ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.33977855
2	response to pheromone (GO:0019236)	5.45237418
3	L-fucose catabolic process (GO:0042355)	4.26735600
4	fucose catabolic process (GO:0019317)	4.26735600
5	L-fucose metabolic process (GO:0042354)	4.26735600
6	serotonin metabolic process (GO:0042428)	3.77007605
7	sulfation (GO:0051923)	3.66441388
8	indolalkylamine metabolic process (GO:0006586)	3.66199810
9	kynurenine metabolic process (GO:0070189)	3.65070776
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.62431248
11	indole-containing compound catabolic process (GO:0042436)	3.61914355
12	indolalkylamine catabolic process (GO:0046218)	3.61914355
13	tryptophan catabolic process (GO:0006569)	3.61914355
14	primary amino compound metabolic process (GO:1901160)	3.57127378
15	platelet dense granule organization (GO:0060155)	3.41331038
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.40085883
17	indole-containing compound metabolic process (GO:0042430)	3.39664271
18	neuronal action potential (GO:0019228)	3.39202298
19	cellular ketone body metabolic process (GO:0046950)	3.32279369
20	nephron tubule morphogenesis (GO:0072078)	3.29519524
21	nephron epithelium morphogenesis (GO:0072088)	3.29519524
22	cilium or flagellum-dependent cell motility (GO:0001539)	3.27066091
23	detection of light stimulus involved in visual perception (GO:0050908)	3.20184525
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.20184525
25	negative regulation of telomere maintenance (GO:0032205)	3.20043263
26	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.17027074
27	gamma-aminobutyric acid transport (GO:0015812)	3.16755382
28	epithelial cilium movement (GO:0003351)	3.16583138
29	neural tube formation (GO:0001841)	3.11554250
30	tryptophan metabolic process (GO:0006568)	3.04627285
31	DNA deamination (GO:0045006)	3.03895406
32	nonmotile primary cilium assembly (GO:0035058)	3.00230092
33	regulation of hippo signaling (GO:0035330)	2.99771990
34	reflex (GO:0060004)	2.96527040
35	piRNA metabolic process (GO:0034587)	2.96153370
36	regulation of gene silencing by miRNA (GO:0060964)	2.95005233
37	regulation of gene silencing by RNA (GO:0060966)	2.95005233
38	regulation of posttranscriptional gene silencing (GO:0060147)	2.95005233
39	cilium movement (GO:0003341)	2.92361056
40	ketone body metabolic process (GO:1902224)	2.91697135
41	regulation of action potential (GO:0098900)	2.89490790
42	behavioral response to ethanol (GO:0048149)	2.84591146
43	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.82715836
44	cornea development in camera-type eye (GO:0061303)	2.79154405
45	rhodopsin mediated signaling pathway (GO:0016056)	2.78693185
46	synaptic transmission, cholinergic (GO:0007271)	2.78481382
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.77418418
48	NADH dehydrogenase complex assembly (GO:0010257)	2.77418418
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.77418418
50	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.75777431
51	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.75525030
52	water-soluble vitamin biosynthetic process (GO:0042364)	2.75513267
53	protein complex biogenesis (GO:0070271)	2.75157320
54	adaptation of signaling pathway (GO:0023058)	2.73237195
55	ubiquinone biosynthetic process (GO:0006744)	2.72202837
56	dopamine transport (GO:0015872)	2.70931995
57	kidney morphogenesis (GO:0060993)	2.70098547
58	transmission of nerve impulse (GO:0019226)	2.70098320
59	regulation of mesoderm development (GO:2000380)	2.69156573
60	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.68654027
61	cAMP catabolic process (GO:0006198)	2.64650465
62	cilium morphogenesis (GO:0060271)	2.63781869
63	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.63253343
64	membrane depolarization during action potential (GO:0086010)	2.62171924
65	regulation of neurotransmitter uptake (GO:0051580)	2.61825999
66	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.59913668
67	positive regulation of action potential (GO:0045760)	2.58849699
68	rRNA catabolic process (GO:0016075)	2.58837593
69	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.58149408
70	regulation of cilium movement (GO:0003352)	2.57442209
71	axoneme assembly (GO:0035082)	2.56011161
72	protein import into peroxisome matrix (GO:0016558)	2.55868184
73	ubiquinone metabolic process (GO:0006743)	2.55563170
74	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.54716071
75	postsynaptic membrane organization (GO:0001941)	2.53921866
76	glycerophospholipid catabolic process (GO:0046475)	2.53531050
77	peristalsis (GO:0030432)	2.50839433
78	negative regulation of mast cell activation (GO:0033004)	2.50551651
79	alanine transport (GO:0032328)	2.50271401
80	cilium organization (GO:0044782)	2.49878209
81	retinal cone cell development (GO:0046549)	2.49452890
82	cellular biogenic amine catabolic process (GO:0042402)	2.48047501
83	amine catabolic process (GO:0009310)	2.48047501
84	NAD biosynthetic process (GO:0009435)	2.47939048
85	mitochondrial respiratory chain complex assembly (GO:0033108)	2.47469659
86	protein K11-linked deubiquitination (GO:0035871)	2.46890633
87	somite development (GO:0061053)	2.46498668
88	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.45967324
89	regulation of translation, ncRNA-mediated (GO:0045974)	2.45967324
90	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.45967324
91	renal tubule morphogenesis (GO:0061333)	2.45842053
92	spinal cord motor neuron differentiation (GO:0021522)	2.45277410
93	central nervous system myelination (GO:0022010)	2.43306094
94	axon ensheathment in central nervous system (GO:0032291)	2.43306094
95	cilium assembly (GO:0042384)	2.42310665
96	photoreceptor cell maintenance (GO:0045494)	2.42220719
97	respiratory chain complex IV assembly (GO:0008535)	2.41925914
98	positive regulation of fatty acid transport (GO:2000193)	2.41674004
99	DNA methylation involved in gamete generation (GO:0043046)	2.41648353
100	cellular response to ATP (GO:0071318)	2.41355208

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.25226729
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.82703228
3	VDR_22108803_ChIP-Seq_LS180_Human	3.43497338
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.16902647
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.02046385
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56013354
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.48868589
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45302323
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21160386
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15547287
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14893323
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07049565
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01341698
14	P300_19829295_ChIP-Seq_ESCs_Human	1.92119312
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89776372
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.89176315
17	EWS_26573619_Chip-Seq_HEK293_Human	1.85084772
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.82708354
19	FUS_26573619_Chip-Seq_HEK293_Human	1.81452404
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72548436
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65560314
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62862428
23	AR_21572438_ChIP-Seq_LNCaP_Human	1.62842535
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62418909
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62284390
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.61979132
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61067888
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55675974
29	STAT3_23295773_ChIP-Seq_U87_Human	1.53118160
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.52489138
31	AR_25329375_ChIP-Seq_VCAP_Human	1.51235922
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.49456124
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.48662454
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.48273108
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43368226
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43368226
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43239099
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43137733
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42791266
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42710738
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42377920
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40240055
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.39903064
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35766061
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35695965
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35695965
47	TCF4_23295773_ChIP-Seq_U87_Human	1.34294771
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34050151
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32735290
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30897674
51	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.30722287
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30471722
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30352066
54	DROSHA_22980978_ChIP-Seq_HELA_Human	1.29988110
55	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29880246
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29556168
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.29556168
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29509240
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29434861
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.29184597
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29042498
62	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.28877186
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28499411
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27946354
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25975563
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25975563
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23097322
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22430546
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.19337031
70	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18786682
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16946222
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16375988
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15538071
74	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14821092
75	MYC_18940864_ChIP-ChIP_HL60_Human	1.14665427
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14254110
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13655667
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13326478
79	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12042976
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10653604
81	AR_20517297_ChIP-Seq_VCAP_Human	1.10640913
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10386252
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09062180
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07206433
85	NCOR_22424771_ChIP-Seq_293T_Human	1.07176044
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06754750
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06507493
88	TP53_16413492_ChIP-PET_HCT116_Human	1.06261881
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06134218
90	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05941793
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05839637
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05786253
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05553821
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04485055
95	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03571778
96	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01550237
97	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01026943
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00149363
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97003751
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96387196

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.37767450
2	MP0002653_abnormal_ependyma_morphology	2.77641613
3	MP0000569_abnormal_digit_pigmentation	2.74601159
4	MP0008877_abnormal_DNA_methylation	2.72368160
5	MP0003195_calcinosis	2.69799880
6	MP0005551_abnormal_eye_electrophysiolog	2.50915600
7	MP0001968_abnormal_touch/_nociception	2.39223090
8	MP0005084_abnormal_gallbladder_morpholo	2.37775930
9	MP0009046_muscle_twitch	2.23858299
10	MP0009745_abnormal_behavioral_response	2.21624768
11	MP0004885_abnormal_endolymph	2.14441488
12	MP0004142_abnormal_muscle_tone	2.10048333
13	MP0001485_abnormal_pinna_reflex	2.09361119
14	MP0002736_abnormal_nociception_after	2.06550462
15	MP0002102_abnormal_ear_morphology	2.04760925
16	MP0006292_abnormal_olfactory_placode	1.99031258
17	MP0004147_increased_porphyrin_level	1.97196248
18	MP0008872_abnormal_physiological_respon	1.95330445
19	MP0001501_abnormal_sleep_pattern	1.88946240
20	MP0006072_abnormal_retinal_apoptosis	1.88164722
21	MP0004133_heterotaxia	1.88126884
22	MP0002638_abnormal_pupillary_reflex	1.86503104
23	MP0005645_abnormal_hypothalamus_physiol	1.85702725
24	MP0002272_abnormal_nervous_system	1.85120439
25	MP0005646_abnormal_pituitary_gland	1.78729621
26	MP0002735_abnormal_chemical_nociception	1.70195037
27	MP0008875_abnormal_xenobiotic_pharmacok	1.69917317
28	MP0002572_abnormal_emotion/affect_behav	1.65801434
29	MP0002277_abnormal_respiratory_mucosa	1.64686327
30	MP0003646_muscle_fatigue	1.63641257
31	MP0002064_seizures	1.63327124
32	MP0003787_abnormal_imprinting	1.62367513
33	MP0006276_abnormal_autonomic_nervous	1.61614867
34	MP0003880_abnormal_central_pattern	1.61401011
35	MP0002837_dystrophic_cardiac_calcinosis	1.60608169
36	MP0001486_abnormal_startle_reflex	1.58795363
37	MP0004043_abnormal_pH_regulation	1.57214589
38	MP0002876_abnormal_thyroid_physiology	1.56998461
39	MP0004130_abnormal_muscle_cell	1.56603510
40	MP0002733_abnormal_thermal_nociception	1.55183766
41	MP0004742_abnormal_vestibular_system	1.53017880
42	MP0005253_abnormal_eye_physiology	1.52833846
43	MP0000631_abnormal_neuroendocrine_gland	1.52022156
44	MP0001529_abnormal_vocalization	1.47498922
45	MP0002938_white_spotting	1.47117252
46	MP0001970_abnormal_pain_threshold	1.45146764
47	MP0003011_delayed_dark_adaptation	1.44645636
48	MP0000427_abnormal_hair_cycle	1.42585736
49	MP0002067_abnormal_sensory_capabilities	1.37120543
50	MP0001986_abnormal_taste_sensitivity	1.37002287
51	MP0002928_abnormal_bile_duct	1.36908290
52	MP0003635_abnormal_synaptic_transmissio	1.36240264
53	MP0002063_abnormal_learning/memory/cond	1.29925816
54	MP0002557_abnormal_social/conspecific_i	1.26729756
55	MP0003890_abnormal_embryonic-extraembry	1.24353873
56	MP0004145_abnormal_muscle_electrophysio	1.19856535
57	MP0003283_abnormal_digestive_organ	1.18339787
58	MP0000383_abnormal_hair_follicle	1.18179217
59	MP0001905_abnormal_dopamine_level	1.16579379
60	MP0005389_reproductive_system_phenotype	1.16485243
61	MP0005174_abnormal_tail_pigmentation	1.16302794
62	MP0002160_abnormal_reproductive_system	1.15180331
63	MP0000230_abnormal_systemic_arterial	1.13608857
64	MP0008961_abnormal_basal_metabolism	1.10189488
65	MP0002734_abnormal_mechanical_nocicepti	1.09830815
66	MP0005167_abnormal_blood-brain_barrier	1.09070239
67	MP0005195_abnormal_posterior_eye	1.08307213
68	MP0000372_irregular_coat_pigmentation	1.08067129
69	MP0010386_abnormal_urinary_bladder	1.06832358
70	MP0004924_abnormal_behavior	1.05679947
71	MP0005386_behavior/neurological_phenoty	1.05679947
72	MP0000026_abnormal_inner_ear	1.05337370
73	MP0001919_abnormal_reproductive_system	1.01784826
74	MP0005377_hearing/vestibular/ear_phenot	0.99653842
75	MP0003878_abnormal_ear_physiology	0.99653842
76	MP0005448_abnormal_energy_balance	0.97911300
77	MP0001440_abnormal_grooming_behavior	0.96557767
78	MP0001963_abnormal_hearing_physiology	0.95842132
79	MP0003119_abnormal_digestive_system	0.91331103
80	MP0005410_abnormal_fertilization	0.91216786
81	MP0002752_abnormal_somatic_nervous	0.90352513
82	MP0005085_abnormal_gallbladder_physiolo	0.89815959
83	MP0001984_abnormal_olfaction	0.89149557
84	MP0002909_abnormal_adrenal_gland	0.87895943
85	MP0005423_abnormal_somatic_nervous	0.87443831
86	MP0002751_abnormal_autonomic_nervous	0.87021404
87	MP0003638_abnormal_response/metabolism_	0.86583839
88	MP0003252_abnormal_bile_duct	0.85293978
89	MP0003137_abnormal_impulse_conducting	0.84926182
90	MP0002693_abnormal_pancreas_physiology	0.81675936
91	MP0000778_abnormal_nervous_system	0.78974495
92	MP0002229_neurodegeneration	0.78439384
93	MP0000647_abnormal_sebaceous_gland	0.77096377
94	MP0003122_maternal_imprinting	0.77042677
95	MP0003121_genomic_imprinting	0.77008241
96	MP0005379_endocrine/exocrine_gland_phen	0.76555555
97	MP0010329_abnormal_lipoprotein_level	0.76213687
98	MP0000470_abnormal_stomach_morphology	0.75865940
99	MP0003698_abnormal_male_reproductive	0.75419406
100	MP0002184_abnormal_innervation	0.75272146

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.45898180
2	Abnormality of midbrain morphology (HP:0002418)	4.23277559
3	Molar tooth sign on MRI (HP:0002419)	4.23277559
4	Pancreatic cysts (HP:0001737)	4.18899412
5	True hermaphroditism (HP:0010459)	3.79410535
6	Nephronophthisis (HP:0000090)	3.78797261
7	Pancreatic fibrosis (HP:0100732)	3.77301055
8	Type II lissencephaly (HP:0007260)	3.47716405
9	Hyperventilation (HP:0002883)	3.31906104
10	Large for gestational age (HP:0001520)	3.30729542
11	Congenital, generalized hypertrichosis (HP:0004540)	3.28708941
12	Abnormality of the renal medulla (HP:0100957)	3.21849995
13	Abnormality of alanine metabolism (HP:0010916)	3.08224407
14	Hyperalaninemia (HP:0003348)	3.08224407
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.08224407
16	Abnormality of the renal cortex (HP:0011035)	3.05660573
17	Attenuation of retinal blood vessels (HP:0007843)	3.02179246
18	Medial flaring of the eyebrow (HP:0010747)	2.88580059
19	Progressive cerebellar ataxia (HP:0002073)	2.79467317
20	Absent/shortened dynein arms (HP:0200106)	2.71222683
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.71222683
22	Inability to walk (HP:0002540)	2.69127623
23	Furrowed tongue (HP:0000221)	2.68555832
24	Concave nail (HP:0001598)	2.68516423
25	Birth length less than 3rd percentile (HP:0003561)	2.65610999
26	Tubular atrophy (HP:0000092)	2.64853647
27	Chronic hepatic failure (HP:0100626)	2.59235355
28	Cystic liver disease (HP:0006706)	2.53415751
29	Abolished electroretinogram (ERG) (HP:0000550)	2.53253073
30	Sclerocornea (HP:0000647)	2.46996609
31	Polydipsia (HP:0001959)	2.46433378
32	Abnormal drinking behavior (HP:0030082)	2.46433378
33	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.44182023
34	Optic nerve hypoplasia (HP:0000609)	2.41635561
35	Polyuria (HP:0000103)	2.40659733
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.40116892
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.40116892
38	Genetic anticipation (HP:0003743)	2.39854642
39	Decreased central vision (HP:0007663)	2.35735029
40	Progressive inability to walk (HP:0002505)	2.34736725
41	Gait imbalance (HP:0002141)	2.33474910
42	Pendular nystagmus (HP:0012043)	2.33017039
43	Lissencephaly (HP:0001339)	2.26220681
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.25272008
45	Increased corneal curvature (HP:0100692)	2.23640370
46	Keratoconus (HP:0000563)	2.23640370
47	Congenital primary aphakia (HP:0007707)	2.22820346
48	Abnormal ciliary motility (HP:0012262)	2.22724581
49	Protruding tongue (HP:0010808)	2.22464506
50	Gaze-evoked nystagmus (HP:0000640)	2.19168229
51	Patellar aplasia (HP:0006443)	2.18981139
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.12656061
53	Hemiparesis (HP:0001269)	2.11884377
54	Aplasia/Hypoplasia of the patella (HP:0006498)	2.10643099
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10455830
56	Cerebellar dysplasia (HP:0007033)	2.10183186
57	Partial agenesis of the corpus callosum (HP:0001338)	2.08335698
58	Abnormality of the pons (HP:0007361)	2.07012995
59	Severe muscular hypotonia (HP:0006829)	2.04561909
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.04550755
61	Febrile seizures (HP:0002373)	2.02929430
62	Decreased circulating renin level (HP:0003351)	2.01968073
63	Nephrogenic diabetes insipidus (HP:0009806)	2.01482871
64	Renal cortical cysts (HP:0000803)	1.96453014
65	Anencephaly (HP:0002323)	1.96224773
66	Anophthalmia (HP:0000528)	1.95455533
67	Male pseudohermaphroditism (HP:0000037)	1.95117878
68	Abnormal respiratory motile cilium physiology (HP:0012261)	1.95113441
69	Broad-based gait (HP:0002136)	1.95012492
70	Clumsiness (HP:0002312)	1.93553281
71	Septo-optic dysplasia (HP:0100842)	1.91882701
72	3-Methylglutaconic aciduria (HP:0003535)	1.90877634
73	Abnormal urine output (HP:0012590)	1.90835352
74	Hypoplasia of the pons (HP:0012110)	1.90560104
75	Congenital hepatic fibrosis (HP:0002612)	1.89776499
76	Focal motor seizures (HP:0011153)	1.88265310
77	Chorioretinal atrophy (HP:0000533)	1.87729127
78	Optic disc pallor (HP:0000543)	1.87398385
79	Genital tract atresia (HP:0001827)	1.87242945
80	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85014032
81	Vaginal atresia (HP:0000148)	1.84584333
82	Limb dystonia (HP:0002451)	1.84020243
83	Abnormal biliary tract physiology (HP:0012439)	1.82340308
84	Bile duct proliferation (HP:0001408)	1.82340308
85	Hypomagnesemia (HP:0002917)	1.82336565
86	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.82224056
87	Mesangial abnormality (HP:0001966)	1.80594274
88	Amelogenesis imperfecta (HP:0000705)	1.80566089
89	Prominent supraorbital ridges (HP:0000336)	1.80441317
90	Neuroendocrine neoplasm (HP:0100634)	1.78949286
91	Tachypnea (HP:0002789)	1.76519697
92	Pheochromocytoma (HP:0002666)	1.74824838
93	Acute necrotizing encephalopathy (HP:0006965)	1.74612035
94	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.74450836
95	Hypoplasia of the fovea (HP:0007750)	1.74450836
96	Abnormality of renal excretion (HP:0011036)	1.74450454
97	Congenital sensorineural hearing impairment (HP:0008527)	1.73401607
98	Mitochondrial inheritance (HP:0001427)	1.72803749
99	Retinal dysplasia (HP:0007973)	1.72479278
100	Pachygyria (HP:0001302)	1.72399961

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.77173899
2	BMPR1B	4.08854849
3	ACVR1B	3.88311356
4	ADRBK2	3.48245425
5	WNK3	2.67884940
6	ZAK	2.66304129
7	GRK1	2.56471471
8	WNK4	2.43265663
9	PNCK	2.39115605
10	PINK1	2.29430235
11	TLK1	2.12396458
12	INSRR	2.09980631
13	CASK	2.02807090
14	MAP4K2	1.94786323
15	NTRK2	1.92557932
16	CAMKK2	1.92055808
17	TAOK3	1.88785571
18	MAPK13	1.77597541
19	TGFBR1	1.75280033
20	MAP3K4	1.74572180
21	DAPK2	1.61041655
22	MAPK15	1.49269960
23	TNIK	1.48651054
24	ADRBK1	1.45113740
25	OXSR1	1.37284941
26	NUAK1	1.32561090
27	SIK2	1.21045031
28	DYRK2	1.16213098
29	PRKCG	1.14578641
30	MAP2K7	1.08821954
31	STK39	1.08123860
32	WEE1	1.07643002
33	MKNK2	1.06511744
34	PTK2B	1.04503511
35	CAMK1D	0.98460251
36	TXK	0.96378926
37	PAK3	0.95659914
38	NTRK3	0.95385133
39	NEK2	0.95045886
40	TIE1	0.83705883
41	PRKCE	0.82631904
42	MARK1	0.82175847
43	CAMKK1	0.80577102
44	BCKDK	0.79963208
45	CAMK1G	0.77497719
46	NME1	0.76928457
47	PIK3CA	0.72227596
48	IRAK4	0.70506815
49	CAMK2A	0.70097196
50	PKN1	0.69971824
51	VRK1	0.68903384
52	STK3	0.68030091
53	MUSK	0.67215519
54	MAPKAPK3	0.66018899
55	PRKCQ	0.65906659
56	MAP2K6	0.65741361
57	TEC	0.63380228
58	RPS6KA5	0.62963675
59	STK38L	0.61708213
60	CAMK1	0.60672727
61	CSNK1G2	0.58681176
62	MAP2K1	0.58173286
63	MAPKAPK5	0.56925769
64	IKBKB	0.53214959
65	PHKG1	0.51004960
66	PHKG2	0.51004960
67	BRSK2	0.50319693
68	RPS6KA6	0.48589063
69	STK11	0.48492627
70	MAP2K2	0.47611333
71	PRKACA	0.47079071
72	ITK	0.47040529
73	MAP2K4	0.45565990
74	PLK2	0.44779103
75	SYK	0.44575245
76	CHUK	0.42818350
77	KIT	0.40740702
78	CDK3	0.39669395
79	CSNK1G1	0.39321491
80	GRK7	0.38530945
81	TYRO3	0.37817268
82	PRKCA	0.37804461
83	OBSCN	0.37209133
84	TRPM7	0.36502583
85	SGK2	0.36392590
86	CAMK4	0.36049640
87	MATK	0.35909224
88	CSNK1A1	0.35895467
89	ERBB2	0.35407907
90	IRAK1	0.34613093
91	PIK3CG	0.33974977
92	MST4	0.33141404
93	CSNK1G3	0.32976502
94	PRKG1	0.32630153
95	PRKCZ	0.32129741
96	SGK223	0.29097092
97	SGK494	0.29097092
98	STK16	0.28968920
99	MKNK1	0.28570585
100	CSNK1D	0.28041530

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.34210043
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.22028458
3	Phototransduction_Homo sapiens_hsa04744	2.89998486
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.68922170
5	Nicotine addiction_Homo sapiens_hsa05033	2.68266170
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.24991476
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.22289706
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.19983328
9	Butanoate metabolism_Homo sapiens_hsa00650	2.18111327
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.12999566
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.10351301
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.03695666
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.99167110
14	Olfactory transduction_Homo sapiens_hsa04740	1.85134140
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83059906
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.80593558
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.76919008
18	Morphine addiction_Homo sapiens_hsa05032	1.73425859
19	Parkinsons disease_Homo sapiens_hsa05012	1.66124041
20	Taste transduction_Homo sapiens_hsa04742	1.65400888
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62091337
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45427872
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44464087
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.43153757
25	GABAergic synapse_Homo sapiens_hsa04727	1.39126367
26	Glutamatergic synapse_Homo sapiens_hsa04724	1.39036088
27	Circadian entrainment_Homo sapiens_hsa04713	1.39030654
28	Serotonergic synapse_Homo sapiens_hsa04726	1.36610930
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35012877
30	Protein export_Homo sapiens_hsa03060	1.31316949
31	Homologous recombination_Homo sapiens_hsa03440	1.27762554
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.26085803
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25654807
34	Caffeine metabolism_Homo sapiens_hsa00232	1.25551838
35	Insulin secretion_Homo sapiens_hsa04911	1.25379300
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18794686
37	ABC transporters_Homo sapiens_hsa02010	1.18218759
38	Alzheimers disease_Homo sapiens_hsa05010	1.11313599
39	RNA polymerase_Homo sapiens_hsa03020	1.10635797
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10026752
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09185240
42	Huntingtons disease_Homo sapiens_hsa05016	1.09070104
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.06422813
44	Cocaine addiction_Homo sapiens_hsa05030	1.04645387
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00639430
46	Basal transcription factors_Homo sapiens_hsa03022	1.00490944
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.99565852
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99332284
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99160108
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.98395421
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95071426
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92506826
53	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92438872
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91175687
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90218574
56	Peroxisome_Homo sapiens_hsa04146	0.89265528
57	Salivary secretion_Homo sapiens_hsa04970	0.88393963
58	Asthma_Homo sapiens_hsa05310	0.83392595
59	Retinol metabolism_Homo sapiens_hsa00830	0.83332094
60	Amphetamine addiction_Homo sapiens_hsa05031	0.82851589
61	Long-term depression_Homo sapiens_hsa04730	0.80143158
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79446151
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76991383
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.76782231
65	RNA degradation_Homo sapiens_hsa03018	0.76692272
66	Sulfur relay system_Homo sapiens_hsa04122	0.75910854
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75103855
68	Cholinergic synapse_Homo sapiens_hsa04725	0.71756219
69	Gastric acid secretion_Homo sapiens_hsa04971	0.71177188
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66399520
71	One carbon pool by folate_Homo sapiens_hsa00670	0.66001949
72	Histidine metabolism_Homo sapiens_hsa00340	0.65354513
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59648425
74	Sulfur metabolism_Homo sapiens_hsa00920	0.58813787
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.58063762
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55653248
77	cAMP signaling pathway_Homo sapiens_hsa04024	0.52459838
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51612088
79	Propanoate metabolism_Homo sapiens_hsa00640	0.50548828
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50168081
81	Pancreatic secretion_Homo sapiens_hsa04972	0.48688360
82	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.47822582
83	Purine metabolism_Homo sapiens_hsa00230	0.47490056
84	Ribosome_Homo sapiens_hsa03010	0.46917785
85	Bile secretion_Homo sapiens_hsa04976	0.45884640
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43280247
87	Regulation of autophagy_Homo sapiens_hsa04140	0.41802764
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41375801
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41305905
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39842534
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39805496
92	Metabolic pathways_Homo sapiens_hsa01100	0.39699089
93	Mineral absorption_Homo sapiens_hsa04978	0.38161601
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37665354
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.36420554
96	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34355653
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33470967
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.32073365
99	Renin secretion_Homo sapiens_hsa04924	0.31420950
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31262844

OR7E94P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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