ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	8.54280956
2	left/right pattern formation (GO:0060972)	7.33184731
3	ventricular system development (GO:0021591)	7.25780877
4	retinal rod cell development (GO:0046548)	7.04295209
5	retinal cone cell development (GO:0046549)	6.59779518
6	microtubule bundle formation (GO:0001578)	6.24254064
7	left/right axis specification (GO:0070986)	5.65180669
8	protein neddylation (GO:0045116)	5.44059140
9	microtubule depolymerization (GO:0007019)	5.11568129
10	cilium organization (GO:0044782)	5.08226567
11	regulation of microtubule-based movement (GO:0060632)	4.76962012
12	cilium assembly (GO:0042384)	4.61585055
13	intraciliary transport (GO:0042073)	4.48610622
14	microtubule-based movement (GO:0007018)	4.31921753
15	regulation of integrin-mediated signaling pathway (GO:2001044)	4.07151020
16	cellular component assembly involved in morphogenesis (GO:0010927)	4.04489101
17	response to xenobiotic stimulus (GO:0009410)	3.77276304
18	cell projection assembly (GO:0030031)	3.75004763
19	microtubule polymerization or depolymerization (GO:0031109)	3.66258712
20	regulation of interleukin-5 production (GO:0032674)	3.63751862
21	neutrophil activation involved in immune response (GO:0002283)	3.56270406
22	photoreceptor cell maintenance (GO:0045494)	3.55829936
23	primary alcohol catabolic process (GO:0034310)	3.53923843
24	regulation of interleukin-13 production (GO:0032656)	3.53362263
25	lipoxygenase pathway (GO:0019372)	3.52942075
26	protein localization to cilium (GO:0061512)	3.47170086
27	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.43422089
28	cilium morphogenesis (GO:0060271)	3.36491377
29	thrombin receptor signaling pathway (GO:0070493)	3.33722788
30	negative regulation of protein localization to cell surface (GO:2000009)	3.27939801
31	vitamin transmembrane transport (GO:0035461)	3.25680787
32	regulation of germinal center formation (GO:0002634)	3.24998447
33	negative regulation of heart rate (GO:0010459)	3.08623254
34	sperm capacitation (GO:0048240)	3.07974348
35	adenosine receptor signaling pathway (GO:0001973)	3.05733895
36	ethanol metabolic process (GO:0006067)	3.04806116
37	sperm motility (GO:0030317)	3.04331670
38	centriole assembly (GO:0098534)	3.03703431
39	tolerance induction (GO:0002507)	3.03403585
40	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.01850168
41	negative regulation of norepinephrine secretion (GO:0010700)	3.00977843
42	one-carbon compound transport (GO:0019755)	3.00485890
43	lateral ventricle development (GO:0021670)	2.96807116
44	negative regulation of humoral immune response (GO:0002921)	2.94616553
45	diterpenoid biosynthetic process (GO:0016102)	2.93154982
46	nucleoside diphosphate phosphorylation (GO:0006165)	2.90920565
47	glutathione derivative metabolic process (GO:1901685)	2.88797505
48	glutathione derivative biosynthetic process (GO:1901687)	2.88797505
49	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.83359357
50	exogenous drug catabolic process (GO:0042738)	2.82573993
51	regulation of platelet activation (GO:0010543)	2.81500367
52	regulation of platelet aggregation (GO:0090330)	2.78857446
53	negative regulation of appetite (GO:0032099)	2.76413311
54	negative regulation of response to food (GO:0032096)	2.76413311
55	gas transport (GO:0015669)	2.76258973
56	blood coagulation, intrinsic pathway (GO:0007597)	2.70860655
57	negative regulation of thymocyte apoptotic process (GO:0070244)	2.67394892
58	oxygen transport (GO:0015671)	2.67142206
59	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.66865930
60	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.65572975
61	determination of left/right symmetry (GO:0007368)	2.59193064
62	long-chain fatty acid biosynthetic process (GO:0042759)	2.56632658
63	negative regulation of platelet activation (GO:0010544)	2.55394891
64	hypotonic response (GO:0006971)	2.55379849
65	cytoplasmic microtubule organization (GO:0031122)	2.55136391
66	microtubule-based process (GO:0007017)	2.49293712
67	fusion of sperm to egg plasma membrane (GO:0007342)	2.48266791
68	determination of bilateral symmetry (GO:0009855)	2.45646434
69	androgen biosynthetic process (GO:0006702)	2.43822138
70	specification of symmetry (GO:0009799)	2.39625657
71	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.39089765
72	O-glycan processing (GO:0016266)	2.36960883
73	low-density lipoprotein particle remodeling (GO:0034374)	2.34688313
74	extracellular fibril organization (GO:0043206)	2.32864750
75	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.32830810
76	positive regulation of tolerance induction (GO:0002645)	2.32228057
77	multicellular organismal water homeostasis (GO:0050891)	2.30763861
78	positive regulation of endothelial cell differentiation (GO:0045603)	2.30244404
79	lung epithelium development (GO:0060428)	2.30164323
80	platelet aggregation (GO:0070527)	2.29974594
81	glutathione metabolic process (GO:0006749)	2.27866357
82	regulation of norepinephrine secretion (GO:0014061)	2.27026237
83	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.25355703
84	brain morphogenesis (GO:0048854)	2.24672130
85	microtubule severing (GO:0051013)	2.22476518
86	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.20370092
87	drug catabolic process (GO:0042737)	2.15929301
88	regulation of vacuole organization (GO:0044088)	2.13355989
89	reproductive system development (GO:0061458)	2.12869000
90	fibril organization (GO:0097435)	2.12320111
91	hepatocyte differentiation (GO:0070365)	2.11975033
92	negative regulation of heart contraction (GO:0045822)	2.09455481
93	negative regulation of T cell differentiation in thymus (GO:0033085)	2.08859915
94	cilium or flagellum-dependent cell motility (GO:0001539)	18.0410322
95	axonemal dynein complex assembly (GO:0070286)	17.7586594
96	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	15.2942629
97	cilium movement (GO:0003341)	14.7715409
98	motile cilium assembly (GO:0044458)	14.0214868
99	epithelial cilium movement (GO:0003351)	12.3290517
100	axoneme assembly (GO:0035082)	11.5271395

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.73761591
2	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.92314329
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.56032264
4	AR_21572438_ChIP-Seq_LNCaP_Human	2.46238524
5	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.33621109
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25672713
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.12172461
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.10776780
9	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.09983930
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.06583070
11	GATA1_19941826_ChIP-Seq_K562_Human	1.99532033
12	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.95318517
13	GATA2_19941826_ChIP-Seq_K562_Human	1.85033178
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.84322253
15	VDR_22108803_ChIP-Seq_LS180_Human	1.82230163
16	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.80373924
17	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.76452958
18	SCL_19346495_ChIP-Seq_HPC-7_Human	1.72980551
19	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.64197901
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.62054902
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61476593
22	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.59495770
23	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.52564496
24	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.52512728
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52485799
26	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.50764193
27	STAT1_20625510_ChIP-Seq_HELA_Human	1.50031681
28	SMRT_27268052_Chip-Seq_Bcells_Human	1.49791023
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.45238569
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.43492034
31	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.42703898
32	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.41481729
33	GATA4_25053715_ChIP-Seq_YYC3_Human	1.40651471
34	TP53_16413492_ChIP-PET_HCT116_Human	1.38985076
35	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.36926949
36	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.36730993
37	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.34831533
38	SPI1_23127762_ChIP-Seq_K562_Human	1.30839117
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30813283
40	TP63_23658742_ChIP-Seq_EP156T_Human	1.28802243
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28710450
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27512845
43	ERG_20517297_ChIP-Seq_VCAP_Human	1.23710841
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.23416933
45	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.22717416
46	AR_20517297_ChIP-Seq_VCAP_Human	1.22029251
47	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.19674344
48	SOX2_20726797_ChIP-Seq_SW620_Human	1.17634043
49	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.16849981
50	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.16795839
51	GBX2_23144817_ChIP-Seq_PC3_Human	1.16748474
52	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.16351242
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16236272
54	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.16071705
55	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14424466
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.13223801
57	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.13101892
58	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12449042
59	RBPJ_21746931_ChIP-Seq_IB4_Human	1.12343633
60	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.12071160
61	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.11800962
62	CEBPB_22108803_ChIP-Seq_LS180_Human	1.11166695
63	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10732827
64	NFYA_21822215_ChIP-Seq_K562_Human	1.10607148
65	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.10605147
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.10549688
67	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.09732035
68	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.09411242
69	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.09306965
70	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.07876454
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07789348
72	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.07467915
73	STAT3_23295773_ChIP-Seq_U87_Human	1.06659779
74	PHF8_20622853_ChIP-Seq_HELA_Human	1.06148090
75	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.05590707
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04677764
77	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04523040
78	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.04460002
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04339398
80	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.03652779
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03600784
82	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.03501312
83	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.03204227
84	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.02968378
85	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.02581420
86	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.01518754
87	TBL1_22424771_ChIP-Seq_293T_Human	1.01358343
88	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.00181947
89	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99586859
90	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.98913741
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.98913741
92	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98352655
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98317843
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98317843
95	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98238942
96	SPI1_20517297_ChIP-Seq_HL60_Human	0.97891529
97	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.97580053
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96788807
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96788807
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96629471

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	6.56654797
2	MP0002653_abnormal_ependyma_morphology	5.64988798
3	MP0008875_abnormal_xenobiotic_pharmacok	4.41075597
4	MP0005083_abnormal_biliary_tract	4.10531925
5	MP0002132_abnormal_respiratory_system	4.07105208
6	MP0008004_abnormal_stomach_pH	3.83245616
7	MP0005623_abnormal_meninges_morphology	3.07165195
8	MP0009780_abnormal_chondrocyte_physiolo	2.59548450
9	MP0004043_abnormal_pH_regulation	2.53612720
10	MP0000465_gastrointestinal_hemorrhage	2.50857911
11	MP0000383_abnormal_hair_follicle	2.37409352
12	MP0001879_abnormal_lymphatic_vessel	1.96369111
13	MP0002277_abnormal_respiratory_mucosa	1.81812977
14	MP0001984_abnormal_olfaction	1.71240861
15	MP0001765_abnormal_ion_homeostasis	1.68241174
16	MP0010678_abnormal_skin_adnexa	1.63598354
17	MP0001835_abnormal_antigen_presentation	1.62625819
18	MP0003656_abnormal_erythrocyte_physiolo	1.62119159
19	MP0003303_peritoneal_inflammation	1.60473833
20	MP0003724_increased_susceptibility_to	1.57235801
21	MP0010155_abnormal_intestine_physiology	1.57106423
22	MP0008872_abnormal_physiological_respon	1.56082410
23	MP0004133_heterotaxia	1.55179229
24	MP0005253_abnormal_eye_physiology	1.53796084
25	MP0005377_hearing/vestibular/ear_phenot	1.51518375
26	MP0003878_abnormal_ear_physiology	1.51518375
27	MP0008789_abnormal_olfactory_epithelium	1.48601977
28	MP0005646_abnormal_pituitary_gland	1.44601182
29	MP0003566_abnormal_cell_adhesion	1.38763445
30	MP0005551_abnormal_eye_electrophysiolog	1.36004231
31	MP0005165_increased_susceptibility_to	1.31693689
32	MP0000343_altered_response_to	1.28967550
33	MP0001346_abnormal_lacrimal_gland	1.28841283
34	MP0000230_abnormal_systemic_arterial	1.28069320
35	MP0010329_abnormal_lipoprotein_level	1.27789589
36	MP0001663_abnormal_digestive_system	1.26375792
37	MP0009765_abnormal_xenobiotic_induced	1.25719866
38	MP0002736_abnormal_nociception_after	1.21142848
39	MP0009763_increased_sensitivity_to	1.20420422
40	MP0009643_abnormal_urine_homeostasis	1.19421376
41	MP0003638_abnormal_response/metabolism_	1.15461474
42	MP0001851_eye_inflammation	1.14079843
43	MP0005636_abnormal_mineral_homeostasis	1.11430308
44	MP0010368_abnormal_lymphatic_system	1.09166630
45	MP0002148_abnormal_hypersensitivity_rea	1.09074914
46	MP0003950_abnormal_plasma_membrane	1.08976102
47	MP0002160_abnormal_reproductive_system	1.08863108
48	MP0005410_abnormal_fertilization	1.06162556
49	MP0002282_abnormal_trachea_morphology	1.04960907
50	MP0005395_other_phenotype	1.04435454
51	MP0002168_other_aberrant_phenotype	1.04393122
52	MP0003718_maternal_effect	1.00805586
53	MP0005167_abnormal_blood-brain_barrier	0.98206368
54	MP0005085_abnormal_gallbladder_physiolo	0.98100495
55	MP0001790_abnormal_immune_system	0.97309993
56	MP0005387_immune_system_phenotype	0.97309993
57	MP0004215_abnormal_myocardial_fiber	0.96681149
58	MP0002136_abnormal_kidney_physiology	0.94710819
59	MP0003879_abnormal_hair_cell	0.93615717
60	MP0003828_pulmonary_edema	0.93541948
61	MP0001970_abnormal_pain_threshold	0.90542177
62	MP0003866_abnormal_defecation	0.90225516
63	MP0002735_abnormal_chemical_nociception	0.84893251
64	MP0004947_skin_inflammation	0.84649072
65	MP0001664_abnormal_digestion	0.84516970
66	MP0005499_abnormal_olfactory_system	0.82445698
67	MP0005394_taste/olfaction_phenotype	0.82445698
68	MP0000249_abnormal_blood_vessel	0.82182769
69	MP0009642_abnormal_blood_homeostasis	0.82170722
70	MP0005365_abnormal_bile_salt	0.81664500
71	MP0005084_abnormal_gallbladder_morpholo	0.81641125
72	MP0000858_altered_metastatic_potential	0.81042581
73	MP0005023_abnormal_wound_healing	0.81024223
74	MP0005248_abnormal_Harderian_gland	0.80830061
75	MP0005381_digestive/alimentary_phenotyp	0.80584257
76	MP0004019_abnormal_vitamin_homeostasis	0.80443524
77	MP0002405_respiratory_system_inflammati	0.76862707
78	MP0004036_abnormal_muscle_relaxation	0.76346371
79	MP0008961_abnormal_basal_metabolism	0.75943732
80	MP0005000_abnormal_immune_tolerance	0.73076933
81	MP0009046_muscle_twitch	0.71899385
82	MP0004084_abnormal_cardiac_muscle	0.71534613
83	MP0002733_abnormal_thermal_nociception	0.70090022
84	MP0005671_abnormal_response_to	0.69266280
85	MP0002909_abnormal_adrenal_gland	0.68019201
86	MP0005310_abnormal_salivary_gland	0.67799186
87	MP0005397_hematopoietic_system_phenotyp	0.67165123
88	MP0001545_abnormal_hematopoietic_system	0.67165123
89	MP0001666_abnormal_nutrient_absorption	0.66712321
90	MP0006138_congestive_heart_failure	0.65656679
91	MP0005164_abnormal_response_to	0.64992480
92	MP0005389_reproductive_system_phenotype	0.63658466
93	MP0006036_abnormal_mitochondrial_physio	0.63497918
94	MP0002118_abnormal_lipid_homeostasis	0.62415533
95	MP0001845_abnormal_inflammatory_respons	0.61586990
96	MP0001756_abnormal_urination	0.61362737
97	MP0001849_ear_inflammation	0.61191240
98	MP0002135_abnormal_kidney_morphology	0.61155710
99	MP0005195_abnormal_posterior_eye	0.60366463
100	MP0001968_abnormal_touch/_nociception	0.60002719

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rhinitis (HP:0012384)	8.75468269
2	Chronic bronchitis (HP:0004469)	7.32039844
3	Bronchiectasis (HP:0002110)	6.61699438
4	Nasal polyposis (HP:0100582)	6.30411920
5	Abnormality of the nasal mucosa (HP:0000433)	5.18058119
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.55618517
7	Bronchitis (HP:0012387)	4.41354507
8	Recurrent sinusitis (HP:0011108)	4.08381522
9	Infertility (HP:0000789)	4.03629071
10	Chronic sinusitis (HP:0011109)	3.98562974
11	Recurrent otitis media (HP:0000403)	3.62527068
12	Prolonged bleeding time (HP:0003010)	3.52770633
13	Chronic hepatic failure (HP:0100626)	3.51260757
14	Male infertility (HP:0003251)	3.49509065
15	Tubulointerstitial nephritis (HP:0001970)	3.09600924
16	Purpura (HP:0000979)	3.07374326
17	Menorrhagia (HP:0000132)	3.01383332
18	Hyperactive renin-angiotensin system (HP:0000841)	2.87124946
19	Petechiae (HP:0000967)	2.76508163
20	Increased mean platelet volume (HP:0011877)	2.75149055
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.70538979
22	Chronic otitis media (HP:0000389)	2.58923318
23	Abnormal platelet volume (HP:0011876)	2.52500874
24	Recurrent bronchitis (HP:0002837)	2.41508337
25	Occipital encephalocele (HP:0002085)	2.37380354
26	Pancreatic fibrosis (HP:0100732)	2.30336306
27	Atelectasis (HP:0100750)	2.24167673
28	Molar tooth sign on MRI (HP:0002419)	2.21700124
29	Abnormality of midbrain morphology (HP:0002418)	2.21700124
30	True hermaphroditism (HP:0010459)	2.19961807
31	Epistaxis (HP:0000421)	2.18712802
32	Decreased circulating renin level (HP:0003351)	2.15898144
33	Nephronophthisis (HP:0000090)	2.09840353
34	Absent/shortened dynein arms (HP:0200106)	12.3696896
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	12.3696896
36	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	11.2741389
37	Abnormal ciliary motility (HP:0012262)	10.8371244
38	Abnormal respiratory epithelium morphology (HP:0012253)	10.6834591
39	Abnormal respiratory motile cilium morphology (HP:0005938)	10.6834591
40	Abnormal respiratory motile cilium physiology (HP:0012261)	10.3357610
41	Cone-rod dystrophy (HP:0000548)	1.94022857
42	Bony spicule pigmentary retinopathy (HP:0007737)	1.92426238
43	Pancreatic cysts (HP:0001737)	1.83782094
44	Hyperlipoproteinemia (HP:0010980)	1.82674726
45	Renal salt wasting (HP:0000127)	1.75740626
46	Gingival bleeding (HP:0000225)	1.73528904
47	Abnormality of the renal medulla (HP:0100957)	1.70813810
48	Menstrual irregularities (HP:0000858)	1.70752438
49	Constricted visual fields (HP:0001133)	1.68918525
50	Cystic liver disease (HP:0006706)	1.68812105
51	Medial flaring of the eyebrow (HP:0010747)	1.66115633
52	Male pseudohermaphroditism (HP:0000037)	1.62824257
53	Dyschromatopsia (HP:0007641)	1.61443416
54	Abnormal platelet function (HP:0011869)	1.57490602
55	Impaired platelet aggregation (HP:0003540)	1.57490602
56	Postaxial foot polydactyly (HP:0001830)	1.56499036
57	Decreased central vision (HP:0007663)	1.53145906
58	Congenital primary aphakia (HP:0007707)	1.49105803
59	Hyperaldosteronism (HP:0000859)	1.48693330
60	Hypokalemic alkalosis (HP:0001949)	1.47372627
61	Congenital hepatic fibrosis (HP:0002612)	1.47151242
62	Progressive sensorineural hearing impairment (HP:0000408)	1.44431161
63	Gait imbalance (HP:0002141)	1.43458200
64	Tubulointerstitial abnormality (HP:0001969)	1.42578638
65	Nephropathy (HP:0000112)	1.42433896
66	Bell-shaped thorax (HP:0001591)	1.41791989
67	Acanthocytosis (HP:0001927)	1.38524952
68	Hyperkalemia (HP:0002153)	1.37533606
69	Portal hypertension (HP:0001409)	1.35878956
70	Abnormality of renin-angiotensin system (HP:0000847)	1.34760369
71	Nephrogenic diabetes insipidus (HP:0009806)	1.30486285
72	Poikilocytosis (HP:0004447)	1.28046780
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.26907862
74	Abnormality of the hepatic vasculature (HP:0006707)	1.21859400
75	Anencephaly (HP:0002323)	1.18617646
76	Joint swelling (HP:0001386)	1.18613412
77	Abnormality of chloride homeostasis (HP:0011422)	1.13116860
78	Median cleft lip (HP:0000161)	1.13098564
79	Ventricular fibrillation (HP:0001663)	1.12045282
80	Tubular atrophy (HP:0000092)	1.11234563
81	Abnormality of the fingertips (HP:0001211)	1.09221846
82	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.08820803
83	Abnormal hair whorl (HP:0010721)	1.07490240
84	Insulin-resistant diabetes mellitus (HP:0000831)	1.07479880
85	Recurrent pneumonia (HP:0006532)	1.06791089
86	Hyponatremia (HP:0002902)	1.05366807
87	Progressive hearing impairment (HP:0001730)	1.04273966
88	Poor coordination (HP:0002370)	1.03972551
89	Asplenia (HP:0001746)	1.03282311
90	Hypoalphalipoproteinemia (HP:0003233)	1.02907083
91	Supernumerary spleens (HP:0009799)	1.02598445
92	Postaxial hand polydactyly (HP:0001162)	1.01320650
93	Aortic aneurysm (HP:0004942)	1.01264682
94	Genital tract atresia (HP:0001827)	1.00273357
95	Vaginal atresia (HP:0000148)	1.00198187
96	Aplasia/Hypoplasia of the spleen (HP:0010451)	0.99359898
97	Furrowed tongue (HP:0000221)	0.99290431
98	Oculomotor apraxia (HP:0000657)	0.97557670
99	Stage 5 chronic kidney disease (HP:0003774)	0.97122927
100	Abnormality of sodium homeostasis (HP:0010931)	0.95922026

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	8.18796398
2	MAPK15	7.03029452
3	RIPK4	2.88891541
4	MYLK	2.63095516
5	BMX	2.52007068
6	PTK2B	2.50365796
7	STK16	2.36303062
8	MAPKAPK3	2.07955571
9	EPHA2	2.04402855
10	EIF2AK1	1.86710266
11	STK24	1.80562432
12	ZAP70	1.79443535
13	TEC	1.67056211
14	BTK	1.66684934
15	IRAK1	1.66634811
16	BCR	1.60007676
17	ERBB2	1.49995039
18	TLK1	1.49375897
19	ILK	1.40093244
20	MAP3K2	1.39021888
21	PNCK	1.29713013
22	MAP3K3	1.29025645
23	GRK6	1.28901889
24	CSK	1.26696388
25	STK3	1.23024002
26	CDK12	1.15461057
27	GRK5	1.10356657
28	LMTK2	1.04621251
29	NME1	1.01906757
30	ADRBK2	1.01701106
31	LRRK2	0.96085357
32	PIK3CG	0.95550877
33	ACVR1B	0.93981198
34	PAK1	0.93688331
35	CSF1R	0.93610193
36	MST1R	0.90656457
37	TYK2	0.86605502
38	BLK	0.85272806
39	SYK	0.81517410
40	AURKA	0.80374935
41	EPHA3	0.79512401
42	STK10	0.79253251
43	FER	0.77123051
44	BMPR2	0.77067695
45	MAP3K12	0.74203530
46	MARK2	0.71489851
47	ADRBK1	0.71476838
48	BMPR1B	0.71035156
49	PRKCI	0.69412045
50	TAOK1	0.68867075
51	IKBKB	0.64894831
52	IRAK2	0.64417456
53	HCK	0.63507842
54	PIM2	0.62976703
55	TAOK3	0.60611338
56	EPHB1	0.60269446
57	TRIM28	0.58529239
58	PRKD1	0.58362960
59	DAPK3	0.57409700
60	SGK2	0.57386203
61	TRPM7	0.53685944
62	CDC42BPA	0.53496146
63	FYN	0.48344563
64	PRKCQ	0.46679118
65	FGR	0.45658495
66	LYN	0.44793180
67	TNK2	0.43883960
68	MET	0.43042893
69	PRKCD	0.41609942
70	GRK1	0.41262657
71	MAP2K7	0.40893132
72	MAP2K1	0.40815391
73	ROCK1	0.40308606
74	TESK1	0.37575391
75	CAMK2G	0.36745287
76	DAPK1	0.32830745
77	CDK8	0.31385664
78	ITK	0.30112745
79	BRSK2	0.29715688
80	MUSK	0.29567856
81	PAK3	0.28590949
82	TESK2	0.28580322
83	PRKCA	0.28340590
84	STK4	0.27914746
85	PDPK1	0.27843288
86	TTK	0.27452136
87	RET	0.27029923
88	MAP3K5	0.26721013
89	MAP3K7	0.26222228
90	FRK	0.26081548
91	MAPKAPK2	0.25724769
92	MATK	0.25550234
93	IGF1R	0.25539415
94	PRKG1	0.25456420
95	RPS6KA2	0.25239287
96	PRKACG	0.24146178
97	PKN1	0.23805366
98	ABL1	0.23187338
99	CAMK2A	0.23125047
100	ERBB3	0.23028840

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	4.02847350
2	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.64118543
3	Chemical carcinogenesis_Homo sapiens_hsa05204	3.43992837
4	Platelet activation_Homo sapiens_hsa04611	2.86826865
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.59170418
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.53697641
7	Huntingtons disease_Homo sapiens_hsa05016	2.28444250
8	Histidine metabolism_Homo sapiens_hsa00340	2.28040613
9	Glutathione metabolism_Homo sapiens_hsa00480	2.25130657
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.21149715
11	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.14199134
12	Phenylalanine metabolism_Homo sapiens_hsa00360	2.07907131
13	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.04614959
14	Linoleic acid metabolism_Homo sapiens_hsa00591	2.04487265
15	Tyrosine metabolism_Homo sapiens_hsa00350	2.03867287
16	Retinol metabolism_Homo sapiens_hsa00830	2.02072764
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.01540136
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.95612164
19	beta-Alanine metabolism_Homo sapiens_hsa00410	1.85115127
20	ABC transporters_Homo sapiens_hsa02010	1.62642794
21	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.59974258
22	Sphingolipid metabolism_Homo sapiens_hsa00600	1.59287462
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.55102110
24	Caffeine metabolism_Homo sapiens_hsa00232	1.52083292
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.46959838
26	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.42877567
27	ECM-receptor interaction_Homo sapiens_hsa04512	1.38723415
28	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.32934299
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.31059974
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24274144
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.22046503
32	Serotonergic synapse_Homo sapiens_hsa04726	1.22012756
33	Alcoholism_Homo sapiens_hsa05034	0.98138022
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98110477
35	Gap junction_Homo sapiens_hsa04540	0.97131292
36	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.96349498
37	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.94273400
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.93503663
39	Circadian rhythm_Homo sapiens_hsa04710	0.93093089
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.92719953
41	Olfactory transduction_Homo sapiens_hsa04740	0.91980402
42	Chemokine signaling pathway_Homo sapiens_hsa04062	0.91745116
43	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.90251424
44	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.86088016
45	Endocytosis_Homo sapiens_hsa04144	0.82533672
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77445217
47	Tight junction_Homo sapiens_hsa04530	0.76421112
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73249334
49	Adherens junction_Homo sapiens_hsa04520	0.73152163
50	Pancreatic secretion_Homo sapiens_hsa04972	0.72260706
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71505562
52	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.71202496
53	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.66355202
54	Choline metabolism in cancer_Homo sapiens_hsa05231	0.64822207
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61136901
56	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60789877
57	Salivary secretion_Homo sapiens_hsa04970	0.54351193
58	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.52624699
59	Notch signaling pathway_Homo sapiens_hsa04330	0.51484583
60	Phagosome_Homo sapiens_hsa04145	0.49529590
61	Shigellosis_Homo sapiens_hsa05131	0.48448877
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.48396750
63	Phototransduction_Homo sapiens_hsa04744	0.46380470
64	Peroxisome_Homo sapiens_hsa04146	0.45820969
65	Amoebiasis_Homo sapiens_hsa05146	0.42851743
66	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.42372446
67	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.42252271
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41869003
69	Complement and coagulation cascades_Homo sapiens_hsa04610	0.41317936
70	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.40181656
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.40071952
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.39756107
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39494792
74	Asthma_Homo sapiens_hsa05310	0.38032211
75	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.37819219
76	Regulation of autophagy_Homo sapiens_hsa04140	0.36968094
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36697410
78	Allograft rejection_Homo sapiens_hsa05330	0.35895660
79	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35568398
80	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35022305
81	Sulfur metabolism_Homo sapiens_hsa00920	0.34354106
82	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.34289919
83	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.34243536
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.34221931
85	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.33915565
86	Malaria_Homo sapiens_hsa05144	0.33533039
87	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.31787146
88	Ras signaling pathway_Homo sapiens_hsa04014	0.31580947
89	Circadian entrainment_Homo sapiens_hsa04713	0.30945033
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.30599487
91	Focal adhesion_Homo sapiens_hsa04510	0.28156079
92	Taste transduction_Homo sapiens_hsa04742	0.27475636
93	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.27346399
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.26795329
95	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.26769939
96	Hepatitis C_Homo sapiens_hsa05160	0.23396835
97	Salmonella infection_Homo sapiens_hsa05132	0.22929348
98	Fatty acid elongation_Homo sapiens_hsa00062	0.22570846
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.22170318
100	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.22029072

OR7E36P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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