OR7E46P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activation of protein kinase A activity (GO:0034199)9.89141142
2regulation of T-helper 2 cell differentiation (GO:0045628)9.87526576
3negative regulation of type 2 immune response (GO:0002829)9.81071507
4seminiferous tubule development (GO:0072520)9.59069744
5positive regulation of RNA splicing (GO:0033120)9.47954231
6negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.01435112
7cAMP biosynthetic process (GO:0006171)8.78075753
8detection of chemical stimulus involved in sensory perception (GO:0050907)8.46332354
9negative regulation of alpha-beta T cell differentiation (GO:0046639)8.28356382
10enteric nervous system development (GO:0048484)7.72835243
11regulation of protein sumoylation (GO:0033233)7.39739639
12synaptic transmission, dopaminergic (GO:0001963)7.19773063
13dendritic spine morphogenesis (GO:0060997)6.92342244
14righting reflex (GO:0060013)6.86966786
15positive regulation of mitochondrial fission (GO:0090141)6.67885779
16heterotypic cell-cell adhesion (GO:0034113)6.38267690
17positive regulation of T-helper 1 type immune response (GO:0002827)6.25759645
18hepatocyte apoptotic process (GO:0097284)6.08386306
19detection of chemical stimulus (GO:0009593)6.06842110
20endothelial cell differentiation (GO:0045446)5.99608427
21arachidonic acid secretion (GO:0050482)5.98231596
22icosanoid secretion (GO:0032309)5.98231596
23phosphatidylinositol acyl-chain remodeling (GO:0036149)5.79338135
24positive regulation of T-helper cell differentiation (GO:0045624)5.77560158
25neural tube formation (GO:0001841)5.18561051
26drug transmembrane transport (GO:0006855)5.18429330
27phosphatidylserine acyl-chain remodeling (GO:0036150)5.12202088
28regulation of mitochondrial fission (GO:0090140)5.01320328
29phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.99155176
30fatty acid derivative transport (GO:1901571)4.92902663
31icosanoid transport (GO:0071715)4.92902663
32negative regulation of alpha-beta T cell activation (GO:0046636)4.86965038
33cilium or flagellum-dependent cell motility (GO:0001539)4.85011254
34neuronal ion channel clustering (GO:0045161)4.75188310
35chemosensory behavior (GO:0007635)4.71044342
36hyaluronan catabolic process (GO:0030214)4.60835158
37positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.55207799
38embryonic digestive tract morphogenesis (GO:0048557)4.52641536
39regulation of T-helper 1 type immune response (GO:0002825)4.48530537
40cyclic purine nucleotide metabolic process (GO:0052652)4.44640656
41ATP hydrolysis coupled proton transport (GO:0015991)4.34679665
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.34679665
43positive regulation of membrane potential (GO:0045838)4.30942701
44cyclic nucleotide biosynthetic process (GO:0009190)4.30917583
45vocalization behavior (GO:0071625)4.30311195
46nephron tubule morphogenesis (GO:0072078)4.30206096
47nephron epithelium morphogenesis (GO:0072088)4.30206096
48attachment of spindle microtubules to kinetochore (GO:0008608)4.28235204
49retina layer formation (GO:0010842)4.26315079
50negative regulation of actin filament bundle assembly (GO:0032232)4.24200271
51regulation of T-helper cell differentiation (GO:0045622)4.20195550
52regulation of cAMP-mediated signaling (GO:0043949)4.15427626
53water transport (GO:0006833)4.08622115
54positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.03090232
55dendritic spine organization (GO:0097061)4.01824800
56cellular response to glucagon stimulus (GO:0071377)4.01649569
57response to dietary excess (GO:0002021)4.00943881
58regulation of type 2 immune response (GO:0002828)3.99902757
59cAMP metabolic process (GO:0046058)3.99341804
60protein localization to synapse (GO:0035418)3.91797508
61cellular zinc ion homeostasis (GO:0006882)3.74555593
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.72981813
63negative regulation of T cell differentiation (GO:0045581)3.70112871
64monoamine transport (GO:0015844)3.67251466
65mitochondrial fusion (GO:0008053)3.67190814
66fluid transport (GO:0042044)3.63331431
67phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.60887300
68leukotriene biosynthetic process (GO:0019370)3.56528722
69drug transport (GO:0015893)3.53511638
70sequestering of metal ion (GO:0051238)3.51516064
71cellular response to ATP (GO:0071318)3.51053128
72cytoskeletal anchoring at plasma membrane (GO:0007016)3.49549253
73positive regulation of alpha-beta T cell differentiation (GO:0046638)3.46551425
74sulfur amino acid catabolic process (GO:0000098)3.43579678
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.41819129
76positive regulation of protein targeting to membrane (GO:0090314)3.39404196
77left/right axis specification (GO:0070986)3.37488086
78pre-miRNA processing (GO:0031054)3.36315616
79positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.36189621
80negative regulation of homotypic cell-cell adhesion (GO:0034111)3.32490870
81prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.20372769
82renal tubule morphogenesis (GO:0061333)3.12715880
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11527558
84phosphatidylcholine acyl-chain remodeling (GO:0036151)3.10937939
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10484632
86positive regulation of dendritic spine development (GO:0060999)3.09290622
87negative regulation of astrocyte differentiation (GO:0048712)3.09156931
88positive regulation of steroid hormone secretion (GO:2000833)3.06822911
89reflex (GO:0060004)3.04644728
90adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.04033402
91neurofilament cytoskeleton organization (GO:0060052)3.03611377
92regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.02217634
93adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.01957700
94tooth mineralization (GO:0034505)14.1038826
95detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6016030
96positive regulation of protein sumoylation (GO:0033235)11.7570467
97negative regulation of T-helper cell differentiation (GO:0045623)11.2245880
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.2245880
99protein K11-linked deubiquitination (GO:0035871)10.6024890
100regulation of T-helper 1 cell differentiation (GO:0045625)10.0164472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.35736599
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.23379913
3AR_21572438_ChIP-Seq_LNCaP_Human4.72939564
4IGF1R_20145208_ChIP-Seq_DFB_Human4.71785417
5VDR_22108803_ChIP-Seq_LS180_Human4.41434255
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.28757580
7TP53_16413492_ChIP-PET_HCT116_Human2.09089099
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03067209
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse11.6059972
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.91978350
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91748178
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91748178
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85008870
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78523965
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76250925
16GATA1_19941826_ChIP-Seq_K562_Human1.60707132
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59818443
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53558620
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50784981
20EGR1_19032775_ChIP-ChIP_M12_Human1.50661423
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48914044
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46029077
23DROSHA_22980978_ChIP-Seq_HELA_Human1.45191742
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.42708216
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.42320408
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.39567409
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35355926
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34828799
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.34560923
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.29809304
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29798662
32RNF2_27304074_Chip-Seq_NSC_Mouse1.27946539
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.25425523
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25344947
35RXR_22108803_ChIP-Seq_LS180_Human1.24027917
36TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.23702668
37ER_23166858_ChIP-Seq_MCF-7_Human1.20949606
38EZH2_22144423_ChIP-Seq_EOC_Human1.20582762
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19434452
40GBX2_23144817_ChIP-Seq_PC3_Human1.16623244
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13686125
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09624287
43HNFA_21074721_ChIP-Seq_CACO-2_Human1.07726806
44SOX2_18555785_Chip-Seq_ESCs_Mouse1.04658151
45GATA6_21074721_ChIP-Seq_CACO-2_Human1.04159472
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02729699
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02612199
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01920662
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01572281
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.00946988
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00441522
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00198989
53BCAT_22108803_ChIP-Seq_LS180_Human0.99870374
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99739238
55PRDM14_20953172_ChIP-Seq_ESCs_Human0.99701651
56SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98021155
57TBL1_22424771_ChIP-Seq_293T_Human0.97148642
58STAT3_23295773_ChIP-Seq_U87_Human0.96684972
59EED_16625203_ChIP-ChIP_MESCs_Mouse0.96669259
60HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96389628
61PHF8_20622853_ChIP-Seq_HELA_Human0.95448229
62CMYC_18555785_Chip-Seq_ESCs_Mouse0.94542488
63ARNT_22903824_ChIP-Seq_MCF-7_Human0.94303206
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94302249
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93990539
66SMAD4_21741376_ChIP-Seq_HESCs_Human0.93643612
67CBX2_27304074_Chip-Seq_ESCs_Mouse0.93235281
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93044704
69BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92816368
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92726194
71CJUN_26792858_Chip-Seq_BT549_Human0.91922603
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91733230
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91519002
74ZNF274_21170338_ChIP-Seq_K562_Hela0.90285827
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.89176392
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88674934
77CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88536929
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88425752
79SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87712025
80DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87178689
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86942777
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86787412
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86518378
84E2F1_18555785_Chip-Seq_ESCs_Mouse0.84922436
85SMAD4_21799915_ChIP-Seq_A2780_Human0.83890249
86KLF4_18555785_Chip-Seq_ESCs_Mouse0.83477736
87PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.82788290
88NANOG_16518401_ChIP-PET_MESCs_Mouse0.82642133
89NMYC_18555785_Chip-Seq_ESCs_Mouse0.82555186
90TCF4_22108803_ChIP-Seq_LS180_Human0.79306286
91P53_22387025_ChIP-Seq_ESCs_Mouse0.78964853
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78361018
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.78098400
94NANOG_20526341_ChIP-Seq_ESCs_Human0.77596965
95REST_21632747_ChIP-Seq_MESCs_Mouse0.77286115
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76606673
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76212850
98CBP_20019798_ChIP-Seq_JUKART_Human0.76212850
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76020507
100CTCF_27219007_Chip-Seq_Bcells_Human0.75847291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.83282570
2MP0004130_abnormal_muscle_cell4.89591119
3MP0004264_abnormal_extraembryonic_tissu3.93421173
4MP0003252_abnormal_bile_duct3.64011727
5MP0004133_heterotaxia2.72924290
6MP0002928_abnormal_bile_duct2.71727014
7MP0005448_abnormal_energy_balance2.39480100
8MP0006072_abnormal_retinal_apoptosis2.37219785
9MP0005408_hypopigmentation2.13241977
10MP0002751_abnormal_autonomic_nervous2.11121713
11MP0001270_distended_abdomen2.05664492
12MP0005084_abnormal_gallbladder_morpholo12.5902400
13MP0003329_amyloid_beta_deposits1.96195249
14MP0004272_abnormal_basement_membrane1.96069771
15MP0003943_abnormal_hepatobiliary_system1.88940710
16MP0005165_increased_susceptibility_to1.59433248
17MP0005220_abnormal_exocrine_pancreas1.57603619
18MP0009764_decreased_sensitivity_to1.51405192
19MP0005379_endocrine/exocrine_gland_phen1.48940644
20MP0003718_maternal_effect1.39305918
21MP0001958_emphysema1.37960444
22MP0001529_abnormal_vocalization1.35243753
23MP0000604_amyloidosis1.29209342
24MP0000465_gastrointestinal_hemorrhage1.11592418
25MP0001905_abnormal_dopamine_level1.10534514
26MP0005646_abnormal_pituitary_gland1.06415111
27MP0002572_abnormal_emotion/affect_behav1.04466792
28MP0000470_abnormal_stomach_morphology1.00266835
29MP0008569_lethality_at_weaning0.89158552
30MP0001944_abnormal_pancreas_morphology0.88177516
31MP0003638_abnormal_response/metabolism_0.85419330
32MP0000371_diluted_coat_color0.85070183
33MP0008469_abnormal_protein_level0.81640861
34MP0002405_respiratory_system_inflammati0.80241795
35MP0002098_abnormal_vibrissa_morphology0.79519104
36MP0001800_abnormal_humoral_immune0.78523127
37MP0002909_abnormal_adrenal_gland0.78319593
38MP0003121_genomic_imprinting0.76957195
39MP0002822_catalepsy0.76785098
40MP0005253_abnormal_eye_physiology0.75443528
41MP0005164_abnormal_response_to0.72975243
42MP0003866_abnormal_defecation0.66840140
43MP0000609_abnormal_liver_physiology0.66696534
44MP0000703_abnormal_thymus_morphology0.66079502
45MP0008875_abnormal_xenobiotic_pharmacok0.65829318
46MP0002693_abnormal_pancreas_physiology0.65799236
47MP0001851_eye_inflammation0.64809753
48MP0001915_intracranial_hemorrhage0.64290450
49MP0004019_abnormal_vitamin_homeostasis0.61858703
50MP0005387_immune_system_phenotype0.61702450
51MP0001790_abnormal_immune_system0.61702450
52MP0003953_abnormal_hormone_level0.60537411
53MP0002136_abnormal_kidney_physiology0.59061357
54MP0002078_abnormal_glucose_homeostasis0.57842599
55MP0001533_abnormal_skeleton_physiology0.54733532
56MP0005551_abnormal_eye_electrophysiolog0.52406017
57MP0001845_abnormal_inflammatory_respons0.50040659
58MP0001986_abnormal_taste_sensitivity0.49563720
59MP0003195_calcinosis0.48595284
60MP0009642_abnormal_blood_homeostasis0.47668087
61MP0002722_abnormal_immune_system0.47263267
62MP0001501_abnormal_sleep_pattern0.46868982
63MP0002998_abnormal_bone_remodeling0.45985953
64MP0005645_abnormal_hypothalamus_physiol0.45838514
65MP0003880_abnormal_central_pattern0.45424510
66MP0004947_skin_inflammation0.43395733
67MP0002419_abnormal_innate_immunity0.39837105
68MP0002429_abnormal_blood_cell0.38617271
69MP0008004_abnormal_stomach_pH0.38434541
70MP0005395_other_phenotype0.38294310
71MP0002735_abnormal_chemical_nociception0.37662803
72MP0000598_abnormal_liver_morphology0.37113959
73MP0002452_abnormal_antigen_presenting0.37075210
74MP0000759_abnormal_skeletal_muscle0.36732578
75MP0005365_abnormal_bile_salt0.34826060
76MP0001299_abnormal_eye_distance/0.34822406
77MP0001819_abnormal_immune_cell0.34770026
78MP0002420_abnormal_adaptive_immunity0.34690873
79MP0003136_yellow_coat_color0.34654099
80MP0009053_abnormal_anal_canal0.33676721
81MP0005334_abnormal_fat_pad0.33606622
82MP0000477_abnormal_intestine_morphology0.33405163
83MP0004484_altered_response_of0.33166127
84MP0002723_abnormal_immune_serum0.32668835
85MP0000716_abnormal_immune_system0.32361125
86MP0002882_abnormal_neuron_morphology0.32335478
87MP0000372_irregular_coat_pigmentation0.31798907
88MP0002229_neurodegeneration0.31649776
89MP0000920_abnormal_myelination0.31601077
90MP0009931_abnormal_skin_appearance0.31126307
91MP0006276_abnormal_autonomic_nervous0.29957650
92MP0002398_abnormal_bone_marrow0.29427660
93MP0005423_abnormal_somatic_nervous0.29134886
94MP0002396_abnormal_hematopoietic_system0.27553147
95MP0005503_abnormal_tendon_morphology0.27436230
96MP0005391_vision/eye_phenotype0.27405490
97MP0001293_anophthalmia0.26960160
98MP0000689_abnormal_spleen_morphology0.26218877
99MP0002161_abnormal_fertility/fecundity0.25826978
100MP0002736_abnormal_nociception_after0.25431348

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.65520211
2Abnormality of dental color (HP:0011073)8.10930253
3Abnormality of renal resorption (HP:0011038)7.87251810
4Polyuria (HP:0000103)7.81841803
5Osteomalacia (HP:0002749)7.49147823
6Abnormality of the dental pulp (HP:0006479)7.22094312
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.74024452
8Abnormal urine output (HP:0012590)6.66761342
9Abnormality of renal excretion (HP:0011036)5.80814644
10Round ear (HP:0100830)5.23444810
11Chronic bronchitis (HP:0004469)4.84326862
12Volvulus (HP:0002580)4.48382548
13IgM deficiency (HP:0002850)4.36397319
14Lip pit (HP:0100267)4.21509939
15Molar tooth sign on MRI (HP:0002419)4.09838607
16Abnormality of midbrain morphology (HP:0002418)4.09838607
17Toxemia of pregnancy (HP:0100603)4.01667641
18Autoimmune thrombocytopenia (HP:0001973)3.79716360
19Large earlobe (HP:0009748)3.67873796
20Esophageal varix (HP:0002040)3.64079455
21Nephrocalcinosis (HP:0000121)3.63940129
22Depressed nasal tip (HP:0000437)3.54014810
23Abnormal respiratory motile cilium physiology (HP:0012261)3.40639464
24Panhypogammaglobulinemia (HP:0003139)3.37681433
25Lipoatrophy (HP:0100578)3.34345434
26Rhinitis (HP:0012384)3.25725154
27Tachypnea (HP:0002789)3.18420159
28Drooling (HP:0002307)3.16828772
29Intestinal fistula (HP:0100819)3.11813722
30Excessive salivation (HP:0003781)3.02240720
31Nephronophthisis (HP:0000090)2.93562302
32Hypoparathyroidism (HP:0000829)2.93024283
33Sparse lateral eyebrow (HP:0005338)2.85962606
34Thick eyebrow (HP:0000574)2.84432117
35Petechiae (HP:0000967)2.76504765
36Personality changes (HP:0000751)2.75878952
37Hyperphosphaturia (HP:0003109)2.73460712
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.73308016
39Recurrent cutaneous fungal infections (HP:0011370)2.71548084
40Chronic mucocutaneous candidiasis (HP:0002728)2.71548084
41Dilated cardiomyopathy (HP:0001644)2.55622782
42Abnormality of transition element cation homeostasis (HP:0011030)2.43992316
43Hepatitis (HP:0012115)2.40997052
44Nephropathy (HP:0000112)2.37411515
45Colitis (HP:0002583)2.36175513
46Short 5th finger (HP:0009237)2.34070695
47Agammaglobulinemia (HP:0004432)2.33675832
48Inability to walk (HP:0002540)2.31236766
49Ureteral stenosis (HP:0000071)2.29338789
50Glycosuria (HP:0003076)2.27079735
51Abnormality of urine glucose concentration (HP:0011016)2.27079735
52Bronchitis (HP:0012387)2.27038624
53Abnormality of the renal medulla (HP:0100957)2.26768359
54Abnormal urine phosphate concentration (HP:0012599)2.25723776
55Gingival overgrowth (HP:0000212)2.24947735
56Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.22351555
57Sudden cardiac death (HP:0001645)2.14782132
58Abnormality of the fingertips (HP:0001211)2.13828377
59Preauricular pit (HP:0004467)2.12915834
60Periauricular skin pits (HP:0100277)2.12915834
61Ureteral obstruction (HP:0006000)2.09858239
62Abnormality of salivation (HP:0100755)2.01745246
63Striae distensae (HP:0001065)2.00779254
64Overgrowth (HP:0001548)11.6321070
65Amelogenesis imperfecta (HP:0000705)11.3864649
66Hypercalciuria (HP:0002150)1.97692456
67Anal stenosis (HP:0002025)1.97181075
68Recurrent otitis media (HP:0000403)1.96829354
69Decreased muscle mass (HP:0003199)1.95257662
70Ectopic kidney (HP:0000086)1.91084668
71Delayed eruption of teeth (HP:0000684)1.85462340
72Stage 5 chronic kidney disease (HP:0003774)1.85257018
73Small hand (HP:0200055)1.84431513
74Chorioretinal coloboma (HP:0000567)1.81884294
75Prominent supraorbital ridges (HP:0000336)1.78565569
76Chondrocalcinosis (HP:0000934)1.70805593
77Ectropion (HP:0000656)1.68309991
78Abnormality of Sharpey fibers (HP:0100685)1.67416204
79Skin pits (HP:0100276)1.66894390
80Preauricular skin tag (HP:0000384)1.66564609
81Oculomotor apraxia (HP:0000657)1.66052711
82Truncal ataxia (HP:0002078)1.65707387
83Bronchiectasis (HP:0002110)1.64913451
84Renal tubular dysfunction (HP:0000124)1.62980440
85Villous atrophy (HP:0011473)1.61127759
86Abnormality of small intestinal villus morphology (HP:0011472)1.61127759
87Skin tags (HP:0010609)1.56740911
88Palmoplantar keratoderma (HP:0000982)1.54763594
89Limited elbow extension (HP:0001377)1.54736175
90Blepharitis (HP:0000498)1.53863594
91Viral hepatitis (HP:0006562)1.52997923
92Polyneuropathy (HP:0001271)1.51028678
93Spontaneous abortion (HP:0005268)1.46495481
94Inflammation of the large intestine (HP:0002037)1.42644321
95Prenatal maternal abnormality (HP:0002686)1.40644660
96Highly arched eyebrow (HP:0002553)1.40592585
97Proximal placement of thumb (HP:0009623)1.40533736
98Mask-like facies (HP:0000298)1.40033099
99Abnormality of T cell physiology (HP:0011840)1.36453768
100Torticollis (HP:0000473)1.35116649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.46383351
2BLK4.28650953
3STK34.19314171
4RIPK43.11068983
5CDC42BPA2.16432469
6BMPR22.02817509
7NTRK213.8870583
8INSRR1.25808577
9HIPK21.12543040
10MAP4K20.97874422
11FGFR10.87236005
12OBSCN0.75847730
13SYK0.69365834
14TXK0.69184361
15ROCK20.68933360
16PRKAA10.68820575
17PRKCQ0.63752391
18FRK0.61311416
19SRC0.60600398
20GRK10.57373661
21MUSK0.56450198
22ROCK10.53690917
23LATS10.52538662
24EPHA40.50364719
25GRK70.48787134
26WNK30.47429338
27KDR0.46749510
28ADRBK20.46076767
29TAOK30.44168036
30TIE10.43579310
31PRKACG0.43080433
32PLK40.42761029
33ABL10.42405690
34PRKACB0.41937948
35TLK10.39565731
36STK40.39275874
37PRKACA0.38951898
38CAMK2A0.38608619
39PIK3CG0.38066430
40ERBB40.35692065
41MAPK150.35238628
42PHKG20.35217528
43PHKG10.35217528
44PLK10.31503030
45TEC0.30589864
46BCKDK0.27735803
47GRK60.26878677
48LYN0.26713553
49ZAK0.26635282
50MATK0.25706898
51PRKCA0.25355629
52MAPK140.24869084
53GSK3B0.24246746
54RPS6KA30.22862388
55PRKCB0.22612081
56WEE10.21522191
57WNK40.19734345
58OXSR10.19656391
59ABL20.19640171
60GRK50.18295497
61MAP2K60.18259276
62STK390.17801344
63KIT0.17038796
64BTK0.16777152
65CDK10.15969188
66NUAK10.15338027
67PKN10.14019770
68PRKCG0.13696646
69TGFBR20.13683987
70MAPK130.12984303
71SRPK10.12494720
72CSNK1A10.12410397
73PIK3CA0.12029216
74PRKG20.12028824
75MST1R0.11936357
76PRKDC0.11346123
77ADRBK10.11281058
78ITK0.11151962
79FYN0.10688735
80LMTK20.10578371
81PIM20.10482806
82PIM10.10261900
83PRKCD0.10173340
84MAPK90.10085031
85PRKCE0.09882276
86DDR20.09591112
87TNK20.08679878
88EGFR0.08576297
89CAMK2G0.08548075
90AKT10.08529177
91MOS0.08080453
92LCK0.07968873
93PINK10.07938504
94CHUK0.07053024
95IKBKE0.06622933
96IGF1R0.06557824
97HCK0.06444289
98TTN0.06320298
99SCYL20.05377118
100MAPKAPK50.05320003

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.36349782
2Sulfur relay system_Homo sapiens_hsa041223.69467158
3Sulfur metabolism_Homo sapiens_hsa009203.63986178
4Ovarian steroidogenesis_Homo sapiens_hsa049133.45054316
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.23076499
6Linoleic acid metabolism_Homo sapiens_hsa005912.98116396
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.79644245
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.73093772
9Collecting duct acid secretion_Homo sapiens_hsa049662.53237931
10Bile secretion_Homo sapiens_hsa049762.33211144
11Vibrio cholerae infection_Homo sapiens_hsa051102.26979362
12Salivary secretion_Homo sapiens_hsa049702.21775608
13Thyroid hormone synthesis_Homo sapiens_hsa049182.19715628
14Pancreatic secretion_Homo sapiens_hsa049722.18591084
15Gastric acid secretion_Homo sapiens_hsa049712.17747127
16Fat digestion and absorption_Homo sapiens_hsa049752.09028755
17Synaptic vesicle cycle_Homo sapiens_hsa047211.95281419
18Cocaine addiction_Homo sapiens_hsa050301.91557064
19Circadian entrainment_Homo sapiens_hsa047131.90050641
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.82026949
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78876541
22Insulin secretion_Homo sapiens_hsa049111.77473997
23Taste transduction_Homo sapiens_hsa047421.74311213
24Glutamatergic synapse_Homo sapiens_hsa047241.69455714
25Morphine addiction_Homo sapiens_hsa050321.67297164
26GABAergic synapse_Homo sapiens_hsa047271.64899423
27Dilated cardiomyopathy_Homo sapiens_hsa054141.60845823
28Ether lipid metabolism_Homo sapiens_hsa005651.60285373
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59900646
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.58867100
31Gap junction_Homo sapiens_hsa045401.52913173
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49768977
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.45296263
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42660593
35Amphetamine addiction_Homo sapiens_hsa050311.37552927
36Arachidonic acid metabolism_Homo sapiens_hsa005901.34237854
37GnRH signaling pathway_Homo sapiens_hsa049121.29626181
38Melanogenesis_Homo sapiens_hsa049161.27709803
39Platelet activation_Homo sapiens_hsa046111.22091366
40Oxytocin signaling pathway_Homo sapiens_hsa049211.20496705
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17464872
42Calcium signaling pathway_Homo sapiens_hsa040201.13749501
43Cholinergic synapse_Homo sapiens_hsa047251.12860297
44Circadian rhythm_Homo sapiens_hsa047101.12110967
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08437992
46Dorso-ventral axis formation_Homo sapiens_hsa043201.08033728
47Estrogen signaling pathway_Homo sapiens_hsa049151.01788661
48Oocyte meiosis_Homo sapiens_hsa041140.82109621
49Pyruvate metabolism_Homo sapiens_hsa006200.77433923
50Serotonergic synapse_Homo sapiens_hsa047260.76610001
51Chemokine signaling pathway_Homo sapiens_hsa040620.66155859
52Rheumatoid arthritis_Homo sapiens_hsa053230.64641265
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62990253
54ECM-receptor interaction_Homo sapiens_hsa045120.62429217
55Primary immunodeficiency_Homo sapiens_hsa053400.61998617
56RNA degradation_Homo sapiens_hsa030180.57929515
57cAMP signaling pathway_Homo sapiens_hsa040240.46998259
58Alcoholism_Homo sapiens_hsa050340.43528218
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42689681
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.41889928
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37340867
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35806679
63Parkinsons disease_Homo sapiens_hsa050120.34312288
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.34092948
65Purine metabolism_Homo sapiens_hsa002300.33962619
66Dopaminergic synapse_Homo sapiens_hsa047280.33118387
67Caffeine metabolism_Homo sapiens_hsa002320.31562438
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.30042922
69Staphylococcus aureus infection_Homo sapiens_hsa051500.28903865
70Retinol metabolism_Homo sapiens_hsa008300.28402223
71Hedgehog signaling pathway_Homo sapiens_hsa043400.25580196
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.25083797
73Systemic lupus erythematosus_Homo sapiens_hsa053220.20173623
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19980867
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18271468
76African trypanosomiasis_Homo sapiens_hsa051430.17508964
77Oxidative phosphorylation_Homo sapiens_hsa001900.16750239
78Type I diabetes mellitus_Homo sapiens_hsa049400.14849005
79Rap1 signaling pathway_Homo sapiens_hsa040150.14611444
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14381606
81Prion diseases_Homo sapiens_hsa050200.13980920
82Chemical carcinogenesis_Homo sapiens_hsa052040.13682056
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12893751
84Glucagon signaling pathway_Homo sapiens_hsa049220.11795884
85Phagosome_Homo sapiens_hsa041450.10570394
86HTLV-I infection_Homo sapiens_hsa051660.09192879
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.08913295
88Renin secretion_Homo sapiens_hsa049240.08072185
89Ras signaling pathway_Homo sapiens_hsa040140.07636615
90Tuberculosis_Homo sapiens_hsa051520.07113352
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.05079824
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.04899470
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.04219552
94Leishmaniasis_Homo sapiens_hsa051400.03891232
95ABC transporters_Homo sapiens_hsa020100.03072121
96Graft-versus-host disease_Homo sapiens_hsa053320.02069528
97Asthma_Homo sapiens_hsa053100.01860526
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.01557451
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.00631949
100Allograft rejection_Homo sapiens_hsa053300.00328154

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