OR7E59P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)4.82479973
2response to pheromone (GO:0019236)4.27617762
3detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.20326196
4auditory receptor cell stereocilium organization (GO:0060088)4.13284752
5DNA deamination (GO:0045006)3.83488358
6negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.80155802
7negative regulation of T-helper cell differentiation (GO:0045623)3.80155802
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.71227146
9regulation of MHC class II biosynthetic process (GO:0045346)3.68603354
10heme transport (GO:0015886)3.64206419
11regulation of meiosis I (GO:0060631)3.60533357
12righting reflex (GO:0060013)3.59059882
13sphingosine metabolic process (GO:0006670)3.55237150
14reciprocal meiotic recombination (GO:0007131)3.46730449
15reciprocal DNA recombination (GO:0035825)3.46730449
16regulation of isotype switching to IgG isotypes (GO:0048302)3.40827825
17positive regulation of DNA recombination (GO:0045911)3.36801413
18L-fucose catabolic process (GO:0042355)3.35676814
19fucose catabolic process (GO:0019317)3.35676814
20L-fucose metabolic process (GO:0042354)3.35676814
21behavioral response to ethanol (GO:0048149)3.32834119
22positive regulation of granulocyte differentiation (GO:0030854)3.31842249
23positive regulation of mitotic sister chromatid separation (GO:1901970)3.27178983
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.27178983
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.27178983
26photoreceptor cell maintenance (GO:0045494)3.26534353
27sphingoid metabolic process (GO:0046519)3.22718281
28resolution of meiotic recombination intermediates (GO:0000712)3.21778298
29piRNA metabolic process (GO:0034587)3.19370092
30regulation of macrophage activation (GO:0043030)3.18835407
31negative regulation of alpha-beta T cell differentiation (GO:0046639)3.16548448
32DNA double-strand break processing (GO:0000729)3.16096120
33positive regulation of macrophage activation (GO:0043032)3.15490522
34recombinational repair (GO:0000725)3.14730298
35double-strand break repair via homologous recombination (GO:0000724)3.12817983
36detection of light stimulus involved in sensory perception (GO:0050962)3.04370073
37detection of light stimulus involved in visual perception (GO:0050908)3.04370073
38inner ear receptor stereocilium organization (GO:0060122)3.00835419
39regulation of hippo signaling (GO:0035330)3.00165813
40synapsis (GO:0007129)2.99786983
41regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97939520
42diol metabolic process (GO:0034311)2.97909502
43negative regulation of DNA-dependent DNA replication (GO:2000104)2.97728145
44positive regulation of mitochondrial fission (GO:0090141)2.95477345
45cell wall macromolecule catabolic process (GO:0016998)2.94235392
46neural tube formation (GO:0001841)2.93674479
47ether lipid metabolic process (GO:0046485)2.93097036
48meiotic chromosome segregation (GO:0045132)2.91541484
49positive regulation of organelle assembly (GO:1902117)2.91044332
50regulation of chronic inflammatory response (GO:0002676)2.90996058
51reflex (GO:0060004)2.90944846
52positive regulation of isotype switching (GO:0045830)2.89699266
53DNA replication-dependent nucleosome organization (GO:0034723)2.87196801
54DNA replication-dependent nucleosome assembly (GO:0006335)2.87196801
55regulation of sarcomere organization (GO:0060297)2.86644111
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83789099
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.75269109
58regulation of rhodopsin mediated signaling pathway (GO:0022400)2.71844930
59indolalkylamine metabolic process (GO:0006586)2.71803043
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.66795290
61CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.65615221
62parental behavior (GO:0060746)2.65110729
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64415908
64cellular response to sterol (GO:0036315)2.63794707
65histone mRNA catabolic process (GO:0071044)2.63454388
66centriole replication (GO:0007099)2.63332112
67positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.61870714
68retinal cone cell development (GO:0046549)2.59297234
69cellular ketone body metabolic process (GO:0046950)2.58776854
70CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.57107914
71T-helper cell differentiation (GO:0042093)2.57107914
72seminiferous tubule development (GO:0072520)2.54610350
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54332370
74rhodopsin mediated signaling pathway (GO:0016056)2.53699761
75proline transport (GO:0015824)2.53067690
76attachment of spindle microtubules to kinetochore (GO:0008608)2.52812296
77male meiosis (GO:0007140)2.51951258
78protein K11-linked deubiquitination (GO:0035871)2.51613543
79nucleotide transmembrane transport (GO:1901679)2.51503313
80positive regulation of developmental pigmentation (GO:0048087)2.51243380
81inositol phosphate catabolic process (GO:0071545)2.51171551
82cell wall macromolecule metabolic process (GO:0044036)2.50775381
83microtubule anchoring (GO:0034453)2.50443973
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.49953824
85positive regulation of protein homodimerization activity (GO:0090073)2.48942351
86histone H2A acetylation (GO:0043968)2.48829351
87positive regulation of cell cycle G1/S phase transition (GO:1902808)2.48552679
88adaptation of signaling pathway (GO:0023058)2.47904341
89histone H3-K9 methylation (GO:0051567)2.47093091
90behavioral response to nicotine (GO:0035095)2.45098319
91brain morphogenesis (GO:0048854)2.43937537
92regulation of cilium movement (GO:0003352)2.43543390
93cytokine biosynthetic process (GO:0042089)2.42875968
94negative regulation of acute inflammatory response (GO:0002674)2.42324857
95double-strand break repair via nonhomologous end joining (GO:0006303)2.42264602
96non-recombinational repair (GO:0000726)2.42264602
97coenzyme catabolic process (GO:0009109)2.41638082
98ketone body metabolic process (GO:1902224)2.41566539
99DNA methylation involved in gamete generation (GO:0043046)2.40735362
100hepatocyte apoptotic process (GO:0097284)2.40658225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.28284473
2GBX2_23144817_ChIP-Seq_PC3_Human3.15632975
3ZNF274_21170338_ChIP-Seq_K562_Hela3.00786316
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74216747
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.72039182
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67286775
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.65151760
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58642069
9TAF15_26573619_Chip-Seq_HEK293_Human2.43822148
10IGF1R_20145208_ChIP-Seq_DFB_Human2.37303304
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35118367
12FUS_26573619_Chip-Seq_HEK293_Human2.31289357
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20037964
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12484575
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08968394
16EWS_26573619_Chip-Seq_HEK293_Human2.05794028
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02208355
18P300_19829295_ChIP-Seq_ESCs_Human2.00391011
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94020773
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89512958
21ER_23166858_ChIP-Seq_MCF-7_Human1.88456425
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85242531
23BCAT_22108803_ChIP-Seq_LS180_Human1.83154297
24ELK1_19687146_ChIP-ChIP_HELA_Human1.83027127
25CBP_20019798_ChIP-Seq_JUKART_Human1.81864879
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.81864879
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79930183
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.79435442
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77027631
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.75233116
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74400240
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70107907
33IRF1_19129219_ChIP-ChIP_H3396_Human1.67529259
34STAT3_23295773_ChIP-Seq_U87_Human1.65441046
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65237094
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62092193
37TCF4_23295773_ChIP-Seq_U87_Human1.59622372
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.58309460
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.56803110
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53800272
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50859739
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50632554
43SOX2_19829295_ChIP-Seq_ESCs_Human1.48013869
44NANOG_19829295_ChIP-Seq_ESCs_Human1.48013869
45SMAD4_21799915_ChIP-Seq_A2780_Human1.46019542
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.44385841
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43107019
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42631229
49TP53_22573176_ChIP-Seq_HFKS_Human1.40635378
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40378105
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.38564710
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.38345121
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37404738
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37404738
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36452097
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.34464406
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34214603
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.33662595
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33582668
60TCF4_22108803_ChIP-Seq_LS180_Human1.33363306
61CDX2_22108803_ChIP-Seq_LS180_Human1.33274563
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33033801
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.32701738
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.32333159
65AR_25329375_ChIP-Seq_VCAP_Human1.32323491
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31918185
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30561390
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29175788
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26485977
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25827547
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24410396
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23794899
73P53_22387025_ChIP-Seq_ESCs_Mouse1.23107727
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.22058035
75MYC_18940864_ChIP-ChIP_HL60_Human1.19044536
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18652355
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18468365
78VDR_23849224_ChIP-Seq_CD4+_Human1.18059302
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.15980265
80RUNX2_22187159_ChIP-Seq_PCA_Human1.15717339
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.14661937
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.14524093
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09750528
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.09608418
85P300_18555785_Chip-Seq_ESCs_Mouse1.09270231
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07727227
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05259255
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.04384812
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04384812
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.04197962
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03261117
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.01892733
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01773560
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00121827
95OCT4_18555785_Chip-Seq_ESCs_Mouse0.99897045
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99753366
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99249510
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98915270
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98813032
100FOXP3_21729870_ChIP-Seq_TREG_Human0.98770559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.18584769
2MP0008057_abnormal_DNA_replication3.79541310
3MP0003787_abnormal_imprinting3.11297300
4MP0000569_abnormal_digit_pigmentation2.79708510
5MP0006292_abnormal_olfactory_placode2.73478450
6MP0008872_abnormal_physiological_respon2.63169457
7MP0003195_calcinosis2.61521431
8MP0003045_fibrosis2.56506776
9MP0002254_reproductive_system_inflammat2.56324533
10MP0001348_abnormal_lacrimal_gland2.54598174
11MP0008875_abnormal_xenobiotic_pharmacok2.49092916
12MP0002837_dystrophic_cardiac_calcinosis2.36873882
13MP0005646_abnormal_pituitary_gland2.36027161
14MP0002102_abnormal_ear_morphology2.22329693
15MP0001873_stomach_inflammation2.20931977
16MP0005551_abnormal_eye_electrophysiolog2.06083473
17MP0003718_maternal_effect1.99886236
18MP0003880_abnormal_central_pattern1.96894632
19MP0003950_abnormal_plasma_membrane1.94243643
20MP0005670_abnormal_white_adipose1.93457372
21MP0001968_abnormal_touch/_nociception1.89652649
22MP0004147_increased_porphyrin_level1.84186749
23MP0001501_abnormal_sleep_pattern1.80864004
24MP0001986_abnormal_taste_sensitivity1.78375380
25MP0000372_irregular_coat_pigmentation1.73411633
26MP0005084_abnormal_gallbladder_morpholo1.65822937
27MP0008775_abnormal_heart_ventricle1.64164180
28MP0008058_abnormal_DNA_repair1.61594893
29MP0000427_abnormal_hair_cycle1.61072131
30MP0001984_abnormal_olfaction1.59721352
31MP0003136_yellow_coat_color1.57182691
32MP0001486_abnormal_startle_reflex1.57000500
33MP0005367_renal/urinary_system_phenotyp1.54797359
34MP0000516_abnormal_urinary_system1.54797359
35MP0004084_abnormal_cardiac_muscle1.48811526
36MP0002938_white_spotting1.46465906
37MP0009046_muscle_twitch1.45898544
38MP0005253_abnormal_eye_physiology1.41353449
39MP0003121_genomic_imprinting1.39206275
40MP0005395_other_phenotype1.36946410
41MP0004742_abnormal_vestibular_system1.32855821
42MP0005174_abnormal_tail_pigmentation1.32666824
43MP0005075_abnormal_melanosome_morpholog1.29414809
44MP0009745_abnormal_behavioral_response1.28842785
45MP0002736_abnormal_nociception_after1.26976479
46MP0005171_absent_coat_pigmentation1.26509593
47MP0005310_abnormal_salivary_gland1.25873405
48MP0002168_other_aberrant_phenotype1.23985244
49MP0006072_abnormal_retinal_apoptosis1.17871999
50MP0005645_abnormal_hypothalamus_physiol1.16919644
51MP0004484_altered_response_of1.15552012
52MP0004215_abnormal_myocardial_fiber1.15547445
53MP0002876_abnormal_thyroid_physiology1.07583986
54MP0005410_abnormal_fertilization1.05796441
55MP0004043_abnormal_pH_regulation1.03925748
56MP0002160_abnormal_reproductive_system1.02842410
57MP0000631_abnormal_neuroendocrine_gland1.02124915
58MP0001764_abnormal_homeostasis1.00124404
59MP0003646_muscle_fatigue0.99569611
60MP0003786_premature_aging0.99247647
61MP0004142_abnormal_muscle_tone0.98084101
62MP0006035_abnormal_mitochondrial_morpho0.96779494
63MP0006036_abnormal_mitochondrial_physio0.95259528
64MP0003806_abnormal_nucleotide_metabolis0.95204867
65MP0003698_abnormal_male_reproductive0.93386541
66MP0002751_abnormal_autonomic_nervous0.91930921
67MP0008995_early_reproductive_senescence0.91109021
68MP0002138_abnormal_hepatobiliary_system0.90867356
69MP0001545_abnormal_hematopoietic_system0.90559227
70MP0005397_hematopoietic_system_phenotyp0.90559227
71MP0005085_abnormal_gallbladder_physiolo0.89541415
72MP0002210_abnormal_sex_determination0.88785171
73MP0001929_abnormal_gametogenesis0.87708726
74MP0003252_abnormal_bile_duct0.87176760
75MP0002557_abnormal_social/conspecific_i0.86248621
76MP0005360_urolithiasis0.86095799
77MP0000653_abnormal_sex_gland0.82341112
78MP0009780_abnormal_chondrocyte_physiolo0.81009970
79MP0001485_abnormal_pinna_reflex0.80991713
80MP0005386_behavior/neurological_phenoty0.80362486
81MP0004924_abnormal_behavior0.80362486
82MP0006054_spinal_hemorrhage0.80135140
83MP0005636_abnormal_mineral_homeostasis0.79901882
84MP0002396_abnormal_hematopoietic_system0.79675345
85MP0002735_abnormal_chemical_nociception0.78637077
86MP0001145_abnormal_male_reproductive0.78315505
87MP0001835_abnormal_antigen_presentation0.77561548
88MP0002272_abnormal_nervous_system0.77202600
89MP0010094_abnormal_chromosome_stability0.76642240
90MP0005389_reproductive_system_phenotype0.74875917
91MP0002572_abnormal_emotion/affect_behav0.74074810
92MP0005379_endocrine/exocrine_gland_phen0.73508805
93MP0009764_decreased_sensitivity_to0.72556383
94MP0001119_abnormal_female_reproductive0.72450377
95MP0002234_abnormal_pharynx_morphology0.70356295
96MP0002064_seizures0.67580841
97MP0002229_neurodegeneration0.66988627
98MP0002009_preneoplasia0.66711988
99MP0003943_abnormal_hepatobiliary_system0.66509130
100MP0004885_abnormal_endolymph0.65092428

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.21578404
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.19178085
3Pancreatic cysts (HP:0001737)3.97780841
4Focal motor seizures (HP:0011153)3.72462225
5Abnormal rod and cone electroretinograms (HP:0008323)3.67695505
6Congenital stationary night blindness (HP:0007642)3.62093673
7Pancreatic fibrosis (HP:0100732)3.55676512
8Attenuation of retinal blood vessels (HP:0007843)3.47008423
9Nephronophthisis (HP:0000090)3.45619889
10Hypochromic microcytic anemia (HP:0004840)3.39921509
11Decreased central vision (HP:0007663)3.14365807
12True hermaphroditism (HP:0010459)3.11067706
13Abnormality of macular pigmentation (HP:0008002)3.04439139
14Abnormality of the renal medulla (HP:0100957)3.01604905
15Abnormality of the renal cortex (HP:0011035)2.85396164
16Type II lissencephaly (HP:0007260)2.83165123
17Abnormality of midbrain morphology (HP:0002418)2.76689380
18Molar tooth sign on MRI (HP:0002419)2.76689380
19Intestinal atresia (HP:0011100)2.63816497
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.59097277
21Focal seizures (HP:0007359)2.50274656
22Gaze-evoked nystagmus (HP:0000640)2.49618554
23Tubular atrophy (HP:0000092)2.49321508
24Thyroiditis (HP:0100646)2.48401772
25Thyroid-stimulating hormone excess (HP:0002925)2.47500594
26Stomatitis (HP:0010280)2.45913093
27Methylmalonic aciduria (HP:0012120)2.45701742
28Cystic liver disease (HP:0006706)2.42173616
29Papilledema (HP:0001085)2.38430751
30Chronic hepatic failure (HP:0100626)2.37061852
31Ependymoma (HP:0002888)2.36279141
32Cerebellar dysplasia (HP:0007033)2.26848798
33Colon cancer (HP:0003003)2.25279561
34Short tibia (HP:0005736)2.24086654
35Central scotoma (HP:0000603)2.23720469
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.23675903
37Constricted visual fields (HP:0001133)2.19694482
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.18090923
39Abnormality of chromosome stability (HP:0003220)2.16435593
40Absent speech (HP:0001344)2.15477922
41Large for gestational age (HP:0001520)2.14860265
42Follicular hyperkeratosis (HP:0007502)2.14304883
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.13809263
44Tubulointerstitial nephritis (HP:0001970)2.13560057
45Increased corneal curvature (HP:0100692)2.13520835
46Keratoconus (HP:0000563)2.13520835
47Pendular nystagmus (HP:0012043)2.10701940
48Renal cortical cysts (HP:0000803)2.09767668
49Sloping forehead (HP:0000340)2.07998301
50Abolished electroretinogram (ERG) (HP:0000550)2.07144712
51Bulbous nose (HP:0000414)2.04604919
52Hemiparesis (HP:0001269)2.02867633
53Limb hypertonia (HP:0002509)2.01054813
54Medial flaring of the eyebrow (HP:0010747)2.00594566
55Astrocytoma (HP:0009592)1.99835370
56Abnormality of the astrocytes (HP:0100707)1.99835370
57Dialeptic seizures (HP:0011146)1.99165187
58Congenital hepatic fibrosis (HP:0002612)1.99054928
59Asplenia (HP:0001746)1.98944397
60Postaxial foot polydactyly (HP:0001830)1.97910706
61Abnormality of the ileum (HP:0001549)1.97682464
62Disproportionate short-trunk short stature (HP:0003521)1.95313369
63Widely spaced teeth (HP:0000687)1.93275029
64Dyschromatopsia (HP:0007641)1.91542957
65Bile duct proliferation (HP:0001408)1.90521535
66Abnormal biliary tract physiology (HP:0012439)1.90521535
67Autoimmune hemolytic anemia (HP:0001890)1.88930588
68Delayed CNS myelination (HP:0002188)1.88192699
69Partial agenesis of the corpus callosum (HP:0001338)1.87682058
70Albinism (HP:0001022)1.86221645
71Broad-based gait (HP:0002136)1.86199360
72Lissencephaly (HP:0001339)1.84802454
73Congenital sensorineural hearing impairment (HP:0008527)1.84771439
74Polydipsia (HP:0001959)1.83674887
75Abnormal drinking behavior (HP:0030082)1.83674887
76Meckel diverticulum (HP:0002245)1.82520295
77Progressive microcephaly (HP:0000253)1.81954331
78Dysdiadochokinesis (HP:0002075)1.80851392
79Bony spicule pigmentary retinopathy (HP:0007737)1.80098220
80Volvulus (HP:0002580)1.79703136
81Inability to walk (HP:0002540)1.78320525
82Febrile seizures (HP:0002373)1.77593595
83Metaphyseal dysplasia (HP:0100255)1.77500949
84Methylmalonic acidemia (HP:0002912)1.76437396
85Tented upper lip vermilion (HP:0010804)1.76274130
86Hypothermia (HP:0002045)1.75081467
87Abnormality of the labia minora (HP:0012880)1.74515762
88Progressive inability to walk (HP:0002505)1.72424804
89Panhypogammaglobulinemia (HP:0003139)1.72424132
90Hypoproteinemia (HP:0003075)1.69085314
91Fibular aplasia (HP:0002990)1.68252334
92Anencephaly (HP:0002323)1.67091435
93Tubulointerstitial abnormality (HP:0001969)1.66237400
94Astigmatism (HP:0000483)1.65554131
95IgG deficiency (HP:0004315)1.65504650
96Glioma (HP:0009733)1.64931770
97Macular degeneration (HP:0000608)1.64114238
98Neoplasm of the adrenal cortex (HP:0100641)1.63909918
99Decreased circulating renin level (HP:0003351)1.62303186
100Posterior subcapsular cataract (HP:0007787)1.62111007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.59929056
2PBK3.57995735
3BRD42.81086853
4ADRBK22.78433909
5TAOK32.62978952
6EIF2AK32.36765236
7BMPR1B2.35783742
8NUAK12.22525295
9STK38L2.13346826
10PIK3CG2.08264515
11PINK12.05194952
12BRSK22.02749541
13MAP3K41.94665455
14MKNK21.90811608
15EIF2AK11.83671754
16WNK31.76002071
17TRIM281.68406963
18WEE11.55320933
19MAP4K21.53461059
20STK31.52810876
21AKT31.52484810
22GRK11.40491226
23CASK1.39414750
24PNCK1.39291319
25TXK1.39020286
26MAPK131.37469397
27IRAK11.34683575
28LATS11.33131683
29STK391.31946679
30PLK31.31630921
31TNIK1.26733794
32ACVR1B1.26451252
33OXSR11.20982944
34FGFR21.19153191
35MST41.18959518
36ZAK1.17091916
37MAP2K71.16590322
38VRK21.13470045
39MKNK11.11861724
40EIF2AK21.02886492
41INSRR1.02092123
42NME11.01240804
43BMPR20.99915582
44PLK20.93428264
45ERBB30.91180590
46CCNB10.90680281
47PRKCE0.88271490
48VRK10.85797817
49DAPK20.85307163
50PAK30.84524123
51TSSK60.83812631
52DYRK30.78864862
53STK240.75356162
54CSNK1G10.74990141
55TEC0.72817593
56TGFBR10.70733171
57ADRBK10.70155490
58PTK2B0.69880716
59NLK0.69308083
60WNK40.67427944
61ITK0.66395390
62CSNK1G20.65518679
63EPHA40.65202654
64CSNK1A1L0.65012840
65CSNK1G30.64585856
66GRK70.62678641
67STK40.59391785
68CDK30.59339177
69RPS6KA40.58873012
70NEK60.58813147
71KIT0.57940690
72IKBKB0.56257866
73TIE10.50606704
74PRKCG0.48428791
75ATM0.48138323
76MAP2K40.45134177
77MARK10.44936839
78CAMKK20.44898135
79PHKG20.44044869
80PHKG10.44044869
81SGK20.43740445
82MAP3K50.43192392
83CAMK2A0.38694962
84CDK80.35798490
85BCKDK0.35747084
86BCR0.34287491
87IRAK40.34072882
88IGF1R0.34072033
89CSNK1D0.33411320
90FGFR30.32795208
91CSNK1A10.32628911
92CHEK20.32158291
93TNK20.31335592
94RPS6KA50.30884076
95GRK50.30235581
96ATR0.27943727
97SGK30.26853059
98CLK10.26145724
99PRKCQ0.25452701
100TTK0.24437376

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23662162
2Non-homologous end-joining_Homo sapiens_hsa034502.91124125
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.85326587
4Phototransduction_Homo sapiens_hsa047442.81995782
5Basal transcription factors_Homo sapiens_hsa030222.76383802
6Selenocompound metabolism_Homo sapiens_hsa004502.34562488
7Asthma_Homo sapiens_hsa053102.32241490
8Butanoate metabolism_Homo sapiens_hsa006502.22044809
9Fanconi anemia pathway_Homo sapiens_hsa034602.21699397
10Homologous recombination_Homo sapiens_hsa034402.20295331
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17255426
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.17102841
13Protein export_Homo sapiens_hsa030602.08305192
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05975498
15RNA polymerase_Homo sapiens_hsa030202.03831647
16Propanoate metabolism_Homo sapiens_hsa006402.02424131
17Allograft rejection_Homo sapiens_hsa053301.90677446
18Nitrogen metabolism_Homo sapiens_hsa009101.85171345
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74849897
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70404615
21Olfactory transduction_Homo sapiens_hsa047401.69839305
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67638336
23Autoimmune thyroid disease_Homo sapiens_hsa053201.63168280
24Taste transduction_Homo sapiens_hsa047421.54146524
25One carbon pool by folate_Homo sapiens_hsa006701.54083584
26Mismatch repair_Homo sapiens_hsa034301.42025640
27RNA degradation_Homo sapiens_hsa030181.38729324
28ABC transporters_Homo sapiens_hsa020101.38074549
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33370291
30Tryptophan metabolism_Homo sapiens_hsa003801.24583001
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24392835
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23122421
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.19479124
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.16292174
35Nucleotide excision repair_Homo sapiens_hsa034201.13924539
36Sphingolipid metabolism_Homo sapiens_hsa006001.13406882
37Circadian entrainment_Homo sapiens_hsa047131.10471611
38Nicotine addiction_Homo sapiens_hsa050331.09536381
39Linoleic acid metabolism_Homo sapiens_hsa005911.08430904
40RNA transport_Homo sapiens_hsa030131.06449255
41Renin secretion_Homo sapiens_hsa049241.02436996
42Peroxisome_Homo sapiens_hsa041460.98115983
43Dorso-ventral axis formation_Homo sapiens_hsa043200.97899841
44Salivary secretion_Homo sapiens_hsa049700.94966595
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93469603
46Morphine addiction_Homo sapiens_hsa050320.91369489
47Steroid biosynthesis_Homo sapiens_hsa001000.90257321
48Purine metabolism_Homo sapiens_hsa002300.89231630
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88956777
50Caffeine metabolism_Homo sapiens_hsa002320.87756714
51Proteasome_Homo sapiens_hsa030500.86866355
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84896420
53Calcium signaling pathway_Homo sapiens_hsa040200.84759156
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84689773
55Serotonergic synapse_Homo sapiens_hsa047260.73183356
56Vitamin B6 metabolism_Homo sapiens_hsa007500.72688309
57Chemical carcinogenesis_Homo sapiens_hsa052040.72350363
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72223801
59Collecting duct acid secretion_Homo sapiens_hsa049660.69503579
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68957199
61Circadian rhythm_Homo sapiens_hsa047100.67772180
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67430092
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.67047624
64Hematopoietic cell lineage_Homo sapiens_hsa046400.66740135
65Glutamatergic synapse_Homo sapiens_hsa047240.65235989
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64903459
67Glycerolipid metabolism_Homo sapiens_hsa005610.63661182
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61831399
69Primary immunodeficiency_Homo sapiens_hsa053400.59973320
70mRNA surveillance pathway_Homo sapiens_hsa030150.59370871
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55451979
72Dopaminergic synapse_Homo sapiens_hsa047280.54494776
73Retinol metabolism_Homo sapiens_hsa008300.53722973
74GABAergic synapse_Homo sapiens_hsa047270.53037111
75Ether lipid metabolism_Homo sapiens_hsa005650.49389061
76Pyrimidine metabolism_Homo sapiens_hsa002400.49195471
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48864634
78Measles_Homo sapiens_hsa051620.48746587
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47687144
80Vitamin digestion and absorption_Homo sapiens_hsa049770.46071930
81T cell receptor signaling pathway_Homo sapiens_hsa046600.45455218
82Arachidonic acid metabolism_Homo sapiens_hsa005900.45348500
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.45305059
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44410894
85Ovarian steroidogenesis_Homo sapiens_hsa049130.44315680
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44023612
87Long-term depression_Homo sapiens_hsa047300.40799130
88Metabolic pathways_Homo sapiens_hsa011000.40279289
89Lysine degradation_Homo sapiens_hsa003100.39854297
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39492311
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37552479
92Sulfur metabolism_Homo sapiens_hsa009200.36153289
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36088284
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35679526
95Fatty acid degradation_Homo sapiens_hsa000710.34275906
96Regulation of autophagy_Homo sapiens_hsa041400.33680583
97Insulin secretion_Homo sapiens_hsa049110.33178201
98Oocyte meiosis_Homo sapiens_hsa041140.32547577
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28052600
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27137592

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