ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	activation of protein kinase A activity (GO:0034199)	9.94897298
2	negative regulation of type 2 immune response (GO:0002829)	9.82992812
3	positive regulation of RNA splicing (GO:0033120)	9.62455668
4	seminiferous tubule development (GO:0072520)	9.57193274
5	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	8.91592731
6	cAMP biosynthetic process (GO:0006171)	8.86426266
7	detection of chemical stimulus involved in sensory perception (GO:0050907)	8.46572012
8	negative regulation of alpha-beta T cell differentiation (GO:0046639)	8.19623130
9	enteric nervous system development (GO:0048484)	7.80008722
10	regulation of protein sumoylation (GO:0033233)	7.27373004
11	synaptic transmission, dopaminergic (GO:0001963)	7.15978782
12	dendritic spine morphogenesis (GO:0060997)	7.00997831
13	positive regulation of mitochondrial fission (GO:0090141)	6.82853488
14	righting reflex (GO:0060013)	6.79352125
15	heterotypic cell-cell adhesion (GO:0034113)	6.34122848
16	positive regulation of T-helper 1 type immune response (GO:0002827)	6.22381115
17	detection of chemical stimulus (GO:0009593)	6.08064184
18	endothelial cell differentiation (GO:0045446)	5.99487290
19	arachidonic acid secretion (GO:0050482)	5.95683161
20	icosanoid secretion (GO:0032309)	5.95683161
21	positive regulation of T-helper cell differentiation (GO:0045624)	5.78493280
22	hepatocyte apoptotic process (GO:0097284)	5.77981510
23	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.58388653
24	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.24296878
25	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	5.13802619
26	drug transmembrane transport (GO:0006855)	5.10189069
27	regulation of mitochondrial fission (GO:0090140)	5.09882946
28	neuronal ion channel clustering (GO:0045161)	4.94532004
29	icosanoid transport (GO:0071715)	4.91842372
30	fatty acid derivative transport (GO:1901571)	4.91842372
31	neural tube formation (GO:0001841)	4.83975166
32	chemosensory behavior (GO:0007635)	4.73681152
33	negative regulation of alpha-beta T cell activation (GO:0046636)	4.69955715
34	cilium or flagellum-dependent cell motility (GO:0001539)	4.63835743
35	hyaluronan catabolic process (GO:0030214)	4.58592413
36	embryonic digestive tract morphogenesis (GO:0048557)	4.53168491
37	nephron tubule morphogenesis (GO:0072078)	4.49882897
38	nephron epithelium morphogenesis (GO:0072088)	4.49882897
39	cyclic purine nucleotide metabolic process (GO:0052652)	4.46218704
40	regulation of T-helper 1 type immune response (GO:0002825)	4.45397472
41	positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	4.36886300
42	retina layer formation (GO:0010842)	4.33092461
43	cyclic nucleotide biosynthetic process (GO:0009190)	4.32369854
44	positive regulation of membrane potential (GO:0045838)	4.29363908
45	vocalization behavior (GO:0071625)	4.28823449
46	ATP hydrolysis coupled proton transport (GO:0015991)	4.24458052
47	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	4.24458052
48	protein localization to synapse (GO:0035418)	4.23198366
49	attachment of spindle microtubules to kinetochore (GO:0008608)	4.21759448
50	regulation of T-helper cell differentiation (GO:0045622)	4.17527342
51	regulation of cAMP-mediated signaling (GO:0043949)	4.13333722
52	cellular response to glucagon stimulus (GO:0071377)	4.12019039
53	response to dietary excess (GO:0002021)	4.11819584
54	regulation of type 2 immune response (GO:0002828)	4.07888407
55	negative regulation of actin filament bundle assembly (GO:0032232)	4.06383187
56	water transport (GO:0006833)	4.04965525
57	cAMP metabolic process (GO:0046058)	4.01177865
58	dendritic spine organization (GO:0097061)	3.94882325
59	pre-miRNA processing (GO:0031054)	3.92145056
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.87899104
61	mitochondrial fusion (GO:0008053)	3.84442638
62	positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	3.82841857
63	cellular zinc ion homeostasis (GO:0006882)	3.73236122
64	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.72370876
65	negative regulation of T cell differentiation (GO:0045581)	3.69074094
66	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.68579853
67	monoamine transport (GO:0015844)	3.65196727
68	fluid transport (GO:0042044)	3.63713872
69	cellular response to ATP (GO:0071318)	3.62896358
70	positive regulation of protein targeting to membrane (GO:0090314)	3.56126075
71	drug transport (GO:0015893)	3.49390968
72	leukotriene biosynthetic process (GO:0019370)	3.47250326
73	negative regulation of homotypic cell-cell adhesion (GO:0034111)	3.43962902
74	sulfur amino acid catabolic process (GO:0000098)	3.42294430
75	left/right axis specification (GO:0070986)	3.41330242
76	sequestering of metal ion (GO:0051238)	3.31703548
77	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.29629191
78	positive regulation of alpha-beta T cell differentiation (GO:0046638)	3.26033726
79	regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)	3.25863557
80	negative regulation of astrocyte differentiation (GO:0048712)	3.25029869
81	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.21891380
82	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.21379851
83	neurofilament cytoskeleton organization (GO:0060052)	3.20595344
84	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.20510499
85	renal tubule morphogenesis (GO:0061333)	3.18903549
86	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.18163557
87	neuromuscular process controlling posture (GO:0050884)	3.17793319
88	adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)	3.14226911
89	positive regulation of steroid hormone secretion (GO:2000833)	3.08047568
90	reflex (GO:0060004)	3.04882210
91	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)	3.03697902
92	response to glucagon (GO:0033762)	3.03087872
93	tooth mineralization (GO:0034505)	14.2622224
94	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	13.6297296
95	positive regulation of protein sumoylation (GO:0033235)	11.6436114
96	negative regulation of T-helper cell differentiation (GO:0045623)	11.1132631
97	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	11.1132631
98	protein K11-linked deubiquitination (GO:0035871)	10.7818940
99	regulation of T-helper 2 cell differentiation (GO:0045628)	10.0955363
100	regulation of T-helper 1 cell differentiation (GO:0045625)	10.0649898

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.61160496
2	EGR1_19374776_ChIP-ChIP_THP-1_Human	4.97274867
3	AR_21572438_ChIP-Seq_LNCaP_Human	4.68577494
4	IGF1R_20145208_ChIP-Seq_DFB_Human	4.48243629
5	VDR_22108803_ChIP-Seq_LS180_Human	4.40357797
6	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	3.27385963
7	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.08704318
8	TP53_16413492_ChIP-PET_HCT116_Human	2.08046304
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	10.3620735
10	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.95784849
11	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.94310717
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93029383
13	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.92720013
14	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.89539140
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89539140
16	GATA1_19941826_ChIP-Seq_K562_Human	1.77349685
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.76072086
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71705179
19	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.69216553
20	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.59175646
21	EGR1_19032775_ChIP-ChIP_M12_Human	1.58573532
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.55572731
23	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.55004289
24	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50996575
25	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.48668059
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42756671
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41260160
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.40620900
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40575245
30	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37119188
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.35025050
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.32308361
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29713870
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29574948
35	RXR_22108803_ChIP-Seq_LS180_Human	1.27790906
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.25480881
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23983849
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.23709718
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22972442
40	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.21575451
41	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20581739
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18840762
43	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.18488817
44	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.18178845
45	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.17647002
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13980224
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13608461
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11384712
49	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.10109078
50	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.09091857
51	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.08721443
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05967635
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04689393
54	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.02946420
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.01505578
56	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.01270800
57	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01132717
58	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.00809137
59	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.00805180
60	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00358518
61	CTCF_27219007_Chip-Seq_Bcells_Human	0.98957300
62	GBX2_23144817_ChIP-Seq_PC3_Human	0.98119926
63	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97644194
64	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.97436519
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96941018
66	TBL1_22424771_ChIP-Seq_293T_Human	0.96446177
67	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.95777720
68	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.95777720
69	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95756567
70	BCAT_22108803_ChIP-Seq_LS180_Human	0.95033005
71	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.93225469
72	STAT3_23295773_ChIP-Seq_U87_Human	0.93112885
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.92360499
74	PHF8_20622853_ChIP-Seq_HELA_Human	0.92000667
75	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.90791342
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.90643763
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89647186
78	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88732145
79	CJUN_26792858_Chip-Seq_BT549_Human	0.88299283
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88044873
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.88044873
82	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.88031077
83	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.87521218
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.86920697
85	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.85918014
86	ZNF274_21170338_ChIP-Seq_K562_Hela	0.85714422
87	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.85286944
88	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84919333
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.83346768
90	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.82709297
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.82449543
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.81014494
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.80827672
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.80135949
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.79910103
96	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.79415755
97	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.78598504
98	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.78070748
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.76784353
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.76435858

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008961_abnormal_basal_metabolism	9.62972721
2	MP0004130_abnormal_muscle_cell	4.88277983
3	MP0004264_abnormal_extraembryonic_tissu	3.75077978
4	MP0003252_abnormal_bile_duct	3.71062998
5	MP0004133_heterotaxia	2.91803219
6	MP0002928_abnormal_bile_duct	2.81367531
7	MP0006072_abnormal_retinal_apoptosis	2.65016797
8	MP0002751_abnormal_autonomic_nervous	2.32372788
9	MP0005448_abnormal_energy_balance	2.26716283
10	MP0001270_distended_abdomen	2.13305622
11	MP0005408_hypopigmentation	2.12090864
12	MP0005084_abnormal_gallbladder_morpholo	12.5153987
13	MP0004272_abnormal_basement_membrane	1.94591447
14	MP0003329_amyloid_beta_deposits	1.94556715
15	MP0005379_endocrine/exocrine_gland_phen	1.78380695
16	MP0003943_abnormal_hepatobiliary_system	1.61980207
17	MP0005220_abnormal_exocrine_pancreas	1.61704649
18	MP0005165_increased_susceptibility_to	1.47285528
19	MP0009764_decreased_sensitivity_to	1.45437972
20	MP0001958_emphysema	1.38817029
21	MP0001529_abnormal_vocalization	1.38388288
22	MP0003718_maternal_effect	1.29349679
23	MP0000604_amyloidosis	1.20036371
24	MP0005646_abnormal_pituitary_gland	1.10281520
25	MP0001944_abnormal_pancreas_morphology	1.06562082
26	MP0002572_abnormal_emotion/affect_behav	1.03951423
27	MP0001905_abnormal_dopamine_level	1.03692025
28	MP0000470_abnormal_stomach_morphology	1.03334087
29	MP0003121_genomic_imprinting	1.01027748
30	MP0002909_abnormal_adrenal_gland	0.99540099
31	MP0003638_abnormal_response/metabolism_	0.96378960
32	MP0008569_lethality_at_weaning	0.84661706
33	MP0005253_abnormal_eye_physiology	0.82836462
34	MP0002098_abnormal_vibrissa_morphology	0.80702483
35	MP0004019_abnormal_vitamin_homeostasis	0.79123955
36	MP0000465_gastrointestinal_hemorrhage	0.78700486
37	MP0000371_diluted_coat_color	0.75937704
38	MP0008875_abnormal_xenobiotic_pharmacok	0.74967437
39	MP0008469_abnormal_protein_level	0.72067840
40	MP0005164_abnormal_response_to	0.71041124
41	MP0002693_abnormal_pancreas_physiology	0.70705713
42	MP0003195_calcinosis	0.70288042
43	MP0002405_respiratory_system_inflammati	0.68021740
44	MP0001915_intracranial_hemorrhage	0.65717833
45	MP0003866_abnormal_defecation	0.64883321
46	MP0005551_abnormal_eye_electrophysiolog	0.64726718
47	MP0001800_abnormal_humoral_immune	0.64718811
48	MP0000609_abnormal_liver_physiology	0.63163006
49	MP0003953_abnormal_hormone_level	0.62959226
50	MP0002078_abnormal_glucose_homeostasis	0.62847504
51	MP0009053_abnormal_anal_canal	0.62271092
52	MP0002136_abnormal_kidney_physiology	0.61942593
53	MP0001533_abnormal_skeleton_physiology	0.59685239
54	MP0000703_abnormal_thymus_morphology	0.57873476
55	MP0002735_abnormal_chemical_nociception	0.56261197
56	MP0002998_abnormal_bone_remodeling	0.54460124
57	MP0001790_abnormal_immune_system	0.52223008
58	MP0005387_immune_system_phenotype	0.52223008
59	MP0005377_hearing/vestibular/ear_phenot	0.51559707
60	MP0003878_abnormal_ear_physiology	0.51559707
61	MP0006276_abnormal_autonomic_nervous	0.47145200
62	MP0009642_abnormal_blood_homeostasis	0.46984585
63	MP0001851_eye_inflammation	0.46504560
64	MP0003880_abnormal_central_pattern	0.46238644
65	MP0004947_skin_inflammation	0.46120379
66	MP0005423_abnormal_somatic_nervous	0.44240739
67	MP0005360_urolithiasis	0.43658111
68	MP0001968_abnormal_touch/_nociception	0.43397942
69	MP0002822_catalepsy	0.42556815
70	MP0002736_abnormal_nociception_after	0.41329935
71	MP0002882_abnormal_neuron_morphology	0.41189938
72	MP0002249_abnormal_larynx_morphology	0.40490912
73	MP0005410_abnormal_fertilization	0.40198013
74	MP0001845_abnormal_inflammatory_respons	0.39566052
75	MP0005395_other_phenotype	0.39305226
76	MP0005334_abnormal_fat_pad	0.39004340
77	MP0005365_abnormal_bile_salt	0.38573700
78	MP0002722_abnormal_immune_system	0.37534813
79	MP0008004_abnormal_stomach_pH	0.37140042
80	MP0001501_abnormal_sleep_pattern	0.36744540
81	MP0001986_abnormal_taste_sensitivity	0.35290730
82	MP0002161_abnormal_fertility/fecundity	0.34486488
83	MP0002229_neurodegeneration	0.33985391
84	MP0003136_yellow_coat_color	0.33865965
85	MP0005390_skeleton_phenotype	0.31180232
86	MP0000759_abnormal_skeletal_muscle	0.30408759
87	MP0005195_abnormal_posterior_eye	0.30215066
88	MP0000598_abnormal_liver_morphology	0.29035892
89	MP0002429_abnormal_blood_cell	0.28650769
90	MP0005391_vision/eye_phenotype	0.28468981
91	MP0000477_abnormal_intestine_morphology	0.27330452
92	MP0009931_abnormal_skin_appearance	0.27085094
93	MP0000920_abnormal_myelination	0.26361189
94	MP0001175_abnormal_lung_morphology	0.25992427
95	MP0005636_abnormal_mineral_homeostasis	0.25123810
96	MP0004484_altered_response_of	0.24803366
97	MP0001299_abnormal_eye_distance/	0.24797670
98	MP0002066_abnormal_motor_capabilities/c	0.24794644
99	MP0002419_abnormal_innate_immunity	0.24587363
100	MP0002452_abnormal_antigen_presenting	0.23633809

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of calcium-phosphate metabolism (HP:0100530)	9.70681905
2	Abnormality of renal resorption (HP:0011038)	8.02148959
3	Abnormality of dental color (HP:0011073)	7.91619441
4	Osteomalacia (HP:0002749)	7.64811945
5	Polyuria (HP:0000103)	7.44013591
6	Abnormality of the dental pulp (HP:0006479)	7.23944390
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.93290920
8	Abnormal urine output (HP:0012590)	6.39589156
9	Abnormality of renal excretion (HP:0011036)	5.57938003
10	Volvulus (HP:0002580)	5.27011233
11	Chronic bronchitis (HP:0004469)	5.21796722
12	Round ear (HP:0100830)	5.07359673
13	Lip pit (HP:0100267)	4.30530677
14	Autoimmune thrombocytopenia (HP:0001973)	4.10819087
15	IgM deficiency (HP:0002850)	3.98894112
16	Abnormality of midbrain morphology (HP:0002418)	3.92601803
17	Molar tooth sign on MRI (HP:0002419)	3.92601803
18	Nephrocalcinosis (HP:0000121)	3.85027620
19	Toxemia of pregnancy (HP:0100603)	3.69991731
20	Abnormal respiratory motile cilium physiology (HP:0012261)	3.56450907
21	Esophageal varix (HP:0002040)	3.49199751
22	Depressed nasal tip (HP:0000437)	3.40475612
23	Rhinitis (HP:0012384)	3.39847391
24	Large earlobe (HP:0009748)	3.38745179
25	Intestinal fistula (HP:0100819)	3.34805507
26	Sparse lateral eyebrow (HP:0005338)	3.27266097
27	Lipoatrophy (HP:0100578)	3.15541112
28	Hypoparathyroidism (HP:0000829)	3.10616714
29	Tachypnea (HP:0002789)	3.09131009
30	Hyperphosphaturia (HP:0003109)	3.04295234
31	Thick eyebrow (HP:0000574)	2.98260952
32	Drooling (HP:0002307)	2.97986766
33	Abnormality of the fingertips (HP:0001211)	2.88532975
34	Excessive salivation (HP:0003781)	2.84416037
35	Panhypogammaglobulinemia (HP:0003139)	2.75184589
36	Nephronophthisis (HP:0000090)	2.73897361
37	Personality changes (HP:0000751)	2.58246933
38	Abnormal urine phosphate concentration (HP:0012599)	2.57784971
39	Ureteral stenosis (HP:0000071)	2.56470639
40	Abnormality of urine glucose concentration (HP:0011016)	2.55892302
41	Glycosuria (HP:0003076)	2.55892302
42	Short 5th finger (HP:0009237)	2.55555181
43	Petechiae (HP:0000967)	2.45154252
44	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.42847055
45	Ureteral obstruction (HP:0006000)	2.35256197
46	Dilated cardiomyopathy (HP:0001644)	2.32706638
47	Hypercalciuria (HP:0002150)	2.31586162
48	Preauricular pit (HP:0004467)	2.31487153
49	Periauricular skin pits (HP:0100277)	2.31487153
50	Hepatitis (HP:0012115)	2.30251047
51	Nephropathy (HP:0000112)	2.20208536
52	Bronchitis (HP:0012387)	2.18347178
53	Gingival overgrowth (HP:0000212)	2.17820638
54	Abnormality of transition element cation homeostasis (HP:0011030)	2.17119696
55	Striae distensae (HP:0001065)	2.12552151
56	Recurrent otitis media (HP:0000403)	2.08812603
57	Sudden cardiac death (HP:0001645)	2.08497587
58	Chorioretinal coloboma (HP:0000567)	2.08295709
59	Inability to walk (HP:0002540)	2.08228273
60	Anal stenosis (HP:0002025)	2.07553124
61	Ectopic kidney (HP:0000086)	2.02454132
62	Abnormality of the renal medulla (HP:0100957)	2.01952765
63	Prominent supraorbital ridges (HP:0000336)	2.01796685
64	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.01226700
65	Overgrowth (HP:0001548)	11.5845642
66	Amelogenesis imperfecta (HP:0000705)	11.2585290
67	Recurrent cutaneous fungal infections (HP:0011370)	1.98762990
68	Chronic mucocutaneous candidiasis (HP:0002728)	1.98762990
69	Limited elbow extension (HP:0001377)	1.95055299
70	Preauricular skin tag (HP:0000384)	1.93697707
71	Delayed eruption of teeth (HP:0000684)	1.93082734
72	Colitis (HP:0002583)	1.92850065
73	Blepharitis (HP:0000498)	1.89863143
74	Decreased muscle mass (HP:0003199)	1.84129386
75	Proximal placement of thumb (HP:0009623)	1.82663203
76	Renal tubular dysfunction (HP:0000124)	1.81558556
77	Abnormality of salivation (HP:0100755)	1.79581700
78	Agammaglobulinemia (HP:0004432)	1.77458351
79	Stage 5 chronic kidney disease (HP:0003774)	1.75435954
80	Chondrocalcinosis (HP:0000934)	1.74348670
81	Abnormality of Sharpey fibers (HP:0100685)	1.69786628
82	Small hand (HP:0200055)	1.67431004
83	Truncal ataxia (HP:0002078)	1.64742061
84	Bronchiectasis (HP:0002110)	1.63326710
85	Highly arched eyebrow (HP:0002553)	1.62913005
86	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.61905404
87	Skin tags (HP:0010609)	1.61499428
88	Ectropion (HP:0000656)	1.58469787
89	Deviation of the thumb (HP:0009603)	1.57576907
90	Truncal obesity (HP:0001956)	1.57127558
91	Oculomotor apraxia (HP:0000657)	1.56613241
92	Long palpebral fissure (HP:0000637)	1.53210073
93	Skin pits (HP:0100276)	1.51736631
94	Torticollis (HP:0000473)	1.50692691
95	Increased nuchal translucency (HP:0010880)	1.48605813
96	Palmoplantar keratoderma (HP:0000982)	1.45983132
97	Mask-like facies (HP:0000298)	1.43681070
98	Polyneuropathy (HP:0001271)	1.41858919
99	Abnormality of small intestinal villus morphology (HP:0011472)	1.41159346
100	Villous atrophy (HP:0011473)	1.41159346

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K1	5.22314488
2	BLK	4.17571368
3	MAP2K7	4.14448934
4	STK3	3.78844856
5	MAP3K9	3.09358327
6	RIPK4	2.96948918
7	CDC42BPA	2.15750105
8	NTRK2	13.9562645
9	BMPR2	1.80560353
10	MARK1	1.45541985
11	HIPK2	1.13635267
12	PIK3CG	0.98494832
13	FGFR1	0.84285603
14	INSRR	0.76508562
15	CASK	0.76034713
16	TAF1	0.73682839
17	GRK1	0.73363234
18	MAP4K2	0.72041428
19	ROCK2	0.68992753
20	DDR2	0.67626036
21	OBSCN	0.58203443
22	PLK4	0.58168735
23	SYK	0.55842161
24	ADRBK2	0.55405539
25	SRC	0.54445305
26	PRKCQ	0.54358003
27	MUSK	0.54001064
28	PRKAA1	0.53712145
29	WNK3	0.49940324
30	MAPK15	0.49794406
31	ROCK1	0.47426219
32	PRKACG	0.42534473
33	MATK	0.42333026
34	GRK7	0.40275460
35	ABL1	0.38107701
36	PRKACB	0.38041347
37	PRKACA	0.37767019
38	TIE1	0.36208611
39	TXK	0.32134254
40	SRPK1	0.31987088
41	PLK1	0.30420563
42	CAMK2A	0.28967658
43	GSK3B	0.25838944
44	RPS6KA3	0.23670780
45	ERBB4	0.23595328
46	MOS	0.23238568
47	MAPK14	0.22180307
48	PRKCA	0.21790841
49	GRK5	0.21754337
50	PRKCB	0.21252794
51	WNK4	0.19489237
52	LYN	0.18032681
53	CDK1	0.16426617
54	MAPK4	0.16350372
55	FYN	0.16137679
56	TLK1	0.15513657
57	MAPKAPK5	0.15374277
58	PRKCG	0.15049962
59	AURKA	0.14698456
60	PRKCD	0.14095736
61	CHUK	0.13942481
62	AKT3	0.13700411
63	PNCK	0.13330124
64	PRKDC	0.13098351
65	MST1R	0.13017877
66	GRK6	0.12908148
67	CSNK1A1	0.12710449
68	ARAF	0.12574612
69	KDR	0.12088419
70	TEC	0.11072407
71	ADRBK1	0.10644163
72	VRK1	0.10588763
73	OXSR1	0.10557752
74	PKN1	0.10356233
75	EPHA4	0.10330333
76	PRKG1	0.09719504
77	MAPK9	0.09231966
78	PHKG2	0.08952217
79	PHKG1	0.08952217
80	KIT	0.08585630
81	TNIK	0.07412632
82	FRK	0.07363187
83	BMPR1B	0.06533593
84	TTN	0.06251251
85	PINK1	0.05595356
86	LMTK2	0.05290644
87	ITK	0.05158739
88	ZAK	0.04769826
89	TNK2	0.04721773
90	PIM2	0.04412134
91	AKT1	0.03987468
92	ABL2	0.03646689
93	MAP2K6	0.02767241
94	VRK2	0.02634380
95	CDK7	0.02175623
96	PLK2	0.01443169
97	CDK9	0.00902367
98	CDK2	0.00653948
99	IGF1R	0.00628591
100	LCK	0.00064509

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	5.29644212
2	Sulfur metabolism_Homo sapiens_hsa00920	3.67043015
3	Sulfur relay system_Homo sapiens_hsa04122	3.63381142
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.37170052
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.35322987
6	Linoleic acid metabolism_Homo sapiens_hsa00591	3.10203147
7	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	2.83003595
8	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.64879902
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.43723189
10	Bile secretion_Homo sapiens_hsa04976	2.36912341
11	Vibrio cholerae infection_Homo sapiens_hsa05110	2.27530045
12	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.22393300
13	Fat digestion and absorption_Homo sapiens_hsa04975	2.22150556
14	Pancreatic secretion_Homo sapiens_hsa04972	2.18009126
15	Salivary secretion_Homo sapiens_hsa04970	2.12905550
16	Gastric acid secretion_Homo sapiens_hsa04971	2.06409218
17	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.95346964
18	Cocaine addiction_Homo sapiens_hsa05030	1.92642675
19	Taste transduction_Homo sapiens_hsa04742	1.85593220
20	Circadian entrainment_Homo sapiens_hsa04713	1.81443637
21	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.81087678
22	Insulin secretion_Homo sapiens_hsa04911	1.78007503
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.76284900
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.71290166
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.70580483
26	Morphine addiction_Homo sapiens_hsa05032	1.69026693
27	GABAergic synapse_Homo sapiens_hsa04727	1.68108866
28	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.60936212
29	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.57684088
30	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.55221600
31	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.54077193
32	Gap junction_Homo sapiens_hsa04540	1.52080445
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.41943932
34	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.40398055
35	Melanogenesis_Homo sapiens_hsa04916	1.38474866
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36671653
37	Amphetamine addiction_Homo sapiens_hsa05031	1.32935334
38	GnRH signaling pathway_Homo sapiens_hsa04912	1.31786398
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.22327114
40	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.15047813
41	Cholinergic synapse_Homo sapiens_hsa04725	1.14853263
42	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.13286059
43	Calcium signaling pathway_Homo sapiens_hsa04020	1.10824990
44	Platelet activation_Homo sapiens_hsa04611	1.10192358
45	Estrogen signaling pathway_Homo sapiens_hsa04915	1.03762461
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.93916614
47	Circadian rhythm_Homo sapiens_hsa04710	0.85772915
48	Oocyte meiosis_Homo sapiens_hsa04114	0.83992548
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81910369
50	Serotonergic synapse_Homo sapiens_hsa04726	0.79176121
51	ECM-receptor interaction_Homo sapiens_hsa04512	0.72629672
52	Chemokine signaling pathway_Homo sapiens_hsa04062	0.68677906
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60991302
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.59335180
55	Parkinsons disease_Homo sapiens_hsa05012	0.58612027
56	RNA degradation_Homo sapiens_hsa03018	0.55426216
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.47510816
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.46174785
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40198981
60	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.39981356
61	Alcoholism_Homo sapiens_hsa05034	0.39072254
62	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.36888833
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36691936
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33940298
65	Prion diseases_Homo sapiens_hsa05020	0.33822757
66	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.33812467
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31265873
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.30926083
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30341226
70	Purine metabolism_Homo sapiens_hsa00230	0.29474242
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.27711162
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.27058592
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.24802094
74	Retinol metabolism_Homo sapiens_hsa00830	0.23670680
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.19630761
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.19205667
77	Nicotine addiction_Homo sapiens_hsa05033	0.18299077
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.17292533
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.16398869
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.15422251
81	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.14522769
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.14497088
83	Type I diabetes mellitus_Homo sapiens_hsa04940	0.13011156
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.13010018
85	Caffeine metabolism_Homo sapiens_hsa00232	0.10401642
86	Phagosome_Homo sapiens_hsa04145	0.09065604
87	Glucagon signaling pathway_Homo sapiens_hsa04922	0.07905017
88	HTLV-I infection_Homo sapiens_hsa05166	0.07872597
89	Ras signaling pathway_Homo sapiens_hsa04014	0.07131129
90	Tuberculosis_Homo sapiens_hsa05152	0.03955632
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.03093567
92	African trypanosomiasis_Homo sapiens_hsa05143	0.02156353
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.01687593
94	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.00711021
95	Leishmaniasis_Homo sapiens_hsa05140	0.00248628
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.00118362
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.00043819
98	Renin secretion_Homo sapiens_hsa04924	-0.0178217
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	-0.0090840
100	Asthma_Homo sapiens_hsa05310	-0.0071682

OR7E21P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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