OR7E66P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.59793726
2negative regulation by host of viral transcription (GO:0043922)7.95833860
3eosinophil chemotaxis (GO:0048245)6.59922979
4regulation of lymphocyte chemotaxis (GO:1901623)5.95192759
5eosinophil migration (GO:0072677)5.94477142
6negative regulation of T cell apoptotic process (GO:0070233)5.46715670
7regulation of activation of Janus kinase activity (GO:0010533)5.05366167
8regulation of mononuclear cell migration (GO:0071675)4.88768064
9negative regulation of T cell receptor signaling pathway (GO:0050860)4.84435860
10macrophage chemotaxis (GO:0048246)4.82626093
11pyrimidine nucleoside catabolic process (GO:0046135)4.64713372
12positive regulation of lymphocyte migration (GO:2000403)4.64155242
13cellular response to interleukin-15 (GO:0071350)4.61347686
14positive regulation of calcium-mediated signaling (GO:0050850)4.61039250
15positive regulation of T cell apoptotic process (GO:0070234)4.60268578
16regulation of chronic inflammatory response (GO:0002676)4.53119091
17regulation of T cell receptor signaling pathway (GO:0050856)4.51855149
18regulation of T cell tolerance induction (GO:0002664)4.45653132
19modulation by host of viral transcription (GO:0043921)4.40023535
20modulation by host of symbiont transcription (GO:0052472)4.40023535
21positive regulation of T cell chemotaxis (GO:0010820)4.34046166
22regulation of T cell chemotaxis (GO:0010819)4.34046166
23positive regulation of macrophage differentiation (GO:0045651)4.32824048
24protein neddylation (GO:0045116)4.31253510
25positive regulation of tolerance induction (GO:0002645)4.23019443
26modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.19097810
27Arp2/3 complex-mediated actin nucleation (GO:0034314)4.18253098
28negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.17191634
29negative regulation of viral genome replication (GO:0045071)4.09723979
30regulation of chemokine-mediated signaling pathway (GO:0070099)4.09510904
31regulation of macrophage chemotaxis (GO:0010758)4.08944317
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.04146676
33negative regulation of viral transcription (GO:0032897)3.94709622
34regulation of regulatory T cell differentiation (GO:0045589)3.85708279
35positive regulation of lymphocyte apoptotic process (GO:0070230)3.82044809
36proteasome assembly (GO:0043248)3.80963483
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.80768423
38negative regulation of T cell differentiation in thymus (GO:0033085)3.77492630
39positive regulation of interleukin-8 secretion (GO:2000484)3.77027766
40monocyte chemotaxis (GO:0002548)3.74820845
41positive T cell selection (GO:0043368)3.73115892
42regulation of T cell apoptotic process (GO:0070232)3.72535265
43negative regulation of lymphocyte apoptotic process (GO:0070229)3.69703270
44negative regulation of B cell proliferation (GO:0030889)3.66043344
45actin nucleation (GO:0045010)3.61551635
46regulation of B cell differentiation (GO:0045577)3.58149311
47regulation of tolerance induction (GO:0002643)3.47649547
48positive regulation of defense response to virus by host (GO:0002230)3.45097791
49regulation of cellular amino acid metabolic process (GO:0006521)3.44885651
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.43026688
51positive regulation of monocyte chemotaxis (GO:0090026)3.42711642
52regulation of calcium-mediated signaling (GO:0050848)3.38475803
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38085385
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.34230392
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33680182
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33680182
57regulation of lymphocyte migration (GO:2000401)3.28665963
58positive regulation of natural killer cell mediated immunity (GO:0002717)3.28155479
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26769048
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26769048
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26769048
62response to interleukin-15 (GO:0070672)3.20066808
63pyrimidine ribonucleoside metabolic process (GO:0046131)3.16041718
64negative regulation of B cell activation (GO:0050869)3.13594884
65positive regulation of cell cycle arrest (GO:0071158)3.13175240
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10243956
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09180836
68positive thymic T cell selection (GO:0045059)3.08928257
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08057983
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.08057983
71modification by host of symbiont morphology or physiology (GO:0051851)3.07005219
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05707483
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04136176
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.02589434
75negative regulation of ligase activity (GO:0051352)3.00504667
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00504667
77regulation of viral genome replication (GO:0045069)2.99536610
78purine deoxyribonucleotide catabolic process (GO:0009155)2.99049029
79positive regulation of T cell migration (GO:2000406)2.97545226
80negative T cell selection (GO:0043383)2.96729488
81regulation of lymphocyte apoptotic process (GO:0070228)2.93964045
82negative regulation of telomere maintenance (GO:0032205)2.88359814
83negative regulation of viral process (GO:0048525)2.86767608
84adaptation of signaling pathway (GO:0023058)2.84710335
85regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83232257
86regulation of natural killer cell mediated immunity (GO:0002715)2.83232257
87antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82309037
88regulation of alpha-beta T cell proliferation (GO:0046640)2.82284690
89T cell costimulation (GO:0031295)2.81540844
90interaction with symbiont (GO:0051702)2.79319964
91lymphocyte costimulation (GO:0031294)2.77919804
92regulation of B cell receptor signaling pathway (GO:0050855)2.77186311
93signal peptide processing (GO:0006465)2.77180328
94positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.75770033
95negative regulation of leukocyte apoptotic process (GO:2000107)2.74460323
96cytidine metabolic process (GO:0046087)11.2839740
97cytidine catabolic process (GO:0006216)11.2839740
98cytidine deamination (GO:0009972)11.2839740
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.8437481
100pyrimidine ribonucleoside catabolic process (GO:0046133)10.2538182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human3.96688314
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54340021
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48581103
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.29039211
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27091723
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.00149446
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.95147983
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64144454
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.59841305
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38328561
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19230656
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01292678
13BP1_19119308_ChIP-ChIP_Hs578T_Human13.1329693
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94564387
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88515941
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83687729
17VDR_23849224_ChIP-Seq_CD4+_Human1.83315160
18MYB_26560356_Chip-Seq_TH2_Human1.81212694
19VDR_22108803_ChIP-Seq_LS180_Human1.78890185
20TAF15_26573619_Chip-Seq_HEK293_Human1.74960055
21FOXP3_21729870_ChIP-Seq_TREG_Human1.74561455
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73933861
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.71867306
24ELK1_19687146_ChIP-ChIP_HELA_Human1.69418376
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66542516
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66441545
27ZNF274_21170338_ChIP-Seq_K562_Hela1.63780915
28HTT_18923047_ChIP-ChIP_STHdh_Human1.61282991
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49175126
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45631109
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45360124
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44309228
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.43293968
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.43255204
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41326605
36GATA3_26560356_Chip-Seq_TH2_Human1.41139124
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40372651
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40232280
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40136387
40GATA3_27048872_Chip-Seq_THYMUS_Human1.39661872
41RUNX_20019798_ChIP-Seq_JUKART_Human1.39397857
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36133871
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26712939
44IRF1_19129219_ChIP-ChIP_H3396_Human1.26313811
45TP53_22573176_ChIP-Seq_HFKS_Human1.22960242
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22599104
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.18724333
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.18143900
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14816676
50MYB_26560356_Chip-Seq_TH1_Human1.14479951
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14415687
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13648508
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08687141
54MYC_18940864_ChIP-ChIP_HL60_Human1.05916108
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.05259790
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04930241
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04656362
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04168222
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02559547
60BCAT_22108803_ChIP-Seq_LS180_Human0.97717168
61SOX2_19829295_ChIP-Seq_ESCs_Human0.97707140
62NANOG_19829295_ChIP-Seq_ESCs_Human0.97707140
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96976205
64NANOG_20526341_ChIP-Seq_ESCs_Human0.94716160
65EZH2_27294783_Chip-Seq_NPCs_Mouse0.93743124
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91954552
67FOXA1_25329375_ChIP-Seq_VCAP_Human0.90244012
68FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90244012
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88529939
70IRF8_21731497_ChIP-ChIP_J774_Mouse0.86989231
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86910630
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85713747
73AR_20517297_ChIP-Seq_VCAP_Human0.85691794
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84560008
75P300_19829295_ChIP-Seq_ESCs_Human0.83791195
76NOTCH1_21737748_ChIP-Seq_TLL_Human0.82006326
77CRX_20693478_ChIP-Seq_RETINA_Mouse0.80340719
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78388892
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78372493
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.77353200
81SPI1_23547873_ChIP-Seq_NB4_Human0.75753612
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.74349240
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.74185880
84UTX_26944678_Chip-Seq_JUKART_Human0.74136484
85OCT4_18555785_Chip-Seq_ESCs_Mouse0.74085580
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.73916213
87ERG_20517297_ChIP-Seq_VCAP_Human0.73867656
88NCOR_22424771_ChIP-Seq_293T_Human0.73175559
89GATA3_26560356_Chip-Seq_TH1_Human0.72262663
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72252054
91EWS_26573619_Chip-Seq_HEK293_Human0.72107093
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.71914431
93SMAD1_18555785_Chip-Seq_ESCs_Mouse0.71836240
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70991502
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.68320700
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.68267950
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68102967
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67991912
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.67504655
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67021416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.25899540
2MP0003763_abnormal_thymus_physiology3.73420261
3MP0001873_stomach_inflammation3.26849503
4MP0002837_dystrophic_cardiac_calcinosis3.24437566
5MP0000372_irregular_coat_pigmentation3.18858834
6MP0009333_abnormal_splenocyte_physiolog2.96982554
7MP0001188_hyperpigmentation2.53692588
8MP0002163_abnormal_gland_morphology2.48016053
9MP0002277_abnormal_respiratory_mucosa2.46884851
10MP0006082_CNS_inflammation2.46565420
11MP0004134_abnormal_chest_morphology2.41237974
12MP0003786_premature_aging2.37398239
13MP0003693_abnormal_embryo_hatching2.23949891
14MP0009785_altered_susceptibility_to2.22412846
15MP0001984_abnormal_olfaction2.21927522
16MP0002148_abnormal_hypersensitivity_rea2.09876071
17MP0005000_abnormal_immune_tolerance2.05374033
18MP0005379_endocrine/exocrine_gland_phen2.01213440
19MP0001919_abnormal_reproductive_system1.98040464
20MP0005075_abnormal_melanosome_morpholog1.88981072
21MP0002420_abnormal_adaptive_immunity1.81725260
22MP0001346_abnormal_lacrimal_gland1.74350268
23MP0001819_abnormal_immune_cell1.73906725
24MP0003866_abnormal_defecation1.70954169
25MP0002723_abnormal_immune_serum1.63987658
26MP0005387_immune_system_phenotype1.62681552
27MP0001790_abnormal_immune_system1.62681552
28MP0001853_heart_inflammation1.57989155
29MP0005389_reproductive_system_phenotype1.55994530
30MP0003136_yellow_coat_color1.55948801
31MP0001800_abnormal_humoral_immune1.55936182
32MP0003011_delayed_dark_adaptation1.55594699
33MP0004043_abnormal_pH_regulation1.54186360
34MP0005408_hypopigmentation1.51781905
35MP0002933_joint_inflammation1.51385836
36MP0000716_abnormal_immune_system1.50722276
37MP0002398_abnormal_bone_marrow1.47821091
38MP0002638_abnormal_pupillary_reflex1.45214429
39MP0004145_abnormal_muscle_electrophysio1.44120096
40MP0001835_abnormal_antigen_presentation1.43454313
41MP0004381_abnormal_hair_follicle1.41341591
42MP0001905_abnormal_dopamine_level1.41216545
43MP0003172_abnormal_lysosome_physiology1.39122658
44MP0005310_abnormal_salivary_gland1.38112887
45MP0000703_abnormal_thymus_morphology1.34765789
46MP0006072_abnormal_retinal_apoptosis1.34597366
47MP0002405_respiratory_system_inflammati1.29302746
48MP0000371_diluted_coat_color1.28807509
49MP0005645_abnormal_hypothalamus_physiol1.27358196
50MP0005174_abnormal_tail_pigmentation1.27330140
51MP0005025_abnormal_response_to1.25121861
52MP0002877_abnormal_melanocyte_morpholog1.23674920
53MP0010307_abnormal_tumor_latency1.22668267
54MP0005464_abnormal_platelet_physiology1.22638853
55MP0008007_abnormal_cellular_replicative1.19232365
56MP0002166_altered_tumor_susceptibility1.19096923
57MP0002452_abnormal_antigen_presenting1.16731304
58MP0008873_increased_physiological_sensi1.16088331
59MP0002102_abnormal_ear_morphology1.14918802
60MP0009379_abnormal_foot_pigmentation1.10096596
61MP0002095_abnormal_skin_pigmentation1.09915097
62MP0002006_tumorigenesis1.08502364
63MP0002722_abnormal_immune_system1.08418066
64MP0008995_early_reproductive_senescence1.08236516
65MP0002429_abnormal_blood_cell1.06845016
66MP0003195_calcinosis1.04507049
67MP0001881_abnormal_mammary_gland1.03573252
68MP0002693_abnormal_pancreas_physiology1.00719762
69MP0000689_abnormal_spleen_morphology1.00605898
70MP0010155_abnormal_intestine_physiology0.99653020
71MP0000569_abnormal_digit_pigmentation0.99472074
72MP0002234_abnormal_pharynx_morphology0.99312936
73MP0003646_muscle_fatigue0.95341903
74MP0002019_abnormal_tumor_incidence0.95053568
75MP0001845_abnormal_inflammatory_respons0.93088888
76MP0006035_abnormal_mitochondrial_morpho0.92826740
77MP0001186_pigmentation_phenotype0.91776055
78MP0003718_maternal_effect0.90785825
79MP0003252_abnormal_bile_duct0.90269308
80MP0002132_abnormal_respiratory_system0.90248609
81MP0002160_abnormal_reproductive_system0.90139034
82MP0003567_abnormal_fetal_cardiomyocyte0.89833270
83MP0001502_abnormal_circadian_rhythm0.89615130
84MP0003448_altered_tumor_morphology0.88500903
85MP0001661_extended_life_span0.87593163
86MP0005360_urolithiasis0.85947640
87MP0000015_abnormal_ear_pigmentation0.83408442
88MP0000613_abnormal_salivary_gland0.82427365
89MP0000627_abnormal_mammary_gland0.81173691
90MP0004742_abnormal_vestibular_system0.80059896
91MP0003045_fibrosis0.77739766
92MP0003878_abnormal_ear_physiology0.76841532
93MP0005377_hearing/vestibular/ear_phenot0.76841532
94MP0001542_abnormal_bone_strength0.75438985
95MP0002090_abnormal_vision0.75197568
96MP0008058_abnormal_DNA_repair0.74211090
97MP0009745_abnormal_behavioral_response0.70353425
98MP0001501_abnormal_sleep_pattern0.69969897
99MP0002075_abnormal_coat/hair_pigmentati0.67397343
100MP0001119_abnormal_female_reproductive0.67243042

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)6.34017355
2T lymphocytopenia (HP:0005403)6.19118282
3Aplastic anemia (HP:0001915)5.91601420
4Autoimmune hemolytic anemia (HP:0001890)5.03188470
5Acute necrotizing encephalopathy (HP:0006965)4.26265344
6Abnormal mitochondria in muscle tissue (HP:0008316)4.07735622
7Abnormality of T cells (HP:0002843)3.79863985
8Mitochondrial inheritance (HP:0001427)3.78958348
9Hypoproteinemia (HP:0003075)3.70065169
10Severe combined immunodeficiency (HP:0004430)3.63814052
11Abnormality of eosinophils (HP:0001879)3.56057714
12Progressive macrocephaly (HP:0004481)3.55801364
13Thyroiditis (HP:0100646)3.40513572
14Oral leukoplakia (HP:0002745)3.33782988
15Acute encephalopathy (HP:0006846)3.33151636
16Renal cortical cysts (HP:0000803)3.30885165
17Increased CSF lactate (HP:0002490)3.11945041
18Chronic diarrhea (HP:0002028)3.11315633
19Eosinophilia (HP:0001880)3.07241504
20Abnormality of the prostate (HP:0008775)3.07003010
21Increased hepatocellular lipid droplets (HP:0006565)3.00893810
22Increased IgM level (HP:0003496)2.99226960
233-Methylglutaconic aciduria (HP:0003535)2.95240324
24Hepatocellular necrosis (HP:0001404)2.87036374
25Autoimmune thrombocytopenia (HP:0001973)2.86828159
26Alveolar cell carcinoma (HP:0006519)2.85213618
27Type I transferrin isoform profile (HP:0003642)2.76270197
28Lipid accumulation in hepatocytes (HP:0006561)2.76250492
29Hepatic necrosis (HP:0002605)2.71721526
30Combined immunodeficiency (HP:0005387)2.69096528
31Ureteral stenosis (HP:0000071)2.67925859
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.63167868
33IgG deficiency (HP:0004315)2.57672967
34Abnormality of the alveolar ridges (HP:0006477)2.52709707
35Reduced antithrombin III activity (HP:0001976)2.52595088
36Leukocytosis (HP:0001974)2.45085467
37Ureteral obstruction (HP:0006000)2.45033681
38Increased intramyocellular lipid droplets (HP:0012240)2.44165101
39Neoplasm of the tracheobronchial system (HP:0100552)2.39928462
40IgM deficiency (HP:0002850)2.39759873
41Renal Fanconi syndrome (HP:0001994)2.37748013
42Cerebral edema (HP:0002181)2.37393269
43Hemoptysis (HP:0002105)2.37388839
44Recurrent bronchitis (HP:0002837)2.36942918
45Pancreatic cysts (HP:0001737)2.36934686
46Abnormality of the renal cortex (HP:0011035)2.36638944
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36096532
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36096532
49Gangrene (HP:0100758)2.36006469
50Optic disc pallor (HP:0000543)2.34856113
51Carpal bone hypoplasia (HP:0001498)2.31672021
52Pancytopenia (HP:0001876)2.29780917
53Granulocytopenia (HP:0001913)2.28543579
54Stomatitis (HP:0010280)2.27376104
55Pulmonary fibrosis (HP:0002206)2.26084489
56Gastrointestinal infarctions (HP:0005244)2.25810447
57Severe visual impairment (HP:0001141)2.22572155
58Methylmalonic acidemia (HP:0002912)2.20952112
59Large eyes (HP:0001090)2.19991691
60Lymphoma (HP:0002665)2.18762884
61Pulmonary infiltrates (HP:0002113)2.18124190
62Vasculitis (HP:0002633)2.13495478
63Colon cancer (HP:0003003)2.12253417
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11889318
65Abnormal protein N-linked glycosylation (HP:0012347)2.11889318
66Abnormal protein glycosylation (HP:0012346)2.11889318
67Abnormal glycosylation (HP:0012345)2.11889318
68Hypoplasia of the thymus (HP:0000778)2.11493937
69Pancreatic islet-cell hyperplasia (HP:0004510)2.11454641
70Joint swelling (HP:0001386)2.11166480
71Abnormality of macrophages (HP:0004311)2.08985150
72Microretrognathia (HP:0000308)2.06293382
73Exertional dyspnea (HP:0002875)2.05899156
74Abnormality of homocysteine metabolism (HP:0010919)2.02092907
75Homocystinuria (HP:0002156)2.02092907
76Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01343983
77Hemiplegia (HP:0002301)2.01179932
78Obstructive lung disease (HP:0006536)2.00492928
79Chronic obstructive pulmonary disease (HP:0006510)2.00492928
80Intestinal atresia (HP:0011100)2.00472319
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.98315819
82Premature graying of hair (HP:0002216)1.98302407
83Conjugated hyperbilirubinemia (HP:0002908)1.97287302
84Increased muscle lipid content (HP:0009058)1.96687918
85Respiratory failure (HP:0002878)1.94203579
86Chest pain (HP:0100749)1.91904955
87Elevated erythrocyte sedimentation rate (HP:0003565)1.91728507
88Pulmonary embolism (HP:0002204)1.91112044
89Abnormality of the astrocytes (HP:0100707)1.90960595
90Astrocytoma (HP:0009592)1.90960595
91Abolished electroretinogram (ERG) (HP:0000550)1.90772997
92Abnormality of methionine metabolism (HP:0010901)1.89514631
93Amyotrophic lateral sclerosis (HP:0007354)1.88875517
94Abnormal albumin level (HP:0012116)1.88281322
95Hypoalbuminemia (HP:0003073)1.88281322
96Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88040715
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83878879
98Amaurosis fugax (HP:0100576)1.81503928
99Abnormality of T cell physiology (HP:0011840)1.81437542
100Lymphopenia (HP:0001888)1.79749482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.78103022
2KDR5.73200343
3BUB14.17083090
4MST43.09296743
5TESK23.03853033
6ITK2.98534895
7MAP3K122.30079007
8STK242.17478275
9VRK22.03194098
10MAP4K12.02328496
11BCKDK2.02214335
12PRKCQ1.90349706
13PIK3CA1.60354319
14TEC1.53839906
15GRK11.53198896
16TESK11.39564070
17CSK1.36248179
18FRK1.25858651
19MATK1.19973452
20ACVR1B1.19971155
21TNK21.17986070
22NUAK11.16686085
23MAPKAPK31.13961616
24AURKA1.13056324
25PASK1.12094131
26AKT31.12003194
27NTRK11.11932205
28BTK1.10473043
29BCR1.10245867
30WNK31.08341783
31ADRBK21.06091567
32WNK41.02723499
33MYLK0.99889011
34MAP2K60.99887627
35DAPK10.96446603
36SYK0.87844432
37LCK0.87822786
38MAP3K100.85818537
39RIPK40.83947666
40VRK10.83780025
41GRK70.83214299
42LIMK10.82891138
43ILK0.81867069
44MAP3K110.81093310
45SRPK10.79095319
46ZAP700.78032254
47PLK40.72465709
48MAP2K70.70742612
49RPS6KA40.70208805
50TRIM280.68097945
51MKNK10.67237285
52MAP4K20.66804702
53PLK20.65560837
54FES0.65479572
55MKNK20.64160111
56FGFR10.63377566
57MAPKAPK50.61857612
58PAK30.60465226
59PINK10.60169376
60OXSR10.58495682
61EIF2AK30.57440164
62TBK10.56037978
63INSRR0.55907644
64LYN0.55616946
65STK100.55565061
66RPS6KA50.55189782
67IKBKB0.54181788
68TIE10.52998837
69TAOK30.52649515
70CDC70.48970523
71CAMK10.48752472
72STK390.47606801
73BMPR1B0.45744238
74MARK30.45532773
75CDK30.40560378
76GRK50.40174807
77ROCK10.39791690
78PRKCH0.37646225
79PRKACA0.37570959
80CAMK2A0.35974703
81CSNK1A10.35103108
82INSR0.34983114
83ATR0.34405826
84MUSK0.34170455
85PHKG20.31657621
86PHKG10.31657621
87PDGFRB0.31347176
88HCK0.31322640
89FYN0.30642224
90PAK40.30385614
91IGF1R0.29256998
92CSNK2A10.26925031
93PRKCA0.26620472
94CSF1R0.25603428
95PAK10.25411668
96IKBKE0.25325517
97OBSCN0.25128490
98GRK60.22680220
99MAPK130.20673900
100DAPK30.20432333

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.75984397
2Primary immunodeficiency_Homo sapiens_hsa053404.23415066
3Protein export_Homo sapiens_hsa030603.56898205
4Graft-versus-host disease_Homo sapiens_hsa053323.19101324
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.18300735
6Oxidative phosphorylation_Homo sapiens_hsa001903.15506919
7Autoimmune thyroid disease_Homo sapiens_hsa053202.53556760
8Parkinsons disease_Homo sapiens_hsa050122.51580052
9T cell receptor signaling pathway_Homo sapiens_hsa046602.38362579
10Antigen processing and presentation_Homo sapiens_hsa046122.38351929
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.31282349
12Hematopoietic cell lineage_Homo sapiens_hsa046402.14926508
13Salmonella infection_Homo sapiens_hsa051322.13079229
14Type I diabetes mellitus_Homo sapiens_hsa049402.09580272
15Allograft rejection_Homo sapiens_hsa053301.97991095
16Rheumatoid arthritis_Homo sapiens_hsa053231.97289208
17Alzheimers disease_Homo sapiens_hsa050101.86557517
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62869236
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60818362
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.59151645
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52523369
22Huntingtons disease_Homo sapiens_hsa050161.50920686
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48574667
24Ribosome_Homo sapiens_hsa030101.47072674
25Homologous recombination_Homo sapiens_hsa034401.46388579
26Retinol metabolism_Homo sapiens_hsa008301.44804244
27Basal transcription factors_Homo sapiens_hsa030221.29311080
28Mismatch repair_Homo sapiens_hsa034301.29197297
29Measles_Homo sapiens_hsa051621.22186143
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15519761
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14289239
32Cardiac muscle contraction_Homo sapiens_hsa042601.10783936
33RNA polymerase_Homo sapiens_hsa030201.10483015
34Shigellosis_Homo sapiens_hsa051311.09108284
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08901740
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04703631
37Sulfur metabolism_Homo sapiens_hsa009201.01923661
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01618417
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99061121
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95655204
41Nucleotide excision repair_Homo sapiens_hsa034200.93576061
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91531485
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.88911050
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86647968
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.84218530
46Fanconi anemia pathway_Homo sapiens_hsa034600.80933862
47Folate biosynthesis_Homo sapiens_hsa007900.78334892
48Vitamin digestion and absorption_Homo sapiens_hsa049770.76300138
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72755067
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71349638
51Non-homologous end-joining_Homo sapiens_hsa034500.69521606
52Peroxisome_Homo sapiens_hsa041460.68975863
53Chemical carcinogenesis_Homo sapiens_hsa052040.66980860
54One carbon pool by folate_Homo sapiens_hsa006700.65482897
55Vitamin B6 metabolism_Homo sapiens_hsa007500.64620585
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64003319
57Chemokine signaling pathway_Homo sapiens_hsa040620.63225659
58DNA replication_Homo sapiens_hsa030300.62369860
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62134175
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53414934
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53116266
62Phototransduction_Homo sapiens_hsa047440.52029486
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51459427
64Viral myocarditis_Homo sapiens_hsa054160.48307792
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48296093
66African trypanosomiasis_Homo sapiens_hsa051430.47979568
67Linoleic acid metabolism_Homo sapiens_hsa005910.46672731
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46113796
69Nitrogen metabolism_Homo sapiens_hsa009100.46111970
70Collecting duct acid secretion_Homo sapiens_hsa049660.45006469
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43107622
72N-Glycan biosynthesis_Homo sapiens_hsa005100.42380914
73Spliceosome_Homo sapiens_hsa030400.41962050
74Mineral absorption_Homo sapiens_hsa049780.40756154
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38821803
76Fatty acid elongation_Homo sapiens_hsa000620.37630793
77p53 signaling pathway_Homo sapiens_hsa041150.36532689
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35890515
79Prion diseases_Homo sapiens_hsa050200.35443752
80Pyrimidine metabolism_Homo sapiens_hsa002400.35319587
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32207923
82Propanoate metabolism_Homo sapiens_hsa006400.29988849
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28634121
84Asthma_Homo sapiens_hsa053100.28459026
85Metabolic pathways_Homo sapiens_hsa011000.26477968
86Caffeine metabolism_Homo sapiens_hsa002320.25888198
87Herpes simplex infection_Homo sapiens_hsa051680.25420236
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23904927
89RNA degradation_Homo sapiens_hsa030180.23867822
90Tryptophan metabolism_Homo sapiens_hsa003800.23560005
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21667282
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20115887
93Ether lipid metabolism_Homo sapiens_hsa005650.20078669
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18909297
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.18345833
96Epstein-Barr virus infection_Homo sapiens_hsa051690.17585700
97Regulation of autophagy_Homo sapiens_hsa041400.17039530
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16232104
99Butanoate metabolism_Homo sapiens_hsa006500.14686485
100Olfactory transduction_Homo sapiens_hsa047400.13985550

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