OR7E148P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.53602703
2positive regulation of gamma-delta T cell activation (GO:0046645)6.41098818
3kinetochore assembly (GO:0051382)5.80664455
4regulation of regulatory T cell differentiation (GO:0045589)5.47390436
5regulation of gamma-delta T cell differentiation (GO:0045586)5.39411110
6negative regulation of T cell apoptotic process (GO:0070233)5.32273539
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.24486326
8kinetochore organization (GO:0051383)5.08112656
9mitochondrion distribution (GO:0048311)5.00488243
10response to pheromone (GO:0019236)4.94454304
11positive regulation of protein homodimerization activity (GO:0090073)4.81392379
12regulation of gamma-delta T cell activation (GO:0046643)4.37108171
13cellular zinc ion homeostasis (GO:0006882)4.33925155
14platelet dense granule organization (GO:0060155)4.21185183
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19979476
16negative regulation by host of viral transcription (GO:0043922)4.14667653
17cytidine deamination (GO:0009972)4.08475174
18cytidine metabolic process (GO:0046087)4.08475174
19cytidine catabolic process (GO:0006216)4.08475174
20lymph node development (GO:0048535)4.01630027
21reciprocal meiotic recombination (GO:0007131)3.94234572
22reciprocal DNA recombination (GO:0035825)3.94234572
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.84159830
24zinc ion homeostasis (GO:0055069)3.78988343
25cell wall macromolecule catabolic process (GO:0016998)3.73993231
26pyrimidine ribonucleoside catabolic process (GO:0046133)3.73740558
27negative regulation of nitric oxide biosynthetic process (GO:0045019)3.67265009
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63023857
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63023857
30cellular response to interleukin-15 (GO:0071350)3.57246232
31phosphatidylinositol dephosphorylation (GO:0046856)3.56008770
32regulation of mitotic spindle checkpoint (GO:1903504)3.52533080
33regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.52533080
34regulation of activation of Janus kinase activity (GO:0010533)3.50960972
35positive regulation of granulocyte differentiation (GO:0030854)3.50110521
36RNA destabilization (GO:0050779)3.49421559
37pyrimidine nucleotide catabolic process (GO:0006244)3.48267517
38regulation of centriole replication (GO:0046599)3.46073581
39response to interferon-beta (GO:0035456)3.45639583
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.44356808
41tolerance induction (GO:0002507)3.42658495
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42153405
43negative regulation of lymphocyte apoptotic process (GO:0070229)3.41684690
44base-excision repair, AP site formation (GO:0006285)3.41411173
45regulation of T cell receptor signaling pathway (GO:0050856)3.41122424
46cellular response to zinc ion (GO:0071294)3.41114128
47xenobiotic catabolic process (GO:0042178)3.33242974
48rRNA modification (GO:0000154)3.28936630
49pseudouridine synthesis (GO:0001522)3.28044070
50rRNA methylation (GO:0031167)3.27491187
51phospholipid dephosphorylation (GO:0046839)3.27414995
52maturation of 5.8S rRNA (GO:0000460)3.27002441
53positive regulation of translational initiation (GO:0045948)3.26730626
54resolution of meiotic recombination intermediates (GO:0000712)3.24751010
55regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24386919
56protein neddylation (GO:0045116)3.19097735
57interferon-gamma production (GO:0032609)3.18986238
58regulation of chronic inflammatory response (GO:0002676)3.18157939
59ubiquinone biosynthetic process (GO:0006744)3.16182578
60regulation of lipoprotein particle clearance (GO:0010984)3.15455188
61GPI anchor metabolic process (GO:0006505)3.09196565
62negative regulation of meiotic cell cycle (GO:0051447)3.09056343
63neutrophil activation (GO:0042119)3.06091457
64negative regulation of meiosis (GO:0045835)3.05934295
65cell wall macromolecule metabolic process (GO:0044036)3.05606534
66negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.05536230
67ubiquinone metabolic process (GO:0006743)3.03569726
68cellular response to interferon-beta (GO:0035458)3.03447778
69positive regulation of humoral immune response (GO:0002922)2.97965388
70eosinophil chemotaxis (GO:0048245)2.97351193
71fucose catabolic process (GO:0019317)2.88908082
72L-fucose metabolic process (GO:0042354)2.88908082
73L-fucose catabolic process (GO:0042355)2.88908082
74positive regulation of cardiac muscle cell differentiation (GO:2000727)2.87249587
75GPI anchor biosynthetic process (GO:0006506)2.83502942
76regulation of natural killer cell mediated immunity (GO:0002715)2.82987336
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82987336
78response to interleukin-15 (GO:0070672)2.80921992
79positive regulation of T cell chemotaxis (GO:0010820)2.80331562
80regulation of T cell chemotaxis (GO:0010819)2.80331562
81mast cell degranulation (GO:0043303)2.76023240
82mast cell activation involved in immune response (GO:0002279)2.76023240
83regulation of non-canonical Wnt signaling pathway (GO:2000050)2.75592768
84DNA replication-dependent nucleosome assembly (GO:0006335)2.74989354
85DNA replication-dependent nucleosome organization (GO:0034723)2.74989354
86response to vitamin E (GO:0033197)2.74685072
87regulation of meiosis I (GO:0060631)2.72522300
88positive regulation of natural killer cell mediated immunity (GO:0002717)2.72519848
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72450410
90rRNA catabolic process (GO:0016075)2.72321756
91detection of bacterium (GO:0016045)2.70824396
92positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.70327569
93deoxyribonucleotide catabolic process (GO:0009264)2.68364881
94negative regulation of chemokine production (GO:0032682)2.65543412
95replication fork processing (GO:0031297)2.65497909
96embryonic viscerocranium morphogenesis (GO:0048703)2.65193624
97eosinophil migration (GO:0072677)2.64058882
98mitochondrion morphogenesis (GO:0070584)2.63211295
99positive regulation of calcium-mediated signaling (GO:0050850)2.61553876
100secondary heart field specification (GO:0003139)2.61543554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.38495333
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.23311287
3E2F7_22180533_ChIP-Seq_HELA_Human4.01843769
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80037054
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.67951907
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19872891
7VDR_22108803_ChIP-Seq_LS180_Human3.11966762
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.98084302
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.90481002
10MYC_18940864_ChIP-ChIP_HL60_Human2.89337529
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.89284349
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63781397
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.63391357
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.52198819
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32733529
16IGF1R_20145208_ChIP-Seq_DFB_Human2.20550228
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16003082
18ZNF274_21170338_ChIP-Seq_K562_Hela2.09174232
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06913618
20ELK1_19687146_ChIP-ChIP_HELA_Human2.05720467
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05382062
22EWS_26573619_Chip-Seq_HEK293_Human1.98597965
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97647116
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96384510
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86934899
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84450064
27PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.78838747
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77326542
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70500000
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64911454
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64622149
32GATA3_26560356_Chip-Seq_TH2_Human1.61218540
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60283949
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53520197
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50128377
36ER_23166858_ChIP-Seq_MCF-7_Human1.49993069
37VDR_23849224_ChIP-Seq_CD4+_Human1.47276653
38FOXP3_21729870_ChIP-Seq_TREG_Human1.47188847
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45417666
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42368913
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.41188054
42CBP_20019798_ChIP-Seq_JUKART_Human1.37387086
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37387086
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37052837
45MYB_26560356_Chip-Seq_TH2_Human1.35311836
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34590977
47TCF4_22108803_ChIP-Seq_LS180_Human1.33928498
48GATA3_27048872_Chip-Seq_THYMUS_Human1.33671365
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33623142
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28372021
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27121598
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.23782565
53RUNX_20019798_ChIP-Seq_JUKART_Human1.23033623
54TP53_22573176_ChIP-Seq_HFKS_Human1.20098462
55BCAT_22108803_ChIP-Seq_LS180_Human1.19227161
56TP53_16413492_ChIP-PET_HCT116_Human1.16133402
57GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.15473451
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15088756
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15074945
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13261576
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12041663
62GABP_19822575_ChIP-Seq_HepG2_Human1.11851186
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09532645
64FOXH1_21741376_ChIP-Seq_EPCs_Human1.07494608
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.06424041
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06424041
67AR_20517297_ChIP-Seq_VCAP_Human1.06032895
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06027815
69SOX2_19829295_ChIP-Seq_ESCs_Human1.04956611
70NANOG_19829295_ChIP-Seq_ESCs_Human1.04956611
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.03698771
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03295562
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.02707044
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02393112
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.02384134
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.01405437
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00631249
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99757400
79PRDM14_20953172_ChIP-Seq_ESCs_Human0.98588765
80NCOR_22424771_ChIP-Seq_293T_Human0.97187345
81IRF8_22096565_ChIP-ChIP_GC-B_Human0.94765317
82P300_19829295_ChIP-Seq_ESCs_Human0.93566245
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.92866246
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92381972
85MYB_26560356_Chip-Seq_TH1_Human0.90464023
86WT1_19549856_ChIP-ChIP_CCG9911_Human0.90397954
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89652849
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88689235
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87738664
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87063110
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87036003
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86754196
93FUS_26573619_Chip-Seq_HEK293_Human0.85850839
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85428857
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85188763
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84862797
97GATA3_26560356_Chip-Seq_TH1_Human0.83457190
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83086719
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82984554
100CEBPB_22108803_ChIP-Seq_LS180_Human0.82556376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.35581840
2MP0005671_abnormal_response_to4.35660778
3MP0003763_abnormal_thymus_physiology3.49991729
4MP0010094_abnormal_chromosome_stability3.24166136
5MP0002653_abnormal_ependyma_morphology3.12171396
6MP0006292_abnormal_olfactory_placode3.11480167
7MP0005174_abnormal_tail_pigmentation3.05382317
8MP0003646_muscle_fatigue2.65169507
9MP0005084_abnormal_gallbladder_morpholo2.32393609
10MP0005275_abnormal_skin_tensile2.26807674
11MP0001293_anophthalmia2.23645892
12MP0000015_abnormal_ear_pigmentation2.19243614
13MP0010368_abnormal_lymphatic_system2.16093003
14MP0000372_irregular_coat_pigmentation2.13447167
15MP0003111_abnormal_nucleus_morphology1.93686759
16MP0000427_abnormal_hair_cycle1.88281138
17MP0001188_hyperpigmentation1.83353734
18MP0003724_increased_susceptibility_to1.79051941
19MP0001919_abnormal_reproductive_system1.75525736
20MP0000371_diluted_coat_color1.74770391
21MP0005389_reproductive_system_phenotype1.72282596
22MP0004147_increased_porphyrin_level1.72167923
23MP0009333_abnormal_splenocyte_physiolog1.71755875
24MP0000751_myopathy1.67467283
25MP0005075_abnormal_melanosome_morpholog1.66217263
26MP0008872_abnormal_physiological_respon1.64226686
27MP0004043_abnormal_pH_regulation1.63870710
28MP0005670_abnormal_white_adipose1.60279872
29MP0008058_abnormal_DNA_repair1.57763939
30MP0003950_abnormal_plasma_membrane1.52860066
31MP0000383_abnormal_hair_follicle1.43122658
32MP0001986_abnormal_taste_sensitivity1.40889484
33MP0000703_abnormal_thymus_morphology1.38812362
34MP0005000_abnormal_immune_tolerance1.37204934
35MP0005464_abnormal_platelet_physiology1.35998139
36MP0008057_abnormal_DNA_replication1.34066468
37MP0002723_abnormal_immune_serum1.33904669
38MP0008438_abnormal_cutaneous_collagen1.33516790
39MP0004885_abnormal_endolymph1.32680830
40MP0002933_joint_inflammation1.29414782
41MP0003943_abnormal_hepatobiliary_system1.27583009
42MP0008877_abnormal_DNA_methylation1.24249338
43MP0003693_abnormal_embryo_hatching1.22590099
44MP0001819_abnormal_immune_cell1.21676266
45MP0001800_abnormal_humoral_immune1.16802210
46MP0002420_abnormal_adaptive_immunity1.15898749
47MP0001119_abnormal_female_reproductive1.12907553
48MP0000689_abnormal_spleen_morphology1.11249737
49MP0003077_abnormal_cell_cycle1.10805187
50MP0002736_abnormal_nociception_after1.10594524
51MP0001661_extended_life_span1.09248394
52MP0002398_abnormal_bone_marrow1.07800165
53MP0001542_abnormal_bone_strength1.07112027
54MP0000716_abnormal_immune_system1.05897149
55MP0010678_abnormal_skin_adnexa1.05560618
56MP0002722_abnormal_immune_system1.04552166
57MP0002938_white_spotting1.02141202
58MP0002405_respiratory_system_inflammati1.01907112
59MP0005646_abnormal_pituitary_gland0.97660285
60MP0004185_abnormal_adipocyte_glucose0.93410990
61MP0002210_abnormal_sex_determination0.92832351
62MP0001968_abnormal_touch/_nociception0.92759359
63MP0001243_abnormal_dermal_layer0.92187945
64MP0002429_abnormal_blood_cell0.91989016
65MP0002638_abnormal_pupillary_reflex0.91165012
66MP0005666_abnormal_adipose_tissue0.90174185
67MP0002234_abnormal_pharynx_morphology0.86507593
68MP0005503_abnormal_tendon_morphology0.85001780
69MP0004134_abnormal_chest_morphology0.83579738
70MP0005448_abnormal_energy_balance0.83223250
71MP0002095_abnormal_skin_pigmentation0.82321456
72MP0005551_abnormal_eye_electrophysiolog0.82161686
73MP0000653_abnormal_sex_gland0.81259077
74MP0005025_abnormal_response_to0.81189529
75MP0002452_abnormal_antigen_presenting0.80785289
76MP0001929_abnormal_gametogenesis0.80503635
77MP0006036_abnormal_mitochondrial_physio0.80502837
78MP0002102_abnormal_ear_morphology0.77279816
79MP0001145_abnormal_male_reproductive0.77244038
80MP0004133_heterotaxia0.76062397
81MP0008875_abnormal_xenobiotic_pharmacok0.74242711
82MP0002075_abnormal_coat/hair_pigmentati0.72467537
83MP0006082_CNS_inflammation0.70510900
84MP0005387_immune_system_phenotype0.70042559
85MP0001790_abnormal_immune_system0.70042559
86MP0005253_abnormal_eye_physiology0.68935053
87MP0004808_abnormal_hematopoietic_stem0.68608768
88MP0004484_altered_response_of0.68283429
89MP0005391_vision/eye_phenotype0.66283156
90MP0002089_abnormal_postnatal_growth/wei0.65765359
91MP0009697_abnormal_copulation0.64692732
92MP0002090_abnormal_vision0.63613473
93MP0006072_abnormal_retinal_apoptosis0.63431255
94MP0002160_abnormal_reproductive_system0.63258027
95MP0003186_abnormal_redox_activity0.62410526
96MP0003866_abnormal_defecation0.61371464
97MP0001485_abnormal_pinna_reflex0.59846289
98MP0010155_abnormal_intestine_physiology0.58993783
99MP0001845_abnormal_inflammatory_respons0.58267663
100MP0000613_abnormal_salivary_gland0.57991586

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.03433094
2B lymphocytopenia (HP:0010976)4.97967377
3Abnormality of B cell number (HP:0010975)4.96570191
4T lymphocytopenia (HP:0005403)4.82440245
5IgG deficiency (HP:0004315)4.69215085
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.59709897
7Abnormality of T cell number (HP:0011839)4.53363292
8Elevated erythrocyte sedimentation rate (HP:0003565)4.13988096
9Type 2 muscle fiber atrophy (HP:0003554)3.94994126
10Absent hand (HP:0004050)3.83736288
11Severe combined immunodeficiency (HP:0004430)3.77041400
12Recurrent bronchitis (HP:0002837)3.62270779
13Muscle fiber atrophy (HP:0100295)3.46736382
14Duplication of thumb phalanx (HP:0009942)3.46258160
15Abnormality of T cells (HP:0002843)3.35454190
16Neonatal respiratory distress (HP:0002643)3.29106712
17Thyroiditis (HP:0100646)3.26894321
18Aplastic anemia (HP:0001915)3.15226394
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.11931926
20Abnormality of DNA repair (HP:0003254)3.09347488
21Abnormal number of erythroid precursors (HP:0012131)3.06830213
22Albinism (HP:0001022)2.91096794
23Short tibia (HP:0005736)2.90903902
24Abnormal rod and cone electroretinograms (HP:0008323)2.87014698
25Abnormality of chromosome stability (HP:0003220)2.85326503
26IgA deficiency (HP:0002720)2.84464876
27Combined immunodeficiency (HP:0005387)2.83438588
28Dyskinesia (HP:0100660)2.80194055
29Fibular aplasia (HP:0002990)2.69190188
30Meckel diverticulum (HP:0002245)2.65116163
31Aplasia involving bones of the extremities (HP:0009825)2.64913226
32Aplasia involving bones of the upper limbs (HP:0009823)2.64913226
33Aplasia of the phalanges of the hand (HP:0009802)2.64913226
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.64176947
35Stomach cancer (HP:0012126)2.62603078
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58708477
37Hypoplasia of the thymus (HP:0000778)2.57760239
38Abnormality of the renal cortex (HP:0011035)2.57718353
39Abnormality of the ileum (HP:0001549)2.53059461
40Ectopic kidney (HP:0000086)2.51937185
41Abnormality of eosinophils (HP:0001879)2.49382046
42Arthropathy (HP:0003040)2.48557598
43Delayed CNS myelination (HP:0002188)2.47937602
44Severe muscular hypotonia (HP:0006829)2.44649084
45Clubbing of toes (HP:0100760)2.44352719
46Reticulocytopenia (HP:0001896)2.39363854
47Abnormality of cells of the erythroid lineage (HP:0012130)2.38176850
48Chromsome breakage (HP:0040012)2.31784958
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29335847
50Flat capital femoral epiphysis (HP:0003370)2.27002380
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.26739026
52Absent/shortened dynein arms (HP:0200106)2.26739026
53Abnormality of the preputium (HP:0100587)2.26631190
54Mesangial abnormality (HP:0001966)2.24871375
55Abnormality of T cell physiology (HP:0011840)2.23479362
56Sloping forehead (HP:0000340)2.22610113
57Panhypogammaglobulinemia (HP:0003139)2.22436949
58Hypomagnesemia (HP:0002917)2.19399537
59Bronchitis (HP:0012387)2.17918823
60Constricted visual fields (HP:0001133)2.17210027
61Hypoplasia of the pons (HP:0012110)2.16661344
62Duplicated collecting system (HP:0000081)2.14407292
63Colon cancer (HP:0003003)2.12585750
64Gonadotropin excess (HP:0000837)2.12448073
65Postaxial foot polydactyly (HP:0001830)2.10671729
66Triphalangeal thumb (HP:0001199)2.10239717
67Congenital, generalized hypertrichosis (HP:0004540)2.08515606
68Renal cortical cysts (HP:0000803)2.08215673
69Leukopenia (HP:0001882)2.07543881
70Abnormality of the renal collecting system (HP:0004742)2.05188008
71Absent thumb (HP:0009777)2.03459590
72Polyuria (HP:0000103)2.00085839
73Progressive microcephaly (HP:0000253)1.97654274
74Abnormality of the phalanges of the hallux (HP:0010057)1.97248329
75Absent radius (HP:0003974)1.96241289
76Mesomelia (HP:0003027)1.90478610
77Abnormality of the pons (HP:0007361)1.88749742
78Abnormality of the labia minora (HP:0012880)1.88304759
79Abnormality of the carotid arteries (HP:0005344)1.87699541
80Neck muscle weakness (HP:0000467)1.86974038
81Type I transferrin isoform profile (HP:0003642)1.86696768
82Congenital stationary night blindness (HP:0007642)1.85728803
83Lymphopenia (HP:0001888)1.84132131
84Bronchiectasis (HP:0002110)1.83253182
85Absent forearm bone (HP:0003953)1.83235768
86Aplasia involving forearm bones (HP:0009822)1.83235768
87Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82982512
88Chronic otitis media (HP:0000389)1.81243027
89Median cleft lip (HP:0000161)1.80487442
90Abnormal biliary tract physiology (HP:0012439)1.80227465
91Bile duct proliferation (HP:0001408)1.80227465
92Focal motor seizures (HP:0011153)1.77786473
93Preaxial hand polydactyly (HP:0001177)1.76902962
94Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76159033
95Posterior subcapsular cataract (HP:0007787)1.75516463
96Ulnar deviation of the wrist (HP:0003049)1.74917118
97Myositis (HP:0100614)1.74515330
98Lymphoma (HP:0002665)1.73952128
99Cavernous hemangioma (HP:0001048)1.73244131
100Eosinophilia (HP:0001880)1.73172830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.77332865
2TXK6.02108726
3TESK23.31907563
4ARAF3.14180560
5LATS13.11522071
6TAOK32.45499488
7NUAK12.40715697
8CDC72.04750244
9MAP3K92.03128159
10LIMK11.96566159
11KDR1.91965894
12BTK1.70152624
13VRK21.61535800
14EPHA41.59367445
15WNK41.55126653
16PRKCQ1.41660927
17GRK61.40026790
18TLK11.30014797
19ZAP701.29956954
20MAP3K131.18851708
21MST41.17851498
22MAPKAPK31.15806671
23PIM21.13234081
24TEC1.13010991
25MARK31.12600841
26TESK11.08277438
27BCKDK1.06935511
28SYK1.05883639
29FRK1.02713940
30NME21.01874976
31ERBB31.01376453
32MAPK71.00803587
33ZAK0.99024504
34MAP3K120.96501094
35BRAF0.94828255
36GRK10.90007421
37DYRK30.88552357
38FES0.88314402
39PIM10.87293607
40MOS0.86437472
41MINK10.86335853
42ITK0.86100627
43CSK0.84032218
44TBK10.82416416
45ABL20.81384783
46DAPK10.77804367
47BCR0.76935686
48RAF10.75848734
49MAP2K20.73488856
50ATR0.72690753
51PIK3CA0.71939459
52LCK0.71306786
53VRK10.64514302
54AKT30.63870281
55PLK40.62551743
56CSNK1G30.61060926
57ERBB20.60907127
58CSNK1G10.60444893
59PHKG10.57407561
60PHKG20.57407561
61CSNK1G20.57056934
62IRAK10.54126520
63TRIM280.53738178
64MAPK120.53737262
65WEE10.52978793
66ADRBK20.52126741
67MAP2K60.52098848
68PDPK10.50897096
69PLK20.48160183
70PBK0.47465547
71LYN0.47302065
72PRKG20.47260673
73NLK0.46549511
74MAP3K110.46202813
75STK30.45683122
76HCK0.43682827
77GRK50.42773635
78WNK30.41885983
79FLT30.41188634
80NTRK10.40911990
81TNIK0.39991889
82DYRK1A0.39560615
83ABL10.37413007
84RPS6KA40.37259717
85CSNK1A10.36900349
86KSR10.36191180
87CSNK1A1L0.35530021
88MATK0.34373218
89CSNK1D0.32584241
90TAF10.32339200
91PTK2B0.32017594
92JAK10.32007362
93INSRR0.31591653
94INSR0.31025898
95TNK20.29168566
96MAPK110.29114641
97MAP2K10.29014247
98CSNK2A10.27871432
99GRK70.27502349
100STK390.26837491

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.14847484
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.72762377
3RNA polymerase_Homo sapiens_hsa030203.12441459
4Proteasome_Homo sapiens_hsa030503.08835372
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.71925026
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.58148878
7Fanconi anemia pathway_Homo sapiens_hsa034602.48575464
8Mismatch repair_Homo sapiens_hsa034302.31744038
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27993971
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27811278
11T cell receptor signaling pathway_Homo sapiens_hsa046602.03472056
12Homologous recombination_Homo sapiens_hsa034401.89113201
13Oxidative phosphorylation_Homo sapiens_hsa001901.78721973
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.72436575
15DNA replication_Homo sapiens_hsa030301.69945751
16Circadian rhythm_Homo sapiens_hsa047101.69791424
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67972410
18Caffeine metabolism_Homo sapiens_hsa002321.63190190
19Parkinsons disease_Homo sapiens_hsa050121.61665561
20Base excision repair_Homo sapiens_hsa034101.59546070
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59093692
22Pyrimidine metabolism_Homo sapiens_hsa002401.56964842
23Steroid biosynthesis_Homo sapiens_hsa001001.52482029
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48903253
25Phototransduction_Homo sapiens_hsa047441.47468291
26Autoimmune thyroid disease_Homo sapiens_hsa053201.32520469
27Graft-versus-host disease_Homo sapiens_hsa053321.29928898
28One carbon pool by folate_Homo sapiens_hsa006701.26788659
29Purine metabolism_Homo sapiens_hsa002301.25976357
30Protein export_Homo sapiens_hsa030601.21618446
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18705069
32Allograft rejection_Homo sapiens_hsa053301.18322142
33Huntingtons disease_Homo sapiens_hsa050161.17279146
34RNA degradation_Homo sapiens_hsa030181.16694146
35Peroxisome_Homo sapiens_hsa041461.15276159
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11322480
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11002753
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09557657
39Antigen processing and presentation_Homo sapiens_hsa046121.09031377
40Hematopoietic cell lineage_Homo sapiens_hsa046401.06972412
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03649108
42Dorso-ventral axis formation_Homo sapiens_hsa043201.02497594
43Nucleotide excision repair_Homo sapiens_hsa034201.01941039
44Shigellosis_Homo sapiens_hsa051311.01013960
45Ribosome_Homo sapiens_hsa030100.94991398
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90117438
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86170640
48Chemical carcinogenesis_Homo sapiens_hsa052040.82286323
49Sulfur metabolism_Homo sapiens_hsa009200.80836238
50Thyroid cancer_Homo sapiens_hsa052160.78516178
51Retinol metabolism_Homo sapiens_hsa008300.78082041
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76800437
53Type I diabetes mellitus_Homo sapiens_hsa049400.73500430
54Alzheimers disease_Homo sapiens_hsa050100.72704563
55Butanoate metabolism_Homo sapiens_hsa006500.68601724
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67804596
57Linoleic acid metabolism_Homo sapiens_hsa005910.67666264
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66963346
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66768879
60Spliceosome_Homo sapiens_hsa030400.65516698
61Tryptophan metabolism_Homo sapiens_hsa003800.64272647
62African trypanosomiasis_Homo sapiens_hsa051430.63063269
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61550329
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.60496945
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58798957
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.58529391
67Propanoate metabolism_Homo sapiens_hsa006400.57802459
68Hedgehog signaling pathway_Homo sapiens_hsa043400.57040667
69p53 signaling pathway_Homo sapiens_hsa041150.54118073
70Vitamin B6 metabolism_Homo sapiens_hsa007500.52845024
71Basal cell carcinoma_Homo sapiens_hsa052170.52521045
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.51130727
73Salivary secretion_Homo sapiens_hsa049700.45742311
74Metabolic pathways_Homo sapiens_hsa011000.45129177
75Rheumatoid arthritis_Homo sapiens_hsa053230.45059982
76Nitrogen metabolism_Homo sapiens_hsa009100.43390180
77Oocyte meiosis_Homo sapiens_hsa041140.42865697
78Morphine addiction_Homo sapiens_hsa050320.42313682
79Arginine biosynthesis_Homo sapiens_hsa002200.41852037
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41739721
81Malaria_Homo sapiens_hsa051440.39186470
82Glycerolipid metabolism_Homo sapiens_hsa005610.38706872
83Regulation of autophagy_Homo sapiens_hsa041400.37347281
84Inositol phosphate metabolism_Homo sapiens_hsa005620.34606820
85Prion diseases_Homo sapiens_hsa050200.34496925
86Mineral absorption_Homo sapiens_hsa049780.32909219
87Glutathione metabolism_Homo sapiens_hsa004800.32020199
88Wnt signaling pathway_Homo sapiens_hsa043100.32006545
89Folate biosynthesis_Homo sapiens_hsa007900.31947800
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30327652
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.29355174
92Olfactory transduction_Homo sapiens_hsa047400.28774540
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26741283
94ABC transporters_Homo sapiens_hsa020100.24224602
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.23791212
96RNA transport_Homo sapiens_hsa030130.23609293
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22760569
98Measles_Homo sapiens_hsa051620.19980172
99Asthma_Homo sapiens_hsa053100.19777310
100Viral myocarditis_Homo sapiens_hsa054160.19552686

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