OR7E33P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1female gonad development (GO:0008585)9.19215792
2regulation of telomere maintenance via telomerase (GO:0032210)8.20713356
3inner mitochondrial membrane organization (GO:0007007)7.38965885
4cranial suture morphogenesis (GO:0060363)7.21849681
5male meiosis (GO:0007140)7.18746199
6stress granule assembly (GO:0034063)6.75648986
7central nervous system neuron axonogenesis (GO:0021955)6.75446807
8negative regulation of telomere maintenance (GO:0032205)6.57634066
9cellular response to hepatocyte growth factor stimulus (GO:0035729)6.34657856
10response to hepatocyte growth factor (GO:0035728)6.34657856
11thyroid hormone generation (GO:0006590)6.32308745
12negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)6.28052743
13peptidyl-lysine dimethylation (GO:0018027)6.11828937
14negative regulation of glycoprotein biosynthetic process (GO:0010561)6.11433726
15regulation of protein glycosylation (GO:0060049)6.02976618
16positive regulation of keratinocyte differentiation (GO:0045618)6.00407565
17regulation of G0 to G1 transition (GO:0070316)5.98672625
18ventricular trabecula myocardium morphogenesis (GO:0003222)5.89379986
19DNA strand renaturation (GO:0000733)5.67489510
20apoptotic DNA fragmentation (GO:0006309)5.62856611
21lipid translocation (GO:0034204)5.59754175
22phospholipid translocation (GO:0045332)5.59754175
23centrosome duplication (GO:0051298)5.57585671
24somatic diversification of immune receptors via somatic mutation (GO:0002566)5.49236658
25somatic hypermutation of immunoglobulin genes (GO:0016446)5.49236658
26thyroid hormone metabolic process (GO:0042403)5.15280412
27regulation of natural killer cell mediated immunity (GO:0002715)5.09382859
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.09382859
29intermediate filament cytoskeleton organization (GO:0045104)4.92674688
30negative regulation of keratinocyte proliferation (GO:0010839)4.92046168
31intermediate filament-based process (GO:0045103)4.79819996
32heart trabecula morphogenesis (GO:0061384)4.75165474
33mitotic G2 DNA damage checkpoint (GO:0007095)4.74592246
34negative regulation of glycoprotein metabolic process (GO:1903019)4.66540673
35regulation of sister chromatid cohesion (GO:0007063)4.64579711
36craniofacial suture morphogenesis (GO:0097094)4.54427363
37vitamin transmembrane transport (GO:0035461)4.46019249
38negative regulation of fatty acid biosynthetic process (GO:0045717)4.45184080
39maintenance of protein location in nucleus (GO:0051457)4.36936955
40cellular response to thyroid hormone stimulus (GO:0097067)4.36229097
41positive regulation of protein import into nucleus, translocation (GO:0033160)4.35706624
42galactose metabolic process (GO:0006012)4.28769248
43positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.23629990
44trabecula morphogenesis (GO:0061383)4.21680328
45embryonic heart tube development (GO:0035050)4.17778195
46negative regulation of protein tyrosine kinase activity (GO:0061099)4.16276042
47viral protein processing (GO:0019082)4.14426665
48positive regulation of epidermal cell differentiation (GO:0045606)4.07332316
49SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)4.04920182
50regulation of histone phosphorylation (GO:0033127)3.99305072
51negative regulation of receptor activity (GO:2000272)3.97938532
52mitotic G2/M transition checkpoint (GO:0044818)3.91555172
53protein-cofactor linkage (GO:0018065)3.88323728
54hydrogen peroxide biosynthetic process (GO:0050665)3.78340208
55androgen biosynthetic process (GO:0006702)3.73893995
56pyrimidine-containing compound transmembrane transport (GO:0072531)3.71378836
57negative regulation of translation, ncRNA-mediated (GO:0040033)3.69191838
58regulation of translation, ncRNA-mediated (GO:0045974)3.69191838
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.69191838
60outer ear morphogenesis (GO:0042473)3.67369966
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65704815
62intracellular protein transmembrane import (GO:0044743)3.63629753
63natural killer cell activation (GO:0030101)3.58086736
64mast cell activation (GO:0045576)3.52043001
65regulation of interferon-beta biosynthetic process (GO:0045357)3.51503701
66regulation of telomere maintenance (GO:0032204)3.48341840
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.47092941
68positive regulation of fatty acid beta-oxidation (GO:0032000)3.46253150
69reactive oxygen species biosynthetic process (GO:1903409)3.44555646
70middle ear morphogenesis (GO:0042474)3.41495022
71RNA destabilization (GO:0050779)3.41469330
72positive regulation of transcription regulatory region DNA binding (GO:2000679)3.41096863
73mRNA transcription from RNA polymerase II promoter (GO:0042789)3.40557522
74regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.28546636
75regulation of membrane lipid distribution (GO:0097035)3.28106990
76replication fork processing (GO:0031297)3.27334779
77cell migration involved in heart development (GO:0060973)3.25010645
78vitamin transport (GO:0051180)3.24112278
79megakaryocyte development (GO:0035855)3.19374233
80peptidyl-lysine methylation (GO:0018022)3.17422051
81mammary gland epithelial cell proliferation (GO:0033598)3.16843064
82endocardial cushion morphogenesis (GO:0003203)3.16333410
83regulation of keratinocyte proliferation (GO:0010837)3.14720243
84regulation of transcription from RNA polymerase I promoter (GO:0006356)3.13399082
85response to thyroid hormone (GO:0097066)2.94119611
86regulation of voltage-gated calcium channel activity (GO:1901385)2.87082885
87acrosome assembly (GO:0001675)2.86749350
88positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.82466825
89positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81266131
90regulation of mammary gland epithelial cell proliferation (GO:0033599)2.79658862
91regulation of leukocyte mediated cytotoxicity (GO:0001910)2.76535934
92embryonic hindlimb morphogenesis (GO:0035116)2.75721849
93superoxide anion generation (GO:0042554)2.75161331
94regulation of keratinocyte differentiation (GO:0045616)2.73103746
95neurofilament cytoskeleton organization (GO:0060052)18.2345407
96regulation of DNA methylation (GO:0044030)14.7965204
97ectoderm development (GO:0007398)11.7002238
98glyoxylate metabolic process (GO:0046487)11.4155188
99establishment of protein localization to mitochondrial membrane (GO:0090151)11.1130005
100chaperone-mediated protein transport (GO:0072321)11.0269388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.11139855
2IGF1R_20145208_ChIP-Seq_DFB_Human5.35463613
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.95305698
4IRF1_19129219_ChIP-ChIP_H3396_Human4.69766707
5VDR_22108803_ChIP-Seq_LS180_Human4.42575815
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10301027
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.83143143
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.30473833
9GBX2_23144817_ChIP-Seq_PC3_Human2.62805124
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.33454111
11ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.30885080
12AUTS2_25519132_ChIP-Seq_293T-REX_Human2.23321112
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14957039
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.07494252
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97012970
16ERG_21242973_ChIP-ChIP_JURKAT_Human1.93057315
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91299411
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.86565837
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86198924
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.81574445
21ZNF274_21170338_ChIP-Seq_K562_Hela1.74976431
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71672381
23CBP_20019798_ChIP-Seq_JUKART_Human1.69515490
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69515490
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69407445
26KAP1_22055183_ChIP-Seq_ESCs_Mouse1.67763444
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62523216
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58246336
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.53142512
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51922592
31AR_21572438_ChIP-Seq_LNCaP_Human1.49558389
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49465518
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42980419
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.42720889
35TP53_16413492_ChIP-PET_HCT116_Human1.41333056
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40793349
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38532862
38MYC_22102868_ChIP-Seq_BL_Human1.33563952
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.32546253
40CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32530229
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29504156
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29171289
43VDR_21846776_ChIP-Seq_THP-1_Human1.28331050
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27712915
45VDR_24787735_ChIP-Seq_THP-1_Human1.26114358
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24133014
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23227227
48TP53_22573176_ChIP-Seq_HFKS_Human1.19287658
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.18907843
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17880571
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15246392
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14883179
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.14716991
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14235573
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05134115
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04837556
57SMAD4_21741376_ChIP-Seq_HESCs_Human1.01341135
58LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.01102291
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99063206
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98254076
61CBP_21632823_ChIP-Seq_H3396_Human0.97965314
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97542518
63LXR_22292898_ChIP-Seq_THP-1_Human0.96220748
64KDM2B_26808549_Chip-Seq_REH_Human0.95702458
65RUNX1_22412390_ChIP-Seq_EML_Mouse0.95229823
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94940569
67NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93566968
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93327220
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91349444
70BCAT_22108803_ChIP-Seq_LS180_Human0.89761355
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88257679
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87943750
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87747384
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86821256
75RUNX_20019798_ChIP-Seq_JUKART_Human0.86159348
76KLF4_19829295_ChIP-Seq_ESCs_Human0.86047082
77CTCF_21964334_Chip-Seq_Bcells_Human0.85703957
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83569851
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82924037
80EZH2_27304074_Chip-Seq_ESCs_Mouse0.81283238
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80365578
82MYC_27129775_Chip-Seq_CORNEA_Mouse0.80331736
83NANOG_20526341_ChIP-Seq_ESCs_Human0.79969665
84FLI1_21867929_ChIP-Seq_TH2_Mouse0.77712751
85VDR_24763502_ChIP-Seq_THP-1_Human0.77422520
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76103107
87AR_25329375_ChIP-Seq_VCAP_Human0.75601372
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.74845657
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.74711061
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.74649668
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74114943
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74097189
93STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74054198
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73581258
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73581258
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73581258
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72814937
98CIITA_25753668_ChIP-Seq_RAJI_Human0.72142966
99EED_16625203_ChIP-ChIP_MESCs_Mouse0.71666538
100TRIM28_21343339_ChIP-Seq_HEK293_Human0.71621913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003786_premature_aging5.42711715
2MP0002876_abnormal_thyroid_physiology4.47851899
3MP0002653_abnormal_ependyma_morphology4.14255310
4MP0004264_abnormal_extraembryonic_tissu3.46315346
5MP0003763_abnormal_thymus_physiology3.18850108
6MP0006082_CNS_inflammation2.88588795
7MP0005671_abnormal_response_to2.76567657
8MP0001986_abnormal_taste_sensitivity2.70251097
9MP0010094_abnormal_chromosome_stability2.58970179
10MP0004885_abnormal_endolymph2.22188681
11MP0008875_abnormal_xenobiotic_pharmacok2.01077871
12MP0008995_early_reproductive_senescence12.9905953
13MP0001849_ear_inflammation1.98533544
14MP0002132_abnormal_respiratory_system1.94468518
15MP0002127_abnormal_cardiovascular_syste1.79629544
16MP0009333_abnormal_splenocyte_physiolog1.79083240
17MP0003111_abnormal_nucleus_morphology1.72700614
18MP0004742_abnormal_vestibular_system1.64061050
19MP0002697_abnormal_eye_size1.61031410
20MP0004270_analgesia1.54400493
21MP0001119_abnormal_female_reproductive1.46384016
22MP0006276_abnormal_autonomic_nervous1.43154902
23MP0004019_abnormal_vitamin_homeostasis1.32921256
24MP0001666_abnormal_nutrient_absorption1.26890997
25MP0003699_abnormal_female_reproductive1.26381611
26MP0003936_abnormal_reproductive_system1.21259590
27MP0001881_abnormal_mammary_gland1.17473878
28MP0000566_synostosis1.16303023
29MP0001542_abnormal_bone_strength1.15454721
30MP0002398_abnormal_bone_marrow1.14107855
31MP0005085_abnormal_gallbladder_physiolo1.07141004
32MP0005025_abnormal_response_to1.06215623
33MP0001661_extended_life_span1.04576089
34MP0002837_dystrophic_cardiac_calcinosis1.00243159
35MP0002420_abnormal_adaptive_immunity0.97591746
36MP0000569_abnormal_digit_pigmentation0.96854199
37MP0009785_altered_susceptibility_to0.95694347
38MP0001790_abnormal_immune_system0.95069127
39MP0005387_immune_system_phenotype0.95069127
40MP0000716_abnormal_immune_system0.93949135
41MP0002210_abnormal_sex_determination0.93114056
42MP0002723_abnormal_immune_serum0.92888913
43MP0001819_abnormal_immune_cell0.91815530
44MP0001485_abnormal_pinna_reflex0.91629367
45MP0002429_abnormal_blood_cell0.85243048
46MP0000627_abnormal_mammary_gland0.76277882
47MP0009046_muscle_twitch0.73740397
48MP0001800_abnormal_humoral_immune0.71823321
49MP0001440_abnormal_grooming_behavior0.71077821
50MP0002734_abnormal_mechanical_nocicepti0.70861136
51MP0005000_abnormal_immune_tolerance0.69258515
52MP0003646_muscle_fatigue0.69135092
53MP0005508_abnormal_skeleton_morphology0.66237337
54MP0003866_abnormal_defecation0.65467177
55MP0005464_abnormal_platelet_physiology0.62485044
56MP0003943_abnormal_hepatobiliary_system0.61339996
57MP0001929_abnormal_gametogenesis0.61160894
58MP0002161_abnormal_fertility/fecundity0.59055068
59MP0003698_abnormal_male_reproductive0.59013214
60MP0001145_abnormal_male_reproductive0.58768013
61MP0000343_altered_response_to0.58415913
62MP0004947_skin_inflammation0.56915680
63MP0009250_abnormal_appendicular_skeleto0.55555863
64MP0002116_abnormal_craniofacial_bone0.55508519
65MP0003195_calcinosis0.55115968
66MP0000653_abnormal_sex_gland0.54963561
67MP0002736_abnormal_nociception_after0.52110189
68MP0001944_abnormal_pancreas_morphology0.51979096
69MP0005275_abnormal_skin_tensile0.51750663
70MP0000703_abnormal_thymus_morphology0.50208337
71MP0008004_abnormal_stomach_pH0.49021316
72MP0008775_abnormal_heart_ventricle0.48470760
73MP0005330_cardiomyopathy0.47263610
74MP0003136_yellow_coat_color0.46791871
75MP0002735_abnormal_chemical_nociception0.45947333
76MP0005084_abnormal_gallbladder_morpholo0.44098828
77MP0000920_abnormal_myelination0.43045924
78MP0003638_abnormal_response/metabolism_0.42466920
79MP0009745_abnormal_behavioral_response0.42109969
80MP0003137_abnormal_impulse_conducting0.41814748
81MP0002722_abnormal_immune_system0.41659650
82MP0003632_abnormal_nervous_system0.41641011
83MP0005266_abnormal_metabolism0.41405279
84MP0005423_abnormal_somatic_nervous0.41260783
85MP0002822_catalepsy0.40697605
86MP0005332_abnormal_amino_acid0.39466039
87MP0002998_abnormal_bone_remodeling0.38659844
88MP0003880_abnormal_central_pattern0.38557705
89MP0005319_abnormal_enzyme/_coenzyme0.38385833
90MP0002088_abnormal_embryonic_growth/wei0.38128070
91MP0005377_hearing/vestibular/ear_phenot0.37389784
92MP0003878_abnormal_ear_physiology0.37389784
93MP0002277_abnormal_respiratory_mucosa0.36589992
94MP0001731_abnormal_postnatal_growth0.36467828
95MP0002064_seizures0.36413296
96MP0003283_abnormal_digestive_organ0.35744001
97MP0004142_abnormal_muscle_tone0.33287474
98MP0002452_abnormal_antigen_presenting0.33070068
99MP0002067_abnormal_sensory_capabilities0.32731619
100MP0001905_abnormal_dopamine_level0.32624786

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal collecting system (HP:0004742)9.19483374
2Reticulocytopenia (HP:0001896)8.97614508
3Chromsome breakage (HP:0040012)8.89640665
4Abnormality of pyrimidine metabolism (HP:0004353)8.31501369
5Abnormality of DNA repair (HP:0003254)7.03507074
6Oral leukoplakia (HP:0002745)6.69156239
7Ureteral duplication (HP:0000073)6.43478799
8Aplastic anemia (HP:0001915)6.39656047
9Duplication of thumb phalanx (HP:0009942)5.80102149
10Ectopic kidney (HP:0000086)5.33575563
11Increased serum pyruvate (HP:0003542)4.88528733
12Absent thumb (HP:0009777)4.45592990
13Autoimmune thrombocytopenia (HP:0001973)4.32804973
14Abnormality of glycolysis (HP:0004366)4.15126094
15Enlarged epiphyses (HP:0010580)4.10189974
16Aplasia/Hypoplasia of the uvula (HP:0010293)4.07604101
17Meckel diverticulum (HP:0002245)3.78054528
18Absent radius (HP:0003974)3.76970925
19Abnormality of the preputium (HP:0100587)3.72563677
20Eosinophilia (HP:0001880)3.62454959
21Aplasia involving forearm bones (HP:0009822)3.60430419
22Absent forearm bone (HP:0003953)3.60430419
23Abnormality of the ileum (HP:0001549)3.56489689
24Thyroid-stimulating hormone excess (HP:0002925)3.55703093
25Pancytopenia (HP:0001876)3.52297078
26Abnormality of B cell number (HP:0010975)3.46149505
27Abnormality of T cell number (HP:0011839)3.43629888
28Stomach cancer (HP:0012126)3.40645330
29Hypergonadotropic hypogonadism (HP:0000815)3.26249903
30Autoimmune hemolytic anemia (HP:0001890)3.23204732
31Rough bone trabeculation (HP:0100670)3.11892936
32Horseshoe kidney (HP:0000085)3.10165860
33Clubbing of toes (HP:0100760)3.09703133
34Renal cortical cysts (HP:0000803)3.09212573
35Abnormality of chromosome stability (HP:0003220)3.08010603
36Increased IgM level (HP:0003496)2.93029782
37Flattened epiphyses (HP:0003071)2.91644968
38Granulocytopenia (HP:0001913)2.88181344
39Abnormality of the carotid arteries (HP:0005344)2.75929289
40Hypoplasia of the capital femoral epiphysis (HP:0003090)2.73916433
41Abnormality of nucleobase metabolism (HP:0010932)2.69749897
42Increased hepatocellular lipid droplets (HP:0006565)2.60969315
43Joint swelling (HP:0001386)2.59988112
44Abnormality of eosinophils (HP:0001879)2.59700712
45Abnormality of reticulocytes (HP:0004312)2.54751096
46Abnormality of T cells (HP:0002843)2.48185075
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40960374
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.39738739
49Leukopenia (HP:0001882)2.39548179
50Small intestinal stenosis (HP:0012848)2.39387630
51Duodenal stenosis (HP:0100867)2.39387630
52Bone marrow hypocellularity (HP:0005528)2.38767584
53Abnormal trabecular bone morphology (HP:0100671)2.36406392
54Neutropenia (HP:0001875)2.35420763
55Cellular immunodeficiency (HP:0005374)2.35017522
56Syringomyelia (HP:0003396)2.34811578
57Spinal cord lesions (HP:0100561)2.34811578
58Absent epiphyses (HP:0010577)2.27802369
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27802369
60Abnormality of the vertebral endplates (HP:0005106)2.25446207
61Lipid accumulation in hepatocytes (HP:0006561)2.21723495
62Short thumb (HP:0009778)2.21073118
63Abnormality of the epiphysis of the femoral head (HP:0010574)2.16848043
64Renal Fanconi syndrome (HP:0001994)2.13203417
65Partial duplication of the phalanx of hand (HP:0009999)2.12062852
66Megalocornea (HP:0000485)2.05435344
67Duplicated collecting system (HP:0000081)10.3280159
68Chromosomal breakage induced by crosslinking agents (HP:0003221)10.1503003
69Abnormality of femoral epiphyses (HP:0006499)1.99971221
70Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.99971221
71Renal agenesis (HP:0000104)1.99705089
72T lymphocytopenia (HP:0005403)1.98702612
73Abnormality of the femoral head (HP:0003368)1.97691814
74Tracheoesophageal fistula (HP:0002575)1.95724286
75Abnormality of the duodenum (HP:0002246)1.94225337
76Hypochromic anemia (HP:0001931)1.92974130
77Premature graying of hair (HP:0002216)1.88504229
78Mutism (HP:0002300)1.87790633
79Triphalangeal thumb (HP:0001199)1.83524855
80Exertional dyspnea (HP:0002875)1.73868837
81Progressive neurologic deterioration (HP:0002344)1.72450381
82Pallor (HP:0000980)1.66136693
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.65124160
84Disproportionate short-trunk short stature (HP:0003521)1.64678720
85Thoracic kyphosis (HP:0002942)1.62352334
86Abnormality of cochlea (HP:0000375)1.61155163
87Leukocytosis (HP:0001974)1.60759508
88Abnormality of oral frenula (HP:0000190)1.55803322
89Increased intramyocellular lipid droplets (HP:0012240)1.55084982
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.53916717
91Coronal craniosynostosis (HP:0004440)1.51309661
92Abnormality of the 2nd finger (HP:0004100)1.51254151
93Abnormality of the renal cortex (HP:0011035)1.51219206
94Arteriovenous malformation (HP:0100026)1.51127436
95Abnormality of the parietal bone (HP:0002696)1.48048534
96IgM deficiency (HP:0002850)1.46123675
97Nausea (HP:0002018)1.43965647
98Epiphyseal dysplasia (HP:0002656)1.43684103
99Abnormality of the phalanges of the hallux (HP:0010057)1.40249204
100Astigmatism (HP:0000483)1.38481950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.41669523
2TXK7.37457916
3BCKDK3.71139761
4TAOK312.6915592
5ZAP701.90343308
6TESK21.66686070
7PRPF4B1.65780479
8IKBKE0.95055727
9CAMK1D0.89487448
10TESK10.82480094
11NLK0.77961820
12SGK10.76053908
13TBK10.68924759
14CAMK1G0.65508519
15SYK0.56479317
16ATR0.52793353
17PIK3CA0.50689826
18JAK10.49087221
19TYRO30.48819957
20LCK0.48305507
21ITK0.47905684
22LIMK10.45487655
23LYN0.42233871
24MAPK130.41369511
25HCK0.40743215
26FRK0.35985459
27IGF1R0.32047289
28TLK10.29747927
29INSRR0.28395145
30SGK20.28246719
31CSNK1G10.28125712
32ADRBK20.26834544
33PLK40.26645958
34IKBKB0.25894586
35MAP4K20.25657640
36MAPK120.25262366
37PRKAA20.23805595
38MUSK0.23393159
39OBSCN0.23173994
40ERBB20.21447639
41SRPK10.20666204
42GSK3A0.19173149
43EPHA40.18982501
44FYN0.18401893
45GRK10.18401736
46WNK30.18277929
47AKT20.17833735
48MAP3K50.17824177
49PRKAA10.17433404
50PIM10.16831186
51CSNK1A10.16601121
52TRPM70.16407234
53AKT10.16031005
54ERBB30.15275646
55SGK4940.14117043
56SGK2230.14117043
57TIE10.13658084
58ATM0.12633672
59GRK70.12172858
60MAPK150.11768907
61MAPK30.11683186
62PRKCQ0.11429622
63INSR0.11115500
64MAPKAPK20.08169125
65DAPK30.07621981
66DYRK1A0.07521100
67CAMK10.07463242
68BTK0.07398185
69MAPK140.07021234
70MELK0.06795956
71PRKCA0.06596776
72MTOR0.06588371
73ZAK0.06198267
74ADRBK10.06086108
75PRKCE0.05891074
76CSNK2A10.05647956
77PTK60.05120249
78CDK40.05082453
79RPS6KA50.04692714
80CAMK2A0.04510542
81ERBB40.04227383
82JAK30.04179515
83PRKCB0.03595670
84MAPK80.03535044
85PRKCG0.03189213
86PAK40.03133736
87SGK30.03101029
88RPS6KA40.03026740
89PRKACA0.01406223
90CSNK1E0.01256228
91RPS6KA10.01140700
92RPS6KA30.00647795
93PIK3CG0.00315981
94NTRK2-0.0213618
95CDK1-0.0173458
96OXSR1-0.0155978
97PTK2B-0.0136572
98MATK-0.0106727
99MET-0.0053486
100MAPK1-0.0043926

Predicted pathways (KEGG)

RankGene SetZ-score
1Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006306.28909708
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.04537894
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.91048365
4Pyruvate metabolism_Homo sapiens_hsa006202.85489636
5Fanconi anemia pathway_Homo sapiens_hsa034602.84973914
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.65894061
7Allograft rejection_Homo sapiens_hsa053302.61686739
8Autoimmune thyroid disease_Homo sapiens_hsa053202.55732746
9Graft-versus-host disease_Homo sapiens_hsa053322.55605508
10Galactose metabolism_Homo sapiens_hsa000522.31640130
11Type I diabetes mellitus_Homo sapiens_hsa049402.17630043
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.16806499
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.14200695
14Mismatch repair_Homo sapiens_hsa034302.04722411
15Vitamin digestion and absorption_Homo sapiens_hsa049771.97300360
16Asthma_Homo sapiens_hsa053101.84436906
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81500095
18Linoleic acid metabolism_Homo sapiens_hsa005911.70593867
19Oxidative phosphorylation_Homo sapiens_hsa001901.65965129
20Ether lipid metabolism_Homo sapiens_hsa005651.57116994
21Basal transcription factors_Homo sapiens_hsa030221.53886137
22Staphylococcus aureus infection_Homo sapiens_hsa051501.51925014
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43551295
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42809639
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.42100756
26Propanoate metabolism_Homo sapiens_hsa006401.41262824
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.31189698
28Viral myocarditis_Homo sapiens_hsa054161.27322704
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26269541
30Malaria_Homo sapiens_hsa051441.25661086
31Parkinsons disease_Homo sapiens_hsa050121.18006336
32Hematopoietic cell lineage_Homo sapiens_hsa046401.15672983
33Pancreatic secretion_Homo sapiens_hsa049721.11685221
34T cell receptor signaling pathway_Homo sapiens_hsa046601.10658537
35Cardiac muscle contraction_Homo sapiens_hsa042601.03026682
36Protein export_Homo sapiens_hsa030601.02746505
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00379345
38Ribosome_Homo sapiens_hsa030100.97890654
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97812816
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96451475
41Ovarian steroidogenesis_Homo sapiens_hsa049130.94296788
42Fatty acid biosynthesis_Homo sapiens_hsa000610.93487759
43Phototransduction_Homo sapiens_hsa047440.91626500
44Protein digestion and absorption_Homo sapiens_hsa049740.91125564
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90169444
46Salivary secretion_Homo sapiens_hsa049700.89744471
47Glutamatergic synapse_Homo sapiens_hsa047240.88411307
48Bile secretion_Homo sapiens_hsa049760.84558146
49Butanoate metabolism_Homo sapiens_hsa006500.83320912
50Morphine addiction_Homo sapiens_hsa050320.80497495
51Antigen processing and presentation_Homo sapiens_hsa046120.78398076
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.75896541
53Primary immunodeficiency_Homo sapiens_hsa053400.75111654
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71174593
55Platelet activation_Homo sapiens_hsa046110.69864066
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67541121
57Rheumatoid arthritis_Homo sapiens_hsa053230.66378410
58Systemic lupus erythematosus_Homo sapiens_hsa053220.66087568
59Arachidonic acid metabolism_Homo sapiens_hsa005900.65018765
60Olfactory transduction_Homo sapiens_hsa047400.62166238
61Vitamin B6 metabolism_Homo sapiens_hsa007500.59943247
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59867859
63Alzheimers disease_Homo sapiens_hsa050100.59729376
64Leishmaniasis_Homo sapiens_hsa051400.57828105
65Pertussis_Homo sapiens_hsa051330.56165170
66Serotonergic synapse_Homo sapiens_hsa047260.54074054
67Herpes simplex infection_Homo sapiens_hsa051680.51816639
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51149344
69Circadian entrainment_Homo sapiens_hsa047130.50318297
70Gastric acid secretion_Homo sapiens_hsa049710.48360610
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47719745
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46806798
73Caffeine metabolism_Homo sapiens_hsa002320.45047847
74Proteasome_Homo sapiens_hsa030500.40600193
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39945400
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39234549
77Nicotine addiction_Homo sapiens_hsa050330.38667294
78Taste transduction_Homo sapiens_hsa047420.38249280
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.37912996
80Huntingtons disease_Homo sapiens_hsa050160.37269375
81GABAergic synapse_Homo sapiens_hsa047270.35364923
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34810621
83cAMP signaling pathway_Homo sapiens_hsa040240.34453008
84Retinol metabolism_Homo sapiens_hsa008300.34367596
85Thyroid hormone synthesis_Homo sapiens_hsa049180.34202236
86TNF signaling pathway_Homo sapiens_hsa046680.31672149
87Osteoclast differentiation_Homo sapiens_hsa043800.28295229
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27510891
89Mineral absorption_Homo sapiens_hsa049780.27187112
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25926692
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22455899
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21631014
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.19290976
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17775222
95DNA replication_Homo sapiens_hsa030300.16848930
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.16577989
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16020964
98Synaptic vesicle cycle_Homo sapiens_hsa047210.15916570
99Chemical carcinogenesis_Homo sapiens_hsa052040.14607058
100Calcium signaling pathway_Homo sapiens_hsa040200.13750550

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