OR7E55P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.63797757
2water-soluble vitamin biosynthetic process (GO:0042364)6.03329555
3purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.93575721
43-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.93575721
5negative regulation by host of viral transcription (GO:0043922)5.78662411
6regulation of glomerulus development (GO:0090192)5.09232749
7sulfation (GO:0051923)4.98943636
8gamma-aminobutyric acid transport (GO:0015812)4.83060783
9head development (GO:0060322)4.81551633
10epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.74221907
11cellular anion homeostasis (GO:0030002)4.50289796
12negative regulation of protein autophosphorylation (GO:0031953)4.47338084
13regulation of cell proliferation involved in kidney development (GO:1901722)4.40836627
14cytidine deamination (GO:0009972)4.32919488
15cytidine metabolic process (GO:0046087)4.32919488
16cytidine catabolic process (GO:0006216)4.32919488
17negative regulation of T cell differentiation in thymus (GO:0033085)4.17117826
18behavioral response to ethanol (GO:0048149)3.96302038
19parturition (GO:0007567)3.94293524
20cellular response to ATP (GO:0071318)3.94235702
21positive regulation of fatty acid oxidation (GO:0046321)3.88359529
22negative regulation of glycogen biosynthetic process (GO:0045719)3.82497473
23chaperone-mediated protein transport (GO:0072321)3.75526920
24DNA deamination (GO:0045006)3.75290282
25regulation of apoptotic process involved in morphogenesis (GO:1902337)3.72045855
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.71805948
27glycerol metabolic process (GO:0006071)3.68393912
28negative regulation of catenin import into nucleus (GO:0035414)3.65505758
29negative regulation of transcription regulatory region DNA binding (GO:2000678)3.64603494
30lymphangiogenesis (GO:0001946)3.64415807
31positive regulation of cAMP-mediated signaling (GO:0043950)3.63325698
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.59650562
33negative regulation of platelet activation (GO:0010544)3.58307935
34GPI anchor metabolic process (GO:0006505)3.54161441
35L-fucose catabolic process (GO:0042355)3.52288894
36fucose catabolic process (GO:0019317)3.52288894
37L-fucose metabolic process (GO:0042354)3.52288894
38cell proliferation in forebrain (GO:0021846)3.49995153
39estrogen metabolic process (GO:0008210)3.49864459
40positive regulation of metanephros development (GO:0072216)3.48197274
41centriole replication (GO:0007099)3.45515825
42tooth mineralization (GO:0034505)3.38300801
43pyrimidine ribonucleoside catabolic process (GO:0046133)3.37606415
44opsonization (GO:0008228)3.36521178
45regulation of DNA endoreduplication (GO:0032875)3.35694327
46alditol metabolic process (GO:0019400)3.34452459
47lung morphogenesis (GO:0060425)3.29429729
48pharyngeal system development (GO:0060037)3.27621319
49somite development (GO:0061053)3.26276346
50angiogenesis involved in wound healing (GO:0060055)3.20556761
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20167598
52white fat cell differentiation (GO:0050872)3.18528916
53positive regulation of glomerulus development (GO:0090193)3.16619475
54regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.10619092
55otic vesicle formation (GO:0030916)3.10077917
56negative regulation of viral transcription (GO:0032897)3.09974346
57negative regulation of cardiac muscle tissue development (GO:0055026)3.08500340
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08165790
59regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.06363454
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06099188
61negative regulation of axon extension involved in axon guidance (GO:0048843)2.99263230
62basic amino acid transport (GO:0015802)2.95587960
63endoderm formation (GO:0001706)2.94977727
64positive regulation of odontogenesis (GO:0042482)2.92936899
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90703454
66positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.86003499
67negative regulation of telomere maintenance (GO:0032205)2.85909938
68alanine transport (GO:0032328)2.84565911
69nucleoside bisphosphate metabolic process (GO:0033865)2.83364412
70purine nucleoside bisphosphate metabolic process (GO:0034032)2.83364412
71ribonucleoside bisphosphate metabolic process (GO:0033875)2.83364412
72phosphate ion homeostasis (GO:0055062)2.82511170
73trivalent inorganic anion homeostasis (GO:0072506)2.82511170
74peptidyl-tyrosine autophosphorylation (GO:0038083)2.81673812
75negative regulation of glycogen metabolic process (GO:0070874)2.80762996
76regulation of metanephros development (GO:0072215)2.80380903
77modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.79294280
78modulation by host of viral transcription (GO:0043921)2.78873509
79modulation by host of symbiont transcription (GO:0052472)2.78873509
80indolalkylamine metabolic process (GO:0006586)2.77828680
81kynurenine metabolic process (GO:0070189)2.77614443
82embryonic hindlimb morphogenesis (GO:0035116)2.77290628
83intracellular protein transmembrane import (GO:0044743)2.74756999
84cellular response to lithium ion (GO:0071285)2.73153012
85negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.72741305
86response to pheromone (GO:0019236)2.71182608
87vitamin biosynthetic process (GO:0009110)2.70986867
88negative regulation of oligodendrocyte differentiation (GO:0048715)2.68651953
89negative regulation of glial cell differentiation (GO:0045686)2.68424196
90mesonephros development (GO:0001823)2.67987672
91energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67008711
92ATP synthesis coupled proton transport (GO:0015986)2.67008711
93regulation of sequestering of triglyceride (GO:0010889)2.66112205
94proteasome assembly (GO:0043248)2.64475095
95regulation of lymphocyte chemotaxis (GO:1901623)2.62766618
96regulation of protein autophosphorylation (GO:0031952)2.61503102
97cardiac epithelial to mesenchymal transition (GO:0060317)2.60623893
98indole-containing compound catabolic process (GO:0042436)2.59345309
99indolalkylamine catabolic process (GO:0046218)2.59345309
100tryptophan catabolic process (GO:0006569)2.59345309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07575438
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.45947267
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.48579322
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.13876449
5EED_16625203_ChIP-ChIP_MESCs_Mouse3.09410991
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53528453
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.49975723
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47769711
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47096882
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.43953517
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.31806720
12GBX2_23144817_ChIP-Seq_PC3_Human2.12602220
13ZNF274_21170338_ChIP-Seq_K562_Hela2.11069718
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04549521
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02830518
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00064435
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98262222
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95960535
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93926986
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93335683
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.88572567
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87840063
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.85962999
24EWS_26573619_Chip-Seq_HEK293_Human1.79751715
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77697533
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76255704
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72626392
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72009300
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64753026
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.64502118
31AR_21572438_ChIP-Seq_LNCaP_Human1.59619131
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52834179
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48358246
34RNF2_27304074_Chip-Seq_NSC_Mouse1.47660603
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47042815
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44558878
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44416864
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41839103
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40920048
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40920048
41REST_21632747_ChIP-Seq_MESCs_Mouse1.40880067
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40389303
43CBP_20019798_ChIP-Seq_JUKART_Human1.40389303
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40202881
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.38324328
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33213383
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32888930
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31994284
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.30089853
50VDR_22108803_ChIP-Seq_LS180_Human1.27709365
51NCOR_22424771_ChIP-Seq_293T_Human1.27629682
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24593548
53P300_19829295_ChIP-Seq_ESCs_Human1.23975478
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21655077
55SCL_19346495_ChIP-Seq_HPC-7_Human1.19885401
56TDRD3_21172665_ChIP-Seq_MCF-7_Human1.17003130
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16829428
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.14846260
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12710204
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11796278
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11765973
62ERA_21632823_ChIP-Seq_H3396_Human1.11430885
63SMAD4_21741376_ChIP-Seq_HESCs_Human1.11205870
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08063277
65NANOG_19829295_ChIP-Seq_ESCs_Human1.05322233
66SOX2_19829295_ChIP-Seq_ESCs_Human1.05322233
67MYC_18940864_ChIP-ChIP_HL60_Human1.04296721
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.03364929
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03280311
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.02542534
71FUS_26573619_Chip-Seq_HEK293_Human1.01827849
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01659207
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.00417736
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99069961
75ELK1_19687146_ChIP-ChIP_HELA_Human0.98399984
76ER_23166858_ChIP-Seq_MCF-7_Human0.95558369
77PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95070008
78NANOG_20526341_ChIP-Seq_ESCs_Human0.94521835
79SMAD3_21741376_ChIP-Seq_EPCs_Human0.92875450
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92831596
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90464772
82TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89041522
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88661450
84EP300_21415370_ChIP-Seq_HL-1_Mouse0.87270660
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86970655
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.84888280
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84581168
88RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84250113
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.84189804
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84189804
91FOXH1_21741376_ChIP-Seq_ESCs_Human0.83243921
92BCAT_22108803_ChIP-Seq_LS180_Human0.83038534
93AR_25329375_ChIP-Seq_VCAP_Human0.82874820
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80453896
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79388069
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77017848
97TP53_22573176_ChIP-Seq_HFKS_Human0.75330443
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.75205898
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.74885257
100TP53_18474530_ChIP-ChIP_U2OS_Human0.74773446

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis6.24001319
2MP0006054_spinal_hemorrhage3.93789356
3MP0004145_abnormal_muscle_electrophysio3.68649440
4MP0000049_abnormal_middle_ear2.84412889
5MP0002138_abnormal_hepatobiliary_system2.55445746
6MP0002160_abnormal_reproductive_system2.53760980
7MP0005646_abnormal_pituitary_gland2.38733498
8MP0009379_abnormal_foot_pigmentation2.27850095
9MP0001485_abnormal_pinna_reflex2.25428178
10MP0000537_abnormal_urethra_morphology2.23755353
11MP0000631_abnormal_neuroendocrine_gland2.13173421
12MP0003011_delayed_dark_adaptation2.12830946
13MP0004133_heterotaxia2.12332786
14MP0005670_abnormal_white_adipose2.03250591
15MP0000516_abnormal_urinary_system1.97990629
16MP0005367_renal/urinary_system_phenotyp1.97990629
17MP0009053_abnormal_anal_canal1.97582440
18MP0004885_abnormal_endolymph1.94592118
19MP0004134_abnormal_chest_morphology1.94412273
20MP0005503_abnormal_tendon_morphology1.91395768
21MP0003119_abnormal_digestive_system1.87397531
22MP0001986_abnormal_taste_sensitivity1.71348229
23MP0005389_reproductive_system_phenotype1.68499910
24MP0009250_abnormal_appendicular_skeleto1.66613169
25MP0004742_abnormal_vestibular_system1.64940068
26MP0004142_abnormal_muscle_tone1.63247455
27MP0004270_analgesia1.56263690
28MP0005083_abnormal_biliary_tract1.53851441
29MP0004130_abnormal_muscle_cell1.51602750
30MP0005623_abnormal_meninges_morphology1.48675461
31MP0003942_abnormal_urinary_system1.48236176
32MP0010368_abnormal_lymphatic_system1.47842929
33MP0002837_dystrophic_cardiac_calcinosis1.43826069
34MP0003937_abnormal_limbs/digits/tail_de1.34925417
35MP0009745_abnormal_behavioral_response1.32786291
36MP0002733_abnormal_thermal_nociception1.30825894
37MP0000678_abnormal_parathyroid_gland1.29822577
38MP0002734_abnormal_mechanical_nocicepti1.25261125
39MP0002102_abnormal_ear_morphology1.25092006
40MP0003646_muscle_fatigue1.24983409
41MP0009384_cardiac_valve_regurgitation1.22953488
42MP0005551_abnormal_eye_electrophysiolog1.21432830
43MP0002735_abnormal_chemical_nociception1.21010902
44MP0001188_hyperpigmentation1.20191370
45MP0008872_abnormal_physiological_respon1.20067813
46MP0000230_abnormal_systemic_arterial1.17425714
47MP0006292_abnormal_olfactory_placode1.15173292
48MP0000538_abnormal_urinary_bladder1.11489268
49MP0003938_abnormal_ear_development1.09543083
50MP0002108_abnormal_muscle_morphology1.08614923
51MP0002876_abnormal_thyroid_physiology1.03923848
52MP0001542_abnormal_bone_strength1.02618533
53MP0004215_abnormal_myocardial_fiber1.02080302
54MP0008007_abnormal_cellular_replicative1.01922229
55MP0006276_abnormal_autonomic_nervous1.01381360
56MP0002139_abnormal_hepatobiliary_system0.99276429
57MP0005360_urolithiasis0.99049910
58MP0003787_abnormal_imprinting0.98634104
59MP0005410_abnormal_fertilization0.98095843
60MP0005084_abnormal_gallbladder_morpholo0.97132023
61MP0002272_abnormal_nervous_system0.96769993
62MP0002163_abnormal_gland_morphology0.96436350
63MP0000534_abnormal_ureter_morphology0.96176359
64MP0002653_abnormal_ependyma_morphology0.95845038
65MP0000026_abnormal_inner_ear0.95704258
66MP0008569_lethality_at_weaning0.95574952
67MP0003879_abnormal_hair_cell0.93936774
68MP0005253_abnormal_eye_physiology0.89370871
69MP0005165_increased_susceptibility_to0.88784640
70MP0001970_abnormal_pain_threshold0.87073635
71MP0002933_joint_inflammation0.86764893
72MP0000767_abnormal_smooth_muscle0.84070602
73MP0001502_abnormal_circadian_rhythm0.84043061
74MP0000003_abnormal_adipose_tissue0.83660262
75MP0004185_abnormal_adipocyte_glucose0.83177348
76MP0003638_abnormal_response/metabolism_0.82017643
77MP0002184_abnormal_innervation0.81921375
78MP0001963_abnormal_hearing_physiology0.81697160
79MP0002064_seizures0.81576280
80MP0002132_abnormal_respiratory_system0.80851649
81MP0000639_abnormal_adrenal_gland0.79797679
82MP0003806_abnormal_nucleotide_metabolis0.77306913
83MP0002928_abnormal_bile_duct0.77064172
84MP0008877_abnormal_DNA_methylation0.74800256
85MP0003950_abnormal_plasma_membrane0.74426748
86MP0002282_abnormal_trachea_morphology0.74060633
87MP0001984_abnormal_olfaction0.73038055
88MP0001968_abnormal_touch/_nociception0.72562036
89MP0003693_abnormal_embryo_hatching0.72274053
90MP0002752_abnormal_somatic_nervous0.70103328
91MP0001905_abnormal_dopamine_level0.69502497
92MP0005195_abnormal_posterior_eye0.69365636
93MP0002277_abnormal_respiratory_mucosa0.67169938
94MP0002932_abnormal_joint_morphology0.65844618
95MP0003137_abnormal_impulse_conducting0.65832485
96MP0005595_abnormal_vascular_smooth0.65567499
97MP0005620_abnormal_muscle_contractility0.62821039
98MP0001919_abnormal_reproductive_system0.62160610
99MP0000163_abnormal_cartilage_morphology0.61246572
100MP0002067_abnormal_sensory_capabilities0.60003154

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)4.02540607
2Pancreatic cysts (HP:0001737)3.99324605
3True hermaphroditism (HP:0010459)3.86484768
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.86440804
5Vascular calcification (HP:0004934)3.75945400
6Pancreatic fibrosis (HP:0100732)3.72758845
7Severe visual impairment (HP:0001141)3.67692143
8Abolished electroretinogram (ERG) (HP:0000550)3.54223454
9Hypoplastic pelvis (HP:0008839)3.49339107
10Morphological abnormality of the middle ear (HP:0008609)3.47232670
11Patent foramen ovale (HP:0001655)3.44678787
12Asplenia (HP:0001746)3.44593992
13Agitation (HP:0000713)3.40474322
14Aplasia/Hypoplasia of the spleen (HP:0010451)3.39240435
15Hypophosphatemic rickets (HP:0004912)3.38890966
16Bile duct proliferation (HP:0001408)3.35998177
17Abnormal biliary tract physiology (HP:0012439)3.35998177
18Cardiovascular calcification (HP:0011915)3.28921967
19Short hallux (HP:0010109)3.27594975
20Abnormal rod and cone electroretinograms (HP:0008323)3.18670553
21Cystic liver disease (HP:0006706)3.18642401
22Gonadotropin excess (HP:0000837)3.18329816
23Genetic anticipation (HP:0003743)3.13913914
24Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.13091516
25Short 1st metacarpal (HP:0010034)3.13091516
26Abnormality of the right ventricle (HP:0001707)3.04753896
27Hemiparesis (HP:0001269)3.01474587
28Aplasia/Hypoplasia of the hallux (HP:0008362)2.94422847
29Congenital, generalized hypertrichosis (HP:0004540)2.90375861
30Hypoplasia of the thymus (HP:0000778)2.85282949
31Keratoconus (HP:0000563)2.83903952
32Increased corneal curvature (HP:0100692)2.83903952
333-Methylglutaconic aciduria (HP:0003535)2.79381485
34Hemiplegia (HP:0002301)2.78878698
35Abnormality of the 1st metacarpal (HP:0010009)2.74250114
36Anencephaly (HP:0002323)2.63754927
37Confusion (HP:0001289)2.59929239
38Fibular hypoplasia (HP:0003038)2.59678735
39Progressive cerebellar ataxia (HP:0002073)2.55925748
40Porencephaly (HP:0002132)2.54847317
41Decreased central vision (HP:0007663)2.53560175
42Absent/shortened dynein arms (HP:0200106)2.51680829
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.51680829
44Adrenal hypoplasia (HP:0000835)2.50320625
45Abnormality of binocular vision (HP:0011514)2.47951182
46Diplopia (HP:0000651)2.47951182
47Short phalanx of the thumb (HP:0009660)2.38914456
48Attenuation of retinal blood vessels (HP:0007843)2.38011705
49Bilateral microphthalmos (HP:0007633)2.36380479
50Abnormal number of erythroid precursors (HP:0012131)2.29057347
51Sclerocornea (HP:0000647)2.26284864
52Abnormal pancreas size (HP:0012094)2.17513127
53Congenital stationary night blindness (HP:0007642)2.14500135
54Sloping forehead (HP:0000340)2.14152032
55Abnormal lung lobation (HP:0002101)2.13081312
56Abnormality of the middle phalanges of the toes (HP:0010183)2.06698507
57Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.06453411
58Short tibia (HP:0005736)2.06395416
59Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06276503
60Fused cervical vertebrae (HP:0002949)2.05505241
61Abnormality of the proximal phalanges of the hand (HP:0009834)2.02448090
62Absent thumb (HP:0009777)2.00826559
63Constricted visual fields (HP:0001133)1.98976119
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98864239
65Thyroiditis (HP:0100646)1.97947116
66Aplasia/Hypoplasia of the fibula (HP:0006492)1.96411227
67Methylmalonic acidemia (HP:0002912)1.92828322
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.92515190
69Abnormality of midbrain morphology (HP:0002418)1.91172988
70Molar tooth sign on MRI (HP:0002419)1.91172988
71Abnormality of cells of the erythroid lineage (HP:0012130)1.90467162
72Microretrognathia (HP:0000308)1.89946836
73Congenital hepatic fibrosis (HP:0002612)1.89601686
74Hypoplasia of the fovea (HP:0007750)1.88192448
75Aplasia/Hypoplasia of the fovea (HP:0008060)1.88192448
76Furrowed tongue (HP:0000221)1.88040934
77Abnormality of the phalanges of the 5th finger (HP:0004213)1.85131229
78Abnormal hair whorl (HP:0010721)1.84413472
79Abnormality of the umbilical cord (HP:0010881)1.84232102
80Congenital sensorineural hearing impairment (HP:0008527)1.84059974
81Anomalous pulmonary venous return (HP:0010772)1.82157841
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81307642
83Abnormality of alanine metabolism (HP:0010916)1.81307642
84Hyperalaninemia (HP:0003348)1.81307642
85Methylmalonic aciduria (HP:0012120)1.81216438
86Hypoproteinemia (HP:0003075)1.80928362
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80927639
88Posterior subcapsular cataract (HP:0007787)1.79919344
89Abnormality of the fetal cardiovascular system (HP:0010948)1.77355304
90Abnormal umbilical cord blood vessels (HP:0011403)1.77355304
91Single umbilical artery (HP:0001195)1.77355304
92Septo-optic dysplasia (HP:0100842)1.76779146
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.74972432
94Intellectual disability, moderate (HP:0002342)1.73599292
95Short thumb (HP:0009778)1.73229896
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.72708475
97Oligohydramnios (HP:0001562)1.72675761
98Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70615011
99Hypoplasia of the uterus (HP:0000013)1.67690401
100Severe combined immunodeficiency (HP:0004430)1.66296705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B7.06423013
2MUSK4.68093973
3TIE14.32558333
4AKT33.57232063
5GRK13.13849650
6PNCK2.44564146
7ADRBK22.40525699
8STK38L2.26159705
9BUB12.18962361
10TLK12.14449446
11TAOK31.93183772
12PINK11.90353345
13PAK31.84181691
14KDR1.79414920
15STK241.72843924
16MAPK151.72315466
17PRKD21.68896633
18PLK21.67501694
19CASK1.31049409
20VRK11.26787054
21PRKCH1.26685529
22DYRK21.25596830
23CDC71.17336134
24ABL21.16868891
25PAK21.16337765
26TXK1.14581604
27FRK1.13123821
28MAP2K71.10963189
29WEE11.09561247
30BRAF1.07851559
31VRK21.00799963
32TAF10.96732393
33PRKCQ0.96507307
34IKBKB0.94932988
35NTRK30.93604581
36PRKCG0.92285056
37MAP3K40.88520605
38PRKCI0.86029787
39TNIK0.84312879
40ITK0.80924190
41PRKG20.76796298
42NUAK10.76752624
43GRK50.75497389
44CSK0.73678978
45ERBB20.72246206
46ADRBK10.71228797
47INSRR0.69880150
48MAP3K100.69732213
49GRK60.68728491
50TESK20.68557713
51MAP2K60.67318000
52TEC0.67051686
53AURKA0.66652395
54DDR20.64777964
55CAMK2A0.61748135
56PRKCE0.61004826
57MAPK130.60719202
58MAPK40.60482254
59IGF1R0.60432867
60STK380.60002312
61CSNK1A1L0.58052403
62MAPKAPK50.57725469
63CSNK1G30.57593702
64ZAK0.57314459
65WNK30.56488480
66PHKG10.51395407
67PHKG20.51395407
68PRKACA0.51165036
69FES0.50591206
70PRKD10.50450119
71ACVR1B0.50342965
72WNK40.50089371
73STK40.48188519
74CDK50.47581045
75CSNK1A10.47372845
76BCKDK0.46954992
77CSNK1G20.46509678
78KIT0.45777362
79PLK40.43580867
80CSNK1G10.42869832
81PRKCA0.42039371
82CDK80.41963641
83PTK2B0.39574164
84TNK20.39118258
85SGK4940.38950260
86SGK2230.38950260
87CAMK2B0.38223314
88MAP4K10.34890788
89CSNK2A10.34655644
90JAK30.32748727
91PLK10.31817966
92SGK20.31172146
93GSK3A0.30192790
94PRKCD0.29833021
95OXSR10.29822845
96FGFR10.29168011
97CAMK2D0.28671080
98PIM20.27336694
99EPHA40.27006846
100STK390.26881816

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.52976633
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.50633259
3Oxidative phosphorylation_Homo sapiens_hsa001903.21503216
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.12905755
5Protein export_Homo sapiens_hsa030602.96236380
6Parkinsons disease_Homo sapiens_hsa050122.67541565
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53893158
8Nicotine addiction_Homo sapiens_hsa050332.39909052
9Sulfur metabolism_Homo sapiens_hsa009202.29245115
10Vitamin B6 metabolism_Homo sapiens_hsa007502.15921915
11Alzheimers disease_Homo sapiens_hsa050102.06665685
12Selenocompound metabolism_Homo sapiens_hsa004501.95637038
13Primary immunodeficiency_Homo sapiens_hsa053401.93904261
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90421002
15Ribosome_Homo sapiens_hsa030101.88132982
16Basal cell carcinoma_Homo sapiens_hsa052171.80227258
17Basal transcription factors_Homo sapiens_hsa030221.78990071
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72253597
19Homologous recombination_Homo sapiens_hsa034401.68066229
20Huntingtons disease_Homo sapiens_hsa050161.56350714
21Pentose phosphate pathway_Homo sapiens_hsa000301.45285897
22Tryptophan metabolism_Homo sapiens_hsa003801.42143903
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.39672582
24Cardiac muscle contraction_Homo sapiens_hsa042601.38254043
25Chemical carcinogenesis_Homo sapiens_hsa052041.24833076
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23792617
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22719141
28Long-term depression_Homo sapiens_hsa047301.22457653
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19907351
30Phototransduction_Homo sapiens_hsa047441.15517995
31Morphine addiction_Homo sapiens_hsa050321.13637145
32Peroxisome_Homo sapiens_hsa041461.11324812
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06552013
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.06244168
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.04511599
36Nucleotide excision repair_Homo sapiens_hsa034201.02142123
37Insulin secretion_Homo sapiens_hsa049110.99541465
38Melanoma_Homo sapiens_hsa052180.98507922
39Vitamin digestion and absorption_Homo sapiens_hsa049770.96886852
40Rheumatoid arthritis_Homo sapiens_hsa053230.90569829
41Linoleic acid metabolism_Homo sapiens_hsa005910.89724905
42Serotonergic synapse_Homo sapiens_hsa047260.86490371
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85189057
44Mineral absorption_Homo sapiens_hsa049780.84358896
45Graft-versus-host disease_Homo sapiens_hsa053320.82824130
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82412083
47Renin secretion_Homo sapiens_hsa049240.80792497
48Glutamatergic synapse_Homo sapiens_hsa047240.80217518
49Olfactory transduction_Homo sapiens_hsa047400.80106479
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77530565
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74632284
52Fanconi anemia pathway_Homo sapiens_hsa034600.73590867
53Nitrogen metabolism_Homo sapiens_hsa009100.73076603
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72823487
55Calcium signaling pathway_Homo sapiens_hsa040200.72579382
56Circadian entrainment_Homo sapiens_hsa047130.72403318
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71981426
58GABAergic synapse_Homo sapiens_hsa047270.71061935
59Systemic lupus erythematosus_Homo sapiens_hsa053220.70900263
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.70860676
61Taste transduction_Homo sapiens_hsa047420.67739942
62Cocaine addiction_Homo sapiens_hsa050300.65550823
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.64918661
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63149260
65Steroid biosynthesis_Homo sapiens_hsa001000.62407906
66Asthma_Homo sapiens_hsa053100.61093112
67Hippo signaling pathway_Homo sapiens_hsa043900.58555901
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58307473
69Ras signaling pathway_Homo sapiens_hsa040140.57817334
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56050821
71Autoimmune thyroid disease_Homo sapiens_hsa053200.55188491
72Salivary secretion_Homo sapiens_hsa049700.53682123
73Synaptic vesicle cycle_Homo sapiens_hsa047210.53199953
74cAMP signaling pathway_Homo sapiens_hsa040240.52404933
75Renin-angiotensin system_Homo sapiens_hsa046140.51842489
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50764420
77Retinol metabolism_Homo sapiens_hsa008300.50624112
78Glycerolipid metabolism_Homo sapiens_hsa005610.50234565
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.50165898
80Rap1 signaling pathway_Homo sapiens_hsa040150.49280428
81T cell receptor signaling pathway_Homo sapiens_hsa046600.48153751
82Collecting duct acid secretion_Homo sapiens_hsa049660.48113886
83Fatty acid elongation_Homo sapiens_hsa000620.47076603
84TGF-beta signaling pathway_Homo sapiens_hsa043500.45555417
85N-Glycan biosynthesis_Homo sapiens_hsa005100.43530453
86Alcoholism_Homo sapiens_hsa050340.40947067
87MAPK signaling pathway_Homo sapiens_hsa040100.40710372
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40189304
89Cholinergic synapse_Homo sapiens_hsa047250.39866034
90Pathways in cancer_Homo sapiens_hsa052000.36321446
91Hematopoietic cell lineage_Homo sapiens_hsa046400.34894371
92Allograft rejection_Homo sapiens_hsa053300.34549447
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33775754
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33683921
95Fat digestion and absorption_Homo sapiens_hsa049750.32844947
96Metabolic pathways_Homo sapiens_hsa011000.32836675
97Wnt signaling pathway_Homo sapiens_hsa043100.32745549
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32228662
99Dopaminergic synapse_Homo sapiens_hsa047280.31917556
100Hedgehog signaling pathway_Homo sapiens_hsa043400.28256547

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