ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	replication fork processing (GO:0031297)	7.43834687
2	regulation of T cell tolerance induction (GO:0002664)	7.01103758
3	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	6.07107800
4	regulation of tolerance induction (GO:0002643)	5.82571534
5	positive regulation of mast cell activation involved in immune response (GO:0033008)	5.66301857
6	positive regulation of mast cell degranulation (GO:0043306)	5.66301857
7	T cell apoptotic process (GO:0070231)	5.58419038
8	DNA topological change (GO:0006265)	5.56214962
9	centriole replication (GO:0007099)	5.53993543
10	centrosome duplication (GO:0051298)	5.36688914
11	DNA replication-dependent nucleosome assembly (GO:0006335)	5.27913490
12	DNA replication-dependent nucleosome organization (GO:0034723)	5.27913490
13	cellular biogenic amine biosynthetic process (GO:0042401)	5.09383475
14	regulation of T cell cytokine production (GO:0002724)	5.06512733
15	resolution of meiotic recombination intermediates (GO:0000712)	4.87120265
16	positive regulation of granulocyte differentiation (GO:0030854)	4.85646817
17	nuclear pore complex assembly (GO:0051292)	4.79606019
18	amine biosynthetic process (GO:0009309)	4.72125465
19	lymphocyte apoptotic process (GO:0070227)	4.52318881
20	translesion synthesis (GO:0019985)	4.49778648
21	positive regulation of mast cell activation (GO:0033005)	4.46893497
22	DNA geometric change (GO:0032392)	4.35045757
23	DNA duplex unwinding (GO:0032508)	4.32978147
24	pore complex assembly (GO:0046931)	4.28964480
25	DNA strand renaturation (GO:0000733)	4.21270815
26	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	4.16072716
27	catechol-containing compound biosynthetic process (GO:0009713)	4.14784096
28	catecholamine biosynthetic process (GO:0042423)	4.14784096
29	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	4.06771155
30	positive regulation of leukocyte degranulation (GO:0043302)	4.00891675
31	centriole assembly (GO:0098534)	4.00363500
32	regulation of mast cell activation involved in immune response (GO:0033006)	4.00014677
33	peroxisome fission (GO:0016559)	3.99259731
34	nuclear pore organization (GO:0006999)	3.97859279
35	angiotensin maturation (GO:0002003)	3.94500093
36	mitotic sister chromatid segregation (GO:0000070)	3.88510442
37	sister chromatid segregation (GO:0000819)	3.79555442
38	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.78920259
39	cellular response to virus (GO:0098586)	3.60866601
40	DNA dealkylation (GO:0035510)	3.58149154
41	regulation of centrosome cycle (GO:0046605)	3.56632193
42	leukocyte apoptotic process (GO:0071887)	3.54823252
43	purine deoxyribonucleotide catabolic process (GO:0009155)	3.53558512
44	regulation of translational fidelity (GO:0006450)	3.50556013
45	endosome to melanosome transport (GO:0035646)	3.49548989
46	endosome to pigment granule transport (GO:0043485)	3.49548989
47	DNA conformation change (GO:0071103)	3.46759145
48	mitotic sister chromatid cohesion (GO:0007064)	3.45667220
49	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.44119641
50	postreplication repair (GO:0006301)	3.36460995
51	DNA unwinding involved in DNA replication (GO:0006268)	3.36184242
52	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.34842420
53	CENP-A containing nucleosome assembly (GO:0034080)	3.32525184
54	regulation of sister chromatid cohesion (GO:0007063)	3.29933331
55	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.27720586
56	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.27720586
57	mitotic nuclear envelope disassembly (GO:0007077)	3.25015964
58	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.24748577
59	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.24748577
60	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.24748577
61	chromatin remodeling at centromere (GO:0031055)	3.22240280
62	meiotic chromosome segregation (GO:0045132)	3.21531977
63	mitotic chromosome condensation (GO:0007076)	3.18917492
64	DNA replication-independent nucleosome organization (GO:0034724)	3.17891253
65	DNA replication-independent nucleosome assembly (GO:0006336)	3.17891253
66	regulation of hexokinase activity (GO:1903299)	3.17410514
67	regulation of glucokinase activity (GO:0033131)	3.17410514
68	heart valve formation (GO:0003188)	3.12227407
69	kinetochore organization (GO:0051383)	3.10724395
70	nucleoside diphosphate catabolic process (GO:0009134)	3.09548121
71	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.07065525
72	membrane disassembly (GO:0030397)	3.06608807
73	nuclear envelope disassembly (GO:0051081)	3.06608807
74	intra-S DNA damage checkpoint (GO:0031573)	3.03120047
75	peptidyl-lysine trimethylation (GO:0018023)	3.01024864
76	regulation of double-strand break repair (GO:2000779)	3.00635138
77	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.96574845
78	regulation of mast cell degranulation (GO:0043304)	2.96431234
79	centrosome organization (GO:0051297)	2.96412688
80	double-strand break repair via nonhomologous end joining (GO:0006303)	2.94777671
81	non-recombinational repair (GO:0000726)	2.94777671
82	regulation of mast cell activation (GO:0033003)	2.94468516
83	negative regulation of DNA recombination (GO:0045910)	2.94172598
84	chromatin assembly or disassembly (GO:0006333)	2.93950716
85	double-strand break repair via homologous recombination (GO:0000724)	2.93404711
86	monoubiquitinated protein deubiquitination (GO:0035520)	2.91580408
87	regulation of centrosome duplication (GO:0010824)	2.89748340
88	recombinational repair (GO:0000725)	2.88055467
89	regulation of centriole replication (GO:0046599)	2.87657158
90	centrosome localization (GO:0051642)	2.85648349
91	regulation of granulocyte differentiation (GO:0030852)	2.84973208
92	mitotic recombination (GO:0006312)	2.83904969
93	regulation of RNA export from nucleus (GO:0046831)	2.83578448
94	regulation of mitotic sister chromatid separation (GO:0010965)	2.83176130
95	regulation of mitotic sister chromatid segregation (GO:0033047)	2.83176130
96	regulation of sister chromatid segregation (GO:0033045)	2.83176130
97	telomere maintenance via recombination (GO:0000722)	2.83083016
98	DNA ligation (GO:0006266)	2.81554596
99	regulation of DNA recombination (GO:0000018)	2.81242677
100	imidazole-containing compound metabolic process (GO:0052803)	10.6762094

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.60567778
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.92097817
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.64757627
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.28781784
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.56445379
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.49671642
7	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.34103425
8	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.96523485
9	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.56507209
10	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.16869403
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.05322892
12	E2F7_22180533_ChIP-Seq_HELA_Human	10.1486450
13	IRF1_19129219_ChIP-ChIP_H3396_Human	1.91723961
14	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.90417362
15	VDR_21846776_ChIP-Seq_THP-1_Human	1.87602285
16	AR_21909140_ChIP-Seq_LNCAP_Human	1.83372953
17	MYC_22102868_ChIP-Seq_BL_Human	1.82779306
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.73702977
19	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.72633630
20	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.69967615
21	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.66723722
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.64456963
23	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.63105371
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60925082
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.58059900
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54498602
27	CIITA_25753668_ChIP-Seq_RAJI_Human	1.53880923
28	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.52143941
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51434721
30	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.49049680
31	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.48074652
32	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.41489999
33	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.39561506
34	SCL_19346495_ChIP-Seq_HPC-7_Human	1.38924217
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32735793
36	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32139059
37	MYB_26560356_Chip-Seq_TH2_Human	1.30959967
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30940293
39	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.30175418
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29937377
41	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.29545139
42	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29263982
43	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.27639912
44	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.23202811
45	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.21045340
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.20806916
47	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.18982381
48	GABP_19822575_ChIP-Seq_HepG2_Human	1.18921808
49	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.18887037
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.18850123
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.18454134
52	XRN2_22483619_ChIP-Seq_HELA_Human	1.17907661
53	MYB_26560356_Chip-Seq_TH1_Human	1.17864510
54	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.17122379
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.14946217
56	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.12996492
57	SPI1_23547873_ChIP-Seq_NB4_Human	1.12105534
58	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09528141
59	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.07777098
60	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.04575200
61	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.03627209
62	DCP1A_22483619_ChIP-Seq_HELA_Human	1.03350575
63	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.03149117
64	ELK1_19687146_ChIP-ChIP_HELA_Human	1.02076002
65	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.99794792
66	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.99591516
67	TFEB_21752829_ChIP-Seq_HELA_Human	0.98942382
68	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.96682450
69	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.95457370
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93502561
71	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.91660534
72	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.91546830
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89797879
74	NCOR1_26117541_ChIP-Seq_K562_Human	0.86433949
75	UTX_26944678_Chip-Seq_JUKART_Human	0.85968153
76	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.85904494
77	CHD1_26751641_Chip-Seq_LNCaP_Human	0.84748057
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.83509375
79	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.82183693
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.81588199
81	VDR_24763502_ChIP-Seq_THP-1_Human	0.81508164
82	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.80631859
83	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.80296272
84	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.79066410
85	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.76754724
86	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.76295424
87	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.75269299
88	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.74913444
89	TCF7_22412390_ChIP-Seq_EML_Mouse	0.74267168
90	ZNF263_19887448_ChIP-Seq_K562_Human	0.74115716
91	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.73354741
92	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.72967474
93	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.72280307
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.71080929
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.69472892
96	MAF_26560356_Chip-Seq_TH2_Human	0.69175633
97	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.68365500
98	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.65978694
99	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.65453326
100	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.64079043

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	6.17813756
2	MP0010094_abnormal_chromosome_stability	4.41548612
3	MP0008058_abnormal_DNA_repair	3.74730773
4	MP0003693_abnormal_embryo_hatching	3.67732550
5	MP0009697_abnormal_copulation	3.60298618
6	MP0003111_abnormal_nucleus_morphology	3.47851271
7	MP0002735_abnormal_chemical_nociception	3.46319991
8	MP0002396_abnormal_hematopoietic_system	2.70487249
9	MP0008877_abnormal_DNA_methylation	2.62271867
10	MP0009115_abnormal_fat_cell	2.55490669
11	MP0003077_abnormal_cell_cycle	2.44636047
12	MP0001873_stomach_inflammation	2.33252978
13	MP0003136_yellow_coat_color	2.25081281
14	MP0005075_abnormal_melanosome_morpholog	2.25053585
15	MP0005076_abnormal_cell_differentiation	2.21813007
16	MP0003787_abnormal_imprinting	2.11822553
17	MP0008961_abnormal_basal_metabolism	1.94734760
18	MP0004185_abnormal_adipocyte_glucose	1.92704157
19	MP0003763_abnormal_thymus_physiology	1.86723205
20	MP0004957_abnormal_blastocyst_morpholog	1.83738333
21	MP0002971_abnormal_brown_adipose	1.64290262
22	MP0000015_abnormal_ear_pigmentation	1.63833849
23	MP0002970_abnormal_white_adipose	1.62748452
24	MP0001730_embryonic_growth_arrest	1.62218721
25	MP0001188_hyperpigmentation	1.59334680
26	MP0000569_abnormal_digit_pigmentation	1.53404412
27	MP0000703_abnormal_thymus_morphology	1.46639242
28	MP0004808_abnormal_hematopoietic_stem	1.44697101
29	MP0005171_absent_coat_pigmentation	1.43548740
30	MP0002877_abnormal_melanocyte_morpholog	1.42468226
31	MP0008007_abnormal_cellular_replicative	1.40227559
32	MP0004381_abnormal_hair_follicle	1.33538111
33	MP0001348_abnormal_lacrimal_gland	1.33209136
34	MP0010307_abnormal_tumor_latency	1.29796222
35	MP0005220_abnormal_exocrine_pancreas	1.29367154
36	MP0001853_heart_inflammation	1.21064126
37	MP0002722_abnormal_immune_system	1.20493948
38	MP0002009_preneoplasia	1.19694038
39	MP0005174_abnormal_tail_pigmentation	1.19460014
40	MP0003984_embryonic_growth_retardation	1.17810138
41	MP0005334_abnormal_fat_pad	1.17666630
42	MP0005451_abnormal_body_composition	1.16107223
43	MP0000350_abnormal_cell_proliferation	1.15310870
44	MP0005310_abnormal_salivary_gland	1.14863080
45	MP0006292_abnormal_olfactory_placode	1.14135595
46	MP0002088_abnormal_embryonic_growth/wei	1.12997171
47	MP0001545_abnormal_hematopoietic_system	1.12911712
48	MP0005397_hematopoietic_system_phenotyp	1.12911712
49	MP0003221_abnormal_cardiomyocyte_apopto	1.11604770
50	MP0008260_abnormal_autophagy	1.10438394
51	MP0002398_abnormal_bone_marrow	1.09771931
52	MP0003718_maternal_effect	1.06619321
53	MP0005083_abnormal_biliary_tract	1.06513317
54	MP0002019_abnormal_tumor_incidence	1.05356090
55	MP0008932_abnormal_embryonic_tissue	1.02766830
56	MP0005621_abnormal_cell_physiology	1.02680023
57	MP0002086_abnormal_extraembryonic_tissu	1.00724964
58	MP0005380_embryogenesis_phenotype	0.98932236
59	MP0001672_abnormal_embryogenesis/_devel	0.98932236
60	MP0000689_abnormal_spleen_morphology	0.95733159
61	MP0000313_abnormal_cell_death	0.95570262
62	MP0002080_prenatal_lethality	0.95531124
63	MP0004197_abnormal_fetal_growth/weight/	0.95464104
64	MP0001697_abnormal_embryo_size	0.94976677
65	MP0002429_abnormal_blood_cell	0.92505599
66	MP0003121_genomic_imprinting	0.91249941
67	MP0000733_abnormal_muscle_development	0.90787015
68	MP0005384_cellular_phenotype	0.90053382
69	MP0000716_abnormal_immune_system	0.90029178
70	MP0003868_abnormal_feces_composition	0.90001498
71	MP0000371_diluted_coat_color	0.89967245
72	MP0003890_abnormal_embryonic-extraembry	0.88597997
73	MP0004264_abnormal_extraembryonic_tissu	0.88514294
74	MP0002405_respiratory_system_inflammati	0.86907350
75	MP0003567_abnormal_fetal_cardiomyocyte	0.84055854
76	MP0005666_abnormal_adipose_tissue	0.83409954
77	MP0003183_abnormal_peptide_metabolism	0.80561658
78	MP0003786_premature_aging	0.80364911
79	MP0000465_gastrointestinal_hemorrhage	0.79694741
80	MP0001800_abnormal_humoral_immune	0.78758937
81	MP0002734_abnormal_mechanical_nocicepti	0.78646481
82	MP0002733_abnormal_thermal_nociception	0.78390329
83	MP0009765_abnormal_xenobiotic_induced	0.75653519
84	MP0005448_abnormal_energy_balance	0.75457349
85	MP0001929_abnormal_gametogenesis	0.74416327
86	MP0002084_abnormal_developmental_patter	0.74285239
87	MP0009278_abnormal_bone_marrow	0.69976003
88	MP0002210_abnormal_sex_determination	0.69767614
89	MP0000372_irregular_coat_pigmentation	0.69606594
90	MP0002233_abnormal_nose_morphology	0.69428409
91	MP0001881_abnormal_mammary_gland	0.69386496
92	MP0005266_abnormal_metabolism	0.66706625
93	MP0000428_abnormal_craniofacial_morphol	0.66628559
94	MP0005503_abnormal_tendon_morphology	0.65503475
95	MP0010352_gastrointestinal_tract_polyps	0.65342575
96	MP0001145_abnormal_male_reproductive	0.64746768
97	MP0003656_abnormal_erythrocyte_physiolo	0.63803781
98	MP0002420_abnormal_adaptive_immunity	0.62201369
99	MP0009840_abnormal_foam_cell	0.61525548
100	MP0003385_abnormal_body_wall	0.61144086

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	6.56852538
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.50995377
3	Abnormality of chromosome stability (HP:0003220)	4.61248090
4	Male infertility (HP:0003251)	4.14529800
5	Volvulus (HP:0002580)	4.03896923
6	11 pairs of ribs (HP:0000878)	3.54496075
7	Facial hemangioma (HP:0000329)	3.39886959
8	Heterotopia (HP:0002282)	3.37690926
9	Failure to thrive in infancy (HP:0001531)	3.34335917
10	Orthostatic hypotension (HP:0001278)	3.20444648
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.07708143
12	Birth length less than 3rd percentile (HP:0003561)	3.06588736
13	Abnormal hair whorl (HP:0010721)	3.04545684
14	Acute lymphatic leukemia (HP:0006721)	3.02406852
15	Abnormality of the ileum (HP:0001549)	2.98226343
16	Meckel diverticulum (HP:0002245)	2.94656270
17	Myelodysplasia (HP:0002863)	2.91727964
18	Impulsivity (HP:0100710)	2.85017887
19	Abnormality of the preputium (HP:0100587)	2.83054560
20	Cellular immunodeficiency (HP:0005374)	2.83007637
21	Decreased lacrimation (HP:0000633)	2.81688218
22	Abnormality of DNA repair (HP:0003254)	2.81517498
23	Bone marrow hypocellularity (HP:0005528)	2.74009895
24	Capillary hemangiomas (HP:0005306)	2.71315437
25	Thrombocytosis (HP:0001894)	2.62274046
26	Clubbing of toes (HP:0100760)	2.59409779
27	Alacrima (HP:0000522)	2.58646520
28	Granulocytopenia (HP:0001913)	2.56521278
29	Glucose intolerance (HP:0000833)	2.54731058
30	Acute myeloid leukemia (HP:0004808)	2.54497592
31	Eosinophilia (HP:0001880)	2.53983849
32	Recurrent viral infections (HP:0004429)	2.53945140
33	Missing ribs (HP:0000921)	2.53547302
34	Premature graying of hair (HP:0002216)	2.53098085
35	Acute hepatic failure (HP:0006554)	2.52422790
36	Progressive external ophthalmoplegia (HP:0000590)	2.52218962
37	Sloping forehead (HP:0000340)	2.50580074
38	Rough bone trabeculation (HP:0100670)	2.47418588
39	Abnormality of the carotid arteries (HP:0005344)	2.46147206
40	Duplicated collecting system (HP:0000081)	2.40225763
41	Alveolar cell carcinoma (HP:0006519)	2.38876666
42	Neoplasm of the tracheobronchial system (HP:0100552)	2.34793486
43	Squamous cell carcinoma (HP:0002860)	2.33497183
44	Small intestinal stenosis (HP:0012848)	2.29757027
45	Duodenal stenosis (HP:0100867)	2.29757027
46	Autoimmune thrombocytopenia (HP:0001973)	2.24866571
47	Autoimmune hemolytic anemia (HP:0001890)	2.23702850
48	Nephroblastoma (Wilms tumor) (HP:0002667)	2.16203728
49	Neutropenia (HP:0001875)	2.10854076
50	Homocystinuria (HP:0002156)	2.10509232
51	Abnormality of homocysteine metabolism (HP:0010919)	2.10509232
52	Abnormality of the fingertips (HP:0001211)	2.10105718
53	Sandal gap (HP:0001852)	2.08815171
54	Abnormality of the renal collecting system (HP:0004742)	2.07221545
55	Ectopic kidney (HP:0000086)	2.06303205
56	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.05710289
57	Cafe-au-lait spot (HP:0000957)	2.05016165
58	Absent radius (HP:0003974)	2.04352592
59	Abnormality of pyrimidine metabolism (HP:0004353)	2.03592655
60	Abnormality of T cell physiology (HP:0011840)	2.00872243
61	Gonadotropin excess (HP:0000837)	1.99821966
62	Protruding tongue (HP:0010808)	1.97878353
63	T lymphocytopenia (HP:0005403)	1.97763379
64	Poikiloderma (HP:0001029)	1.97308458
65	Truncal obesity (HP:0001956)	1.97233419
66	Abnormality of the duodenum (HP:0002246)	1.96339544
67	Neoplasm of the oral cavity (HP:0100649)	1.95647624
68	Embryonal renal neoplasm (HP:0011794)	1.93793340
69	Selective tooth agenesis (HP:0001592)	1.93768933
70	Clitoromegaly (HP:0000057)	1.91312640
71	Reticulocytopenia (HP:0001896)	1.89785830
72	Thoracic kyphosis (HP:0002942)	1.89081800
73	Reduced antithrombin III activity (HP:0001976)	1.88745115
74	Increased nuchal translucency (HP:0010880)	1.88119167
75	Abnormality of eosinophils (HP:0001879)	1.87601259
76	Type I transferrin isoform profile (HP:0003642)	1.87472440
77	Absent thumb (HP:0009777)	1.87209344
78	Periodontitis (HP:0000704)	1.85801924
79	Basal cell carcinoma (HP:0002671)	1.85787008
80	Abnormality of the columella (HP:0009929)	1.84909575
81	Poor eye contact (HP:0000817)	1.84457967
82	Absent forearm bone (HP:0003953)	1.84406537
83	Aplasia involving forearm bones (HP:0009822)	1.84406537
84	Abnormality of T cells (HP:0002843)	1.83035781
85	Prominent nose (HP:0000448)	1.80935638
86	Dysautonomia (HP:0002459)	1.80851279
87	Abnormality of T cell number (HP:0011839)	1.80456035
88	Multiple enchondromatosis (HP:0005701)	1.71887461
89	Renal cortical cysts (HP:0000803)	1.70070538
90	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.69620686
91	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.68599545
92	High pitched voice (HP:0001620)	1.68582158
93	Agammaglobulinemia (HP:0004432)	1.67720835
94	Abnormality of the thymus (HP:0000777)	1.67269651
95	Panhypogammaglobulinemia (HP:0003139)	1.65790250
96	Abnormality of the prostate (HP:0008775)	1.65528476
97	Tracheoesophageal fistula (HP:0002575)	1.64479825
98	Abnormality of the thoracic spine (HP:0100711)	1.63980412
99	Lymphoma (HP:0002665)	1.63674060
100	Self-mutilation (HP:0000742)	1.63664604

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	8.99111377
2	CDK12	3.79665764
3	NEK2	2.68585416
4	CDC7	2.52032751
5	EIF2AK3	2.43475427
6	CCNB1	2.29231729
7	CAMK1G	2.28963070
8	TNIK	2.19557627
9	PBK	2.14838222
10	TNK2	2.11524439
11	PIK3CA	1.95503916
12	CAMK1D	1.88785936
13	WEE1	1.76646529
14	ATR	1.71324245
15	TAOK1	1.56722361
16	EIF2AK1	1.55791518
17	FRK	1.53664998
18	WNK1	1.53643940
19	PNCK	1.48956776
20	BRAF	1.46502191
21	AKT3	1.41694111
22	BRD4	1.33710077
23	BRSK2	1.32103076
24	TTK	1.32102190
25	NUAK1	1.30049207
26	PIM2	1.21523080
27	RPS6KB2	1.18844831
28	CDK7	1.17951185
29	CHEK1	1.17622173
30	RAF1	1.15774176
31	GRK6	1.15553970
32	TAF1	1.11080654
33	BUB1	1.10062546
34	BMPR1B	1.06952951
35	MKNK2	0.99158041
36	MARK3	0.97989028
37	EIF2AK2	0.96694917
38	CDK4	0.90827759
39	CHEK2	0.87367159
40	KDR	0.84513621
41	CDK6	0.84236038
42	FER	0.83372600
43	PDK2	0.81138982
44	PRKD2	0.80124125
45	VRK2	0.79257630
46	PLK1	0.79001239
47	IKBKE	0.77510816
48	ATM	0.76779660
49	ARAF	0.76718394
50	STK3	0.74427742
51	PIM1	0.74034608
52	CDK9	0.72255503
53	PLK4	0.71659811
54	WNK3	0.68716087
55	STK10	0.66969132
56	MAP3K10	0.65535656
57	VRK1	0.64969956
58	MARK2	0.62858248
59	WNK4	0.62121613
60	AURKB	0.61996835
61	CDK2	0.61247382
62	MAP4K1	0.58923689
63	CDK1	0.58592201
64	TEC	0.58384532
65	PLK3	0.53975590
66	MKNK1	0.53170738
67	STK39	0.52748972
68	MAP3K8	0.50896506
69	STK38	0.50646094
70	PRKCI	0.49654667
71	CHUK	0.47794880
72	HIPK2	0.47676689
73	MAPK10	0.47388327
74	ICK	0.47337718
75	RPS6KA4	0.46962769
76	BTK	0.46167784
77	AKT1	0.45301384
78	TRPM7	0.45092366
79	DYRK3	0.43415499
80	PRKDC	0.42954001
81	CDK3	0.42834378
82	MTOR	0.42387468
83	STK4	0.41995399
84	SRPK1	0.41559380
85	ERBB2	0.38201713
86	RPS6KA5	0.37362968
87	MAP3K2	0.37225840
88	MELK	0.31848193
89	TYK2	0.31309504
90	PRKCH	0.30422426
91	MAPK14	0.30094137
92	IRAK3	0.28466054
93	LYN	0.28415067
94	TRIB3	0.28330529
95	CSNK1E	0.27746623
96	TESK2	0.27481695
97	DMPK	0.26883733
98	GSK3B	0.26434596
99	PRKAA1	0.24968006
100	PLK2	0.24391307

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	4.17639070
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.72742641
3	Homologous recombination_Homo sapiens_hsa03440	3.41545157
4	DNA replication_Homo sapiens_hsa03030	3.35979938
5	Renin-angiotensin system_Homo sapiens_hsa04614	3.07238243
6	Mismatch repair_Homo sapiens_hsa03430	2.88271697
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.74174300
8	Cell cycle_Homo sapiens_hsa04110	2.59646058
9	Asthma_Homo sapiens_hsa05310	2.38094458
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.14946091
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.14786644
12	mRNA surveillance pathway_Homo sapiens_hsa03015	2.09205531
13	Oocyte meiosis_Homo sapiens_hsa04114	1.99193936
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.94658087
15	Spliceosome_Homo sapiens_hsa03040	1.93908049
16	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.82404231
17	Non-small cell lung cancer_Homo sapiens_hsa05223	1.78764619
18	RNA degradation_Homo sapiens_hsa03018	1.66806764
19	RNA transport_Homo sapiens_hsa03013	1.58297331
20	RNA polymerase_Homo sapiens_hsa03020	1.57595397
21	Other glycan degradation_Homo sapiens_hsa00511	1.53075944
22	Base excision repair_Homo sapiens_hsa03410	1.50135858
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.44001891
24	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.40791714
25	p53 signaling pathway_Homo sapiens_hsa04115	1.38188100
26	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.35313975
27	Peroxisome_Homo sapiens_hsa04146	1.33027315
28	Lysine degradation_Homo sapiens_hsa00310	1.23041139
29	Hepatitis B_Homo sapiens_hsa05161	1.13399472
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07822296
31	Prostate cancer_Homo sapiens_hsa05215	1.05715359
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05109245
33	MicroRNAs in cancer_Homo sapiens_hsa05206	1.04792447
34	Basal transcription factors_Homo sapiens_hsa03022	1.02668339
35	Colorectal cancer_Homo sapiens_hsa05210	1.02484302
36	Glioma_Homo sapiens_hsa05214	1.01436637
37	Acute myeloid leukemia_Homo sapiens_hsa05221	0.98862305
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.98709118
39	Pancreatic cancer_Homo sapiens_hsa05212	0.98675190
40	Fatty acid metabolism_Homo sapiens_hsa01212	0.94323427
41	Hepatitis C_Homo sapiens_hsa05160	0.93430044
42	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.93164132
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.91209832
44	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.89612240
45	Thyroid cancer_Homo sapiens_hsa05216	0.83834012
46	Measles_Homo sapiens_hsa05162	0.79418886
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78568256
48	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.77052766
49	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.73946249
50	Apoptosis_Homo sapiens_hsa04210	0.73138586
51	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.71899837
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.71755877
53	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.65595266
54	Bladder cancer_Homo sapiens_hsa05219	0.65019151
55	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64521857
56	Viral carcinogenesis_Homo sapiens_hsa05203	0.64073716
57	Endometrial cancer_Homo sapiens_hsa05213	0.62299795
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.62297195
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.60704010
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.59115055
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.57977153
62	Small cell lung cancer_Homo sapiens_hsa05222	0.57207935
63	ABC transporters_Homo sapiens_hsa02010	0.56555408
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.55658346
65	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.53683742
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.53555211
67	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.53087434
68	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.51953988
69	Phenylalanine metabolism_Homo sapiens_hsa00360	0.50072352
70	Melanoma_Homo sapiens_hsa05218	0.49956549
71	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49932048
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49764773
73	Pancreatic secretion_Homo sapiens_hsa04972	0.49711182
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.49707342
75	Insulin resistance_Homo sapiens_hsa04931	0.48648676
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48340667
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48005932
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47729968
79	Butanoate metabolism_Homo sapiens_hsa00650	0.46651982
80	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46492072
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.42320544
82	AMPK signaling pathway_Homo sapiens_hsa04152	0.41652423
83	Propanoate metabolism_Homo sapiens_hsa00640	0.41285520
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40095098
85	mTOR signaling pathway_Homo sapiens_hsa04150	0.38540581
86	Purine metabolism_Homo sapiens_hsa00230	0.38364272
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37491875
88	Herpes simplex infection_Homo sapiens_hsa05168	0.32642528
89	One carbon pool by folate_Homo sapiens_hsa00670	0.32586309
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32530839
91	Insulin signaling pathway_Homo sapiens_hsa04910	0.32422120
92	Caffeine metabolism_Homo sapiens_hsa00232	0.31027079
93	Notch signaling pathway_Homo sapiens_hsa04330	0.29993565
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28352521
95	Platelet activation_Homo sapiens_hsa04611	0.27664426
96	HTLV-I infection_Homo sapiens_hsa05166	0.27623369
97	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.27183218
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27096094
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.26883934
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.25662244

OR7E128P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »