ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of transcription regulatory region DNA binding (GO:2000678)	5.60273476
2	sulfation (GO:0051923)	5.38505245
3	negative regulation of systemic arterial blood pressure (GO:0003085)	5.17902026
4	cellular response to ATP (GO:0071318)	5.16549802
5	response to UV-C (GO:0010225)	4.93777104
6	synapsis (GO:0007129)	4.74679722
7	behavioral response to nicotine (GO:0035095)	4.51566075
8	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.48612865
9	resolution of meiotic recombination intermediates (GO:0000712)	4.35005361
10	water-soluble vitamin biosynthetic process (GO:0042364)	4.33406975
11	regulation of cell proliferation involved in kidney development (GO:1901722)	4.32570370
12	negative regulation of appetite (GO:0032099)	4.23041872
13	negative regulation of response to food (GO:0032096)	4.23041872
14	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.21726473
15	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.21726473
16	cell proliferation in forebrain (GO:0021846)	4.12872843
17	positive regulation of cardiac muscle cell differentiation (GO:2000727)	4.06032703
18	regulation of transcription regulatory region DNA binding (GO:2000677)	4.05123197
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.04924088
20	NADH dehydrogenase complex assembly (GO:0010257)	4.04924088
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.04924088
22	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	4.03257916
23	regulation of glomerulus development (GO:0090192)	3.99224318
24	regulation of DNA endoreduplication (GO:0032875)	3.96923591
25	regulation of phospholipid biosynthetic process (GO:0071071)	3.93359061
26	gamma-aminobutyric acid transport (GO:0015812)	3.91950468
27	tooth mineralization (GO:0034505)	3.91362816
28	positive regulation of cAMP-mediated signaling (GO:0043950)	3.88917324
29	tryptophan catabolic process (GO:0006569)	3.85274035
30	indole-containing compound catabolic process (GO:0042436)	3.85274035
31	indolalkylamine catabolic process (GO:0046218)	3.85274035
32	regulation of posttranscriptional gene silencing (GO:0060147)	3.82672865
33	regulation of gene silencing by miRNA (GO:0060964)	3.82672865
34	regulation of gene silencing by RNA (GO:0060966)	3.82672865
35	pharyngeal system development (GO:0060037)	3.82619617
36	kynurenine metabolic process (GO:0070189)	3.75390595
37	positive regulation of digestive system process (GO:0060456)	3.74694780
38	protein complex biogenesis (GO:0070271)	3.73524110
39	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.73456778
40	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.73456778
41	rRNA modification (GO:0000154)	3.68398060
42	positive regulation of protein autophosphorylation (GO:0031954)	3.67972255
43	otic vesicle formation (GO:0030916)	3.60770751
44	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.57083417
45	regulation of mitotic spindle checkpoint (GO:1903504)	3.57083417
46	mitochondrial respiratory chain complex assembly (GO:0033108)	3.55173048
47	tryptophan metabolic process (GO:0006568)	3.49604117
48	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.47147037
49	rRNA methylation (GO:0031167)	3.47063629
50	flavonoid metabolic process (GO:0009812)	3.45713405
51	negative regulation of telomere maintenance (GO:0032205)	3.44574455
52	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.43549941
53	indolalkylamine metabolic process (GO:0006586)	3.39453999
54	protein polyglutamylation (GO:0018095)	3.39143990
55	respiratory chain complex IV assembly (GO:0008535)	3.32197481
56	estrogen metabolic process (GO:0008210)	3.22322331
57	negative regulation of gene silencing (GO:0060969)	3.22319515
58	negative regulation of mast cell activation (GO:0033004)	3.18182971
59	cytochrome complex assembly (GO:0017004)	3.12068597
60	GPI anchor metabolic process (GO:0006505)	3.09552946
61	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.06558044
62	nucleoside diphosphate catabolic process (GO:0009134)	3.06295931
63	heparin biosynthetic process (GO:0030210)	3.04885039
64	heparin metabolic process (GO:0030202)	3.04885039
65	telomere maintenance via telomerase (GO:0007004)	3.04762088
66	aorta morphogenesis (GO:0035909)	3.04068626
67	cellular anion homeostasis (GO:0030002)	3.02832009
68	positive regulation of fatty acid oxidation (GO:0046321)	2.95361822
69	positive regulation of metanephros development (GO:0072216)	2.92772072
70	replication fork processing (GO:0031297)	2.92416288
71	heme transport (GO:0015886)	2.91359370
72	regulation of DNA damage checkpoint (GO:2000001)	2.91184118
73	negative regulation of multicellular organism growth (GO:0040015)	2.88513910
74	indole-containing compound metabolic process (GO:0042430)	2.79113810
75	centriole replication (GO:0007099)	2.78160754
76	negative regulation of cardiac muscle tissue development (GO:0055026)	2.77548479
77	N-acetylglucosamine metabolic process (GO:0006044)	2.76583090
78	forebrain morphogenesis (GO:0048853)	2.76295019
79	mannosylation (GO:0097502)	2.73604540
80	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.73564795
81	DNA deamination (GO:0045006)	2.72216584
82	negative regulation of platelet activation (GO:0010544)	2.69603425
83	serotonin metabolic process (GO:0042428)	2.69228622
84	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.69156544
85	signal transduction involved in regulation of gene expression (GO:0023019)	2.67611785
86	DNA demethylation (GO:0080111)	2.66268690
87	regulation of cardiac muscle cell contraction (GO:0086004)	2.65735699
88	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.61086987
89	positive regulation of muscle hypertrophy (GO:0014742)	2.61086987
90	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.60880054
91	isotype switching (GO:0045190)	2.57705756
92	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.57705756
93	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.57705756
94	regulation of response to food (GO:0032095)	2.56552941
95	pseudouridine synthesis (GO:0001522)	2.55668087
96	regulation of telomere maintenance (GO:0032204)	2.55193102
97	chromosome organization involved in meiosis (GO:0070192)	2.54699644
98	negative regulation by host of viral transcription (GO:0043922)	2.54666817
99	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.53900657
100	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.53648436

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.52173755
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.55164665
3	VDR_22108803_ChIP-Seq_LS180_Human	3.43710714
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.16804089
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97667510
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.61904005
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55555122
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.52863433
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37700478
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.37012095
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.29519447
12	EWS_26573619_Chip-Seq_HEK293_Human	2.17687016
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14839687
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.11807045
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.05048292
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00011600
17	FUS_26573619_Chip-Seq_HEK293_Human	1.97939986
18	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.79421386
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.75611270
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.73925849
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.69089932
22	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63655293
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.62541469
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.60529657
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.56314939
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.54321945
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.53361806
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.50312453
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47787503
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.47367697
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.47208334
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.46376857
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.44002407
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43080347
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.42527096
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42527096
37	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.42050264
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41399043
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.41377446
40	P300_19829295_ChIP-Seq_ESCs_Human	1.37953630
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33839185
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.32699773
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31810321
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.31730368
45	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31547122
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28576208
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.28406883
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26209233
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.24303317
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.24093621
51	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.23576225
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19997826
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18365398
54	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17734860
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17416878
56	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17233269
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16687212
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14639815
59	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.14621398
60	STAT3_23295773_ChIP-Seq_U87_Human	1.14286494
61	TCF4_23295773_ChIP-Seq_U87_Human	1.11358305
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.10832823
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10022669
64	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09182280
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.08542703
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08451501
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06555658
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03943710
69	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03165001
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02713196
71	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.02620401
72	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.02620401
73	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.02620401
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02549891
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02112143
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02024475
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01109912
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01109912
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00740481
80	TAF15_26573619_Chip-Seq_HEK293_Human	1.00393428
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99327014
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98662780
83	SMAD4_21799915_ChIP-Seq_A2780_Human	0.97716243
84	JUN_21703547_ChIP-Seq_K562_Human	0.97668502
85	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.97362474
86	NCOR_22424771_ChIP-Seq_293T_Human	0.96513830
87	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.96415353
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.95216044
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95147869
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94602150
91	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94537678
92	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94357184
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94162995
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93955096
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93863741
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.93562860
97	IGF1R_20145208_ChIP-Seq_DFB_Human	0.92560162
98	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.91373461
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91056252
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.90409964

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004134_abnormal_chest_morphology	3.92976352
2	MP0002132_abnormal_respiratory_system	3.33199607
3	MP0008872_abnormal_physiological_respon	3.31030379
4	MP0006292_abnormal_olfactory_placode	3.07122821
5	MP0003195_calcinosis	3.03344288
6	MP0004145_abnormal_muscle_electrophysio	2.91645639
7	MP0005083_abnormal_biliary_tract	2.87247016
8	MP0002139_abnormal_hepatobiliary_system	2.74609421
9	MP0004147_increased_porphyrin_level	2.44201944
10	MP0000678_abnormal_parathyroid_gland	2.41093508
11	MP0005646_abnormal_pituitary_gland	2.33216334
12	MP0002938_white_spotting	2.29879865
13	MP0001485_abnormal_pinna_reflex	2.25480438
14	MP0002138_abnormal_hepatobiliary_system	2.24772548
15	MP0009780_abnormal_chondrocyte_physiolo	2.17605019
16	MP0002160_abnormal_reproductive_system	2.13307674
17	MP0000049_abnormal_middle_ear	2.04832969
18	MP0000631_abnormal_neuroendocrine_gland	1.95781974
19	MP0003941_abnormal_skin_development	1.92848176
20	MP0002837_dystrophic_cardiac_calcinosis	1.75302211
21	MP0000569_abnormal_digit_pigmentation	1.73375021
22	MP0009250_abnormal_appendicular_skeleto	1.70777474
23	MP0005551_abnormal_eye_electrophysiolog	1.68863533
24	MP0002876_abnormal_thyroid_physiology	1.66053699
25	MP0004142_abnormal_muscle_tone	1.63268932
26	MP0002734_abnormal_mechanical_nocicepti	1.63011953
27	MP0004270_analgesia	1.60862534
28	MP0004885_abnormal_endolymph	1.60269459
29	MP0005171_absent_coat_pigmentation	1.57155542
30	MP0005503_abnormal_tendon_morphology	1.53517122
31	MP0009046_muscle_twitch	1.53141882
32	MP0003638_abnormal_response/metabolism_	1.50619856
33	MP0002249_abnormal_larynx_morphology	1.47838488
34	MP0003693_abnormal_embryo_hatching	1.41544591
35	MP0003942_abnormal_urinary_system	1.40495848
36	MP0000372_irregular_coat_pigmentation	1.39881455
37	MP0002272_abnormal_nervous_system	1.39740933
38	MP0010094_abnormal_chromosome_stability	1.34295188
39	MP0005360_urolithiasis	1.33784990
40	MP0005389_reproductive_system_phenotype	1.31715064
41	MP0003938_abnormal_ear_development	1.23131295
42	MP0003111_abnormal_nucleus_morphology	1.21714590
43	MP0001984_abnormal_olfaction	1.21391897
44	MP0001905_abnormal_dopamine_level	1.21311225
45	MP0001529_abnormal_vocalization	1.17322601
46	MP0005174_abnormal_tail_pigmentation	1.15793499
47	MP0001542_abnormal_bone_strength	1.12471948
48	MP0003890_abnormal_embryonic-extraembry	1.09346360
49	MP0004133_heterotaxia	1.08959237
50	MP0004215_abnormal_myocardial_fiber	1.08922756
51	MP0008875_abnormal_xenobiotic_pharmacok	1.07229824
52	MP0009745_abnormal_behavioral_response	1.04291750
53	MP0008877_abnormal_DNA_methylation	1.04186490
54	MP0001986_abnormal_taste_sensitivity	1.03464047
55	MP0000516_abnormal_urinary_system	1.03443488
56	MP0005367_renal/urinary_system_phenotyp	1.03443488
57	MP0000733_abnormal_muscle_development	1.03045024
58	MP0001970_abnormal_pain_threshold	1.02475551
59	MP0000613_abnormal_salivary_gland	1.02331645
60	MP0002089_abnormal_postnatal_growth/wei	0.99848248
61	MP0005084_abnormal_gallbladder_morpholo	0.98759029
62	MP0003718_maternal_effect	0.98185244
63	MP0008058_abnormal_DNA_repair	0.98080826
64	MP0002733_abnormal_thermal_nociception	0.97242117
65	MP0001853_heart_inflammation	0.96942362
66	MP0003937_abnormal_limbs/digits/tail_de	0.96489049
67	MP0002064_seizures	0.96014026
68	MP0009384_cardiac_valve_regurgitation	0.92535206
69	MP0002638_abnormal_pupillary_reflex	0.91942894
70	MP0000681_abnormal_thyroid_gland	0.91140387
71	MP0005636_abnormal_mineral_homeostasis	0.89491154
72	MP0001661_extended_life_span	0.88183925
73	MP0005310_abnormal_salivary_gland	0.87183520
74	MP0001968_abnormal_touch/_nociception	0.86093565
75	MP0003755_abnormal_palate_morphology	0.85929304
76	MP0003646_muscle_fatigue	0.85229624
77	MP0004130_abnormal_muscle_cell	0.84133106
78	MP0002928_abnormal_bile_duct	0.80937407
79	MP0002295_abnormal_pulmonary_circulatio	0.79348129
80	MP0002234_abnormal_pharynx_morphology	0.78737536
81	MP0003567_abnormal_fetal_cardiomyocyte	0.76588442
82	MP0005410_abnormal_fertilization	0.76331071
83	MP0008995_early_reproductive_senescence	0.75806648
84	MP0001963_abnormal_hearing_physiology	0.74291471
85	MP0002254_reproductive_system_inflammat	0.72499400
86	MP0001177_atelectasis	0.72110153
87	MP0005365_abnormal_bile_salt	0.70831040
88	MP0004484_altered_response_of	0.69857914
89	MP0001486_abnormal_startle_reflex	0.69334181
90	MP0006072_abnormal_retinal_apoptosis	0.68498842
91	MP0005253_abnormal_eye_physiology	0.67585771
92	MP0003119_abnormal_digestive_system	0.67486701
93	MP0002277_abnormal_respiratory_mucosa	0.65911573
94	MP0001145_abnormal_male_reproductive	0.64776892
95	MP0002163_abnormal_gland_morphology	0.64582646
96	MP0010386_abnormal_urinary_bladder	0.62515094
97	MP0001929_abnormal_gametogenesis	0.62434456
98	MP0009765_abnormal_xenobiotic_induced	0.59175966
99	MP0002111_abnormal_tail_morphology	0.58948560
100	MP0000163_abnormal_cartilage_morphology	0.57796783

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	5.10590751
2	Abnormality of homocysteine metabolism (HP:0010919)	4.28542468
3	Homocystinuria (HP:0002156)	4.28542468
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.08914038
5	Short middle phalanx of the 5th finger (HP:0004220)	4.08626892
6	Pancreatic fibrosis (HP:0100732)	3.93608190
7	Pancreatic cysts (HP:0001737)	3.88970646
8	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.82064629
9	Decreased central vision (HP:0007663)	3.66571344
10	Abnormality of the phalanges of the 5th finger (HP:0004213)	3.48239184
11	True hermaphroditism (HP:0010459)	3.46691390
12	Confusion (HP:0001289)	3.29464772
13	Acanthocytosis (HP:0001927)	3.15278836
14	Severe visual impairment (HP:0001141)	3.14620123
15	Abolished electroretinogram (ERG) (HP:0000550)	3.06481328
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.05654035
17	Acute necrotizing encephalopathy (HP:0006965)	3.00921331
18	Abnormality of chromosome stability (HP:0003220)	2.97022709
19	Methylmalonic acidemia (HP:0002912)	2.95506624
20	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.93482042
21	Increased corneal curvature (HP:0100692)	2.88260433
22	Keratoconus (HP:0000563)	2.88260433
23	Hyperthyroidism (HP:0000836)	2.82892551
24	Progressive macrocephaly (HP:0004481)	2.82553623
25	Furrowed tongue (HP:0000221)	2.77316045
26	Methylmalonic aciduria (HP:0012120)	2.72626585
27	Type II lissencephaly (HP:0007260)	2.70724607
28	Conjunctival hamartoma (HP:0100780)	2.61822036
29	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.61400906
30	Congenital sensorineural hearing impairment (HP:0008527)	2.57298426
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.56650331
32	Gaze-evoked nystagmus (HP:0000640)	2.55453078
33	Hamartoma of the eye (HP:0010568)	2.48701680
34	Ependymoma (HP:0002888)	2.48469907
35	Hypoplastic pelvis (HP:0008839)	2.48218275
36	Genetic anticipation (HP:0003743)	2.44860540
37	Attenuation of retinal blood vessels (HP:0007843)	2.44147141
38	Abnormality of cochlea (HP:0000375)	2.44066332
39	Mitochondrial inheritance (HP:0001427)	2.40619962
40	Porencephaly (HP:0002132)	2.40511872
41	Sclerocornea (HP:0000647)	2.37610504
42	Agitation (HP:0000713)	2.36715443
43	Cystic liver disease (HP:0006706)	2.35912308
44	Acute encephalopathy (HP:0006846)	2.32649913
45	Hypoplastic iliac wings (HP:0002866)	2.31544757
46	Hemiplegia (HP:0002301)	2.30281320
47	Protruding tongue (HP:0010808)	2.29585823
48	Abnormality of ocular smooth pursuit (HP:0000617)	2.27783602
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27543344
50	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.27134491
51	Progressive cerebellar ataxia (HP:0002073)	2.24311091
52	Anencephaly (HP:0002323)	2.23721537
53	Asplenia (HP:0001746)	2.23104823
54	Abnormality of methionine metabolism (HP:0010901)	2.15775004
55	Increased CSF lactate (HP:0002490)	2.15611801
56	Duodenal stenosis (HP:0100867)	2.12734140
57	Small intestinal stenosis (HP:0012848)	2.12734140
58	Meckel diverticulum (HP:0002245)	2.08472914
59	Short 5th finger (HP:0009237)	2.08024977
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05485510
61	Impaired smooth pursuit (HP:0007772)	2.03728414
62	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.03227422
63	Oral leukoplakia (HP:0002745)	2.02627821
64	Septo-optic dysplasia (HP:0100842)	2.01443798
65	Abnormality of vitamin B metabolism (HP:0004340)	2.00048447
66	Visual hallucinations (HP:0002367)	1.99709694
67	Long nose (HP:0003189)	1.99089671
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98955248
69	Hypoplasia of the pons (HP:0012110)	1.98231163
70	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.97289493
71	Congenital, generalized hypertrichosis (HP:0004540)	1.94839849
72	3-Methylglutaconic aciduria (HP:0003535)	1.94242057
73	Abnormality of the ileum (HP:0001549)	1.93371031
74	Hepatocellular necrosis (HP:0001404)	1.92807722
75	Chromsome breakage (HP:0040012)	1.92062567
76	Angiofibromas (HP:0010615)	1.91571907
77	Adenoma sebaceum (HP:0009720)	1.91571907
78	Abnormality of the renal collecting system (HP:0004742)	1.91377200
79	Abnormality of DNA repair (HP:0003254)	1.90411421
80	Hepatic necrosis (HP:0002605)	1.88619858
81	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.87560152
82	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.86197217
83	Abnormality of the preputium (HP:0100587)	1.86159390
84	Hypoglycemic coma (HP:0001325)	1.86087273
85	Abnormality of the duodenum (HP:0002246)	1.86002720
86	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.85969102
87	Poikilocytosis (HP:0004447)	1.85449725
88	Abnormality of the pons (HP:0007361)	1.85131017
89	Redundant skin (HP:0001582)	1.84277309
90	Hyperinsulinemic hypoglycemia (HP:0000825)	1.83387927
91	Renal cortical cysts (HP:0000803)	1.82846631
92	Aplastic anemia (HP:0001915)	1.82167403
93	Morphological abnormality of the inner ear (HP:0011390)	1.81725731
94	Abnormal protein glycosylation (HP:0012346)	1.81592744
95	Abnormal glycosylation (HP:0012345)	1.81592744
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.81592744
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.81592744
98	Hemiparesis (HP:0001269)	1.81092509
99	Absent thumb (HP:0009777)	1.77588754
100	Anal atresia (HP:0002023)	1.76146115

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.61896509
2	INSRR	3.56884292
3	PDK2	3.29606035
4	ADRBK2	3.19066445
5	GRK1	3.03023795
6	MAP4K2	2.62807655
7	TAOK3	2.45747525
8	PLK4	2.34348907
9	NUAK1	2.26175451
10	VRK2	2.25960115
11	STK4	2.25015894
12	CLK1	2.23178847
13	PRKD2	2.18209451
14	TNIK	2.11935823
15	PAK3	2.11601980
16	MST4	2.06742176
17	BMPR1B	2.04325228
18	EPHA3	1.96512538
19	BRSK2	1.92354949
20	STK3	1.81009285
21	CDC7	1.65147742
22	ZAK	1.43813480
23	FGFR2	1.43164669
24	WNK3	1.38519944
25	MAP3K4	1.37781443
26	PBK	1.37258412
27	TAF1	1.31147210
28	VRK1	1.22664904
29	PINK1	1.22219230
30	PLK2	1.21376677
31	CDK8	1.04482745
32	PLK3	1.03019259
33	GRK7	0.97193939
34	OXSR1	0.93099988
35	PKN1	0.90804892
36	MAP2K7	0.88181665
37	FER	0.85205501
38	CHEK2	0.83893838
39	MAPKAPK5	0.83020057
40	TXK	0.82401786
41	PRKCG	0.78697542
42	PRKCI	0.76883576
43	ATR	0.73868223
44	RPS6KA5	0.71019156
45	PRKCE	0.69640390
46	BMPR2	0.69352852
47	AKT3	0.66823597
48	EPHA4	0.66717964
49	MAPK13	0.63530759
50	ACVR1B	0.62972724
51	WNK4	0.61628450
52	ILK	0.60985495
53	TRPM7	0.59992008
54	NLK	0.59751566
55	STK24	0.59318231
56	CSNK1A1	0.57447921
57	GRK5	0.57106499
58	PTK2B	0.56120954
59	SRPK1	0.55199309
60	MUSK	0.54419697
61	PLK1	0.54364695
62	TLK1	0.54124850
63	STK16	0.53692102
64	TTK	0.53152360
65	MKNK2	0.51819610
66	PRKD1	0.50850916
67	MAP3K7	0.48321839
68	AURKB	0.47976877
69	NME1	0.46619181
70	DYRK2	0.46423213
71	PRKAA1	0.44591184
72	STK39	0.43757816
73	TEC	0.43583466
74	ABL1	0.42985963
75	ATM	0.42481360
76	CDK3	0.41881594
77	PIM1	0.41845792
78	CAMK1	0.41680634
79	MARK3	0.41573351
80	CHEK1	0.40631410
81	NEK1	0.40271635
82	DAPK2	0.39474069
83	BLK	0.39241298
84	PRKCA	0.39195219
85	ADRBK1	0.38124222
86	IKBKB	0.37975256
87	ERBB2	0.36632720
88	FGFR3	0.36117051
89	CAMK2A	0.36077048
90	STK11	0.35808634
91	BRSK1	0.35439615
92	CDC42BPA	0.33874761
93	PRKAA2	0.33349470
94	PRKACA	0.32822627
95	SGK1	0.32792267
96	DAPK3	0.32340830
97	CSNK1D	0.31985420
98	CDK9	0.31628252
99	PRKDC	0.29709498
100	PRKCH	0.29695273

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.62621787
2	Homologous recombination_Homo sapiens_hsa03440	3.39666601
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.28338255
4	One carbon pool by folate_Homo sapiens_hsa00670	3.00633132
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.68912689
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.46529070
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20567709
8	DNA replication_Homo sapiens_hsa03030	2.16588434
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.05034726
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.04032137
11	RNA polymerase_Homo sapiens_hsa03020	1.86698729
12	Parkinsons disease_Homo sapiens_hsa05012	1.86522959
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.84781601
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81248282
15	Nicotine addiction_Homo sapiens_hsa05033	1.80767111
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.72812676
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.71226288
18	Protein export_Homo sapiens_hsa03060	1.71213527
19	Phototransduction_Homo sapiens_hsa04744	1.69022697
20	Melanoma_Homo sapiens_hsa05218	1.61946804
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.57482989
22	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.54650108
23	Butanoate metabolism_Homo sapiens_hsa00650	1.54557572
24	Proteasome_Homo sapiens_hsa03050	1.54146797
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51603167
26	Basal transcription factors_Homo sapiens_hsa03022	1.51167818
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46925269
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43447941
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.38569404
30	Taste transduction_Homo sapiens_hsa04742	1.38162209
31	Sulfur metabolism_Homo sapiens_hsa00920	1.36899937
32	Huntingtons disease_Homo sapiens_hsa05016	1.36512438
33	Mismatch repair_Homo sapiens_hsa03430	1.36032850
34	RNA degradation_Homo sapiens_hsa03018	1.35950867
35	Alzheimers disease_Homo sapiens_hsa05010	1.28666177
36	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.19992882
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18926780
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15174506
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.11977069
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11715274
41	RNA transport_Homo sapiens_hsa03013	1.06724368
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.04742027
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03346597
44	Spliceosome_Homo sapiens_hsa03040	0.97865590
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96895656
46	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.96472124
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94203259
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.92395208
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91328571
50	Insulin secretion_Homo sapiens_hsa04911	0.90517309
51	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.90409552
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90122714
53	Olfactory transduction_Homo sapiens_hsa04740	0.89994209
54	Morphine addiction_Homo sapiens_hsa05032	0.86375866
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85779118
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.85588725
57	Fatty acid elongation_Homo sapiens_hsa00062	0.85263581
58	Retinol metabolism_Homo sapiens_hsa00830	0.81614733
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.80984826
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79233651
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.78960171
62	Purine metabolism_Homo sapiens_hsa00230	0.77340913
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.77130483
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.74430082
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70474953
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70157191
67	Base excision repair_Homo sapiens_hsa03410	0.69990344
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69470734
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69054447
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.68831430
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68601711
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64387032
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.63704855
74	Mineral absorption_Homo sapiens_hsa04978	0.61805337
75	Glutathione metabolism_Homo sapiens_hsa00480	0.60513526
76	Type II diabetes mellitus_Homo sapiens_hsa04930	0.59206992
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57512935
78	Renin-angiotensin system_Homo sapiens_hsa04614	0.55971459
79	Metabolic pathways_Homo sapiens_hsa01100	0.55364633
80	Propanoate metabolism_Homo sapiens_hsa00640	0.53436303
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50946836
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50646029
83	Alcoholism_Homo sapiens_hsa05034	0.46127803
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45558845
85	Caffeine metabolism_Homo sapiens_hsa00232	0.44323390
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.44037199
87	Peroxisome_Homo sapiens_hsa04146	0.43049291
88	Serotonergic synapse_Homo sapiens_hsa04726	0.42857641
89	GABAergic synapse_Homo sapiens_hsa04727	0.42463210
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.42130348
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41385667
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.38570885
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.37687121
94	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.36263242
95	Regulation of autophagy_Homo sapiens_hsa04140	0.35652867
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34316623
97	ABC transporters_Homo sapiens_hsa02010	0.34253874
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32859242
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.29547496
100	Salivary secretion_Homo sapiens_hsa04970	0.28860108

OR8B5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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