OR7E24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)9.39859448
2regulation of T-helper 2 cell differentiation (GO:0045628)9.35297375
3negative regulation of type 2 immune response (GO:0002829)9.31111026
4activation of protein kinase A activity (GO:0034199)9.26503349
5seminiferous tubule development (GO:0072520)8.96021561
6negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.73573480
7positive regulation of RNA splicing (GO:0033120)8.69065319
8cAMP biosynthetic process (GO:0006171)8.51066176
9negative regulation of alpha-beta T cell differentiation (GO:0046639)7.88871664
10* detection of chemical stimulus involved in sensory perception (GO:0050907)7.33418515
11synaptic transmission, dopaminergic (GO:0001963)7.30918954
12enteric nervous system development (GO:0048484)7.24431941
13positive regulation of mitochondrial fission (GO:0090141)6.99991183
14regulation of protein sumoylation (GO:0033233)6.98963847
15righting reflex (GO:0060013)6.51705599
16dendritic spine morphogenesis (GO:0060997)6.33861000
17heterotypic cell-cell adhesion (GO:0034113)6.06207839
18positive regulation of T-helper 1 type immune response (GO:0002827)5.98625741
19arachidonic acid secretion (GO:0050482)5.66699258
20icosanoid secretion (GO:0032309)5.66699258
21drug transmembrane transport (GO:0006855)5.62307537
22phosphatidylinositol acyl-chain remodeling (GO:0036149)5.55777623
23positive regulation of T-helper cell differentiation (GO:0045624)5.40046519
24endothelial cell differentiation (GO:0045446)5.26850470
25* detection of chemical stimulus (GO:0009593)5.25864626
26hepatocyte apoptotic process (GO:0097284)5.16284043
27regulation of mitochondrial fission (GO:0090140)5.13916556
28attachment of spindle microtubules to kinetochore (GO:0008608)5.13589306
29chemosensory behavior (GO:0007635)5.09451218
30phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.95622665
31phosphatidylserine acyl-chain remodeling (GO:0036150)4.94691831
32cilium or flagellum-dependent cell motility (GO:0001539)4.81488547
33icosanoid transport (GO:0071715)4.64659779
34fatty acid derivative transport (GO:1901571)4.64659779
35negative regulation of alpha-beta T cell activation (GO:0046636)4.55553079
36neuronal ion channel clustering (GO:0045161)4.55313323
37cyclic purine nucleotide metabolic process (GO:0052652)4.44176224
38neural tube formation (GO:0001841)4.42152125
39hyaluronan catabolic process (GO:0030214)4.35671054
40cyclic nucleotide biosynthetic process (GO:0009190)4.28167055
41negative regulation of actin filament bundle assembly (GO:0032232)4.27629727
42regulation of T-helper 1 type immune response (GO:0002825)4.22996043
43vocalization behavior (GO:0071625)4.21613785
44embryonic digestive tract morphogenesis (GO:0048557)4.20004518
45retina layer formation (GO:0010842)4.14106075
46positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.05490103
47regulation of T-helper cell differentiation (GO:0045622)4.05152293
48cAMP metabolic process (GO:0046058)4.03199633
49regulation of cAMP-mediated signaling (GO:0043949)4.02215828
50water transport (GO:0006833)3.95879957
51protein localization to synapse (GO:0035418)3.90862464
52positive regulation of membrane potential (GO:0045838)3.89329492
53cellular response to glucagon stimulus (GO:0071377)3.88967357
54nephron tubule morphogenesis (GO:0072078)3.86098627
55nephron epithelium morphogenesis (GO:0072088)3.86098627
56response to dietary excess (GO:0002021)3.84285221
57regulation of female receptivity (GO:0045924)3.82254385
58dendritic spine organization (GO:0097061)3.78940733
59energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.77172864
60ATP hydrolysis coupled proton transport (GO:0015991)3.77172864
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.77089796
62drug transport (GO:0015893)3.76183485
63regulation of type 2 immune response (GO:0002828)3.69893817
64left/right axis specification (GO:0070986)3.69435274
65negative regulation of T cell differentiation (GO:0045581)3.67322985
66monoamine transport (GO:0015844)3.58109853
67positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.57735084
68male meiosis (GO:0007140)3.55608723
69fluid transport (GO:0042044)3.53626506
70phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.52690605
71negative regulation of homotypic cell-cell adhesion (GO:0034111)3.50110906
72cytoskeletal anchoring at plasma membrane (GO:0007016)3.46573906
73single fertilization (GO:0007338)3.43919822
74positive regulation of steroid hormone secretion (GO:2000833)3.41650066
75positive regulation of protein targeting to membrane (GO:0090314)3.39811349
76mitochondrial fusion (GO:0008053)3.36350502
77leukotriene biosynthetic process (GO:0019370)3.35976074
78DNA methylation involved in gamete generation (GO:0043046)3.34361884
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33218061
80neuromuscular process controlling posture (GO:0050884)3.31127934
81female mating behavior (GO:0060180)3.29455844
82adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.27896373
83cellular zinc ion homeostasis (GO:0006882)3.27682530
84cellular response to ATP (GO:0071318)3.27419552
85negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.21665193
86negative regulation of astrocyte differentiation (GO:0048712)3.20249927
87regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.14473127
88mitochondrial fission (GO:0000266)3.12701984
89positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.12611987
90sulfur amino acid catabolic process (GO:0000098)3.04867153
91regulation of corticosteroid hormone secretion (GO:2000846)3.04180186
92phosphatidylcholine acyl-chain remodeling (GO:0036151)3.03665291
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01558923
94regulation of hydrogen peroxide-induced cell death (GO:1903205)2.99633968
95tooth mineralization (GO:0034505)13.0646778
96* detection of chemical stimulus involved in sensory perception of smell (GO:0050911)11.3505712
97positive regulation of protein sumoylation (GO:0033235)11.2171083
98negative regulation of T-helper cell differentiation (GO:0045623)10.8799251
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)10.8799251
100protein K11-linked deubiquitination (GO:0035871)10.2958377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.24971578
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.94269857
3IGF1R_20145208_ChIP-Seq_DFB_Human4.58968869
4AR_21572438_ChIP-Seq_LNCaP_Human4.34557386
5EZH2_22144423_ChIP-Seq_EOC_Human4.07882469
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.07005370
7VDR_22108803_ChIP-Seq_LS180_Human3.95537969
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.73639215
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.10433515
10POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.05340577
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05340577
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04441689
13TP53_16413492_ChIP-PET_HCT116_Human2.01147334
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87376197
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81746307
16GBX2_23144817_ChIP-Seq_PC3_Human1.72795592
17DROSHA_22980978_ChIP-Seq_HELA_Human1.71682560
18YY1_22570637_ChIP-Seq_MALME-3M_Human1.65401997
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65239866
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64078608
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62436263
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59648282
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47530727
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46911800
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46911800
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46911800
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.45273671
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44046297
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.43837249
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42879940
31SMAD3_21741376_ChIP-Seq_HESCs_Human1.39067359
32RXR_22108803_ChIP-Seq_LS180_Human1.34674155
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34415949
34PRDM14_20953172_ChIP-Seq_ESCs_Human1.33173245
35ER_23166858_ChIP-Seq_MCF-7_Human1.32783950
36GATA1_19941826_ChIP-Seq_K562_Human1.32724841
37TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.32669827
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27346341
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.25533230
40RNF2_27304074_Chip-Seq_NSC_Mouse1.24378859
41STAT3_23295773_ChIP-Seq_U87_Human1.20864025
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20413413
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.20316516
44TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18750697
45* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18506097
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16494555
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13691744
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13361555
49TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12915090
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12675787
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12028171
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.11597112
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10357629
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.10171412
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05687398
56CBP_20019798_ChIP-Seq_JUKART_Human1.05687398
57SMAD4_21741376_ChIP-Seq_HESCs_Human1.05097400
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04335243
59SMAD4_21799915_ChIP-Seq_A2780_Human1.04172281
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02766629
61CJUN_26792858_Chip-Seq_BT549_Human1.02241817
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01580951
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00736870
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00478063
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.00236463
66SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99676005
67SMAD4_21741376_ChIP-Seq_EPCs_Human0.99355910
68HNFA_21074721_ChIP-Seq_CACO-2_Human0.98889864
69CBX2_27304074_Chip-Seq_ESCs_Mouse0.97823111
70TCF4_22108803_ChIP-Seq_LS180_Human0.97631730
71BCAT_22108803_ChIP-Seq_LS180_Human0.97036877
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96979262
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96454376
74TBL1_22424771_ChIP-Seq_293T_Human0.96001678
75NANOG_20526341_ChIP-Seq_ESCs_Human0.95275438
76REST_21632747_ChIP-Seq_MESCs_Mouse0.95088255
77EGR1_19032775_ChIP-ChIP_M12_Human0.94773772
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94598001
79MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94225765
80SOX2_18555785_Chip-Seq_ESCs_Mouse0.94219943
81EED_16625203_ChIP-ChIP_MESCs_Mouse0.93054157
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92898278
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92368546
84HTT_18923047_ChIP-ChIP_STHdh_Human0.92008460
85AR_25329375_ChIP-Seq_VCAP_Human0.91837959
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.91094798
87PHF8_20622853_ChIP-Seq_HELA_Human0.90108845
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.86784965
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85560108
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85353761
91SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84950822
92CMYC_18555785_Chip-Seq_ESCs_Mouse0.84251106
93E2F1_18555785_Chip-Seq_ESCs_Mouse0.83223279
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83102796
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79660121
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79626036
97EP300_21415370_ChIP-Seq_HL-1_Mouse0.79348239
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.79286689
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79154074
100P300_19829295_ChIP-Seq_ESCs_Human0.78863905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism8.83357084
2MP0004130_abnormal_muscle_cell4.69710685
3MP0003252_abnormal_bile_duct3.81596909
4MP0003718_maternal_effect3.52414826
5MP0004264_abnormal_extraembryonic_tissu3.23898174
6MP0006072_abnormal_retinal_apoptosis2.74274601
7MP0002928_abnormal_bile_duct2.69905379
8MP0004133_heterotaxia2.39120196
9MP0005408_hypopigmentation2.21680726
10MP0005379_endocrine/exocrine_gland_phen2.12997106
11MP0002751_abnormal_autonomic_nervous2.12059999
12MP0003136_yellow_coat_color2.06027068
13MP0005084_abnormal_gallbladder_morpholo11.4990615
14MP0003329_amyloid_beta_deposits1.92674462
15MP0005448_abnormal_energy_balance1.79801077
16MP0001270_distended_abdomen1.76477632
17MP0005646_abnormal_pituitary_gland1.65970824
18MP0003943_abnormal_hepatobiliary_system1.53003907
19MP0003879_abnormal_hair_cell1.47141123
20MP0004272_abnormal_basement_membrane1.45148795
21MP0009780_abnormal_chondrocyte_physiolo1.29149531
22MP0005395_other_phenotype1.28996981
23MP0002909_abnormal_adrenal_gland1.24414438
24MP0005220_abnormal_exocrine_pancreas1.21738626
25MP0005165_increased_susceptibility_to1.15045578
26MP0005360_urolithiasis1.14536961
27MP0000372_irregular_coat_pigmentation1.11376989
28MP0005410_abnormal_fertilization1.10579153
29MP0001905_abnormal_dopamine_level1.10355688
30MP0000604_amyloidosis1.10298611
31MP0002163_abnormal_gland_morphology1.06529921
32MP0002572_abnormal_emotion/affect_behav1.05847355
33MP0006276_abnormal_autonomic_nervous1.05043436
34MP0009764_decreased_sensitivity_to1.00890346
35MP0000470_abnormal_stomach_morphology0.98477592
36MP0004381_abnormal_hair_follicle0.96548937
37MP0005551_abnormal_eye_electrophysiolog0.95323774
38MP0002138_abnormal_hepatobiliary_system0.92142339
39MP0001944_abnormal_pancreas_morphology0.89787039
40MP0003638_abnormal_response/metabolism_0.89406909
41MP0008789_abnormal_olfactory_epithelium0.87081459
42MP0001958_emphysema0.86271971
43MP0005253_abnormal_eye_physiology0.85943513
44MP0002132_abnormal_respiratory_system0.83582200
45MP0001529_abnormal_vocalization0.81975208
46MP0003121_genomic_imprinting0.78549611
47MP0008875_abnormal_xenobiotic_pharmacok0.77686738
48MP0008569_lethality_at_weaning0.74940311
49MP0002098_abnormal_vibrissa_morphology0.74686915
50MP0003866_abnormal_defecation0.73411493
51MP0008877_abnormal_DNA_methylation0.73346193
52MP0006292_abnormal_olfactory_placode0.72687318
53MP0002693_abnormal_pancreas_physiology0.70773741
54MP0000371_diluted_coat_color0.68758617
55MP0002136_abnormal_kidney_physiology0.67039321
56MP0002234_abnormal_pharynx_morphology0.66674455
57MP0001851_eye_inflammation0.66580052
58MP0004019_abnormal_vitamin_homeostasis0.66577636
59MP0008469_abnormal_protein_level0.66014202
60MP0002210_abnormal_sex_determination0.65621258
61MP0001501_abnormal_sleep_pattern0.65272812
62MP0002139_abnormal_hepatobiliary_system0.65233179
63MP0001986_abnormal_taste_sensitivity0.64759772
64MP0002161_abnormal_fertility/fecundity0.63673241
65MP0001929_abnormal_gametogenesis0.60493653
66MP0001800_abnormal_humoral_immune0.59782499
67MP0000465_gastrointestinal_hemorrhage0.59247781
68MP0003699_abnormal_female_reproductive0.59125818
69MP0002998_abnormal_bone_remodeling0.58833356
70MP0003953_abnormal_hormone_level0.58201080
71MP0002405_respiratory_system_inflammati0.57490189
72MP0010368_abnormal_lymphatic_system0.57330348
73MP0010030_abnormal_orbit_morphology0.56826029
74MP0000703_abnormal_thymus_morphology0.56530003
75MP0000609_abnormal_liver_physiology0.56365469
76MP0005387_immune_system_phenotype0.56214127
77MP0001790_abnormal_immune_system0.56214127
78MP0005164_abnormal_response_to0.55695274
79MP0003195_calcinosis0.55166759
80MP0003698_abnormal_male_reproductive0.51842648
81MP0002229_neurodegeneration0.50573935
82MP0000631_abnormal_neuroendocrine_gland0.48704210
83MP0004947_skin_inflammation0.47808843
84MP0002078_abnormal_glucose_homeostasis0.47113829
85MP0002735_abnormal_chemical_nociception0.46911771
86MP0000653_abnormal_sex_gland0.45931946
87MP0005499_abnormal_olfactory_system0.45724104
88MP0005394_taste/olfaction_phenotype0.45724104
89MP0005187_abnormal_penis_morphology0.43117813
90MP0005334_abnormal_fat_pad0.42442360
91MP0004885_abnormal_endolymph0.40675602
92MP0005503_abnormal_tendon_morphology0.39956579
93MP0001293_anophthalmia0.39408172
94MP0001984_abnormal_olfaction0.37170314
95MP0002722_abnormal_immune_system0.36851692
96MP0009642_abnormal_blood_homeostasis0.36764025
97MP0001915_intracranial_hemorrhage0.36582660
98MP0005647_abnormal_sex_gland0.35605270
99MP0001533_abnormal_skeleton_physiology0.34606301
100MP0003880_abnormal_central_pattern0.32720420

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)9.85860001
2Abnormality of calcium-phosphate metabolism (HP:0100530)9.05478762
3Osteomalacia (HP:0002749)8.11308161
4Abnormality of dental color (HP:0011073)7.27411492
5Abnormality of the dental pulp (HP:0006479)7.06850508
6Abnormality of renal resorption (HP:0011038)6.83997478
7Polyuria (HP:0000103)6.77786479
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.11194083
9Abnormal urine output (HP:0012590)5.78461436
10Lip pit (HP:0100267)5.62450385
11Abnormality of renal excretion (HP:0011036)5.04242987
12Molar tooth sign on MRI (HP:0002419)4.55378277
13Abnormality of midbrain morphology (HP:0002418)4.55378277
14Round ear (HP:0100830)4.47064859
15Chronic bronchitis (HP:0004469)4.47056288
16Volvulus (HP:0002580)4.01138511
17Toxemia of pregnancy (HP:0100603)3.70353050
18Nephrocalcinosis (HP:0000121)3.47659686
19Abnormal respiratory motile cilium physiology (HP:0012261)3.43385427
20Autoimmune thrombocytopenia (HP:0001973)3.40716676
21IgM deficiency (HP:0002850)3.39232940
22Rhinitis (HP:0012384)3.34042655
23Tachypnea (HP:0002789)3.32124991
24Esophageal varix (HP:0002040)3.25695639
25Nephronophthisis (HP:0000090)3.13559041
26Depressed nasal tip (HP:0000437)2.88920554
27Sparse lateral eyebrow (HP:0005338)2.75640830
28Hypoparathyroidism (HP:0000829)2.68725389
29Panhypogammaglobulinemia (HP:0003139)2.63272569
30Lipoatrophy (HP:0100578)2.59249973
31Ectopic kidney (HP:0000086)2.58699613
32Intestinal fistula (HP:0100819)2.46204419
33Hypoplasia of the fovea (HP:0007750)2.42709289
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.42709289
35Abnormality of the renal medulla (HP:0100957)2.40282736
36Hyperphosphaturia (HP:0003109)2.37300129
37Drooling (HP:0002307)2.36872615
38Periauricular skin pits (HP:0100277)2.35798407
39Preauricular pit (HP:0004467)2.35798407
40Congenital stationary night blindness (HP:0007642)2.35781607
41Thick eyebrow (HP:0000574)2.30871224
42Abnormal urine phosphate concentration (HP:0012599)2.27939251
43Personality changes (HP:0000751)2.27759507
44Hepatitis (HP:0012115)2.27430192
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.26879662
46Striae distensae (HP:0001065)2.26666359
47Excessive salivation (HP:0003781)2.23885982
48Inability to walk (HP:0002540)2.21061579
49Supernumerary spleens (HP:0009799)2.19112591
50Ureteral obstruction (HP:0006000)2.17973285
51Severe visual impairment (HP:0001141)2.14395752
52Prominent supraorbital ridges (HP:0000336)2.14025180
53Ureteral stenosis (HP:0000071)2.12775611
54Recurrent cutaneous fungal infections (HP:0011370)2.09860621
55Chronic mucocutaneous candidiasis (HP:0002728)2.09860621
56Abnormality of transition element cation homeostasis (HP:0011030)2.09845777
57Abnormality of urine glucose concentration (HP:0011016)2.05995421
58Glycosuria (HP:0003076)2.05995421
59Nephropathy (HP:0000112)2.02126732
60Dilated cardiomyopathy (HP:0001644)2.01979089
61Abnormality of the fovea (HP:0000493)2.00948399
62Overgrowth (HP:0001548)10.0956866
63Skin pits (HP:0100276)1.99323383
64Large earlobe (HP:0009748)1.97551029
65Hypercalciuria (HP:0002150)1.93286427
66Chorioretinal coloboma (HP:0000567)1.90430287
67Sudden cardiac death (HP:0001645)1.88737478
68Petechiae (HP:0000967)1.87369871
69Concave nail (HP:0001598)1.85748575
70Bronchitis (HP:0012387)1.83991477
71Abnormal rod and cone electroretinograms (HP:0008323)1.82997332
72Truncal ataxia (HP:0002078)1.82388361
73Short 5th finger (HP:0009237)1.77855765
74Abnormality of Sharpey fibers (HP:0100685)1.77791063
75Oculomotor apraxia (HP:0000657)1.77069813
76Abnormality of the renal collecting system (HP:0004742)1.75710236
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72293418
78Colitis (HP:0002583)1.71189129
79Torticollis (HP:0000473)1.71182211
80Aplasia/Hypoplasia of the macula (HP:0008059)1.68301386
81Gingival overgrowth (HP:0000212)1.68276768
82Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.67478712
83Duplicated collecting system (HP:0000081)1.65870511
84Renal tubular dysfunction (HP:0000124)1.65554048
85Agammaglobulinemia (HP:0004432)1.65283752
86Delayed eruption of teeth (HP:0000684)1.64104571
87Highly arched eyebrow (HP:0002553)1.63463763
88Bile duct proliferation (HP:0001408)1.62333893
89Abnormal biliary tract physiology (HP:0012439)1.62333893
90Recurrent otitis media (HP:0000403)1.61395408
91Blepharitis (HP:0000498)1.60933008
92Truncal obesity (HP:0001956)1.59720722
93Stage 5 chronic kidney disease (HP:0003774)1.58371173
94Aplasia/Hypoplasia affecting the retina (HP:0008061)1.58366436
95Bronchiectasis (HP:0002110)1.55273190
96Villous atrophy (HP:0011473)1.54272118
97Abnormality of small intestinal villus morphology (HP:0011472)1.54272118
98Azoospermia (HP:0000027)1.52674775
99Chondrocalcinosis (HP:0000934)1.48494690
100Preauricular skin tag (HP:0000384)1.47515670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.10944719
2STK34.20152837
3BLK3.58184252
4RIPK42.42717571
5TXK2.17699679
6NTRK213.3459176
7BMPR21.89092903
8CDC42BPA1.79700903
9FRK1.40345480
10GRK11.32210912
11MOS1.28483737
12ADRBK21.23483627
13GRK71.04964308
14HIPK20.92103709
15FGFR10.86998984
16ARAF0.77395443
17MAP3K90.76141422
18ROCK20.75820392
19KIT0.73444237
20SYK0.73332768
21PRKCQ0.71948616
22TIE10.64983040
23MAP3K130.64136805
24TAOK30.62850514
25PLK10.60035480
26INSRR0.59827634
27ROCK10.59681219
28BUB10.58321778
29TGFBR20.57640226
30OBSCN0.55807351
31CDK120.54382742
32PRKACG0.53653156
33MUSK0.53509860
34PRKACB0.52472205
35SRC0.51977480
36TNIK0.51181877
37PINK10.49474521
38CAMK2A0.49207373
39STK100.48030345
40PRKACA0.47727211
41KDR0.45990799
42NTRK30.45611539
43AURKA0.45193266
44GRK50.44328043
45ACVR1B0.44172457
46STK240.41867346
47PRKAA10.40198954
48BMPR1B0.40009018
49STK390.39316813
50WNK30.37591378
51SRPK10.37121735
52NEK60.36636446
53ITK0.36285809
54MAP4K20.35402102
55TNK20.34815103
56WNK40.34257167
57PIK3CG0.33285549
58ADRBK10.32958915
59MST40.32800879
60ABL10.30692876
61GSK3B0.29187088
62PLK40.28836639
63LYN0.28555945
64PRKCA0.27868584
65MAP2K70.27598066
66ZAK0.27595739
67PRKCI0.27247178
68MAP3K40.27029708
69CHUK0.25733869
70ERBB40.24881709
71MAPK140.24687576
72MET0.24554899
73MAPK150.24375513
74CDK10.23694891
75DAPK20.22575221
76IGF1R0.21789956
77PIM10.21607748
78TTK0.20935324
79PRKG10.20353180
80PKN10.20091172
81RPS6KA30.19965065
82CSNK1A10.19930151
83EGFR0.19915139
84PRKCE0.19702774
85LMTK20.19554674
86PRKCB0.18618080
87EPHA20.17695738
88MATK0.17254796
89CDK70.16222056
90OXSR10.16140313
91TLK10.14858645
92BRAF0.14289851
93CDK20.14263796
94CDK90.14259729
95LCK0.14028573
96IKBKE0.13688213
97FYN0.12920052
98EPHA40.12919442
99DDR20.12907478
100PLK20.12534822

Predicted pathways (KEGG)

RankGene SetZ-score
1* Olfactory transduction_Homo sapiens_hsa047404.24688602
2Ovarian steroidogenesis_Homo sapiens_hsa049133.62992692
3Sulfur relay system_Homo sapiens_hsa041223.34262542
4Sulfur metabolism_Homo sapiens_hsa009203.29547708
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.22989713
6Linoleic acid metabolism_Homo sapiens_hsa005913.05355346
7Bile secretion_Homo sapiens_hsa049762.48505031
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.48147550
9Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.43531301
10Collecting duct acid secretion_Homo sapiens_hsa049662.40436349
11Salivary secretion_Homo sapiens_hsa049702.35327106
12Circadian entrainment_Homo sapiens_hsa047132.10799374
13Pancreatic secretion_Homo sapiens_hsa049722.10106057
14Gastric acid secretion_Homo sapiens_hsa049712.00990643
15Vibrio cholerae infection_Homo sapiens_hsa051101.98756467
16Fat digestion and absorption_Homo sapiens_hsa049751.98617756
17Morphine addiction_Homo sapiens_hsa050321.98527155
18GABAergic synapse_Homo sapiens_hsa047271.97002121
19Taste transduction_Homo sapiens_hsa047421.96720180
20Thyroid hormone synthesis_Homo sapiens_hsa049181.96195049
21Cocaine addiction_Homo sapiens_hsa050301.92094615
22Synaptic vesicle cycle_Homo sapiens_hsa047211.88912486
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.87506661
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79902780
25Glutamatergic synapse_Homo sapiens_hsa047241.79512078
26Insulin secretion_Homo sapiens_hsa049111.78701826
27Gap junction_Homo sapiens_hsa045401.68091556
28Ether lipid metabolism_Homo sapiens_hsa005651.61688047
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60723333
30Dilated cardiomyopathy_Homo sapiens_hsa054141.55896293
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45779410
32Dorso-ventral axis formation_Homo sapiens_hsa043201.44538784
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43185845
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.39719409
35Amphetamine addiction_Homo sapiens_hsa050311.38829306
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37175296
37Circadian rhythm_Homo sapiens_hsa047101.35781774
38Oocyte meiosis_Homo sapiens_hsa041141.35090163
39Arachidonic acid metabolism_Homo sapiens_hsa005901.32624473
40Calcium signaling pathway_Homo sapiens_hsa040201.26307540
41Oxytocin signaling pathway_Homo sapiens_hsa049211.25935318
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25267087
43GnRH signaling pathway_Homo sapiens_hsa049121.20334455
44Cholinergic synapse_Homo sapiens_hsa047251.16080697
45Platelet activation_Homo sapiens_hsa046111.15403445
46Melanogenesis_Homo sapiens_hsa049161.14301988
47RNA degradation_Homo sapiens_hsa030181.12640687
48Serotonergic synapse_Homo sapiens_hsa047260.98028682
49Caffeine metabolism_Homo sapiens_hsa002320.95540809
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91159557
51Estrogen signaling pathway_Homo sapiens_hsa049150.83017991
52Chemokine signaling pathway_Homo sapiens_hsa040620.75683531
53Phototransduction_Homo sapiens_hsa047440.71282737
54ECM-receptor interaction_Homo sapiens_hsa045120.65922462
55cAMP signaling pathway_Homo sapiens_hsa040240.61604472
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60697086
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59452665
58Rheumatoid arthritis_Homo sapiens_hsa053230.58939248
59Pyruvate metabolism_Homo sapiens_hsa006200.57743896
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.57074323
61Nicotine addiction_Homo sapiens_hsa050330.56100836
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53159956
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.47274793
64Primary immunodeficiency_Homo sapiens_hsa053400.43627079
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41387468
66Dopaminergic synapse_Homo sapiens_hsa047280.41125317
67Alcoholism_Homo sapiens_hsa050340.38817312
68Purine metabolism_Homo sapiens_hsa002300.38284788
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.35275807
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33548028
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32701538
72Retinol metabolism_Homo sapiens_hsa008300.32122976
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31724730
74Renin secretion_Homo sapiens_hsa049240.30967999
75ABC transporters_Homo sapiens_hsa020100.30638460
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.30576004
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30002385
78Chemical carcinogenesis_Homo sapiens_hsa052040.29760410
79Prion diseases_Homo sapiens_hsa050200.20854894
80Rap1 signaling pathway_Homo sapiens_hsa040150.18469264
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17831729
82Basal transcription factors_Homo sapiens_hsa030220.13520290
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13375675
84Ras signaling pathway_Homo sapiens_hsa040140.13342183
85Antigen processing and presentation_Homo sapiens_hsa046120.13322084
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.12906360
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.12020075
88Staphylococcus aureus infection_Homo sapiens_hsa051500.10750805
89HTLV-I infection_Homo sapiens_hsa051660.09421848
90Hedgehog signaling pathway_Homo sapiens_hsa043400.08023097
91Type I diabetes mellitus_Homo sapiens_hsa049400.06068458
92Phagosome_Homo sapiens_hsa041450.05904731
93Tryptophan metabolism_Homo sapiens_hsa003800.05569515
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05536544
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.03122700
96Hematopoietic cell lineage_Homo sapiens_hsa046400.01968630
97African trypanosomiasis_Homo sapiens_hsa051430.01683609
98Graft-versus-host disease_Homo sapiens_hsa053320.01585920
99Parkinsons disease_Homo sapiens_hsa050120.01275174
100Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0071937

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