OR7E18P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.65499281
2positive regulation of RNA splicing (GO:0033120)9.64085760
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.15396756
4cAMP biosynthetic process (GO:0006171)8.82566073
5detection of chemical stimulus involved in sensory perception (GO:0050907)8.49618794
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.34231245
7enteric nervous system development (GO:0048484)7.85817749
8regulation of protein sumoylation (GO:0033233)7.53979768
9dendritic spine morphogenesis (GO:0060997)7.06663203
10synaptic transmission, dopaminergic (GO:0001963)7.06030944
11righting reflex (GO:0060013)6.98580485
12positive regulation of mitochondrial fission (GO:0090141)6.97627665
13heterotypic cell-cell adhesion (GO:0034113)6.49721936
14positive regulation of T-helper 1 type immune response (GO:0002827)6.37034273
15detection of chemical stimulus (GO:0009593)6.10445920
16icosanoid secretion (GO:0032309)6.01286919
17arachidonic acid secretion (GO:0050482)6.01286919
18hepatocyte apoptotic process (GO:0097284)6.00216452
19endothelial cell differentiation (GO:0045446)5.90883816
20positive regulation of T-helper cell differentiation (GO:0045624)5.82332940
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.54819156
22drug transmembrane transport (GO:0006855)5.30880720
23phosphatidylserine acyl-chain remodeling (GO:0036150)5.17436296
24regulation of mitochondrial fission (GO:0090140)5.11475105
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.06530627
26neuronal ion channel clustering (GO:0045161)5.01446650
27icosanoid transport (GO:0071715)4.98065696
28fatty acid derivative transport (GO:1901571)4.98065696
29negative regulation of alpha-beta T cell activation (GO:0046636)4.85618500
30neural tube formation (GO:0001841)4.79923361
31chemosensory behavior (GO:0007635)4.78057255
32hyaluronan catabolic process (GO:0030214)4.71265939
33regulation of T-helper 1 type immune response (GO:0002825)4.57750270
34cilium or flagellum-dependent cell motility (GO:0001539)4.51510441
35embryonic digestive tract morphogenesis (GO:0048557)4.47140311
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.43299976
37nephron epithelium morphogenesis (GO:0072088)4.41518405
38nephron tubule morphogenesis (GO:0072078)4.41518405
39cyclic purine nucleotide metabolic process (GO:0052652)4.39900348
40ATP hydrolysis coupled proton transport (GO:0015991)4.35720052
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.35720052
42vocalization behavior (GO:0071625)4.34356600
43retina layer formation (GO:0010842)4.28712755
44positive regulation of membrane potential (GO:0045838)4.27691128
45cyclic nucleotide biosynthetic process (GO:0009190)4.26326949
46regulation of T-helper cell differentiation (GO:0045622)4.22880936
47cellular response to glucagon stimulus (GO:0071377)4.21907285
48attachment of spindle microtubules to kinetochore (GO:0008608)4.21676230
49response to dietary excess (GO:0002021)4.20673255
50regulation of cAMP-mediated signaling (GO:0043949)4.20487310
51negative regulation of actin filament bundle assembly (GO:0032232)4.16472531
52regulation of type 2 immune response (GO:0002828)4.14007219
53water transport (GO:0006833)4.08822781
54mitochondrial fusion (GO:0008053)4.05207467
55dendritic spine organization (GO:0097061)4.01865363
56protein localization to synapse (GO:0035418)3.99667809
57cAMP metabolic process (GO:0046058)3.98398394
58positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.89933406
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.87603183
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.80292680
61monoamine transport (GO:0015844)3.74580796
62cellular zinc ion homeostasis (GO:0006882)3.72179723
63negative regulation of T cell differentiation (GO:0045581)3.70018479
64phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.66160846
65fluid transport (GO:0042044)3.64807778
66drug transport (GO:0015893)3.62247850
67positive regulation of protein targeting to membrane (GO:0090314)3.59904835
68leukotriene biosynthetic process (GO:0019370)3.57874035
69cellular response to ATP (GO:0071318)3.51971773
70pre-miRNA processing (GO:0031054)3.47981724
71sulfur amino acid catabolic process (GO:0000098)3.45247842
72sequestering of metal ion (GO:0051238)3.42395709
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.39440313
74positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.37179062
75positive regulation of alpha-beta T cell differentiation (GO:0046638)3.34367465
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.32703834
77left/right axis specification (GO:0070986)3.31525244
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.19621194
79phosphatidylcholine acyl-chain remodeling (GO:0036151)3.17671938
80renal tubule morphogenesis (GO:0061333)3.15755926
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14907491
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14524499
83response to glucagon (GO:0033762)3.14298621
84negative regulation of astrocyte differentiation (GO:0048712)3.12428084
85neuromuscular process controlling posture (GO:0050884)3.11616282
86adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.10468198
87positive regulation of steroid hormone secretion (GO:2000833)3.09794264
88neurofilament cytoskeleton organization (GO:0060052)3.09337765
89reflex (GO:0060004)3.08115801
90prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.08100874
91tooth mineralization (GO:0034505)14.3333323
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6636188
93positive regulation of protein sumoylation (GO:0033235)11.9980804
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.3876956
95negative regulation of T-helper cell differentiation (GO:0045623)11.3876956
96protein K11-linked deubiquitination (GO:0035871)10.6791616
97regulation of T-helper 1 cell differentiation (GO:0045625)10.3144981
98negative regulation of type 2 immune response (GO:0002829)10.0982132
99regulation of T-helper 2 cell differentiation (GO:0045628)10.0888975
100activation of protein kinase A activity (GO:0034199)10.0693631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.43414962
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.50315778
3IGF1R_20145208_ChIP-Seq_DFB_Human4.76695455
4AR_21572438_ChIP-Seq_LNCaP_Human4.73363247
5VDR_22108803_ChIP-Seq_LS180_Human4.25736072
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.41196941
7TP53_16413492_ChIP-PET_HCT116_Human2.17417524
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04415406
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.6560433
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.90634601
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89730563
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89730563
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89133263
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87110399
15GATA1_19941826_ChIP-Seq_K562_Human1.75499145
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68256498
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63678907
18DROSHA_22980978_ChIP-Seq_HELA_Human1.59720650
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59039171
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.55526679
21EGR1_19032775_ChIP-ChIP_M12_Human1.52673806
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.52470500
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.48355192
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44972427
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43797302
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42961568
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.42339651
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38167815
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37044150
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.36420922
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36354638
32EZH2_22144423_ChIP-Seq_EOC_Human1.33781331
33RNF2_27304074_Chip-Seq_NSC_Mouse1.28054721
34RXR_22108803_ChIP-Seq_LS180_Human1.26061956
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.25028571
36TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22619313
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18386011
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18340615
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18228858
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.16341204
41GBX2_23144817_ChIP-Seq_PC3_Human1.13451243
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13307548
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12694475
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11950542
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.09988117
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08738259
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.07635520
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06554153
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.06543120
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.05745383
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05584268
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04806312
53ER_23166858_ChIP-Seq_MCF-7_Human1.04508607
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02526664
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01343732
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00938417
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.00312312
58DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99983338
59ARNT_22903824_ChIP-Seq_MCF-7_Human0.99903159
60GATA6_21074721_ChIP-Seq_CACO-2_Human0.99743224
61SMAD4_21741376_ChIP-Seq_HESCs_Human0.99623860
62BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98872913
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97952773
64CMYC_18555785_Chip-Seq_ESCs_Mouse0.97286811
65TBL1_22424771_ChIP-Seq_293T_Human0.97168105
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96658123
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94476610
68STAT3_23295773_ChIP-Seq_U87_Human0.93818753
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93272449
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92891828
71BCAT_22108803_ChIP-Seq_LS180_Human0.92380152
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91167613
73PHF8_20622853_ChIP-Seq_HELA_Human0.91166067
74CJUN_26792858_Chip-Seq_BT549_Human0.90568505
75SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87486948
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87453630
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86536995
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86284664
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86236325
80GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85887396
81REST_21632747_ChIP-Seq_MESCs_Mouse0.85620523
82NANOG_16518401_ChIP-PET_MESCs_Mouse0.85322948
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84121794
84CTCF_27219007_Chip-Seq_Bcells_Human0.84002773
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83897462
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83647437
87E2F1_18555785_Chip-Seq_ESCs_Mouse0.83629250
88NMYC_18555785_Chip-Seq_ESCs_Mouse0.83289512
89KLF4_18555785_Chip-Seq_ESCs_Mouse0.82843120
90RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81882782
91EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81882782
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.80666410
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79728432
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79728432
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79728432
96SMAD4_21799915_ChIP-Seq_A2780_Human0.78100484
97RING1B_27294783_Chip-Seq_ESCs_Mouse0.77197694
98ZNF274_21170338_ChIP-Seq_K562_Hela0.76348505
99P53_22387025_ChIP-Seq_ESCs_Mouse0.76258091
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76036165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.68334991
2MP0004130_abnormal_muscle_cell4.96063467
3MP0004264_abnormal_extraembryonic_tissu4.02082077
4MP0003252_abnormal_bile_duct3.59906733
5MP0004133_heterotaxia2.87929575
6MP0002928_abnormal_bile_duct2.71605055
7MP0006072_abnormal_retinal_apoptosis2.47576901
8MP0003329_amyloid_beta_deposits2.39895212
9MP0005448_abnormal_energy_balance2.32211363
10MP0005408_hypopigmentation2.29197583
11MP0002751_abnormal_autonomic_nervous2.23701501
12MP0001270_distended_abdomen2.08838126
13MP0004272_abnormal_basement_membrane2.03800793
14MP0005084_abnormal_gallbladder_morpholo12.5760260
15MP0003943_abnormal_hepatobiliary_system1.76538673
16MP0005379_endocrine/exocrine_gland_phen1.65632258
17MP0005220_abnormal_exocrine_pancreas1.61031703
18MP0000604_amyloidosis1.54517474
19MP0005165_increased_susceptibility_to1.52485232
20MP0001529_abnormal_vocalization1.42065947
21MP0009764_decreased_sensitivity_to1.41830039
22MP0003718_maternal_effect1.40544130
23MP0001958_emphysema1.39604940
24MP0005646_abnormal_pituitary_gland1.14553664
25MP0001905_abnormal_dopamine_level1.04906320
26MP0002909_abnormal_adrenal_gland1.04317094
27MP0000470_abnormal_stomach_morphology1.04174720
28MP0001944_abnormal_pancreas_morphology1.02637071
29MP0002572_abnormal_emotion/affect_behav1.00280217
30MP0000465_gastrointestinal_hemorrhage0.99988533
31MP0008569_lethality_at_weaning0.91000496
32MP0003638_abnormal_response/metabolism_0.89891545
33MP0003121_genomic_imprinting0.81251004
34MP0001915_intracranial_hemorrhage0.79876184
35MP0004019_abnormal_vitamin_homeostasis0.78528620
36MP0008469_abnormal_protein_level0.78383074
37MP0008875_abnormal_xenobiotic_pharmacok0.77126585
38MP0000371_diluted_coat_color0.76861415
39MP0001800_abnormal_humoral_immune0.75780722
40MP0005164_abnormal_response_to0.75564063
41MP0002405_respiratory_system_inflammati0.74167509
42MP0002693_abnormal_pancreas_physiology0.72494829
43MP0000609_abnormal_liver_physiology0.70359988
44MP0005387_immune_system_phenotype0.68550658
45MP0001790_abnormal_immune_system0.68550658
46MP0003866_abnormal_defecation0.67673326
47MP0002098_abnormal_vibrissa_morphology0.66190717
48MP0005253_abnormal_eye_physiology0.65157458
49MP0002078_abnormal_glucose_homeostasis0.64347795
50MP0000703_abnormal_thymus_morphology0.64028408
51MP0003953_abnormal_hormone_level0.62833812
52MP0002136_abnormal_kidney_physiology0.60781845
53MP0001533_abnormal_skeleton_physiology0.58689891
54MP0004947_skin_inflammation0.58133904
55MP0001851_eye_inflammation0.57703207
56MP0002998_abnormal_bone_remodeling0.54656747
57MP0001845_abnormal_inflammatory_respons0.49005191
58MP0009642_abnormal_blood_homeostasis0.47578939
59MP0002722_abnormal_immune_system0.45234653
60MP0003195_calcinosis0.44506223
61MP0005551_abnormal_eye_electrophysiolog0.41338785
62MP0001835_abnormal_antigen_presentation0.39654346
63MP0002822_catalepsy0.39128365
64MP0005334_abnormal_fat_pad0.38162309
65MP0005365_abnormal_bile_salt0.36437438
66MP0002429_abnormal_blood_cell0.36410610
67MP0002419_abnormal_innate_immunity0.36248784
68MP0000477_abnormal_intestine_morphology0.36108297
69MP0002735_abnormal_chemical_nociception0.35409152
70MP0000598_abnormal_liver_morphology0.35295876
71MP0002882_abnormal_neuron_morphology0.34837936
72MP0000920_abnormal_myelination0.34086376
73MP0009931_abnormal_skin_appearance0.34029115
74MP0000759_abnormal_skeletal_muscle0.33972118
75MP0002229_neurodegeneration0.33910264
76MP0002452_abnormal_antigen_presenting0.33619330
77MP0001986_abnormal_taste_sensitivity0.33310141
78MP0004484_altered_response_of0.32719837
79MP0001501_abnormal_sleep_pattern0.32511622
80MP0008004_abnormal_stomach_pH0.32343639
81MP0005423_abnormal_somatic_nervous0.32183405
82MP0005395_other_phenotype0.31955117
83MP0000716_abnormal_immune_system0.30702131
84MP0002420_abnormal_adaptive_immunity0.30636768
85MP0001819_abnormal_immune_cell0.29865224
86MP0005390_skeleton_phenotype0.29475228
87MP0002398_abnormal_bone_marrow0.28744222
88MP0002723_abnormal_immune_serum0.28099196
89MP0001299_abnormal_eye_distance/0.27798995
90MP0001175_abnormal_lung_morphology0.26684818
91MP0005000_abnormal_immune_tolerance0.25839318
92MP0003880_abnormal_central_pattern0.25759300
93MP0006276_abnormal_autonomic_nervous0.24935850
94MP0000689_abnormal_spleen_morphology0.24141711
95MP0002066_abnormal_motor_capabilities/c0.24083046
96MP0002139_abnormal_hepatobiliary_system0.23889027
97MP0002161_abnormal_fertility/fecundity0.22242085
98MP0005645_abnormal_hypothalamus_physiol0.21510225
99MP0005391_vision/eye_phenotype0.20912242
100MP0002128_abnormal_blood_circulation0.20806192

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of dental color (HP:0011073)8.40960816
2Abnormality of renal resorption (HP:0011038)8.08918108
3Osteomalacia (HP:0002749)7.91197831
4Polyuria (HP:0000103)7.63129469
5Abnormality of the dental pulp (HP:0006479)7.47981977
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.83102454
7Abnormal urine output (HP:0012590)6.52561594
8Abnormality of renal excretion (HP:0011036)5.70652772
9Round ear (HP:0100830)5.35974143
10Chronic bronchitis (HP:0004469)4.93463012
11Volvulus (HP:0002580)4.33887007
12Lip pit (HP:0100267)4.27162173
13IgM deficiency (HP:0002850)4.13989728
14Autoimmune thrombocytopenia (HP:0001973)4.04023733
15Toxemia of pregnancy (HP:0100603)3.95404999
16Molar tooth sign on MRI (HP:0002419)3.91007264
17Abnormality of midbrain morphology (HP:0002418)3.91007264
18Nephrocalcinosis (HP:0000121)3.84517127
19Esophageal varix (HP:0002040)3.77737607
20Large earlobe (HP:0009748)3.49300690
21Depressed nasal tip (HP:0000437)3.39592924
22Lipoatrophy (HP:0100578)3.36006159
23Abnormal respiratory motile cilium physiology (HP:0012261)3.35801638
24Rhinitis (HP:0012384)3.33119172
25Sparse lateral eyebrow (HP:0005338)3.30111631
26Tachypnea (HP:0002789)3.25390778
27Drooling (HP:0002307)3.23413489
28Excessive salivation (HP:0003781)3.10022175
29Hypoparathyroidism (HP:0000829)3.08336416
30Intestinal fistula (HP:0100819)2.98318041
31Hyperphosphaturia (HP:0003109)2.96025034
32Thick eyebrow (HP:0000574)2.95725923
33Panhypogammaglobulinemia (HP:0003139)2.94255147
34Personality changes (HP:0000751)2.82433949
35Nephronophthisis (HP:0000090)2.75196995
36Hepatitis (HP:0012115)2.66261757
37Petechiae (HP:0000967)2.63733972
38Abnormal urine phosphate concentration (HP:0012599)2.50930758
39Dilated cardiomyopathy (HP:0001644)2.50306941
40Ureteral stenosis (HP:0000071)2.50188526
41Abnormality of the fingertips (HP:0001211)2.41047709
42Short 5th finger (HP:0009237)2.36189434
43Striae distensae (HP:0001065)2.33840085
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.33628573
45Glycosuria (HP:0003076)2.33257145
46Abnormality of urine glucose concentration (HP:0011016)2.33257145
47Gingival overgrowth (HP:0000212)2.33123670
48Ureteral obstruction (HP:0006000)2.30879485
49Recurrent cutaneous fungal infections (HP:0011370)2.28224377
50Chronic mucocutaneous candidiasis (HP:0002728)2.28224377
51Abnormality of transition element cation homeostasis (HP:0011030)2.26738778
52Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.25240359
53Sudden cardiac death (HP:0001645)2.25009082
54Nephropathy (HP:0000112)2.22332950
55Hypercalciuria (HP:0002150)2.18552042
56Inability to walk (HP:0002540)2.16111483
57Colitis (HP:0002583)2.14950572
58Preauricular pit (HP:0004467)2.13272805
59Periauricular skin pits (HP:0100277)2.13272805
60Decreased muscle mass (HP:0003199)2.13261272
61Bronchitis (HP:0012387)2.09961518
62Recurrent otitis media (HP:0000403)2.06732287
63Abnormality of the renal medulla (HP:0100957)2.04323213
64Abnormality of salivation (HP:0100755)2.03705850
65Agammaglobulinemia (HP:0004432)2.00474936
66Anal stenosis (HP:0002025)2.00406231
67Preauricular skin tag (HP:0000384)2.00378969
68Overgrowth (HP:0001548)12.3210816
69Amelogenesis imperfecta (HP:0000705)11.6510931
70Abnormality of calcium-phosphate metabolism (HP:0100530)10.0242288
71Delayed eruption of teeth (HP:0000684)1.95907206
72Chondrocalcinosis (HP:0000934)1.93082679
73Abnormality of Sharpey fibers (HP:0100685)1.90762829
74Chorioretinal coloboma (HP:0000567)1.90601834
75Ectopic kidney (HP:0000086)1.88232958
76Truncal ataxia (HP:0002078)1.82546618
77Prominent supraorbital ridges (HP:0000336)1.82200688
78Renal tubular dysfunction (HP:0000124)1.77701220
79Stage 5 chronic kidney disease (HP:0003774)1.72588542
80Skin tags (HP:0010609)1.68256980
81Torticollis (HP:0000473)1.67997359
82Limited elbow extension (HP:0001377)1.63825668
83Small hand (HP:0200055)1.62261747
84Abnormality of small intestinal villus morphology (HP:0011472)1.61732160
85Villous atrophy (HP:0011473)1.61732160
86Oculomotor apraxia (HP:0000657)1.61113772
87Blepharitis (HP:0000498)1.58481330
88Palmoplantar keratoderma (HP:0000982)1.55321078
89Ectropion (HP:0000656)1.55080174
90Polyneuropathy (HP:0001271)1.52765175
91Bronchiectasis (HP:0002110)1.51366028
92Highly arched eyebrow (HP:0002553)1.51009806
93Prenatal maternal abnormality (HP:0002686)1.49568720
94Skin pits (HP:0100276)1.45886856
95Aplasia/Hypoplasia of the earlobes (HP:0009906)1.41969707
96Proximal placement of thumb (HP:0009623)1.41355720
97Viral hepatitis (HP:0006562)1.37824960
98Osteoarthritis (HP:0002758)1.35683819
99Mask-like facies (HP:0000298)1.35612402
100Delayed gross motor development (HP:0002194)1.32132126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.59023879
2BLK4.31655330
3STK34.06192113
4RIPK43.11419721
5CDC42BPA2.15431520
6BMPR22.06949358
7NTRK214.2608623
8HIPK21.23669124
9FGFR10.95839521
10ROCK20.78666599
11SYK0.67514008
12SRC0.63715910
13OBSCN0.61529342
14INSRR0.61421029
15PRKCQ0.60650689
16PRKAA10.57307005
17WNK30.56113029
18ROCK10.55891008
19MUSK0.55888242
20GRK10.50273381
21MAP4K20.49821266
22GRK70.47239396
23ADRBK20.46577151
24PRKACG0.44889223
25TIE10.42961355
26ABL10.42386699
27MAPK150.42019756
28TXK0.41442922
29ERBB40.39977191
30PRKACA0.38197782
31PRKACB0.36960776
32SRPK10.34793088
33CAMK2A0.34271595
34PLK10.28894182
35PIK3CG0.26741447
36LYN0.25033951
37PRKCA0.23169610
38TLK10.22348380
39MAPK140.22241309
40GSK3B0.21957383
41MATK0.21719529
42FRK0.21523378
43EPHA40.20948872
44PRKCB0.20715674
45WNK40.20301507
46PLK40.19894678
47RPS6KA30.19569413
48KIT0.18830059
49LMTK20.18008881
50GRK50.17274793
51PHKG10.17083863
52PHKG20.17083863
53FYN0.16865596
54CHUK0.16813614
55MST1R0.16604858
56CSNK1A10.16120191
57KDR0.15704506
58CDK10.15208006
59TTN0.15120508
60TAOK20.15098834
61TEC0.15057666
62OXSR10.14657344
63DDR20.13699750
64CASK0.13500745
65PRKCD0.13353853
66EPHA20.13005506
67ITK0.12556415
68GRK60.11819942
69TNK20.11535012
70TGFBR20.11400173
71ADRBK10.11254311
72PINK10.10637625
73ZAK0.10565713
74LCK0.10431248
75BTK0.10157813
76MAPK90.09923515
77PRKDC0.09723781
78PRKCG0.09618088
79PIM20.09441475
80PKN10.09107495
81MAP2K60.09049056
82IKBKE0.09045393
83STK390.08901514
84IGF1R0.08187723
85CAMK2G0.07184596
86PRKCE0.07080694
87ABL20.06693121
88HCK0.06647621
89EGFR0.06476256
90BMPR1B0.06066867
91MAP2K70.05847065
92PRKG10.05258199
93AKT10.05087217
94PIM10.05006383
95MOS0.04969293
96PIK3CA0.04527970
97IRAK20.03756201
98PAK30.03568811
99INSR0.03248945
100MYLK0.02770430

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.26480230
2Sulfur relay system_Homo sapiens_hsa041223.71288055
3Sulfur metabolism_Homo sapiens_hsa009203.64965293
4Ovarian steroidogenesis_Homo sapiens_hsa049133.37651527
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.21199161
6Linoleic acid metabolism_Homo sapiens_hsa005912.96032621
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.85066141
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.69900221
9Collecting duct acid secretion_Homo sapiens_hsa049662.55685086
10Vibrio cholerae infection_Homo sapiens_hsa051102.40088300
11Bile secretion_Homo sapiens_hsa049762.36696703
12Thyroid hormone synthesis_Homo sapiens_hsa049182.20774170
13Pancreatic secretion_Homo sapiens_hsa049722.20222235
14Fat digestion and absorption_Homo sapiens_hsa049752.12774767
15Salivary secretion_Homo sapiens_hsa049702.11203489
16Gastric acid secretion_Homo sapiens_hsa049712.09109782
17Synaptic vesicle cycle_Homo sapiens_hsa047212.08795687
18Cocaine addiction_Homo sapiens_hsa050301.91618420
19Circadian entrainment_Homo sapiens_hsa047131.85765542
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82031213
21Insulin secretion_Homo sapiens_hsa049111.79542265
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.74240830
23Glutamatergic synapse_Homo sapiens_hsa047241.74143968
24Taste transduction_Homo sapiens_hsa047421.71831541
25GABAergic synapse_Homo sapiens_hsa047271.70975936
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69767594
27Morphine addiction_Homo sapiens_hsa050321.68507328
28Dilated cardiomyopathy_Homo sapiens_hsa054141.63579040
29Ether lipid metabolism_Homo sapiens_hsa005651.62360952
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.61396227
31Gap junction_Homo sapiens_hsa045401.55930264
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53096769
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45356785
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41355841
35Amphetamine addiction_Homo sapiens_hsa050311.40029506
36GnRH signaling pathway_Homo sapiens_hsa049121.37012213
37Melanogenesis_Homo sapiens_hsa049161.33272214
38Arachidonic acid metabolism_Homo sapiens_hsa005901.32482171
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23235852
40Oxytocin signaling pathway_Homo sapiens_hsa049211.18472271
41Cholinergic synapse_Homo sapiens_hsa047251.15238187
42Platelet activation_Homo sapiens_hsa046111.13063637
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12817381
44Estrogen signaling pathway_Homo sapiens_hsa049151.06365614
45Calcium signaling pathway_Homo sapiens_hsa040201.06091197
46Circadian rhythm_Homo sapiens_hsa047100.99443369
47Dorso-ventral axis formation_Homo sapiens_hsa043200.87750548
48Pyruvate metabolism_Homo sapiens_hsa006200.80143457
49Serotonergic synapse_Homo sapiens_hsa047260.79321052
50Oocyte meiosis_Homo sapiens_hsa041140.75546861
51Rheumatoid arthritis_Homo sapiens_hsa053230.74669081
52Chemokine signaling pathway_Homo sapiens_hsa040620.73539487
53ECM-receptor interaction_Homo sapiens_hsa045120.70274427
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62842286
55RNA degradation_Homo sapiens_hsa030180.60141867
56cAMP signaling pathway_Homo sapiens_hsa040240.47001605
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45615519
58Primary immunodeficiency_Homo sapiens_hsa053400.45113893
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.40086500
60Alcoholism_Homo sapiens_hsa050340.38509789
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36894320
62Parkinsons disease_Homo sapiens_hsa050120.35965193
63Dopaminergic synapse_Homo sapiens_hsa047280.34383623
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33650910
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.32336858
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.30239772
67Staphylococcus aureus infection_Homo sapiens_hsa051500.29016557
68Prion diseases_Homo sapiens_hsa050200.27945366
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.24355166
70Purine metabolism_Homo sapiens_hsa002300.23603303
71Rap1 signaling pathway_Homo sapiens_hsa040150.22477484
72Retinol metabolism_Homo sapiens_hsa008300.22008930
73Caffeine metabolism_Homo sapiens_hsa002320.21907563
74Oxidative phosphorylation_Homo sapiens_hsa001900.21501985
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19285529
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.16290705
77Hedgehog signaling pathway_Homo sapiens_hsa043400.16009734
78Phagosome_Homo sapiens_hsa041450.15199003
79Asthma_Homo sapiens_hsa053100.15102574
80Systemic lupus erythematosus_Homo sapiens_hsa053220.14463205
81Glucagon signaling pathway_Homo sapiens_hsa049220.14186911
82Ras signaling pathway_Homo sapiens_hsa040140.12410643
83Tuberculosis_Homo sapiens_hsa051520.11941405
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.11467261
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11214632
86Type I diabetes mellitus_Homo sapiens_hsa049400.10693035
87Nicotine addiction_Homo sapiens_hsa050330.10151672
88HTLV-I infection_Homo sapiens_hsa051660.09819372
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.08473006
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08273194
91Autoimmune thyroid disease_Homo sapiens_hsa053200.07245739
92African trypanosomiasis_Homo sapiens_hsa051430.06688167
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06034418
94Chemical carcinogenesis_Homo sapiens_hsa052040.05798348
95Renin secretion_Homo sapiens_hsa049240.04564303
96Allograft rejection_Homo sapiens_hsa053300.04368749
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.04212318
98Leishmaniasis_Homo sapiens_hsa051400.04101611
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.03699085
100Hematopoietic cell lineage_Homo sapiens_hsa046400.03476694

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