OR7E47P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein sumoylation (GO:0033235)9.13423844
2negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)8.67383546
3negative regulation of T-helper cell differentiation (GO:0045623)8.67383546
4activation of protein kinase A activity (GO:0034199)7.97296845
5regulation of T-helper 2 cell differentiation (GO:0045628)7.95657562
6negative regulation of type 2 immune response (GO:0002829)7.63468499
7protein K11-linked deubiquitination (GO:0035871)7.28373441
8cilium movement (GO:0003341)7.24863266
9regulation of T-helper 1 cell differentiation (GO:0045625)7.23704097
10seminiferous tubule development (GO:0072520)6.91456206
11negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.83614613
12cAMP biosynthetic process (GO:0006171)6.76271356
13positive regulation of RNA splicing (GO:0033120)6.63662990
14detection of chemical stimulus involved in sensory perception (GO:0050907)6.57082199
15motile cilium assembly (GO:0044458)6.42681042
16negative regulation of alpha-beta T cell differentiation (GO:0046639)6.15682590
17regulation of protein sumoylation (GO:0033233)6.05500282
18enteric nervous system development (GO:0048484)5.76703874
19righting reflex (GO:0060013)5.36305725
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.33433792
21skeletal muscle contraction (GO:0003009)5.26488536
22epithelial cilium movement (GO:0003351)5.18273651
23left/right axis specification (GO:0070986)5.08653688
24positive regulation of mitochondrial fission (GO:0090141)5.04158746
25synaptic transmission, dopaminergic (GO:0001963)4.93864190
26dendritic spine morphogenesis (GO:0060997)4.86432003
27vitamin transmembrane transport (GO:0035461)4.83077815
28detection of chemical stimulus (GO:0009593)4.77999215
29icosanoid secretion (GO:0032309)4.75204698
30arachidonic acid secretion (GO:0050482)4.75204698
31heterotypic cell-cell adhesion (GO:0034113)4.62825161
32regulation of relaxation of muscle (GO:1901077)4.51783359
33endothelial cell differentiation (GO:0045446)4.26967500
34hepatocyte apoptotic process (GO:0097284)4.25581455
35drug transmembrane transport (GO:0006855)4.20003635
36positive regulation of T-helper 1 type immune response (GO:0002827)4.09090826
37muscle filament sliding (GO:0030049)4.08124752
38actin-myosin filament sliding (GO:0033275)4.08124752
39positive regulation of T-helper cell differentiation (GO:0045624)4.03791012
40chemosensory behavior (GO:0007635)4.00270697
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.94935290
42phosphatidylinositol acyl-chain remodeling (GO:0036149)3.93843245
43fatty acid derivative transport (GO:1901571)3.92064905
44icosanoid transport (GO:0071715)3.92064905
45phosphatidylserine acyl-chain remodeling (GO:0036150)3.84212054
46water transport (GO:0006833)3.81889981
47axoneme assembly (GO:0035082)3.75483229
48cyclic purine nucleotide metabolic process (GO:0052652)3.67215939
49neural tube formation (GO:0001841)3.66522244
50embryonic digestive tract morphogenesis (GO:0048557)3.64366327
51phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.60341863
52sarcoplasmic reticulum calcium ion transport (GO:0070296)3.58372726
53negative regulation of actin filament bundle assembly (GO:0032232)3.57318056
54regulation of cell communication by electrical coupling (GO:0010649)3.57027197
55regulation of mitochondrial fission (GO:0090140)3.53262976
56neuronal ion channel clustering (GO:0045161)3.51072483
57regulation of skeletal muscle contraction (GO:0014819)3.50668241
58cyclic nucleotide biosynthetic process (GO:0009190)3.49255546
59retina layer formation (GO:0010842)3.47705335
60actin-mediated cell contraction (GO:0070252)3.45464260
61hyaluronan catabolic process (GO:0030214)3.41184072
62fluid transport (GO:0042044)3.39889060
63negative regulation of homotypic cell-cell adhesion (GO:0034111)3.38779518
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.38757565
65vocalization behavior (GO:0071625)3.31544749
66negative regulation of alpha-beta T cell activation (GO:0046636)3.29379980
67striated muscle contraction (GO:0006941)3.25339466
68left/right pattern formation (GO:0060972)3.25012633
69nephron tubule morphogenesis (GO:0072078)3.22043978
70nephron epithelium morphogenesis (GO:0072088)3.22043978
71regulation of type 2 immune response (GO:0002828)3.21009551
72negative regulation of T cell differentiation (GO:0045581)3.17258770
73positive regulation of protein targeting to membrane (GO:0090314)3.15862467
74positive regulation of membrane potential (GO:0045838)3.01936311
75cellular response to glucagon stimulus (GO:0071377)3.00782246
76cAMP metabolic process (GO:0046058)2.99585942
77negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.98793271
78regulation of cAMP-mediated signaling (GO:0043949)2.98410028
79drug transport (GO:0015893)2.96996136
80skeletal muscle tissue development (GO:0007519)2.96560831
81cellular zinc ion homeostasis (GO:0006882)2.96114527
82regulation of T-helper cell differentiation (GO:0045622)2.95677121
83response to dietary excess (GO:0002021)2.94864574
84regulation of T-helper 1 type immune response (GO:0002825)2.91650341
85positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90824261
86ATP hydrolysis coupled proton transport (GO:0015991)2.89036498
87energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89036498
88mitochondrial fusion (GO:0008053)2.87470595
89primary alcohol catabolic process (GO:0034310)2.86878050
90single fertilization (GO:0007338)2.82587261
91dendritic spine organization (GO:0097061)2.76920320
92ethanol metabolic process (GO:0006067)2.74601127
93negative regulation of response to reactive oxygen species (GO:1901032)2.73051155
94regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.71393604
95regulation of cilium movement (GO:0003352)2.70946986
96response to muscle activity (GO:0014850)2.70927599
97tooth mineralization (GO:0034505)11.6708994
98axonemal dynein complex assembly (GO:0070286)10.6189408
99detection of chemical stimulus involved in sensory perception of smell (GO:0050911)10.5619107
100cilium or flagellum-dependent cell motility (GO:0001539)10.4084219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.26584800
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.24491168
3AR_21572438_ChIP-Seq_LNCaP_Human4.20638393
4IGF1R_20145208_ChIP-Seq_DFB_Human3.44219489
5VDR_22108803_ChIP-Seq_LS180_Human3.41932849
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.50059711
7DROSHA_22980978_ChIP-Seq_HELA_Human2.26897070
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.24799837
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.24225429
10ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.13845877
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.13635056
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74742335
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72587396
14YY1_22570637_ChIP-Seq_MALME-3M_Human1.62771943
15TP53_16413492_ChIP-PET_HCT116_Human1.62242015
16GATA1_19941826_ChIP-Seq_K562_Human1.61003784
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58467005
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58086926
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47019157
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47019157
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46961223
22SMAD3_21741376_ChIP-Seq_HESCs_Human1.44882242
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.42245999
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38607985
25CTCF_27219007_Chip-Seq_Bcells_Human1.36961166
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.33905079
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.33755752
28EZH2_22144423_ChIP-Seq_EOC_Human1.33199386
29RXR_22108803_ChIP-Seq_LS180_Human1.30828764
30NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24260207
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24049753
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.24026401
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21654784
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20101679
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19601534
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19249941
37HNFA_21074721_ChIP-Seq_CACO-2_Human1.17821796
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15843027
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.14628556
40TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13761657
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12861771
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12771901
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.12583270
44TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.12147875
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.11814768
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11246528
47STAT1_20625510_ChIP-Seq_HELA_Human1.09439053
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09066972
49TBL1_22424771_ChIP-Seq_293T_Human1.08720857
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07057698
51PHF8_20622853_ChIP-Seq_HELA_Human1.06289729
52GATA6_21074721_ChIP-Seq_CACO-2_Human1.05634499
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05537583
54ER_23166858_ChIP-Seq_MCF-7_Human1.04758083
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04535266
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04215483
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03503017
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02152414
59SMAD4_21741376_ChIP-Seq_HESCs_Human1.00519637
60CJUN_26792858_Chip-Seq_BT549_Human0.99617186
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99132100
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98486174
63JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97363074
64FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96403727
65RUNX1_27514584_Chip-Seq_MCF-7_Human0.96144258
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95230536
67EZH2_27304074_Chip-Seq_ESCs_Mouse0.93902238
68FOXO3_23340844_ChIP-Seq_DLD1_Human0.93492132
69RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92470356
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92171661
71PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92150992
72SMAD4_21799915_ChIP-Seq_A2780_Human0.90644001
73TP53_18474530_ChIP-ChIP_U2OS_Human0.90431170
74TRIM28_21343339_ChIP-Seq_HEK293_Human0.88916750
75ETV1_20927104_ChIP-Seq_GIST48_Human0.88867667
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88652008
77EED_16625203_ChIP-ChIP_MESCs_Mouse0.88018962
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87182022
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86975342
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86549296
81PRDM14_20953172_ChIP-Seq_ESCs_Human0.86181158
82EGR1_19032775_ChIP-ChIP_M12_Human0.85829711
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85500927
84AHR_22903824_ChIP-Seq_MCF-7_Human0.85352503
85GATA2_19941826_ChIP-Seq_K562_Human0.85241731
86TP63_22573176_ChIP-Seq_HFKS_Human0.85093914
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83921524
88NFYB_21822215_ChIP-Seq_K562_Human0.83888129
89STAT3_23295773_ChIP-Seq_U87_Human0.83375018
90TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83082224
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.81934806
92KLF5_25053715_ChIP-Seq_YYC3_Human0.81035536
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.80933733
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80780635
95HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80729806
96EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80478305
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80478305
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.80082565
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.80082565
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.79510449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo9.00058161
2MP0008961_abnormal_basal_metabolism7.48954834
3MP0004130_abnormal_muscle_cell4.92523823
4MP0004145_abnormal_muscle_electrophysio3.50832627
5MP0004264_abnormal_extraembryonic_tissu3.31390262
6MP0004133_heterotaxia2.98300977
7MP0003646_muscle_fatigue2.92682096
8MP0000751_myopathy2.76775517
9MP0003252_abnormal_bile_duct2.55884073
10MP0000749_muscle_degeneration2.55859036
11MP0008875_abnormal_xenobiotic_pharmacok2.28524386
12MP0001270_distended_abdomen2.21673527
13MP0004036_abnormal_muscle_relaxation2.19302274
14MP0000759_abnormal_skeletal_muscle2.06282672
15MP0004272_abnormal_basement_membrane2.01023845
16MP0002928_abnormal_bile_duct1.90702684
17MP0005165_increased_susceptibility_to1.70442101
18MP0002106_abnormal_muscle_physiology1.68539093
19MP0002132_abnormal_respiratory_system1.67560943
20MP0005448_abnormal_energy_balance1.65270240
21MP0004043_abnormal_pH_regulation1.59945053
22MP0009780_abnormal_chondrocyte_physiolo1.59790566
23MP0005369_muscle_phenotype1.56904427
24MP0006072_abnormal_retinal_apoptosis1.56412263
25MP0005620_abnormal_muscle_contractility1.54244501
26MP0005220_abnormal_exocrine_pancreas1.48492391
27MP0002332_abnormal_exercise_endurance1.42485470
28MP0000747_muscle_weakness1.42236045
29MP0002108_abnormal_muscle_morphology1.37745227
30MP0004084_abnormal_cardiac_muscle1.37514657
31MP0004087_abnormal_muscle_fiber1.30537371
32MP0001958_emphysema1.26569103
33MP0005408_hypopigmentation1.23677035
34MP0002277_abnormal_respiratory_mucosa1.22871198
35MP0004484_altered_response_of1.20800670
36MP0002269_muscular_atrophy1.18162593
37MP0001529_abnormal_vocalization1.15062160
38MP0005646_abnormal_pituitary_gland1.09757860
39MP0005164_abnormal_response_to1.08844218
40MP0001984_abnormal_olfaction1.08776751
41MP0000013_abnormal_adipose_tissue1.07795230
42MP0002751_abnormal_autonomic_nervous1.07514241
43MP0003329_amyloid_beta_deposits1.05743725
44MP0005330_cardiomyopathy1.03874212
45MP0000733_abnormal_muscle_development1.00342788
46MP0000465_gastrointestinal_hemorrhage0.98240096
47MP0000470_abnormal_stomach_morphology0.96950130
48MP0002909_abnormal_adrenal_gland0.95341048
49MP0002653_abnormal_ependyma_morphology0.93834693
50MP0001944_abnormal_pancreas_morphology0.93818704
51MP0002837_dystrophic_cardiac_calcinosis0.93207770
52MP0003943_abnormal_hepatobiliary_system0.92526238
53MP0004233_abnormal_muscle_weight0.91517671
54MP0002822_catalepsy0.91165909
55MP0008004_abnormal_stomach_pH0.90535920
56MP0005451_abnormal_body_composition0.88098608
57MP0001905_abnormal_dopamine_level0.86934016
58MP0004019_abnormal_vitamin_homeostasis0.86430034
59MP0002127_abnormal_cardiovascular_syste0.85826377
60MP0002078_abnormal_glucose_homeostasis0.85296884
61MP0002972_abnormal_cardiac_muscle0.84468006
62MP0009764_decreased_sensitivity_to0.79063073
63MP0000750_abnormal_muscle_regeneration0.77801333
64MP0005623_abnormal_meninges_morphology0.76296419
65MP0001299_abnormal_eye_distance/0.73415096
66MP0002160_abnormal_reproductive_system0.72840986
67MP0008789_abnormal_olfactory_epithelium0.72369337
68MP0002249_abnormal_larynx_morphology0.70161745
69MP0001765_abnormal_ion_homeostasis0.65865073
70MP0001664_abnormal_digestion0.65608091
71MP0004215_abnormal_myocardial_fiber0.65121546
72MP0002136_abnormal_kidney_physiology0.65076777
73MP0000678_abnormal_parathyroid_gland0.63602083
74MP0005379_endocrine/exocrine_gland_phen0.62205595
75MP0003953_abnormal_hormone_level0.56518583
76MP0003638_abnormal_response/metabolism_0.56217799
77MP0002693_abnormal_pancreas_physiology0.55400837
78MP0005253_abnormal_eye_physiology0.54085833
79MP0008569_lethality_at_weaning0.53374570
80MP0001986_abnormal_taste_sensitivity0.52954396
81MP0004085_abnormal_heartbeat0.52665660
82MP0005503_abnormal_tendon_morphology0.51436985
83MP0005636_abnormal_mineral_homeostasis0.50168266
84MP0002128_abnormal_blood_circulation0.49834356
85MP0002735_abnormal_chemical_nociception0.49404791
86MP0001346_abnormal_lacrimal_gland0.49202092
87MP0002572_abnormal_emotion/affect_behav0.48367581
88MP0006036_abnormal_mitochondrial_physio0.47983129
89MP0003879_abnormal_hair_cell0.46731989
90MP0003718_maternal_effect0.46082438
91MP0010368_abnormal_lymphatic_system0.45975927
92MP0005376_homeostasis/metabolism_phenot0.45904294
93MP0001915_intracranial_hemorrhage0.45091642
94MP0005083_abnormal_biliary_tract0.43155000
95MP0002168_other_aberrant_phenotype0.42397610
96MP0002998_abnormal_bone_remodeling0.42125277
97MP0004510_myositis0.41216941
98MP0002734_abnormal_mechanical_nocicepti0.41096481
99MP0008469_abnormal_protein_level0.40620239
100MP0005395_other_phenotype0.40543970

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.35763707
2Rhinitis (HP:0012384)7.87700615
3Chronic bronchitis (HP:0004469)7.21983614
4Abnormal respiratory motile cilium morphology (HP:0005938)7.14944617
5Abnormal respiratory epithelium morphology (HP:0012253)7.14944617
6Absent/shortened dynein arms (HP:0200106)6.94610741
7Dynein arm defect of respiratory motile cilia (HP:0012255)6.94610741
8Abnormal ciliary motility (HP:0012262)6.93822354
9Overgrowth (HP:0001548)5.94938446
10Amelogenesis imperfecta (HP:0000705)5.47269320
11Muscle fiber inclusion bodies (HP:0100299)5.37878974
12Bronchiectasis (HP:0002110)5.27942031
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.05806827
14Nemaline bodies (HP:0003798)4.96874719
15Round ear (HP:0100830)4.86720987
16Nasal polyposis (HP:0100582)4.57413685
17Abnormality of calcium-phosphate metabolism (HP:0100530)4.44746125
18Exercise-induced myalgia (HP:0003738)4.43135797
19Type 1 muscle fiber predominance (HP:0003803)4.39249671
20Abnormality of the dental pulp (HP:0006479)4.14355488
21Abnormality of the nasal mucosa (HP:0000433)3.92850573
22Polyuria (HP:0000103)3.79465687
23Bronchitis (HP:0012387)3.65922028
24Abnormality of dental color (HP:0011073)3.60075062
25Muscle hypertrophy of the lower extremities (HP:0008968)3.53591914
26Exercise-induced muscle cramps (HP:0003710)3.47839977
27Osteomalacia (HP:0002749)3.43140949
28Abnormality of renal resorption (HP:0011038)3.42352455
29Abnormal urine output (HP:0012590)3.21660195
30Distal arthrogryposis (HP:0005684)3.19234112
31Recurrent otitis media (HP:0000403)3.18888272
32Calf muscle hypertrophy (HP:0008981)3.18864814
33Lip pit (HP:0100267)3.04225911
34Muscle fiber splitting (HP:0003555)3.04181300
35Abnormality of renal excretion (HP:0011036)3.01892044
36Abnormality of the calf musculature (HP:0001430)2.97043192
37Myopathic facies (HP:0002058)2.96652938
38Infertility (HP:0000789)2.89978783
39Abnormality of midbrain morphology (HP:0002418)2.86078758
40Molar tooth sign on MRI (HP:0002419)2.86078758
41Recurrent sinusitis (HP:0011108)2.70454041
42Chronic sinusitis (HP:0011109)2.63749275
43Hyperkalemia (HP:0002153)2.57890310
44Nephronophthisis (HP:0000090)2.56934608
45Male infertility (HP:0003251)2.55237105
46EMG: myopathic abnormalities (HP:0003458)2.54913753
47Hyperactive renin-angiotensin system (HP:0000841)2.53779069
48Ulnar deviation of the wrist (HP:0003049)2.52072582
49Lipoatrophy (HP:0100578)2.46420742
50Hyporeflexia of lower limbs (HP:0002600)2.46415338
51Neck muscle weakness (HP:0000467)2.45086458
52Dilated cardiomyopathy (HP:0001644)2.26325669
53Centrally nucleated skeletal muscle fibers (HP:0003687)2.06320041
54Fetal akinesia sequence (HP:0001989)2.04007272
55Toxemia of pregnancy (HP:0100603)2.02337563
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8818564
57Distal lower limb muscle weakness (HP:0009053)1.99414947
58Rhabdomyolysis (HP:0003201)1.98378388
59Abnormality of the renal medulla (HP:0100957)1.95373818
60Atelectasis (HP:0100750)1.94363652
61Abnormality of skeletal muscle fiber size (HP:0012084)1.93639056
62Popliteal pterygium (HP:0009756)1.93255154
63Occipital encephalocele (HP:0002085)1.92151371
64Calcaneovalgus deformity (HP:0001848)1.90365341
65Myoglobinuria (HP:0002913)1.88009536
66Proximal amyotrophy (HP:0007126)1.78653684
67Absent phalangeal crease (HP:0006109)1.77519349
68Nephropathy (HP:0000112)1.76648742
69Depressed nasal tip (HP:0000437)1.76585587
70Frequent falls (HP:0002359)1.76460028
71Asymmetric septal hypertrophy (HP:0001670)1.76355202
72Decreased circulating renin level (HP:0003351)1.76147471
73Rimmed vacuoles (HP:0003805)1.75280502
74Nephrocalcinosis (HP:0000121)1.75199362
75Malignant hyperthermia (HP:0002047)1.74411188
76Increased variability in muscle fiber diameter (HP:0003557)1.69689161
77Sudden death (HP:0001699)1.69604117
78Deformed tarsal bones (HP:0008119)1.69445063
79Nonprogressive disorder (HP:0003680)1.66674791
80Chronic otitis media (HP:0000389)1.62646496
81Difficulty running (HP:0009046)1.62374121
82Scapular winging (HP:0003691)1.61815170
83Muscle stiffness (HP:0003552)1.60278469
84Bulbar palsy (HP:0001283)1.55942318
85True hermaphroditism (HP:0010459)1.55758578
86Pancreatic fibrosis (HP:0100732)1.54504166
87Limb-girdle muscle atrophy (HP:0003797)1.52569229
88Esophageal varix (HP:0002040)1.52430174
89Autoimmune thrombocytopenia (HP:0001973)1.52350187
90Mildly elevated creatine phosphokinase (HP:0008180)1.52128900
91Hip contracture (HP:0003273)1.51913227
92Sudden cardiac death (HP:0001645)1.51602570
93Ventricular fibrillation (HP:0001663)1.49729969
94Subaortic stenosis (HP:0001682)1.49710370
95Abnormality of the left ventricular outflow tract (HP:0011103)1.49710370
96Stage 5 chronic kidney disease (HP:0003774)1.48581046
97Renal salt wasting (HP:0000127)1.47517379
98Abnormality of sodium homeostasis (HP:0010931)1.45015914
99Gowers sign (HP:0003391)1.44345552
100Stridor (HP:0010307)1.44327338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.78066488
2MAPK154.55525351
3MAP4K13.35262334
4STK33.03992523
5BLK2.94077003
6PHKG22.77224530
7PHKG12.77224530
8TTN2.55319748
9PINK12.46026778
10CDC42BPA2.27289207
11RIPK42.09628614
12NTRK210.0746863
13PIK3CG1.58568945
14EPHA21.50433879
15MAPKAPK31.37457194
16MYLK1.34425476
17MST41.34067400
18EEF2K1.29552472
19MUSK1.14426616
20FRK1.12287667
21NME11.10304769
22HIPK21.06258869
23TRPM70.99516451
24MAPK120.98401924
25MAP3K70.95045523
26ROCK10.88072634
27PRKAA10.85761859
28TIE10.83551549
29BMPR20.79708125
30STK240.73903522
31PRKCQ0.72075295
32ROCK20.65356116
33LATS10.64801042
34INSRR0.63904672
35MAP3K30.60211243
36STK38L0.58991577
37CAMK2G0.56572883
38MARK30.56042816
39TLK10.54848846
40PTK2B0.50578325
41GRK10.49491857
42GRK70.49479225
43SGK2230.47673345
44SGK4940.47673345
45PRKACA0.45020708
46PRKAA20.44599792
47SGK20.42969514
48STK390.41728169
49MAP2K60.39896301
50FGFR10.38908949
51TRIB30.38847301
52MAP2K40.38392976
53MARK20.36709023
54SGK10.36120097
55AKT30.35780866
56RIPK10.34924756
57SRC0.34579369
58CAMK2A0.33187181
59MAP2K70.32399083
60MST1R0.32166530
61ADRBK20.30401180
62NLK0.30372417
63PRKACG0.30330391
64MAP3K130.30181875
65EPHB10.30113300
66STK380.29595121
67AKT20.28159108
68MOS0.27699142
69RPS6KA30.27099906
70PRKG10.26668301
71OXSR10.26064646
72ICK0.26040749
73ADRBK10.25074007
74MAP2K30.24818730
75MAP3K20.24669628
76PRKACB0.24104843
77PDPK10.23872811
78TAOK10.23565058
79ABL10.23417361
80TBK10.22440832
81SGK30.21717355
82LATS20.20742391
83RPS6KB10.19903854
84PRKCA0.18425660
85CCNB10.17888793
86CDK30.17510535
87RPS6KA20.16947105
88CAMK10.16541001
89MAP2K10.16086707
90MAPK130.15278051
91GRK60.14746687
92MAPK70.14192499
93GSK3B0.14126274
94CSK0.14095702
95TNK20.13679547
96PRKD30.12787579
97PRKG20.11384578
98NEK90.11357992
99ERBB40.11067566
100WNK40.10951199

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.59151963
2Sulfur relay system_Homo sapiens_hsa041222.69984889
3Ovarian steroidogenesis_Homo sapiens_hsa049132.68103934
4Dilated cardiomyopathy_Homo sapiens_hsa054142.65103499
5Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.55981079
6Linoleic acid metabolism_Homo sapiens_hsa005912.55126444
7Sulfur metabolism_Homo sapiens_hsa009202.50746169
8Salivary secretion_Homo sapiens_hsa049702.34816959
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.29908965
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27639249
11Circadian rhythm_Homo sapiens_hsa047102.21367328
12Gastric acid secretion_Homo sapiens_hsa049712.11319525
13Vascular smooth muscle contraction_Homo sapiens_hsa042702.06210167
14Bile secretion_Homo sapiens_hsa049762.00378251
15Pancreatic secretion_Homo sapiens_hsa049721.86952850
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.82935308
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76085295
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72968994
19Oxytocin signaling pathway_Homo sapiens_hsa049211.68186622
20Thyroid hormone synthesis_Homo sapiens_hsa049181.67822758
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66194401
22Insulin secretion_Homo sapiens_hsa049111.64241916
23Collecting duct acid secretion_Homo sapiens_hsa049661.62710526
24Phenylalanine metabolism_Homo sapiens_hsa003601.62701876
25Cocaine addiction_Homo sapiens_hsa050301.60595304
26Vibrio cholerae infection_Homo sapiens_hsa051101.60352277
27Calcium signaling pathway_Homo sapiens_hsa040201.57976308
28Circadian entrainment_Homo sapiens_hsa047131.55642380
29Gap junction_Homo sapiens_hsa045401.52845127
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.52597310
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41872212
32Taste transduction_Homo sapiens_hsa047421.39021137
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35165353
34GnRH signaling pathway_Homo sapiens_hsa049121.34003435
35Melanogenesis_Homo sapiens_hsa049161.32533923
36Synaptic vesicle cycle_Homo sapiens_hsa047211.32458783
37Amphetamine addiction_Homo sapiens_hsa050311.32051394
38Chemical carcinogenesis_Homo sapiens_hsa052041.29329149
39Fat digestion and absorption_Homo sapiens_hsa049751.27161615
40Histidine metabolism_Homo sapiens_hsa003401.22817285
41Glutamatergic synapse_Homo sapiens_hsa047241.18888297
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17912061
43Arachidonic acid metabolism_Homo sapiens_hsa005901.16686522
44GABAergic synapse_Homo sapiens_hsa047271.15212975
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13897919
46Tyrosine metabolism_Homo sapiens_hsa003501.05377477
47Pyruvate metabolism_Homo sapiens_hsa006201.01724304
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00215725
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97847546
50Estrogen signaling pathway_Homo sapiens_hsa049150.97628121
51Cholinergic synapse_Homo sapiens_hsa047250.97001457
52Morphine addiction_Homo sapiens_hsa050320.95731531
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95526630
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92810742
55Glucagon signaling pathway_Homo sapiens_hsa049220.91344103
56Platelet activation_Homo sapiens_hsa046110.88990467
57Ether lipid metabolism_Homo sapiens_hsa005650.86124839
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78694708
59ECM-receptor interaction_Homo sapiens_hsa045120.77437134
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70668709
61beta-Alanine metabolism_Homo sapiens_hsa004100.66609729
62Dorso-ventral axis formation_Homo sapiens_hsa043200.65394927
63Retinol metabolism_Homo sapiens_hsa008300.65048645
64Serotonergic synapse_Homo sapiens_hsa047260.62950901
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62737398
66cAMP signaling pathway_Homo sapiens_hsa040240.62198216
67Insulin resistance_Homo sapiens_hsa049310.61707336
68Renin secretion_Homo sapiens_hsa049240.53305854
69Insulin signaling pathway_Homo sapiens_hsa049100.51980576
70Cardiac muscle contraction_Homo sapiens_hsa042600.48586375
71Oocyte meiosis_Homo sapiens_hsa041140.48376524
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.46150855
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.46029022
74Hedgehog signaling pathway_Homo sapiens_hsa043400.45759244
75ABC transporters_Homo sapiens_hsa020100.42950477
76Starch and sucrose metabolism_Homo sapiens_hsa005000.42333319
77Huntingtons disease_Homo sapiens_hsa050160.40103507
78Glutathione metabolism_Homo sapiens_hsa004800.37272444
79Tight junction_Homo sapiens_hsa045300.36239102
80Phototransduction_Homo sapiens_hsa047440.35668268
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.33851758
82Alcoholism_Homo sapiens_hsa050340.30813647
83Dopaminergic synapse_Homo sapiens_hsa047280.27631698
84Caffeine metabolism_Homo sapiens_hsa002320.24763390
85Arginine and proline metabolism_Homo sapiens_hsa003300.22443104
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22335734
87Complement and coagulation cascades_Homo sapiens_hsa046100.21749028
88Arginine biosynthesis_Homo sapiens_hsa002200.21645463
89AMPK signaling pathway_Homo sapiens_hsa041520.21426781
90Nitrogen metabolism_Homo sapiens_hsa009100.21307073
91Chemokine signaling pathway_Homo sapiens_hsa040620.20605650
92Purine metabolism_Homo sapiens_hsa002300.19668903
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19194419
94Fatty acid degradation_Homo sapiens_hsa000710.19144674
95Amoebiasis_Homo sapiens_hsa051460.18890614
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.18844363
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16989162
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15250996
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14719608
100Rheumatoid arthritis_Homo sapiens_hsa053230.14678163

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »