OR7E26P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid nucleus differentiation (GO:0007289)6.73303015
2germ cell migration (GO:0008354)6.54312135
3sperm motility (GO:0030317)6.41830608
4DNA deamination (GO:0045006)6.41329601
5positive regulation of meiosis (GO:0045836)6.23395166
6positive regulation of male gonad development (GO:2000020)6.23218544
7negative regulation of meiosis (GO:0045835)6.06207256
8microtubule severing (GO:0051013)5.95722465
9single strand break repair (GO:0000012)5.81933514
10positive regulation of meiotic cell cycle (GO:0051446)5.79138105
11axonemal dynein complex assembly (GO:0070286)5.55480827
12cilium or flagellum-dependent cell motility (GO:0001539)5.47873374
13acrosome reaction (GO:0007340)5.28804538
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.28651875
15cytidine metabolic process (GO:0046087)5.06995997
16cytidine catabolic process (GO:0006216)5.06995997
17cytidine deamination (GO:0009972)5.06995997
18piRNA metabolic process (GO:0034587)4.97346523
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.92170523
20pyrimidine ribonucleoside catabolic process (GO:0046133)4.81585311
21fusion of sperm to egg plasma membrane (GO:0007342)4.77682145
22male sex determination (GO:0030238)4.77511834
23neural tube formation (GO:0001841)4.76109337
24oocyte development (GO:0048599)4.74666740
25regulation of male gonad development (GO:2000018)4.72584283
26potassium ion export (GO:0071435)4.71847950
27membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.62089124
28microtubule depolymerization (GO:0007019)4.41329676
29rRNA methylation (GO:0031167)4.37939660
30epithelial cilium movement (GO:0003351)4.29931062
31positive regulation of catecholamine secretion (GO:0033605)4.28072803
32Sertoli cell development (GO:0060009)4.21508993
33protein polyglutamylation (GO:0018095)4.18641020
34signal peptide processing (GO:0006465)4.16781260
35acrosome assembly (GO:0001675)4.12938511
36rRNA modification (GO:0000154)4.06024764
37membrane repolarization during action potential (GO:0086011)3.99891145
38multicellular organism reproduction (GO:0032504)3.97746841
39spermatid development (GO:0007286)3.92974982
40cilium movement (GO:0003341)3.91058078
41sex differentiation (GO:0007548)3.87338472
42sperm capacitation (GO:0048240)3.80281579
43positive regulation of interleukin-8 secretion (GO:2000484)3.77420436
44sympathetic nervous system development (GO:0048485)3.71182050
45sperm-egg recognition (GO:0035036)3.69110690
46regulation of double-strand break repair via homologous recombination (GO:0010569)3.68920671
47negative regulation of meiotic cell cycle (GO:0051447)3.61626484
48microtubule polymerization or depolymerization (GO:0031109)3.58016890
49RNA destabilization (GO:0050779)3.49498169
50plasma membrane fusion (GO:0045026)3.48130761
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.47673836
52ovulation cycle (GO:0042698)3.46340144
53response to redox state (GO:0051775)3.46179998
54resolution of meiotic recombination intermediates (GO:0000712)3.42859799
55axoneme assembly (GO:0035082)3.40533746
56negative regulation of transcription regulatory region DNA binding (GO:2000678)3.35410387
57male meiosis I (GO:0007141)3.35165279
58cornea development in camera-type eye (GO:0061303)3.34957227
59regulation of cilium movement (GO:0003352)3.34315435
60DNA methylation involved in gamete generation (GO:0043046)3.31510036
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21187463
62somatic hypermutation of immunoglobulin genes (GO:0016446)3.21187463
63spermatogenesis (GO:0007283)3.20782650
64male gamete generation (GO:0048232)3.19343807
65chaperone-mediated protein complex assembly (GO:0051131)3.14659146
66neuronal stem cell maintenance (GO:0097150)3.12897626
67reproduction (GO:0000003)3.08967456
68regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.04073719
69cilium organization (GO:0044782)3.03384742
70tongue development (GO:0043586)3.03011786
71fatty acid elongation (GO:0030497)3.02865723
72cell-cell recognition (GO:0009988)3.02655119
73dicarboxylic acid catabolic process (GO:0043649)3.02473610
74behavioral response to nicotine (GO:0035095)2.99579996
75platelet dense granule organization (GO:0060155)2.98805500
76cilium assembly (GO:0042384)2.97440129
77somite development (GO:0061053)2.95396125
78chromosome condensation (GO:0030261)2.93108640
79gamete generation (GO:0007276)2.92795685
80regulation of timing of cell differentiation (GO:0048505)2.92552645
81establishment of protein localization to Golgi (GO:0072600)2.92426091
82germ cell development (GO:0007281)2.89803770
83membrane repolarization (GO:0086009)2.88518347
84DNA packaging (GO:0006323)2.86516658
85positive regulation of potassium ion transmembrane transport (GO:1901381)2.86374345
86binding of sperm to zona pellucida (GO:0007339)2.83394291
87cardiac left ventricle morphogenesis (GO:0003214)2.83390087
88regulation of sensory perception of pain (GO:0051930)2.82516263
89regulation of sensory perception (GO:0051931)2.82516263
90olfactory bulb development (GO:0021772)2.81614072
91oogenesis (GO:0048477)2.81549377
92negative regulation of inclusion body assembly (GO:0090084)2.81087295
93meiosis I (GO:0007127)2.80645485
94protein targeting to Golgi (GO:0000042)2.80179003
95magnesium ion transport (GO:0015693)2.78469774
96response to nitrosative stress (GO:0051409)2.75578257
97calcium ion-dependent exocytosis (GO:0017156)2.72564112
98positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72121113
99centriole replication (GO:0007099)2.69927662
100regulation of meiosis I (GO:0060631)10.2062687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.78322979
2ZNF274_21170338_ChIP-Seq_K562_Hela3.68524748
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21202974
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.08803267
5IGF1R_20145208_ChIP-Seq_DFB_Human2.86009106
6TAF15_26573619_Chip-Seq_HEK293_Human2.85321077
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62954487
8ER_23166858_ChIP-Seq_MCF-7_Human2.47439455
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33152580
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32797565
11EZH2_22144423_ChIP-Seq_EOC_Human2.28666604
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27674643
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.19371094
14P300_19829295_ChIP-Seq_ESCs_Human2.17104177
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.10428380
16EWS_26573619_Chip-Seq_HEK293_Human1.99681366
17CBP_20019798_ChIP-Seq_JUKART_Human1.99315466
18IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.99315466
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95668267
20ETV2_25802403_ChIP-Seq_MESCs_Mouse1.83487082
21FUS_26573619_Chip-Seq_HEK293_Human1.82310321
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79438096
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78084179
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.77088560
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74604486
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74604486
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70552341
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69803398
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65568699
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.63991027
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61890444
32IRF1_19129219_ChIP-ChIP_H3396_Human1.61206239
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.59944287
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58810116
35FOXA1_21572438_ChIP-Seq_LNCaP_Human1.58211491
36VDR_22108803_ChIP-Seq_LS180_Human1.56923615
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54232264
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.54232264
39NANOG_19829295_ChIP-Seq_ESCs_Human1.48977069
40SOX2_19829295_ChIP-Seq_ESCs_Human1.48977069
41RNF2_27304074_Chip-Seq_NSC_Mouse1.47600941
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46965769
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.44471307
44FOXH1_21741376_ChIP-Seq_EPCs_Human1.43098260
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.43031536
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42207808
47STAT3_23295773_ChIP-Seq_U87_Human1.40922554
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.39105167
49SMAD4_21799915_ChIP-Seq_A2780_Human1.37699345
50ERG_20517297_ChIP-Seq_VCAP_Human1.37142569
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.35708735
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.35549245
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35017463
54TCF4_23295773_ChIP-Seq_U87_Human1.34099261
55RUNX2_22187159_ChIP-Seq_PCA_Human1.33575651
56AR_25329375_ChIP-Seq_VCAP_Human1.32194057
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31707475
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29881313
59TAF2_19829295_ChIP-Seq_ESCs_Human1.27193084
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25969644
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25744032
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24708139
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24506573
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24157006
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23984865
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.23959623
67GBX2_23144817_ChIP-Seq_PC3_Human1.22772620
68AR_20517297_ChIP-Seq_VCAP_Human1.22606500
69SMAD3_21741376_ChIP-Seq_ESCs_Human1.21843177
70AR_21572438_ChIP-Seq_LNCaP_Human1.21341857
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21162238
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20387632
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20112634
74EGR1_19032775_ChIP-ChIP_M12_Human1.19731326
75TP53_22573176_ChIP-Seq_HFKS_Human1.18264675
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.14718655
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.14269391
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12893840
79SMRT_27268052_Chip-Seq_Bcells_Human1.10949900
80NANOG_20526341_ChIP-Seq_ESCs_Human1.09478742
81MYC_19829295_ChIP-Seq_ESCs_Human1.07321158
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.03170733
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02553791
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02532216
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02160983
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01222285
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00246956
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00227032
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.99202240
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.99136749
91VDR_23849224_ChIP-Seq_CD4+_Human0.95884567
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95675021
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95038995
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93222068
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.93210487
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92031629
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.91662115
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89642804
99RBPJ_21746931_ChIP-Seq_IB4_Human0.87773855
100OCT4_20526341_ChIP-Seq_ESCs_Human0.87022598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology6.44667118
2MP0005377_hearing/vestibular/ear_phenot6.44667118
3MP0005410_abnormal_fertilization4.31861722
4MP0001485_abnormal_pinna_reflex3.02070494
5MP0003880_abnormal_central_pattern2.99710698
6MP0002234_abnormal_pharynx_morphology2.74273888
7MP0002653_abnormal_ependyma_morphology2.71341577
8MP0009379_abnormal_foot_pigmentation2.65580758
9MP0000569_abnormal_digit_pigmentation2.28776408
10MP0001929_abnormal_gametogenesis2.25785277
11MP0000383_abnormal_hair_follicle2.23525769
12MP0005423_abnormal_somatic_nervous2.19879967
13MP0003698_abnormal_male_reproductive2.13324702
14MP0005670_abnormal_white_adipose2.08844155
15MP0006072_abnormal_retinal_apoptosis2.08717887
16MP0005551_abnormal_eye_electrophysiolog1.96957717
17MP0001501_abnormal_sleep_pattern1.93240892
18MP0001486_abnormal_startle_reflex1.88854635
19MP0005253_abnormal_eye_physiology1.87088248
20MP0002210_abnormal_sex_determination1.79072031
21MP0004215_abnormal_myocardial_fiber1.74801663
22MP0002102_abnormal_ear_morphology1.68318734
23MP0003693_abnormal_embryo_hatching1.66668913
24MP0002160_abnormal_reproductive_system1.65162339
25MP0003646_muscle_fatigue1.57803200
26MP0001293_anophthalmia1.57546670
27MP0009053_abnormal_anal_canal1.50633439
28MP0004145_abnormal_muscle_electrophysio1.47368440
29MP0002751_abnormal_autonomic_nervous1.44293091
30MP0008877_abnormal_DNA_methylation1.43208743
31MP0001919_abnormal_reproductive_system1.42822939
32MP0004742_abnormal_vestibular_system1.39810689
33MP0005174_abnormal_tail_pigmentation1.37547432
34MP0005645_abnormal_hypothalamus_physiol1.36964663
35MP0001145_abnormal_male_reproductive1.35852807
36MP0002095_abnormal_skin_pigmentation1.34841260
37MP0001963_abnormal_hearing_physiology1.30534994
38MP0000653_abnormal_sex_gland1.27224569
39MP0000538_abnormal_urinary_bladder1.26134650
40MP0010678_abnormal_skin_adnexa1.25541844
41MP0003137_abnormal_impulse_conducting1.24369758
42MP0003011_delayed_dark_adaptation1.22769170
43MP0006276_abnormal_autonomic_nervous1.20190283
44MP0005391_vision/eye_phenotype1.17926034
45MP0000026_abnormal_inner_ear1.15093951
46MP0009745_abnormal_behavioral_response1.13257912
47MP0009046_muscle_twitch1.12912584
48MP0005389_reproductive_system_phenotype1.09689233
49MP0001986_abnormal_taste_sensitivity1.08228546
50MP0000427_abnormal_hair_cycle1.07345623
51MP0002161_abnormal_fertility/fecundity1.06631544
52MP0003567_abnormal_fetal_cardiomyocyte1.06320870
53MP0002067_abnormal_sensory_capabilities1.06232699
54MP0003136_yellow_coat_color1.03989035
55MP0002928_abnormal_bile_duct1.03137085
56MP0000371_diluted_coat_color1.01828382
57MP0001968_abnormal_touch/_nociception0.99188138
58MP0002736_abnormal_nociception_after0.98880762
59MP0005195_abnormal_posterior_eye0.97252051
60MP0003936_abnormal_reproductive_system0.96728800
61MP0001881_abnormal_mammary_gland0.94564960
62MP0000647_abnormal_sebaceous_gland0.94518668
63MP0002254_reproductive_system_inflammat0.93270196
64MP0001905_abnormal_dopamine_level0.90562058
65MP0002229_neurodegeneration0.89197112
66MP0001765_abnormal_ion_homeostasis0.89078933
67MP0000579_abnormal_nail_morphology0.87431048
68MP0002752_abnormal_somatic_nervous0.86720778
69MP0003252_abnormal_bile_duct0.82964750
70MP0003718_maternal_effect0.82578395
71MP0003119_abnormal_digestive_system0.81567312
72MP0000013_abnormal_adipose_tissue0.76244556
73MP0010386_abnormal_urinary_bladder0.74620088
74MP0008789_abnormal_olfactory_epithelium0.74506789
75MP0002184_abnormal_innervation0.73835973
76MP0004133_heterotaxia0.72626683
77MP0001764_abnormal_homeostasis0.71516389
78MP0009384_cardiac_valve_regurgitation0.71079125
79MP0000631_abnormal_neuroendocrine_gland0.69539959
80MP0005365_abnormal_bile_salt0.67899766
81MP0006036_abnormal_mitochondrial_physio0.66863938
82MP0001286_abnormal_eye_development0.66837268
83MP0001119_abnormal_female_reproductive0.66627366
84MP0004957_abnormal_blastocyst_morpholog0.66214171
85MP0002735_abnormal_chemical_nociception0.64763838
86MP0002282_abnormal_trachea_morphology0.64657803
87MP0005636_abnormal_mineral_homeostasis0.64237376
88MP0002557_abnormal_social/conspecific_i0.64218048
89MP0006292_abnormal_olfactory_placode0.63816751
90MP0002882_abnormal_neuron_morphology0.61350856
91MP0006082_CNS_inflammation0.60629641
92MP0002064_seizures0.60301977
93MP0002638_abnormal_pupillary_reflex0.57685138
94MP0004134_abnormal_chest_morphology0.56752179
95MP0009765_abnormal_xenobiotic_induced0.54711329
96MP0001727_abnormal_embryo_implantation0.54470563
97MP0009115_abnormal_fat_cell0.53922716
98MP0002909_abnormal_adrenal_gland0.53692419
99MP0003861_abnormal_nervous_system0.53106852
100MP0002109_abnormal_limb_morphology0.51805281

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.60118603
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.60118603
3Neonatal short-limb short stature (HP:0008921)5.00728775
4Chronic hepatic failure (HP:0100626)4.42940590
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.23187759
6Nephronophthisis (HP:0000090)4.21358552
7Aplastic anemia (HP:0001915)4.08876582
8Abnormality of the corticospinal tract (HP:0002492)4.03492653
9Abnormal respiratory motile cilium physiology (HP:0012261)4.00492239
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.96022489
11Absent/shortened dynein arms (HP:0200106)3.96022489
12Abnormal ciliary motility (HP:0012262)3.58474748
13Amyotrophic lateral sclerosis (HP:0007354)3.56464000
14Abnormal respiratory epithelium morphology (HP:0012253)3.56391638
15Abnormal respiratory motile cilium morphology (HP:0005938)3.56391638
16Pancreatic cysts (HP:0001737)3.49498411
17Pancreatic fibrosis (HP:0100732)3.43889771
18Natal tooth (HP:0000695)3.43096105
19Impaired vibration sensation in the lower limbs (HP:0002166)3.42175145
20Facial cleft (HP:0002006)3.42051442
21Abnormal biliary tract physiology (HP:0012439)3.40918772
22Bile duct proliferation (HP:0001408)3.40918772
23Severe visual impairment (HP:0001141)3.37745136
24Abnormality of macular pigmentation (HP:0008002)3.35139987
25True hermaphroditism (HP:0010459)3.30960430
26Abnormality of the renal medulla (HP:0100957)3.26431317
27Postaxial foot polydactyly (HP:0001830)3.19374870
28Molar tooth sign on MRI (HP:0002419)3.11416191
29Abnormality of midbrain morphology (HP:0002418)3.11416191
30Rhinitis (HP:0012384)2.99808453
31Supernumerary spleens (HP:0009799)2.96085982
32Tubulointerstitial nephritis (HP:0001970)2.85372652
33Bony spicule pigmentary retinopathy (HP:0007737)2.83278457
34Birth length less than 3rd percentile (HP:0003561)2.78178776
35Congenital hepatic fibrosis (HP:0002612)2.74276353
36Menstrual irregularities (HP:0000858)2.72024335
37Ventricular fibrillation (HP:0001663)2.67817148
38Pendular nystagmus (HP:0012043)2.64893077
39Attenuation of retinal blood vessels (HP:0007843)2.64645628
40Tubular atrophy (HP:0000092)2.63324559
41Male pseudohermaphroditism (HP:0000037)2.62136904
42Synostosis of carpal bones (HP:0005048)2.58904323
43Chronic bronchitis (HP:0004469)2.55646041
44Occipital encephalocele (HP:0002085)2.50890771
45Abnormal rod and cone electroretinograms (HP:0008323)2.46065167
46Sclerocornea (HP:0000647)2.40307771
47Ependymoma (HP:0002888)2.40114325
48Impaired vibratory sensation (HP:0002495)2.34227583
49Agnosia (HP:0010524)2.34163114
50Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.33850722
51Anencephaly (HP:0002323)2.30630152
52Abnormality of the alveolar ridges (HP:0006477)2.29854818
53Bronchiectasis (HP:0002110)2.28137355
54Abnormality of urine glucose concentration (HP:0011016)2.28101507
55Glycosuria (HP:0003076)2.28101507
56Neoplasm of the heart (HP:0100544)2.25897916
57Morphological abnormality of the pyramidal tract (HP:0002062)2.22007290
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.16796165
59Abnormality of the renal cortex (HP:0011035)2.13009740
60Glioma (HP:0009733)2.11388451
61Abnormality of the astrocytes (HP:0100707)2.11039512
62Astrocytoma (HP:0009592)2.11039512
63Medulloblastoma (HP:0002885)2.10237688
64Osteomalacia (HP:0002749)2.05450577
65Cystic liver disease (HP:0006706)2.05073176
66Abolished electroretinogram (ERG) (HP:0000550)2.01026366
67Syncope (HP:0001279)2.00857185
68Aplasia/Hypoplasia of the uvula (HP:0010293)1.99867843
69Insidious onset (HP:0003587)1.99124689
70Termporal pattern (HP:0011008)1.99124689
71Severe Myopia (HP:0011003)1.98527085
72Insulin-resistant diabetes mellitus (HP:0000831)1.98144057
73Prolonged QT interval (HP:0001657)1.93055568
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.91453539
75Polydipsia (HP:0001959)1.89840605
76Abnormal drinking behavior (HP:0030082)1.89840605
77Neoplasm of striated muscle (HP:0009728)1.89799167
78Hyperkalemia (HP:0002153)1.86677224
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83991925
80Cubitus valgus (HP:0002967)1.83564225
81Alveolar cell carcinoma (HP:0006519)1.82373895
82Infertility (HP:0000789)1.81834865
83Chronic sinusitis (HP:0011109)1.79955666
84Glucose intolerance (HP:0000833)1.79178114
85Abnormal mitochondria in muscle tissue (HP:0008316)1.77953611
86Hemiparesis (HP:0001269)1.75846350
87Meckel diverticulum (HP:0002245)1.75635964
88Acute necrotizing encephalopathy (HP:0006965)1.74408822
89Medial flaring of the eyebrow (HP:0010747)1.74205126
90Abnormality of the ileum (HP:0001549)1.73072592
91Advanced eruption of teeth (HP:0006288)1.72427428
92Tubulointerstitial abnormality (HP:0001969)1.71826508
93Gonadotropin excess (HP:0000837)1.71723836
94Enlarged epiphyses (HP:0010580)1.69898099
95Rhabdomyosarcoma (HP:0002859)1.69224368
96Clubbing of toes (HP:0100760)1.66234258
97Postaxial hand polydactyly (HP:0001162)1.65585461
98Absent speech (HP:0001344)1.62410253
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.62075493
100Preaxial hand polydactyly (HP:0001177)1.61936228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.72454784
2PIK3CA3.82718463
3ERBB42.93581243
4PLK42.70023608
5CAMKK22.68612953
6TESK12.54228252
7ACVR1B2.52558727
8KDR2.49555663
9BCKDK2.36122073
10PINK12.35340967
11MAPK152.26297246
12CDK82.20722030
13TRIM282.14829864
14BMPR1B2.11321748
15ADRBK22.08922273
16WEE12.06020110
17CAMK1G2.05863900
18FRK1.85491477
19NUAK11.73532236
20MAPK131.60274885
21WNK31.50498503
22MAP4K21.46728741
23PLK21.46556788
24GRK11.36488453
25CAMKK11.30467120
26CDK31.29616378
27PKN11.28779030
28DYRK21.20144070
29DYRK31.20080142
30MST41.19533784
31STK38L1.19261373
32TXK1.17754189
33TYRO31.16819083
34BCR1.13683369
35VRK21.09683442
36AKT31.09396802
37DDR21.07417985
38INSRR1.04321294
39PIK3CG1.02948269
40TESK21.00884202
41PRKCQ0.99031346
42TAOK30.97334853
43WNK10.95287469
44CAMK40.95232254
45MAP3K110.92352238
46CAMK10.90687743
47CAMK2A0.88273088
48PAK30.86315906
49LIMK10.82821912
50WNK40.80524921
51ERBB20.77030382
52TNK20.70003948
53MAPK110.69517997
54LATS10.69017079
55BUB10.68812469
56CDC70.68577289
57ZAK0.64519659
58RPS6KA60.62327610
59TTK0.59889681
60CSNK1G20.59400805
61PDGFRB0.58096580
62VRK10.57833660
63CAMK1D0.56031023
64PRKCE0.55421379
65PRKCG0.52838767
66CDK90.52722413
67PTK2B0.52633191
68AKT20.50242192
69TLK10.48314749
70MARK20.48077737
71STK380.46688745
72PASK0.44875868
73SIK30.44337232
74TGFBR10.43920103
75DYRK1A0.42072043
76DYRK1B0.41615016
77UHMK10.40518686
78INSR0.40348314
79MAP3K70.40261158
80CSNK2A10.39865801
81EIF2AK30.39156452
82ERBB30.38071137
83ITK0.37651926
84RPS6KA20.36717011
85PRKG10.35352511
86NEK60.35001124
87NTRK20.34891380
88CAMK2G0.34667712
89RPS6KA10.34587303
90PBK0.34065354
91EPHA40.33408939
92MAP2K60.33397270
93RPS6KL10.33182477
94RPS6KC10.33182477
95ADRBK10.31443812
96PRKCB0.30226351
97PRKACA0.29627388
98CSNK1G30.29228745
99EGFR0.28710904
100PRKCA0.26645924

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.52469826
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16979937
3Protein export_Homo sapiens_hsa030603.05623851
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.00744499
5Homologous recombination_Homo sapiens_hsa034402.99381865
6Dorso-ventral axis formation_Homo sapiens_hsa043202.79203648
7Fatty acid elongation_Homo sapiens_hsa000622.78252365
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56564830
9Proteasome_Homo sapiens_hsa030502.47312642
10Phototransduction_Homo sapiens_hsa047442.45656374
11Butanoate metabolism_Homo sapiens_hsa006502.33508321
12Nitrogen metabolism_Homo sapiens_hsa009102.33376264
13Fatty acid biosynthesis_Homo sapiens_hsa000612.33170641
14Basal transcription factors_Homo sapiens_hsa030221.99015810
15Collecting duct acid secretion_Homo sapiens_hsa049661.94880968
16Mismatch repair_Homo sapiens_hsa034301.85389441
17RNA degradation_Homo sapiens_hsa030181.81385411
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74650511
19Oxidative phosphorylation_Homo sapiens_hsa001901.71675214
20Primary immunodeficiency_Homo sapiens_hsa053401.66771993
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64945251
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60546369
23Graft-versus-host disease_Homo sapiens_hsa053321.58623573
24Propanoate metabolism_Homo sapiens_hsa006401.54429465
25Huntingtons disease_Homo sapiens_hsa050161.41560425
26ABC transporters_Homo sapiens_hsa020101.41229036
27Parkinsons disease_Homo sapiens_hsa050121.36242872
28Nicotine addiction_Homo sapiens_hsa050331.31772786
29Selenocompound metabolism_Homo sapiens_hsa004501.29595669
30RNA polymerase_Homo sapiens_hsa030201.28435254
31Antigen processing and presentation_Homo sapiens_hsa046121.24811963
32Circadian rhythm_Homo sapiens_hsa047101.21566612
33Fatty acid degradation_Homo sapiens_hsa000711.17248146
34Nucleotide excision repair_Homo sapiens_hsa034201.16668210
35RNA transport_Homo sapiens_hsa030131.16093428
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16014389
37Olfactory transduction_Homo sapiens_hsa047401.13994459
38Morphine addiction_Homo sapiens_hsa050321.12789170
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06766622
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00749450
41Caffeine metabolism_Homo sapiens_hsa002320.98869898
42Retinol metabolism_Homo sapiens_hsa008300.93798519
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90104843
44Fatty acid metabolism_Homo sapiens_hsa012120.85615763
45Circadian entrainment_Homo sapiens_hsa047130.83213244
46Allograft rejection_Homo sapiens_hsa053300.79881128
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78098122
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77677626
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.75562282
50Peroxisome_Homo sapiens_hsa041460.75213302
51Chemical carcinogenesis_Homo sapiens_hsa052040.75134375
52One carbon pool by folate_Homo sapiens_hsa006700.74467457
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73140405
54Autoimmune thyroid disease_Homo sapiens_hsa053200.73054238
55Hematopoietic cell lineage_Homo sapiens_hsa046400.72421309
56Folate biosynthesis_Homo sapiens_hsa007900.71085788
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70612612
58Inositol phosphate metabolism_Homo sapiens_hsa005620.70424312
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69117698
60T cell receptor signaling pathway_Homo sapiens_hsa046600.66155089
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65380160
62Linoleic acid metabolism_Homo sapiens_hsa005910.63898782
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62840978
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62156240
65Taste transduction_Homo sapiens_hsa047420.60419995
66Calcium signaling pathway_Homo sapiens_hsa040200.59846582
67DNA replication_Homo sapiens_hsa030300.59603192
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59542605
69Hedgehog signaling pathway_Homo sapiens_hsa043400.58520683
70GABAergic synapse_Homo sapiens_hsa047270.57494445
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57123574
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56828026
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56464716
74Oocyte meiosis_Homo sapiens_hsa041140.56013084
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.55076943
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52077348
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51189850
78TGF-beta signaling pathway_Homo sapiens_hsa043500.50923861
79Salmonella infection_Homo sapiens_hsa051320.50741829
80Cholinergic synapse_Homo sapiens_hsa047250.49640644
81Alzheimers disease_Homo sapiens_hsa050100.48004973
82Rheumatoid arthritis_Homo sapiens_hsa053230.47610254
83beta-Alanine metabolism_Homo sapiens_hsa004100.47214693
84Ether lipid metabolism_Homo sapiens_hsa005650.45911286
85Metabolic pathways_Homo sapiens_hsa011000.43941075
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43234182
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.43067470
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.42788502
89Glutamatergic synapse_Homo sapiens_hsa047240.42437529
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39937864
91Serotonergic synapse_Homo sapiens_hsa047260.37136883
92Salivary secretion_Homo sapiens_hsa049700.36468628
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36246925
94Type I diabetes mellitus_Homo sapiens_hsa049400.34243072
95Melanoma_Homo sapiens_hsa052180.33091330
96Dopaminergic synapse_Homo sapiens_hsa047280.32000915
97Cardiac muscle contraction_Homo sapiens_hsa042600.28983491
98Pyrimidine metabolism_Homo sapiens_hsa002400.28517772
99Cell cycle_Homo sapiens_hsa041100.28341069
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28164617

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