ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	seminiferous tubule development (GO:0072520)	9.71854613
2	positive regulation of RNA splicing (GO:0033120)	9.66859202
3	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	9.21633704
4	cAMP biosynthetic process (GO:0006171)	8.88837503
5	detection of chemical stimulus involved in sensory perception (GO:0050907)	8.53176368
6	negative regulation of alpha-beta T cell differentiation (GO:0046639)	8.41108367
7	enteric nervous system development (GO:0048484)	7.88041628
8	regulation of protein sumoylation (GO:0033233)	7.55921058
9	synaptic transmission, dopaminergic (GO:0001963)	7.05648820
10	dendritic spine morphogenesis (GO:0060997)	7.00764633
11	positive regulation of mitochondrial fission (GO:0090141)	6.97215532
12	righting reflex (GO:0060013)	6.96225050
13	heterotypic cell-cell adhesion (GO:0034113)	6.58303385
14	positive regulation of T-helper 1 type immune response (GO:0002827)	6.29766929
15	detection of chemical stimulus (GO:0009593)	6.13015869
16	arachidonic acid secretion (GO:0050482)	6.04985906
17	icosanoid secretion (GO:0032309)	6.04985906
18	hepatocyte apoptotic process (GO:0097284)	6.00184372
19	endothelial cell differentiation (GO:0045446)	5.92663373
20	positive regulation of T-helper cell differentiation (GO:0045624)	5.76564349
21	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.51768697
22	drug transmembrane transport (GO:0006855)	5.24710321
23	neuronal ion channel clustering (GO:0045161)	5.14501807
24	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.13953299
25	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	5.11549522
26	regulation of mitochondrial fission (GO:0090140)	5.09485573
27	fatty acid derivative transport (GO:1901571)	5.00088193
28	icosanoid transport (GO:0071715)	5.00088193
29	negative regulation of alpha-beta T cell activation (GO:0046636)	4.84008530
30	chemosensory behavior (GO:0007635)	4.80219020
31	neural tube formation (GO:0001841)	4.73831607
32	hyaluronan catabolic process (GO:0030214)	4.68276910
33	cilium or flagellum-dependent cell motility (GO:0001539)	4.52371069
34	regulation of T-helper 1 type immune response (GO:0002825)	4.52038328
35	embryonic digestive tract morphogenesis (GO:0048557)	4.51654529
36	vocalization behavior (GO:0071625)	4.45321076
37	cyclic purine nucleotide metabolic process (GO:0052652)	4.43584114
38	nephron tubule morphogenesis (GO:0072078)	4.41004993
39	nephron epithelium morphogenesis (GO:0072088)	4.41004993
40	ATP hydrolysis coupled proton transport (GO:0015991)	4.40019870
41	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	4.40019870
42	positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	4.36314801
43	retina layer formation (GO:0010842)	4.33370437
44	attachment of spindle microtubules to kinetochore (GO:0008608)	4.33167515
45	cyclic nucleotide biosynthetic process (GO:0009190)	4.29034250
46	positive regulation of membrane potential (GO:0045838)	4.26776864
47	cellular response to glucagon stimulus (GO:0071377)	4.21754585
48	regulation of T-helper cell differentiation (GO:0045622)	4.21585868
49	response to dietary excess (GO:0002021)	4.19543039
50	regulation of cAMP-mediated signaling (GO:0043949)	4.18914851
51	water transport (GO:0006833)	4.13238956
52	regulation of type 2 immune response (GO:0002828)	4.10949381
53	negative regulation of actin filament bundle assembly (GO:0032232)	4.09970343
54	mitochondrial fusion (GO:0008053)	4.01913629
55	dendritic spine organization (GO:0097061)	4.01911257
56	cAMP metabolic process (GO:0046058)	3.99428471
57	protein localization to synapse (GO:0035418)	3.92647487
58	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.87316228
59	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.86541392
60	positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	3.82671603
61	cellular zinc ion homeostasis (GO:0006882)	3.73939620
62	negative regulation of T cell differentiation (GO:0045581)	3.71104473
63	fluid transport (GO:0042044)	3.68633559
64	monoamine transport (GO:0015844)	3.68089314
65	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.66875836
66	drug transport (GO:0015893)	3.59966176
67	positive regulation of protein targeting to membrane (GO:0090314)	3.58805923
68	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.57854032
69	leukotriene biosynthetic process (GO:0019370)	3.56999653
70	cellular response to ATP (GO:0071318)	3.55815276
71	pre-miRNA processing (GO:0031054)	3.48065791
72	sulfur amino acid catabolic process (GO:0000098)	3.47570849
73	sequestering of metal ion (GO:0051238)	3.43206618
74	negative regulation of homotypic cell-cell adhesion (GO:0034111)	3.41968627
75	left/right axis specification (GO:0070986)	3.32028175
76	regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)	3.30012875
77	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.28519644
78	positive regulation of alpha-beta T cell differentiation (GO:0046638)	3.27100925
79	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.24569846
80	negative regulation of astrocyte differentiation (GO:0048712)	3.21472891
81	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.19010671
82	renal tubule morphogenesis (GO:0061333)	3.18823045
83	neuromuscular process controlling posture (GO:0050884)	3.16148791
84	neurofilament cytoskeleton organization (GO:0060052)	3.15319179
85	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.13945782
86	response to glucagon (GO:0033762)	3.12784019
87	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.12782410
88	adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)	3.10521107
89	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)	3.07294651
90	reflex (GO:0060004)	3.06310082
91	tooth mineralization (GO:0034505)	14.3957010
92	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	13.6886399
93	positive regulation of protein sumoylation (GO:0033235)	11.9604019
94	negative regulation of T-helper cell differentiation (GO:0045623)	11.4846309
95	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	11.4846309
96	protein K11-linked deubiquitination (GO:0035871)	10.7086658
97	regulation of T-helper 1 cell differentiation (GO:0045625)	10.2588027
98	activation of protein kinase A activity (GO:0034199)	10.1048040
99	regulation of T-helper 2 cell differentiation (GO:0045628)	10.0966558
100	negative regulation of type 2 immune response (GO:0002829)	10.0475398

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.62251686
2	EGR1_19374776_ChIP-ChIP_THP-1_Human	5.54573510
3	IGF1R_20145208_ChIP-Seq_DFB_Human	4.85930961
4	AR_21572438_ChIP-Seq_LNCaP_Human	4.79992010
5	VDR_22108803_ChIP-Seq_LS180_Human	4.26265517
6	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	3.53161227
7	TP53_16413492_ChIP-PET_HCT116_Human	2.08599318
8	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.04839212
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	10.8373624
10	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.94331984
11	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.88824580
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88824580
13	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.88393392
14	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.86526080
15	GATA1_19941826_ChIP-Seq_K562_Human	1.73937850
16	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.69736078
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69511248
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.58559279
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.58471686
20	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.55677558
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.50271118
22	EGR1_19032775_ChIP-ChIP_M12_Human	1.49445280
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47388985
24	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.44579137
25	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.43754416
26	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.42021592
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.39833165
28	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.37626864
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37166331
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36111146
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35473899
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28938193
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27803296
34	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26330368
35	RXR_22108803_ChIP-Seq_LS180_Human	1.22475709
36	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20769598
37	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.18645589
38	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18384079
39	EZH2_22144423_ChIP-Seq_EOC_Human	1.15582417
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11256326
41	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.11031550
42	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.10645548
43	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.09172481
44	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.08378687
45	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07085859
46	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.06519941
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05743470
48	GBX2_23144817_ChIP-Seq_PC3_Human	1.05302221
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.05248601
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.05133217
51	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04320304
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03670262
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02486154
54	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.02038555
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01937589
56	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00445628
57	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.00068537
58	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99366613
59	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98961896
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98839130
61	TBL1_22424771_ChIP-Seq_293T_Human	0.98822712
62	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.98628003
63	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97608081
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96536922
65	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.96523869
66	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.96364217
67	PHF8_20622853_ChIP-Seq_HELA_Human	0.95713922
68	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95173523
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93265244
70	BCAT_22108803_ChIP-Seq_LS180_Human	0.93101310
71	STAT3_23295773_ChIP-Seq_U87_Human	0.90871622
72	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.89011016
73	CJUN_26792858_Chip-Seq_BT549_Human	0.88803939
74	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.88771577
75	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.88576093
76	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.88240181
77	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87210067
78	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.86893079
79	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.86885155
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.86244535
81	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.85601071
82	CTCF_27219007_Chip-Seq_Bcells_Human	0.84730806
83	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.84356972
84	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.83878540
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.83807827
86	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.83700856
87	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.83575355
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.82782037
89	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.81728298
90	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.81728298
91	REST_21632747_ChIP-Seq_MESCs_Mouse	0.81662840
92	ZNF274_21170338_ChIP-Seq_K562_Hela	0.80418760
93	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.79416336
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.77197879
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.76282314
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.75666103
97	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.75478679
98	SMAD4_21799915_ChIP-Seq_A2780_Human	0.75469689
99	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.75404851
100	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.75063556

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008961_abnormal_basal_metabolism	9.68930871
2	MP0004130_abnormal_muscle_cell	4.93967388
3	MP0004264_abnormal_extraembryonic_tissu	3.97525289
4	MP0003252_abnormal_bile_duct	3.65399340
5	MP0004133_heterotaxia	2.89402738
6	MP0002928_abnormal_bile_duct	2.74299632
7	MP0006072_abnormal_retinal_apoptosis	2.53525219
8	MP0002751_abnormal_autonomic_nervous	2.34674994
9	MP0005448_abnormal_energy_balance	2.27979059
10	MP0005408_hypopigmentation	2.27870461
11	MP0001270_distended_abdomen	2.11482364
12	MP0003329_amyloid_beta_deposits	2.10349381
13	MP0004272_abnormal_basement_membrane	2.05650194
14	MP0005084_abnormal_gallbladder_morpholo	12.7153948
15	MP0003943_abnormal_hepatobiliary_system	1.81237799
16	MP0005220_abnormal_exocrine_pancreas	1.71047928
17	MP0005379_endocrine/exocrine_gland_phen	1.55468721
18	MP0005165_increased_susceptibility_to	1.54467716
19	MP0001958_emphysema	1.43954077
20	MP0001529_abnormal_vocalization	1.39873457
21	MP0009764_decreased_sensitivity_to	1.38733605
22	MP0000604_amyloidosis	1.33780250
23	MP0003718_maternal_effect	1.33081614
24	MP0005646_abnormal_pituitary_gland	1.22415431
25	MP0001905_abnormal_dopamine_level	1.08008804
26	MP0002572_abnormal_emotion/affect_behav	1.01668740
27	MP0002909_abnormal_adrenal_gland	0.99802380
28	MP0000470_abnormal_stomach_morphology	0.99296971
29	MP0001944_abnormal_pancreas_morphology	0.98413078
30	MP0000465_gastrointestinal_hemorrhage	0.98086485
31	MP0008569_lethality_at_weaning	0.94258309
32	MP0003638_abnormal_response/metabolism_	0.93293623
33	MP0001915_intracranial_hemorrhage	0.81306399
34	MP0008875_abnormal_xenobiotic_pharmacok	0.80727435
35	MP0000371_diluted_coat_color	0.80256679
36	MP0004019_abnormal_vitamin_homeostasis	0.77572429
37	MP0003121_genomic_imprinting	0.76381223
38	MP0008469_abnormal_protein_level	0.75428550
39	MP0005253_abnormal_eye_physiology	0.73806366
40	MP0005164_abnormal_response_to	0.73450890
41	MP0002098_abnormal_vibrissa_morphology	0.72875753
42	MP0001800_abnormal_humoral_immune	0.70240454
43	MP0002405_respiratory_system_inflammati	0.69007174
44	MP0002693_abnormal_pancreas_physiology	0.68486696
45	MP0000609_abnormal_liver_physiology	0.68064833
46	MP0003866_abnormal_defecation	0.68014411
47	MP0002078_abnormal_glucose_homeostasis	0.62687638
48	MP0003953_abnormal_hormone_level	0.62549191
49	MP0002136_abnormal_kidney_physiology	0.61577811
50	MP0000703_abnormal_thymus_morphology	0.61471320
51	MP0001851_eye_inflammation	0.60838113
52	MP0001790_abnormal_immune_system	0.56805437
53	MP0005387_immune_system_phenotype	0.56805437
54	MP0001533_abnormal_skeleton_physiology	0.56648813
55	MP0004947_skin_inflammation	0.53372298
56	MP0002998_abnormal_bone_remodeling	0.52300828
57	MP0005423_abnormal_somatic_nervous	0.47603844
58	MP0005551_abnormal_eye_electrophysiolog	0.47290233
59	MP0009642_abnormal_blood_homeostasis	0.46643070
60	MP0001845_abnormal_inflammatory_respons	0.45839246
61	MP0001501_abnormal_sleep_pattern	0.43117157
62	MP0001986_abnormal_taste_sensitivity	0.42340516
63	MP0008004_abnormal_stomach_pH	0.42183091
64	MP0003195_calcinosis	0.41716934
65	MP0002722_abnormal_immune_system	0.41305143
66	MP0002822_catalepsy	0.38312375
67	MP0005334_abnormal_fat_pad	0.38161511
68	MP0002882_abnormal_neuron_morphology	0.35650344
69	MP0000920_abnormal_myelination	0.35034027
70	MP0000477_abnormal_intestine_morphology	0.34856569
71	MP0000759_abnormal_skeletal_muscle	0.34424969
72	MP0001299_abnormal_eye_distance/	0.34209222
73	MP0002429_abnormal_blood_cell	0.33356959
74	MP0000598_abnormal_liver_morphology	0.32797506
75	MP0002419_abnormal_innate_immunity	0.32615887
76	MP0005365_abnormal_bile_salt	0.32613115
77	MP0009931_abnormal_skin_appearance	0.32210372
78	MP0002229_neurodegeneration	0.32207930
79	MP0004484_altered_response_of	0.31123245
80	MP0005390_skeleton_phenotype	0.30886406
81	MP0002452_abnormal_antigen_presenting	0.29936448
82	MP0002735_abnormal_chemical_nociception	0.29604701
83	MP0005395_other_phenotype	0.29495500
84	MP0005391_vision/eye_phenotype	0.26970987
85	MP0000716_abnormal_immune_system	0.26317728
86	MP0002420_abnormal_adaptive_immunity	0.26308725
87	MP0001819_abnormal_immune_cell	0.25941549
88	MP0001175_abnormal_lung_morphology	0.25482546
89	MP0005645_abnormal_hypothalamus_physiol	0.24430835
90	MP0002066_abnormal_motor_capabilities/c	0.23894268
91	MP0002398_abnormal_bone_marrow	0.22610748
92	MP0002161_abnormal_fertility/fecundity	0.21962246
93	MP0002736_abnormal_nociception_after	0.21937565
94	MP0001293_anophthalmia	0.21264397
95	MP0002723_abnormal_immune_serum	0.21252304
96	MP0005000_abnormal_immune_tolerance	0.21028672
97	MP0005636_abnormal_mineral_homeostasis	0.20083492
98	MP0002113_abnormal_skeleton_development	0.20076877
99	MP0003880_abnormal_central_pattern	0.20057320
100	MP0002396_abnormal_hematopoietic_system	0.19904275

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of dental color (HP:0011073)	8.34669035
2	Abnormality of renal resorption (HP:0011038)	8.25775519
3	Osteomalacia (HP:0002749)	7.83757815
4	Polyuria (HP:0000103)	7.66694841
5	Abnormality of the dental pulp (HP:0006479)	7.55957761
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.02334842
7	Abnormal urine output (HP:0012590)	6.55006449
8	Abnormality of renal excretion (HP:0011036)	5.73054235
9	Round ear (HP:0100830)	5.41299879
10	Chronic bronchitis (HP:0004469)	5.11498422
11	IgM deficiency (HP:0002850)	4.31318117
12	Volvulus (HP:0002580)	4.27851785
13	Lip pit (HP:0100267)	4.18519397
14	Molar tooth sign on MRI (HP:0002419)	3.99414678
15	Abnormality of midbrain morphology (HP:0002418)	3.99414678
16	Toxemia of pregnancy (HP:0100603)	3.94358339
17	Autoimmune thrombocytopenia (HP:0001973)	3.93984226
18	Nephrocalcinosis (HP:0000121)	3.85449105
19	Esophageal varix (HP:0002040)	3.68901646
20	Abnormal respiratory motile cilium physiology (HP:0012261)	3.43891324
21	Lipoatrophy (HP:0100578)	3.40708019
22	Sparse lateral eyebrow (HP:0005338)	3.39648911
23	Rhinitis (HP:0012384)	3.38672863
24	Depressed nasal tip (HP:0000437)	3.37034850
25	Tachypnea (HP:0002789)	3.29461648
26	Large earlobe (HP:0009748)	3.24405987
27	Hypoparathyroidism (HP:0000829)	3.18807037
28	Drooling (HP:0002307)	3.18507462
29	Excessive salivation (HP:0003781)	3.04591229
30	Intestinal fistula (HP:0100819)	3.01298452
31	Hyperphosphaturia (HP:0003109)	2.99751966
32	Panhypogammaglobulinemia (HP:0003139)	2.98882464
33	Nephronophthisis (HP:0000090)	2.81102430
34	Thick eyebrow (HP:0000574)	2.80208873
35	Personality changes (HP:0000751)	2.77988461
36	Petechiae (HP:0000967)	2.64850322
37	Abnormal urine phosphate concentration (HP:0012599)	2.49962353
38	Dilated cardiomyopathy (HP:0001644)	2.49949882
39	Glycosuria (HP:0003076)	2.47419324
40	Abnormality of urine glucose concentration (HP:0011016)	2.47419324
41	Hepatitis (HP:0012115)	2.46010551
42	Ureteral stenosis (HP:0000071)	2.44968998
43	Short 5th finger (HP:0009237)	2.44774912
44	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.33057566
45	Nephropathy (HP:0000112)	2.32442019
46	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.29531398
47	Abnormality of the fingertips (HP:0001211)	2.28596666
48	Gingival overgrowth (HP:0000212)	2.26587940
49	Sudden cardiac death (HP:0001645)	2.25702442
50	Ureteral obstruction (HP:0006000)	2.24674552
51	Abnormality of transition element cation homeostasis (HP:0011030)	2.23952469
52	Recurrent cutaneous fungal infections (HP:0011370)	2.23337811
53	Chronic mucocutaneous candidiasis (HP:0002728)	2.23337811
54	Bronchitis (HP:0012387)	2.19909711
55	Striae distensae (HP:0001065)	2.15587135
56	Anal stenosis (HP:0002025)	2.15552911
57	Hypercalciuria (HP:0002150)	2.15425211
58	Preauricular pit (HP:0004467)	2.15019120
59	Periauricular skin pits (HP:0100277)	2.15019120
60	Inability to walk (HP:0002540)	2.13858727
61	Decreased muscle mass (HP:0003199)	2.13029465
62	Colitis (HP:0002583)	2.12851217
63	Recurrent otitis media (HP:0000403)	2.10798093
64	Abnormality of the renal medulla (HP:0100957)	2.09254287
65	Agammaglobulinemia (HP:0004432)	2.05095287
66	Chondrocalcinosis (HP:0000934)	2.01713105
67	Overgrowth (HP:0001548)	12.3707995
68	Amelogenesis imperfecta (HP:0000705)	11.7463326
69	Abnormality of calcium-phosphate metabolism (HP:0100530)	10.0470958
70	Chorioretinal coloboma (HP:0000567)	1.98462124
71	Abnormality of Sharpey fibers (HP:0100685)	1.96615134
72	Abnormality of salivation (HP:0100755)	1.96519435
73	Ectopic kidney (HP:0000086)	1.93975391
74	Delayed eruption of teeth (HP:0000684)	1.92906862
75	Renal tubular dysfunction (HP:0000124)	1.89042912
76	Preauricular skin tag (HP:0000384)	1.83639839
77	Stage 5 chronic kidney disease (HP:0003774)	1.78897579
78	Prominent supraorbital ridges (HP:0000336)	1.74399436
79	Truncal ataxia (HP:0002078)	1.74295603
80	Small hand (HP:0200055)	1.68703204
81	Villous atrophy (HP:0011473)	1.67971092
82	Abnormality of small intestinal villus morphology (HP:0011472)	1.67971092
83	Limited elbow extension (HP:0001377)	1.65623411
84	Torticollis (HP:0000473)	1.64685339
85	Oculomotor apraxia (HP:0000657)	1.63775503
86	Ectropion (HP:0000656)	1.59433426
87	Palmoplantar keratoderma (HP:0000982)	1.56976315
88	Bronchiectasis (HP:0002110)	1.54922835
89	Skin tags (HP:0010609)	1.53618945
90	Blepharitis (HP:0000498)	1.50120502
91	Highly arched eyebrow (HP:0002553)	1.49352308
92	Polyneuropathy (HP:0001271)	1.48625015
93	Prenatal maternal abnormality (HP:0002686)	1.46087117
94	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.44689797
95	Viral hepatitis (HP:0006562)	1.42204674
96	Skin pits (HP:0100276)	1.41646544
97	Mask-like facies (HP:0000298)	1.36973555
98	Proximal placement of thumb (HP:0009623)	1.35285224
99	Inflammation of the large intestine (HP:0002037)	1.30626867
100	Osteoarthritis (HP:0002758)	1.29980787

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K1	5.61035536
2	BLK	4.28405784
3	STK3	4.07909451
4	RIPK4	3.10695072
5	BMPR2	2.23611379
6	CDC42BPA	2.14355215
7	NTRK2	14.2557431
8	HIPK2	1.19938960
9	FGFR1	0.93916865
10	ROCK2	0.78396744
11	INSRR	0.66923613
12	SYK	0.62052340
13	SRC	0.61856743
14	PRKCQ	0.60236683
15	OBSCN	0.59442363
16	PRKAA1	0.56335411
17	ROCK1	0.55537072
18	SRPK1	0.53530399
19	MUSK	0.53518923
20	GRK1	0.49012835
21	MAP4K2	0.46655539
22	GRK7	0.46172836
23	MAPK15	0.45773522
24	WNK3	0.44496890
25	PRKACG	0.43994833
26	ABL1	0.42303999
27	ADRBK2	0.39959744
28	TIE1	0.39543722
29	PRKACA	0.37390077
30	TEC	0.37302520
31	PRKACB	0.36513013
32	TXK	0.35686270
33	CAMK2A	0.32849627
34	PLK1	0.32587099
35	PIK3CG	0.32360645
36	ERBB4	0.31365785
37	EPHA4	0.30409889
38	MATK	0.29609375
39	ITK	0.25384863
40	PLK4	0.24553853
41	PRKCA	0.23027338
42	OXSR1	0.22753662
43	MAPK14	0.22020249
44	LYN	0.21737725
45	PRKCB	0.21477802
46	GSK3B	0.21283505
47	TLK1	0.20521392
48	RPS6KA3	0.19637515
49	GRK5	0.19175427
50	TNK2	0.19079487
51	KIT	0.16679476
52	CSNK1A1	0.16520327
53	LMTK2	0.16258651
54	KDR	0.15615105
55	FYN	0.15328799
56	DDR2	0.15018985
57	CDK1	0.14956880
58	MST1R	0.14608390
59	BTK	0.13377818
60	EPHA2	0.13166243
61	PRKCD	0.12724269
62	PHKG2	0.12677083
63	PHKG1	0.12677083
64	PRKCG	0.12553048
65	PRKDC	0.12477567
66	MAPKAPK5	0.12337621
67	PKN1	0.10909266
68	CAMK2G	0.10829141
69	MAPK9	0.10522773
70	CHUK	0.10512956
71	ABL2	0.09940780
72	STK24	0.09737722
73	STK39	0.09593738
74	WNK4	0.09459372
75	MOS	0.08837263
76	TTN	0.08543368
77	IGF1R	0.08378724
78	VRK1	0.08100029
79	PIM1	0.08065477
80	FRK	0.07887684
81	ADRBK1	0.07247071
82	AKT1	0.07125803
83	HCK	0.07004649
84	PIM2	0.06580843
85	PRKG2	0.06573320
86	EGFR	0.06513548
87	CCNB1	0.06252473
88	PRKCE	0.05728616
89	MAP2K6	0.05252895
90	MAPK13	0.05215021
91	CAMK2D	0.04945157
92	GRK6	0.04871389
93	LCK	0.04669968
94	CAMK2B	0.04669567
95	PIK3CA	0.04319437
96	CDC7	0.03871639
97	SGK1	0.03802732
98	CASK	0.03794508
99	PINK1	0.03397250
100	MARK1	0.03200198

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	5.30476290
2	Sulfur metabolism_Homo sapiens_hsa00920	3.74237678
3	Sulfur relay system_Homo sapiens_hsa04122	3.68665093
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.35240362
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.22846153
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.96069540
7	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	2.87792041
8	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.71897140
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.57131969
10	Vibrio cholerae infection_Homo sapiens_hsa05110	2.39812605
11	Bile secretion_Homo sapiens_hsa04976	2.38883395
12	Pancreatic secretion_Homo sapiens_hsa04972	2.24214740
13	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.23009715
14	Fat digestion and absorption_Homo sapiens_hsa04975	2.16837637
15	Salivary secretion_Homo sapiens_hsa04970	2.14923752
16	Gastric acid secretion_Homo sapiens_hsa04971	2.11552935
17	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.04687489
18	Cocaine addiction_Homo sapiens_hsa05030	1.92372169
19	Circadian entrainment_Homo sapiens_hsa04713	1.85847975
20	Insulin secretion_Homo sapiens_hsa04911	1.82255410
21	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.81714197
22	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.74075498
23	Taste transduction_Homo sapiens_hsa04742	1.73353770
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.71789790
25	GABAergic synapse_Homo sapiens_hsa04727	1.68792270
26	Morphine addiction_Homo sapiens_hsa05032	1.67833999
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.67347983
28	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.66693934
29	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.66116431
30	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.64601532
31	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.57383632
32	Gap junction_Homo sapiens_hsa04540	1.53398052
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.44911777
34	Amphetamine addiction_Homo sapiens_hsa05031	1.41205163
35	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.40642291
36	Melanogenesis_Homo sapiens_hsa04916	1.34639355
37	GnRH signaling pathway_Homo sapiens_hsa04912	1.34113648
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29454345
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.24845593
40	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.16867187
41	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.14763135
42	Cholinergic synapse_Homo sapiens_hsa04725	1.12014831
43	Platelet activation_Homo sapiens_hsa04611	1.09808194
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.05996818
45	Estrogen signaling pathway_Homo sapiens_hsa04915	1.04044909
46	Circadian rhythm_Homo sapiens_hsa04710	0.96190946
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.88289962
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.86965641
49	Oocyte meiosis_Homo sapiens_hsa04114	0.78408713
50	Serotonergic synapse_Homo sapiens_hsa04726	0.76342219
51	ECM-receptor interaction_Homo sapiens_hsa04512	0.71400307
52	Chemokine signaling pathway_Homo sapiens_hsa04062	0.67935221
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.66600157
54	RNA degradation_Homo sapiens_hsa03018	0.63156425
55	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.62210580
56	Parkinsons disease_Homo sapiens_hsa05012	0.50808528
57	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.47392504
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.45317779
59	Caffeine metabolism_Homo sapiens_hsa00232	0.38867530
60	Alcoholism_Homo sapiens_hsa05034	0.38503189
61	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.38227792
62	Oxidative phosphorylation_Homo sapiens_hsa00190	0.37369944
63	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.36840907
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33714775
65	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.33323152
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33119619
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.32744963
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31600855
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.31074554
70	Purine metabolism_Homo sapiens_hsa00230	0.28996372
71	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.26539011
72	Prion diseases_Homo sapiens_hsa05020	0.24874078
73	Rap1 signaling pathway_Homo sapiens_hsa04015	0.21513058
74	Retinol metabolism_Homo sapiens_hsa00830	0.21299937
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.18015580
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.15022592
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.14035425
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.13466685
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.13196256
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.12316805
81	Phagosome_Homo sapiens_hsa04145	0.11330872
82	Ras signaling pathway_Homo sapiens_hsa04014	0.09741405
83	HTLV-I infection_Homo sapiens_hsa05166	0.09388723
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.09383371
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.08459259
86	Tuberculosis_Homo sapiens_hsa05152	0.08067308
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.06648486
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.06615615
89	Nicotine addiction_Homo sapiens_hsa05033	0.06151015
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.05031282
91	African trypanosomiasis_Homo sapiens_hsa05143	0.03748067
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.01703792
93	Renin secretion_Homo sapiens_hsa04924	0.01158355
94	Leishmaniasis_Homo sapiens_hsa05140	0.00832017
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	-0.0560192
96	Amoebiasis_Homo sapiens_hsa05146	-0.0542408
97	Asthma_Homo sapiens_hsa05310	-0.0360916
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	-0.0141195
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	-0.0101601
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	-0.0052389

OR7E158P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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