OR7E23P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.70890989
2seminiferous tubule development (GO:0072520)9.57989257
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.23107141
4cAMP biosynthetic process (GO:0006171)8.88088597
5detection of chemical stimulus involved in sensory perception (GO:0050907)8.46724841
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.39944942
7enteric nervous system development (GO:0048484)7.88921141
8regulation of protein sumoylation (GO:0033233)7.57227760
9synaptic transmission, dopaminergic (GO:0001963)7.06030232
10positive regulation of mitochondrial fission (GO:0090141)7.00975675
11dendritic spine morphogenesis (GO:0060997)7.00349164
12righting reflex (GO:0060013)6.95481528
13heterotypic cell-cell adhesion (GO:0034113)6.55552284
14positive regulation of T-helper 1 type immune response (GO:0002827)6.33483432
15detection of chemical stimulus (GO:0009593)6.09156042
16icosanoid secretion (GO:0032309)6.04716742
17arachidonic acid secretion (GO:0050482)6.04716742
18hepatocyte apoptotic process (GO:0097284)6.04670466
19endothelial cell differentiation (GO:0045446)5.96044174
20positive regulation of T-helper cell differentiation (GO:0045624)5.83831075
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.46996268
22drug transmembrane transport (GO:0006855)5.26461871
23regulation of mitochondrial fission (GO:0090140)5.15667190
24phosphatidylserine acyl-chain remodeling (GO:0036150)5.10633522
25neuronal ion channel clustering (GO:0045161)5.01881077
26fatty acid derivative transport (GO:1901571)5.01149885
27icosanoid transport (GO:0071715)5.01149885
28phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.00447776
29negative regulation of alpha-beta T cell activation (GO:0046636)4.87720256
30chemosensory behavior (GO:0007635)4.78543956
31hyaluronan catabolic process (GO:0030214)4.76932571
32neural tube formation (GO:0001841)4.73699034
33regulation of T-helper 1 type immune response (GO:0002825)4.56652625
34embryonic digestive tract morphogenesis (GO:0048557)4.48750490
35cilium or flagellum-dependent cell motility (GO:0001539)4.48216964
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.45269966
37cyclic purine nucleotide metabolic process (GO:0052652)4.43771417
38nephron tubule morphogenesis (GO:0072078)4.38310151
39nephron epithelium morphogenesis (GO:0072088)4.38310151
40vocalization behavior (GO:0071625)4.34158940
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.33246543
42ATP hydrolysis coupled proton transport (GO:0015991)4.33246543
43retina layer formation (GO:0010842)4.30037921
44cyclic nucleotide biosynthetic process (GO:0009190)4.29073752
45positive regulation of membrane potential (GO:0045838)4.26543897
46attachment of spindle microtubules to kinetochore (GO:0008608)4.26420378
47regulation of T-helper cell differentiation (GO:0045622)4.24777411
48cellular response to glucagon stimulus (GO:0071377)4.23467260
49regulation of type 2 immune response (GO:0002828)4.20455047
50response to dietary excess (GO:0002021)4.20105137
51regulation of cAMP-mediated signaling (GO:0043949)4.19311446
52negative regulation of actin filament bundle assembly (GO:0032232)4.18996745
53water transport (GO:0006833)4.10644317
54mitochondrial fusion (GO:0008053)4.05665427
55dendritic spine organization (GO:0097061)4.00836565
56cAMP metabolic process (GO:0046058)3.99526948
57protein localization to synapse (GO:0035418)3.95049321
58positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.92070318
59cytoskeletal anchoring at plasma membrane (GO:0007016)3.89947388
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.82209781
61cellular zinc ion homeostasis (GO:0006882)3.77669227
62negative regulation of T cell differentiation (GO:0045581)3.70781375
63monoamine transport (GO:0015844)3.70749393
64fluid transport (GO:0042044)3.66900591
65drug transport (GO:0015893)3.60177149
66phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.60053170
67leukotriene biosynthetic process (GO:0019370)3.58620742
68positive regulation of protein targeting to membrane (GO:0090314)3.57287364
69pre-miRNA processing (GO:0031054)3.53411999
70cellular response to ATP (GO:0071318)3.50648004
71sulfur amino acid catabolic process (GO:0000098)3.49375326
72sequestering of metal ion (GO:0051238)3.48642142
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.43024423
74positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.36548669
75positive regulation of alpha-beta T cell differentiation (GO:0046638)3.35898631
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.34974191
77left/right axis specification (GO:0070986)3.30804930
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.21722018
79response to glucagon (GO:0033762)3.16463959
80renal tubule morphogenesis (GO:0061333)3.15333689
81neuromuscular process controlling posture (GO:0050884)3.15203293
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12915257
83phosphatidylcholine acyl-chain remodeling (GO:0036151)3.12099934
84neurofilament cytoskeleton organization (GO:0060052)3.10984738
85prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.10967767
86negative regulation of astrocyte differentiation (GO:0048712)3.10437691
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08700132
88adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.06452397
89adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.05433413
90positive regulation of steroid hormone secretion (GO:2000833)3.04191085
91tooth mineralization (GO:0034505)14.3965450
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6442252
93positive regulation of protein sumoylation (GO:0033235)12.0203580
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.4772721
95negative regulation of T-helper cell differentiation (GO:0045623)11.4772721
96protein K11-linked deubiquitination (GO:0035871)10.6479782
97regulation of T-helper 1 cell differentiation (GO:0045625)10.3504585
98regulation of T-helper 2 cell differentiation (GO:0045628)10.2089511
99negative regulation of type 2 immune response (GO:0002829)10.1653009
100activation of protein kinase A activity (GO:0034199)10.1418097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.59816653
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.73186617
3IGF1R_20145208_ChIP-Seq_DFB_Human4.77275818
4AR_21572438_ChIP-Seq_LNCaP_Human4.75213621
5VDR_22108803_ChIP-Seq_LS180_Human4.18888679
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.54345716
7TP53_16413492_ChIP-PET_HCT116_Human2.16737566
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03058338
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7659260
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.93887561
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89361402
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87484412
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86101298
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86101298
15GATA1_19941826_ChIP-Seq_K562_Human1.81744966
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67336052
17DROSHA_22980978_ChIP-Seq_HELA_Human1.60972985
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58553955
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56920156
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.56159219
21EGR1_19032775_ChIP-ChIP_M12_Human1.55999152
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.50246659
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.48324600
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.45694051
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43125240
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42178857
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36823236
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36694978
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32041862
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31563364
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.31441834
32RNF2_27304074_Chip-Seq_NSC_Mouse1.24470191
33RXR_22108803_ChIP-Seq_LS180_Human1.24378858
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.22612545
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22478309
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18817498
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17933557
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15650966
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12075983
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.11679309
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11320557
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10567824
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10135596
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.07388273
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.06034732
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05787328
47SOX2_18555785_Chip-Seq_ESCs_Mouse1.03703582
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03412724
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02964769
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.02159770
51ER_23166858_ChIP-Seq_MCF-7_Human1.01511857
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00555188
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00214490
54GBX2_23144817_ChIP-Seq_PC3_Human1.00159261
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00087349
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.99628444
57ARNT_22903824_ChIP-Seq_MCF-7_Human0.98939511
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98683293
59EZH2_22144423_ChIP-Seq_EOC_Human0.97886028
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97721153
61PRDM14_20953172_ChIP-Seq_ESCs_Human0.97288730
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96987931
63SMAD4_21741376_ChIP-Seq_HESCs_Human0.95890447
64TBL1_22424771_ChIP-Seq_293T_Human0.95404060
65CMYC_18555785_Chip-Seq_ESCs_Mouse0.95079750
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94528514
67BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94150759
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93398004
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91714270
70CJUN_26792858_Chip-Seq_BT549_Human0.90628453
71GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90313923
72PHF8_20622853_ChIP-Seq_HELA_Human0.90104274
73STAT3_23295773_ChIP-Seq_U87_Human0.88801015
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88525643
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87470027
76NANOG_16518401_ChIP-PET_MESCs_Mouse0.87469825
77CTCF_27219007_Chip-Seq_Bcells_Human0.86190057
78BCAT_22108803_ChIP-Seq_LS180_Human0.85273623
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84602272
80SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84560619
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83605351
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82987312
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81801758
84EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81504967
85RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81504967
86KLF4_18555785_Chip-Seq_ESCs_Mouse0.81165370
87NMYC_18555785_Chip-Seq_ESCs_Mouse0.81119351
88E2F1_18555785_Chip-Seq_ESCs_Mouse0.80907668
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80602609
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80135209
91REST_21632747_ChIP-Seq_MESCs_Mouse0.78040196
92GATA2_19941826_ChIP-Seq_K562_Human0.77699136
93RING1B_27294783_Chip-Seq_ESCs_Mouse0.76024657
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.75866060
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.75744063
96ISL1_27105846_Chip-Seq_CPCs_Mouse0.74925745
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74741449
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74452029
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74452029
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74452029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.75939929
2MP0004130_abnormal_muscle_cell5.01245528
3MP0004264_abnormal_extraembryonic_tissu4.03281770
4MP0003252_abnormal_bile_duct3.62444024
5MP0004133_heterotaxia2.83291532
6MP0002928_abnormal_bile_duct2.72913683
7MP0006072_abnormal_retinal_apoptosis2.43341638
8MP0005448_abnormal_energy_balance2.30947243
9MP0005408_hypopigmentation2.25289302
10MP0002751_abnormal_autonomic_nervous2.23169604
11MP0003329_amyloid_beta_deposits2.17360855
12MP0004272_abnormal_basement_membrane2.14678442
13MP0001270_distended_abdomen2.13156513
14MP0005084_abnormal_gallbladder_morpholo12.7026612
15MP0003943_abnormal_hepatobiliary_system1.76670846
16MP0005220_abnormal_exocrine_pancreas1.66656333
17MP0005379_endocrine/exocrine_gland_phen1.60768375
18MP0005165_increased_susceptibility_to1.59390615
19MP0009764_decreased_sensitivity_to1.45284293
20MP0001958_emphysema1.43774207
21MP0000604_amyloidosis1.39716372
22MP0001529_abnormal_vocalization1.31257969
23MP0003718_maternal_effect1.23417186
24MP0005646_abnormal_pituitary_gland1.08089175
25MP0000465_gastrointestinal_hemorrhage1.03937684
26MP0002909_abnormal_adrenal_gland1.01515688
27MP0000470_abnormal_stomach_morphology1.01370618
28MP0001905_abnormal_dopamine_level0.99434967
29MP0001944_abnormal_pancreas_morphology0.99256840
30MP0002572_abnormal_emotion/affect_behav0.95820868
31MP0008569_lethality_at_weaning0.93693428
32MP0003638_abnormal_response/metabolism_0.90432902
33MP0001915_intracranial_hemorrhage0.82080250
34MP0005164_abnormal_response_to0.80948423
35MP0008469_abnormal_protein_level0.79907206
36MP0000371_diluted_coat_color0.79423028
37MP0003121_genomic_imprinting0.79414085
38MP0001800_abnormal_humoral_immune0.77031805
39MP0002405_respiratory_system_inflammati0.75822995
40MP0004019_abnormal_vitamin_homeostasis0.74555897
41MP0000609_abnormal_liver_physiology0.72341321
42MP0002693_abnormal_pancreas_physiology0.71772409
43MP0003866_abnormal_defecation0.71602750
44MP0002098_abnormal_vibrissa_morphology0.69064632
45MP0000703_abnormal_thymus_morphology0.66564827
46MP0008875_abnormal_xenobiotic_pharmacok0.66332135
47MP0001851_eye_inflammation0.64429061
48MP0005253_abnormal_eye_physiology0.63794113
49MP0005387_immune_system_phenotype0.63750345
50MP0001790_abnormal_immune_system0.63750345
51MP0004947_skin_inflammation0.63273983
52MP0002136_abnormal_kidney_physiology0.62975485
53MP0001533_abnormal_skeleton_physiology0.62803363
54MP0002078_abnormal_glucose_homeostasis0.62798448
55MP0003953_abnormal_hormone_level0.60682563
56MP0002998_abnormal_bone_remodeling0.58158346
57MP0001845_abnormal_inflammatory_respons0.51035104
58MP0002722_abnormal_immune_system0.46882583
59MP0009642_abnormal_blood_homeostasis0.46874287
60MP0002419_abnormal_innate_immunity0.39981624
61MP0005334_abnormal_fat_pad0.39462302
62MP0003195_calcinosis0.39279069
63MP0002822_catalepsy0.38569338
64MP0000759_abnormal_skeletal_muscle0.38234289
65MP0002429_abnormal_blood_cell0.38086780
66MP0000920_abnormal_myelination0.37816677
67MP0005551_abnormal_eye_electrophysiolog0.37228531
68MP0000477_abnormal_intestine_morphology0.36956317
69MP0000598_abnormal_liver_morphology0.36476602
70MP0002452_abnormal_antigen_presenting0.35484315
71MP0005365_abnormal_bile_salt0.35389480
72MP0009931_abnormal_skin_appearance0.35368367
73MP0004484_altered_response_of0.35314188
74MP0001299_abnormal_eye_distance/0.33932032
75MP0002882_abnormal_neuron_morphology0.32860619
76MP0005423_abnormal_somatic_nervous0.32442763
77MP0005390_skeleton_phenotype0.32307418
78MP0008004_abnormal_stomach_pH0.32213981
79MP0001986_abnormal_taste_sensitivity0.32060526
80MP0002420_abnormal_adaptive_immunity0.32005546
81MP0000716_abnormal_immune_system0.31743508
82MP0001819_abnormal_immune_cell0.31390310
83MP0001501_abnormal_sleep_pattern0.30802782
84MP0001835_abnormal_antigen_presentation0.30490912
85MP0002398_abnormal_bone_marrow0.30116822
86MP0002229_neurodegeneration0.29746641
87MP0002723_abnormal_immune_serum0.28620887
88MP0005395_other_phenotype0.28042085
89MP0001175_abnormal_lung_morphology0.27995889
90MP0005000_abnormal_immune_tolerance0.26675672
91MP0002735_abnormal_chemical_nociception0.26039164
92MP0000689_abnormal_spleen_morphology0.24542468
93MP0009053_abnormal_anal_canal0.23183021
94MP0002396_abnormal_hematopoietic_system0.22799372
95MP0002066_abnormal_motor_capabilities/c0.22578224
96MP0002128_abnormal_blood_circulation0.21948923
97MP0003634_abnormal_glial_cell0.20545924
98MP0000249_abnormal_blood_vessel0.20204738
99MP0005391_vision/eye_phenotype0.19894413
100MP0002113_abnormal_skeleton_development0.19756788

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of dental color (HP:0011073)8.31140176
2Abnormality of renal resorption (HP:0011038)8.14225170
3Osteomalacia (HP:0002749)7.93700715
4Polyuria (HP:0000103)7.61421741
5Abnormality of the dental pulp (HP:0006479)7.60730049
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.81357043
7Abnormal urine output (HP:0012590)6.52039711
8Abnormality of renal excretion (HP:0011036)5.69085264
9Round ear (HP:0100830)5.51605954
10Chronic bronchitis (HP:0004469)4.94762421
11Volvulus (HP:0002580)4.33365157
12IgM deficiency (HP:0002850)4.27181969
13Lip pit (HP:0100267)4.23990240
14Autoimmune thrombocytopenia (HP:0001973)4.06398201
15Toxemia of pregnancy (HP:0100603)4.01223692
16Nephrocalcinosis (HP:0000121)3.91261078
17Esophageal varix (HP:0002040)3.88247761
18Abnormality of midbrain morphology (HP:0002418)3.79426369
19Molar tooth sign on MRI (HP:0002419)3.79426369
20Lipoatrophy (HP:0100578)3.44734150
21Sparse lateral eyebrow (HP:0005338)3.39625719
22Depressed nasal tip (HP:0000437)3.36371042
23Large earlobe (HP:0009748)3.32903807
24Abnormal respiratory motile cilium physiology (HP:0012261)3.27480567
25Rhinitis (HP:0012384)3.26243372
26Tachypnea (HP:0002789)3.24106306
27Drooling (HP:0002307)3.19378958
28Hypoparathyroidism (HP:0000829)3.16118943
29Intestinal fistula (HP:0100819)3.10828196
30Excessive salivation (HP:0003781)3.06776566
31Panhypogammaglobulinemia (HP:0003139)3.04514635
32Personality changes (HP:0000751)2.89661423
33Hyperphosphaturia (HP:0003109)2.89101920
34Thick eyebrow (HP:0000574)2.87578602
35Petechiae (HP:0000967)2.69769762
36Nephronophthisis (HP:0000090)2.61819763
37Hepatitis (HP:0012115)2.57975636
38Ureteral stenosis (HP:0000071)2.57658250
39Dilated cardiomyopathy (HP:0001644)2.56876624
40Abnormality of the fingertips (HP:0001211)2.49198134
41Short 5th finger (HP:0009237)2.44577560
42Abnormal urine phosphate concentration (HP:0012599)2.44350524
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.40193428
44Chronic mucocutaneous candidiasis (HP:0002728)2.38162535
45Recurrent cutaneous fungal infections (HP:0011370)2.38162535
46Ureteral obstruction (HP:0006000)2.37759778
47Gingival overgrowth (HP:0000212)2.33528927
48Striae distensae (HP:0001065)2.33463455
49Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.33061104
50Glycosuria (HP:0003076)2.32333404
51Abnormality of urine glucose concentration (HP:0011016)2.32333404
52Abnormality of transition element cation homeostasis (HP:0011030)2.32264946
53Sudden cardiac death (HP:0001645)2.31346992
54Colitis (HP:0002583)2.29592382
55Nephropathy (HP:0000112)2.25108805
56Hypercalciuria (HP:0002150)2.23429405
57Periauricular skin pits (HP:0100277)2.15892054
58Preauricular pit (HP:0004467)2.15892054
59Bronchitis (HP:0012387)2.12539963
60Inability to walk (HP:0002540)2.12045363
61Recurrent otitis media (HP:0000403)2.11236194
62Decreased muscle mass (HP:0003199)2.10590167
63Agammaglobulinemia (HP:0004432)2.10476312
64Anal stenosis (HP:0002025)2.04120133
65Abnormality of salivation (HP:0100755)2.03150168
66Delayed eruption of teeth (HP:0000684)2.00887593
67Chondrocalcinosis (HP:0000934)2.00431988
68Overgrowth (HP:0001548)12.3762187
69Amelogenesis imperfecta (HP:0000705)11.7411471
70Abnormality of calcium-phosphate metabolism (HP:0100530)10.1573921
71Abnormality of Sharpey fibers (HP:0100685)1.95625564
72Abnormality of the renal medulla (HP:0100957)1.94793772
73Chorioretinal coloboma (HP:0000567)1.88064415
74Ectopic kidney (HP:0000086)1.87275206
75Truncal ataxia (HP:0002078)1.84600277
76Preauricular skin tag (HP:0000384)1.84362463
77Prominent supraorbital ridges (HP:0000336)1.80259109
78Renal tubular dysfunction (HP:0000124)1.79716105
79Stage 5 chronic kidney disease (HP:0003774)1.76012830
80Limited elbow extension (HP:0001377)1.75671349
81Villous atrophy (HP:0011473)1.69681090
82Abnormality of small intestinal villus morphology (HP:0011472)1.69681090
83Torticollis (HP:0000473)1.63741880
84Palmoplantar keratoderma (HP:0000982)1.58428596
85Small hand (HP:0200055)1.58422488
86Ectropion (HP:0000656)1.58208529
87Oculomotor apraxia (HP:0000657)1.57728911
88Skin tags (HP:0010609)1.55414452
89Polyneuropathy (HP:0001271)1.55299613
90Blepharitis (HP:0000498)1.53826384
91Prenatal maternal abnormality (HP:0002686)1.50469918
92Bronchiectasis (HP:0002110)1.49128550
93Viral hepatitis (HP:0006562)1.48713456
94Skin pits (HP:0100276)1.46614742
95Mask-like facies (HP:0000298)1.44909178
96Inflammation of the large intestine (HP:0002037)1.42442400
97Proximal placement of thumb (HP:0009623)1.41253469
98Osteoarthritis (HP:0002758)1.40340828
99Highly arched eyebrow (HP:0002553)1.40149114
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.29959948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.67990189
2BLK4.36659918
3STK34.12036891
4RIPK43.24627978
5CDC42BPA2.19734553
6BMPR22.12799530
7NTRK214.2404887
8HIPK21.24989570
9FGFR10.93802956
10ROCK20.80753400
11SYK0.67380908
12SRC0.64077787
13OBSCN0.59496853
14PRKCQ0.59014120
15INSRR0.58304276
16PRKAA10.57781056
17ROCK10.55556230
18MUSK0.54926996
19MAP4K20.48168795
20GRK70.45949852
21PRKACG0.43956613
22ABL10.42379634
23TXK0.41370286
24WNK30.41268801
25TIE10.40833566
26MAPK150.40354752
27GRK10.39535060
28SRPK10.35831224
29ADRBK20.35826032
30PRKACA0.35810560
31PRKACB0.35632931
32CAMK2A0.31442115
33ERBB40.31388394
34PIK3CG0.29402792
35LYN0.25357632
36PLK10.25329924
37EPHA40.23773360
38MATK0.23440728
39MAPK140.22615517
40MST1R0.22287135
41PRKCA0.22165100
42GSK3B0.21740256
43TTN0.21671436
44LMTK20.20976307
45PLK40.20134749
46PRKCB0.20084356
47RPS6KA30.19852526
48DDR20.18987968
49PHKG20.18071117
50PHKG10.18071117
51KIT0.17868774
52FYN0.17768200
53KDR0.17003873
54TEC0.16644355
55GRK50.16395477
56EPHA20.16281783
57TLK10.15057917
58ITK0.14902646
59CDK10.14360474
60CSNK1A10.14034542
61PIM20.13968051
62PRKCD0.13440258
63CHUK0.12895631
64GRK60.12086837
65WNK40.11063474
66OXSR10.10602270
67MAP2K60.10434951
68PRKDC0.10421297
69MAPK90.10378108
70BTK0.09406005
71TNK20.09373704
72LCK0.09140064
73HCK0.08702726
74PKN10.08098365
75IGF1R0.07496004
76ADRBK10.07477835
77PRKCG0.07168873
78TAOK20.07008989
79EGFR0.06980530
80CAMK2G0.06306253
81AKT10.06238621
82ABL20.05868581
83TGFBR20.05591921
84PIM10.05386557
85PRKG20.05128875
86NTRK10.04085614
87IKBKE0.03852351
88INSR0.03794514
89PIK3CA0.03616259
90STK390.03387420
91PRKCE0.03048039
92MOS0.02943355
93MYLK0.02444027
94PRKG10.02256189
95MAPK40.02120372
96MAP2K70.01972004
97ZAK0.01928561
98CAMK2B0.01607810
99SGK10.01383201
100PINK10.01342410

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.26249143
2Sulfur relay system_Homo sapiens_hsa041223.75478990
3Sulfur metabolism_Homo sapiens_hsa009203.70144295
4Ovarian steroidogenesis_Homo sapiens_hsa049133.35394626
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.14612186
6Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.90081874
7Linoleic acid metabolism_Homo sapiens_hsa005912.87774816
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.75537759
9Collecting duct acid secretion_Homo sapiens_hsa049662.51660513
10Vibrio cholerae infection_Homo sapiens_hsa051102.41596525
11Bile secretion_Homo sapiens_hsa049762.38688809
12Thyroid hormone synthesis_Homo sapiens_hsa049182.24009496
13Pancreatic secretion_Homo sapiens_hsa049722.21663099
14Salivary secretion_Homo sapiens_hsa049702.13797059
15Fat digestion and absorption_Homo sapiens_hsa049752.11200594
16Gastric acid secretion_Homo sapiens_hsa049712.10832064
17Synaptic vesicle cycle_Homo sapiens_hsa047212.05708992
18Cocaine addiction_Homo sapiens_hsa050301.94182540
19Circadian entrainment_Homo sapiens_hsa047131.84899189
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83593679
21Insulin secretion_Homo sapiens_hsa049111.79689826
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.75367386
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74600243
24Glutamatergic synapse_Homo sapiens_hsa047241.72215247
25Taste transduction_Homo sapiens_hsa047421.69928357
26GABAergic synapse_Homo sapiens_hsa047271.68162437
27Dilated cardiomyopathy_Homo sapiens_hsa054141.67483119
28Morphine addiction_Homo sapiens_hsa050321.66906381
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.64857431
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59519018
31Ether lipid metabolism_Homo sapiens_hsa005651.59299437
32Gap junction_Homo sapiens_hsa045401.56377549
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44272727
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43930261
35Amphetamine addiction_Homo sapiens_hsa050311.40582229
36GnRH signaling pathway_Homo sapiens_hsa049121.39604286
37Melanogenesis_Homo sapiens_hsa049161.34893318
38Arachidonic acid metabolism_Homo sapiens_hsa005901.28561286
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28515231
40Oxytocin signaling pathway_Homo sapiens_hsa049211.17222657
41Platelet activation_Homo sapiens_hsa046111.16866901
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14676830
43Cholinergic synapse_Homo sapiens_hsa047251.14071550
44Estrogen signaling pathway_Homo sapiens_hsa049151.08782291
45Calcium signaling pathway_Homo sapiens_hsa040201.05275741
46Circadian rhythm_Homo sapiens_hsa047100.99096867
47Dorso-ventral axis formation_Homo sapiens_hsa043200.87757562
48Pyruvate metabolism_Homo sapiens_hsa006200.82749102
49Serotonergic synapse_Homo sapiens_hsa047260.75598410
50Oocyte meiosis_Homo sapiens_hsa041140.74416953
51ECM-receptor interaction_Homo sapiens_hsa045120.73905387
52Chemokine signaling pathway_Homo sapiens_hsa040620.72622742
53Rheumatoid arthritis_Homo sapiens_hsa053230.68474520
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64806165
55RNA degradation_Homo sapiens_hsa030180.54006898
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47771889
57cAMP signaling pathway_Homo sapiens_hsa040240.45897236
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.42779912
59Alcoholism_Homo sapiens_hsa050340.39974813
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39117010
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34788527
62Primary immunodeficiency_Homo sapiens_hsa053400.34545401
63Dopaminergic synapse_Homo sapiens_hsa047280.34015936
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.33004379
65Staphylococcus aureus infection_Homo sapiens_hsa051500.32605756
66Prion diseases_Homo sapiens_hsa050200.30956579
67Parkinsons disease_Homo sapiens_hsa050120.30775536
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.29086374
69Rap1 signaling pathway_Homo sapiens_hsa040150.24059615
70Purine metabolism_Homo sapiens_hsa002300.23003998
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.22312277
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.19816548
73Retinol metabolism_Homo sapiens_hsa008300.18881388
74Hedgehog signaling pathway_Homo sapiens_hsa043400.18040461
75Glucagon signaling pathway_Homo sapiens_hsa049220.15419157
76Phagosome_Homo sapiens_hsa041450.15278980
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15060471
78Tuberculosis_Homo sapiens_hsa051520.14464030
79Oxidative phosphorylation_Homo sapiens_hsa001900.13630268
80Systemic lupus erythematosus_Homo sapiens_hsa053220.13548225
81Ras signaling pathway_Homo sapiens_hsa040140.11813402
82HTLV-I infection_Homo sapiens_hsa051660.11364311
83Type I diabetes mellitus_Homo sapiens_hsa049400.11139550
84Caffeine metabolism_Homo sapiens_hsa002320.09692308
85African trypanosomiasis_Homo sapiens_hsa051430.09642944
86Leishmaniasis_Homo sapiens_hsa051400.09306747
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08263893
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.06727711
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.06593014
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05811664
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05550692
92Renin secretion_Homo sapiens_hsa049240.04603378
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.04128215
94Hematopoietic cell lineage_Homo sapiens_hsa046400.03877384
95Chemical carcinogenesis_Homo sapiens_hsa052040.03187593
96Amoebiasis_Homo sapiens_hsa051460.01806792
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00691416
98Asthma_Homo sapiens_hsa053100.00558029
99Nicotine addiction_Homo sapiens_hsa050330.00052219
100Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0314645

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