OR7E12P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.93213228
2DNA replication checkpoint (GO:0000076)4.91707026
3regulation of posttranscriptional gene silencing (GO:0060147)4.86573067
4regulation of gene silencing by miRNA (GO:0060964)4.86573067
5regulation of gene silencing by RNA (GO:0060966)4.86573067
6CENP-A containing nucleosome assembly (GO:0034080)4.79971768
7protein localization to kinetochore (GO:0034501)4.40995666
8histone exchange (GO:0043486)4.24543748
9regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.01365518
10regulation of mitotic spindle checkpoint (GO:1903504)4.01365518
11DNA replication-independent nucleosome organization (GO:0034724)4.00016673
12DNA replication-independent nucleosome assembly (GO:0006336)4.00016673
13purine nucleobase biosynthetic process (GO:0009113)3.95983580
14nuclear pore complex assembly (GO:0051292)3.95416711
15pre-miRNA processing (GO:0031054)3.89133585
16regulation of helicase activity (GO:0051095)3.86550713
17negative regulation of mitotic sister chromatid separation (GO:2000816)3.83848581
18negative regulation of sister chromatid segregation (GO:0033046)3.83848581
19negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.83848581
20negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.83848581
21negative regulation of mitotic sister chromatid segregation (GO:0033048)3.83848581
22negative regulation of chromosome segregation (GO:0051985)3.77203455
23establishment of integrated proviral latency (GO:0075713)3.75249109
24DNA strand elongation involved in DNA replication (GO:0006271)3.72125422
25mitotic metaphase plate congression (GO:0007080)3.69177275
26IMP biosynthetic process (GO:0006188)3.68012709
27mitotic G2/M transition checkpoint (GO:0044818)3.59836047
28regulation of histone H3-K9 methylation (GO:0051570)3.58128423
29nucleobase biosynthetic process (GO:0046112)3.54942108
30nuclear pore organization (GO:0006999)3.54467387
31DNA strand elongation (GO:0022616)3.53164609
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52150526
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.45887956
34kinetochore organization (GO:0051383)3.45498943
35maturation of SSU-rRNA (GO:0030490)3.44279384
36heterochromatin organization (GO:0070828)3.40637651
37spindle checkpoint (GO:0031577)3.39745033
38mitotic spindle checkpoint (GO:0071174)3.39497204
39ribosomal small subunit assembly (GO:0000028)3.35183754
40telomere maintenance via semi-conservative replication (GO:0032201)3.32064238
41regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.29848016
42regulation of mitotic metaphase/anaphase transition (GO:0030071)3.29848016
43protein localization to chromosome, centromeric region (GO:0071459)3.29668788
44IMP metabolic process (GO:0046040)3.26215379
45telomere maintenance via telomerase (GO:0007004)3.25297155
46mitotic spindle assembly checkpoint (GO:0007094)3.24890529
47kinetochore assembly (GO:0051382)3.23943160
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.22961581
49regulation of sister chromatid segregation (GO:0033045)3.22196033
50regulation of mitotic sister chromatid separation (GO:0010965)3.22196033
51regulation of mitotic sister chromatid segregation (GO:0033047)3.22196033
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.21027612
53regulation of translation, ncRNA-mediated (GO:0045974)3.21027612
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21027612
55regulation of centriole replication (GO:0046599)3.19987558
56spindle assembly checkpoint (GO:0071173)3.19930722
57ATP-dependent chromatin remodeling (GO:0043044)3.15990448
58negative regulation of mitosis (GO:0045839)3.15341243
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13667032
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.13667032
61DNA replication-dependent nucleosome assembly (GO:0006335)3.12135669
62DNA replication-dependent nucleosome organization (GO:0034723)3.12135669
63metaphase plate congression (GO:0051310)3.12050051
64DNA topological change (GO:0006265)3.08683506
65regulation of nuclear cell cycle DNA replication (GO:0033262)3.03547964
66L-serine metabolic process (GO:0006563)3.00817174
67ribosomal large subunit biogenesis (GO:0042273)3.00175888
68regulation of chromosome segregation (GO:0051983)2.98926356
69negative regulation of histone methylation (GO:0031061)2.97781886
70telomere maintenance via recombination (GO:0000722)2.97742322
71mitotic sister chromatid segregation (GO:0000070)2.95555387
72negative regulation of DNA recombination (GO:0045910)2.94524983
73mitotic recombination (GO:0006312)2.94404432
74chromatin assembly or disassembly (GO:0006333)2.93516487
75DNA replication initiation (GO:0006270)2.91800941
76translational termination (GO:0006415)2.90029690
77mitotic nuclear envelope disassembly (GO:0007077)2.88676484
78proteasome assembly (GO:0043248)2.87555169
79mitotic chromosome condensation (GO:0007076)2.87280656
80regulation of cell fate specification (GO:0042659)2.86900163
81regulation of double-strand break repair via homologous recombination (GO:0010569)2.86420298
82negative regulation of telomerase activity (GO:0051974)2.86193824
83intra-S DNA damage checkpoint (GO:0031573)2.85209014
84paraxial mesoderm development (GO:0048339)2.84349950
85sister chromatid segregation (GO:0000819)2.84286496
86regulation of gene silencing (GO:0060968)2.82732776
87termination of RNA polymerase III transcription (GO:0006386)2.81029354
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.81029354
89regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.80817156
90viral transcription (GO:0019083)2.80532025
91pore complex assembly (GO:0046931)2.79762469
92DNA unwinding involved in DNA replication (GO:0006268)2.78883067
93resolution of meiotic recombination intermediates (GO:0000712)2.77996191
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76685963
95ATP synthesis coupled proton transport (GO:0015986)2.76685963
96regulation of DNA endoreduplication (GO:0032875)2.76013745
97telomere maintenance via telomere lengthening (GO:0010833)2.75830313
98replication fork processing (GO:0031297)2.75396479
99DNA ligation (GO:0006266)2.74528536
100centriole replication (GO:0007099)2.73066777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05777860
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19772436
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.88552770
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.73649088
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59022824
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.25441279
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.21108515
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.96712174
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96165752
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.79211184
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52620392
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50502065
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.47174524
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42790914
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38859533
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31018695
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21131367
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.18201807
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.18201807
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.18201807
21ELK1_19687146_ChIP-ChIP_HELA_Human2.18157521
22SOX2_16153702_ChIP-ChIP_HESCs_Human2.16189089
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12324748
24POU5F1_16153702_ChIP-ChIP_HESCs_Human2.11168083
25NANOG_16153702_ChIP-ChIP_HESCs_Human2.11138945
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.06395267
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05393882
28AR_21909140_ChIP-Seq_LNCAP_Human2.00479805
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.95799096
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94986138
31VDR_22108803_ChIP-Seq_LS180_Human1.87945490
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87614359
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84848138
34TTF2_22483619_ChIP-Seq_HELA_Human1.84795578
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82984469
36EWS_26573619_Chip-Seq_HEK293_Human1.80065201
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76553367
38FUS_26573619_Chip-Seq_HEK293_Human1.75798917
39MYC_18940864_ChIP-ChIP_HL60_Human1.73901332
40XRN2_22483619_ChIP-Seq_HELA_Human1.72365376
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67821583
42FOXP3_21729870_ChIP-Seq_TREG_Human1.67406628
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62940555
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59777776
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57223286
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57217173
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55910319
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55687511
49VDR_23849224_ChIP-Seq_CD4+_Human1.47231852
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45997480
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45288070
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42871445
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39532674
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.39062555
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31306298
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28158962
57DCP1A_22483619_ChIP-Seq_HELA_Human1.27273756
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.26919923
59SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24792700
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.23230261
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22475506
62ZNF274_21170338_ChIP-Seq_K562_Hela1.22121341
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19197039
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14776443
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14539887
66IRF1_19129219_ChIP-ChIP_H3396_Human1.14268372
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11267700
68P300_19829295_ChIP-Seq_ESCs_Human1.07413715
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06840394
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.06481046
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03744661
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03394602
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01990302
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01823295
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01057939
76WT1_19549856_ChIP-ChIP_CCG9911_Human0.99925629
77YY1_21170310_ChIP-Seq_MESCs_Mouse0.99178589
78GABP_19822575_ChIP-Seq_HepG2_Human0.98079933
79TAF15_26573619_Chip-Seq_HEK293_Human0.93942873
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93638369
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90461584
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90326581
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90227945
84TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89639388
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88319087
86IGF1R_20145208_ChIP-Seq_DFB_Human0.87356698
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84864057
88KDM5A_27292631_Chip-Seq_BREAST_Human0.84414440
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.82470694
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82399220
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80214341
92POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76752979
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.73760203
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73046003
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.70685202
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.70431132
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70404168
98SOX9_26525672_Chip-Seq_HEART_Mouse0.70334220
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70150386
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67782078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.45661244
2MP0003693_abnormal_embryo_hatching3.84179665
3MP0003941_abnormal_skin_development3.61292971
4MP0004957_abnormal_blastocyst_morpholog3.45222482
5MP0003890_abnormal_embryonic-extraembry3.33246689
6MP0010094_abnormal_chromosome_stability3.24585505
7MP0008058_abnormal_DNA_repair3.21746811
8MP0003111_abnormal_nucleus_morphology2.96016590
9MP0008932_abnormal_embryonic_tissue2.63848595
10MP0003136_yellow_coat_color2.56533488
11MP0001293_anophthalmia2.52164880
12MP0008057_abnormal_DNA_replication2.50772378
13MP0003567_abnormal_fetal_cardiomyocyte2.37909325
14MP0003077_abnormal_cell_cycle2.34116289
15MP0010030_abnormal_orbit_morphology2.31921644
16MP0008877_abnormal_DNA_methylation2.22412123
17MP0002254_reproductive_system_inflammat2.18234596
18MP0003937_abnormal_limbs/digits/tail_de2.15360126
19MP0009379_abnormal_foot_pigmentation2.13363935
20MP0003718_maternal_effect2.09724964
21MP0008007_abnormal_cellular_replicative1.84548791
22MP0003119_abnormal_digestive_system1.75888041
23MP0009697_abnormal_copulation1.66828133
24MP0002938_white_spotting1.66083003
25MP0002084_abnormal_developmental_patter1.64887277
26MP0009672_abnormal_birth_weight1.61987319
27MP0003786_premature_aging1.61434695
28MP0004133_heterotaxia1.58941575
29MP0002085_abnormal_embryonic_tissue1.58904268
30MP0001730_embryonic_growth_arrest1.54789862
31MP0001286_abnormal_eye_development1.54695976
32MP0008995_early_reproductive_senescence1.54097146
33MP0006072_abnormal_retinal_apoptosis1.48727079
34MP0002697_abnormal_eye_size1.46201512
35MP0000049_abnormal_middle_ear1.45983247
36MP0001672_abnormal_embryogenesis/_devel1.44552038
37MP0005380_embryogenesis_phenotype1.44552038
38MP0001697_abnormal_embryo_size1.39982658
39MP0000350_abnormal_cell_proliferation1.34706583
40MP0001188_hyperpigmentation1.31218887
41MP0000631_abnormal_neuroendocrine_gland1.27593989
42MP0002160_abnormal_reproductive_system1.24094477
43MP0004147_increased_porphyrin_level1.22295956
44MP0010307_abnormal_tumor_latency1.22227957
45MP0002111_abnormal_tail_morphology1.21953030
46MP0000428_abnormal_craniofacial_morphol1.21184761
47MP0003984_embryonic_growth_retardation1.20437144
48MP0003938_abnormal_ear_development1.19678754
49MP0001299_abnormal_eye_distance/1.19509048
50MP0002088_abnormal_embryonic_growth/wei1.17861899
51MP0002233_abnormal_nose_morphology1.17775950
52MP0002210_abnormal_sex_determination1.16850512
53MP0009703_decreased_birth_body1.15291878
54MP0003121_genomic_imprinting1.14531152
55MP0003123_paternal_imprinting1.10286206
56MP0001929_abnormal_gametogenesis1.06761656
57MP0002080_prenatal_lethality1.02646978
58MP0008789_abnormal_olfactory_epithelium1.02528843
59MP0000537_abnormal_urethra_morphology1.02130132
60MP0004197_abnormal_fetal_growth/weight/1.01396036
61MP0005499_abnormal_olfactory_system1.01168405
62MP0005394_taste/olfaction_phenotype1.01168405
63MP0003861_abnormal_nervous_system1.00358310
64MP0002751_abnormal_autonomic_nervous0.97295449
65MP0001145_abnormal_male_reproductive0.96733570
66MP0006035_abnormal_mitochondrial_morpho0.95041247
67MP0000653_abnormal_sex_gland0.93172264
68MP0000579_abnormal_nail_morphology0.90776864
69MP0003942_abnormal_urinary_system0.90326854
70MP0000647_abnormal_sebaceous_gland0.90204923
71MP0001529_abnormal_vocalization0.90105030
72MP0000566_synostosis0.89745007
73MP0005410_abnormal_fertilization0.88042797
74MP0000313_abnormal_cell_death0.86449931
75MP0002086_abnormal_extraembryonic_tissu0.86214802
76MP0003698_abnormal_male_reproductive0.83465798
77MP0000432_abnormal_head_morphology0.81924995
78MP0003755_abnormal_palate_morphology0.79817878
79MP0004145_abnormal_muscle_electrophysio0.79688244
80MP0001177_atelectasis0.79636276
81MP0003385_abnormal_body_wall0.78195384
82MP0005389_reproductive_system_phenotype0.76925025
83MP0005391_vision/eye_phenotype0.76831809
84MP0004272_abnormal_basement_membrane0.75977883
85MP0009250_abnormal_appendicular_skeleto0.74977266
86MP0003186_abnormal_redox_activity0.74799164
87MP0002092_abnormal_eye_morphology0.74383395
88MP0002102_abnormal_ear_morphology0.71512101
89MP0000678_abnormal_parathyroid_gland0.71195374
90MP0003699_abnormal_female_reproductive0.70914955
91MP0003935_abnormal_craniofacial_develop0.70156690
92MP0001485_abnormal_pinna_reflex0.69224171
93MP0001119_abnormal_female_reproductive0.68573745
94MP0002161_abnormal_fertility/fecundity0.67562502
95MP0006036_abnormal_mitochondrial_physio0.66183752
96MP0010352_gastrointestinal_tract_polyps0.62883536
97MP0003122_maternal_imprinting0.61854636
98MP0003936_abnormal_reproductive_system0.61415628
99MP0002081_perinatal_lethality0.59812232
100MP0005253_abnormal_eye_physiology0.59679744

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.24098802
2Chromsome breakage (HP:0040012)4.21276050
3Reticulocytopenia (HP:0001896)3.98961042
4Septo-optic dysplasia (HP:0100842)3.78122348
5Abnormality of the labia minora (HP:0012880)3.68599672
6Colon cancer (HP:0003003)3.53356237
7Meckel diverticulum (HP:0002245)3.49929989
8Abnormality of chromosome stability (HP:0003220)3.49490133
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.34926701
10Abnormality of the ileum (HP:0001549)3.30802451
11Abnormal lung lobation (HP:0002101)3.09180332
12Birth length less than 3rd percentile (HP:0003561)3.02819036
13Abnormal number of erythroid precursors (HP:0012131)2.97604624
14Abnormality of cells of the erythroid lineage (HP:0012130)2.90896804
15Abnormality of the preputium (HP:0100587)2.71918515
16Duodenal stenosis (HP:0100867)2.69008851
17Small intestinal stenosis (HP:0012848)2.69008851
18Homocystinuria (HP:0002156)2.60663510
19Abnormality of homocysteine metabolism (HP:0010919)2.60663510
20Abnormality of the duodenum (HP:0002246)2.55595623
21Abnormal number of incisors (HP:0011064)2.55466628
22Triphalangeal thumb (HP:0001199)2.54759649
23Absent septum pellucidum (HP:0001331)2.54611300
24Nephroblastoma (Wilms tumor) (HP:0002667)2.52074692
25Embryonal renal neoplasm (HP:0011794)2.48804711
26Abnormality of the septum pellucidum (HP:0007375)2.43887315
27Ectopic kidney (HP:0000086)2.43744730
28Macrocytic anemia (HP:0001972)2.42651436
29Duplication of thumb phalanx (HP:0009942)2.35445649
30Absent radius (HP:0003974)2.31126312
31Esophageal atresia (HP:0002032)2.30751825
32Short hallux (HP:0010109)2.29334503
33Maternal diabetes (HP:0009800)2.29075544
34Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.27726092
35Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.24466304
36Hepatoblastoma (HP:0002884)2.24107171
37Acute necrotizing encephalopathy (HP:0006965)2.23871687
38Multiple enchondromatosis (HP:0005701)2.22110092
39Partial duplication of thumb phalanx (HP:0009944)2.21329093
40Absent thumb (HP:0009777)2.20868061
41Short middle phalanx of the 5th finger (HP:0004220)2.18791304
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.18261636
43Increased hepatocellular lipid droplets (HP:0006565)2.17819001
44Abnormality of the phalanges of the 5th finger (HP:0004213)2.16143564
45Pallor (HP:0000980)2.14389195
46Abnormality of cochlea (HP:0000375)2.14321967
47Aplasia involving forearm bones (HP:0009822)2.14135218
48Absent forearm bone (HP:0003953)2.14135218
49Acute encephalopathy (HP:0006846)2.12981204
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.12865931
51Cortical dysplasia (HP:0002539)2.12373514
52Rhabdomyosarcoma (HP:0002859)2.10699250
53Breast aplasia (HP:0100783)2.10288709
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.10219870
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09847330
56Abnormality of the carotid arteries (HP:0005344)2.08759223
57Premature ovarian failure (HP:0008209)2.07626136
58Pancreatic fibrosis (HP:0100732)2.05208477
59Bilateral microphthalmos (HP:0007633)2.04700213
60Intestinal atresia (HP:0011100)2.01777868
61Facial cleft (HP:0002006)2.01612111
62Optic nerve hypoplasia (HP:0000609)2.01202990
63Sloping forehead (HP:0000340)2.00703223
64Anophthalmia (HP:0000528)1.98769403
65Hyperglycinemia (HP:0002154)1.98126702
66Horseshoe kidney (HP:0000085)1.96344985
67Gastrointestinal atresia (HP:0002589)1.94858195
68Lipid accumulation in hepatocytes (HP:0006561)1.94067830
69Aplasia/Hypoplasia of the breasts (HP:0010311)1.93826465
70Median cleft lip (HP:0000161)1.92468332
71Increased nuchal translucency (HP:0010880)1.92260527
72Partial duplication of the phalanx of hand (HP:0009999)1.92240815
73Stenosis of the external auditory canal (HP:0000402)1.91793555
74Pancreatic islet-cell hyperplasia (HP:0004510)1.91454495
75Abnormality of sulfur amino acid metabolism (HP:0004339)1.91358703
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90925697
77Abnormality of DNA repair (HP:0003254)1.90923417
78Abnormality of the middle phalanges of the toes (HP:0010183)1.90398440
79Bifid tongue (HP:0010297)1.90124808
80Supernumerary spleens (HP:0009799)1.86640400
81Abnormality of abdominal situs (HP:0011620)1.85611158
82Abdominal situs inversus (HP:0003363)1.85611158
83Abnormal mitochondria in muscle tissue (HP:0008316)1.85523792
84Hypoplastic female external genitalia (HP:0012815)1.81810922
85Myelodysplasia (HP:0002863)1.81107791
86Holoprosencephaly (HP:0001360)1.78028646
87Short thumb (HP:0009778)1.77472578
88Neoplasm of the colon (HP:0100273)1.77117752
89Labial hypoplasia (HP:0000066)1.76576711
90Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76398159
91Tracheoesophageal fistula (HP:0002575)1.74986189
92Abnormality of serum amino acid levels (HP:0003112)1.74799384
93Choanal atresia (HP:0000453)1.73078551
94Clubbing of toes (HP:0100760)1.72685514
95Rib fusion (HP:0000902)1.72324015
96Chronic bronchitis (HP:0004469)1.71536083
97Abnormality of methionine metabolism (HP:0010901)1.71311549
98Abnormality of reticulocytes (HP:0004312)1.66363885
99Progressive macrocephaly (HP:0004481)1.65333015
100Hypoplasia of the pons (HP:0012110)1.64929860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.73147845
2TTK3.77839773
3BUB13.59301146
4TNIK3.52673981
5PLK43.17437710
6ZAK2.93226637
7SRPK12.68623158
8PBK2.54565962
9BRSK22.54150869
10MKNK22.40967441
11PLK32.38035764
12NME12.28858845
13WEE12.26945856
14MKNK12.25379610
15VRK11.98435961
16TSSK61.93021489
17VRK21.91645914
18WNK31.85153512
19PLK11.75664368
20STK161.75568121
21NEK11.61160189
22NEK21.59970082
23DYRK31.58601716
24NUAK11.56539761
25ERBB41.53881549
26CHEK21.53735982
27BMPR1B1.46380354
28MST41.38578119
29CDK191.38394969
30ATR1.18307532
31MAP3K101.18301675
32DYRK21.17854821
33STK38L1.17380739
34STK31.16784648
35AURKB1.13041356
36NLK1.09608946
37EIF2AK11.08740909
38TAF11.05772450
39PLK21.03582091
40TLK11.00123422
41BRSK10.99657559
42ACVR1B0.95104563
43ATM0.94789035
44ALK0.94712716
45CHEK10.94598306
46CLK10.93644801
47FGFR10.91472181
48LATS10.87647167
49TRIM280.82564522
50EIF2AK30.82516802
51BRD40.81570244
52FLT30.80443205
53FGFR20.76874128
54LATS20.75580765
55PINK10.75504174
56CAMK1D0.74682938
57PASK0.73035797
58CDK10.71101519
59AURKA0.70792695
60TEC0.67810452
61BMX0.67354662
62STK40.67247505
63CDK20.66244535
64CAMK1G0.65847981
65CSNK1E0.64684783
66CDK70.63028932
67DMPK0.59273257
68MAP3K40.58191478
69GRK10.57118437
70CSNK2A20.55524972
71CSNK1G10.54667193
72STK240.52878569
73CSNK2A10.52032014
74CDK120.51744972
75MAP3K80.49597501
76PRKDC0.49172664
77TGFBR10.48476078
78BCR0.46109032
79TYRO30.42736665
80CDK30.40624732
81EPHA40.39528401
82PIM10.38529652
83EIF2AK20.38419209
84GSK3B0.36009435
85RPS6KA50.35712965
86NME20.34419640
87PAK10.33117610
88OBSCN0.32086326
89OXSR10.31913743
90CSNK1A10.31167621
91RAF10.30726037
92CSNK1G20.30349977
93PNCK0.29778116
94MAPK140.27066122
95TIE10.26678215
96MAP3K90.25631455
97NTRK30.23666250
98WNK10.23539009
99DYRK1A0.23515619
100WNK40.22428978

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.73746207
2DNA replication_Homo sapiens_hsa030303.66694891
3Homologous recombination_Homo sapiens_hsa034403.38575121
4Ribosome_Homo sapiens_hsa030103.32885781
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20410764
6RNA polymerase_Homo sapiens_hsa030202.95090679
7One carbon pool by folate_Homo sapiens_hsa006702.64637655
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58341495
9Spliceosome_Homo sapiens_hsa030402.56808347
10RNA transport_Homo sapiens_hsa030132.53675559
11Fanconi anemia pathway_Homo sapiens_hsa034602.46167421
12Non-homologous end-joining_Homo sapiens_hsa034502.17941108
13Cell cycle_Homo sapiens_hsa041102.14242922
14RNA degradation_Homo sapiens_hsa030182.07651939
15Proteasome_Homo sapiens_hsa030502.06944664
16Oxidative phosphorylation_Homo sapiens_hsa001902.04193517
17Nucleotide excision repair_Homo sapiens_hsa034202.03578590
18Basal transcription factors_Homo sapiens_hsa030221.99769036
19Base excision repair_Homo sapiens_hsa034101.98591779
20Parkinsons disease_Homo sapiens_hsa050121.90652640
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.84092287
22Selenocompound metabolism_Homo sapiens_hsa004501.73724335
23Protein export_Homo sapiens_hsa030601.70301774
24Huntingtons disease_Homo sapiens_hsa050161.62484029
25mRNA surveillance pathway_Homo sapiens_hsa030151.59456364
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45433634
27Steroid biosynthesis_Homo sapiens_hsa001001.41360620
28Pyrimidine metabolism_Homo sapiens_hsa002401.37313029
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36297004
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35324774
31Pyruvate metabolism_Homo sapiens_hsa006201.24370917
32Purine metabolism_Homo sapiens_hsa002301.20512425
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18686197
34Olfactory transduction_Homo sapiens_hsa047401.11743932
35Vitamin B6 metabolism_Homo sapiens_hsa007501.11372124
36Basal cell carcinoma_Homo sapiens_hsa052171.09579501
37Alzheimers disease_Homo sapiens_hsa050101.09057217
38Oocyte meiosis_Homo sapiens_hsa041141.07871920
39Biosynthesis of amino acids_Homo sapiens_hsa012300.97952172
40Vitamin digestion and absorption_Homo sapiens_hsa049770.97939868
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94404343
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94049004
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93916117
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91238165
45Propanoate metabolism_Homo sapiens_hsa006400.91048437
46Cardiac muscle contraction_Homo sapiens_hsa042600.90846569
47Hedgehog signaling pathway_Homo sapiens_hsa043400.84620659
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83330418
49p53 signaling pathway_Homo sapiens_hsa041150.82343635
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81064342
51Wnt signaling pathway_Homo sapiens_hsa043100.78614106
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75175890
53Retinol metabolism_Homo sapiens_hsa008300.73628166
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72611350
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72406371
56Butanoate metabolism_Homo sapiens_hsa006500.72358200
57TGF-beta signaling pathway_Homo sapiens_hsa043500.72082982
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69750369
59Lysine degradation_Homo sapiens_hsa003100.67733143
60Hippo signaling pathway_Homo sapiens_hsa043900.65307344
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63566685
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61762681
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59530393
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59407018
65Metabolic pathways_Homo sapiens_hsa011000.58766435
66Glutathione metabolism_Homo sapiens_hsa004800.55094847
67Taste transduction_Homo sapiens_hsa047420.52155421
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51917892
69Adherens junction_Homo sapiens_hsa045200.50877251
70Carbon metabolism_Homo sapiens_hsa012000.50868511
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50240740
72Systemic lupus erythematosus_Homo sapiens_hsa053220.49938556
73Phototransduction_Homo sapiens_hsa047440.46381560
74MicroRNAs in cancer_Homo sapiens_hsa052060.45415041
75Nicotine addiction_Homo sapiens_hsa050330.44791480
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.44531876
77Nitrogen metabolism_Homo sapiens_hsa009100.42986118
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42495887
79Tight junction_Homo sapiens_hsa045300.41795485
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37925336
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37704698
82Arginine and proline metabolism_Homo sapiens_hsa003300.36536303
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36493372
84Alcoholism_Homo sapiens_hsa050340.36065714
85Thyroid cancer_Homo sapiens_hsa052160.34366336
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31774375
87Chemical carcinogenesis_Homo sapiens_hsa052040.31548340
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29507998
89Fatty acid elongation_Homo sapiens_hsa000620.29058334
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26717088
91Fatty acid metabolism_Homo sapiens_hsa012120.22330045
92Folate biosynthesis_Homo sapiens_hsa007900.21911504
93Fat digestion and absorption_Homo sapiens_hsa049750.20573060
94Fatty acid degradation_Homo sapiens_hsa000710.19494268
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18510343
96Tryptophan metabolism_Homo sapiens_hsa003800.18250091
97Caffeine metabolism_Homo sapiens_hsa002320.17799708
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17322363
99Tyrosine metabolism_Homo sapiens_hsa003500.17255795
100Melanoma_Homo sapiens_hsa052180.16199774

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »