_cell	1.94235202
22	MP0005389_reproductive_system_phenotype	1.87869705
23	MP0005174_abnormal_tail_pigmentation	1.82718828
24	MP0003136_yellow_coat_color	1.76083914
25	MP0005171_absent_coat_pigmentation	1.64902633
26	MP0002138_abnormal_hepatobiliary_system	1.64134986
27	MP0003195_calcinosis	1.60794877
28	MP0008058_abnormal_DNA_repair	1.58332267
29	MP0001177_atelectasis	1.57965539
30	MP0000631_abnormal_neuroendocrine_gland	1.55625984
31	MP0009697_abnormal_copulation	1.44669697
32	MP0003111_abnormal_nucleus_morphology	1.44443266
33	MP0000516_abnormal_urinary_system	1.38061033
34	MP0005367_renal/urinary_system_phenotyp	1.38061033
35	MP0000678_abnormal_parathyroid_gland	1.37576298
36	MP0001919_abnormal_reproductive_system	1.35006288
37	MP0005646_abnormal_pituitary_gland	1.34453834
38	MP0008872_abnormal_physiological_respon	1.29783717
39	MP0001299_abnormal_eye_distance/	1.26625290
40	MP0004215_abnormal_myocardial_fiber	1.25153339
41	MP0005503_abnormal_tendon_morphology	1.19762606
42	MP0002249_abnormal_larynx_morphology	1.18115145
43	MP0002233_abnormal_nose_morphology	1.15096443
44	MP0000613_abnormal_salivary_gland	1.13300564
45	MP0000762_abnormal_tongue_morphology	1.11227256
46	MP0004130_abnormal_muscle_cell	1.10770722
47	MP0003119_abnormal_digestive_system	1.09280508
48	MP0000534_abnormal_ureter_morphology	1.09174095
49	MP0003646_muscle_fatigue	1.07360134
50	MP0000733_abnormal_muscle_development	1.06155053
51	MP0003077_abnormal_cell_cycle	1.02528464
52	MP0001440_abnormal_grooming_behavior	1.01590385
53	MP0004133_heterotaxia	1.00777054
54	MP0000428_abnormal_craniofacial_morphol	1.00081588
55	MP0001188_hyperpigmentation	0.99417874
56	MP0002116_abnormal_craniofacial_bone	0.99289676
57	MP0005551_abnormal_eye_electrophysiolog	0.99275877
58	MP0001270_distended_abdomen	0.97984947
59	MP0003638_abnormal_response/metabolism_	0.95687465
60	MP0005360_urolithiasis	0.95504658
61	MP0010368_abnormal_lymphatic_system	0.93885238
62	MP0002108_abnormal_muscle_morphology	0.93392195
63	MP0001929_abnormal_gametogenesis	0.93387409
64	MP0002752_abnormal_somatic_nervous	0.88937344
65	MP0003633_abnormal_nervous_system	0.88395146
66	MP0000681_abnormal_thyroid_gland	0.88319051
67	MP0001486_abnormal_startle_reflex	0.87349016
68	MP0005187_abnormal_penis_morphology	0.86387702
69	MP0003632_abnormal_nervous_system	0.84813534
70	MP0000470_abnormal_stomach_morphology	0.83573356
71	MP0000383_abnormal_hair_follicle	0.82998578
72	MP0004197_abnormal_fetal_growth/weight/	0.82485913
73	MP0009046_muscle_twitch	0.82425476
74	MP0003385_abnormal_body_wall	0.81605593
75	MP0000778_abnormal_nervous_system	0.79162756
76	MP0002653_abnormal_ependyma_morphology	0.79007590
77	MP0002114_abnormal_axial_skeleton	0.77653729
78	MP0002272_abnormal_nervous_system	0.77503243
79	MP0001293_anophthalmia	0.76729597
80	MP0001963_abnormal_hearing_physiology	0.75693526
81	MP0005386_behavior/neurological_phenoty	0.75563636
82	MP0004924_abnormal_behavior	0.75563636
83	MP0002837_dystrophic_cardiac_calcinosis	0.75443445
84	MP0001145_abnormal_male_reproductive	0.74693944
85	MP0002396_abnormal_hematopoietic_system	0.73987097
86	MP0000163_abnormal_cartilage_morphology	0.73537454
87	MP0005195_abnormal_posterior_eye	0.72817501
88	MP0000371_diluted_coat_color	0.72000343
89	MP0003936_abnormal_reproductive_system	0.71969791
90	MP0000653_abnormal_sex_gland	0.70974299
91	MP0003755_abnormal_palate_morphology	0.70970507
92	MP0000026_abnormal_inner_ear	0.70949613
93	MP0005076_abnormal_cell_differentiation	0.69942230
94	MP0002295_abnormal_pulmonary_circulatio	0.68603898
95	MP0002127_abnormal_cardiovascular_syste	0.68568700
96	MP0003631_nervous_system_phenotype	0.68263835
97	MP0002638_abnormal_pupillary_reflex	0.67033483
98	MP0009745_abnormal_behavioral_response	0.66962777
99	MP0003938_abnormal_ear_development	0.66891464
100	MP0000432_abnormal_head_morphology	0.66435469

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.85818386
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.34329264
3	Abnormality of chromosome stability (HP:0003220)	3.87280780
4	Abnormality of DNA repair (HP:0003254)	3.58509952
5	Congenital, generalized hypertrichosis (HP:0004540)	3.57865006
6	Progressive cerebellar ataxia (HP:0002073)	3.50737423
7	Action tremor (HP:0002345)	3.45442402
8	Porencephaly (HP:0002132)	3.23920068
9	Pancreatic fibrosis (HP:0100732)	3.06891822
10	Abnormality of homocysteine metabolism (HP:0010919)	3.04548021
11	Homocystinuria (HP:0002156)	3.04548021
12	Confusion (HP:0001289)	2.81543667
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.78284917
14	Thyroiditis (HP:0100646)	2.78164509
15	Chromsome breakage (HP:0040012)	2.77349647
16	B lymphocytopenia (HP:0010976)	2.77083084
17	Abnormality of the columella (HP:0009929)	2.73241307
18	Small hand (HP:0200055)	2.68912591
19	Conjunctival hamartoma (HP:0100780)	2.62875847
20	Hypoalphalipoproteinemia (HP:0003233)	2.60373484
21	Tented upper lip vermilion (HP:0010804)	2.58883951
22	True hermaphroditism (HP:0010459)	2.57050810
23	Asplenia (HP:0001746)	2.56647404
24	Hyperlipoproteinemia (HP:0010980)	2.55106992
25	Abnormality of B cell number (HP:0010975)	2.53487872
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.44185997
27	Hypoplastic pelvis (HP:0008839)	2.43127106
28	Hamartoma of the eye (HP:0010568)	2.42787676
29	Meckel diverticulum (HP:0002245)	2.40506996
30	Pancreatic cysts (HP:0001737)	2.38192347
31	Furrowed tongue (HP:0000221)	2.37245294
32	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.36824068
33	Pendular nystagmus (HP:0012043)	2.36446556
34	High anterior hairline (HP:0009890)	2.36274284
35	Hemiplegia (HP:0002301)	2.35942299
36	Abnormality of the ileum (HP:0001549)	2.34940852
37	Median cleft lip (HP:0000161)	2.34363974
38	Abnormality of the nasal septum (HP:0000419)	2.32194818
39	Abnormality of cochlea (HP:0000375)	2.31146453
40	Benign neoplasm of the central nervous system (HP:0100835)	2.28756178
41	Severe combined immunodeficiency (HP:0004430)	2.26154540
42	Congenital sensorineural hearing impairment (HP:0008527)	2.24434622
43	Gonadotropin excess (HP:0000837)	2.23773273
44	Meningioma (HP:0002858)	2.23399338
45	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.23127339
46	Short 1st metacarpal (HP:0010034)	2.23127339
47	Renal cortical cysts (HP:0000803)	2.23072779
48	IgG deficiency (HP:0004315)	2.22772199
49	Septo-optic dysplasia (HP:0100842)	2.21554422
50	Sloping forehead (HP:0000340)	2.21062688
51	Mesomelia (HP:0003027)	2.19868205
52	Cavernous hemangioma (HP:0001048)	2.18912248
53	Abnormality of the axillary hair (HP:0100134)	2.18572052
54	Abnormality of secondary sexual hair (HP:0009888)	2.18572052
55	Clubbing of toes (HP:0100760)	2.16389357
56	Methylmalonic acidemia (HP:0002912)	2.13449881
57	Intellectual disability, moderate (HP:0002342)	2.12068658
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11550606
59	Bone cyst (HP:0012062)	2.10959325
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10542769
61	Absent/shortened dynein arms (HP:0200106)	2.10542769
62	Short tibia (HP:0005736)	2.09832219
63	Visual hallucinations (HP:0002367)	2.09255136
64	2-3 toe syndactyly (HP:0004691)	2.08962659
65	Abolished electroretinogram (ERG) (HP:0000550)	2.08850264
66	Short 4th metacarpal (HP:0010044)	2.08611928
67	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.08611928
68	Abnormality of the carotid arteries (HP:0005344)	2.07537341
69	Ependymoma (HP:0002888)	2.04035442
70	Abnormality of the preputium (HP:0100587)	2.02983745
71	Glioma (HP:0009733)	2.02490425
72	Menstrual irregularities (HP:0000858)	2.01866848
73	Abnormality of the renal cortex (HP:0011035)	1.97931739
74	Truncal obesity (HP:0001956)	1.94444176
75	Adenoma sebaceum (HP:0009720)	1.93270878
76	Angiofibromas (HP:0010615)	1.93270878
77	Short phalanx of the thumb (HP:0009660)	1.92894337
78	Adactyly (HP:0009776)	1.90783435
79	Abnormality of the renal collecting system (HP:0004742)	1.90232509
80	Abnormality of the 1st metacarpal (HP:0010009)	1.89347354
81	Inability to walk (HP:0002540)	1.89340916
82	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.89279513
83	Agitation (HP:0000713)	1.87323307
84	Hypoplasia of the thymus (HP:0000778)	1.86294337
85	Short chin (HP:0000331)	1.82520680
86	Anencephaly (HP:0002323)	1.82188294
87	Fibular aplasia (HP:0002990)	1.81041944
88	Absent hand (HP:0004050)	1.80698018
89	Protruding tongue (HP:0010808)	1.80321364
90	Bell-shaped thorax (HP:0001591)	1.78976062
91	Abnormality of ocular smooth pursuit (HP:0000617)	1.78637409
92	Combined immunodeficiency (HP:0005387)	1.77659842
93	Volvulus (HP:0002580)	1.76091762
94	Absent thumb (HP:0009777)	1.75521518
95	Cupped ear (HP:0000378)	1.75282806
96	Congenital hepatic fibrosis (HP:0002612)	1.75056196
97	Short humerus (HP:0005792)	1.75028186
98	Nephronophthisis (HP:0000090)	1.73408793
99	Astrocytoma (HP:0009592)	1.73072552
100	Abnormality of the astrocytes (HP:0100707)	1.73072552

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK1	6.63702591
2	ACVR1B	4.43885202
3	PINK1	3.99855163
4	NTRK2	3.92846521
5	TLK1	3.82416881
6	BMPR1B	3.29624970
7	FRK	2.82047599
8	LATS1	2.51672833
9	MAP4K2	2.41040658
10	MAP3K9	2.34518490
11	PRKD2	2.23375388
12	AKT3	1.92364344
13	ZAK	1.72973562
14	TGFBR1	1.68165884
15	TNIK	1.61384669
16	GRK1	1.60346411
17	TAF1	1.59430015
18	CDC7	1.54916490
19	NUAK1	1.52314899
20	MELK	1.48597564
21	MARK3	1.46428235
22	CLK1	1.44638270
23	BRSK2	1.43438119
24	DYRK3	1.37853719
25	WEE1	1.32225380
26	VRK1	1.30949105
27	MAPK13	1.29876451
28	NEK2	1.24922786
29	GRK6	1.16282520
30	NEK9	1.16164968
31	PHKG1	1.15669661
32	PHKG2	1.15669661
33	CCNB1	1.12950736
34	FLT3	1.01550707
35	NLK	1.00700247
36	MAP3K10	0.98533848
37	CDK3	0.97182671
38	PKN2	0.96540734
39	STK38L	0.93135034
40	MST4	0.92810869
41	ADRBK2	0.81349575
42	EIF2AK3	0.80397791
43	TAOK3	0.77745950
44	MAPK7	0.77471763
45	BRAF	0.76917269
46	MAP2K1	0.74073717
47	PTK2B	0.73604505
48	STK3	0.73222763
49	CSNK1G1	0.70548402
50	RPS6KB1	0.68697975
51	CSNK1A1L	0.65317997
52	VRK2	0.62403672
53	PLK1	0.62359329
54	SGK2	0.62126527
55	CSNK1G3	0.61231917
56	BTK	0.60448707
57	OBSCN	0.59219208
58	RPS6KB2	0.58146250
59	PNCK	0.55291421
60	MAP3K13	0.54027448
61	TXK	0.53509781
62	SGK223	0.52902406
63	SGK494	0.52902406
64	TIE1	0.46133343
65	CSNK1G2	0.43558493
66	MAPK12	0.43152240
67	CHEK2	0.42970532
68	ATR	0.40235486
69	PKN1	0.40169664
70	PRKCQ	0.39966793
71	PRKG2	0.39022327
72	ATM	0.38406407
73	ERBB2	0.38074114
74	PBK	0.37384609
75	ARAF	0.36220813
76	BLK	0.33634371
77	MAPK15	0.33487421
78	CASK	0.33432059
79	MAPK11	0.32974818
80	TEC	0.31929488
81	LMTK2	0.31170205
82	MAP2K7	0.30852154
83	EIF2AK2	0.30645524
84	MAPK4	0.30375074
85	DYRK2	0.29012501
86	SGK1	0.28499373
87	CSNK1A1	0.28209197
88	ABL1	0.26324806
89	AURKA	0.23326820
90	IGF1R	0.22267860
91	PLK3	0.21087565
92	FGFR2	0.20991095
93	NTRK3	0.20580102
94	AURKB	0.20452001
95	CSNK1D	0.19448060
96	HCK	0.19414051
97	CSNK1E	0.18519856
98	CDK8	0.18070484
99	CHEK1	0.16115729
100	PRKD1	0.15740574

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	4.20838264
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.90436835
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.82315257
4	Homologous recombination_Homo sapiens_hsa03440	2.72547429
5	DNA replication_Homo sapiens_hsa03030	2.55364695
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.49207483
7	Caffeine metabolism_Homo sapiens_hsa00232	2.29282685
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.21374160
9	Circadian rhythm_Homo sapiens_hsa04710	2.05704605
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.93852307
11	Melanoma_Homo sapiens_hsa05218	1.89650549
12	Renin secretion_Homo sapiens_hsa04924	1.70553756
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67713730
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.67564898
15	Basal transcription factors_Homo sapiens_hsa03022	1.67538651
16	Nicotine addiction_Homo sapiens_hsa05033	1.59789850
17	Mismatch repair_Homo sapiens_hsa03430	1.58781768
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.52956278
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.51971883
20	Morphine addiction_Homo sapiens_hsa05032	1.49439954
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.42824295
22	One carbon pool by folate_Homo sapiens_hsa00670	1.32224163
23	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.31474924
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.31278851
25	Phototransduction_Homo sapiens_hsa04744	1.29899537
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.29804670
27	Gap junction_Homo sapiens_hsa04540	1.28702866
28	Olfactory transduction_Homo sapiens_hsa04740	1.28665518
29	Taste transduction_Homo sapiens_hsa04742	1.27581016
30	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.23950707
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.23605439
32	Alcoholism_Homo sapiens_hsa05034	1.13615732
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.13484223
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13187397
35	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.12917978
36	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.12140797
37	Base excision repair_Homo sapiens_hsa03410	1.08634109
38	RNA degradation_Homo sapiens_hsa03018	1.08136687
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.07033752
40	Basal cell carcinoma_Homo sapiens_hsa05217	1.04142380
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.03968357
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03655245
43	Wnt signaling pathway_Homo sapiens_hsa04310	1.02428734
44	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01376082
45	Salivary secretion_Homo sapiens_hsa04970	1.00908740
46	ABC transporters_Homo sapiens_hsa02010	0.99723846
47	Circadian entrainment_Homo sapiens_hsa04713	0.98585758
48	Glioma_Homo sapiens_hsa05214	0.92835943
49	Sphingolipid metabolism_Homo sapiens_hsa00600	0.91071974
50	Prostate cancer_Homo sapiens_hsa05215	0.90777453
51	Long-term depression_Homo sapiens_hsa04730	0.88797612
52	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.86822172
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.86789883
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85480693
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79726874
56	Sulfur metabolism_Homo sapiens_hsa00920	0.76897259
57	Purine metabolism_Homo sapiens_hsa00230	0.76026120
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.76019903
59	MicroRNAs in cancer_Homo sapiens_hsa05206	0.74764773
60	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.71966809
61	Type II diabetes mellitus_Homo sapiens_hsa04930	0.71713694
62	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.70748115
63	Spliceosome_Homo sapiens_hsa03040	0.70667986
64	Lysine degradation_Homo sapiens_hsa00310	0.69389474
65	Retinol metabolism_Homo sapiens_hsa00830	0.68191211
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67192035
67	Glucagon signaling pathway_Homo sapiens_hsa04922	0.67043624
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.66236256
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.64898047
70	Serotonergic synapse_Homo sapiens_hsa04726	0.64327528
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63094005
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.61797001
73	GABAergic synapse_Homo sapiens_hsa04727	0.60770586
74	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60143748
75	MAPK signaling pathway_Homo sapiens_hsa04010	0.59349120
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.59334613
77	Oocyte meiosis_Homo sapiens_hsa04114	0.59130827
78	RNA polymerase_Homo sapiens_hsa03020	0.57671897
79	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.57396683
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.57323211
81	Cholinergic synapse_Homo sapiens_hsa04725	0.56614353
82	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56593364
83	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55768891
84	FoxO signaling pathway_Homo sapiens_hsa04068	0.52149127
85	Insulin secretion_Homo sapiens_hsa04911	0.50877293
86	RNA transport_Homo sapiens_hsa03013	0.50869985
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49641146
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49485708
89	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.48661254
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.47520303
91	Thyroid cancer_Homo sapiens_hsa05216	0.45031840
92	Choline metabolism in cancer_Homo sapiens_hsa05231	0.43469646
93	Ras signaling pathway_Homo sapiens_hsa04014	0.41617502
94	Insulin resistance_Homo sapiens_hsa04931	0.40988141
95	p53 signaling pathway_Homo sapiens_hsa04115	0.40724750
96	Propanoate metabolism_Homo sapiens_hsa00640	0.37647542
97	Gastric acid secretion_Homo sapiens_hsa04971	0.37092365
98	Axon guidance_Homo sapiens_hsa04360	0.36866716
99	Cell cycle_Homo sapiens_hsa04110	0.36171577
100	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.35857592

OR7E126P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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