ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium movement (GO:0003341)	9.54716300
2	cilium or flagellum-dependent cell motility (GO:0001539)	9.36555430
3	epithelial cilium movement (GO:0003351)	9.04705497
4	positive regulation of respiratory burst (GO:0060267)	7.18501031
5	oligosaccharide biosynthetic process (GO:0009312)	6.45203234
6	regulation of cilium movement (GO:0003352)	6.31654972
7	response to acidic pH (GO:0010447)	6.27901583
8	axoneme assembly (GO:0035082)	6.12303239
9	opsonization (GO:0008228)	5.33040132
10	intraciliary transport (GO:0042073)	5.18707123
11	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	4.79357024
12	detection of temperature stimulus involved in sensory perception (GO:0050961)	4.79357024
13	left/right pattern formation (GO:0060972)	4.71574886
14	vitamin transmembrane transport (GO:0035461)	4.62290981
15	terpenoid biosynthetic process (GO:0016114)	4.57649048
16	keratinocyte development (GO:0003334)	4.54855148
17	microtubule bundle formation (GO:0001578)	4.40762176
18	positive regulation of macrophage activation (GO:0043032)	4.37602613
19	diterpenoid biosynthetic process (GO:0016102)	4.33825848
20	cellular biogenic amine catabolic process (GO:0042402)	4.22514514
21	amine catabolic process (GO:0009310)	4.22514514
22	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	4.11551920
23	regulation of respiratory burst (GO:0060263)	4.10345872
24	fibroblast migration (GO:0010761)	4.02271869
25	response to xenobiotic stimulus (GO:0009410)	4.01134719
26	primary alcohol catabolic process (GO:0034310)	4.00301271
27	iron coordination entity transport (GO:1901678)	3.94318571
28	negative regulation of T cell differentiation in thymus (GO:0033085)	3.93871774
29	organic cation transport (GO:0015695)	3.93563695
30	leukocyte migration involved in inflammatory response (GO:0002523)	3.86736567
31	protein polyglutamylation (GO:0018095)	3.83192763
32	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.83109444
33	left/right axis specification (GO:0070986)	3.82413318
34	cilium organization (GO:0044782)	3.81901113
35	transepithelial transport (GO:0070633)	3.77069371
36	cilium assembly (GO:0042384)	3.75146866
37	sperm capacitation (GO:0048240)	3.73405158
38	lung epithelium development (GO:0060428)	3.69308120
39	cilium morphogenesis (GO:0060271)	3.66059330
40	regulation of microtubule-based movement (GO:0060632)	3.63714496
41	ethanol metabolic process (GO:0006067)	3.61039462
42	regulation of glycogen (starch) synthase activity (GO:2000465)	3.54296630
43	detection of temperature stimulus (GO:0016048)	3.49038771
44	interferon-gamma secretion (GO:0072643)	3.47293244
45	detection of molecule of bacterial origin (GO:0032490)	3.39868318
46	ventricular system development (GO:0021591)	3.38652688
47	polyamine biosynthetic process (GO:0006596)	3.36602106
48	nephron tubule formation (GO:0072079)	3.35535925
49	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.32568415
50	positive regulation of protein targeting to membrane (GO:0090314)	3.32329901
51	response to pH (GO:0009268)	3.31773085
52	positive regulation of toll-like receptor signaling pathway (GO:0034123)	3.30040628
53	retinoic acid metabolic process (GO:0042573)	3.27233276
54	toxin transport (GO:1901998)	3.23589212
55	retinol metabolic process (GO:0042572)	3.22674653
56	kynurenine metabolic process (GO:0070189)	3.21199106
57	retinal metabolic process (GO:0042574)	3.20857965
58	one-carbon compound transport (GO:0019755)	3.18350611
59	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.15806005
60	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.11755860
61	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	3.06194625
62	phosphatidylcholine biosynthetic process (GO:0006656)	3.02182307
63	positive regulation of action potential (GO:0045760)	3.01682193
64	microtubule-based movement (GO:0007018)	2.98034556
65	tryptophan catabolic process (GO:0006569)	2.97916298
66	indole-containing compound catabolic process (GO:0042436)	2.97916298
67	indolalkylamine catabolic process (GO:0046218)	2.97916298
68	nucleoside diphosphate phosphorylation (GO:0006165)	2.96762805
69	glutathione biosynthetic process (GO:0006750)	2.88948921
70	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.88904228
71	establishment of tissue polarity (GO:0007164)	2.86640894
72	establishment of planar polarity (GO:0001736)	2.86640894
73	cellular component assembly involved in morphogenesis (GO:0010927)	2.81657048
74	primary alcohol metabolic process (GO:0034308)	2.78872626
75	glucosamine-containing compound catabolic process (GO:1901072)	2.75344547
76	membrane repolarization during action potential (GO:0086011)	2.74329035
77	fusion of sperm to egg plasma membrane (GO:0007342)	2.74191737
78	glomerular epithelial cell development (GO:0072310)	2.73039299
79	polyamine metabolic process (GO:0006595)	2.72816085
80	peptidyl-cysteine modification (GO:0018198)	2.72174526
81	pyrimidine dimer repair (GO:0006290)	2.68760132
82	drug catabolic process (GO:0042737)	2.68313485
83	cell projection assembly (GO:0030031)	2.67874760
84	ethanol oxidation (GO:0006069)	2.66997768
85	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.66342849
86	positive regulation of heat generation (GO:0031652)	2.63230247
87	estrogen metabolic process (GO:0008210)	2.63194636
88	microtubule depolymerization (GO:0007019)	2.62323629
89	benzene-containing compound metabolic process (GO:0042537)	2.60389179
90	centriole assembly (GO:0098534)	2.58286716
91	nonribosomal peptide biosynthetic process (GO:0019184)	2.57457749
92	coenzyme catabolic process (GO:0009109)	2.56667825
93	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.53970338
94	regulation of integrin-mediated signaling pathway (GO:2001044)	2.49385678
95	regulation of germinal center formation (GO:0002634)	2.47952480
96	ear development (GO:0043583)	2.47665500
97	norepinephrine metabolic process (GO:0042415)	2.46815738
98	axonemal dynein complex assembly (GO:0070286)	13.7173077
99	motile cilium assembly (GO:0044458)	10.7375833
100	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	10.5143959

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.43590342
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.09805537
3	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.38673035
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.80563266
5	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.63598540
6	VDR_22108803_ChIP-Seq_LS180_Human	2.56535049
7	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.52936818
8	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.38809802
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32037176
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.31442175
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.30462740
12	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.28570088
13	FOXM1_26456572_ChIP-Seq_MCF-7_Human	2.24715549
14	AHR_22903824_ChIP-Seq_MCF-7_Human	2.20164973
15	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.88651462
16	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.84965186
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.81133221
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78255517
19	SOX2_20726797_ChIP-Seq_SW620_Human	1.75873538
20	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.72823623
21	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.68624015
22	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.58244476
23	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.56420859
24	ETV1_20927104_ChIP-Seq_GIST48_Human	1.51786835
25	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.49186248
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.48918864
27	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.48793260
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.42795983
29	PHF8_20622853_ChIP-Seq_HELA_Human	1.41515452
30	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.39592041
31	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.37730111
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33363630
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33363630
34	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.33044895
35	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.29741853
36	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.29306862
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29142710
38	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.28808146
39	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.26635862
40	GATA4_25053715_ChIP-Seq_YYC3_Human	1.26288176
41	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.26245877
42	AR_25329375_ChIP-Seq_VCAP_Human	1.24295269
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23136694
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22834165
45	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.22562847
46	RBPJ_21746931_ChIP-Seq_IB4_Human	1.22132167
47	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.22118928
48	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.21343671
49	DROSHA_22980978_ChIP-Seq_HELA_Human	1.20981187
50	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.19896875
51	IGF1R_20145208_ChIP-Seq_DFB_Human	1.19243565
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.18424088
53	TBL1_22424771_ChIP-Seq_293T_Human	1.17653030
54	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.16732900
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16120520
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.15775623
57	TP63_23658742_ChIP-Seq_EP156T_Human	1.14941769
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.14848570
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.13864982
60	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.13090726
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.12380029
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10784542
63	NFYA_21822215_ChIP-Seq_K562_Human	1.10047943
64	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.09935880
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.08593565
66	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.08461340
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08084870
68	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.07186386
69	ZNF263_19887448_ChIP-Seq_K562_Human	1.06386309
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05430250
71	P300_19829295_ChIP-Seq_ESCs_Human	1.05171369
72	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.05039812
73	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04691099
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04360226
75	NFYB_21822215_ChIP-Seq_K562_Human	1.04320308
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03983091
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02186841
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.01380000
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01300707
80	ER_23166858_ChIP-Seq_MCF-7_Human	0.99797859
81	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99015865
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98610594
83	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98442581
84	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.98333224
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96473044
86	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96250821
87	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96250821
88	AR_20517297_ChIP-Seq_VCAP_Human	0.95936118
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95717023
90	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94543090
91	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.93870013
92	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.92325819
93	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.91945714
94	GBX2_23144817_ChIP-Seq_PC3_Human	0.91391578
95	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.90596336
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.88929314
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88807625
98	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.88785274
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87926562
100	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.87321470

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	4.61596245
2	MP0003950_abnormal_plasma_membrane	4.27685216
3	MP0009379_abnormal_foot_pigmentation	3.50963397
4	MP0010234_abnormal_vibrissa_follicle	3.46137388
5	MP0005646_abnormal_pituitary_gland	3.09117473
6	MP0009780_abnormal_chondrocyte_physiolo	2.95419558
7	MP0002277_abnormal_respiratory_mucosa	2.91786455
8	MP0004043_abnormal_pH_regulation	2.86277225
9	MP0002653_abnormal_ependyma_morphology	2.69654610
10	MP0008789_abnormal_olfactory_epithelium	2.66692801
11	MP0005248_abnormal_Harderian_gland	2.65752503
12	MP0000516_abnormal_urinary_system	2.40858331
13	MP0005367_renal/urinary_system_phenotyp	2.40858331
14	MP0002909_abnormal_adrenal_gland	2.33635878
15	MP0002282_abnormal_trachea_morphology	2.33417364
16	MP0001346_abnormal_lacrimal_gland	2.32708075
17	MP0002132_abnormal_respiratory_system	2.22390925
18	MP0003122_maternal_imprinting	2.00470756
19	MP0006054_spinal_hemorrhage	1.87732260
20	MP0005670_abnormal_white_adipose	1.85080204
21	MP0002139_abnormal_hepatobiliary_system	1.76133890
22	MP0005220_abnormal_exocrine_pancreas	1.72394780
23	MP0005083_abnormal_biliary_tract	1.71984910
24	MP0002876_abnormal_thyroid_physiology	1.68224508
25	MP0000566_synostosis	1.65923057
26	MP0004133_heterotaxia	1.63372071
27	MP0001485_abnormal_pinna_reflex	1.63098298
28	MP0001984_abnormal_olfaction	1.61446441
29	MP0000613_abnormal_salivary_gland	1.58083384
30	MP0010030_abnormal_orbit_morphology	1.52962259
31	MP0001765_abnormal_ion_homeostasis	1.42354132
32	MP0005636_abnormal_mineral_homeostasis	1.37135710
33	MP0002233_abnormal_nose_morphology	1.34888135
34	MP0010678_abnormal_skin_adnexa	1.34881803
35	MP0001324_abnormal_eye_pigmentation	1.31007052
36	MP0004510_myositis	1.29605323
37	MP0005332_abnormal_amino_acid	1.29456982
38	MP0003938_abnormal_ear_development	1.28642134
39	MP0003878_abnormal_ear_physiology	1.28091491
40	MP0005377_hearing/vestibular/ear_phenot	1.28091491
41	MP0000631_abnormal_neuroendocrine_gland	1.26140222
42	MP0004019_abnormal_vitamin_homeostasis	1.25897504
43	MP0005623_abnormal_meninges_morphology	1.25740857
44	MP0003121_genomic_imprinting	1.23742446
45	MP0005499_abnormal_olfactory_system	1.23525490
46	MP0005394_taste/olfaction_phenotype	1.23525490
47	MP0002163_abnormal_gland_morphology	1.19884756
48	MP0001756_abnormal_urination	1.18966211
49	MP0005551_abnormal_eye_electrophysiolog	1.17659076
50	MP0002234_abnormal_pharynx_morphology	1.14523151
51	MP0009643_abnormal_urine_homeostasis	1.13496185
52	MP0009046_muscle_twitch	1.12489413
53	MP0005085_abnormal_gallbladder_physiolo	1.11460906
54	MP0001188_hyperpigmentation	1.08686600
55	MP0006292_abnormal_olfactory_placode	1.07668923
56	MP0002102_abnormal_ear_morphology	1.05562075
57	MP0005645_abnormal_hypothalamus_physiol	1.01369307
58	MP0001666_abnormal_nutrient_absorption	1.00212877
59	MP0005365_abnormal_bile_salt	1.00149048
60	MP0000639_abnormal_adrenal_gland	0.98802844
61	MP0002168_other_aberrant_phenotype	0.98323538
62	MP0000678_abnormal_parathyroid_gland	0.98012611
63	MP0001286_abnormal_eye_development	0.93257321
64	MP0001881_abnormal_mammary_gland	0.88768639
65	MP0008872_abnormal_physiological_respon	0.87711138
66	MP0002136_abnormal_kidney_physiology	0.85768632
67	MP0005166_decreased_susceptibility_to	0.85332692
68	MP0009384_cardiac_valve_regurgitation	0.83844623
69	MP0003755_abnormal_palate_morphology	0.82839125
70	MP0005195_abnormal_posterior_eye	0.80876477
71	MP0003195_calcinosis	0.80304464
72	MP0005410_abnormal_fertilization	0.79720623
73	MP0004264_abnormal_extraembryonic_tissu	0.78992937
74	MP0001293_anophthalmia	0.78945381
75	MP0004782_abnormal_surfactant_physiolog	0.78122092
76	MP0009745_abnormal_behavioral_response	0.77054295
77	MP0004484_altered_response_of	0.76052275
78	MP0000465_gastrointestinal_hemorrhage	0.75634187
79	MP0004147_increased_porphyrin_level	0.75405767
80	MP0000383_abnormal_hair_follicle	0.74740502
81	MP0002928_abnormal_bile_duct	0.73498214
82	MP0005395_other_phenotype	0.73076464
83	MP0001664_abnormal_digestion	0.72873455
84	MP0003942_abnormal_urinary_system	0.72692004
85	MP0001944_abnormal_pancreas_morphology	0.72619194
86	MP0005187_abnormal_penis_morphology	0.71986669
87	MP0003252_abnormal_bile_duct	0.70881235
88	MP0006072_abnormal_retinal_apoptosis	0.70538438
89	MP0003137_abnormal_impulse_conducting	0.70469917
90	MP0002116_abnormal_craniofacial_bone	0.70348186
91	MP0002896_abnormal_bone_mineralization	0.69415553
92	MP0001970_abnormal_pain_threshold	0.68970026
93	MP0001929_abnormal_gametogenesis	0.68155412
94	MP0005165_increased_susceptibility_to	0.65017853
95	MP0003941_abnormal_skin_development	0.64798630
96	MP0005257_abnormal_intraocular_pressure	0.64152368
97	MP0002092_abnormal_eye_morphology	0.64108135
98	MP0003787_abnormal_imprinting	0.63426347
99	MP0010307_abnormal_tumor_latency	0.62965145
100	MP0000049_abnormal_middle_ear	0.62764901

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	8.89915095
2	Absent/shortened dynein arms (HP:0200106)	8.82649362
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	8.82649362
4	Abnormal respiratory epithelium morphology (HP:0012253)	8.37367984
5	Abnormal respiratory motile cilium morphology (HP:0005938)	8.37367984
6	Rhinitis (HP:0012384)	8.33693900
7	Chronic bronchitis (HP:0004469)	8.27210998
8	Abnormal ciliary motility (HP:0012262)	8.10106242
9	Bronchiectasis (HP:0002110)	6.47701023
10	Nasal polyposis (HP:0100582)	5.78250140
11	Abnormality of the nasal mucosa (HP:0000433)	4.65327254
12	Bronchitis (HP:0012387)	4.23786985
13	Pancreatic fibrosis (HP:0100732)	3.94130772
14	True hermaphroditism (HP:0010459)	3.88240281
15	Recurrent sinusitis (HP:0011108)	3.50243175
16	Infertility (HP:0000789)	3.39564129
17	Pancreatic cysts (HP:0001737)	3.34343413
18	Male infertility (HP:0003251)	3.28545323
19	Cystic liver disease (HP:0006706)	3.23345671
20	Chronic sinusitis (HP:0011109)	3.14033353
21	Pigmentary retinal degeneration (HP:0001146)	3.13473028
22	Recurrent otitis media (HP:0000403)	3.08616116
23	Nephronophthisis (HP:0000090)	3.00778481
24	Choroideremia (HP:0001139)	3.00502407
25	Hyperactive renin-angiotensin system (HP:0000841)	2.91287332
26	Tubular atrophy (HP:0000092)	2.90278007
27	Alopecia of scalp (HP:0002293)	2.45415076
28	Abnormality of the renal medulla (HP:0100957)	2.43474357
29	Abnormality of midbrain morphology (HP:0002418)	2.39484528
30	Molar tooth sign on MRI (HP:0002419)	2.39484528
31	Medial flaring of the eyebrow (HP:0010747)	2.37035794
32	Anencephaly (HP:0002323)	2.35899719
33	Sclerocornea (HP:0000647)	2.35699052
34	Tubulointerstitial nephritis (HP:0001970)	2.32243171
35	Urethral obstruction (HP:0000796)	2.30214456
36	Occipital encephalocele (HP:0002085)	2.28400661
37	Atelectasis (HP:0100750)	2.23187350
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10029908
39	Anophthalmia (HP:0000528)	2.06967032
40	Postaxial foot polydactyly (HP:0001830)	2.06181744
41	Bile duct proliferation (HP:0001408)	2.05491890
42	Abnormal biliary tract physiology (HP:0012439)	2.05491890
43	Congenital primary aphakia (HP:0007707)	2.00056166
44	Male pseudohermaphroditism (HP:0000037)	2.00027818
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	11.9684042
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.99224759
47	Decreased circulating renin level (HP:0003351)	1.97956702
48	Furrowed tongue (HP:0000221)	1.97256125
49	Gait imbalance (HP:0002141)	1.96307974
50	Congenital hepatic fibrosis (HP:0002612)	1.95096744
51	Hyperglycinemia (HP:0002154)	1.86850886
52	Nephrogenic diabetes insipidus (HP:0009806)	1.86171337
53	Chronic otitis media (HP:0000389)	1.83957941
54	Follicular hyperkeratosis (HP:0007502)	1.83897779
55	Renal salt wasting (HP:0000127)	1.83100240
56	Asplenia (HP:0001746)	1.74548049
57	Tubulointerstitial fibrosis (HP:0005576)	1.69471855
58	Abnormality of homocysteine metabolism (HP:0010919)	1.68769727
59	Homocystinuria (HP:0002156)	1.68769727
60	Palpebral edema (HP:0100540)	1.64973526
61	Stridor (HP:0010307)	1.63972919
62	Preaxial hand polydactyly (HP:0001177)	1.63380452
63	Gout (HP:0001997)	1.62984697
64	Hyperglycinuria (HP:0003108)	1.60073199
65	Tubulointerstitial abnormality (HP:0001969)	1.59257859
66	Stage 5 chronic kidney disease (HP:0003774)	1.58313627
67	Median cleft lip (HP:0000161)	1.56352375
68	Methylmalonic acidemia (HP:0002912)	1.55652734
69	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	1.50941227
70	Vertebral hypoplasia (HP:0008417)	1.50941227
71	Azoospermia (HP:0000027)	1.50799928
72	Astrocytoma (HP:0009592)	1.49706310
73	Abnormality of the astrocytes (HP:0100707)	1.49706310
74	Postaxial hand polydactyly (HP:0001162)	1.47602653
75	Hand muscle atrophy (HP:0009130)	1.47312828
76	Ependymoma (HP:0002888)	1.46861225
77	Recurrent bronchitis (HP:0002837)	1.46432976
78	Abnormality of macular pigmentation (HP:0008002)	1.46086234
79	Myokymia (HP:0002411)	1.45448943
80	Esophageal atresia (HP:0002032)	1.43098101
81	Hamartoma of the eye (HP:0010568)	1.43086764
82	Chronic hepatic failure (HP:0100626)	1.40515742
83	Abnormality of the distal phalanges of the toes (HP:0010182)	1.40289844
84	Cone-rod dystrophy (HP:0000548)	1.38509742
85	Right ventricular cardiomyopathy (HP:0011663)	1.38298037
86	Poor coordination (HP:0002370)	1.38225314
87	Abnormality of serine family amino acid metabolism (HP:0010894)	1.38016751
88	Abnormality of glycine metabolism (HP:0010895)	1.38016751
89	Adrenal hypoplasia (HP:0000835)	1.37245845
90	Tongue fasciculations (HP:0001308)	1.36991872
91	Genital tract atresia (HP:0001827)	1.36738279
92	Hip dysplasia (HP:0001385)	1.35870265
93	Vaginal atresia (HP:0000148)	1.35171634
94	Abnormality of the renal cortex (HP:0011035)	1.34010365
95	Abnormality of renin-angiotensin system (HP:0000847)	1.32989402
96	Abnormality of chloride homeostasis (HP:0011422)	1.31494073
97	Hyperaldosteronism (HP:0000859)	1.31343955
98	Abnormality of abdominal situs (HP:0011620)	1.29651142
99	Abdominal situs inversus (HP:0003363)	1.29651142
100	Parakeratosis (HP:0001036)	1.29406035

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.64084600
2	MST4	5.41996250
3	LMTK2	4.46710790
4	STK24	3.87604023
5	EPHA2	3.03527036
6	NUAK1	3.03458349
7	PRKD3	2.71456996
8	FRK	2.59177299
9	BMPR2	2.41219166
10	MAP3K2	2.20156863
11	STK39	2.11342763
12	ERBB3	1.89736761
13	TLK1	1.82532290
14	TAOK1	1.73515964
15	FER	1.70244754
16	BCR	1.68341625
17	INSRR	1.64721489
18	PRKCI	1.44214999
19	MAP3K7	1.40168860
20	PLK4	1.35492735
21	EPHA3	1.34321761
22	BMPR1B	1.32910237
23	MAPK13	1.30502751
24	DYRK3	1.25118670
25	NME1	1.24044761
26	LRRK2	1.18262315
27	OXSR1	1.17707198
28	CSNK1G1	1.15785811
29	STK10	1.11571049
30	IKBKB	1.10737108
31	MAPKAPK3	1.09160102
32	ILK	1.07826751
33	TBK1	1.07576182
34	PAK3	1.07499793
35	BCKDK	0.98133216
36	ADRBK2	0.88045034
37	ADRBK1	0.86064393
38	STK38L	0.85202935
39	RPS6KA4	0.81887701
40	GRK1	0.80405686
41	PTK2	0.79117941
42	PIK3CA	0.77559394
43	FGFR2	0.73089512
44	SMG1	0.72996793
45	IKBKE	0.70455990
46	ICK	0.70022982
47	AKT3	0.69490213
48	PRKAA1	0.67715251
49	CSNK1A1	0.64256922
50	MET	0.63507287
51	CSNK1G2	0.63342839
52	PRKG2	0.62512889
53	CSNK1G3	0.61983310
54	MKNK2	0.61769228
55	AKT2	0.61285275
56	PHKG1	0.59590003
57	PHKG2	0.59590003
58	SRPK1	0.59138063
59	MAP3K3	0.56111587
60	ERBB2	0.54602590
61	ROCK1	0.52879346
62	TNIK	0.52192718
63	MAPKAPK5	0.47603528
64	CSNK1A1L	0.47566167
65	MAP4K2	0.47317276
66	SIK1	0.46518225
67	PINK1	0.46197487
68	PTK6	0.45608956
69	MAP3K4	0.45608142
70	CAMK4	0.45018093
71	MAP2K7	0.44184687
72	MST1R	0.43167555
73	RPS6KB2	0.42533444
74	DYRK2	0.42490195
75	ABL1	0.41435450
76	PRKCG	0.40909682
77	EGFR	0.40746916
78	PTK2B	0.40149186
79	LIMK1	0.39817884
80	SIK3	0.39698573
81	DYRK1A	0.39649706
82	PLK2	0.38839501
83	PRKCE	0.36499681
84	PLK1	0.36491644
85	SGK1	0.35942704
86	MAP3K12	0.34917324
87	MARK2	0.34841602
88	PRKAA2	0.34658449
89	DDR2	0.34205658
90	TESK1	0.33052018
91	MAP3K9	0.32958822
92	DAPK1	0.29112469
93	CDK8	0.27748116
94	ROCK2	0.27442127
95	BRSK2	0.27384400
96	HIPK2	0.27296153
97	PRKCZ	0.27222432
98	PRKACA	0.27212913
99	LATS1	0.26000122
100	AURKA	0.25641048

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.53478810
2	Caffeine metabolism_Homo sapiens_hsa00232	3.14230824
3	Arginine and proline metabolism_Homo sapiens_hsa00330	2.98349908
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.88375927
5	Chemical carcinogenesis_Homo sapiens_hsa05204	2.84876736
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.70487429
7	Histidine metabolism_Homo sapiens_hsa00340	2.69795288
8	beta-Alanine metabolism_Homo sapiens_hsa00410	2.53370940
9	Tyrosine metabolism_Homo sapiens_hsa00350	2.34534958
10	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.28153495
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22296765
12	Phenylalanine metabolism_Homo sapiens_hsa00360	2.19336389
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.18822549
14	Retinol metabolism_Homo sapiens_hsa00830	2.15997705
15	Glutathione metabolism_Homo sapiens_hsa00480	2.09493711
16	Peroxisome_Homo sapiens_hsa04146	2.00298085
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.97137213
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.93567422
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89744691
20	Huntingtons disease_Homo sapiens_hsa05016	1.83025891
21	Propanoate metabolism_Homo sapiens_hsa00640	1.80943917
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.76386025
23	Sphingolipid metabolism_Homo sapiens_hsa00600	1.74570768
24	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.71555931
25	Nicotine addiction_Homo sapiens_hsa05033	1.67672591
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62049696
27	Phototransduction_Homo sapiens_hsa04744	1.61861649
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.56404831
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42210041
30	Folate biosynthesis_Homo sapiens_hsa00790	1.41741077
31	Tight junction_Homo sapiens_hsa04530	1.39952168
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.39412368
33	Fatty acid elongation_Homo sapiens_hsa00062	1.33900370
34	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.25328805
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.22152683
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.19040263
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18153857
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17017245
39	Steroid biosynthesis_Homo sapiens_hsa00100	1.10868389
40	ABC transporters_Homo sapiens_hsa02010	1.09020705
41	Protein export_Homo sapiens_hsa03060	1.07661585
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05989487
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00443348
44	Oxidative phosphorylation_Homo sapiens_hsa00190	1.00175486
45	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.00045265
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.88084512
47	Salivary secretion_Homo sapiens_hsa04970	0.87195764
48	Hepatitis C_Homo sapiens_hsa05160	0.79096957
49	Metabolic pathways_Homo sapiens_hsa01100	0.78158334
50	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76126203
51	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73771118
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73308975
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72966250
54	Salmonella infection_Homo sapiens_hsa05132	0.72111155
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.71014232
56	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.66640373
57	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.65931315
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.65876033
59	Cocaine addiction_Homo sapiens_hsa05030	0.65307618
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.62681954
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61094949
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60917909
63	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.60711062
64	Circadian rhythm_Homo sapiens_hsa04710	0.60317320
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.59965358
66	Endometrial cancer_Homo sapiens_hsa05213	0.56214015
67	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.53554782
68	Ribosome_Homo sapiens_hsa03010	0.52880120
69	Alzheimers disease_Homo sapiens_hsa05010	0.52310251
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51580153
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51502271
72	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.48889953
73	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.48851273
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.48750953
75	Proteasome_Homo sapiens_hsa03050	0.48274689
76	Morphine addiction_Homo sapiens_hsa05032	0.44045091
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43448098
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42465594
79	Complement and coagulation cascades_Homo sapiens_hsa04610	0.40741039
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38540383
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38374646
82	Fatty acid degradation_Homo sapiens_hsa00071	0.36732985
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.35390340
84	Parkinsons disease_Homo sapiens_hsa05012	0.33679533
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33644897
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33596138
87	Butanoate metabolism_Homo sapiens_hsa00650	0.29527622
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.28738003
89	Pancreatic secretion_Homo sapiens_hsa04972	0.27520619
90	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.27084099
91	Vibrio cholerae infection_Homo sapiens_hsa05110	0.25641696
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.25500262
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.24132061
94	Melanoma_Homo sapiens_hsa05218	0.23602705
95	Ras signaling pathway_Homo sapiens_hsa04014	0.23012757
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.22232278
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.21691527
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.20896337
99	Lysosome_Homo sapiens_hsa04142	0.19980134
100	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.19927455

OR7E22P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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