OR7E13P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tooth mineralization (GO:0034505)9.49614389
2detection of chemical stimulus involved in sensory perception of smell (GO:0050911)8.54764268
3negative regulation of catenin import into nucleus (GO:0035414)7.14880854
4centriole replication (GO:0007099)6.81816030
5peptidyl-tyrosine autophosphorylation (GO:0038083)6.79120224
6negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)6.59167738
7negative regulation of T-helper cell differentiation (GO:0045623)6.59167738
8behavioral response to ethanol (GO:0048149)6.57165662
9positive regulation of mitochondrial fission (GO:0090141)6.44399083
10activation of protein kinase A activity (GO:0034199)6.32419023
11protein K11-linked deubiquitination (GO:0035871)6.24089098
12positive regulation of T-helper 1 type immune response (GO:0002827)6.16548651
13positive regulation of protein sumoylation (GO:0033235)6.13606283
14synaptic transmission, dopaminergic (GO:0001963)5.91868378
15regulation of T-helper 1 cell differentiation (GO:0045625)5.91178483
16righting reflex (GO:0060013)5.82738543
17pentose-phosphate shunt (GO:0006098)5.72009069
18locomotory exploration behavior (GO:0035641)5.62194651
19cAMP biosynthetic process (GO:0006171)5.62039716
20regulation of T-helper 2 cell differentiation (GO:0045628)5.61521371
21seminiferous tubule development (GO:0072520)5.54518247
22positive regulation of RNA splicing (GO:0033120)5.53586015
23dendritic spine morphogenesis (GO:0060997)5.47475431
24detection of chemical stimulus involved in sensory perception (GO:0050907)5.36635933
25negative regulation of type 2 immune response (GO:0002829)5.30592194
26NADPH regeneration (GO:0006740)5.28042950
27regulation of corticosteroid hormone secretion (GO:2000846)5.27925967
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.16266264
29chemosensory behavior (GO:0007635)5.08466573
30parturition (GO:0007567)5.05627696
31negative regulation of alpha-beta T cell differentiation (GO:0046639)5.04622483
32alanine transport (GO:0032328)4.89940591
33sequestering of extracellular ligand from receptor (GO:0035581)4.80697966
34centriole assembly (GO:0098534)4.78103992
35retina layer formation (GO:0010842)4.77130325
36regulation of dendritic cell antigen processing and presentation (GO:0002604)4.63447680
37enteric nervous system development (GO:0048484)4.60848217
38arachidonic acid secretion (GO:0050482)4.50736296
39icosanoid secretion (GO:0032309)4.50736296
40negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.50724453
41centrosome duplication (GO:0051298)4.48744671
42regulation of mitochondrial fission (GO:0090140)4.48394089
43regulation of T-helper 1 type immune response (GO:0002825)4.41973718
44regulation of glucocorticoid secretion (GO:2000849)4.38981511
45glucose catabolic process (GO:0006007)4.31486793
46L-amino acid import (GO:0043092)4.15288030
47chaperone-mediated protein transport (GO:0072321)4.13063331
48positive regulation of mast cell degranulation (GO:0043306)4.08206212
49positive regulation of mast cell activation involved in immune response (GO:0033008)4.08206212
50behavioral response to cocaine (GO:0048148)3.98690417
51hypothalamus development (GO:0021854)3.97891757
52Sertoli cell development (GO:0060009)3.97431409
53positive regulation of protein targeting to membrane (GO:0090314)3.90836601
54negative regulation of catecholamine secretion (GO:0033604)3.90729338
55negative regulation of astrocyte differentiation (GO:0048712)3.82455461
56icosanoid transport (GO:0071715)3.79974097
57fatty acid derivative transport (GO:1901571)3.79974097
58detection of chemical stimulus (GO:0009593)3.78583035
59endothelial cell differentiation (GO:0045446)3.74567591
60regulation of protein sumoylation (GO:0033233)3.71173180
61endocrine hormone secretion (GO:0060986)3.67694982
62heterotypic cell-cell adhesion (GO:0034113)3.65151624
63tachykinin receptor signaling pathway (GO:0007217)3.64598729
64nerve growth factor signaling pathway (GO:0038180)3.60469881
65exploration behavior (GO:0035640)3.53301319
66regulation of steroid hormone secretion (GO:2000831)3.53226846
67basic amino acid transport (GO:0015802)3.52776754
68cytokine production involved in immune response (GO:0002367)3.48246555
69regulation of voltage-gated calcium channel activity (GO:1901385)3.45511998
70neural tube formation (GO:0001841)3.44666267
71phosphatidylserine acyl-chain remodeling (GO:0036150)3.42962422
72negative regulation of glial cell differentiation (GO:0045686)3.42645869
73cellular response to glucagon stimulus (GO:0071377)3.38806019
74positive regulation of mast cell activation (GO:0033005)3.35950362
75regulation of vesicle fusion (GO:0031338)3.35110271
76mitochondrial fusion (GO:0008053)3.34039862
77embryonic body morphogenesis (GO:0010172)3.30847410
78neuronal ion channel clustering (GO:0045161)3.21486249
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21411066
80positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.21333238
81nephron tubule morphogenesis (GO:0072078)3.20291010
82nephron epithelium morphogenesis (GO:0072088)3.20291010
83pre-miRNA processing (GO:0031054)3.19289739
84ribosomal small subunit biogenesis (GO:0042274)3.19100393
85positive regulation of membrane potential (GO:0045838)3.17109183
86monoamine transport (GO:0015844)3.15760627
87regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.14879406
88regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.14879406
89body morphogenesis (GO:0010171)3.13952167
90phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.13163359
91phosphatidylinositol acyl-chain remodeling (GO:0036149)3.08433421
92regulation of feeding behavior (GO:0060259)3.02245822
93positive regulation of T-helper cell differentiation (GO:0045624)3.00459592
94positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.00039508
95embryonic digestive tract morphogenesis (GO:0048557)2.96943729
96L-serine transport (GO:0015825)2.96026036
97positive regulation of antigen processing and presentation (GO:0002579)2.91607090
98regulation of protein targeting to membrane (GO:0090313)2.90908378
99protein localization to synapse (GO:0035418)2.90231254
100reflex (GO:0060004)2.88945242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.51927527
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.67837343
3EZH2_22144423_ChIP-Seq_EOC_Human4.83011154
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.33839924
5AR_21572438_ChIP-Seq_LNCaP_Human3.24017290
6VDR_22108803_ChIP-Seq_LS180_Human2.87892640
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.55282476
8RNF2_27304074_Chip-Seq_ESCs_Mouse2.32785135
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.19184618
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.12961871
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.07277947
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06354250
13IGF1R_20145208_ChIP-Seq_DFB_Human2.04597467
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03751997
15TP53_16413492_ChIP-PET_HCT116_Human2.01042893
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97866411
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.97550472
18GBX2_23144817_ChIP-Seq_PC3_Human1.97307424
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.97169626
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85061233
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84527959
22REST_21632747_ChIP-Seq_MESCs_Mouse1.83155286
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69331191
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65570427
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65570427
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60162213
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59042117
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54342571
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49533344
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.49251558
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48450044
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48436015
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47081934
34RNF2_27304074_Chip-Seq_NSC_Mouse1.46596692
35YY1_22570637_ChIP-Seq_MALME-3M_Human1.44678391
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44375339
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39311264
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38528952
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34425762
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29013131
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28804661
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28804661
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28577483
44CBP_20019798_ChIP-Seq_JUKART_Human1.28344529
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28344529
46ER_23166858_ChIP-Seq_MCF-7_Human1.28311101
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.27047099
48ZNF274_21170338_ChIP-Seq_K562_Hela1.25919299
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25164697
50KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23874983
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.21536586
52SMAD3_21741376_ChIP-Seq_HESCs_Human1.21219873
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20897191
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20581606
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16821872
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15373306
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.12820150
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.09844502
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08312579
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.07772434
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06106673
62DROSHA_22980978_ChIP-Seq_HELA_Human1.04779382
63CTCF_27219007_Chip-Seq_Bcells_Human1.04744162
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04222871
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04117426
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.02798626
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01181669
68EGR1_19032775_ChIP-ChIP_M12_Human1.00120596
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99980751
70CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98195968
71SMAD4_21741376_ChIP-Seq_HESCs_Human0.97879741
72KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97289540
73RXR_22108803_ChIP-Seq_LS180_Human0.96715035
74SMAD4_21741376_ChIP-Seq_EPCs_Human0.96446828
75PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95728399
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94207298
77BCAT_22108803_ChIP-Seq_LS180_Human0.93660526
78HNFA_21074721_ChIP-Seq_CACO-2_Human0.93397141
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92893316
80STAT3_23295773_ChIP-Seq_U87_Human0.91111999
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91034790
82TBL1_22424771_ChIP-Seq_293T_Human0.90973669
83NANOG_20526341_ChIP-Seq_ESCs_Human0.90931430
84SOX2_18555785_Chip-Seq_ESCs_Mouse0.89336200
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89219020
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.88070564
87P53_22387025_ChIP-Seq_ESCs_Mouse0.87497361
88CMYC_18555785_Chip-Seq_ESCs_Mouse0.87282012
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.86748926
90SMAD4_21799915_ChIP-Seq_A2780_Human0.85431705
91TCF4_22108803_ChIP-Seq_LS180_Human0.84984266
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.84888714
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.84343026
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82807909
95ETV1_20927104_ChIP-Seq_GIST48_Human0.82510744
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.81400734
97KLF4_18555785_Chip-Seq_ESCs_Mouse0.80082743
98AR_25329375_ChIP-Seq_VCAP_Human0.78501631
99EGR1_19374776_ChIP-ChIP_THP-1_Human0.77975038
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77838494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo8.37339592
2MP0008961_abnormal_basal_metabolism6.60226024
3MP0004133_heterotaxia4.31751536
4MP0004130_abnormal_muscle_cell3.96372547
5MP0003011_delayed_dark_adaptation3.07250174
6MP0005646_abnormal_pituitary_gland2.71667808
7MP0009053_abnormal_anal_canal2.35076812
8MP0006072_abnormal_retinal_apoptosis2.22367318
9MP0003252_abnormal_bile_duct2.18785551
10MP0002234_abnormal_pharynx_morphology2.10829730
11MP0000537_abnormal_urethra_morphology2.08763399
12MP0001905_abnormal_dopamine_level2.04353093
13MP0001188_hyperpigmentation2.03409800
14MP0003890_abnormal_embryonic-extraembry1.98197023
15MP0003787_abnormal_imprinting1.89569774
16MP0004264_abnormal_extraembryonic_tissu1.85474256
17MP0006276_abnormal_autonomic_nervous1.83751142
18MP0005448_abnormal_energy_balance1.78019408
19MP0005253_abnormal_eye_physiology1.76321692
20MP0008569_lethality_at_weaning1.69701970
21MP0005379_endocrine/exocrine_gland_phen1.64745902
22MP0002751_abnormal_autonomic_nervous1.62241447
23MP0002160_abnormal_reproductive_system1.60896771
24MP0009379_abnormal_foot_pigmentation1.57293653
25MP0002928_abnormal_bile_duct1.54816841
26MP0003806_abnormal_nucleotide_metabolis1.49859909
27MP0001299_abnormal_eye_distance/1.45328855
28MP0008789_abnormal_olfactory_epithelium1.44243943
29MP0003119_abnormal_digestive_system1.41963386
30MP0002184_abnormal_innervation1.37832247
31MP0001270_distended_abdomen1.37527619
32MP0002108_abnormal_muscle_morphology1.36946242
33MP0003121_genomic_imprinting1.34699977
34MP0000631_abnormal_neuroendocrine_gland1.33056851
35MP0002572_abnormal_emotion/affect_behav1.32042780
36MP0002909_abnormal_adrenal_gland1.31914634
37MP0002653_abnormal_ependyma_morphology1.31009891
38MP0001542_abnormal_bone_strength1.27889154
39MP0005365_abnormal_bile_salt1.23340401
40MP0005645_abnormal_hypothalamus_physiol1.22831570
41MP0005394_taste/olfaction_phenotype1.22384268
42MP0005499_abnormal_olfactory_system1.22384268
43MP0003123_paternal_imprinting1.21672727
44MP0005220_abnormal_exocrine_pancreas1.20088706
45MP0003329_amyloid_beta_deposits1.18963462
46MP0004858_abnormal_nervous_system1.16757779
47MP0002638_abnormal_pupillary_reflex1.11789175
48MP0003136_yellow_coat_color1.07617252
49MP0004145_abnormal_muscle_electrophysio1.06742203
50MP0002102_abnormal_ear_morphology1.05761658
51MP0005257_abnormal_intraocular_pressure1.05322074
52MP0002882_abnormal_neuron_morphology1.04513898
53MP0000639_abnormal_adrenal_gland1.04312524
54MP0006292_abnormal_olfactory_placode0.98905551
55MP0004272_abnormal_basement_membrane0.97718832
56MP0003880_abnormal_central_pattern0.95060296
57MP0000049_abnormal_middle_ear0.93741934
58MP0002734_abnormal_mechanical_nocicepti0.92882289
59MP0001529_abnormal_vocalization0.92861127
60MP0000604_amyloidosis0.92432068
61MP0005551_abnormal_eye_electrophysiolog0.88700186
62MP0002752_abnormal_somatic_nervous0.87369765
63MP0005391_vision/eye_phenotype0.87108837
64MP0009745_abnormal_behavioral_response0.83826921
65MP0000778_abnormal_nervous_system0.79819897
66MP0001944_abnormal_pancreas_morphology0.78521510
67MP0002063_abnormal_learning/memory/cond0.76315658
68MP0003938_abnormal_ear_development0.75656068
69MP0002282_abnormal_trachea_morphology0.75353648
70MP0003953_abnormal_hormone_level0.73216555
71MP0002822_catalepsy0.72842567
72MP0005369_muscle_phenotype0.72303780
73MP0002078_abnormal_glucose_homeostasis0.69192870
74MP0000955_abnormal_spinal_cord0.68941625
75MP0001970_abnormal_pain_threshold0.68910270
76MP0005195_abnormal_posterior_eye0.68488304
77MP0003718_maternal_effect0.68106366
78MP0003635_abnormal_synaptic_transmissio0.67590579
79MP0002233_abnormal_nose_morphology0.67549779
80MP0005165_increased_susceptibility_to0.67427941
81MP0002693_abnormal_pancreas_physiology0.67335977
82MP0002272_abnormal_nervous_system0.66502014
83MP0005389_reproductive_system_phenotype0.65378885
84MP0009046_muscle_twitch0.64876190
85MP0005408_hypopigmentation0.63481982
86MP0002229_neurodegeneration0.63368037
87MP0003937_abnormal_limbs/digits/tail_de0.62845914
88MP0004134_abnormal_chest_morphology0.62206615
89MP0002066_abnormal_motor_capabilities/c0.61342588
90MP0001175_abnormal_lung_morphology0.61132068
91MP0008875_abnormal_xenobiotic_pharmacok0.60076923
92MP0009764_decreased_sensitivity_to0.59950955
93MP0005085_abnormal_gallbladder_physiolo0.58712830
94MP0002067_abnormal_sensory_capabilities0.57928387
95MP0000759_abnormal_skeletal_muscle0.55554487
96MP0010386_abnormal_urinary_bladder0.54554034
97MP0002109_abnormal_limb_morphology0.54371863
98MP0003861_abnormal_nervous_system0.54011656
99MP0002152_abnormal_brain_morphology0.53818710
100MP0003942_abnormal_urinary_system0.52258736

Predicted human phenotypes

RankGene SetZ-score
1Patent foramen ovale (HP:0001655)6.78516080
2Abnormal hair whorl (HP:0010721)6.75851342
3Bile duct proliferation (HP:0001408)6.67530942
4Abnormal biliary tract physiology (HP:0012439)6.67530942
5Overgrowth (HP:0001548)5.97960916
6Amelogenesis imperfecta (HP:0000705)5.95330999
7Abnormality of the right ventricle (HP:0001707)5.69049311
8Abnormality of calcium-phosphate metabolism (HP:0100530)5.40348953
9Osteomalacia (HP:0002749)5.32125861
10Abnormality of renal resorption (HP:0011038)5.19285035
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.08477990
12Lip pit (HP:0100267)4.78198067
13Abnormality of dental color (HP:0011073)4.57151428
14Abnormality of the dental pulp (HP:0006479)4.25309712
15Depressed nasal tip (HP:0000437)4.15795328
16Molar tooth sign on MRI (HP:0002419)3.60029243
17Abnormality of midbrain morphology (HP:0002418)3.60029243
18Hypoplastic pelvis (HP:0008839)3.56583838
19Polyuria (HP:0000103)3.37080373
20Morphological abnormality of the middle ear (HP:0008609)3.15644194
21Abnormality of the neuromuscular junction (HP:0003398)3.10254699
22Fatigable weakness (HP:0003473)3.10254699
233-Methylglutaconic aciduria (HP:0003535)3.08225962
24Abnormal urine output (HP:0012590)3.08074031
25Spastic tetraparesis (HP:0001285)3.05071087
26Chronic bronchitis (HP:0004469)2.99415734
27Abnormality of renal excretion (HP:0011036)2.94822685
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.92341924
29Decreased muscle mass (HP:0003199)2.90115801
30Abnormality of the nasal septum (HP:0000419)2.87321738
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.83021598
32Abnormal respiratory motile cilium physiology (HP:0012261)2.82138034
33Gonadotropin excess (HP:0000837)2.75597331
34Abolished electroretinogram (ERG) (HP:0000550)2.65522985
35Abnormality of the distal phalanges of the toes (HP:0010182)2.57906121
36Cortical dysplasia (HP:0002539)2.57063036
37Rhinitis (HP:0012384)2.53026732
38Abnormality of the umbilical cord (HP:0010881)2.47203961
39Wide nose (HP:0000445)2.34125322
40Short nail (HP:0001799)2.33213083
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.30517341
42Short 1st metacarpal (HP:0010034)2.30517341
43Submucous cleft hard palate (HP:0000176)2.30283619
44Abnormality of the middle phalanges of the toes (HP:0010183)2.24986151
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.23041565
46Progressive microcephaly (HP:0000253)2.22933139
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.18058554
48Anosmia (HP:0000458)2.14388525
49Fused cervical vertebrae (HP:0002949)2.12936431
50Posterior subcapsular cataract (HP:0007787)2.11999564
51Nephrocalcinosis (HP:0000121)2.11258897
52Abnormal finger flexion creases (HP:0006143)2.10584122
53Abnormality of the 1st metacarpal (HP:0010009)2.07789567
54Humeroradial synostosis (HP:0003041)2.07321122
55Synostosis involving the elbow (HP:0003938)2.07321122
56Rib fusion (HP:0000902)2.06886745
57Absent phalangeal crease (HP:0006109)1.99267596
58Round ear (HP:0100830)1.96566240
59Rocker bottom foot (HP:0001838)1.95612846
60Congenital malformation of the right heart (HP:0011723)1.95046121
61Double outlet right ventricle (HP:0001719)1.95046121
62Tarsal synostosis (HP:0008368)1.95043390
63Sparse lateral eyebrow (HP:0005338)1.92037230
64Severe global developmental delay (HP:0011344)1.90980119
65Symphalangism affecting the phalanges of the hand (HP:0009773)1.88212603
66Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.86745528
67Short 5th finger (HP:0009237)1.86132099
68Synostosis involving bones of the lower limbs (HP:0009138)1.82948195
69Synostosis involving bones of the feet (HP:0009140)1.82948195
70Adrenal hypoplasia (HP:0000835)1.82913256
71Pancreatic islet-cell hyperplasia (HP:0004510)1.81905909
72Small for gestational age (HP:0001518)1.81035361
73Drooling (HP:0002307)1.80682634
74Prolonged QT interval (HP:0001657)1.79937724
75Mildly elevated creatine phosphokinase (HP:0008180)1.79353476
76Hyperphosphaturia (HP:0003109)1.77974774
77Abnormal rod and cone electroretinograms (HP:0008323)1.75408271
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74521405
79Myelomeningocele (HP:0002475)1.74177946
80Hypophosphatemic rickets (HP:0004912)1.73606918
81Deep palmar crease (HP:0006191)1.72695663
82Hypoparathyroidism (HP:0000829)1.71034836
83Abnormality of the fovea (HP:0000493)1.69870812
84Long foot (HP:0001833)1.69246733
85Short hallux (HP:0010109)1.67533476
86Oculomotor apraxia (HP:0000657)1.67312012
87Abnormal urine phosphate concentration (HP:0012599)1.66628984
88Excessive salivation (HP:0003781)1.66163520
89Short humerus (HP:0005792)1.66092648
90Nephronophthisis (HP:0000090)1.65853448
91Cystic hygroma (HP:0000476)1.65429643
92Absent septum pellucidum (HP:0001331)1.64245271
93Lipoatrophy (HP:0100578)1.63492022
94Slender long bone (HP:0003100)1.63244949
95Gonadal dysgenesis (HP:0000133)1.63204221
96Primary amenorrhea (HP:0000786)1.63022583
97Microretrognathia (HP:0000308)1.61756431
98Short phalanx of the thumb (HP:0009660)1.61692021
99Thyroiditis (HP:0100646)1.61283342
100Hypoplasia of dental enamel (HP:0006297)1.59210084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK7.97237366
2NTRK26.57675498
3AKT32.99210705
4PINK12.16849399
5WNK32.00404714
6BMPR1B10.3428072
7MAP4K11.93524703
8MAP3K41.88787562
9BLK1.64737595
10STK31.53871288
11CAMK1D1.37079696
12BRAF1.32322714
13MAP2K71.32111217
14CAMK1G1.23274933
15ADRBK21.22339560
16ICK1.16180203
17SGK2231.14019934
18SGK4941.14019934
19WNK41.09406307
20NTRK31.08199180
21CDC42BPA0.91464027
22OBSCN0.88832161
23ARAF0.88757462
24TYRO30.82791057
25DYRK20.80289498
26RIPK40.69855470
27PAK30.68978667
28PRKCQ0.68668074
29BMPR20.66387614
30CDK50.64715452
31GRK10.62118692
32MINK10.60767402
33STK390.60619419
34PRKCG0.56857776
35FRK0.55602531
36NTRK10.53564921
37SGK20.52920440
38MYLK0.52246972
39DYRK30.48180901
40TNK20.47995901
41INSRR0.47599728
42PRKACB0.46172845
43PNCK0.45839971
44FYN0.44003131
45TAOK30.43815718
46MATK0.43326625
47ROCK20.39462557
48MAP3K90.39089926
49SRC0.38513901
50PRKACA0.37631007
51MAPK130.36874160
52STK110.36464995
53PRKAA10.34746402
54RPS6KA60.33067007
55UHMK10.32083800
56ABL10.31823514
57TIE10.31289561
58RPS6KC10.31245035
59RPS6KL10.31245035
60SGK30.30802752
61EPHB20.30362775
62CAMK10.30245874
63OXSR10.28594312
64EPHA40.28395778
65RPS6KA10.28216422
66BRSK10.27245434
67PRKCD0.27176191
68CAMK2D0.27145454
69PRKACG0.27138463
70ERBB20.26642106
71PLK40.25757737
72CAMK40.24799395
73STK160.24555057
74HIPK20.23777302
75ADRBK10.23569409
76CSNK1D0.23510645
77ROCK10.23194970
78CDK30.22291922
79CAMKK10.18895165
80TLK10.17175943
81FGFR10.16931951
82CAMK2A0.16889191
83MAPK150.16306033
84CSNK1A10.16134368
85PIM20.16024507
86AKT10.14518755
87PRKCA0.13419909
88MAP2K40.12589523
89MAPK110.12390229
90PIK3CA0.11621326
91NEK20.10991124
92CDK190.10714013
93GRK70.10512467
94INSR0.10436163
95SCYL20.10415049
96RPS6KB10.09773998
97NEK90.09182656
98PRKG10.08951057
99MOS0.08335152
100NME20.08267680

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.27686416
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.25907845
3Ovarian steroidogenesis_Homo sapiens_hsa049132.66140428
4Pentose phosphate pathway_Homo sapiens_hsa000302.54230204
5Sulfur metabolism_Homo sapiens_hsa009202.49906568
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47309965
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41330154
8Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.39887102
9Linoleic acid metabolism_Homo sapiens_hsa005912.38209661
10Collecting duct acid secretion_Homo sapiens_hsa049662.17357395
11Circadian entrainment_Homo sapiens_hsa047132.01695461
12Glutamatergic synapse_Homo sapiens_hsa047241.99826680
13Synaptic vesicle cycle_Homo sapiens_hsa047211.99500389
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.92202156
15Bile secretion_Homo sapiens_hsa049761.90105767
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.89542125
17Thyroid hormone synthesis_Homo sapiens_hsa049181.87074584
18Sulfur relay system_Homo sapiens_hsa041221.80248992
19Vibrio cholerae infection_Homo sapiens_hsa051101.69699550
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68284244
21Gastric acid secretion_Homo sapiens_hsa049711.63237483
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.63076166
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62122104
24Salivary secretion_Homo sapiens_hsa049701.61737295
25Pancreatic secretion_Homo sapiens_hsa049721.60225368
26GABAergic synapse_Homo sapiens_hsa047271.59761211
27Cocaine addiction_Homo sapiens_hsa050301.58424223
28Basal cell carcinoma_Homo sapiens_hsa052171.57666606
29Insulin secretion_Homo sapiens_hsa049111.56271219
30Morphine addiction_Homo sapiens_hsa050321.55547323
31Fat digestion and absorption_Homo sapiens_hsa049751.54016696
32Oxidative phosphorylation_Homo sapiens_hsa001901.52775810
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51074540
34Dorso-ventral axis formation_Homo sapiens_hsa043201.43740235
35Dilated cardiomyopathy_Homo sapiens_hsa054141.41059289
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36894360
37Arachidonic acid metabolism_Homo sapiens_hsa005901.36020565
38Cholinergic synapse_Homo sapiens_hsa047251.31332621
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26127948
40Taste transduction_Homo sapiens_hsa047421.24743975
41Calcium signaling pathway_Homo sapiens_hsa040201.22449083
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21633444
43Parkinsons disease_Homo sapiens_hsa050121.21493518
44Gap junction_Homo sapiens_hsa045401.16607388
45Serotonergic synapse_Homo sapiens_hsa047261.13581556
46Amphetamine addiction_Homo sapiens_hsa050311.13346059
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12457670
48Melanogenesis_Homo sapiens_hsa049161.10164588
49GnRH signaling pathway_Homo sapiens_hsa049120.97149851
50Ether lipid metabolism_Homo sapiens_hsa005650.96009873
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95101694
52Endometrial cancer_Homo sapiens_hsa052130.91036821
53Nicotine addiction_Homo sapiens_hsa050330.88803639
54Long-term depression_Homo sapiens_hsa047300.88422280
55Oxytocin signaling pathway_Homo sapiens_hsa049210.85615104
56Glucagon signaling pathway_Homo sapiens_hsa049220.79245690
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.78455325
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76381217
59Dopaminergic synapse_Homo sapiens_hsa047280.73729021
60Renal cell carcinoma_Homo sapiens_hsa052110.69804057
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68356093
62Alcoholism_Homo sapiens_hsa050340.67912501
63ECM-receptor interaction_Homo sapiens_hsa045120.67874774
64Mineral absorption_Homo sapiens_hsa049780.67733923
65Insulin signaling pathway_Homo sapiens_hsa049100.66885562
66Platelet activation_Homo sapiens_hsa046110.63623066
67Phototransduction_Homo sapiens_hsa047440.62536907
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60846996
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60218352
70Estrogen signaling pathway_Homo sapiens_hsa049150.59042860
71Protein export_Homo sapiens_hsa030600.58408862
72Huntingtons disease_Homo sapiens_hsa050160.58009364
73Retinol metabolism_Homo sapiens_hsa008300.56464259
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.53520150
75Biosynthesis of amino acids_Homo sapiens_hsa012300.53419467
76RNA degradation_Homo sapiens_hsa030180.53005926
77Circadian rhythm_Homo sapiens_hsa047100.52762545
78Notch signaling pathway_Homo sapiens_hsa043300.51335079
79Chemokine signaling pathway_Homo sapiens_hsa040620.51179870
80Colorectal cancer_Homo sapiens_hsa052100.50553665
81Hedgehog signaling pathway_Homo sapiens_hsa043400.48210408
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.46818994
83cAMP signaling pathway_Homo sapiens_hsa040240.46800743
84Alzheimers disease_Homo sapiens_hsa050100.44867692
85Hippo signaling pathway_Homo sapiens_hsa043900.44499532
86Ribosome_Homo sapiens_hsa030100.43621900
87Chemical carcinogenesis_Homo sapiens_hsa052040.41014522
88Long-term potentiation_Homo sapiens_hsa047200.40380708
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34467336
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.34026466
91Oocyte meiosis_Homo sapiens_hsa041140.32328016
92Rap1 signaling pathway_Homo sapiens_hsa040150.32087782
93Tyrosine metabolism_Homo sapiens_hsa003500.31597226
94Wnt signaling pathway_Homo sapiens_hsa043100.30215261
95Ras signaling pathway_Homo sapiens_hsa040140.28831951
96Pathways in cancer_Homo sapiens_hsa052000.27591809
97Rheumatoid arthritis_Homo sapiens_hsa053230.27584030
98Cardiac muscle contraction_Homo sapiens_hsa042600.26486772
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24883863
100Renin secretion_Homo sapiens_hsa049240.22458546

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