OR8B1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.92714717
2sensory perception of smell (GO:0007608)8.24141355
3detection of chemical stimulus involved in sensory perception of smell (GO:0050911)7.64935613
4tachykinin receptor signaling pathway (GO:0007217)7.21921721
5cellular ketone body metabolic process (GO:0046950)5.78802427
6regulation of glycogen (starch) synthase activity (GO:2000465)5.59046202
7sensory perception of chemical stimulus (GO:0007606)5.53519006
8phosphorelay signal transduction system (GO:0000160)5.30071464
9ketone body metabolic process (GO:1902224)5.12283721
10detection of chemical stimulus involved in sensory perception (GO:0050907)4.97397224
11genetic imprinting (GO:0071514)4.82579640
12intermediate filament organization (GO:0045109)4.78947320
13positive regulation of action potential (GO:0045760)4.72940573
14histone H3-K9 methylation (GO:0051567)4.72175494
15uterus development (GO:0060065)4.69519964
16postsynaptic membrane organization (GO:0001941)4.30351061
17axon development (GO:0061564)4.28285131
18rRNA methylation (GO:0031167)4.23079105
19regulation of memory T cell differentiation (GO:0043380)4.14903134
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.12362669
21positive regulation of cell cycle checkpoint (GO:1901978)3.97800723
22collecting duct development (GO:0072044)3.94312115
23histone H3-K9 modification (GO:0061647)3.88679454
24spinal cord association neuron differentiation (GO:0021527)3.86673202
25regulation of gene expression by genetic imprinting (GO:0006349)3.78939681
26mitochondrion distribution (GO:0048311)3.75865834
27detection of chemical stimulus (GO:0009593)3.72506968
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69105065
29erythrocyte maturation (GO:0043249)3.68054711
30protein neddylation (GO:0045116)3.66670225
31negative regulation of heart rate (GO:0010459)3.64127111
32translational termination (GO:0006415)3.63263505
33viral transcription (GO:0019083)3.62914259
34heterochromatin organization (GO:0070828)3.60667476
35regulation of mitotic spindle checkpoint (GO:1903504)3.58113280
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58113280
37ribosomal small subunit assembly (GO:0000028)3.56683259
38snRNA transcription (GO:0009301)3.56391962
39forebrain neuron differentiation (GO:0021879)3.52521026
40interferon-gamma production (GO:0032609)3.52199368
41cell junction maintenance (GO:0034331)3.51156968
42axon regeneration (GO:0031103)3.48198278
43negative regulation of neurotransmitter secretion (GO:0046929)3.42891104
44regulation of DNA methylation (GO:0044030)3.41209236
45establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.38652772
46mitochondrion transport along microtubule (GO:0047497)3.38652772
47peptidyl-lysine trimethylation (GO:0018023)3.35104163
48negative regulation of activin receptor signaling pathway (GO:0032926)3.34473197
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.32460230
50rRNA modification (GO:0000154)3.31279287
51positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.28406537
52ADP metabolic process (GO:0046031)3.27767906
53respiratory tube development (GO:0030323)3.25296975
54synapsis (GO:0007129)3.22938742
55regulation of microtubule-based movement (GO:0060632)3.17710233
56regulation of collateral sprouting (GO:0048670)3.12971899
57behavioral response to nicotine (GO:0035095)3.12808932
58negative regulation of glycogen biosynthetic process (GO:0045719)3.11129692
59mitochondrion localization (GO:0051646)3.10639268
60response to lipoprotein particle (GO:0055094)3.09299863
61cerebellar Purkinje cell differentiation (GO:0021702)3.07673657
62proteasome assembly (GO:0043248)3.06779573
63poly(A)+ mRNA export from nucleus (GO:0016973)3.05314681
64behavioral response to ethanol (GO:0048149)3.03942383
65cell migration in hindbrain (GO:0021535)3.03301250
66maturation of SSU-rRNA (GO:0030490)3.01221816
67layer formation in cerebral cortex (GO:0021819)2.98025156
68male meiosis I (GO:0007141)2.96645492
69negative regulation of DNA biosynthetic process (GO:2000279)2.96638554
70regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.96104192
71regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.96104192
72neuronal ion channel clustering (GO:0045161)2.95875496
73cornea development in camera-type eye (GO:0061303)2.93019013
74proteoglycan biosynthetic process (GO:0030166)2.92879863
75diaphragm development (GO:0060539)2.89641020
76endoderm formation (GO:0001706)2.87443997
77skeletal muscle organ development (GO:0060538)2.86458165
78locomotory exploration behavior (GO:0035641)2.82465865
79detection of light stimulus involved in sensory perception (GO:0050962)2.81169969
80detection of light stimulus involved in visual perception (GO:0050908)2.81169969
81neuron maturation (GO:0042551)2.79953469
82positive regulation of cell cycle G2/M phase transition (GO:1902751)2.79519285
83positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.79519285
84cell-cell junction maintenance (GO:0045217)2.77563848
85adult heart development (GO:0007512)2.76513032
86granulocyte differentiation (GO:0030851)2.76381452
87regulation of telomerase activity (GO:0051972)2.73784226
88cellular protein complex disassembly (GO:0043624)2.73363063
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73108013
90establishment of mitochondrion localization (GO:0051654)2.73070801
91peptidyl-lysine methylation (GO:0018022)2.72337993
92inner mitochondrial membrane organization (GO:0007007)2.72327478
93positive regulation of gastrulation (GO:2000543)2.71422233
94translational elongation (GO:0006414)2.71333554
95regulation of activation of Janus kinase activity (GO:0010533)2.69712780
96regulation of histone H3-K4 methylation (GO:0051569)2.69178011
97sequestering of extracellular ligand from receptor (GO:0035581)2.67939842
98DNA topological change (GO:0006265)2.67469875
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65619531
100neurofilament cytoskeleton organization (GO:0060052)10.4260873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.54870708
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.46664048
3ESR1_15608294_ChIP-ChIP_MCF-7_Human4.26627069
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24378866
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.96620510
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85361298
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.76400790
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32118992
9AR_21572438_ChIP-Seq_LNCaP_Human2.22927588
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17283235
11EZH2_22144423_ChIP-Seq_EOC_Human10.8206460
12VDR_22108803_ChIP-Seq_LS180_Human1.86654444
13REST_21632747_ChIP-Seq_MESCs_Mouse1.68339277
14REST_18959480_ChIP-ChIP_MESCs_Mouse1.67704592
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.66311317
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.64505741
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62350770
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.62166284
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.60935646
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.58937893
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.55175747
22TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53254638
23STAT1_20625510_ChIP-Seq_HELA_Human1.52806994
24CTCF_27219007_Chip-Seq_Bcells_Human1.51841935
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50067693
26TAF15_26573619_Chip-Seq_HEK293_Human1.49743765
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49212709
28ZNF274_21170338_ChIP-Seq_K562_Hela1.45987636
29E2F7_22180533_ChIP-Seq_HELA_Human1.43980713
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37794552
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.35197834
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34323257
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33519036
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29861831
35NCOR1_26117541_ChIP-Seq_K562_Human1.29841745
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27475505
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26624180
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.26260901
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24677940
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24607605
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21852486
42TP53_22573176_ChIP-Seq_HFKS_Human1.19383618
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15692071
44MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15407685
45OCT4_20526341_ChIP-Seq_ESCs_Human1.14599850
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10455245
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.09262497
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.06805451
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06551942
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.04211566
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02553366
52NFYA_21822215_ChIP-Seq_K562_Human0.99405711
53P53_21459846_ChIP-Seq_SAOS-2_Human0.98104653
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95721767
55YY1_22570637_ChIP-Seq_MALME-3M_Human0.94038813
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93372719
57GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92468158
58CTCF_20526341_ChIP-Seq_ESCs_Human0.92251101
59ERA_21632823_ChIP-Seq_H3396_Human0.91094237
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90465302
61CIITA_25753668_ChIP-Seq_RAJI_Human0.90450268
62NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89934769
63ERG_20517297_ChIP-Seq_VCAP_Human0.88675037
64EWS_26573619_Chip-Seq_HEK293_Human0.86342746
65FOXH1_21741376_ChIP-Seq_ESCs_Human0.86209051
66RNF2_27304074_Chip-Seq_NSC_Mouse0.85351528
67SOX11_22085726_ChIP-Seq_ESNs_Mouse0.85029436
68ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84596853
69JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83269809
70TAF2_19829295_ChIP-Seq_ESCs_Human0.83262953
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83100804
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82486576
73RARB_27405468_Chip-Seq_BRAIN_Mouse0.81942020
74FOXA1_25329375_ChIP-Seq_VCAP_Human0.81805268
75FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81805268
76GATA6_21074721_ChIP-Seq_CACO-2_Human0.79448888
77E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78722786
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78445119
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.77906111
80SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77818843
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77049822
82TBL1_22424771_ChIP-Seq_293T_Human0.75058239
83NANOG_20526341_ChIP-Seq_ESCs_Human0.74707442
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71989052
85RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71961300
86RAC3_21632823_ChIP-Seq_H3396_Human0.71577131
87BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.71446746
88MYC_18358816_ChIP-ChIP_MESCs_Mouse0.70967882
89JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70848657
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.70738754
91SA1_27219007_Chip-Seq_Bcells_Human0.70373318
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.69541347
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69117496
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.68905735
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68905735
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.68836872
97SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.68690626
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.68638441
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.68535270
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.68512679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting7.02324624
2MP0003123_paternal_imprinting5.69854798
3MP0002160_abnormal_reproductive_system3.54291386
4MP0005083_abnormal_biliary_tract3.52841414
5MP0004885_abnormal_endolymph3.39993232
6MP0002163_abnormal_gland_morphology3.26712476
7MP0009379_abnormal_foot_pigmentation3.12004711
8MP0003646_muscle_fatigue3.03795265
9MP0008995_early_reproductive_senescence3.01880836
10MP0009840_abnormal_foam_cell2.93650487
11MP0001919_abnormal_reproductive_system2.68117603
12MP0008877_abnormal_DNA_methylation2.60455749
13MP0003121_genomic_imprinting2.58755267
14MP0006276_abnormal_autonomic_nervous2.47197747
15MP0005174_abnormal_tail_pigmentation2.45076350
16MP0004133_heterotaxia2.40644159
17MP0000015_abnormal_ear_pigmentation2.36721206
18MP0003172_abnormal_lysosome_physiology2.26753289
19MP0004147_increased_porphyrin_level2.26426942
20MP0009046_muscle_twitch2.19257922
21MP0005389_reproductive_system_phenotype2.05389307
22MP0002928_abnormal_bile_duct1.99777892
23MP0000569_abnormal_digit_pigmentation1.96691867
24MP0003890_abnormal_embryonic-extraembry1.66561256
25MP0002653_abnormal_ependyma_morphology1.63190370
26MP0005379_endocrine/exocrine_gland_phen1.62593070
27MP0005647_abnormal_sex_gland1.62130141
28MP0004019_abnormal_vitamin_homeostasis1.51274921
29MP0006072_abnormal_retinal_apoptosis1.49739056
30MP0003786_premature_aging1.46712933
31MP0004142_abnormal_muscle_tone1.45214388
32MP0002272_abnormal_nervous_system1.41716297
33MP0005075_abnormal_melanosome_morpholog1.34054959
34MP0006292_abnormal_olfactory_placode1.33615403
35MP0004782_abnormal_surfactant_physiolog1.33554671
36MP0002095_abnormal_skin_pigmentation1.32827295
37MP0008875_abnormal_xenobiotic_pharmacok1.32331555
38MP0004859_abnormal_synaptic_plasticity1.31614621
39MP0004134_abnormal_chest_morphology1.28385899
40MP0003880_abnormal_central_pattern1.27099454
41MP0010234_abnormal_vibrissa_follicle1.24065744
42MP0003191_abnormal_cellular_cholesterol1.23765955
43MP0001873_stomach_inflammation1.20209081
44MP0002557_abnormal_social/conspecific_i1.19613392
45MP0001440_abnormal_grooming_behavior1.18957490
46MP0005408_hypopigmentation1.18387554
47MP0004811_abnormal_neuron_physiology1.16017141
48MP0001663_abnormal_digestive_system1.14821946
49MP0004742_abnormal_vestibular_system1.13941445
50MP0000955_abnormal_spinal_cord1.10857499
51MP0002229_neurodegeneration1.07729593
52MP0003137_abnormal_impulse_conducting1.06080866
53MP0003119_abnormal_digestive_system1.04304561
54MP0005381_digestive/alimentary_phenotyp1.00886384
55MP0001529_abnormal_vocalization1.00251172
56MP0002822_catalepsy0.99832636
57MP0008775_abnormal_heart_ventricle0.96904184
58MP0003656_abnormal_erythrocyte_physiolo0.93702938
59MP0002210_abnormal_sex_determination0.91886467
60MP0005253_abnormal_eye_physiology0.91455149
61MP0005360_urolithiasis0.89002563
62MP0004270_analgesia0.88831298
63MP0006035_abnormal_mitochondrial_morpho0.88451836
64MP0002876_abnormal_thyroid_physiology0.88406026
65MP0008058_abnormal_DNA_repair0.83653753
66MP0001727_abnormal_embryo_implantation0.80813115
67MP0003183_abnormal_peptide_metabolism0.79789446
68MP0006036_abnormal_mitochondrial_physio0.79486883
69MP0005409_darkened_coat_color0.78957437
70MP0003806_abnormal_nucleotide_metabolis0.78562541
71MP0003942_abnormal_urinary_system0.78235490
72MP0003283_abnormal_digestive_organ0.75015260
73MP0005551_abnormal_eye_electrophysiolog0.74673372
74MP0000778_abnormal_nervous_system0.74530190
75MP0002882_abnormal_neuron_morphology0.73056281
76MP0003861_abnormal_nervous_system0.70432111
77MP0005646_abnormal_pituitary_gland0.70353241
78MP0004957_abnormal_blastocyst_morpholog0.67549309
79MP0001545_abnormal_hematopoietic_system0.67168530
80MP0005397_hematopoietic_system_phenotyp0.67168530
81MP0002572_abnormal_emotion/affect_behav0.65286759
82MP0003950_abnormal_plasma_membrane0.64208525
83MP0001905_abnormal_dopamine_level0.63926969
84MP0003635_abnormal_synaptic_transmissio0.63633036
85MP0003195_calcinosis0.63465776
86MP0002909_abnormal_adrenal_gland0.62915618
87MP0002752_abnormal_somatic_nervous0.61211689
88MP0001486_abnormal_startle_reflex0.59390057
89MP0000230_abnormal_systemic_arterial0.56244196
90MP0003943_abnormal_hepatobiliary_system0.55750791
91MP0002184_abnormal_innervation0.54985696
92MP0002132_abnormal_respiratory_system0.54569506
93MP0003937_abnormal_limbs/digits/tail_de0.54437988
94MP0001119_abnormal_female_reproductive0.51352107
95MP0005423_abnormal_somatic_nervous0.49436722
96MP0001697_abnormal_embryo_size0.48242592
97MP0001145_abnormal_male_reproductive0.47901883
98MP0005195_abnormal_posterior_eye0.47641838
99MP0003385_abnormal_body_wall0.47407079
100MP0005266_abnormal_metabolism0.47289139

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)5.94918791
2Neonatal hypoglycemia (HP:0001998)4.88347872
3Abnormal pancreas size (HP:0012094)4.86666795
4Hepatoblastoma (HP:0002884)4.65213139
5Acute necrotizing encephalopathy (HP:0006965)4.44619349
6Truncus arteriosus (HP:0001660)4.41264577
7Metaphyseal dysplasia (HP:0100255)4.37077852
83-Methylglutaconic aciduria (HP:0003535)4.35878679
9Supernumerary spleens (HP:0009799)4.27989753
10Abnormality of DNA repair (HP:0003254)4.12295127
11Diastasis recti (HP:0001540)4.12171474
12Duplicated collecting system (HP:0000081)4.10689708
13Acute encephalopathy (HP:0006846)4.05771688
14Abnormal mitochondria in muscle tissue (HP:0008316)4.03310080
15Reticulocytopenia (HP:0001896)4.03256631
16Abnormal number of erythroid precursors (HP:0012131)3.85852743
17Hyperthyroidism (HP:0000836)3.74028954
18Abnormality of the renal collecting system (HP:0004742)3.73764510
19Progressive macrocephaly (HP:0004481)3.71681861
20Congenital malformation of the right heart (HP:0011723)3.64617970
21Double outlet right ventricle (HP:0001719)3.64617970
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63392084
23Abnormality of cells of the erythroid lineage (HP:0012130)3.60719724
24Atrioventricular canal defect (HP:0006695)3.49957291
25Anomalous pulmonary venous return (HP:0010772)3.39355970
26Bony spicule pigmentary retinopathy (HP:0007737)3.35843831
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.30455483
28Septate vagina (HP:0001153)3.30139925
29Chromsome breakage (HP:0040012)3.24491240
30Complete atrioventricular canal defect (HP:0001674)3.23646273
31Absent thumb (HP:0009777)3.01973043
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.98753286
33Molar tooth sign on MRI (HP:0002419)2.98263851
34Abnormality of midbrain morphology (HP:0002418)2.98263851
35Abnormality of the pulmonary veins (HP:0011718)2.93525899
36Abnormal lung lobation (HP:0002101)2.82936399
37Ectopic kidney (HP:0000086)2.76554750
38Type II lissencephaly (HP:0007260)2.73953994
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.72401086
40Meckel diverticulum (HP:0002245)2.69041384
41Entropion (HP:0000621)2.68480909
42Poikiloderma (HP:0001029)2.63815197
43Broad-based gait (HP:0002136)2.62956377
44Enlarged kidneys (HP:0000105)2.60135692
45Mitochondrial inheritance (HP:0001427)2.60089704
46Severe visual impairment (HP:0001141)2.59884495
47Pallor (HP:0000980)2.59280121
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.55319681
49Protruding tongue (HP:0010808)2.54599260
50Cerebral edema (HP:0002181)2.53568638
51Overgrowth (HP:0001548)2.53191117
52Horseshoe kidney (HP:0000085)2.52640241
53Abnormality of the ileum (HP:0001549)2.50530322
54Growth hormone deficiency (HP:0000824)2.50292748
55Neoplasm of the adrenal gland (HP:0100631)2.49791796
56Small intestinal stenosis (HP:0012848)2.40502258
57Duodenal stenosis (HP:0100867)2.40502258
58Abnormality of the preputium (HP:0100587)2.39682264
59Germ cell neoplasia (HP:0100728)2.38511426
60Short tibia (HP:0005736)2.36958057
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.36865851
62Duplication of thumb phalanx (HP:0009942)2.36267640
63Ragged-red muscle fibers (HP:0003200)2.33722071
64Anosmia (HP:0000458)2.33151249
65Clubbing of toes (HP:0100760)2.31594262
66Abnormality of reticulocytes (HP:0004312)2.27348295
67Triphalangeal thumb (HP:0001199)2.25550937
68Adrenal hypoplasia (HP:0000835)2.22525073
69Albinism (HP:0001022)2.20782716
70Asymmetric growth (HP:0100555)2.19398764
71Hypogonadotrophic hypogonadism (HP:0000044)2.19111737
72Abnormality of the aortic arch (HP:0012303)2.17791328
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17575466
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17575466
75Bronchomalacia (HP:0002780)2.16240616
76Increased CSF lactate (HP:0002490)2.15793914
77Abnormal hair whorl (HP:0010721)2.14606016
78Abnormality of chromosome stability (HP:0003220)2.13922720
79Vaginal fistula (HP:0004320)2.13497766
80Abnormality of the duodenum (HP:0002246)2.10357160
81Acute lymphatic leukemia (HP:0006721)2.08589912
82Spastic tetraparesis (HP:0001285)2.02525425
83Dandy-Walker malformation (HP:0001305)1.99722331
84Impaired vibration sensation in the lower limbs (HP:0002166)1.99687128
85Abnormality of the carotid arteries (HP:0005344)1.98344516
86Hypertensive crisis (HP:0100735)1.98219787
87Short thumb (HP:0009778)1.98178669
88Abnormality of the phalanges of the hallux (HP:0010057)1.95028985
89Cutaneous melanoma (HP:0012056)1.93145974
90Large for gestational age (HP:0001520)1.88238821
91Aplasia/Hypoplasia of the thymus (HP:0010515)1.86965657
92Macroglossia (HP:0000158)1.83765171
93Hepatocellular necrosis (HP:0001404)1.83655338
94Microvesicular hepatic steatosis (HP:0001414)1.83456064
95Increased IgE level (HP:0003212)1.79115906
96Acanthocytosis (HP:0001927)1.78454455
97Rectovaginal fistula (HP:0000143)1.77523776
98Rectal fistula (HP:0100590)1.77523776
99Arteriovenous malformation (HP:0100026)1.75812643
100Macrocytic anemia (HP:0001972)1.75042605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.32046484
2BMPR1B4.04402552
3MINK14.02174122
4NTRK33.83779244
5STK38L3.73424214
6EIF2AK12.87657043
7ZAK2.74326337
8CDC72.64276211
9BRSK12.41607736
10NUAK12.39014941
11KSR12.26106402
12PLK42.05091749
13MAPK111.87883178
14BRSK21.87384517
15WEE11.86956543
16PASK1.80815904
17MARK31.71814696
18WNK11.62170813
19RAF11.61327621
20BRD41.55691779
21TYRO31.51491421
22EPHB21.46709825
23PINK11.46582563
24PRKCH1.44727941
25TTK1.42997077
26SIK21.42445599
27CAMK1D1.37240650
28ARAF1.36239040
29STK391.35429784
30CAMKK11.26746495
31CAMK11.23414937
32ADRBK21.19675086
33MARK11.18810372
34CSNK1E1.18129687
35STK381.17600674
36CHEK21.16604792
37NTRK21.13435948
38MARK21.12527219
39MAPK121.10909446
40CSNK1A11.07888225
41KSR21.04135475
42DYRK21.03935195
43MAP4K20.96055071
44PRKCG0.95065440
45BCR0.94761548
46PRKAA10.92809282
47SGK30.88197540
48PIM20.83737726
49TNIK0.81391756
50MAPK130.80661190
51CLK10.80381269
52TEC0.78611294
53PLK10.78267198
54MAP2K10.74569998
55TRIM280.74210645
56CAMK1G0.74133669
57MAPK80.67940006
58MAP2K70.65375840
59ERBB20.62820529
60FRK0.61053771
61GSK3B0.53139073
62MTOR0.52156894
63GRK70.50830760
64PRKCI0.50461241
65CSNK2A20.50458999
66VRK10.50057318
67MAPK140.49615431
68PRKACA0.48073285
69ATM0.44968625
70SGK10.44436163
71CCNB10.43857181
72ATR0.43675095
73RPS6KA50.41293881
74CAMK40.41081215
75CDK10.40697940
76PNCK0.39200295
77AURKA0.38152705
78CDK20.35884656
79ICK0.34188439
80NEK10.33852583
81PRKCQ0.32972572
82EIF2AK20.32825496
83GRK10.32585922
84CDK50.32563172
85CHEK10.31570884
86PRKCZ0.31471572
87MAP3K20.31274252
88STK110.29124889
89AKT10.28883786
90PRKDC0.28540622
91PKN10.26495551
92PAK30.25468894
93ITK0.23522921
94ABL20.22825186
95MAPK90.22522880
96LRRK20.22037259
97PRKACG0.21450559
98ERBB40.20758347
99PRKG10.20580121
100PRKAA20.20075633

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.83784539
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.86569664
3Homologous recombination_Homo sapiens_hsa034404.17947923
4Sulfur relay system_Homo sapiens_hsa041224.03836130
5Ribosome_Homo sapiens_hsa030103.43885402
6Butanoate metabolism_Homo sapiens_hsa006503.29578891
7Oxidative phosphorylation_Homo sapiens_hsa001903.09371784
8Parkinsons disease_Homo sapiens_hsa050122.90253517
9Fanconi anemia pathway_Homo sapiens_hsa034602.79064148
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.11675239
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96847998
12Alzheimers disease_Homo sapiens_hsa050101.96086479
13Steroid biosynthesis_Homo sapiens_hsa001001.81390063
14Cardiac muscle contraction_Homo sapiens_hsa042601.80251010
15Huntingtons disease_Homo sapiens_hsa050161.77839670
16Phototransduction_Homo sapiens_hsa047441.73356429
17Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.60459417
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36237083
19RNA transport_Homo sapiens_hsa030131.32366507
20Ether lipid metabolism_Homo sapiens_hsa005651.26934303
21Taste transduction_Homo sapiens_hsa047421.26353530
22Insulin secretion_Homo sapiens_hsa049111.24486510
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24306047
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23707226
25RNA degradation_Homo sapiens_hsa030181.20186612
26Notch signaling pathway_Homo sapiens_hsa043301.15366860
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.12348266
28mRNA surveillance pathway_Homo sapiens_hsa030151.06682248
29Selenocompound metabolism_Homo sapiens_hsa004501.05715340
30Axon guidance_Homo sapiens_hsa043601.01744691
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98990373
32Steroid hormone biosynthesis_Homo sapiens_hsa001400.96114707
33Retinol metabolism_Homo sapiens_hsa008300.95473779
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94331062
35ABC transporters_Homo sapiens_hsa020100.93034510
36Morphine addiction_Homo sapiens_hsa050320.89462684
37One carbon pool by folate_Homo sapiens_hsa006700.88465371
38Dopaminergic synapse_Homo sapiens_hsa047280.87077414
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85354972
40Hedgehog signaling pathway_Homo sapiens_hsa043400.83362532
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82649984
42Basal transcription factors_Homo sapiens_hsa030220.79881020
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77445038
44Lysine degradation_Homo sapiens_hsa003100.76936616
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76212994
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.75004361
47GABAergic synapse_Homo sapiens_hsa047270.74263934
48Cell cycle_Homo sapiens_hsa041100.74147230
49Cocaine addiction_Homo sapiens_hsa050300.67768473
50Thyroid hormone synthesis_Homo sapiens_hsa049180.66611514
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65864209
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62208227
53Peroxisome_Homo sapiens_hsa041460.61812440
54Regulation of autophagy_Homo sapiens_hsa041400.58510677
55Basal cell carcinoma_Homo sapiens_hsa052170.57128949
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56034412
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55841438
58Metabolic pathways_Homo sapiens_hsa011000.50864627
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50257276
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46950299
61Linoleic acid metabolism_Homo sapiens_hsa005910.46559659
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44336650
63RNA polymerase_Homo sapiens_hsa030200.43821599
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42203224
65Collecting duct acid secretion_Homo sapiens_hsa049660.41296336
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38948423
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35826348
68Nucleotide excision repair_Homo sapiens_hsa034200.34464519
69Gastric acid secretion_Homo sapiens_hsa049710.34139851
70Wnt signaling pathway_Homo sapiens_hsa043100.33039531
71ErbB signaling pathway_Homo sapiens_hsa040120.32392818
72Circadian entrainment_Homo sapiens_hsa047130.31887559
73Alcoholism_Homo sapiens_hsa050340.31315296
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31283485
75p53 signaling pathway_Homo sapiens_hsa041150.31200920
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.30804297
77Fatty acid metabolism_Homo sapiens_hsa012120.30177037
78Cholinergic synapse_Homo sapiens_hsa047250.29743705
79Nicotine addiction_Homo sapiens_hsa050330.28430613
80Calcium signaling pathway_Homo sapiens_hsa040200.27912359
81Serotonergic synapse_Homo sapiens_hsa047260.27290414
82Fat digestion and absorption_Homo sapiens_hsa049750.26161927
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25831946
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23932584
85Oocyte meiosis_Homo sapiens_hsa041140.23242684
86Prolactin signaling pathway_Homo sapiens_hsa049170.22640201
87African trypanosomiasis_Homo sapiens_hsa051430.21945643
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21035243
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20572674
90Synaptic vesicle cycle_Homo sapiens_hsa047210.19448238
91Sphingolipid metabolism_Homo sapiens_hsa006000.19318792
92N-Glycan biosynthesis_Homo sapiens_hsa005100.19067352
93Glutamatergic synapse_Homo sapiens_hsa047240.18422295
94Spliceosome_Homo sapiens_hsa030400.18301760
95cAMP signaling pathway_Homo sapiens_hsa040240.17862561
96Melanogenesis_Homo sapiens_hsa049160.15632302
97Purine metabolism_Homo sapiens_hsa002300.14793861
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14774067
99Ras signaling pathway_Homo sapiens_hsa040140.14293614
100Dorso-ventral axis formation_Homo sapiens_hsa043200.13696490

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