ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	4.87837494
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.49424553
3	ribosomal small subunit biogenesis (GO:0042274)	4.49027578
4	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.24266946
5	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.79384331
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.75764198
7	proteasome assembly (GO:0043248)	3.68305509
8	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.53332260
9	protein targeting to mitochondrion (GO:0006626)	3.44464155
10	GDP-mannose metabolic process (GO:0019673)	3.41179033
11	ribosomal small subunit assembly (GO:0000028)	3.35587864
12	telomere maintenance via semi-conservative replication (GO:0032201)	3.33421353
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.33039483
14	ATP synthesis coupled proton transport (GO:0015986)	3.33039483
15	deoxyribonucleotide catabolic process (GO:0009264)	3.27833824
16	inner mitochondrial membrane organization (GO:0007007)	3.24632496
17	viral transcription (GO:0019083)	3.23668245
18	nucleobase-containing small molecule interconversion (GO:0015949)	3.14618799
19	pyrimidine-containing compound salvage (GO:0008655)	3.14327051
20	pyrimidine nucleoside salvage (GO:0043097)	3.14327051
21	deoxyribose phosphate catabolic process (GO:0046386)	3.12850684
22	establishment of protein localization to mitochondrion (GO:0072655)	3.11432571
23	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.11356406
24	protein targeting to ER (GO:0045047)	3.10085031
25	DNA strand elongation involved in DNA replication (GO:0006271)	3.08915038
26	translational termination (GO:0006415)	3.04917258
27	pseudouridine synthesis (GO:0001522)	3.04647103
28	protein localization to endoplasmic reticulum (GO:0070972)	3.03030427
29	ribonucleoprotein complex biogenesis (GO:0022613)	3.02937505
30	cotranslational protein targeting to membrane (GO:0006613)	3.01983367
31	DNA strand elongation (GO:0022616)	3.01820438
32	formation of translation preinitiation complex (GO:0001731)	3.01259636
33	mitotic chromosome condensation (GO:0007076)	3.00996982
34	protein localization to mitochondrion (GO:0070585)	2.97915006
35	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.97903428
36	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.97835686
37	pyrimidine nucleotide catabolic process (GO:0006244)	2.97401123
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.93809073
39	DNA deamination (GO:0045006)	2.93446631
40	nucleoside salvage (GO:0043174)	2.92775867
41	maturation of SSU-rRNA (GO:0030490)	2.90425920
42	rRNA modification (GO:0000154)	2.90009817
43	protein maturation by protein folding (GO:0022417)	2.88277945
44	purine deoxyribonucleotide catabolic process (GO:0009155)	2.87470410
45	folic acid-containing compound biosynthetic process (GO:0009396)	2.86865742
46	respiratory electron transport chain (GO:0022904)	2.85179353
47	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.84756168
48	regulation of mitochondrial translation (GO:0070129)	2.84749026
49	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.83009352
50	deoxyribose phosphate biosynthetic process (GO:0046385)	2.83009352
51	nucleotide salvage (GO:0043173)	2.82262871
52	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.82127547
53	ribosomal large subunit biogenesis (GO:0042273)	2.81346765
54	pteridine-containing compound biosynthetic process (GO:0042559)	2.81187671
55	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.80539769
56	translational elongation (GO:0006414)	2.80525992
57	cellular response to arsenic-containing substance (GO:0071243)	2.78313359
58	regulation of DNA methylation (GO:0044030)	2.77865308
59	translation (GO:0006412)	2.76808497
60	telomere maintenance via recombination (GO:0000722)	2.75667538
61	electron transport chain (GO:0022900)	2.75602724
62	cellular component biogenesis (GO:0044085)	2.74076041
63	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.73657321
64	regulation of cellular amino acid metabolic process (GO:0006521)	2.72473405
65	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.72003273
66	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.70849748
67	negative regulation of ligase activity (GO:0051352)	2.70849748
68	viral life cycle (GO:0019058)	2.69157446
69	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.68291003
70	ribosome biogenesis (GO:0042254)	2.67330222
71	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.67101062
72	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.67101062
73	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.65088166
74	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.65088166
75	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.65088166
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.63540647
77	termination of RNA polymerase III transcription (GO:0006386)	2.63540647
78	base-excision repair, AP site formation (GO:0006285)	2.63136312
79	establishment of chromosome localization (GO:0051303)	2.62684489
80	mitotic metaphase plate congression (GO:0007080)	2.60974403
81	regulation of chemokine biosynthetic process (GO:0045073)	2.60328922
82	autophagic vacuole fusion (GO:0000046)	2.60170358
83	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.59675953
84	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.59675953
85	2-deoxyribonucleotide metabolic process (GO:0009394)	2.58792340
86	translational initiation (GO:0006413)	2.58289216
87	positive regulation of ligase activity (GO:0051351)	2.57814844
88	deoxyribonucleotide metabolic process (GO:0009262)	2.56118329
89	deoxyribose phosphate metabolic process (GO:0019692)	2.52478468
90	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.50365554
91	pentose metabolic process (GO:0019321)	2.50238996
92	deoxyribonucleotide biosynthetic process (GO:0009263)	2.48560786
93	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.45531954
94	purine nucleotide salvage (GO:0032261)	2.45287735
95	mitotic recombination (GO:0006312)	2.44813491
96	organelle membrane fusion (GO:0090174)	2.44040689
97	protein localization to chromosome, centromeric region (GO:0071459)	2.43233648
98	L-phenylalanine metabolic process (GO:0006558)	2.41510072
99	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.41510072
100	protein deneddylation (GO:0000338)	2.41295571

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.69809086
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58202757
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.46066587
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.32906856
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.14876718
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.14191880
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.99194212
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.84946866
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.72302636
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.71902217
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.71356356
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.56915784
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.47784373
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.43069176
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.42737021
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.39784137
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.38448911
18	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.20516425
19	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.12449083
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12210731
21	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.10787035
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00632355
23	VDR_21846776_ChIP-Seq_THP-1_Human	1.97198924
24	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.95590756
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.93975961
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.93480025
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.91828730
28	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.90120196
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.90107639
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.86756345
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84734504
32	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.79182309
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.77862891
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.76333795
35	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.75124746
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.71619532
37	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.67173780
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.62870593
39	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.60637651
40	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.59551324
41	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.59273614
42	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.59160060
43	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.58301744
44	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.57123980
45	MYC_22102868_ChIP-Seq_BL_Human	1.56156837
46	TFEB_21752829_ChIP-Seq_HELA_Human	1.54664875
47	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.54517844
48	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.53341073
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53256049
50	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.52883901
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49479983
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.48366600
53	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.47865496
54	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.46822113
55	KDM5A_27292631_Chip-Seq_BREAST_Human	1.44421255
56	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.41668394
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.39580589
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.38991989
59	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.38604296
60	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.38088074
61	SPI1_23547873_ChIP-Seq_NB4_Human	1.33692526
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32239971
63	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.29365957
64	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29318744
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.29278235
66	MAF_26560356_Chip-Seq_TH2_Human	1.29004635
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27642411
68	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.26763971
69	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.26445095
70	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.26196564
71	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.22630925
72	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21027596
73	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.20580496
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.19986984
75	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.19184972
76	ZNF263_19887448_ChIP-Seq_K562_Human	1.18923299
77	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.17982517
78	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.17423702
79	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.16177890
80	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13885062
81	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.13804196
82	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.12735120
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10328821
84	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.07040156
85	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.06337118
86	VDR_24763502_ChIP-Seq_THP-1_Human	1.06259487
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02993563
88	CTCF_21964334_Chip-Seq_Bcells_Human	1.00298731
89	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.98535195
90	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.97643920
91	AR_21909140_ChIP-Seq_LNCAP_Human	0.96336129
92	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.96246140
93	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.94436128
94	UTX_26944678_Chip-Seq_JUKART_Human	0.93654594
95	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.93409123
96	BCL6_27268052_Chip-Seq_Bcells_Human	0.92558138
97	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.92467056
98	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.91871844
99	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.91346069
100	ELF5_23300383_ChIP-Seq_T47D_Human	0.90644056

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.98228015
2	MP0005451_abnormal_body_composition	3.53661234
3	MP0003718_maternal_effect	2.87295005
4	MP0009333_abnormal_splenocyte_physiolog	2.82674594
5	MP0010094_abnormal_chromosome_stability	2.79028329
6	MP0003693_abnormal_embryo_hatching	2.65623180
7	MP0005671_abnormal_response_to	2.57509141
8	MP0003111_abnormal_nucleus_morphology	2.53821582
9	MP0003786_premature_aging	2.37251052
10	MP0003077_abnormal_cell_cycle	2.32853601
11	MP0005408_hypopigmentation	2.32381932
12	MP0003763_abnormal_thymus_physiology	2.28365830
13	MP0006036_abnormal_mitochondrial_physio	2.15425111
14	MP0004957_abnormal_blastocyst_morpholog	2.01781079
15	MP0001835_abnormal_antigen_presentation	2.00899082
16	MP0009785_altered_susceptibility_to	1.93855586
17	MP0005058_abnormal_lysosome_morphology	1.93335433
18	MP0003186_abnormal_redox_activity	1.92444618
19	MP0002148_abnormal_hypersensitivity_rea	1.92201353
20	MP0005000_abnormal_immune_tolerance	1.77053456
21	MP0000372_irregular_coat_pigmentation	1.73812019
22	MP0001873_stomach_inflammation	1.72590807
23	MP0008058_abnormal_DNA_repair	1.69488081
24	MP0001800_abnormal_humoral_immune	1.66695082
25	MP0006082_CNS_inflammation	1.64987468
26	MP0004233_abnormal_muscle_weight	1.61144432
27	MP0001853_heart_inflammation	1.58816213
28	MP0005464_abnormal_platelet_physiology	1.54542645
29	MP0002723_abnormal_immune_serum	1.53085403
30	MP0002398_abnormal_bone_marrow	1.52992632
31	MP0002132_abnormal_respiratory_system	1.50290420
32	MP0008995_early_reproductive_senescence	1.50110889
33	MP0008057_abnormal_DNA_replication	1.49133589
34	MP0008007_abnormal_cellular_replicative	1.48484211
35	MP0002420_abnormal_adaptive_immunity	1.47491116
36	MP0002452_abnormal_antigen_presenting	1.45900711
37	MP0000685_abnormal_immune_system	1.45247969
38	MP0001819_abnormal_immune_cell	1.44153071
39	MP0009840_abnormal_foam_cell	1.39590608
40	MP0005360_urolithiasis	1.35199129
41	MP0005025_abnormal_response_to	1.35031120
42	MP0002139_abnormal_hepatobiliary_system	1.33585203
43	MP0001790_abnormal_immune_system	1.33541164
44	MP0005387_immune_system_phenotype	1.33541164
45	MP0008004_abnormal_stomach_pH	1.33538431
46	MP0008932_abnormal_embryonic_tissue	1.33368964
47	MP0002877_abnormal_melanocyte_morpholog	1.32235043
48	MP0004381_abnormal_hair_follicle	1.31442144
49	MP0002837_dystrophic_cardiac_calcinosis	1.28962723
50	MP0000358_abnormal_cell_content/	1.27808111
51	MP0000716_abnormal_immune_system	1.26795650
52	MP0003436_decreased_susceptibility_to	1.23854748
53	MP0002419_abnormal_innate_immunity	1.22664162
54	MP0000015_abnormal_ear_pigmentation	1.21499040
55	MP0002429_abnormal_blood_cell	1.21034708
56	MP0002019_abnormal_tumor_incidence	1.20684327
57	MP0006035_abnormal_mitochondrial_morpho	1.19070298
58	MP0008789_abnormal_olfactory_epithelium	1.16871161
59	MP0002722_abnormal_immune_system	1.14821226
60	MP0005395_other_phenotype	1.14269101
61	MP0001661_extended_life_span	1.12127434
62	MP0005075_abnormal_melanosome_morpholog	1.10989960
63	MP0001845_abnormal_inflammatory_respons	1.10058853
64	MP0000858_altered_metastatic_potential	1.09930254
65	MP0008469_abnormal_protein_level	1.07465439
66	MP0000703_abnormal_thymus_morphology	1.07374952
67	MP0001881_abnormal_mammary_gland	1.06554856
68	MP0003950_abnormal_plasma_membrane	1.05897533
69	MP0009697_abnormal_copulation	1.05303637
70	MP0000343_altered_response_to	1.03755193
71	MP0005501_abnormal_skin_physiology	1.03214091
72	MP0000689_abnormal_spleen_morphology	1.00714448
73	MP0000371_diluted_coat_color	0.98494471
74	MP0000313_abnormal_cell_death	0.97032247
75	MP0005410_abnormal_fertilization	0.96338698
76	MP0005319_abnormal_enzyme/_coenzyme	0.93550350
77	MP0001727_abnormal_embryo_implantation	0.93260604
78	MP0001764_abnormal_homeostasis	0.92821614
79	MP0002405_respiratory_system_inflammati	0.92238013
80	MP0000678_abnormal_parathyroid_gland	0.91029958
81	MP0003699_abnormal_female_reproductive	0.89493753
82	MP0005394_taste/olfaction_phenotype	0.89367738
83	MP0005499_abnormal_olfactory_system	0.89367738
84	MP0004808_abnormal_hematopoietic_stem	0.89329180
85	MP0001919_abnormal_reproductive_system	0.89135293
86	MP0010307_abnormal_tumor_latency	0.88384450
87	MP0003075_altered_response_to	0.88279718
88	MP0001929_abnormal_gametogenesis	0.88101091
89	MP0001545_abnormal_hematopoietic_system	0.87433586
90	MP0005397_hematopoietic_system_phenotyp	0.87433586
91	MP0002210_abnormal_sex_determination	0.86943035
92	MP0003656_abnormal_erythrocyte_physiolo	0.86766365
93	MP0005266_abnormal_metabolism	0.86538718
94	MP0005389_reproductive_system_phenotype	0.86512892
95	MP0000350_abnormal_cell_proliferation	0.82840387
96	MP0010155_abnormal_intestine_physiology	0.81757372
97	MP0000490_abnormal_crypts_of	0.78246951
98	MP0001730_embryonic_growth_arrest	0.78058741
99	MP0002160_abnormal_reproductive_system	0.77700124
100	MP0003646_muscle_fatigue	0.76848568

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.45713054
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.79542712
3	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.60599585
4	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.60599585
5	Rough bone trabeculation (HP:0100670)	3.59997959
6	Chromsome breakage (HP:0040012)	3.54401287
7	Oral leukoplakia (HP:0002745)	3.53872404
8	Acute necrotizing encephalopathy (HP:0006965)	3.41365258
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37184170
10	Reticulocytopenia (HP:0001896)	3.34932314
11	Hypokinesia (HP:0002375)	3.09954705
12	Mitochondrial inheritance (HP:0001427)	3.06611201
13	Increased IgM level (HP:0003496)	2.96551885
14	Acute encephalopathy (HP:0006846)	2.94671836
15	Renal Fanconi syndrome (HP:0001994)	2.92358286
16	Abnormal trabecular bone morphology (HP:0100671)	2.85755000
17	Reduced antithrombin III activity (HP:0001976)	2.84603589
18	Type I transferrin isoform profile (HP:0003642)	2.83741203
19	Autoimmune thrombocytopenia (HP:0001973)	2.81507387
20	Autoimmune hemolytic anemia (HP:0001890)	2.79911354
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.79042489
22	Increased CSF lactate (HP:0002490)	2.78114903
23	Ureteral duplication (HP:0000073)	2.68319629
24	Hypergonadotropic hypogonadism (HP:0000815)	2.67583870
25	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.64869707
26	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.64700210
27	Microretrognathia (HP:0000308)	2.64201869
28	Lipid accumulation in hepatocytes (HP:0006561)	2.63696232
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.63624325
30	Pancytopenia (HP:0001876)	2.62606334
31	Progressive macrocephaly (HP:0004481)	2.62261095
32	3-Methylglutaconic aciduria (HP:0003535)	2.60304169
33	Abnormal protein glycosylation (HP:0012346)	2.55240480
34	Abnormal glycosylation (HP:0012345)	2.55240480
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.55240480
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.55240480
37	Increased intramyocellular lipid droplets (HP:0012240)	2.55179434
38	Increased hepatocellular lipid droplets (HP:0006565)	2.55021066
39	Generalized aminoaciduria (HP:0002909)	2.53641634
40	Increased muscle lipid content (HP:0009058)	2.52495511
41	Granulocytopenia (HP:0001913)	2.48053714
42	Abnormality of pyrimidine metabolism (HP:0004353)	2.47561311
43	Ragged-red muscle fibers (HP:0003200)	2.46434850
44	Eosinophilia (HP:0001880)	2.45772931
45	Hepatic necrosis (HP:0002605)	2.37253917
46	Lactic acidosis (HP:0003128)	2.36601591
47	Progressive muscle weakness (HP:0003323)	2.31476697
48	Reduced subcutaneous adipose tissue (HP:0003758)	2.30048176
49	Increased serum lactate (HP:0002151)	2.26719847
50	Duplicated collecting system (HP:0000081)	2.24392512
51	Abnormality of placental membranes (HP:0011409)	2.23539272
52	Amniotic constriction ring (HP:0009775)	2.23539272
53	Hepatocellular necrosis (HP:0001404)	2.23000184
54	Abnormality of T cell physiology (HP:0011840)	2.22784249
55	Nausea (HP:0002018)	2.21864417
56	Abnormality of liposaccharide metabolism (HP:0010968)	2.21669613
57	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.21669613
58	Abnormality of glycolipid metabolism (HP:0010969)	2.21669613
59	Abnormality of DNA repair (HP:0003254)	2.21126577
60	Self-mutilation (HP:0000742)	2.18998308
61	Respiratory difficulties (HP:0002880)	2.18003722
62	Exercise intolerance (HP:0003546)	2.17515556
63	Cerebral edema (HP:0002181)	2.16114363
64	Abnormality of the umbilical cord (HP:0010881)	2.15602500
65	Neutropenia (HP:0001875)	2.14730475
66	Abnormality of the preputium (HP:0100587)	2.14386227
67	Abnormality of B cell number (HP:0010975)	2.14310607
68	Exertional dyspnea (HP:0002875)	2.14018146
69	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.13569837
70	Cholecystitis (HP:0001082)	2.12435632
71	Abnormal gallbladder physiology (HP:0012438)	2.12435632
72	Abnormality of T cells (HP:0002843)	2.11500654
73	Recurrent viral infections (HP:0004429)	2.10437426
74	Premature ovarian failure (HP:0008209)	2.08927310
75	Increased serum ferritin (HP:0003281)	2.05961656
76	Abnormality of the renal collecting system (HP:0004742)	2.01396009
77	Premature graying of hair (HP:0002216)	1.96779781
78	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.96214966
79	Thrombocytosis (HP:0001894)	1.95574408
80	Multiple enchondromatosis (HP:0005701)	1.92852911
81	Vacuolated lymphocytes (HP:0001922)	1.92849358
82	Abnormalities of placenta or umbilical cord (HP:0001194)	1.90422241
83	Cellular immunodeficiency (HP:0005374)	1.90089512
84	Respiratory failure (HP:0002878)	1.90020948
85	Loss of speech (HP:0002371)	1.88211069
86	Entropion (HP:0000621)	1.87565787
87	Abnormal spermatogenesis (HP:0008669)	1.87179821
88	Horseshoe kidney (HP:0000085)	1.85833497
89	Abnormality of fatty-acid metabolism (HP:0004359)	1.85181610
90	Progressive neurologic deterioration (HP:0002344)	1.84249802
91	Abnormality of the phalanges of the hallux (HP:0010057)	1.83169957
92	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.81980926
93	Petechiae (HP:0000967)	1.81666243
94	Hypertensive crisis (HP:0100735)	1.80082384
95	Abnormality of the prostate (HP:0008775)	1.80015046
96	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.79692338
97	Absent thumb (HP:0009777)	1.78065649
98	Increased serum pyruvate (HP:0003542)	1.77398109
99	Abnormality of eosinophils (HP:0001879)	1.76639857
100	Paralysis (HP:0003470)	1.76506293

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.27640619
2	BUB1	4.01183361
3	TAOK3	3.72716915
4	TXK	3.66135277
5	MAP4K1	2.99466462
6	IRAK3	2.52672093
7	STK16	2.24943666
8	BCKDK	2.24340884
9	TESK2	2.13530553
10	VRK2	2.11661684
11	TLK1	1.93274002
12	MST4	1.89959886
13	ARAF	1.89797299
14	ZAK	1.67471006
15	MARK3	1.62961717
16	TESK1	1.62917176
17	EIF2AK3	1.53261630
18	CDK19	1.48032913
19	AURKA	1.43460831
20	KDR	1.33465419
21	TAOK2	1.29772675
22	CDK8	1.29275944
23	RIPK4	1.27984069
24	BRSK1	1.20981410
25	BRAF	1.19977263
26	PDK2	1.17827630
27	PIM2	1.16604037
28	IKBKB	1.12583811
29	NEK2	1.10077809
30	MAPKAPK3	1.08359224
31	TBK1	1.06519716
32	MAP3K3	1.06474090
33	BMPR2	1.05986563
34	MAP3K13	1.05148369
35	CDC7	0.98205139
36	NUAK1	0.97751800
37	AURKB	0.96076472
38	PLK1	0.94458356
39	PBK	0.93570131
40	ZAP70	0.91938290
41	CDK7	0.91085720
42	NME1	0.90526383
43	MAPK11	0.88992399
44	BRSK2	0.88370846
45	ILK	0.87351162
46	IRAK2	0.86005821
47	CDK9	0.85559023
48	TTK	0.85066902
49	ABL2	0.83957039
50	ICK	0.80338252
51	MAP2K3	0.78404615
52	MOS	0.77021076
53	ERN1	0.76114708
54	CHEK2	0.74385960
55	NEK1	0.73782337
56	STK24	0.73402399
57	PAK4	0.72256180
58	CDK3	0.71590078
59	SRPK1	0.71543544
60	MYLK	0.71385068
61	WEE1	0.71097192
62	MELK	0.68986738
63	PAK1	0.68878904
64	CDK4	0.68417333
65	MAP3K8	0.67300027
66	VRK1	0.67115868
67	TYK2	0.66238267
68	ATR	0.65447444
69	IKBKE	0.64430205
70	LRRK2	0.63850127
71	PRKCI	0.63385101
72	GRK6	0.63215533
73	CSNK1G1	0.61343061
74	RPS6KB2	0.60639856
75	DAPK3	0.60582723
76	MST1R	0.59207782
77	CSNK1G3	0.58379931
78	STK10	0.56069576
79	IRAK4	0.54864156
80	BTK	0.54288099
81	PRPF4B	0.52907532
82	TRIB3	0.52551185
83	SMG1	0.51395757
84	MAPKAPK5	0.51194875
85	LIMK1	0.50294408
86	CHEK1	0.48965557
87	GRK1	0.48721971
88	EIF2AK1	0.47702362
89	MAP3K9	0.47620158
90	MAP3K11	0.44319954
91	PINK1	0.44257164
92	MATK	0.44178990
93	LYN	0.43011918
94	MAPKAPK2	0.42771967
95	CDK12	0.42516689
96	SYK	0.42272562
97	AKT2	0.40596719
98	CSNK2A2	0.39447277
99	PKN1	0.38613611
100	MAP3K10	0.36175030

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.70036731
2	Ribosome_Homo sapiens_hsa03010	3.62009043
3	DNA replication_Homo sapiens_hsa03030	3.24608217
4	Mismatch repair_Homo sapiens_hsa03430	2.90030421
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.70973652
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.47086346
7	RNA polymerase_Homo sapiens_hsa03020	2.46077941
8	Base excision repair_Homo sapiens_hsa03410	2.27980993
9	Pyrimidine metabolism_Homo sapiens_hsa00240	2.26747336
10	Parkinsons disease_Homo sapiens_hsa05012	2.23789764
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.09196066
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.99445642
13	Homologous recombination_Homo sapiens_hsa03440	1.98484907
14	Sulfur relay system_Homo sapiens_hsa04122	1.84988550
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.66418589
16	Asthma_Homo sapiens_hsa05310	1.60919678
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59295439
18	Allograft rejection_Homo sapiens_hsa05330	1.58245312
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.56626928
20	Protein export_Homo sapiens_hsa03060	1.54881453
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54456411
22	Huntingtons disease_Homo sapiens_hsa05016	1.52287082
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.48726245
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46308385
25	Basal transcription factors_Homo sapiens_hsa03022	1.43103235
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.42191400
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39944267
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.37704697
29	Folate biosynthesis_Homo sapiens_hsa00790	1.36931721
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35584934
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.32474277
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.32136305
33	Cell cycle_Homo sapiens_hsa04110	1.30162519
34	Alzheimers disease_Homo sapiens_hsa05010	1.29986877
35	Glutathione metabolism_Homo sapiens_hsa00480	1.23516168
36	One carbon pool by folate_Homo sapiens_hsa00670	1.21550842
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18206821
38	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.17525420
39	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.15608795
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.15105238
41	Sulfur metabolism_Homo sapiens_hsa00920	1.11405358
42	RNA transport_Homo sapiens_hsa03013	1.09806153
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09779755
44	p53 signaling pathway_Homo sapiens_hsa04115	1.08328233
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.08241264
46	Purine metabolism_Homo sapiens_hsa00230	1.06073363
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.06072496
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.03119593
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99485437
50	Herpes simplex infection_Homo sapiens_hsa05168	0.94463652
51	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.92287991
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84247805
53	Antigen processing and presentation_Homo sapiens_hsa04612	0.83869866
54	Spliceosome_Homo sapiens_hsa03040	0.83674098
55	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.80187126
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78317973
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.77989231
58	RNA degradation_Homo sapiens_hsa03018	0.75888975
59	Carbon metabolism_Homo sapiens_hsa01200	0.74175808
60	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.73843267
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.73335437
62	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.71212687
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.71066993
64	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70547023
65	Other glycan degradation_Homo sapiens_hsa00511	0.69417913
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68577753
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68357039
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65340809
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65301786
70	Lysosome_Homo sapiens_hsa04142	0.63949876
71	Pyruvate metabolism_Homo sapiens_hsa00620	0.62625541
72	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.61066133
73	Viral myocarditis_Homo sapiens_hsa05416	0.60442457
74	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.59682274
75	Fatty acid elongation_Homo sapiens_hsa00062	0.58200124
76	Metabolic pathways_Homo sapiens_hsa01100	0.57788351
77	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57340456
78	Pentose phosphate pathway_Homo sapiens_hsa00030	0.56608029
79	Influenza A_Homo sapiens_hsa05164	0.56014612
80	Measles_Homo sapiens_hsa05162	0.54873316
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.54831400
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.53976389
83	Shigellosis_Homo sapiens_hsa05131	0.53720098
84	HTLV-I infection_Homo sapiens_hsa05166	0.53542415
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.50687242
86	Apoptosis_Homo sapiens_hsa04210	0.49516429
87	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45559140
88	Viral carcinogenesis_Homo sapiens_hsa05203	0.41618957
89	Leishmaniasis_Homo sapiens_hsa05140	0.41232691
90	Hepatitis B_Homo sapiens_hsa05161	0.40889006
91	Bladder cancer_Homo sapiens_hsa05219	0.40489466
92	Salmonella infection_Homo sapiens_hsa05132	0.40224890
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39954996
94	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.39403213
95	Tuberculosis_Homo sapiens_hsa05152	0.38859632
96	Galactose metabolism_Homo sapiens_hsa00052	0.36290970
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35973910
98	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.34629317
99	Malaria_Homo sapiens_hsa05144	0.33769177
100	Oocyte meiosis_Homo sapiens_hsa04114	0.33494217

OR7E38P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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