

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of T-helper 2 cell differentiation (GO:0045628) | 9.96706542 |
| 2 | activation of protein kinase A activity (GO:0034199) | 9.91130773 |
| 3 | positive regulation of RNA splicing (GO:0033120) | 9.55164228 |
| 4 | seminiferous tubule development (GO:0072520) | 9.51467918 |
| 5 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 9.10234491 |
| 6 | cAMP biosynthetic process (GO:0006171) | 8.68740073 |
| 7 | detection of chemical stimulus involved in sensory perception (GO:0050907) | 8.43630949 |
| 8 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 8.28088741 |
| 9 | enteric nervous system development (GO:0048484) | 7.84701940 |
| 10 | regulation of protein sumoylation (GO:0033233) | 7.53239629 |
| 11 | righting reflex (GO:0060013) | 7.00604820 |
| 12 | positive regulation of mitochondrial fission (GO:0090141) | 6.96982202 |
| 13 | synaptic transmission, dopaminergic (GO:0001963) | 6.96368560 |
| 14 | dendritic spine morphogenesis (GO:0060997) | 6.85270552 |
| 15 | heterotypic cell-cell adhesion (GO:0034113) | 6.57476140 |
| 16 | positive regulation of T-helper 1 type immune response (GO:0002827) | 6.31929464 |
| 17 | arachidonic acid secretion (GO:0050482) | 6.11781886 |
| 18 | icosanoid secretion (GO:0032309) | 6.11781886 |
| 19 | detection of chemical stimulus (GO:0009593) | 6.05939222 |
| 20 | endothelial cell differentiation (GO:0045446) | 5.90406873 |
| 21 | hepatocyte apoptotic process (GO:0097284) | 5.89171815 |
| 22 | positive regulation of T-helper cell differentiation (GO:0045624) | 5.72137578 |
| 23 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 5.44865449 |
| 24 | drug transmembrane transport (GO:0006855) | 5.32163116 |
| 25 | regulation of mitochondrial fission (GO:0090140) | 5.13060067 |
| 26 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 5.09037566 |
| 27 | fatty acid derivative transport (GO:1901571) | 5.06217496 |
| 28 | icosanoid transport (GO:0071715) | 5.06217496 |
| 29 | negative regulation of alpha-beta T cell activation (GO:0046636) | 5.03559332 |
| 30 | phosphatidylglycerol acyl-chain remodeling (GO:0036148) | 4.93227377 |
| 31 | neuronal ion channel clustering (GO:0045161) | 4.89249898 |
| 32 | neural tube formation (GO:0001841) | 4.76840383 |
| 33 | chemosensory behavior (GO:0007635) | 4.71708749 |
| 34 | embryonic digestive tract morphogenesis (GO:0048557) | 4.60051644 |
| 35 | hyaluronan catabolic process (GO:0030214) | 4.58701919 |
| 36 | regulation of T-helper 1 type immune response (GO:0002825) | 4.56376478 |
| 37 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.51264701 |
| 38 | nephron epithelium morphogenesis (GO:0072088) | 4.45673962 |
| 39 | nephron tubule morphogenesis (GO:0072078) | 4.45673962 |
| 40 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 4.38095817 |
| 41 | ATP hydrolysis coupled proton transport (GO:0015991) | 4.34110068 |
| 42 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 4.34110068 |
| 43 | cyclic purine nucleotide metabolic process (GO:0052652) | 4.31197572 |
| 44 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.28220362 |
| 45 | retina layer formation (GO:0010842) | 4.26727100 |
| 46 | vocalization behavior (GO:0071625) | 4.24169022 |
| 47 | regulation of T-helper cell differentiation (GO:0045622) | 4.18142558 |
| 48 | cyclic nucleotide biosynthetic process (GO:0009190) | 4.17172079 |
| 49 | negative regulation of actin filament bundle assembly (GO:0032232) | 4.16439052 |
| 50 | positive regulation of membrane potential (GO:0045838) | 4.15812835 |
| 51 | regulation of type 2 immune response (GO:0002828) | 4.12013698 |
| 52 | regulation of cAMP-mediated signaling (GO:0043949) | 4.11909215 |
| 53 | response to dietary excess (GO:0002021) | 4.10201226 |
| 54 | cellular response to glucagon stimulus (GO:0071377) | 4.09703451 |
| 55 | water transport (GO:0006833) | 3.99947472 |
| 56 | mitochondrial fusion (GO:0008053) | 3.91508978 |
| 57 | cAMP metabolic process (GO:0046058) | 3.91183176 |
| 58 | dendritic spine organization (GO:0097061) | 3.89753135 |
| 59 | protein localization to synapse (GO:0035418) | 3.88864443 |
| 60 | negative regulation of T cell differentiation (GO:0045581) | 3.88369637 |
| 61 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 3.86862019 |
| 62 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.84517938 |
| 63 | monoamine transport (GO:0015844) | 3.75181369 |
| 64 | cellular zinc ion homeostasis (GO:0006882) | 3.72816786 |
| 65 | drug transport (GO:0015893) | 3.69258079 |
| 66 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.67307502 |
| 67 | phosphatidylethanolamine acyl-chain remodeling (GO:0036152) | 3.59907747 |
| 68 | fluid transport (GO:0042044) | 3.58575944 |
| 69 | leukotriene biosynthetic process (GO:0019370) | 3.53106625 |
| 70 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043) | 3.48088602 |
| 71 | sulfur amino acid catabolic process (GO:0000098) | 3.43647397 |
| 72 | positive regulation of protein targeting to membrane (GO:0090314) | 3.42176318 |
| 73 | cellular response to ATP (GO:0071318) | 3.38224653 |
| 74 | pre-miRNA processing (GO:0031054) | 3.38155273 |
| 75 | sequestering of metal ion (GO:0051238) | 3.37909646 |
| 76 | neuromuscular process controlling posture (GO:0050884) | 3.37541779 |
| 77 | left/right axis specification (GO:0070986) | 3.34079529 |
| 78 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 3.33232706 |
| 79 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.31357221 |
| 80 | positive regulation of alpha-beta T cell differentiation (GO:0046638) | 3.30974284 |
| 81 | renal tubule morphogenesis (GO:0061333) | 3.18471509 |
| 82 | negative regulation of hydrogen peroxide-induced cell death (GO:1903206) | 3.14768691 |
| 83 | negative regulation of astrocyte differentiation (GO:0048712) | 3.13708560 |
| 84 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.13102072 |
| 85 | phosphatidylcholine acyl-chain remodeling (GO:0036151) | 3.11417589 |
| 86 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.04900515 |
| 87 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052 | 3.04417538 |
| 88 | positive regulation of steroid hormone secretion (GO:2000833) | 3.03933179 |
| 89 | adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) | 3.03202663 |
| 90 | reflex (GO:0060004) | 3.02413644 |
| 91 | response to glucagon (GO:0033762) | 3.02342414 |
| 92 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193) | 3.01548732 |
| 93 | tooth mineralization (GO:0034505) | 14.2666729 |
| 94 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 13.5795999 |
| 95 | positive regulation of protein sumoylation (GO:0033235) | 11.9436650 |
| 96 | negative regulation of T-helper cell differentiation (GO:0045623) | 11.2831714 |
| 97 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 11.2831714 |
| 98 | protein K11-linked deubiquitination (GO:0035871) | 10.5113250 |
| 99 | regulation of T-helper 1 cell differentiation (GO:0045625) | 10.2010689 |
| 100 | negative regulation of type 2 immune response (GO:0002829) | 10.0173195 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 6.79473480 |
| 2 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 5.38733438 |
| 3 | IGF1R_20145208_ChIP-Seq_DFB_Human | 4.70537981 |
| 4 | AR_21572438_ChIP-Seq_LNCaP_Human | 4.68606463 |
| 5 | VDR_22108803_ChIP-Seq_LS180_Human | 4.24290133 |
| 6 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 3.34048886 |
| 7 | TP53_16413492_ChIP-PET_HCT116_Human | 2.21073694 |
| 8 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 2.04439579 |
| 9 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 10.4476931 |
| 10 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.95778240 |
| 11 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.90984313 |
| 12 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.86514862 |
| 13 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.86514862 |
| 14 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.83790196 |
| 15 | GATA1_19941826_ChIP-Seq_K562_Human | 1.72967866 |
| 16 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.63572553 |
| 17 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.62436699 |
| 18 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.60644532 |
| 19 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.57548308 |
| 20 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.57103771 |
| 21 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.54507099 |
| 22 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.47346774 |
| 23 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.45204390 |
| 24 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.44942278 |
| 25 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.41599212 |
| 26 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.41210642 |
| 27 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.40458745 |
| 28 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.39695803 |
| 29 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.37776123 |
| 30 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.36775984 |
| 31 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.33877097 |
| 32 | RXR_22108803_ChIP-Seq_LS180_Human | 1.26829660 |
| 33 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.26716860 |
| 34 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.26209506 |
| 35 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.22789324 |
| 36 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.19887287 |
| 37 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.17468338 |
| 38 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.17313517 |
| 39 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.16244115 |
| 40 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.15886068 |
| 41 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.14226571 |
| 42 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.13878790 |
| 43 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.13067031 |
| 44 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.12696112 |
| 45 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.12369913 |
| 46 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.11441768 |
| 47 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.09318086 |
| 48 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.08790553 |
| 49 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.08492115 |
| 50 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.08379043 |
| 51 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.05411815 |
| 52 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.05304743 |
| 53 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.05108369 |
| 54 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.04346592 |
| 55 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.03934939 |
| 56 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.03765144 |
| 57 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.03687822 |
| 58 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.03489016 |
| 59 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.03412872 |
| 60 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.02988967 |
| 61 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.02610437 |
| 62 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.99129649 |
| 63 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.98530957 |
| 64 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.98454461 |
| 65 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.97313040 |
| 66 | TBL1_22424771_ChIP-Seq_293T_Human | 0.96651100 |
| 67 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95200845 |
| 68 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.94924393 |
| 69 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.94836255 |
| 70 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.94775101 |
| 71 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.94500391 |
| 72 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.92829991 |
| 73 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.92509743 |
| 74 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.90815291 |
| 75 | STAT3_23295773_ChIP-Seq_U87_Human | 0.90589580 |
| 76 | CJUN_26792858_Chip-Seq_BT549_Human | 0.88747061 |
| 77 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.88529833 |
| 78 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.88454614 |
| 79 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.87235823 |
| 80 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.86865518 |
| 81 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.85259315 |
| 82 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.84788284 |
| 83 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.84239584 |
| 84 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.83943383 |
| 85 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.83943383 |
| 86 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.83021444 |
| 87 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.82807781 |
| 88 | REST_21632747_ChIP-Seq_MESCs_Mouse | 0.82699529 |
| 89 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.82155937 |
| 90 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.81696888 |
| 91 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.81592558 |
| 92 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.81563373 |
| 93 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.80158058 |
| 94 | NANOG_16518401_ChIP-PET_MESCs_Mouse | 0.80007411 |
| 95 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.77892000 |
| 96 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.77131857 |
| 97 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.77075076 |
| 98 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.77000102 |
| 99 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.76701199 |
| 100 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.76359792 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008961_abnormal_basal_metabolism | 9.63913479 |
| 2 | MP0004130_abnormal_muscle_cell | 4.88780828 |
| 3 | MP0004264_abnormal_extraembryonic_tissu | 3.80124714 |
| 4 | MP0003252_abnormal_bile_duct | 3.63236078 |
| 5 | MP0002928_abnormal_bile_duct | 2.77335460 |
| 6 | MP0004133_heterotaxia | 2.73524605 |
| 7 | MP0006072_abnormal_retinal_apoptosis | 2.53880311 |
| 8 | MP0005408_hypopigmentation | 2.34038699 |
| 9 | MP0005448_abnormal_energy_balance | 2.25157038 |
| 10 | MP0002751_abnormal_autonomic_nervous | 2.24686598 |
| 11 | MP0003329_amyloid_beta_deposits | 2.14193447 |
| 12 | MP0001270_distended_abdomen | 2.05308401 |
| 13 | MP0005084_abnormal_gallbladder_morpholo | 12.5620463 |
| 14 | MP0004272_abnormal_basement_membrane | 1.97701861 |
| 15 | MP0003943_abnormal_hepatobiliary_system | 1.70209123 |
| 16 | MP0005220_abnormal_exocrine_pancreas | 1.58173780 |
| 17 | MP0005379_endocrine/exocrine_gland_phen | 1.57219850 |
| 18 | MP0005165_increased_susceptibility_to | 1.53456774 |
| 19 | MP0009764_decreased_sensitivity_to | 1.42894205 |
| 20 | MP0001958_emphysema | 1.42372510 |
| 21 | MP0000604_amyloidosis | 1.41853092 |
| 22 | MP0001529_abnormal_vocalization | 1.38063037 |
| 23 | MP0003718_maternal_effect | 1.25758160 |
| 24 | MP0001905_abnormal_dopamine_level | 1.15124091 |
| 25 | MP0005646_abnormal_pituitary_gland | 1.14184349 |
| 26 | MP0008569_lethality_at_weaning | 1.04369050 |
| 27 | MP0000465_gastrointestinal_hemorrhage | 1.01560705 |
| 28 | MP0000470_abnormal_stomach_morphology | 1.01162940 |
| 29 | MP0002572_abnormal_emotion/affect_behav | 1.00667828 |
| 30 | MP0003638_abnormal_response/metabolism_ | 0.97517514 |
| 31 | MP0002909_abnormal_adrenal_gland | 0.93938301 |
| 32 | MP0001944_abnormal_pancreas_morphology | 0.93732073 |
| 33 | MP0002405_respiratory_system_inflammati | 0.85671317 |
| 34 | MP0001800_abnormal_humoral_immune | 0.84087894 |
| 35 | MP0000371_diluted_coat_color | 0.82348550 |
| 36 | MP0001790_abnormal_immune_system | 0.81142156 |
| 37 | MP0005387_immune_system_phenotype | 0.81142156 |
| 38 | MP0008469_abnormal_protein_level | 0.80750133 |
| 39 | MP0005253_abnormal_eye_physiology | 0.76521515 |
| 40 | MP0003121_genomic_imprinting | 0.74570020 |
| 41 | MP0003866_abnormal_defecation | 0.74227831 |
| 42 | MP0002098_abnormal_vibrissa_morphology | 0.74217633 |
| 43 | MP0002693_abnormal_pancreas_physiology | 0.73928547 |
| 44 | MP0000609_abnormal_liver_physiology | 0.73826093 |
| 45 | MP0005164_abnormal_response_to | 0.73420089 |
| 46 | MP0000703_abnormal_thymus_morphology | 0.73285217 |
| 47 | MP0004019_abnormal_vitamin_homeostasis | 0.69941371 |
| 48 | MP0001915_intracranial_hemorrhage | 0.65454611 |
| 49 | MP0004947_skin_inflammation | 0.63193007 |
| 50 | MP0002136_abnormal_kidney_physiology | 0.63134072 |
| 51 | MP0003953_abnormal_hormone_level | 0.61963796 |
| 52 | MP0002998_abnormal_bone_remodeling | 0.61394305 |
| 53 | MP0008875_abnormal_xenobiotic_pharmacok | 0.60849285 |
| 54 | MP0002078_abnormal_glucose_homeostasis | 0.60056862 |
| 55 | MP0001851_eye_inflammation | 0.58331385 |
| 56 | MP0001533_abnormal_skeleton_physiology | 0.56880007 |
| 57 | MP0003195_calcinosis | 0.55041972 |
| 58 | MP0001845_abnormal_inflammatory_respons | 0.53901535 |
| 59 | MP0002722_abnormal_immune_system | 0.50643340 |
| 60 | MP0005551_abnormal_eye_electrophysiolog | 0.48760863 |
| 61 | MP0009642_abnormal_blood_homeostasis | 0.46021119 |
| 62 | MP0000920_abnormal_myelination | 0.43559413 |
| 63 | MP0005334_abnormal_fat_pad | 0.43129997 |
| 64 | MP0002429_abnormal_blood_cell | 0.41548044 |
| 65 | MP0002420_abnormal_adaptive_immunity | 0.40530110 |
| 66 | MP0002735_abnormal_chemical_nociception | 0.40481575 |
| 67 | MP0002419_abnormal_innate_immunity | 0.39719110 |
| 68 | MP0001819_abnormal_immune_cell | 0.39526796 |
| 69 | MP0002452_abnormal_antigen_presenting | 0.39268769 |
| 70 | MP0005423_abnormal_somatic_nervous | 0.38979205 |
| 71 | MP0000716_abnormal_immune_system | 0.38973686 |
| 72 | MP0002723_abnormal_immune_serum | 0.37751175 |
| 73 | MP0002822_catalepsy | 0.37111190 |
| 74 | MP0005000_abnormal_immune_tolerance | 0.36705595 |
| 75 | MP0002277_abnormal_respiratory_mucosa | 0.36644704 |
| 76 | MP0000477_abnormal_intestine_morphology | 0.36139078 |
| 77 | MP0002398_abnormal_bone_marrow | 0.35981571 |
| 78 | MP0001835_abnormal_antigen_presentation | 0.35216781 |
| 79 | MP0002882_abnormal_neuron_morphology | 0.34951087 |
| 80 | MP0000759_abnormal_skeletal_muscle | 0.34946314 |
| 81 | MP0001501_abnormal_sleep_pattern | 0.34855011 |
| 82 | MP0000598_abnormal_liver_morphology | 0.34556444 |
| 83 | MP0005365_abnormal_bile_salt | 0.32932892 |
| 84 | MP0002229_neurodegeneration | 0.30908351 |
| 85 | MP0003763_abnormal_thymus_physiology | 0.30303189 |
| 86 | MP0009931_abnormal_skin_appearance | 0.29320224 |
| 87 | MP0001986_abnormal_taste_sensitivity | 0.28727980 |
| 88 | MP0005390_skeleton_phenotype | 0.28546216 |
| 89 | MP0005395_other_phenotype | 0.27948381 |
| 90 | MP0001299_abnormal_eye_distance/ | 0.27638679 |
| 91 | MP0000689_abnormal_spleen_morphology | 0.27055116 |
| 92 | MP0006276_abnormal_autonomic_nervous | 0.26537232 |
| 93 | MP0004484_altered_response_of | 0.26398903 |
| 94 | MP0009053_abnormal_anal_canal | 0.25659480 |
| 95 | MP0005391_vision/eye_phenotype | 0.25251282 |
| 96 | MP0001175_abnormal_lung_morphology | 0.24267661 |
| 97 | MP0008004_abnormal_stomach_pH | 0.22659549 |
| 98 | MP0002066_abnormal_motor_capabilities/c | 0.22512334 |
| 99 | MP0006082_CNS_inflammation | 0.21954066 |
| 100 | MP0002161_abnormal_fertility/fecundity | 0.20991412 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 9.82436373 |
| 2 | Abnormality of renal resorption (HP:0011038) | 8.14173864 |
| 3 | Abnormality of dental color (HP:0011073) | 8.12430738 |
| 4 | Osteomalacia (HP:0002749) | 7.71819069 |
| 5 | Polyuria (HP:0000103) | 7.54837384 |
| 6 | Abnormality of the dental pulp (HP:0006479) | 7.46357971 |
| 7 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 7.08405977 |
| 8 | Abnormal urine output (HP:0012590) | 6.46949231 |
| 9 | Abnormality of renal excretion (HP:0011036) | 5.67747588 |
| 10 | Round ear (HP:0100830) | 5.45584938 |
| 11 | Chronic bronchitis (HP:0004469) | 5.01531634 |
| 12 | IgM deficiency (HP:0002850) | 4.49335818 |
| 13 | Autoimmune thrombocytopenia (HP:0001973) | 4.37811399 |
| 14 | Volvulus (HP:0002580) | 4.22751514 |
| 15 | Lip pit (HP:0100267) | 4.13032519 |
| 16 | Molar tooth sign on MRI (HP:0002419) | 4.02846950 |
| 17 | Abnormality of midbrain morphology (HP:0002418) | 4.02846950 |
| 18 | Nephrocalcinosis (HP:0000121) | 3.97449092 |
| 19 | Toxemia of pregnancy (HP:0100603) | 3.94714742 |
| 20 | Esophageal varix (HP:0002040) | 3.72146844 |
| 21 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.42753860 |
| 22 | Rhinitis (HP:0012384) | 3.35339750 |
| 23 | Lipoatrophy (HP:0100578) | 3.34498862 |
| 24 | Tachypnea (HP:0002789) | 3.26001020 |
| 25 | Depressed nasal tip (HP:0000437) | 3.24879197 |
| 26 | Drooling (HP:0002307) | 3.20190413 |
| 27 | Large earlobe (HP:0009748) | 3.15888000 |
| 28 | Intestinal fistula (HP:0100819) | 3.13965010 |
| 29 | Sparse lateral eyebrow (HP:0005338) | 3.12165497 |
| 30 | Excessive salivation (HP:0003781) | 3.07034189 |
| 31 | Hypoparathyroidism (HP:0000829) | 3.02655846 |
| 32 | Nephronophthisis (HP:0000090) | 2.94567601 |
| 33 | Panhypogammaglobulinemia (HP:0003139) | 2.94327644 |
| 34 | Hyperphosphaturia (HP:0003109) | 2.91750568 |
| 35 | Ureteral stenosis (HP:0000071) | 2.77567015 |
| 36 | Thick eyebrow (HP:0000574) | 2.74758758 |
| 37 | Petechiae (HP:0000967) | 2.57995259 |
| 38 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.57722345 |
| 39 | Ureteral obstruction (HP:0006000) | 2.57692496 |
| 40 | Hepatitis (HP:0012115) | 2.57630032 |
| 41 | Personality changes (HP:0000751) | 2.57361113 |
| 42 | Dilated cardiomyopathy (HP:0001644) | 2.49309080 |
| 43 | Recurrent cutaneous fungal infections (HP:0011370) | 2.47381143 |
| 44 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.47381143 |
| 45 | Abnormal urine phosphate concentration (HP:0012599) | 2.44931009 |
| 46 | Abnormality of urine glucose concentration (HP:0011016) | 2.36986091 |
| 47 | Glycosuria (HP:0003076) | 2.36986091 |
| 48 | Nephropathy (HP:0000112) | 2.31921076 |
| 49 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.29529354 |
| 50 | Gingival overgrowth (HP:0000212) | 2.28983287 |
| 51 | Striae distensae (HP:0001065) | 2.26177444 |
| 52 | Bronchitis (HP:0012387) | 2.25577524 |
| 53 | Agammaglobulinemia (HP:0004432) | 2.23936392 |
| 54 | Short 5th finger (HP:0009237) | 2.23205883 |
| 55 | Sudden cardiac death (HP:0001645) | 2.21209507 |
| 56 | Recurrent otitis media (HP:0000403) | 2.17238007 |
| 57 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 2.16647816 |
| 58 | Abnormality of the renal medulla (HP:0100957) | 2.15986063 |
| 59 | Hypercalciuria (HP:0002150) | 2.13580585 |
| 60 | Abnormality of the fingertips (HP:0001211) | 2.13136891 |
| 61 | Decreased muscle mass (HP:0003199) | 2.08161955 |
| 62 | Inability to walk (HP:0002540) | 2.07858267 |
| 63 | Periauricular skin pits (HP:0100277) | 2.07769116 |
| 64 | Preauricular pit (HP:0004467) | 2.07769116 |
| 65 | Colitis (HP:0002583) | 2.06004025 |
| 66 | Anal stenosis (HP:0002025) | 2.05677373 |
| 67 | Abnormality of salivation (HP:0100755) | 2.02100467 |
| 68 | Overgrowth (HP:0001548) | 11.9687064 |
| 69 | Amelogenesis imperfecta (HP:0000705) | 11.6292034 |
| 70 | Renal tubular dysfunction (HP:0000124) | 1.96169819 |
| 71 | Ectopic kidney (HP:0000086) | 1.94583434 |
| 72 | Chorioretinal coloboma (HP:0000567) | 1.91683337 |
| 73 | Prominent supraorbital ridges (HP:0000336) | 1.89587487 |
| 74 | Chondrocalcinosis (HP:0000934) | 1.88990805 |
| 75 | Delayed eruption of teeth (HP:0000684) | 1.85587255 |
| 76 | Abnormality of Sharpey fibers (HP:0100685) | 1.84155825 |
| 77 | Stage 5 chronic kidney disease (HP:0003774) | 1.78414532 |
| 78 | Preauricular skin tag (HP:0000384) | 1.78368783 |
| 79 | Truncal ataxia (HP:0002078) | 1.71899407 |
| 80 | Small hand (HP:0200055) | 1.69369897 |
| 81 | Abnormality of small intestinal villus morphology (HP:0011472) | 1.64127092 |
| 82 | Villous atrophy (HP:0011473) | 1.64127092 |
| 83 | Limited elbow extension (HP:0001377) | 1.63741407 |
| 84 | Polyneuropathy (HP:0001271) | 1.62292577 |
| 85 | Oculomotor apraxia (HP:0000657) | 1.59878865 |
| 86 | Bronchiectasis (HP:0002110) | 1.56431950 |
| 87 | Palmoplantar keratoderma (HP:0000982) | 1.55847367 |
| 88 | Ectropion (HP:0000656) | 1.55057756 |
| 89 | Autoimmune hemolytic anemia (HP:0001890) | 1.51169000 |
| 90 | Torticollis (HP:0000473) | 1.50211186 |
| 91 | Prenatal maternal abnormality (HP:0002686) | 1.47840143 |
| 92 | Skin tags (HP:0010609) | 1.47529972 |
| 93 | Blepharitis (HP:0000498) | 1.44716916 |
| 94 | Highly arched eyebrow (HP:0002553) | 1.44176538 |
| 95 | Skin pits (HP:0100276) | 1.38934687 |
| 96 | Mask-like facies (HP:0000298) | 1.37373184 |
| 97 | Inflammation of the large intestine (HP:0002037) | 1.32989835 |
| 98 | Proximal placement of thumb (HP:0009623) | 1.31930981 |
| 99 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.29703794 |
| 100 | Encephalitis (HP:0002383) | 1.26791716 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 5.95913423 |
| 2 | BLK | 4.22761320 |
| 3 | STK3 | 4.04245730 |
| 4 | RIPK4 | 3.04538607 |
| 5 | CDC42BPA | 2.07146158 |
| 6 | NTRK2 | 13.9686545 |
| 7 | BMPR2 | 1.93953022 |
| 8 | HIPK2 | 1.14615478 |
| 9 | INSRR | 1.13711049 |
| 10 | FGFR1 | 1.10324625 |
| 11 | TXK | 0.81989260 |
| 12 | PRKCQ | 0.77720023 |
| 13 | ROCK2 | 0.74787506 |
| 14 | SYK | 0.71892291 |
| 15 | MAPK15 | 0.67242809 |
| 16 | SRC | 0.64370938 |
| 17 | OBSCN | 0.63975669 |
| 18 | KDR | 0.62183529 |
| 19 | SRPK1 | 0.58630003 |
| 20 | MUSK | 0.56498213 |
| 21 | ROCK1 | 0.54936265 |
| 22 | MAP4K2 | 0.53018502 |
| 23 | PRKAA1 | 0.52725990 |
| 24 | PRKACG | 0.47505260 |
| 25 | ITK | 0.46687882 |
| 26 | GRK7 | 0.44771217 |
| 27 | GRK1 | 0.44306787 |
| 28 | WNK3 | 0.44018297 |
| 29 | TIE1 | 0.41301649 |
| 30 | PRKACA | 0.40359730 |
| 31 | ADRBK2 | 0.39929113 |
| 32 | ABL1 | 0.39655920 |
| 33 | PRKACB | 0.38426373 |
| 34 | CAMK2A | 0.35563897 |
| 35 | TNK2 | 0.32709542 |
| 36 | PIK3CG | 0.32179859 |
| 37 | MAP2K7 | 0.30916467 |
| 38 | LYN | 0.30878157 |
| 39 | ERBB4 | 0.30795634 |
| 40 | WNK4 | 0.29463310 |
| 41 | PLK4 | 0.28076211 |
| 42 | AKT3 | 0.27849794 |
| 43 | BUB1 | 0.26211208 |
| 44 | PLK1 | 0.26136888 |
| 45 | PRKCA | 0.25536157 |
| 46 | MAPK14 | 0.24072447 |
| 47 | KIT | 0.23454666 |
| 48 | GSK3B | 0.22619226 |
| 49 | EPHA4 | 0.21474170 |
| 50 | CHUK | 0.21263299 |
| 51 | FYN | 0.19963733 |
| 52 | CSNK1A1 | 0.19958399 |
| 53 | MATK | 0.19614723 |
| 54 | MAP2K6 | 0.19042700 |
| 55 | RPS6KA3 | 0.18626630 |
| 56 | PRKCB | 0.18572649 |
| 57 | BTK | 0.18382393 |
| 58 | TEC | 0.18349847 |
| 59 | LCK | 0.17294350 |
| 60 | CASK | 0.17009223 |
| 61 | OXSR1 | 0.16088485 |
| 62 | MST1R | 0.15932217 |
| 63 | DDR2 | 0.15500100 |
| 64 | PRKCD | 0.14622152 |
| 65 | TLK1 | 0.14534856 |
| 66 | IKBKE | 0.14508285 |
| 67 | TTN | 0.14487005 |
| 68 | CDK1 | 0.14433157 |
| 69 | MAPK9 | 0.14230479 |
| 70 | CSK | 0.14021476 |
| 71 | LMTK2 | 0.13351151 |
| 72 | GRK5 | 0.12339685 |
| 73 | EPHA2 | 0.12128453 |
| 74 | IGF1R | 0.11614217 |
| 75 | GRK6 | 0.10712275 |
| 76 | PHKG2 | 0.10601481 |
| 77 | PHKG1 | 0.10601481 |
| 78 | PIM2 | 0.10493823 |
| 79 | PRKCG | 0.10274530 |
| 80 | FLT3 | 0.09816249 |
| 81 | PRKDC | 0.09124451 |
| 82 | PKN1 | 0.08097798 |
| 83 | HCK | 0.07872456 |
| 84 | PINK1 | 0.07860028 |
| 85 | INSR | 0.07236542 |
| 86 | AKT1 | 0.06751711 |
| 87 | PIM1 | 0.06726177 |
| 88 | CDK3 | 0.06661947 |
| 89 | EGFR | 0.06236654 |
| 90 | ADRBK1 | 0.06154976 |
| 91 | IKBKB | 0.06149332 |
| 92 | PRKCE | 0.05745977 |
| 93 | CSF1R | 0.05726235 |
| 94 | CAMK2G | 0.05642506 |
| 95 | CAMK1 | 0.05630513 |
| 96 | WEE1 | 0.05244252 |
| 97 | FRK | 0.05173593 |
| 98 | TAOK2 | 0.05159091 |
| 99 | STK39 | 0.04663303 |
| 100 | VRK1 | 0.04344355 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Olfactory transduction_Homo sapiens_hsa04740 | 5.30379874 |
| 2 | Sulfur metabolism_Homo sapiens_hsa00920 | 3.73322443 |
| 3 | Sulfur relay system_Homo sapiens_hsa04122 | 3.71432911 |
| 4 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 3.31377384 |
| 5 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 3.16891450 |
| 6 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.93223914 |
| 7 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 2.83343027 |
| 8 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 2.67673848 |
| 9 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.55794581 |
| 10 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 2.39313903 |
| 11 | Bile secretion_Homo sapiens_hsa04976 | 2.34258626 |
| 12 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 2.21059793 |
| 13 | Pancreatic secretion_Homo sapiens_hsa04972 | 2.17218698 |
| 14 | Fat digestion and absorption_Homo sapiens_hsa04975 | 2.14497631 |
| 15 | Salivary secretion_Homo sapiens_hsa04970 | 2.09716845 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 2.07436404 |
| 17 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.03484139 |
| 18 | Cocaine addiction_Homo sapiens_hsa05030 | 1.95714929 |
| 19 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.90723701 |
| 20 | Circadian entrainment_Homo sapiens_hsa04713 | 1.82586066 |
| 21 | Insulin secretion_Homo sapiens_hsa04911 | 1.80361134 |
| 22 | Taste transduction_Homo sapiens_hsa04742 | 1.77357818 |
| 23 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.76035994 |
| 24 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.69367178 |
| 25 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.68694123 |
| 26 | GABAergic synapse_Homo sapiens_hsa04727 | 1.68007725 |
| 27 | Morphine addiction_Homo sapiens_hsa05032 | 1.66052871 |
| 28 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.63386507 |
| 29 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.62123712 |
| 30 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.58994358 |
| 31 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.52356787 |
| 32 | Gap junction_Homo sapiens_hsa04540 | 1.47248863 |
| 33 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.43623768 |
| 34 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.42687695 |
| 35 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.42220165 |
| 36 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.33394830 |
| 37 | Melanogenesis_Homo sapiens_hsa04916 | 1.29159298 |
| 38 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.26423190 |
| 39 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.17135268 |
| 40 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.15762432 |
| 41 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.15739579 |
| 42 | Platelet activation_Homo sapiens_hsa04611 | 1.14665843 |
| 43 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.14255705 |
| 44 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.06837781 |
| 45 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.06329952 |
| 46 | Circadian rhythm_Homo sapiens_hsa04710 | 0.97695827 |
| 47 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.84357266 |
| 48 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.80475555 |
| 49 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.76539038 |
| 50 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.75525802 |
| 51 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.73079372 |
| 52 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.72831296 |
| 53 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.66776105 |
| 54 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.63956841 |
| 55 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.59153924 |
| 56 | RNA degradation_Homo sapiens_hsa03018 | 0.54524500 |
| 57 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.49032550 |
| 58 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.48314445 |
| 59 | Parkinsons disease_Homo sapiens_hsa05012 | 0.43396372 |
| 60 | Alcoholism_Homo sapiens_hsa05034 | 0.39105738 |
| 61 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.35621392 |
| 62 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.33463669 |
| 63 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.33289514 |
| 64 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.32802083 |
| 65 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.32164654 |
| 66 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.31528842 |
| 67 | Prion diseases_Homo sapiens_hsa05020 | 0.31308482 |
| 68 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.29132759 |
| 69 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.27650861 |
| 70 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.25511114 |
| 71 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.25154995 |
| 72 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.22317407 |
| 73 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.21414134 |
| 74 | Purine metabolism_Homo sapiens_hsa00230 | 0.21392148 |
| 75 | Retinol metabolism_Homo sapiens_hsa00830 | 0.20155168 |
| 76 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.18574110 |
| 77 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.17534595 |
| 78 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.17420938 |
| 79 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.14838414 |
| 80 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.13731582 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.12526202 |
| 82 | Tuberculosis_Homo sapiens_hsa05152 | 0.12351318 |
| 83 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.12255216 |
| 84 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.12023079 |
| 85 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.11975323 |
| 86 | HTLV-I infection_Homo sapiens_hsa05166 | 0.11584152 |
| 87 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.11189440 |
| 88 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.11157044 |
| 89 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.10891191 |
| 90 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.10840619 |
| 91 | Phagosome_Homo sapiens_hsa04145 | 0.10785408 |
| 92 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.10737712 |
| 93 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.10334437 |
| 94 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.09842724 |
| 95 | Leishmaniasis_Homo sapiens_hsa05140 | 0.09773105 |
| 96 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.08368905 |
| 97 | Allograft rejection_Homo sapiens_hsa05330 | 0.06071995 |
| 98 | Nicotine addiction_Homo sapiens_hsa05033 | 0.05995613 |
| 99 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.05972179 |
| 100 | Asthma_Homo sapiens_hsa05310 | 0.04159534 |

