ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	muscle filament sliding (GO:0030049)	5.98736767
2	actin-myosin filament sliding (GO:0033275)	5.98736767
3	regulation of skeletal muscle contraction (GO:0014819)	5.36379881
4	sarcoplasmic reticulum calcium ion transport (GO:0070296)	5.25117939
5	actin-mediated cell contraction (GO:0070252)	5.11011497
6	regulation of cilium movement (GO:0003352)	5.09487719
7	skeletal muscle contraction (GO:0003009)	5.00444943
8	male meiosis I (GO:0007141)	4.92780432
9	regulation of meiosis I (GO:0060631)	4.86857364
10	regulation of microtubule-based movement (GO:0060632)	4.76397743
11	piRNA metabolic process (GO:0034587)	4.67551179
12	synaptonemal complex organization (GO:0070193)	4.63653667
13	response to pheromone (GO:0019236)	4.54241754
14	male meiosis (GO:0007140)	4.45831397
15	synaptonemal complex assembly (GO:0007130)	4.38878229
16	DNA methylation involved in gamete generation (GO:0043046)	4.25974251
17	skeletal muscle fiber development (GO:0048741)	4.14669979
18	chromosome organization involved in meiosis (GO:0070192)	4.13120725
19	axonemal dynein complex assembly (GO:0070286)	4.01438425
20	negative regulation of inclusion body assembly (GO:0090084)	3.99601298
21	response to muscle activity (GO:0014850)	3.99509479
22	pyrimidine nucleobase catabolic process (GO:0006208)	3.97609370
23	synapsis (GO:0007129)	3.84305937
24	positive regulation of meiosis (GO:0045836)	3.83636104
25	sarcomere organization (GO:0045214)	3.80632094
26	acrosome reaction (GO:0007340)	3.75461159
27	somite development (GO:0061053)	3.71459826
28	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.70677752
29	myotube cell development (GO:0014904)	3.68907542
30	plasma membrane fusion (GO:0045026)	3.68722358
31	regulation of relaxation of muscle (GO:1901077)	3.68172164
32	nonmotile primary cilium assembly (GO:0035058)	3.67584193
33	meiosis I (GO:0007127)	3.65850948
34	spinal cord motor neuron differentiation (GO:0021522)	3.59749403
35	positive regulation of meiotic cell cycle (GO:0051446)	3.58717973
36	meiotic nuclear division (GO:0007126)	3.58072296
37	striatum development (GO:0021756)	3.56550265
38	striated muscle contraction (GO:0006941)	3.56523143
39	negative regulation of appetite (GO:0032099)	3.55623333
40	negative regulation of response to food (GO:0032096)	3.55623333
41	urinary tract smooth muscle contraction (GO:0014848)	3.53686535
42	actin filament-based movement (GO:0030048)	3.53513401
43	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	3.49922597
44	sequestering of actin monomers (GO:0042989)	3.47083889
45	artery smooth muscle contraction (GO:0014824)	3.43566675
46	alanine transport (GO:0032328)	3.43163555
47	DNA synthesis involved in DNA repair (GO:0000731)	3.42283878
48	brain morphogenesis (GO:0048854)	3.35654681
49	spermatid development (GO:0007286)	3.32919336
50	dopaminergic neuron differentiation (GO:0071542)	3.32651698
51	establishment of mitochondrion localization (GO:0051654)	3.32532204
52	positive regulation of protein depolymerization (GO:1901881)	3.30855265
53	protein polyglutamylation (GO:0018095)	3.30090662
54	behavioral response to cocaine (GO:0048148)	3.29927364
55	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.29901318
56	neuronal action potential propagation (GO:0019227)	3.29900230
57	sperm motility (GO:0030317)	3.29540394
58	creatine metabolic process (GO:0006600)	3.22827998
59	cilium or flagellum-dependent cell motility (GO:0001539)	3.22332933
60	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.20820596
61	mitochondrion transport along microtubule (GO:0047497)	3.20820596
62	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.18837070
63	response to nitrosative stress (GO:0051409)	3.16476419
64	intraciliary transport (GO:0042073)	3.14122193
65	myofibril assembly (GO:0030239)	3.09304577
66	regulation of NFAT protein import into nucleus (GO:0051532)	3.06217833
67	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.05989582
68	microtubule severing (GO:0051013)	3.05442762
69	muscle contraction (GO:0006936)	3.03400916
70	nucleobase catabolic process (GO:0046113)	3.03147975
71	cranial nerve morphogenesis (GO:0021602)	2.99697493
72	protein localization to cytoskeleton (GO:0044380)	2.95992342
73	skeletal muscle adaptation (GO:0043501)	2.95335175
74	spinal cord association neuron differentiation (GO:0021527)	2.95314102
75	tonic smooth muscle contraction (GO:0014820)	2.94381069
76	negative regulation of gene silencing (GO:0060969)	2.93920421
77	sex differentiation (GO:0007548)	2.92881471
78	axoneme assembly (GO:0035082)	2.89329294
79	regulation of response to food (GO:0032095)	2.87470706
80	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.86583962
81	regulation of cell communication by electrical coupling (GO:0010649)	2.86409017
82	retinal rod cell development (GO:0046548)	2.86383169
83	positive regulation of cellular response to oxidative stress (GO:1900409)	2.85242310
84	positive regulation of response to oxidative stress (GO:1902884)	2.85242310
85	muscle fiber development (GO:0048747)	2.84338164
86	glycogen catabolic process (GO:0005980)	2.82665882
87	regulation of membrane repolarization (GO:0060306)	2.82583963
88	muscle system process (GO:0003012)	2.80213062
89	spermatid nucleus differentiation (GO:0007289)	2.78264403
90	regulation of dopamine secretion (GO:0014059)	2.77069716
91	ventricular septum development (GO:0003281)	2.76588414
92	positive regulation of mitochondrial fission (GO:0090141)	2.72725111
93	cellular response to leptin stimulus (GO:0044320)	2.72416086
94	microtubule depolymerization (GO:0007019)	2.72028852
95	macroautophagy (GO:0016236)	2.71786015
96	epithelial cilium movement (GO:0003351)	2.65421148
97	regulation of inclusion body assembly (GO:0090083)	2.64987341
98	postsynaptic membrane organization (GO:0001941)	2.63627550
99	regulation of phospholipid biosynthetic process (GO:0071071)	2.63618019
100	neuromuscular synaptic transmission (GO:0007274)	2.62599919

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.80046815
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.81543800
3	VDR_22108803_ChIP-Seq_LS180_Human	2.48849976
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42536170
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.34810372
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.27196266
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.14049594
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07487153
9	RNF2_27304074_Chip-Seq_NSC_Mouse	2.00574069
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00012099
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98359791
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.98027891
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.95013682
14	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.82538962
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.80124267
16	CBP_20019798_ChIP-Seq_JUKART_Human	1.78736670
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.78736670
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.78536404
19	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.78501667
20	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.77650283
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.72842249
22	FUS_26573619_Chip-Seq_HEK293_Human	1.72660230
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.71749296
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.70187539
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.70078942
26	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63816415
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63816415
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.62085504
29	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.59273105
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59266161
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58706204
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.53351605
33	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.52901165
34	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.52028270
35	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.51659572
36	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.49465472
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.48549476
38	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.47962716
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.44040488
40	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.42847318
41	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.42410509
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.41140378
43	P300_19829295_ChIP-Seq_ESCs_Human	1.39700736
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39428933
45	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.39009379
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37637397
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37542839
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35768743
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.34214254
50	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.34000440
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32495590
52	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.32404774
53	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.32372793
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31986451
55	AR_25329375_ChIP-Seq_VCAP_Human	1.30082267
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29855169
57	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.28043421
58	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.28043421
59	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25260484
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.24956403
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23610229
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19372240
63	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.15928138
64	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15345386
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14228226
66	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12259916
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11062809
68	STAT3_23295773_ChIP-Seq_U87_Human	1.10690393
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10104675
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05815606
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02702998
72	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02403156
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01512061
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.01176590
75	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01151355
76	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.00477499
77	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.99803742
78	TBL1_22424771_ChIP-Seq_293T_Human	0.99703884
79	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.99695064
80	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99128247
81	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.98832553
82	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97717443
83	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97717443
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97037394
85	TCF4_23295773_ChIP-Seq_U87_Human	0.95749874
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94144611
87	CTCF_27219007_Chip-Seq_Bcells_Human	0.92863492
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92756464
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92631229
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91610695
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91068788
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89689705
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89419855
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.89281783
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89143808
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.89103581
97	SOX9_26525672_Chip-Seq_HEART_Mouse	0.88780404
98	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.88503578
99	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.87802364
100	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.87473499

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	5.51647038
2	MP0004145_abnormal_muscle_electrophysio	4.57289671
3	MP0002822_catalepsy	3.74488323
4	MP0000566_synostosis	3.32020221
5	MP0000749_muscle_degeneration	3.22270813
6	MP0000751_myopathy	3.14697691
7	MP0001529_abnormal_vocalization	2.54825187
8	MP0008789_abnormal_olfactory_epithelium	2.51708317
9	MP0004036_abnormal_muscle_relaxation	2.50210005
10	MP0002106_abnormal_muscle_physiology	2.31294463
11	MP0005410_abnormal_fertilization	2.20931664
12	MP0001984_abnormal_olfaction	2.13467036
13	MP0008877_abnormal_DNA_methylation	2.02060885
14	MP0005369_muscle_phenotype	1.97797701
15	MP0002269_muscular_atrophy	1.89156786
16	MP0009379_abnormal_foot_pigmentation	1.85871767
17	MP0000750_abnormal_muscle_regeneration	1.83300681
18	MP0000759_abnormal_skeletal_muscle	1.82419786
19	MP0005394_taste/olfaction_phenotype	1.79362106
20	MP0005499_abnormal_olfactory_system	1.79362106
21	MP0003698_abnormal_male_reproductive	1.78687541
22	MP0003938_abnormal_ear_development	1.75026897
23	MP0004270_analgesia	1.70905299
24	MP0005620_abnormal_muscle_contractility	1.70315136
25	MP0002102_abnormal_ear_morphology	1.69188345
26	MP0004087_abnormal_muscle_fiber	1.68558013
27	MP0003122_maternal_imprinting	1.65706890
28	MP0002734_abnormal_mechanical_nocicepti	1.65050891
29	MP0006036_abnormal_mitochondrial_physio	1.59788019
30	MP0004233_abnormal_muscle_weight	1.57264937
31	MP0004742_abnormal_vestibular_system	1.57029452
32	MP0000747_muscle_weakness	1.56810556
33	MP0001929_abnormal_gametogenesis	1.52719919
34	MP0002837_dystrophic_cardiac_calcinosis	1.50122679
35	MP0002210_abnormal_sex_determination	1.48157245
36	MP0003136_yellow_coat_color	1.42549222
37	MP0002332_abnormal_exercise_endurance	1.37677260
38	MP0001440_abnormal_grooming_behavior	1.35765805
39	MP0004142_abnormal_muscle_tone	1.30177725
40	MP0003315_abnormal_perineum_morphology	1.25203925
41	MP0008995_early_reproductive_senescence	1.24642075
42	MP0003635_abnormal_synaptic_transmissio	1.23514480
43	MP0005409_darkened_coat_color	1.23487540
44	MP0000026_abnormal_inner_ear	1.22999291
45	MP0004130_abnormal_muscle_cell	1.21174714
46	MP0002572_abnormal_emotion/affect_behav	1.15124392
47	MP0002108_abnormal_muscle_morphology	1.15066603
48	MP0004084_abnormal_cardiac_muscle	1.13730320
49	MP0006276_abnormal_autonomic_nervous	1.12805980
50	MP0002735_abnormal_chemical_nociception	1.11213163
51	MP0005423_abnormal_somatic_nervous	1.11104538
52	MP0002067_abnormal_sensory_capabilities	1.10199855
53	MP0002132_abnormal_respiratory_system	1.08492487
54	MP0003879_abnormal_hair_cell	1.08225573
55	MP0004215_abnormal_myocardial_fiber	1.07864333
56	MP0005187_abnormal_penis_morphology	1.07509144
57	MP0001188_hyperpigmentation	1.06704022
58	MP0002557_abnormal_social/conspecific_i	1.06481431
59	MP0002638_abnormal_pupillary_reflex	1.05224979
60	MP0002272_abnormal_nervous_system	1.04792711
61	MP0002063_abnormal_learning/memory/cond	1.04495498
62	MP0003283_abnormal_digestive_organ	1.03135298
63	MP0003121_genomic_imprinting	1.02602283
64	MP0001145_abnormal_male_reproductive	1.01230053
65	MP0002972_abnormal_cardiac_muscle	1.00636859
66	MP0002909_abnormal_adrenal_gland	1.00541050
67	MP0005386_behavior/neurological_phenoty	0.98207998
68	MP0004924_abnormal_behavior	0.98207998
69	MP0005645_abnormal_hypothalamus_physiol	0.94137961
70	MP0001486_abnormal_startle_reflex	0.93538746
71	MP0005377_hearing/vestibular/ear_phenot	0.91258033
72	MP0003878_abnormal_ear_physiology	0.91258033
73	MP0009745_abnormal_behavioral_response	0.90714181
74	MP0002160_abnormal_reproductive_system	0.90319018
75	MP0000778_abnormal_nervous_system	0.89693017
76	MP0003942_abnormal_urinary_system	0.89419496
77	MP0004859_abnormal_synaptic_plasticity	0.88716684
78	MP0000653_abnormal_sex_gland	0.88314258
79	MP0005551_abnormal_eye_electrophysiolog	0.87302610
80	MP0005670_abnormal_white_adipose	0.86996463
81	MP0002064_seizures	0.85755782
82	MP0003119_abnormal_digestive_system	0.82986838
83	MP0003011_delayed_dark_adaptation	0.82926794
84	MP0004484_altered_response_of	0.82780920
85	MP0002184_abnormal_innervation	0.82549500
86	MP0003329_amyloid_beta_deposits	0.80816429
87	MP0001485_abnormal_pinna_reflex	0.80648994
88	MP0001970_abnormal_pain_threshold	0.79830358
89	MP0005330_cardiomyopathy	0.79763874
90	MP0002161_abnormal_fertility/fecundity	0.79751877
91	MP0000733_abnormal_muscle_development	0.79557628
92	MP0000049_abnormal_middle_ear	0.78522162
93	MP0000013_abnormal_adipose_tissue	0.78165586
94	MP0002127_abnormal_cardiovascular_syste	0.77258461
95	MP0002234_abnormal_pharynx_morphology	0.77101644
96	MP0004085_abnormal_heartbeat	0.76162042
97	MP0000955_abnormal_spinal_cord	0.76038985
98	MP0002066_abnormal_motor_capabilities/c	0.74222077
99	MP0003937_abnormal_limbs/digits/tail_de	0.71799132
100	MP0009046_muscle_twitch	0.71608734

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nemaline bodies (HP:0003798)	8.05522717
2	Muscle fiber inclusion bodies (HP:0100299)	8.01540367
3	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	7.78040584
4	Exercise-induced muscle cramps (HP:0003710)	5.70957235
5	Type 1 muscle fiber predominance (HP:0003803)	5.47833782
6	Exercise-induced myalgia (HP:0003738)	5.47808824
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.39715936
8	Rimmed vacuoles (HP:0003805)	4.93614016
9	Muscle hypertrophy of the lower extremities (HP:0008968)	4.72287178
10	Calf muscle hypertrophy (HP:0008981)	4.08505135
11	Absent phalangeal crease (HP:0006109)	3.83020897
12	Myopathic facies (HP:0002058)	3.68881085
13	Muscle fiber splitting (HP:0003555)	3.67758754
14	Distal arthrogryposis (HP:0005684)	3.61782324
15	EMG: myopathic abnormalities (HP:0003458)	3.56386340
16	Abnormal respiratory motile cilium physiology (HP:0012261)	3.49786399
17	Calcaneovalgus deformity (HP:0001848)	3.44718837
18	Myoglobinuria (HP:0002913)	3.42966482
19	Myotonia (HP:0002486)	3.30738721
20	Rhabdomyolysis (HP:0003201)	3.25236182
21	Chronic bronchitis (HP:0004469)	3.23126434
22	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.19706438
23	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.19706438
24	Hyperkalemia (HP:0002153)	3.17685757
25	Abnormal finger flexion creases (HP:0006143)	3.06403122
26	Deformed tarsal bones (HP:0008119)	3.02796370
27	Abnormality of the calf musculature (HP:0001430)	3.01684508
28	Shoulder girdle muscle weakness (HP:0003547)	3.01001062
29	Rhinitis (HP:0012384)	2.90985900
30	Hyporeflexia of lower limbs (HP:0002600)	2.89572797
31	Round ear (HP:0100830)	2.77851387
32	Ulnar deviation of the wrist (HP:0003049)	2.62483117
33	Abnormality of skeletal muscle fiber size (HP:0012084)	2.57968997
34	Subaortic stenosis (HP:0001682)	2.57925046
35	Abnormality of the left ventricular outflow tract (HP:0011103)	2.57925046
36	Gait imbalance (HP:0002141)	2.57109448
37	Abnormality of the calcaneus (HP:0008364)	2.54658817
38	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.53485863
39	Abnormality of the corticospinal tract (HP:0002492)	2.50438759
40	Limb dystonia (HP:0002451)	2.47758300
41	Frequent falls (HP:0002359)	2.43573346
42	Fetal akinesia sequence (HP:0001989)	2.43357691
43	Neck muscle weakness (HP:0000467)	2.42861743
44	Asymmetric septal hypertrophy (HP:0001670)	2.31362615
45	Muscle stiffness (HP:0003552)	2.30818142
46	Difficulty running (HP:0009046)	2.28948592
47	Sudden death (HP:0001699)	2.28705615
48	Type I transferrin isoform profile (HP:0003642)	2.27376201
49	Mesomelia (HP:0003027)	2.22847808
50	Amyotrophic lateral sclerosis (HP:0007354)	2.19833421
51	Myokymia (HP:0002411)	2.13433711
52	Weak cry (HP:0001612)	2.12280006
53	Abnormal ciliary motility (HP:0012262)	2.11755031
54	Urinary urgency (HP:0000012)	2.09433523
55	EMG: neuropathic changes (HP:0003445)	2.06714002
56	Limb-girdle muscle weakness (HP:0003325)	2.00366621
57	Polyphagia (HP:0002591)	1.95958401
58	Increased variability in muscle fiber diameter (HP:0003557)	1.95926337
59	Impaired vibration sensation in the lower limbs (HP:0002166)	1.95591583
60	Abnormal sex determination (HP:0012244)	1.91712370
61	Sex reversal (HP:0012245)	1.91712370
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.89307895
63	Absent/shortened dynein arms (HP:0200106)	1.89307895
64	Malignant hyperthermia (HP:0002047)	1.89194757
65	Progressive cerebellar ataxia (HP:0002073)	1.86794536
66	Genetic anticipation (HP:0003743)	1.86119212
67	Congenital primary aphakia (HP:0007707)	1.82901041
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.82130264
69	Abnormal respiratory motile cilium morphology (HP:0005938)	1.82130264
70	Generalized muscle weakness (HP:0003324)	1.81990990
71	Disinhibition (HP:0000734)	1.80443048
72	Bulbar palsy (HP:0001283)	1.77610578
73	Distal lower limb muscle weakness (HP:0009053)	1.75917226
74	Medial flaring of the eyebrow (HP:0010747)	1.74302495
75	Retinal atrophy (HP:0001105)	1.73551047
76	Abnormality of the shoulder girdle musculature (HP:0001435)	1.73359113
77	Progressive macrocephaly (HP:0004481)	1.73133366
78	Atonic seizures (HP:0010819)	1.72278317
79	Acute necrotizing encephalopathy (HP:0006965)	1.71385753
80	Nephrogenic diabetes insipidus (HP:0009806)	1.70868356
81	Abnormal protein glycosylation (HP:0012346)	1.70807383
82	Abnormal glycosylation (HP:0012345)	1.70807383
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.70807383
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.70807383
85	Abnormality of the musculature of the pelvis (HP:0001469)	1.69316110
86	Abnormality of the hip-girdle musculature (HP:0001445)	1.69316110
87	Muscular dystrophy (HP:0003560)	1.69243839
88	Genital tract atresia (HP:0001827)	1.68683474
89	Limb-girdle muscle atrophy (HP:0003797)	1.68557223
90	Pelvic girdle muscle weakness (HP:0003749)	1.68082349
91	Waddling gait (HP:0002515)	1.67222036
92	Resting tremor (HP:0002322)	1.66188481
93	Vaginal atresia (HP:0000148)	1.64960658
94	Midline defect of the nose (HP:0004122)	1.62648993
95	Abnormality of the neuromuscular junction (HP:0003398)	1.62546499
96	Fatigable weakness (HP:0003473)	1.62546499
97	Long clavicles (HP:0000890)	1.62087893
98	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.59774196
99	Exercise intolerance (HP:0003546)	1.59359894
100	Bilateral microphthalmos (HP:0007633)	1.59245807

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.13545131
2	OBSCN	4.96517697
3	WNK3	4.61498928
4	PHKG2	4.60344851
5	PHKG1	4.60344851
6	MARK1	4.27853922
7	CASK	3.39449995
8	PINK1	2.95505572
9	TTN	2.33967186
10	CDK19	2.15507606
11	PLK2	2.08656591
12	MAPK13	2.01022509
13	DYRK2	1.79858403
14	EPHB2	1.79249589
15	MAPK12	1.60599513
16	FES	1.57088325
17	MET	1.55196595
18	BMPR1B	1.53360617
19	TNIK	1.49986193
20	PTK2B	1.37119464
21	NTRK2	1.31630434
22	MAP2K4	1.29157357
23	FER	1.23955212
24	TESK1	1.17616330
25	MAPK15	1.08337087
26	CAMK1G	1.06731491
27	MAP3K4	1.00611395
28	KSR1	0.97922689
29	MAP2K7	0.97407728
30	MAP3K10	0.96778513
31	CAMK1	0.96471343
32	LIMK1	0.94652296
33	PRKD3	0.89618705
34	UHMK1	0.87945371
35	PIK3CG	0.86251663
36	BMX	0.85555314
37	NTRK3	0.85404266
38	BCR	0.82277544
39	MAP3K9	0.81998816
40	CAMK2G	0.77847258
41	MAP2K6	0.77770560
42	OXSR1	0.77566609
43	PKN1	0.76658470
44	NME1	0.74530943
45	CAMK2A	0.73082313
46	MUSK	0.71681447
47	DYRK1B	0.70758493
48	DYRK1A	0.69746916
49	FGR	0.68558579
50	STK38	0.64610422
51	CAMK2B	0.61135283
52	MINK1	0.60259945
53	STK38L	0.56930463
54	PRKG1	0.55999440
55	MOS	0.53673871
56	CAMK2D	0.53400230
57	SGK1	0.52074176
58	AKT2	0.50119744
59	MAPKAPK3	0.48940133
60	PRKCE	0.48519319
61	WEE1	0.48257558
62	ROCK1	0.47838489
63	CDK14	0.47606187
64	TAOK1	0.47591478
65	AKT3	0.47232777
66	SGK2	0.45733751
67	ERBB3	0.44408575
68	CDK5	0.42335398
69	PLK4	0.41109592
70	CDK11A	0.40828891
71	MARK2	0.40404194
72	PRKAA1	0.39246382
73	BCKDK	0.38858392
74	ABL2	0.38826202
75	MAP2K1	0.38557979
76	SGK494	0.38234070
77	SGK223	0.38234070
78	BRAF	0.37111650
79	MAPK4	0.35538247
80	TSSK6	0.35499577
81	NEK9	0.35365215
82	DAPK2	0.34402844
83	PRKCG	0.33815055
84	ZAK	0.32534287
85	PRKACA	0.31211411
86	DYRK3	0.31109712
87	MAPKAPK5	0.28507555
88	TRIM28	0.28080852
89	RPS6KA3	0.27783207
90	PRKCZ	0.27123824
91	GRK1	0.26658896
92	CSNK1E	0.26299345
93	MAPK7	0.24770476
94	CSF1R	0.24405363
95	CSNK1G2	0.24296787
96	CSNK1D	0.22806540
97	PRKACB	0.22720570
98	TGFBR1	0.22625809
99	CDK3	0.21635152
100	RPS6KB1	0.21530831

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cardiac muscle contraction_Homo sapiens_hsa04260	3.77656828
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.49297170
3	Parkinsons disease_Homo sapiens_hsa05012	2.67848890
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.36198120
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32897827
6	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.25852081
7	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.24483141
8	Steroid biosynthesis_Homo sapiens_hsa00100	1.93536027
9	Sulfur relay system_Homo sapiens_hsa04122	1.90756915
10	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.82778835
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.81742288
12	Alzheimers disease_Homo sapiens_hsa05010	1.80857967
13	Folate biosynthesis_Homo sapiens_hsa00790	1.73331927
14	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.67198306
15	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.66771864
16	Circadian rhythm_Homo sapiens_hsa04710	1.64944883
17	Huntingtons disease_Homo sapiens_hsa05016	1.62054222
18	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.59906326
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.52225621
20	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.49094542
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.46665360
22	Nicotine addiction_Homo sapiens_hsa05033	1.40851409
23	Phototransduction_Homo sapiens_hsa04744	1.40574189
24	Gap junction_Homo sapiens_hsa04540	1.39976459
25	Propanoate metabolism_Homo sapiens_hsa00640	1.39878213
26	GABAergic synapse_Homo sapiens_hsa04727	1.39018673
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38901550
28	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.36447691
29	Gastric acid secretion_Homo sapiens_hsa04971	1.35847457
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.34317211
31	Arginine and proline metabolism_Homo sapiens_hsa00330	1.33819533
32	Butanoate metabolism_Homo sapiens_hsa00650	1.31771091
33	Basal cell carcinoma_Homo sapiens_hsa05217	1.28751008
34	Olfactory transduction_Homo sapiens_hsa04740	1.28467560
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.23171516
36	Morphine addiction_Homo sapiens_hsa05032	1.22838088
37	Serotonergic synapse_Homo sapiens_hsa04726	1.21371699
38	Circadian entrainment_Homo sapiens_hsa04713	1.21115753
39	Phenylalanine metabolism_Homo sapiens_hsa00360	1.20755449
40	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.20455033
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.17125676
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16788135
43	Glucagon signaling pathway_Homo sapiens_hsa04922	1.15946954
44	Cholinergic synapse_Homo sapiens_hsa04725	1.11995455
45	Melanogenesis_Homo sapiens_hsa04916	1.02296181
46	AMPK signaling pathway_Homo sapiens_hsa04152	1.00676635
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.99188016
48	Regulation of autophagy_Homo sapiens_hsa04140	0.96385491
49	Oocyte meiosis_Homo sapiens_hsa04114	0.95531512
50	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.91403622
51	Insulin signaling pathway_Homo sapiens_hsa04910	0.90687749
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.90561972
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.83263986
54	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.83018647
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82104593
56	Taste transduction_Homo sapiens_hsa04742	0.81642774
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81608167
58	Insulin secretion_Homo sapiens_hsa04911	0.79969653
59	Axon guidance_Homo sapiens_hsa04360	0.79520513
60	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.79037371
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73344521
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.72197790
63	Peroxisome_Homo sapiens_hsa04146	0.70381014
64	Fatty acid degradation_Homo sapiens_hsa00071	0.68928956
65	Tight junction_Homo sapiens_hsa04530	0.68738292
66	Cocaine addiction_Homo sapiens_hsa05030	0.65296422
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.65211347
68	Alcoholism_Homo sapiens_hsa05034	0.65166846
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.64569298
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.64255173
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.63690223
72	Hippo signaling pathway_Homo sapiens_hsa04390	0.61863208
73	Estrogen signaling pathway_Homo sapiens_hsa04915	0.61124067
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59791330
75	MAPK signaling pathway_Homo sapiens_hsa04010	0.58569637
76	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57183227
77	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.56988206
78	Carbon metabolism_Homo sapiens_hsa01200	0.56689973
79	Long-term potentiation_Homo sapiens_hsa04720	0.54597707
80	Wnt signaling pathway_Homo sapiens_hsa04310	0.53348418
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53258238
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52539698
83	Amphetamine addiction_Homo sapiens_hsa05031	0.51641574
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.51551814
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.51544031
86	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.51427144
87	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.50835400
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.50455939
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49804007
90	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.48578113
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.48255824
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46139837
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42386269
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.41729518
95	Renin secretion_Homo sapiens_hsa04924	0.40419124
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40360017
97	Fanconi anemia pathway_Homo sapiens_hsa03460	0.39665669
98	Pancreatic secretion_Homo sapiens_hsa04972	0.39410149
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38646005
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37764880

OR7E29P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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