OR7E31P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 2 cell differentiation (GO:0045628)9.96706542
2activation of protein kinase A activity (GO:0034199)9.91130773
3positive regulation of RNA splicing (GO:0033120)9.55164228
4seminiferous tubule development (GO:0072520)9.51467918
5negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.10234491
6cAMP biosynthetic process (GO:0006171)8.68740073
7detection of chemical stimulus involved in sensory perception (GO:0050907)8.43630949
8negative regulation of alpha-beta T cell differentiation (GO:0046639)8.28088741
9enteric nervous system development (GO:0048484)7.84701940
10regulation of protein sumoylation (GO:0033233)7.53239629
11righting reflex (GO:0060013)7.00604820
12positive regulation of mitochondrial fission (GO:0090141)6.96982202
13synaptic transmission, dopaminergic (GO:0001963)6.96368560
14dendritic spine morphogenesis (GO:0060997)6.85270552
15heterotypic cell-cell adhesion (GO:0034113)6.57476140
16positive regulation of T-helper 1 type immune response (GO:0002827)6.31929464
17arachidonic acid secretion (GO:0050482)6.11781886
18icosanoid secretion (GO:0032309)6.11781886
19detection of chemical stimulus (GO:0009593)6.05939222
20endothelial cell differentiation (GO:0045446)5.90406873
21hepatocyte apoptotic process (GO:0097284)5.89171815
22positive regulation of T-helper cell differentiation (GO:0045624)5.72137578
23phosphatidylinositol acyl-chain remodeling (GO:0036149)5.44865449
24drug transmembrane transport (GO:0006855)5.32163116
25regulation of mitochondrial fission (GO:0090140)5.13060067
26phosphatidylserine acyl-chain remodeling (GO:0036150)5.09037566
27fatty acid derivative transport (GO:1901571)5.06217496
28icosanoid transport (GO:0071715)5.06217496
29negative regulation of alpha-beta T cell activation (GO:0046636)5.03559332
30phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.93227377
31neuronal ion channel clustering (GO:0045161)4.89249898
32neural tube formation (GO:0001841)4.76840383
33chemosensory behavior (GO:0007635)4.71708749
34embryonic digestive tract morphogenesis (GO:0048557)4.60051644
35hyaluronan catabolic process (GO:0030214)4.58701919
36regulation of T-helper 1 type immune response (GO:0002825)4.56376478
37cilium or flagellum-dependent cell motility (GO:0001539)4.51264701
38nephron epithelium morphogenesis (GO:0072088)4.45673962
39nephron tubule morphogenesis (GO:0072078)4.45673962
40positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.38095817
41ATP hydrolysis coupled proton transport (GO:0015991)4.34110068
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.34110068
43cyclic purine nucleotide metabolic process (GO:0052652)4.31197572
44attachment of spindle microtubules to kinetochore (GO:0008608)4.28220362
45retina layer formation (GO:0010842)4.26727100
46vocalization behavior (GO:0071625)4.24169022
47regulation of T-helper cell differentiation (GO:0045622)4.18142558
48cyclic nucleotide biosynthetic process (GO:0009190)4.17172079
49negative regulation of actin filament bundle assembly (GO:0032232)4.16439052
50positive regulation of membrane potential (GO:0045838)4.15812835
51regulation of type 2 immune response (GO:0002828)4.12013698
52regulation of cAMP-mediated signaling (GO:0043949)4.11909215
53response to dietary excess (GO:0002021)4.10201226
54cellular response to glucagon stimulus (GO:0071377)4.09703451
55water transport (GO:0006833)3.99947472
56mitochondrial fusion (GO:0008053)3.91508978
57cAMP metabolic process (GO:0046058)3.91183176
58dendritic spine organization (GO:0097061)3.89753135
59protein localization to synapse (GO:0035418)3.88864443
60negative regulation of T cell differentiation (GO:0045581)3.88369637
61positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.86862019
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.84517938
63monoamine transport (GO:0015844)3.75181369
64cellular zinc ion homeostasis (GO:0006882)3.72816786
65drug transport (GO:0015893)3.69258079
66cytoskeletal anchoring at plasma membrane (GO:0007016)3.67307502
67phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.59907747
68fluid transport (GO:0042044)3.58575944
69leukotriene biosynthetic process (GO:0019370)3.53106625
70positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.48088602
71sulfur amino acid catabolic process (GO:0000098)3.43647397
72positive regulation of protein targeting to membrane (GO:0090314)3.42176318
73cellular response to ATP (GO:0071318)3.38224653
74pre-miRNA processing (GO:0031054)3.38155273
75sequestering of metal ion (GO:0051238)3.37909646
76neuromuscular process controlling posture (GO:0050884)3.37541779
77left/right axis specification (GO:0070986)3.34079529
78negative regulation of homotypic cell-cell adhesion (GO:0034111)3.33232706
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.31357221
80positive regulation of alpha-beta T cell differentiation (GO:0046638)3.30974284
81renal tubule morphogenesis (GO:0061333)3.18471509
82negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.14768691
83negative regulation of astrocyte differentiation (GO:0048712)3.13708560
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13102072
85phosphatidylcholine acyl-chain remodeling (GO:0036151)3.11417589
86positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04900515
87prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.04417538
88positive regulation of steroid hormone secretion (GO:2000833)3.03933179
89adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.03202663
90reflex (GO:0060004)3.02413644
91response to glucagon (GO:0033762)3.02342414
92adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.01548732
93tooth mineralization (GO:0034505)14.2666729
94detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.5795999
95positive regulation of protein sumoylation (GO:0033235)11.9436650
96negative regulation of T-helper cell differentiation (GO:0045623)11.2831714
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.2831714
98protein K11-linked deubiquitination (GO:0035871)10.5113250
99regulation of T-helper 1 cell differentiation (GO:0045625)10.2010689
100negative regulation of type 2 immune response (GO:0002829)10.0173195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.79473480
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.38733438
3IGF1R_20145208_ChIP-Seq_DFB_Human4.70537981
4AR_21572438_ChIP-Seq_LNCaP_Human4.68606463
5VDR_22108803_ChIP-Seq_LS180_Human4.24290133
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.34048886
7TP53_16413492_ChIP-PET_HCT116_Human2.21073694
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04439579
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.4476931
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.95778240
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90984313
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86514862
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86514862
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83790196
15GATA1_19941826_ChIP-Seq_K562_Human1.72967866
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63572553
17DROSHA_22980978_ChIP-Seq_HELA_Human1.62436699
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60644532
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.57548308
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.57103771
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54507099
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47346774
23EGR1_19032775_ChIP-ChIP_M12_Human1.45204390
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.44942278
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41599212
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41210642
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40458745
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39695803
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.37776123
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36775984
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.33877097
32RXR_22108803_ChIP-Seq_LS180_Human1.26829660
33TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.26716860
34RNF2_27304074_Chip-Seq_NSC_Mouse1.26209506
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.22789324
36EZH2_22144423_ChIP-Seq_EOC_Human1.19887287
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.17468338
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17313517
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16244115
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15886068
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.14226571
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.13878790
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13067031
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12696112
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12369913
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11441768
47HNFA_21074721_ChIP-Seq_CACO-2_Human1.09318086
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.08790553
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08492115
50ER_23166858_ChIP-Seq_MCF-7_Human1.08379043
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05411815
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05304743
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05108369
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04346592
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03934939
56SOX2_18555785_Chip-Seq_ESCs_Mouse1.03765144
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.03687822
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03489016
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03412872
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.02988967
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02610437
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99129649
63DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98530957
64ARNT_22903824_ChIP-Seq_MCF-7_Human0.98454461
65SMAD4_21741376_ChIP-Seq_HESCs_Human0.97313040
66TBL1_22424771_ChIP-Seq_293T_Human0.96651100
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95200845
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94924393
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94836255
70CMYC_18555785_Chip-Seq_ESCs_Mouse0.94775101
71GBX2_23144817_ChIP-Seq_PC3_Human0.94500391
72PHF8_20622853_ChIP-Seq_HELA_Human0.92829991
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92509743
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90815291
75STAT3_23295773_ChIP-Seq_U87_Human0.90589580
76CJUN_26792858_Chip-Seq_BT549_Human0.88747061
77BCAT_22108803_ChIP-Seq_LS180_Human0.88529833
78ZNF274_21170338_ChIP-Seq_K562_Hela0.88454614
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87235823
80CTCF_27219007_Chip-Seq_Bcells_Human0.86865518
81PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.85259315
82SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84788284
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84239584
84EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83943383
85RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83943383
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83021444
87KLF4_18555785_Chip-Seq_ESCs_Mouse0.82807781
88REST_21632747_ChIP-Seq_MESCs_Mouse0.82699529
89NMYC_18555785_Chip-Seq_ESCs_Mouse0.82155937
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81696888
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.81592558
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81563373
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80158058
94NANOG_16518401_ChIP-PET_MESCs_Mouse0.80007411
95NANOG_20526341_ChIP-Seq_ESCs_Human0.77892000
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77131857
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77075076
98RING1B_27294783_Chip-Seq_ESCs_Mouse0.77000102
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.76701199
100CBP_20019798_ChIP-Seq_JUKART_Human0.76359792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.63913479
2MP0004130_abnormal_muscle_cell4.88780828
3MP0004264_abnormal_extraembryonic_tissu3.80124714
4MP0003252_abnormal_bile_duct3.63236078
5MP0002928_abnormal_bile_duct2.77335460
6MP0004133_heterotaxia2.73524605
7MP0006072_abnormal_retinal_apoptosis2.53880311
8MP0005408_hypopigmentation2.34038699
9MP0005448_abnormal_energy_balance2.25157038
10MP0002751_abnormal_autonomic_nervous2.24686598
11MP0003329_amyloid_beta_deposits2.14193447
12MP0001270_distended_abdomen2.05308401
13MP0005084_abnormal_gallbladder_morpholo12.5620463
14MP0004272_abnormal_basement_membrane1.97701861
15MP0003943_abnormal_hepatobiliary_system1.70209123
16MP0005220_abnormal_exocrine_pancreas1.58173780
17MP0005379_endocrine/exocrine_gland_phen1.57219850
18MP0005165_increased_susceptibility_to1.53456774
19MP0009764_decreased_sensitivity_to1.42894205
20MP0001958_emphysema1.42372510
21MP0000604_amyloidosis1.41853092
22MP0001529_abnormal_vocalization1.38063037
23MP0003718_maternal_effect1.25758160
24MP0001905_abnormal_dopamine_level1.15124091
25MP0005646_abnormal_pituitary_gland1.14184349
26MP0008569_lethality_at_weaning1.04369050
27MP0000465_gastrointestinal_hemorrhage1.01560705
28MP0000470_abnormal_stomach_morphology1.01162940
29MP0002572_abnormal_emotion/affect_behav1.00667828
30MP0003638_abnormal_response/metabolism_0.97517514
31MP0002909_abnormal_adrenal_gland0.93938301
32MP0001944_abnormal_pancreas_morphology0.93732073
33MP0002405_respiratory_system_inflammati0.85671317
34MP0001800_abnormal_humoral_immune0.84087894
35MP0000371_diluted_coat_color0.82348550
36MP0001790_abnormal_immune_system0.81142156
37MP0005387_immune_system_phenotype0.81142156
38MP0008469_abnormal_protein_level0.80750133
39MP0005253_abnormal_eye_physiology0.76521515
40MP0003121_genomic_imprinting0.74570020
41MP0003866_abnormal_defecation0.74227831
42MP0002098_abnormal_vibrissa_morphology0.74217633
43MP0002693_abnormal_pancreas_physiology0.73928547
44MP0000609_abnormal_liver_physiology0.73826093
45MP0005164_abnormal_response_to0.73420089
46MP0000703_abnormal_thymus_morphology0.73285217
47MP0004019_abnormal_vitamin_homeostasis0.69941371
48MP0001915_intracranial_hemorrhage0.65454611
49MP0004947_skin_inflammation0.63193007
50MP0002136_abnormal_kidney_physiology0.63134072
51MP0003953_abnormal_hormone_level0.61963796
52MP0002998_abnormal_bone_remodeling0.61394305
53MP0008875_abnormal_xenobiotic_pharmacok0.60849285
54MP0002078_abnormal_glucose_homeostasis0.60056862
55MP0001851_eye_inflammation0.58331385
56MP0001533_abnormal_skeleton_physiology0.56880007
57MP0003195_calcinosis0.55041972
58MP0001845_abnormal_inflammatory_respons0.53901535
59MP0002722_abnormal_immune_system0.50643340
60MP0005551_abnormal_eye_electrophysiolog0.48760863
61MP0009642_abnormal_blood_homeostasis0.46021119
62MP0000920_abnormal_myelination0.43559413
63MP0005334_abnormal_fat_pad0.43129997
64MP0002429_abnormal_blood_cell0.41548044
65MP0002420_abnormal_adaptive_immunity0.40530110
66MP0002735_abnormal_chemical_nociception0.40481575
67MP0002419_abnormal_innate_immunity0.39719110
68MP0001819_abnormal_immune_cell0.39526796
69MP0002452_abnormal_antigen_presenting0.39268769
70MP0005423_abnormal_somatic_nervous0.38979205
71MP0000716_abnormal_immune_system0.38973686
72MP0002723_abnormal_immune_serum0.37751175
73MP0002822_catalepsy0.37111190
74MP0005000_abnormal_immune_tolerance0.36705595
75MP0002277_abnormal_respiratory_mucosa0.36644704
76MP0000477_abnormal_intestine_morphology0.36139078
77MP0002398_abnormal_bone_marrow0.35981571
78MP0001835_abnormal_antigen_presentation0.35216781
79MP0002882_abnormal_neuron_morphology0.34951087
80MP0000759_abnormal_skeletal_muscle0.34946314
81MP0001501_abnormal_sleep_pattern0.34855011
82MP0000598_abnormal_liver_morphology0.34556444
83MP0005365_abnormal_bile_salt0.32932892
84MP0002229_neurodegeneration0.30908351
85MP0003763_abnormal_thymus_physiology0.30303189
86MP0009931_abnormal_skin_appearance0.29320224
87MP0001986_abnormal_taste_sensitivity0.28727980
88MP0005390_skeleton_phenotype0.28546216
89MP0005395_other_phenotype0.27948381
90MP0001299_abnormal_eye_distance/0.27638679
91MP0000689_abnormal_spleen_morphology0.27055116
92MP0006276_abnormal_autonomic_nervous0.26537232
93MP0004484_altered_response_of0.26398903
94MP0009053_abnormal_anal_canal0.25659480
95MP0005391_vision/eye_phenotype0.25251282
96MP0001175_abnormal_lung_morphology0.24267661
97MP0008004_abnormal_stomach_pH0.22659549
98MP0002066_abnormal_motor_capabilities/c0.22512334
99MP0006082_CNS_inflammation0.21954066
100MP0002161_abnormal_fertility/fecundity0.20991412

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.82436373
2Abnormality of renal resorption (HP:0011038)8.14173864
3Abnormality of dental color (HP:0011073)8.12430738
4Osteomalacia (HP:0002749)7.71819069
5Polyuria (HP:0000103)7.54837384
6Abnormality of the dental pulp (HP:0006479)7.46357971
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.08405977
8Abnormal urine output (HP:0012590)6.46949231
9Abnormality of renal excretion (HP:0011036)5.67747588
10Round ear (HP:0100830)5.45584938
11Chronic bronchitis (HP:0004469)5.01531634
12IgM deficiency (HP:0002850)4.49335818
13Autoimmune thrombocytopenia (HP:0001973)4.37811399
14Volvulus (HP:0002580)4.22751514
15Lip pit (HP:0100267)4.13032519
16Molar tooth sign on MRI (HP:0002419)4.02846950
17Abnormality of midbrain morphology (HP:0002418)4.02846950
18Nephrocalcinosis (HP:0000121)3.97449092
19Toxemia of pregnancy (HP:0100603)3.94714742
20Esophageal varix (HP:0002040)3.72146844
21Abnormal respiratory motile cilium physiology (HP:0012261)3.42753860
22Rhinitis (HP:0012384)3.35339750
23Lipoatrophy (HP:0100578)3.34498862
24Tachypnea (HP:0002789)3.26001020
25Depressed nasal tip (HP:0000437)3.24879197
26Drooling (HP:0002307)3.20190413
27Large earlobe (HP:0009748)3.15888000
28Intestinal fistula (HP:0100819)3.13965010
29Sparse lateral eyebrow (HP:0005338)3.12165497
30Excessive salivation (HP:0003781)3.07034189
31Hypoparathyroidism (HP:0000829)3.02655846
32Nephronophthisis (HP:0000090)2.94567601
33Panhypogammaglobulinemia (HP:0003139)2.94327644
34Hyperphosphaturia (HP:0003109)2.91750568
35Ureteral stenosis (HP:0000071)2.77567015
36Thick eyebrow (HP:0000574)2.74758758
37Petechiae (HP:0000967)2.57995259
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.57722345
39Ureteral obstruction (HP:0006000)2.57692496
40Hepatitis (HP:0012115)2.57630032
41Personality changes (HP:0000751)2.57361113
42Dilated cardiomyopathy (HP:0001644)2.49309080
43Recurrent cutaneous fungal infections (HP:0011370)2.47381143
44Chronic mucocutaneous candidiasis (HP:0002728)2.47381143
45Abnormal urine phosphate concentration (HP:0012599)2.44931009
46Abnormality of urine glucose concentration (HP:0011016)2.36986091
47Glycosuria (HP:0003076)2.36986091
48Nephropathy (HP:0000112)2.31921076
49Abnormality of transition element cation homeostasis (HP:0011030)2.29529354
50Gingival overgrowth (HP:0000212)2.28983287
51Striae distensae (HP:0001065)2.26177444
52Bronchitis (HP:0012387)2.25577524
53Agammaglobulinemia (HP:0004432)2.23936392
54Short 5th finger (HP:0009237)2.23205883
55Sudden cardiac death (HP:0001645)2.21209507
56Recurrent otitis media (HP:0000403)2.17238007
57Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.16647816
58Abnormality of the renal medulla (HP:0100957)2.15986063
59Hypercalciuria (HP:0002150)2.13580585
60Abnormality of the fingertips (HP:0001211)2.13136891
61Decreased muscle mass (HP:0003199)2.08161955
62Inability to walk (HP:0002540)2.07858267
63Periauricular skin pits (HP:0100277)2.07769116
64Preauricular pit (HP:0004467)2.07769116
65Colitis (HP:0002583)2.06004025
66Anal stenosis (HP:0002025)2.05677373
67Abnormality of salivation (HP:0100755)2.02100467
68Overgrowth (HP:0001548)11.9687064
69Amelogenesis imperfecta (HP:0000705)11.6292034
70Renal tubular dysfunction (HP:0000124)1.96169819
71Ectopic kidney (HP:0000086)1.94583434
72Chorioretinal coloboma (HP:0000567)1.91683337
73Prominent supraorbital ridges (HP:0000336)1.89587487
74Chondrocalcinosis (HP:0000934)1.88990805
75Delayed eruption of teeth (HP:0000684)1.85587255
76Abnormality of Sharpey fibers (HP:0100685)1.84155825
77Stage 5 chronic kidney disease (HP:0003774)1.78414532
78Preauricular skin tag (HP:0000384)1.78368783
79Truncal ataxia (HP:0002078)1.71899407
80Small hand (HP:0200055)1.69369897
81Abnormality of small intestinal villus morphology (HP:0011472)1.64127092
82Villous atrophy (HP:0011473)1.64127092
83Limited elbow extension (HP:0001377)1.63741407
84Polyneuropathy (HP:0001271)1.62292577
85Oculomotor apraxia (HP:0000657)1.59878865
86Bronchiectasis (HP:0002110)1.56431950
87Palmoplantar keratoderma (HP:0000982)1.55847367
88Ectropion (HP:0000656)1.55057756
89Autoimmune hemolytic anemia (HP:0001890)1.51169000
90Torticollis (HP:0000473)1.50211186
91Prenatal maternal abnormality (HP:0002686)1.47840143
92Skin tags (HP:0010609)1.47529972
93Blepharitis (HP:0000498)1.44716916
94Highly arched eyebrow (HP:0002553)1.44176538
95Skin pits (HP:0100276)1.38934687
96Mask-like facies (HP:0000298)1.37373184
97Inflammation of the large intestine (HP:0002037)1.32989835
98Proximal placement of thumb (HP:0009623)1.31930981
99Aplasia/Hypoplasia of the earlobes (HP:0009906)1.29703794
100Encephalitis (HP:0002383)1.26791716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.95913423
2BLK4.22761320
3STK34.04245730
4RIPK43.04538607
5CDC42BPA2.07146158
6NTRK213.9686545
7BMPR21.93953022
8HIPK21.14615478
9INSRR1.13711049
10FGFR11.10324625
11TXK0.81989260
12PRKCQ0.77720023
13ROCK20.74787506
14SYK0.71892291
15MAPK150.67242809
16SRC0.64370938
17OBSCN0.63975669
18KDR0.62183529
19SRPK10.58630003
20MUSK0.56498213
21ROCK10.54936265
22MAP4K20.53018502
23PRKAA10.52725990
24PRKACG0.47505260
25ITK0.46687882
26GRK70.44771217
27GRK10.44306787
28WNK30.44018297
29TIE10.41301649
30PRKACA0.40359730
31ADRBK20.39929113
32ABL10.39655920
33PRKACB0.38426373
34CAMK2A0.35563897
35TNK20.32709542
36PIK3CG0.32179859
37MAP2K70.30916467
38LYN0.30878157
39ERBB40.30795634
40WNK40.29463310
41PLK40.28076211
42AKT30.27849794
43BUB10.26211208
44PLK10.26136888
45PRKCA0.25536157
46MAPK140.24072447
47KIT0.23454666
48GSK3B0.22619226
49EPHA40.21474170
50CHUK0.21263299
51FYN0.19963733
52CSNK1A10.19958399
53MATK0.19614723
54MAP2K60.19042700
55RPS6KA30.18626630
56PRKCB0.18572649
57BTK0.18382393
58TEC0.18349847
59LCK0.17294350
60CASK0.17009223
61OXSR10.16088485
62MST1R0.15932217
63DDR20.15500100
64PRKCD0.14622152
65TLK10.14534856
66IKBKE0.14508285
67TTN0.14487005
68CDK10.14433157
69MAPK90.14230479
70CSK0.14021476
71LMTK20.13351151
72GRK50.12339685
73EPHA20.12128453
74IGF1R0.11614217
75GRK60.10712275
76PHKG20.10601481
77PHKG10.10601481
78PIM20.10493823
79PRKCG0.10274530
80FLT30.09816249
81PRKDC0.09124451
82PKN10.08097798
83HCK0.07872456
84PINK10.07860028
85INSR0.07236542
86AKT10.06751711
87PIM10.06726177
88CDK30.06661947
89EGFR0.06236654
90ADRBK10.06154976
91IKBKB0.06149332
92PRKCE0.05745977
93CSF1R0.05726235
94CAMK2G0.05642506
95CAMK10.05630513
96WEE10.05244252
97FRK0.05173593
98TAOK20.05159091
99STK390.04663303
100VRK10.04344355

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.30379874
2Sulfur metabolism_Homo sapiens_hsa009203.73322443
3Sulfur relay system_Homo sapiens_hsa041223.71432911
4Ovarian steroidogenesis_Homo sapiens_hsa049133.31377384
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.16891450
6Linoleic acid metabolism_Homo sapiens_hsa005912.93223914
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.83343027
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.67673848
9Collecting duct acid secretion_Homo sapiens_hsa049662.55794581
10Vibrio cholerae infection_Homo sapiens_hsa051102.39313903
11Bile secretion_Homo sapiens_hsa049762.34258626
12Thyroid hormone synthesis_Homo sapiens_hsa049182.21059793
13Pancreatic secretion_Homo sapiens_hsa049722.17218698
14Fat digestion and absorption_Homo sapiens_hsa049752.14497631
15Salivary secretion_Homo sapiens_hsa049702.09716845
16Gastric acid secretion_Homo sapiens_hsa049712.07436404
17Synaptic vesicle cycle_Homo sapiens_hsa047212.03484139
18Cocaine addiction_Homo sapiens_hsa050301.95714929
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90723701
20Circadian entrainment_Homo sapiens_hsa047131.82586066
21Insulin secretion_Homo sapiens_hsa049111.80361134
22Taste transduction_Homo sapiens_hsa047421.77357818
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.76035994
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69367178
25Glutamatergic synapse_Homo sapiens_hsa047241.68694123
26GABAergic synapse_Homo sapiens_hsa047271.68007725
27Morphine addiction_Homo sapiens_hsa050321.66052871
28Dilated cardiomyopathy_Homo sapiens_hsa054141.63386507
29Ether lipid metabolism_Homo sapiens_hsa005651.62123712
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.58994358
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52356787
32Gap junction_Homo sapiens_hsa045401.47248863
33Amphetamine addiction_Homo sapiens_hsa050311.43623768
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42687695
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42220165
36GnRH signaling pathway_Homo sapiens_hsa049121.33394830
37Melanogenesis_Homo sapiens_hsa049161.29159298
38Arachidonic acid metabolism_Homo sapiens_hsa005901.26423190
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17135268
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15762432
41Oxytocin signaling pathway_Homo sapiens_hsa049211.15739579
42Platelet activation_Homo sapiens_hsa046111.14665843
43Cholinergic synapse_Homo sapiens_hsa047251.14255705
44Estrogen signaling pathway_Homo sapiens_hsa049151.06837781
45Calcium signaling pathway_Homo sapiens_hsa040201.06329952
46Circadian rhythm_Homo sapiens_hsa047100.97695827
47Rheumatoid arthritis_Homo sapiens_hsa053230.84357266
48Dorso-ventral axis formation_Homo sapiens_hsa043200.80475555
49Chemokine signaling pathway_Homo sapiens_hsa040620.76539038
50Serotonergic synapse_Homo sapiens_hsa047260.75525802
51Oocyte meiosis_Homo sapiens_hsa041140.73079372
52Pyruvate metabolism_Homo sapiens_hsa006200.72831296
53ECM-receptor interaction_Homo sapiens_hsa045120.66776105
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63956841
55Primary immunodeficiency_Homo sapiens_hsa053400.59153924
56RNA degradation_Homo sapiens_hsa030180.54524500
57cAMP signaling pathway_Homo sapiens_hsa040240.49032550
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48314445
59Parkinsons disease_Homo sapiens_hsa050120.43396372
60Alcoholism_Homo sapiens_hsa050340.39105738
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35621392
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.33463669
63Staphylococcus aureus infection_Homo sapiens_hsa051500.33289514
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32802083
65Dopaminergic synapse_Homo sapiens_hsa047280.32164654
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.31528842
67Prion diseases_Homo sapiens_hsa050200.31308482
68Oxidative phosphorylation_Homo sapiens_hsa001900.29132759
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27650861
70Rap1 signaling pathway_Homo sapiens_hsa040150.25511114
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.25154995
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.22317407
73Type I diabetes mellitus_Homo sapiens_hsa049400.21414134
74Purine metabolism_Homo sapiens_hsa002300.21392148
75Retinol metabolism_Homo sapiens_hsa008300.20155168
76Hedgehog signaling pathway_Homo sapiens_hsa043400.18574110
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.17534595
78Graft-versus-host disease_Homo sapiens_hsa053320.17420938
79African trypanosomiasis_Homo sapiens_hsa051430.14838414
80Antigen processing and presentation_Homo sapiens_hsa046120.13731582
81Glucagon signaling pathway_Homo sapiens_hsa049220.12526202
82Tuberculosis_Homo sapiens_hsa051520.12351318
83Ras signaling pathway_Homo sapiens_hsa040140.12255216
84Hematopoietic cell lineage_Homo sapiens_hsa046400.12023079
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.11975323
86HTLV-I infection_Homo sapiens_hsa051660.11584152
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.11189440
88Systemic lupus erythematosus_Homo sapiens_hsa053220.11157044
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10891191
90Chemical carcinogenesis_Homo sapiens_hsa052040.10840619
91Phagosome_Homo sapiens_hsa041450.10785408
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10737712
93Autoimmune thyroid disease_Homo sapiens_hsa053200.10334437
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09842724
95Leishmaniasis_Homo sapiens_hsa051400.09773105
96Caffeine metabolism_Homo sapiens_hsa002320.08368905
97Allograft rejection_Homo sapiens_hsa053300.06071995
98Nicotine addiction_Homo sapiens_hsa050330.05995613
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05972179
100Asthma_Homo sapiens_hsa053100.04159534

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