OR7E43P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.76010479
2seminiferous tubule development (GO:0072520)9.55715693
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.11406526
4cAMP biosynthetic process (GO:0006171)8.76041463
5detection of chemical stimulus involved in sensory perception (GO:0050907)8.55017383
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.32089476
7enteric nervous system development (GO:0048484)7.88704459
8regulation of protein sumoylation (GO:0033233)7.59048772
9dendritic spine morphogenesis (GO:0060997)7.16828899
10positive regulation of mitochondrial fission (GO:0090141)7.09421901
11synaptic transmission, dopaminergic (GO:0001963)7.05970146
12righting reflex (GO:0060013)6.82085149
13heterotypic cell-cell adhesion (GO:0034113)6.45642858
14positive regulation of T-helper 1 type immune response (GO:0002827)6.27774646
15detection of chemical stimulus (GO:0009593)6.12595228
16arachidonic acid secretion (GO:0050482)6.08401609
17icosanoid secretion (GO:0032309)6.08401609
18endothelial cell differentiation (GO:0045446)5.96606331
19hepatocyte apoptotic process (GO:0097284)5.93996272
20phosphatidylinositol acyl-chain remodeling (GO:0036149)5.77663669
21positive regulation of T-helper cell differentiation (GO:0045624)5.71947701
22phosphatidylserine acyl-chain remodeling (GO:0036150)5.27897378
23regulation of mitochondrial fission (GO:0090140)5.25061136
24drug transmembrane transport (GO:0006855)5.19169570
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.05804419
26icosanoid transport (GO:0071715)5.03601101
27fatty acid derivative transport (GO:1901571)5.03601101
28neuronal ion channel clustering (GO:0045161)4.90926426
29neural tube formation (GO:0001841)4.83920037
30negative regulation of alpha-beta T cell activation (GO:0046636)4.80916767
31hyaluronan catabolic process (GO:0030214)4.74225965
32chemosensory behavior (GO:0007635)4.73586367
33embryonic digestive tract morphogenesis (GO:0048557)4.52685228
34regulation of T-helper 1 type immune response (GO:0002825)4.49827015
35cilium or flagellum-dependent cell motility (GO:0001539)4.49615041
36nephron epithelium morphogenesis (GO:0072088)4.47264136
37nephron tubule morphogenesis (GO:0072078)4.47264136
38retina layer formation (GO:0010842)4.43777565
39cyclic purine nucleotide metabolic process (GO:0052652)4.35951389
40positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.33743059
41vocalization behavior (GO:0071625)4.29117123
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.27949922
43ATP hydrolysis coupled proton transport (GO:0015991)4.27949922
44positive regulation of membrane potential (GO:0045838)4.25495140
45attachment of spindle microtubules to kinetochore (GO:0008608)4.24698009
46mitochondrial fusion (GO:0008053)4.23014420
47cyclic nucleotide biosynthetic process (GO:0009190)4.22427521
48regulation of cAMP-mediated signaling (GO:0043949)4.15051012
49regulation of T-helper cell differentiation (GO:0045622)4.13631444
50response to dietary excess (GO:0002021)4.13459895
51negative regulation of actin filament bundle assembly (GO:0032232)4.13321140
52cellular response to glucagon stimulus (GO:0071377)4.12506055
53regulation of type 2 immune response (GO:0002828)4.08262344
54water transport (GO:0006833)4.08167883
55protein localization to synapse (GO:0035418)4.06585615
56dendritic spine organization (GO:0097061)4.05149918
57cAMP metabolic process (GO:0046058)3.96575914
58monoamine transport (GO:0015844)3.89296029
59positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.81043936
60negative regulation of T cell differentiation (GO:0045581)3.78556904
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.77789464
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.77745686
63cellular zinc ion homeostasis (GO:0006882)3.76776481
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.72255299
65fluid transport (GO:0042044)3.64037233
66positive regulation of protein targeting to membrane (GO:0090314)3.60307894
67leukotriene biosynthetic process (GO:0019370)3.60062430
68drug transport (GO:0015893)3.57193541
69cellular response to ATP (GO:0071318)3.54275655
70sulfur amino acid catabolic process (GO:0000098)3.51304082
71positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.46684791
72pre-miRNA processing (GO:0031054)3.39762430
73sequestering of metal ion (GO:0051238)3.38901729
74left/right axis specification (GO:0070986)3.37672752
75negative regulation of homotypic cell-cell adhesion (GO:0034111)3.32119076
76phosphatidylcholine acyl-chain remodeling (GO:0036151)3.27619841
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25366813
78positive regulation of alpha-beta T cell differentiation (GO:0046638)3.24334821
79regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.24216732
80renal tubule morphogenesis (GO:0061333)3.20454026
81negative regulation of astrocyte differentiation (GO:0048712)3.19725302
82negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.15901067
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15372286
84adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.15313418
85response to glucagon (GO:0033762)3.06877481
86positive regulation of steroid hormone secretion (GO:2000833)3.06329236
87neurofilament cytoskeleton organization (GO:0060052)3.05558537
88positive regulation of dendritic spine development (GO:0060999)3.04682556
89neuromuscular process controlling posture (GO:0050884)3.04061955
90prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.02031594
91tooth mineralization (GO:0034505)14.3380288
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6778525
93positive regulation of protein sumoylation (GO:0033235)12.0844990
94negative regulation of T-helper cell differentiation (GO:0045623)11.3500359
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.3500359
96protein K11-linked deubiquitination (GO:0035871)10.6382765
97regulation of T-helper 1 cell differentiation (GO:0045625)10.2387808
98activation of protein kinase A activity (GO:0034199)10.0565920
99regulation of T-helper 2 cell differentiation (GO:0045628)10.0465321
100negative regulation of type 2 immune response (GO:0002829)10.0224335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.83926648
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.32369087
3AR_21572438_ChIP-Seq_LNCaP_Human5.06509558
4IGF1R_20145208_ChIP-Seq_DFB_Human4.79493943
5VDR_22108803_ChIP-Seq_LS180_Human4.24208049
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.40598991
7TP53_16413492_ChIP-PET_HCT116_Human2.18260692
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01935723
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7063946
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.96023161
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91812793
12ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89727422
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79101398
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79101398
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71319808
16GATA1_19941826_ChIP-Seq_K562_Human1.66774279
17DROSHA_22980978_ChIP-Seq_HELA_Human1.62370141
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61211536
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.58383054
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.54446688
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53578771
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45272775
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44601788
24EGR1_19032775_ChIP-ChIP_M12_Human1.43939305
25SMAD3_21741376_ChIP-Seq_HESCs_Human1.43205192
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42794022
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41711978
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41628045
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35127883
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.35010281
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.32881560
32RNF2_27304074_Chip-Seq_NSC_Mouse1.32869763
33RXR_22108803_ChIP-Seq_LS180_Human1.23521907
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.22383850
35TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.20746824
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.20380416
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17561541
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16226902
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15579048
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.15340827
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12096011
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.12077070
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11989269
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11884318
45GBX2_23144817_ChIP-Seq_PC3_Human1.11224924
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11027805
47EZH2_22144423_ChIP-Seq_EOC_Human1.09691186
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07482004
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07120284
50HNFA_21074721_ChIP-Seq_CACO-2_Human1.05879943
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05603229
52SOX2_18555785_Chip-Seq_ESCs_Mouse1.05220404
53ER_23166858_ChIP-Seq_MCF-7_Human1.04160066
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03436965
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03334077
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02958949
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.02314694
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01526867
59GATA6_21074721_ChIP-Seq_CACO-2_Human1.00548566
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99781380
61CMYC_18555785_Chip-Seq_ESCs_Mouse0.96494777
62SMAD4_21741376_ChIP-Seq_HESCs_Human0.95351163
63TBL1_22424771_ChIP-Seq_293T_Human0.95085803
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94763537
65ZNF274_21170338_ChIP-Seq_K562_Hela0.94648314
66ARNT_22903824_ChIP-Seq_MCF-7_Human0.94461520
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94199331
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93162237
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93122361
70PHF8_20622853_ChIP-Seq_HELA_Human0.92585653
71STAT3_23295773_ChIP-Seq_U87_Human0.91449045
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90444333
73CJUN_26792858_Chip-Seq_BT549_Human0.88919666
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88556868
75ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88072248
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87380130
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87028332
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86957563
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86712417
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85754868
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85632422
82SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85084002
83REST_21632747_ChIP-Seq_MESCs_Mouse0.84889913
84EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84690306
85RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84690306
86BCAT_22108803_ChIP-Seq_LS180_Human0.84529051
87CTCF_27219007_Chip-Seq_Bcells_Human0.82780646
88E2F1_18555785_Chip-Seq_ESCs_Mouse0.81871143
89NANOG_16518401_ChIP-PET_MESCs_Mouse0.81838080
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80929008
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.79815561
92GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79769205
93NMYC_18555785_Chip-Seq_ESCs_Mouse0.79742973
94KLF4_18555785_Chip-Seq_ESCs_Mouse0.79716437
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79555398
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77651759
97CBP_20019798_ChIP-Seq_JUKART_Human0.76934939
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76934939
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.75963317
100P53_22387025_ChIP-Seq_ESCs_Mouse0.74998091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.77776658
2MP0004130_abnormal_muscle_cell5.13767272
3MP0004264_abnormal_extraembryonic_tissu3.92925647
4MP0003252_abnormal_bile_duct3.53434980
5MP0004133_heterotaxia3.01917603
6MP0002928_abnormal_bile_duct2.65341911
7MP0006072_abnormal_retinal_apoptosis2.52904407
8MP0005448_abnormal_energy_balance2.45077358
9MP0002751_abnormal_autonomic_nervous2.22025940
10MP0005408_hypopigmentation2.12392755
11MP0004272_abnormal_basement_membrane2.08600191
12MP0001270_distended_abdomen2.00090758
13MP0005084_abnormal_gallbladder_morpholo12.4861390
14MP0003329_amyloid_beta_deposits1.97983675
15MP0003943_abnormal_hepatobiliary_system1.73224772
16MP0005379_endocrine/exocrine_gland_phen1.66998614
17MP0005220_abnormal_exocrine_pancreas1.63723884
18MP0001529_abnormal_vocalization1.56944484
19MP0005165_increased_susceptibility_to1.54184111
20MP0001958_emphysema1.39951634
21MP0009764_decreased_sensitivity_to1.37070482
22MP0003718_maternal_effect1.23862906
23MP0000604_amyloidosis1.23376255
24MP0005646_abnormal_pituitary_gland1.15975384
25MP0000470_abnormal_stomach_morphology1.06201107
26MP0001944_abnormal_pancreas_morphology1.04821408
27MP0002572_abnormal_emotion/affect_behav1.01522257
28MP0001905_abnormal_dopamine_level1.00373190
29MP0000465_gastrointestinal_hemorrhage0.99120128
30MP0003638_abnormal_response/metabolism_0.94076518
31MP0002909_abnormal_adrenal_gland0.92863320
32MP0008569_lethality_at_weaning0.89806424
33MP0004019_abnormal_vitamin_homeostasis0.86988538
34MP0000371_diluted_coat_color0.83969388
35MP0005164_abnormal_response_to0.82976048
36MP0008469_abnormal_protein_level0.76792226
37MP0005253_abnormal_eye_physiology0.76094855
38MP0002693_abnormal_pancreas_physiology0.74367350
39MP0008875_abnormal_xenobiotic_pharmacok0.73439481
40MP0001800_abnormal_humoral_immune0.73199235
41MP0001915_intracranial_hemorrhage0.72687436
42MP0000609_abnormal_liver_physiology0.70106533
43MP0002405_respiratory_system_inflammati0.69392831
44MP0003121_genomic_imprinting0.68155195
45MP0002098_abnormal_vibrissa_morphology0.67276894
46MP0003866_abnormal_defecation0.65614873
47MP0002136_abnormal_kidney_physiology0.64216544
48MP0002078_abnormal_glucose_homeostasis0.64166432
49MP0003953_abnormal_hormone_level0.63652342
50MP0001533_abnormal_skeleton_physiology0.57441500
51MP0001851_eye_inflammation0.56883929
52MP0000703_abnormal_thymus_morphology0.56685540
53MP0001790_abnormal_immune_system0.56366672
54MP0005387_immune_system_phenotype0.56366672
55MP0001986_abnormal_taste_sensitivity0.52665126
56MP0005551_abnormal_eye_electrophysiolog0.51846390
57MP0002998_abnormal_bone_remodeling0.49728988
58MP0003283_abnormal_digestive_organ0.47977497
59MP0009642_abnormal_blood_homeostasis0.47396073
60MP0001845_abnormal_inflammatory_respons0.47035536
61MP0004947_skin_inflammation0.45805196
62MP0003195_calcinosis0.44376091
63MP0003136_yellow_coat_color0.43669285
64MP0004484_altered_response_of0.43010576
65MP0005334_abnormal_fat_pad0.42144368
66MP0000477_abnormal_intestine_morphology0.39649279
67MP0002722_abnormal_immune_system0.39586739
68MP0002882_abnormal_neuron_morphology0.35758055
69MP0000759_abnormal_skeletal_muscle0.35754453
70MP0005365_abnormal_bile_salt0.35614286
71MP0002735_abnormal_chemical_nociception0.35323469
72MP0000598_abnormal_liver_morphology0.34872518
73MP0008004_abnormal_stomach_pH0.34420243
74MP0005423_abnormal_somatic_nervous0.34354366
75MP0009053_abnormal_anal_canal0.34014147
76MP0000920_abnormal_myelination0.33713016
77MP0002429_abnormal_blood_cell0.33426647
78MP0002822_catalepsy0.33421514
79MP0001299_abnormal_eye_distance/0.33271531
80MP0002419_abnormal_innate_immunity0.32971527
81MP0002229_neurodegeneration0.31566279
82MP0001501_abnormal_sleep_pattern0.30953888
83MP0002452_abnormal_antigen_presenting0.30475307
84MP0005390_skeleton_phenotype0.29992799
85MP0001175_abnormal_lung_morphology0.29653398
86MP0002277_abnormal_respiratory_mucosa0.29032407
87MP0009931_abnormal_skin_appearance0.28539670
88MP0003880_abnormal_central_pattern0.28311525
89MP0002420_abnormal_adaptive_immunity0.26913312
90MP0000716_abnormal_immune_system0.26774592
91MP0001819_abnormal_immune_cell0.26541632
92MP0005391_vision/eye_phenotype0.26405790
93MP0003011_delayed_dark_adaptation0.25613414
94MP0002723_abnormal_immune_serum0.24592743
95MP0002398_abnormal_bone_marrow0.24333472
96MP0003878_abnormal_ear_physiology0.23542528
97MP0005377_hearing/vestibular/ear_phenot0.23542528
98MP0002066_abnormal_motor_capabilities/c0.23361264
99MP0005395_other_phenotype0.23047565
100MP0002837_dystrophic_cardiac_calcinosis0.22913915

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.86220427
2Abnormality of dental color (HP:0011073)8.19457654
3Abnormality of renal resorption (HP:0011038)8.04813257
4Polyuria (HP:0000103)7.76209513
5Osteomalacia (HP:0002749)7.74352655
6Abnormality of the dental pulp (HP:0006479)7.57034435
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.80151351
8Abnormal urine output (HP:0012590)6.63083947
9Abnormality of renal excretion (HP:0011036)5.77300886
10Round ear (HP:0100830)5.46801640
11Chronic bronchitis (HP:0004469)5.10549651
12Volvulus (HP:0002580)4.26704414
13IgM deficiency (HP:0002850)4.06115656
14Lip pit (HP:0100267)4.05605068
15Molar tooth sign on MRI (HP:0002419)4.04616701
16Abnormality of midbrain morphology (HP:0002418)4.04616701
17Autoimmune thrombocytopenia (HP:0001973)4.01373632
18Toxemia of pregnancy (HP:0100603)3.96508452
19Nephrocalcinosis (HP:0000121)3.75112072
20Esophageal varix (HP:0002040)3.72819617
21Depressed nasal tip (HP:0000437)3.72418960
22Large earlobe (HP:0009748)3.56124295
23Lipoatrophy (HP:0100578)3.45178555
24Tachypnea (HP:0002789)3.35826603
25Abnormal respiratory motile cilium physiology (HP:0012261)3.33119925
26Drooling (HP:0002307)3.28081839
27Intestinal fistula (HP:0100819)3.24859003
28Rhinitis (HP:0012384)3.23041018
29Excessive salivation (HP:0003781)3.13899018
30Sparse lateral eyebrow (HP:0005338)3.06651483
31Hypoparathyroidism (HP:0000829)3.02909179
32Thick eyebrow (HP:0000574)2.87974928
33Panhypogammaglobulinemia (HP:0003139)2.84797240
34Hyperphosphaturia (HP:0003109)2.84218919
35Personality changes (HP:0000751)2.72029248
36Nephronophthisis (HP:0000090)2.62340976
37Short 5th finger (HP:0009237)2.55156150
38Dilated cardiomyopathy (HP:0001644)2.51465084
39Petechiae (HP:0000967)2.51417123
40Ureteral stenosis (HP:0000071)2.45200006
41Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.43626255
42Abnormality of the fingertips (HP:0001211)2.38474485
43Abnormal urine phosphate concentration (HP:0012599)2.36879107
44Hepatitis (HP:0012115)2.36599725
45Abnormality of urine glucose concentration (HP:0011016)2.32646161
46Glycosuria (HP:0003076)2.32646161
47Gingival overgrowth (HP:0000212)2.29521968
48Bronchitis (HP:0012387)2.27877119
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.26771152
50Nephropathy (HP:0000112)2.26133707
51Recurrent cutaneous fungal infections (HP:0011370)2.25806678
52Chronic mucocutaneous candidiasis (HP:0002728)2.25806678
53Abnormality of transition element cation homeostasis (HP:0011030)2.25572008
54Ureteral obstruction (HP:0006000)2.23935897
55Inability to walk (HP:0002540)2.22084974
56Periauricular skin pits (HP:0100277)2.20312448
57Preauricular pit (HP:0004467)2.20312448
58Prominent supraorbital ridges (HP:0000336)2.17413584
59Anal stenosis (HP:0002025)2.15424856
60Abnormality of the renal medulla (HP:0100957)2.12199852
61Hypercalciuria (HP:0002150)2.09964177
62Striae distensae (HP:0001065)2.09261123
63Sudden cardiac death (HP:0001645)2.07661903
64Colitis (HP:0002583)2.06155650
65Recurrent otitis media (HP:0000403)2.05387853
66Abnormality of salivation (HP:0100755)2.01683530
67Overgrowth (HP:0001548)12.1424299
68Amelogenesis imperfecta (HP:0000705)11.6567800
69Decreased muscle mass (HP:0003199)1.97623258
70Agammaglobulinemia (HP:0004432)1.96959656
71Ectopic kidney (HP:0000086)1.94493802
72Chorioretinal coloboma (HP:0000567)1.90237987
73Delayed eruption of teeth (HP:0000684)1.88636789
74Truncal ataxia (HP:0002078)1.81562871
75Chondrocalcinosis (HP:0000934)1.81345788
76Preauricular skin tag (HP:0000384)1.79972375
77Abnormality of Sharpey fibers (HP:0100685)1.76753130
78Stage 5 chronic kidney disease (HP:0003774)1.72941021
79Small hand (HP:0200055)1.70849289
80Renal tubular dysfunction (HP:0000124)1.70417457
81Limited elbow extension (HP:0001377)1.66769332
82Oculomotor apraxia (HP:0000657)1.60734305
83Palmoplantar keratoderma (HP:0000982)1.59017895
84Ectropion (HP:0000656)1.56892063
85Highly arched eyebrow (HP:0002553)1.55578770
86Skin tags (HP:0010609)1.54067558
87Torticollis (HP:0000473)1.52702403
88Skin pits (HP:0100276)1.52496344
89Bronchiectasis (HP:0002110)1.50228997
90Villous atrophy (HP:0011473)1.49036958
91Abnormality of small intestinal villus morphology (HP:0011472)1.49036958
92Prenatal maternal abnormality (HP:0002686)1.46883635
93Blepharitis (HP:0000498)1.46009175
94Polyneuropathy (HP:0001271)1.40877894
95Proximal placement of thumb (HP:0009623)1.34550249
96Abnormality of sodium homeostasis (HP:0010931)1.33356513
97Mask-like facies (HP:0000298)1.32530015
98Viral hepatitis (HP:0006562)1.29063199
99Aplasia/Hypoplasia of the earlobes (HP:0009906)1.27075592
100Inflammation of the large intestine (HP:0002037)1.25444685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.45245541
2BLK4.17043819
3STK34.01802524
4RIPK43.13351607
5BMPR22.45227095
6INSRR2.34418860
7CDC42BPA2.06651445
8NTRK214.0563234
9HIPK21.25862951
10MUSK0.94650232
11FGFR10.86781379
12ROCK20.73457270
13SYK0.64056027
14SRC0.61404735
15OBSCN0.61133215
16PRKCQ0.56825588
17PRKAA10.53984390
18ROCK10.52612496
19WNK30.50923084
20GRK10.50247786
21MAP4K20.48303712
22PRKACG0.44523052
23ADRBK20.44457280
24GRK70.43892384
25MAPK150.43308931
26TIE10.40322430
27TXK0.38760736
28ABL10.38725947
29PRKACA0.38391595
30PRKACB0.35000806
31CAMK2A0.33088433
32ERBB40.32465835
33PLK10.32084420
34SRPK10.30761084
35WNK40.30158444
36NTRK10.29938876
37OXSR10.27154352
38ADRBK10.26225306
39PLK40.25792251
40EPHA40.24489865
41PIK3CG0.24442546
42STK390.24441628
43KIT0.23756504
44PIK3CA0.23583024
45MAPK140.22504088
46PRKCA0.22410104
47MATK0.22278465
48LYN0.21571796
49GRK50.21185829
50GSK3B0.20874622
51RPS6KA30.17643900
52PRKCB0.17461532
53MET0.16822192
54CSNK1A10.16013801
55TEC0.15816172
56PIM20.15707595
57ITK0.15542634
58CHUK0.15338800
59IRAK40.14912209
60GRK60.14868492
61TLK10.14355602
62CDK10.13838945
63FYN0.13819535
64MST1R0.13267505
65PRKCD0.13067674
66LCK0.12892516
67KDR0.12841194
68LMTK20.12836744
69TTN0.12618596
70TNK20.12320202
71DDR20.11704532
72IGF1R0.11077719
73PHKG20.10596707
74PHKG10.10596707
75PRKDC0.09751287
76IRAK20.09573205
77PRKCG0.09527095
78MAP2K60.08970298
79MAPK90.08605358
80EPHA20.07933228
81EPHB20.07664481
82DAPK20.07488909
83EGFR0.07488690
84FLT30.06942875
85CSF1R0.06865882
86AKT10.06772042
87ABL20.06642297
88RPS6KA50.06413242
89PRKCE0.05806795
90LATS20.05293022
91WEE10.04861815
92CAMK2G0.04577786
93HCK0.04376148
94PINK10.04261925
95PASK0.04227572
96PKN10.04100158
97ERBB20.03811041
98INSR0.03175088
99BTK0.02285730
100PIM10.02190079

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.23444962
2Sulfur relay system_Homo sapiens_hsa041223.95482853
3Sulfur metabolism_Homo sapiens_hsa009203.54727879
4Ovarian steroidogenesis_Homo sapiens_hsa049133.38607255
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.33341852
6Linoleic acid metabolism_Homo sapiens_hsa005913.05844408
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.86205463
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.70728762
9Bile secretion_Homo sapiens_hsa049762.43821481
10Collecting duct acid secretion_Homo sapiens_hsa049662.43594277
11Vibrio cholerae infection_Homo sapiens_hsa051102.27588468
12Thyroid hormone synthesis_Homo sapiens_hsa049182.16903219
13Pancreatic secretion_Homo sapiens_hsa049722.16860000
14Fat digestion and absorption_Homo sapiens_hsa049752.11115605
15Gastric acid secretion_Homo sapiens_hsa049712.07857700
16Salivary secretion_Homo sapiens_hsa049702.06567075
17Synaptic vesicle cycle_Homo sapiens_hsa047211.95546257
18Cocaine addiction_Homo sapiens_hsa050301.92372317
19Circadian entrainment_Homo sapiens_hsa047131.82371956
20Taste transduction_Homo sapiens_hsa047421.78912546
21Insulin secretion_Homo sapiens_hsa049111.78838041
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78755627
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.73612553
24Ether lipid metabolism_Homo sapiens_hsa005651.72497525
25Glutamatergic synapse_Homo sapiens_hsa047241.70017837
26GABAergic synapse_Homo sapiens_hsa047271.66128262
27Morphine addiction_Homo sapiens_hsa050321.65830039
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.62627983
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61127624
30Dilated cardiomyopathy_Homo sapiens_hsa054141.60303252
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48257378
32Gap junction_Homo sapiens_hsa045401.45624224
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43096160
34Arachidonic acid metabolism_Homo sapiens_hsa005901.41860214
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40401675
36Amphetamine addiction_Homo sapiens_hsa050311.39494484
37GnRH signaling pathway_Homo sapiens_hsa049121.33083325
38Melanogenesis_Homo sapiens_hsa049161.30902013
39Cholinergic synapse_Homo sapiens_hsa047251.16575238
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16266389
41Oxytocin signaling pathway_Homo sapiens_hsa049211.15030826
42Platelet activation_Homo sapiens_hsa046111.12034628
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11869005
44Estrogen signaling pathway_Homo sapiens_hsa049151.05857784
45Calcium signaling pathway_Homo sapiens_hsa040201.04854130
46Circadian rhythm_Homo sapiens_hsa047100.97009649
47Dorso-ventral axis formation_Homo sapiens_hsa043200.87908817
48Pyruvate metabolism_Homo sapiens_hsa006200.85069512
49Oocyte meiosis_Homo sapiens_hsa041140.76670968
50Serotonergic synapse_Homo sapiens_hsa047260.75960991
51ECM-receptor interaction_Homo sapiens_hsa045120.72302691
52Chemokine signaling pathway_Homo sapiens_hsa040620.70455630
53RNA degradation_Homo sapiens_hsa030180.69623281
54Rheumatoid arthritis_Homo sapiens_hsa053230.63601369
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62702180
56Parkinsons disease_Homo sapiens_hsa050120.46227277
57cAMP signaling pathway_Homo sapiens_hsa040240.45437288
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.42983940
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.40200079
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37380584
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37317586
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37029366
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.36900352
64Alcoholism_Homo sapiens_hsa050340.36283931
65Retinol metabolism_Homo sapiens_hsa008300.35985030
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35387776
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33603222
68Oxidative phosphorylation_Homo sapiens_hsa001900.32079625
69Dopaminergic synapse_Homo sapiens_hsa047280.31616706
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.29525519
71Staphylococcus aureus infection_Homo sapiens_hsa051500.28742677
72Primary immunodeficiency_Homo sapiens_hsa053400.26290555
73Prion diseases_Homo sapiens_hsa050200.26120343
74Purine metabolism_Homo sapiens_hsa002300.24983416
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23151301
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20240371
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.20239516
78Rap1 signaling pathway_Homo sapiens_hsa040150.19618315
79Chemical carcinogenesis_Homo sapiens_hsa052040.18280206
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.16190997
81Hedgehog signaling pathway_Homo sapiens_hsa043400.15965440
82Glucagon signaling pathway_Homo sapiens_hsa049220.15385078
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15226679
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12188166
85Systemic lupus erythematosus_Homo sapiens_hsa053220.10821971
86Caffeine metabolism_Homo sapiens_hsa002320.09410822
87Ras signaling pathway_Homo sapiens_hsa040140.09285829
88Nicotine addiction_Homo sapiens_hsa050330.08882368
89Tuberculosis_Homo sapiens_hsa051520.08124943
90HTLV-I infection_Homo sapiens_hsa051660.07815350
91Phagosome_Homo sapiens_hsa041450.07120093
92Type I diabetes mellitus_Homo sapiens_hsa049400.06855287
93Phototransduction_Homo sapiens_hsa047440.04550888
94Leishmaniasis_Homo sapiens_hsa051400.03810321
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.03700532
96African trypanosomiasis_Homo sapiens_hsa051430.03276637
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.02047324
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.01936288
99Hematopoietic cell lineage_Homo sapiens_hsa046400.01680320
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.00285407

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