OR7E7P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to ethanol (GO:0048149)7.78947729
2positive regulation of dendritic spine morphogenesis (GO:0061003)7.46987355
3short-term memory (GO:0007614)6.77480767
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43696005
5regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.18222776
6negative regulation of potassium ion transport (GO:0043267)4.99730300
7regulation of sarcomere organization (GO:0060297)4.85254306
8glial cell proliferation (GO:0014009)4.78892600
9pyrimidine nucleobase catabolic process (GO:0006208)4.63566008
10protein targeting to Golgi (GO:0000042)4.48647162
11establishment of protein localization to Golgi (GO:0072600)4.37250542
12neural tube formation (GO:0001841)4.30461785
13cardiac ventricle formation (GO:0003211)4.29644287
14negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.19681620
15positive regulation of dendritic spine development (GO:0060999)4.09222476
16presynaptic membrane assembly (GO:0097105)4.08868793
17positive regulation of membrane potential (GO:0045838)4.08213650
18retrograde transport, vesicle recycling within Golgi (GO:0000301)4.07304891
19positive regulation of synapse assembly (GO:0051965)4.05023422
20limb bud formation (GO:0060174)4.03872184
21regulation of dendritic spine morphogenesis (GO:0061001)3.93942286
22positive regulation of developmental pigmentation (GO:0048087)3.91962425
23cardiac chamber formation (GO:0003207)3.91200898
24regulation of sensory perception of pain (GO:0051930)3.86669843
25regulation of sensory perception (GO:0051931)3.86669843
26establishment of nucleus localization (GO:0040023)3.86331784
27dendritic spine morphogenesis (GO:0060997)3.85024970
28regulation of pigment cell differentiation (GO:0050932)3.79796423
29postsynaptic membrane organization (GO:0001941)3.79133097
30positive regulation of vasodilation (GO:0045909)3.66676960
31protein localization to synapse (GO:0035418)3.66107080
32nerve growth factor signaling pathway (GO:0038180)3.65181064
33nucleobase catabolic process (GO:0046113)3.64860924
34positive regulation of mitochondrial fission (GO:0090141)3.64208067
35nonmotile primary cilium assembly (GO:0035058)3.61763674
36neurotransmitter-gated ion channel clustering (GO:0072578)3.59094574
37neuron cell-cell adhesion (GO:0007158)3.53084165
38DNA double-strand break processing (GO:0000729)3.51779399
39somite development (GO:0061053)3.50976009
40central nervous system projection neuron axonogenesis (GO:0021952)3.44459591
41presynaptic membrane organization (GO:0097090)3.43536485
42sympathetic nervous system development (GO:0048485)3.39521200
43histone H3-K9 methylation (GO:0051567)3.37992019
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.37848683
45base-excision repair, AP site formation (GO:0006285)3.35375347
46regulation of dendritic spine development (GO:0060998)3.32667646
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.31086657
48DNA damage response, detection of DNA damage (GO:0042769)3.30134687
49regulation of synapse assembly (GO:0051963)3.26913540
50mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.22495344
51positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.22495344
52vocalization behavior (GO:0071625)3.21038508
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19815838
54lymphangiogenesis (GO:0001946)3.18888324
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18160686
56axonal fasciculation (GO:0007413)3.16652490
57regulation of postsynaptic membrane potential (GO:0060078)3.15745656
58central nervous system neuron axonogenesis (GO:0021955)3.15061207
59regulation of Rac GTPase activity (GO:0032314)3.12704770
60neuronal action potential (GO:0019228)3.12361736
61retinal rod cell development (GO:0046548)3.10597324
62fucose catabolic process (GO:0019317)3.07803757
63L-fucose metabolic process (GO:0042354)3.07803757
64L-fucose catabolic process (GO:0042355)3.07803757
65membrane hyperpolarization (GO:0060081)3.07482061
66organelle transport along microtubule (GO:0072384)3.07216775
67positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.06440312
68positive regulation of dendrite morphogenesis (GO:0050775)3.06228299
69positive regulation of amino acid transport (GO:0051957)3.05960483
70protein localization to Golgi apparatus (GO:0034067)3.05404449
71protein polyglutamylation (GO:0018095)3.04151552
72cilium or flagellum-dependent cell motility (GO:0001539)3.02209022
73righting reflex (GO:0060013)3.00740348
74epithelial cilium movement (GO:0003351)2.96712724
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96354385
76regulation of potassium ion transport (GO:0043266)2.90624080
77dentate gyrus development (GO:0021542)2.89935972
78venous blood vessel morphogenesis (GO:0048845)2.87275285
79neuron recognition (GO:0008038)2.83366370
80long-chain fatty acid biosynthetic process (GO:0042759)2.81072582
81regulation of synapse structural plasticity (GO:0051823)2.79067432
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.78399308
83forebrain neuron differentiation (GO:0021879)2.78006815
84retinal ganglion cell axon guidance (GO:0031290)2.74141365
85positive regulation of adenylate cyclase activity (GO:0045762)2.71963027
86kynurenine metabolic process (GO:0070189)2.71811959
87cilium movement (GO:0003341)2.71137413
88positive regulation of microtubule polymerization (GO:0031116)2.70816609
89behavioral defense response (GO:0002209)2.66666214
90behavioral fear response (GO:0001662)2.66666214
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66663176
92synaptic vesicle exocytosis (GO:0016079)2.66287987
93dendritic spine organization (GO:0097061)2.64713249
94synapse assembly (GO:0007416)2.64496390
95glutamate receptor signaling pathway (GO:0007215)2.63803699
96magnesium ion transport (GO:0015693)2.62512961
97positive regulation of reproductive process (GO:2000243)2.58589843
98histone H3-K9 modification (GO:0061647)2.55765741
99fear response (GO:0042596)2.55680530
100regulation of penile erection (GO:0060405)12.8900204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.98904419
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.89009533
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.76476356
4GBX2_23144817_ChIP-Seq_PC3_Human4.45803285
5IGF1R_20145208_ChIP-Seq_DFB_Human4.25250627
6EZH2_22144423_ChIP-Seq_EOC_Human3.48665542
7ZNF274_21170338_ChIP-Seq_K562_Hela3.15174755
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.93403726
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.93362200
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.89446301
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87404596
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.73306510
13TAF15_26573619_Chip-Seq_HEK293_Human2.72196813
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71326842
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.30963730
16FUS_26573619_Chip-Seq_HEK293_Human2.20172045
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05797790
18REST_21632747_ChIP-Seq_MESCs_Mouse2.02300257
19P300_19829295_ChIP-Seq_ESCs_Human1.99022265
20EWS_26573619_Chip-Seq_HEK293_Human1.94323065
21AR_21572438_ChIP-Seq_LNCaP_Human1.86308980
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85749891
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84288074
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83935464
25VDR_22108803_ChIP-Seq_LS180_Human1.79404947
26SMAD4_21799915_ChIP-Seq_A2780_Human1.79273682
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.75448883
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75448883
29RNF2_27304074_Chip-Seq_NSC_Mouse1.72321750
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71763504
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68752604
32CBP_20019798_ChIP-Seq_JUKART_Human1.63467752
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63467752
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62787640
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59948977
36DROSHA_22980978_ChIP-Seq_HELA_Human1.55895871
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55000201
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46081045
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45992078
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45321283
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44417267
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.42712438
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39091925
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39067026
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.37218447
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.34274803
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34028998
48RUNX2_22187159_ChIP-Seq_PCA_Human1.29715266
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28554688
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.28185363
51STAT3_23295773_ChIP-Seq_U87_Human1.27889360
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.27596856
53TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27399233
54TP53_18474530_ChIP-ChIP_U2OS_Human1.27301050
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.26265913
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26152601
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.23818837
58AR_25329375_ChIP-Seq_VCAP_Human1.23449889
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.23236260
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23075946
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22809388
62TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22423292
63ER_23166858_ChIP-Seq_MCF-7_Human1.19554939
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18929488
65RXR_22108803_ChIP-Seq_LS180_Human1.18416494
66TP53_16413492_ChIP-PET_HCT116_Human1.16950239
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16630717
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16418478
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14405061
70TCF4_23295773_ChIP-Seq_U87_Human1.13131699
71IRF1_19129219_ChIP-ChIP_H3396_Human1.11410216
72KDM2B_26808549_Chip-Seq_REH_Human1.10417672
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06133429
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05466340
75AR_19668381_ChIP-Seq_PC3_Human1.04896270
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.01874274
77SOX9_26525672_Chip-Seq_HEART_Mouse1.01044560
78TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99159511
79TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97867450
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.96673398
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95442072
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95281272
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94854813
84NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94461833
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94461833
86JUN_21703547_ChIP-Seq_K562_Human0.93648755
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92876317
88TAL1_26923725_Chip-Seq_HPCs_Mouse0.92645660
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92064933
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.91159034
91WT1_19549856_ChIP-ChIP_CCG9911_Human0.91114847
92AHR_22903824_ChIP-Seq_MCF-7_Human0.89878010
93TBL1_22424771_ChIP-Seq_293T_Human0.89218324
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88656516
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88074449
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85675654
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85613576
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85157279
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84202468
100TCF4_22108803_ChIP-Seq_LS180_Human0.83130954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.06442961
2MP0002822_catalepsy3.62607289
3MP0001529_abnormal_vocalization3.60695076
4MP0004859_abnormal_synaptic_plasticity3.45454515
5MP0000569_abnormal_digit_pigmentation3.16974728
6MP0006276_abnormal_autonomic_nervous3.11247840
7MP0004270_analgesia2.89518378
8MP0005647_abnormal_sex_gland2.88350585
9MP0009046_muscle_twitch2.71342075
10MP0000778_abnormal_nervous_system2.65507667
11MP0005423_abnormal_somatic_nervous2.53016033
12MP0003635_abnormal_synaptic_transmissio2.47624304
13MP0003122_maternal_imprinting2.44371704
14MP0009745_abnormal_behavioral_response2.35452362
15MP0005248_abnormal_Harderian_gland2.26362534
16MP0004742_abnormal_vestibular_system2.23421132
17MP0002102_abnormal_ear_morphology2.21249558
18MP0001984_abnormal_olfaction2.15577125
19MP0004885_abnormal_endolymph2.13473484
20MP0002572_abnormal_emotion/affect_behav2.01950341
21MP0003221_abnormal_cardiomyocyte_apopto1.99803837
22MP0005499_abnormal_olfactory_system1.84411386
23MP0005394_taste/olfaction_phenotype1.84411386
24MP0003787_abnormal_imprinting1.81455570
25MP0004924_abnormal_behavior1.81017930
26MP0005386_behavior/neurological_phenoty1.81017930
27MP0002751_abnormal_autonomic_nervous1.76652318
28MP0002063_abnormal_learning/memory/cond1.72805372
29MP0000955_abnormal_spinal_cord1.72652610
30MP0002735_abnormal_chemical_nociception1.70436532
31MP0002272_abnormal_nervous_system1.61109792
32MP0005253_abnormal_eye_physiology1.59382871
33MP0003121_genomic_imprinting1.56763390
34MP0001485_abnormal_pinna_reflex1.53122811
35MP0004134_abnormal_chest_morphology1.51699075
36MP0002067_abnormal_sensory_capabilities1.51391177
37MP0003329_amyloid_beta_deposits1.50646065
38MP0005187_abnormal_penis_morphology1.49650235
39MP0002064_seizures1.47635422
40MP0008789_abnormal_olfactory_epithelium1.43062632
41MP0001986_abnormal_taste_sensitivity1.43010042
42MP0004811_abnormal_neuron_physiology1.39817841
43MP0006072_abnormal_retinal_apoptosis1.36253743
44MP0005645_abnormal_hypothalamus_physiol1.31431516
45MP0000049_abnormal_middle_ear1.30434802
46MP0001501_abnormal_sleep_pattern1.29978290
47MP0001486_abnormal_startle_reflex1.29197797
48MP0002882_abnormal_neuron_morphology1.28441485
49MP0010368_abnormal_lymphatic_system1.27910182
50MP0002928_abnormal_bile_duct1.26804595
51MP0002184_abnormal_innervation1.26230856
52MP0002557_abnormal_social/conspecific_i1.25811206
53MP0004142_abnormal_muscle_tone1.25235781
54MP0005551_abnormal_eye_electrophysiolog1.24584471
55MP0002734_abnormal_mechanical_nocicepti1.24394872
56MP0001299_abnormal_eye_distance/1.24175971
57MP0001502_abnormal_circadian_rhythm1.20259165
58MP0002282_abnormal_trachea_morphology1.17774367
59MP0001970_abnormal_pain_threshold1.16756684
60MP0002066_abnormal_motor_capabilities/c1.14329728
61MP0002752_abnormal_somatic_nervous1.11767785
62MP0003879_abnormal_hair_cell1.10621508
63MP0002152_abnormal_brain_morphology1.10408927
64MP0005367_renal/urinary_system_phenotyp1.09941506
65MP0000516_abnormal_urinary_system1.09941506
66MP0002177_abnormal_outer_ear1.05151770
67MP0000647_abnormal_sebaceous_gland1.00890335
68MP0002638_abnormal_pupillary_reflex0.98110259
69MP0003567_abnormal_fetal_cardiomyocyte0.98036280
70MP0002234_abnormal_pharynx_morphology0.97562102
71MP0001968_abnormal_touch/_nociception0.97378039
72MP0003943_abnormal_hepatobiliary_system0.94951428
73MP0003861_abnormal_nervous_system0.92070690
74MP0002069_abnormal_eating/drinking_beha0.91812715
75MP0000631_abnormal_neuroendocrine_gland0.91170135
76MP0002233_abnormal_nose_morphology0.89272640
77MP0001963_abnormal_hearing_physiology0.88431108
78MP0003633_abnormal_nervous_system0.87438342
79MP0005083_abnormal_biliary_tract0.87396831
80MP0000604_amyloidosis0.86121222
81MP0005391_vision/eye_phenotype0.85958215
82MP0002095_abnormal_skin_pigmentation0.84828198
83MP0008058_abnormal_DNA_repair0.82282347
84MP0008569_lethality_at_weaning0.82028638
85MP0001340_abnormal_eyelid_morphology0.81567331
86MP0005195_abnormal_posterior_eye0.80556613
87MP0003045_fibrosis0.79079491
88MP0000026_abnormal_inner_ear0.76917854
89MP0000566_synostosis0.76801186
90MP0001905_abnormal_dopamine_level0.75370093
91MP0001943_abnormal_respiration0.73307064
92MP0001545_abnormal_hematopoietic_system0.71442535
93MP0005397_hematopoietic_system_phenotyp0.71442535
94MP0002090_abnormal_vision0.71351114
95MP0003631_nervous_system_phenotype0.70774489
96MP0000751_myopathy0.69820238
97MP0002081_perinatal_lethality0.68065617
98MP0002229_neurodegeneration0.66612707
99MP0004145_abnormal_muscle_electrophysio0.66345093
100MP0001286_abnormal_eye_development0.66280289

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)6.93227025
2Abnormal biliary tract physiology (HP:0012439)5.78154530
3Bile duct proliferation (HP:0001408)5.78154530
4Atonic seizures (HP:0010819)5.44809565
5Cortical dysplasia (HP:0002539)5.42234696
6Absent speech (HP:0001344)5.01286651
7Febrile seizures (HP:0002373)4.71910938
8Abnormality of midbrain morphology (HP:0002418)4.14292344
9Molar tooth sign on MRI (HP:0002419)4.14292344
10Amyotrophic lateral sclerosis (HP:0007354)3.89893275
11Long foot (HP:0001833)3.77915482
12Abolished electroretinogram (ERG) (HP:0000550)3.76965465
13Retinal dysplasia (HP:0007973)3.64783131
14Epileptic encephalopathy (HP:0200134)3.64677984
15Limb dystonia (HP:0002451)3.62927532
16Progressive inability to walk (HP:0002505)3.55268395
17Drooling (HP:0002307)3.29460693
18Bifid tongue (HP:0010297)3.20397489
19Inability to walk (HP:0002540)3.19776445
20Submucous cleft hard palate (HP:0000176)3.16356355
21Excessive salivation (HP:0003781)3.09414120
22Abnormality of the lower motor neuron (HP:0002366)3.02475890
23Absence seizures (HP:0002121)2.94506699
24True hermaphroditism (HP:0010459)2.90962648
25Polyphagia (HP:0002591)2.89210724
26Vacuolated lymphocytes (HP:0001922)2.87331211
27Large earlobe (HP:0009748)2.86275454
28Pancreatic fibrosis (HP:0100732)2.79122375
29Esotropia (HP:0000565)2.70670635
30Widely spaced teeth (HP:0000687)2.67462704
31Impaired vibration sensation in the lower limbs (HP:0002166)2.66320348
32Global brain atrophy (HP:0002283)2.54993827
33Narrow forehead (HP:0000341)2.53536052
34Oculomotor apraxia (HP:0000657)2.51668433
35Pancreatic cysts (HP:0001737)2.48350352
36Dialeptic seizures (HP:0011146)2.48097879
37Cupped ear (HP:0000378)2.47768422
38Nephronophthisis (HP:0000090)2.47283346
39Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.46017349
40Broad-based gait (HP:0002136)2.45914435
41Gonadotropin excess (HP:0000837)2.45032589
42Neoplasm of the adrenal cortex (HP:0100641)2.44352978
43Hemiparesis (HP:0001269)2.43370832
44Urinary urgency (HP:0000012)2.42516408
45Lower limb muscle weakness (HP:0007340)2.41763059
46Decreased muscle mass (HP:0003199)2.39619377
47Intellectual disability, severe (HP:0010864)2.37894688
48Hepatoblastoma (HP:0002884)2.34041708
49Lissencephaly (HP:0001339)2.33485776
50Morphological abnormality of the pyramidal tract (HP:0002062)2.32542858
51Ankle clonus (HP:0011448)2.30572347
52Hammertoe (HP:0001765)2.30537078
53Short philtrum (HP:0000322)2.26533419
54Hypoplasia of the brainstem (HP:0002365)2.24477923
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.24477923
56Pendular nystagmus (HP:0012043)2.23438453
57Supranuclear gaze palsy (HP:0000605)2.19566371
58Abnormality of the columella (HP:0009929)2.18280782
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.15553560
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15553560
61Sensorimotor neuropathy (HP:0007141)2.14427461
62Gait imbalance (HP:0002141)2.08872623
63Epidermoid cyst (HP:0200040)2.08138183
64Difficulty running (HP:0009046)2.05833134
65Abnormality of salivation (HP:0100755)2.05470596
66Focal seizures (HP:0007359)2.03856950
67Curly hair (HP:0002212)2.03670048
68Abnormality of the renal medulla (HP:0100957)2.02315078
69Increased number of teeth (HP:0011069)2.01945494
70Generalized myoclonic seizures (HP:0002123)2.01158868
71Failure to thrive in infancy (HP:0001531)1.94119413
72Autoamputation (HP:0001218)1.93839703
73Poor eye contact (HP:0000817)1.92524382
74Atrophy/Degeneration involving motor neurons (HP:0007373)1.92352651
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91956520
76Colon cancer (HP:0003003)1.90941175
77Thickened helices (HP:0000391)1.89467707
78Exotropia (HP:0000577)1.89410840
79Abnormality of binocular vision (HP:0011514)1.88756896
80Diplopia (HP:0000651)1.88756896
81Nephrogenic diabetes insipidus (HP:0009806)1.88415941
82Dyskinesia (HP:0100660)1.88075665
83Hypoplasia of the corpus callosum (HP:0002079)1.87916245
84Congenital primary aphakia (HP:0007707)1.87304456
85Spastic tetraplegia (HP:0002510)1.87062983
86Medial flaring of the eyebrow (HP:0010747)1.85646407
87Spastic gait (HP:0002064)1.84138827
88Broad foot (HP:0001769)1.84013381
89Open mouth (HP:0000194)1.83851190
90Astrocytoma (HP:0009592)1.83481827
91Abnormality of the astrocytes (HP:0100707)1.83481827
92Generalized tonic-clonic seizures (HP:0002069)1.80653499
93Urinary bladder sphincter dysfunction (HP:0002839)1.80466762
94Abnormal eating behavior (HP:0100738)1.75644594
95Abnormal respiratory motile cilium physiology (HP:0012261)1.74754763
96Specific learning disability (HP:0001328)1.74605781
97Type II lissencephaly (HP:0007260)1.74295392
98Relative macrocephaly (HP:0004482)1.72557617
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71480091
100Distal lower limb amyotrophy (HP:0008944)1.70442552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.64193864
2CASK4.46831872
3MARK14.03054013
4MAP2K73.92520783
5MAP3K63.46822561
6BCR2.86318447
7ACVR1B2.80375550
8FRK2.75426800
9ERBB32.46894102
10CCNB12.46279757
11BMPR1B2.25356646
12EPHA32.25182868
13WNK32.15599059
14ERBB42.06674082
15MAPK131.86690053
16PIM21.79617680
17GRK11.78824251
18CSNK1A1L1.77245532
19CDK191.75554533
20TRIM281.69580576
21EPHB11.67210566
22MAP3K51.55546283
23CAMKK21.53441422
24DYRK21.53245405
25CSNK1G21.52942713
26CSNK1G31.49319029
27DYRK1B1.48267618
28MAP2K41.46064222
29CSNK1G11.45607902
30SIK31.43262089
31SIK21.40661455
32UHMK11.23070942
33DYRK31.18320138
34MARK21.12809914
35ADRBK21.10993850
36CDK61.09667180
37DYRK1A1.06996842
38BRD41.02871451
39MAPK70.99161917
40LATS10.91905630
41TGFBR10.89172847
42FGFR20.87189927
43STK380.82502597
44MAP3K70.82469547
45CAMK40.81823437
46BCKDK0.79197961
47DAPK20.76341435
48FGFR30.74527393
49INSRR0.73576503
50NTRK20.71804691
51RPS6KB20.71156176
52ADRBK10.69710970
53FER0.69257766
54PINK10.67764834
55PAK30.65671383
56CDK50.63022249
57EPHA40.62873567
58PRKCE0.61455983
59CAMK2A0.61098103
60CDC42BPA0.59968108
61CAMKK10.58325487
62PKN20.56321457
63PRKAA10.52736301
64FLT30.52382165
65NTRK30.51206731
66PRKACB0.51090479
67PTK2B0.45566806
68TAOK10.45406521
69STK160.45133461
70RET0.44570798
71STK110.44310665
72MAPK40.43965510
73PLK40.43635716
74PKN10.42675537
75MINK10.40073393
76YES10.39383835
77PRKCG0.38958223
78PRKCZ0.38906956
79IRAK10.37836111
80CSNK1D0.37471938
81STK38L0.36976889
82TNK20.35941685
83PRKG10.33545675
84CAMK10.33498192
85MAPK120.32890121
86ROCK10.32869470
87PAK60.32522498
88GRK70.31460236
89DAPK10.30986617
90DAPK30.28949101
91PRKACA0.27219309
92PRKD20.26918891
93PLK20.25803980
94PRKCB0.25796911
95MAPK80.25776907
96CAMK2B0.24957469
97NEK10.24736173
98MAPK90.24528649
99CDK140.23764943
100RPS6KB10.23037322

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.06038847
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.72839078
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.13799607
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.10989460
5GABAergic synapse_Homo sapiens_hsa047272.84903976
6Taste transduction_Homo sapiens_hsa047422.56675453
7Morphine addiction_Homo sapiens_hsa050322.53564069
8Glutamatergic synapse_Homo sapiens_hsa047242.36020666
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.34843601
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28328121
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19318189
12Circadian entrainment_Homo sapiens_hsa047132.08390684
13Dopaminergic synapse_Homo sapiens_hsa047282.03327504
14Steroid biosynthesis_Homo sapiens_hsa001001.93694814
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72092487
16Cocaine addiction_Homo sapiens_hsa050301.71783490
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69712151
18Phototransduction_Homo sapiens_hsa047441.57182311
19Lysine degradation_Homo sapiens_hsa003101.50572124
20Synaptic vesicle cycle_Homo sapiens_hsa047211.41394721
21Axon guidance_Homo sapiens_hsa043601.34943273
22Serotonergic synapse_Homo sapiens_hsa047261.32452852
23Circadian rhythm_Homo sapiens_hsa047101.31988251
24Cholinergic synapse_Homo sapiens_hsa047251.30921287
25Other glycan degradation_Homo sapiens_hsa005111.27775842
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22472613
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21553369
28Dorso-ventral axis formation_Homo sapiens_hsa043201.18874944
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12778980
30Colorectal cancer_Homo sapiens_hsa052101.12332752
31Amphetamine addiction_Homo sapiens_hsa050311.11545137
32RNA degradation_Homo sapiens_hsa030181.11352324
33mRNA surveillance pathway_Homo sapiens_hsa030151.10766925
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09658178
35Insulin secretion_Homo sapiens_hsa049111.06002571
36Long-term depression_Homo sapiens_hsa047301.04769676
37mTOR signaling pathway_Homo sapiens_hsa041501.01464671
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97188783
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96975471
40Calcium signaling pathway_Homo sapiens_hsa040200.95291358
41Tryptophan metabolism_Homo sapiens_hsa003800.94756624
42Type II diabetes mellitus_Homo sapiens_hsa049300.91395010
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88295962
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84631300
45Regulation of autophagy_Homo sapiens_hsa041400.84426542
46ErbB signaling pathway_Homo sapiens_hsa040120.82787861
47Nitrogen metabolism_Homo sapiens_hsa009100.81867286
48Olfactory transduction_Homo sapiens_hsa047400.81000720
49Gap junction_Homo sapiens_hsa045400.79820596
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76241370
51Ras signaling pathway_Homo sapiens_hsa040140.75441093
52Oocyte meiosis_Homo sapiens_hsa041140.75431046
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72878083
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.72764763
55Rap1 signaling pathway_Homo sapiens_hsa040150.69609016
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69336224
57Butanoate metabolism_Homo sapiens_hsa006500.67155678
58Alcoholism_Homo sapiens_hsa050340.65947206
59Renin secretion_Homo sapiens_hsa049240.63344768
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61630591
61Ether lipid metabolism_Homo sapiens_hsa005650.60597156
62Salivary secretion_Homo sapiens_hsa049700.56497128
63Hedgehog signaling pathway_Homo sapiens_hsa043400.54995238
64Hippo signaling pathway_Homo sapiens_hsa043900.51692918
65Oxytocin signaling pathway_Homo sapiens_hsa049210.50174451
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49322427
67cAMP signaling pathway_Homo sapiens_hsa040240.47276797
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46554672
69Wnt signaling pathway_Homo sapiens_hsa043100.46080355
70Estrogen signaling pathway_Homo sapiens_hsa049150.45300641
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.44836298
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42906789
73GnRH signaling pathway_Homo sapiens_hsa049120.42742577
74Choline metabolism in cancer_Homo sapiens_hsa052310.41115710
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.39811206
76Propanoate metabolism_Homo sapiens_hsa006400.38744698
77Glioma_Homo sapiens_hsa052140.38312283
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.37905775
79Gastric acid secretion_Homo sapiens_hsa049710.37626701
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36165930
81Tight junction_Homo sapiens_hsa045300.36108050
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36098118
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.36078340
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36053076
85MicroRNAs in cancer_Homo sapiens_hsa052060.35211379
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34628603
87Endocytosis_Homo sapiens_hsa041440.34157000
88Endometrial cancer_Homo sapiens_hsa052130.32816239
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31435808
90Vitamin B6 metabolism_Homo sapiens_hsa007500.31379955
91MAPK signaling pathway_Homo sapiens_hsa040100.31273588
92Shigellosis_Homo sapiens_hsa051310.29561129
93Collecting duct acid secretion_Homo sapiens_hsa049660.28575513
94Histidine metabolism_Homo sapiens_hsa003400.28226926
95Chemical carcinogenesis_Homo sapiens_hsa052040.27364176
96Base excision repair_Homo sapiens_hsa034100.26671427
97Sphingolipid metabolism_Homo sapiens_hsa006000.26374108
98Fatty acid elongation_Homo sapiens_hsa000620.25964198
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25632559
100Melanoma_Homo sapiens_hsa052180.24000528

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