OR8B7P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1coenzyme catabolic process (GO:0009109)8.50753873
2one-carbon compound transport (GO:0019755)7.15804056
3polyol transport (GO:0015791)5.74833727
4cofactor catabolic process (GO:0051187)4.93596255
5cellular response to ATP (GO:0071318)4.81547718
6positive regulation of histone H3-K4 methylation (GO:0051571)4.54451224
7auditory receptor cell stereocilium organization (GO:0060088)4.43618762
8synapsis (GO:0007129)4.32322111
9positive regulation of gluconeogenesis (GO:0045722)4.06559804
10DNA double-strand break processing (GO:0000729)4.04599802
11phosphatidylinositol acyl-chain remodeling (GO:0036149)3.91023580
12negative regulation of macrophage differentiation (GO:0045650)3.82729866
13regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.80269318
14cell proliferation in forebrain (GO:0021846)3.78367853
15regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.78031248
16positive regulation of prostaglandin secretion (GO:0032308)3.77879222
17protein neddylation (GO:0045116)3.75848944
18regulation of DNA endoreduplication (GO:0032875)3.68486718
19regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.67659943
20detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.66454382
21negative regulation of T cell differentiation in thymus (GO:0033085)3.65746956
22forebrain morphogenesis (GO:0048853)3.65124545
23positive regulation of cAMP-mediated signaling (GO:0043950)3.65076072
24negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.63758246
25regulation of prostaglandin secretion (GO:0032306)3.60565553
26spermatid nucleus differentiation (GO:0007289)3.60521569
27negative regulation of dendrite development (GO:2000171)3.47695411
28regulation of glomerulus development (GO:0090192)3.44077982
29behavioral response to nicotine (GO:0035095)3.41257747
30inner ear receptor stereocilium organization (GO:0060122)3.32583152
31nephron tubule development (GO:0072080)3.27392133
32preassembly of GPI anchor in ER membrane (GO:0016254)3.26626863
33ATP synthesis coupled proton transport (GO:0015986)3.26510492
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26510492
35sulfation (GO:0051923)3.25823982
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.24990462
37regulation of phospholipid biosynthetic process (GO:0071071)3.24202751
38male meiosis I (GO:0007141)3.21617738
39negative regulation of transcription regulatory region DNA binding (GO:2000678)3.21346769
40GTP biosynthetic process (GO:0006183)3.18469504
41negative regulation of histone acetylation (GO:0035067)3.16573883
42rRNA modification (GO:0000154)3.14006184
43negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.11661908
44regulation of cell proliferation involved in kidney development (GO:1901722)3.11634516
45phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.11340906
46C-terminal protein lipidation (GO:0006501)3.08755161
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03965706
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03767526
49positive regulation of fatty acid transport (GO:2000193)3.03116313
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02579381
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02579381
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.02579381
53proteasome assembly (GO:0043248)2.98527222
54histone H3-K9 methylation (GO:0051567)2.97771068
55positive regulation of triglyceride biosynthetic process (GO:0010867)2.96883416
56detection of light stimulus involved in sensory perception (GO:0050962)2.94385266
57detection of light stimulus involved in visual perception (GO:0050908)2.94385266
58renal tubule development (GO:0061326)2.94359981
59centriole replication (GO:0007099)2.92407828
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.90639143
61pharyngeal system development (GO:0060037)2.90262911
62regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.87982278
63rRNA methylation (GO:0031167)2.86650301
64sensory perception of smell (GO:0007608)2.85985277
65positive regulation of icosanoid secretion (GO:0032305)2.84950472
66phosphatidylserine acyl-chain remodeling (GO:0036150)2.83477641
67UTP biosynthetic process (GO:0006228)2.83166767
68purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.82386717
693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.82386717
70regulation of cell maturation (GO:1903429)2.73705032
71flavonoid metabolic process (GO:0009812)2.72580646
72DNA deamination (GO:0045006)2.72401921
73negative regulation of lipid storage (GO:0010888)2.71934907
74regulation of acrosome reaction (GO:0060046)2.70746920
75G-protein coupled receptor internalization (GO:0002031)2.68510839
76water-soluble vitamin biosynthetic process (GO:0042364)2.67300797
77photoreceptor cell maintenance (GO:0045494)2.66517507
78negative regulation of appetite (GO:0032099)2.63950995
79negative regulation of response to food (GO:0032096)2.63950995
80negative regulation of JAK-STAT cascade (GO:0046426)2.62803096
81oxygen transport (GO:0015671)2.62131505
82chromosome organization involved in meiosis (GO:0070192)2.60395948
83interkinetic nuclear migration (GO:0022027)2.60353368
84glycerol ether metabolic process (GO:0006662)2.59879697
85cellular ketone body metabolic process (GO:0046950)2.59855517
86dentate gyrus development (GO:0021542)2.58487347
87regulation of female receptivity (GO:0045924)2.58409378
88positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58376137
89detection of chemical stimulus involved in sensory perception (GO:0050907)2.57948877
90epithelial cell fate commitment (GO:0072148)2.57574638
91indolalkylamine metabolic process (GO:0006586)2.57333973
92regulation of nuclear cell cycle DNA replication (GO:0033262)2.57032956
93negative regulation of protein acetylation (GO:1901984)2.55991265
94maturation of 5.8S rRNA (GO:0000460)2.55541311
95C-terminal protein amino acid modification (GO:0018410)2.55141714
96negative regulation of platelet activation (GO:0010544)2.53014198
97ether lipid metabolic process (GO:0046485)2.51948205
98regulation of Golgi to plasma membrane protein transport (GO:0042996)2.51402287
99regulation of stem cell maintenance (GO:2000036)2.50484974
100forebrain neuron development (GO:0021884)2.50392424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.11205542
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.74956702
3VDR_22108803_ChIP-Seq_LS180_Human3.40829769
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76170141
5EWS_26573619_Chip-Seq_HEK293_Human2.72794978
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72166989
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65128914
8ZNF274_21170338_ChIP-Seq_K562_Hela2.62018428
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60913869
10GBX2_23144817_ChIP-Seq_PC3_Human2.55155256
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42176569
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20241051
13IRF1_19129219_ChIP-ChIP_H3396_Human2.19691986
14FUS_26573619_Chip-Seq_HEK293_Human2.18884176
15MYC_18940864_ChIP-ChIP_HL60_Human2.18250786
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07695448
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.06532398
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05432051
19CBP_20019798_ChIP-Seq_JUKART_Human1.99785739
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.99785739
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.90847616
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87639851
23P300_19829295_ChIP-Seq_ESCs_Human1.85652990
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84178297
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.78432254
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71594006
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71398156
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66263327
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66263327
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66263327
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.62720985
32EZH2_22144423_ChIP-Seq_EOC_Human1.62508041
33ER_23166858_ChIP-Seq_MCF-7_Human1.61868807
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53405151
35BCAT_22108803_ChIP-Seq_LS180_Human1.50180640
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47298421
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46501824
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46046676
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44780240
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43020319
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40691489
42NCOR_22424771_ChIP-Seq_293T_Human1.40247633
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37589036
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36581670
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.35922107
46SMAD4_21799915_ChIP-Seq_A2780_Human1.33290200
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30923661
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.29050048
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28320988
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27777478
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26069907
52IGF1R_20145208_ChIP-Seq_DFB_Human1.24509304
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24273942
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23326680
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22974048
56TCF4_22108803_ChIP-Seq_LS180_Human1.22826596
57TCF4_23295773_ChIP-Seq_U87_Human1.21497612
58NANOG_19829295_ChIP-Seq_ESCs_Human1.21013485
59SOX2_19829295_ChIP-Seq_ESCs_Human1.21013485
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18786778
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.18489371
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18489371
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18476829
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17334631
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16908103
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16346269
67SCL_19346495_ChIP-Seq_HPC-7_Human1.15874311
68STAT3_23295773_ChIP-Seq_U87_Human1.15205390
69RNF2_27304074_Chip-Seq_NSC_Mouse1.13806064
70TP53_16413492_ChIP-PET_HCT116_Human1.11988238
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.11587114
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10875798
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.10636480
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10049332
75TAF15_26573619_Chip-Seq_HEK293_Human1.09710605
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09697432
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08384990
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06989916
79JUN_21703547_ChIP-Seq_K562_Human1.06083017
80ETV1_20927104_ChIP-Seq_GIST48_Human1.04798846
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.04419421
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.03660397
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03129185
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02636694
85CDX2_22108803_ChIP-Seq_LS180_Human1.02216328
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01040105
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.00758563
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.00517760
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98992133
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.98688693
91RUNX2_22187159_ChIP-Seq_PCA_Human0.98602275
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98226459
93ESET_19884257_ChIP-Seq_ESCs_Mouse0.97830391
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97753083
95ELK1_19687146_ChIP-ChIP_HELA_Human0.95665093
96P53_22387025_ChIP-Seq_ESCs_Mouse0.95046802
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.94638728
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.93741579
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93580573
100P300_18555785_Chip-Seq_ESCs_Mouse0.93564975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph4.30455897
2MP0002138_abnormal_hepatobiliary_system3.94944807
3MP0003195_calcinosis3.86548104
4MP0008057_abnormal_DNA_replication3.01564015
5MP0002160_abnormal_reproductive_system2.67911498
6MP0005410_abnormal_fertilization2.45385980
7MP0005646_abnormal_pituitary_gland2.37358801
8MP0000678_abnormal_parathyroid_gland2.33306013
9MP0005360_urolithiasis2.22735545
10MP0006292_abnormal_olfactory_placode2.22018185
11MP0004134_abnormal_chest_morphology2.18136454
12MP0009840_abnormal_foam_cell2.12542710
13MP0004147_increased_porphyrin_level1.95895777
14MP0001968_abnormal_touch/_nociception1.95657846
15MP0006276_abnormal_autonomic_nervous1.93901942
16MP0002928_abnormal_bile_duct1.91701562
17MP0002009_preneoplasia1.90315838
18MP0005389_reproductive_system_phenotype1.88682257
19MP0000566_synostosis1.85705108
20MP0001188_hyperpigmentation1.81452594
21MP0008872_abnormal_physiological_respon1.65012421
22MP0000631_abnormal_neuroendocrine_gland1.63471372
23MP0002736_abnormal_nociception_after1.60464881
24MP0005551_abnormal_eye_electrophysiolog1.59464112
25MP0000372_irregular_coat_pigmentation1.58918781
26MP0004742_abnormal_vestibular_system1.57579020
27MP0010094_abnormal_chromosome_stability1.57432451
28MP0005397_hematopoietic_system_phenotyp1.56330000
29MP0001545_abnormal_hematopoietic_system1.56330000
30MP0002139_abnormal_hepatobiliary_system1.55898170
31MP0005332_abnormal_amino_acid1.53618674
32MP0005174_abnormal_tail_pigmentation1.51252861
33MP0008877_abnormal_DNA_methylation1.50054744
34MP0005645_abnormal_hypothalamus_physiol1.49664234
35MP0001664_abnormal_digestion1.49397307
36MP0009250_abnormal_appendicular_skeleto1.46768633
37MP0002653_abnormal_ependyma_morphology1.46413093
38MP0004145_abnormal_muscle_electrophysio1.45492464
39MP0000681_abnormal_thyroid_gland1.44805024
40MP0002166_altered_tumor_susceptibility1.42934736
41MP0003950_abnormal_plasma_membrane1.41428821
42MP0003718_maternal_effect1.37485908
43MP0000049_abnormal_middle_ear1.34332165
44MP0003646_muscle_fatigue1.34128248
45MP0005084_abnormal_gallbladder_morpholo1.31713894
46MP0009780_abnormal_chondrocyte_physiolo1.31223296
47MP0008007_abnormal_cellular_replicative1.27353977
48MP0002734_abnormal_mechanical_nocicepti1.26949359
49MP0009278_abnormal_bone_marrow1.25560000
50MP0003880_abnormal_central_pattern1.24655744
51MP0002876_abnormal_thyroid_physiology1.23921183
52MP0005367_renal/urinary_system_phenotyp1.20262828
53MP0000516_abnormal_urinary_system1.20262828
54MP0003186_abnormal_redox_activity1.19717361
55MP0005365_abnormal_bile_salt1.18391983
56MP0001919_abnormal_reproductive_system1.14258316
57MP0005220_abnormal_exocrine_pancreas1.13466752
58MP0002735_abnormal_chemical_nociception1.11189320
59MP0004484_altered_response_of1.11114619
60MP0001485_abnormal_pinna_reflex1.10237410
61MP0004215_abnormal_myocardial_fiber1.09329936
62MP0002837_dystrophic_cardiac_calcinosis1.09293252
63MP0001929_abnormal_gametogenesis1.09206079
64MP0008995_early_reproductive_senescence1.07174056
65MP0009697_abnormal_copulation1.06154313
66MP0003183_abnormal_peptide_metabolism1.03911177
67MP0005253_abnormal_eye_physiology1.03805525
68MP0002272_abnormal_nervous_system1.02846015
69MP0002163_abnormal_gland_morphology1.01579750
70MP0003638_abnormal_response/metabolism_0.99754315
71MP0003698_abnormal_male_reproductive0.98016166
72MP0002006_tumorigenesis0.92282684
73MP0009745_abnormal_behavioral_response0.90461637
74MP0000470_abnormal_stomach_morphology0.88043625
75MP0001970_abnormal_pain_threshold0.85736246
76MP0002909_abnormal_adrenal_gland0.85661189
77MP0000613_abnormal_salivary_gland0.85047965
78MP0002210_abnormal_sex_determination0.83959907
79MP0002234_abnormal_pharynx_morphology0.83215962
80MP0001270_distended_abdomen0.82364108
81MP0003787_abnormal_imprinting0.80914609
82MP0006072_abnormal_retinal_apoptosis0.80805659
83MP0005448_abnormal_energy_balance0.80716140
84MP0001944_abnormal_pancreas_morphology0.79210334
85MP0001905_abnormal_dopamine_level0.78899153
86MP0001145_abnormal_male_reproductive0.78834284
87MP0001879_abnormal_lymphatic_vessel0.78788380
88MP0002132_abnormal_respiratory_system0.78215622
89MP0001963_abnormal_hearing_physiology0.76727593
90MP0001502_abnormal_circadian_rhythm0.74502010
91MP0003937_abnormal_limbs/digits/tail_de0.73919066
92MP0000653_abnormal_sex_gland0.73817280
93MP0002733_abnormal_thermal_nociception0.73691616
94MP0010678_abnormal_skin_adnexa0.72674180
95MP0003252_abnormal_bile_duct0.72396876
96MP0000538_abnormal_urinary_bladder0.72110086
97MP0001119_abnormal_female_reproductive0.69767316
98MP0005075_abnormal_melanosome_morpholog0.69288957
99MP0002938_white_spotting0.69219001
100MP0000383_abnormal_hair_follicle0.68322999

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)8.21934242
2Absent/shortened dynein arms (HP:0200106)7.01748766
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.01748766
4Decreased central vision (HP:0007663)6.68868545
5Abnormal rod and cone electroretinograms (HP:0008323)5.70033198
6Bony spicule pigmentary retinopathy (HP:0007737)4.57537683
7Attenuation of retinal blood vessels (HP:0007843)4.12903831
8Abnormal ciliary motility (HP:0012262)3.84907673
9Constricted visual fields (HP:0001133)3.65601909
10Pendular nystagmus (HP:0012043)3.61018369
11Abnormal respiratory motile cilium morphology (HP:0005938)3.58864968
12Abnormal respiratory epithelium morphology (HP:0012253)3.58864968
13Type II lissencephaly (HP:0007260)3.50471935
14Conjunctival hamartoma (HP:0100780)3.47590190
15Abolished electroretinogram (ERG) (HP:0000550)3.43906606
16Pancreatic cysts (HP:0001737)3.25759316
17Abnormal respiratory motile cilium physiology (HP:0012261)3.22069833
18Hyperglycinuria (HP:0003108)3.18450755
19True hermaphroditism (HP:0010459)3.16690408
20Pancreatic fibrosis (HP:0100732)3.10038036
213-Methylglutaconic aciduria (HP:0003535)3.02560351
22Keratoconus (HP:0000563)2.95643032
23Increased corneal curvature (HP:0100692)2.95643032
24Renal cortical cysts (HP:0000803)2.84282609
25Abnormal biliary tract physiology (HP:0012439)2.82819104
26Bile duct proliferation (HP:0001408)2.82819104
27Furrowed tongue (HP:0000221)2.72292109
28Abnormality of cochlea (HP:0000375)2.63946570
29Abnormality of the renal cortex (HP:0011035)2.62815730
30Molar tooth sign on MRI (HP:0002419)2.53689153
31Abnormality of midbrain morphology (HP:0002418)2.53689153
32Goiter (HP:0000853)2.45489108
33Generalized aminoaciduria (HP:0002909)2.42668932
34Methylmalonic acidemia (HP:0002912)2.40075435
35Chorioretinal atrophy (HP:0000533)2.39614128
36Progressive macrocephaly (HP:0004481)2.38855879
37Congenital stationary night blindness (HP:0007642)2.38270960
38Acute encephalopathy (HP:0006846)2.38159348
39Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.33330790
40Confusion (HP:0001289)2.30476290
41Hypoplasia of the uterus (HP:0000013)2.26959947
42Bone cyst (HP:0012062)2.26060693
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21240776
44Abnormality of glycine metabolism (HP:0010895)2.21071114
45Abnormality of serine family amino acid metabolism (HP:0010894)2.21071114
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20066119
47Hamartoma of the eye (HP:0010568)2.17544280
48Hyperthyroidism (HP:0000836)2.15888445
49Nephronophthisis (HP:0000090)2.15421186
50Cystic liver disease (HP:0006706)2.10470941
51Abnormality of the phalanges of the 5th finger (HP:0004213)2.08667194
52Abnormality of the nasal septum (HP:0000419)2.08565583
53Cerebral edema (HP:0002181)2.07425502
54Abnormal hemoglobin (HP:0011902)2.06396081
55Neoplasm of the adrenal cortex (HP:0100641)2.05091327
56Morphological abnormality of the inner ear (HP:0011390)2.05079458
57Severe visual impairment (HP:0001141)2.04522108
58Acute necrotizing encephalopathy (HP:0006965)2.03789172
59Respiratory difficulties (HP:0002880)2.02959012
60Supernumerary spleens (HP:0009799)1.98769410
61Hemiparesis (HP:0001269)1.97962581
62Absent thumb (HP:0009777)1.94502705
63Abnormality of the renal medulla (HP:0100957)1.91735454
64Methylmalonic aciduria (HP:0012120)1.83654398
65Lissencephaly (HP:0001339)1.79760185
66Male pseudohermaphroditism (HP:0000037)1.79183113
67Gonadal dysgenesis (HP:0000133)1.78340901
68Abnormal drinking behavior (HP:0030082)1.77173039
69Polydipsia (HP:0001959)1.77173039
70Abnormality of the fingertips (HP:0001211)1.76299133
71Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76176094
72Dicarboxylic aciduria (HP:0003215)1.76176094
73Abnormality of urine glucose concentration (HP:0011016)1.73223054
74Glycosuria (HP:0003076)1.73223054
75Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.72512630
76Abnormality of the heme biosynthetic pathway (HP:0010472)1.72327739
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.71844971
78Abnormal biliary tract morphology (HP:0012440)1.71170141
79Abnormality of macular pigmentation (HP:0008002)1.70511902
80Optic nerve hypoplasia (HP:0000609)1.70018302
81Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69541359
82Neoplasm of head and neck (HP:0012288)1.68213935
83Esophageal neoplasm (HP:0100751)1.68213935
84Recurrent sinusitis (HP:0011108)1.67850052
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67106843
86Abnormal mitochondria in muscle tissue (HP:0008316)1.66848263
87Stenosis of the external auditory canal (HP:0000402)1.64419359
88Sclerocornea (HP:0000647)1.64299311
89Abnormality of chromosome stability (HP:0003220)1.62955369
90Lymphangioma (HP:0100764)1.62789328
91Abnormality of vitamin B metabolism (HP:0004340)1.62152056
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.60632610
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.60058690
94Volvulus (HP:0002580)1.58452051
95Meningioma (HP:0002858)1.58311695
96Gonadotropin excess (HP:0000837)1.57079890
97Long nose (HP:0003189)1.56672364
98Lip pit (HP:0100267)1.55669222
99Calf muscle hypertrophy (HP:0008981)1.55203182
100Asplenia (HP:0001746)1.52736446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.55077793
2FRK6.53974566
3TAF13.84814567
4CDK192.90254877
5NUAK12.46069006
6GRK12.25893155
7VRK22.09710492
8MARK11.95890175
9CASK1.85660968
10MATK1.85312931
11ADRBK21.74752842
12KIT1.71719527
13AKT31.67625050
14FGFR21.64926469
15MAP4K21.64610353
16BMPR1B1.61015393
17TNIK1.55690639
18TAOK31.44096589
19PIK3CG1.42918599
20PLK41.38739142
21EIF2AK11.33254796
22INSRR1.32805547
23PRKG21.26521660
24NEK21.26161923
25MAP3K131.20252009
26CAMK1D1.18498251
27OXSR11.18320155
28VRK11.15947903
29CAMK1G1.14547045
30EIF2AK31.11791771
31CHEK21.10149505
32PRKD21.03638929
33ZAK1.03355326
34PINK11.02054393
35DAPK21.00344033
36CSNK1G30.91818832
37DAPK10.82239971
38PLK20.81767432
39JAK30.79823923
40BUB10.78303820
41MAPKAPK50.77014592
42CSNK1G20.76306858
43WNK30.76215055
44GRK50.75316355
45PLK30.75012060
46ILK0.74050269
47CSNK1G10.72108996
48TRPM70.68188704
49RPS6KB10.67622747
50STK390.66165103
51FLT30.66113379
52MAP3K40.65211696
53ACVR1B0.63870244
54CSNK1A1L0.60331112
55SGK20.60308257
56PRKCQ0.57081171
57WNK40.56452408
58PLK10.53116849
59NTRK30.51776434
60MST40.50720870
61FGFR30.49851240
62CDC70.49509185
63DAPK30.49412901
64MAP2K30.48877860
65IRAK40.48068240
66CDK90.47105844
67TEC0.45835323
68ADRBK10.45180589
69MAP3K30.42875819
70ATM0.42710149
71MAPK40.42594337
72PRKCH0.42580114
73EIF2AK20.42117384
74PBK0.41933125
75TXK0.40843833
76MAP2K10.40674587
77RPS6KA60.39847027
78SMG10.39118352
79IRAK10.37669888
80CAMK10.36919024
81PRKCZ0.36460440
82RPS6KA50.36351095
83PRKG10.35819105
84PRKCE0.35381037
85MAP2K60.34011420
86TIE10.33553624
87CSNK2A20.33354949
88PRKCA0.33326615
89NTRK20.33208100
90AURKA0.33204616
91MAPK130.31403714
92PRKACA0.30120935
93ERBB30.29430041
94TLK10.28755185
95PRKACG0.28426641
96OBSCN0.28323101
97PNCK0.27018821
98STK30.26991900
99PRKCI0.26861519
100STK110.26274697

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.47431611
2Sulfur metabolism_Homo sapiens_hsa009203.34276855
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.95372633
4Homologous recombination_Homo sapiens_hsa034402.91331368
5Olfactory transduction_Homo sapiens_hsa047402.66799521
6Linoleic acid metabolism_Homo sapiens_hsa005912.59618830
7Basal transcription factors_Homo sapiens_hsa030222.54867733
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.43564802
9Arachidonic acid metabolism_Homo sapiens_hsa005902.40031726
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25547492
11Ribosome_Homo sapiens_hsa030102.18409941
12Propanoate metabolism_Homo sapiens_hsa006402.14088227
13Chemical carcinogenesis_Homo sapiens_hsa052041.96876969
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91923177
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91453009
16Ether lipid metabolism_Homo sapiens_hsa005651.73948136
17Oxidative phosphorylation_Homo sapiens_hsa001901.71848624
18Butanoate metabolism_Homo sapiens_hsa006501.71803329
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70631664
20Fanconi anemia pathway_Homo sapiens_hsa034601.66442341
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64809715
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61085640
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56618150
24Sulfur relay system_Homo sapiens_hsa041221.55831356
25Retinol metabolism_Homo sapiens_hsa008301.54557023
26Fat digestion and absorption_Homo sapiens_hsa049751.51003355
27beta-Alanine metabolism_Homo sapiens_hsa004101.41846600
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38135958
29One carbon pool by folate_Homo sapiens_hsa006701.37456507
30Phototransduction_Homo sapiens_hsa047441.34651402
31Parkinsons disease_Homo sapiens_hsa050121.33728623
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.32480542
33Fatty acid degradation_Homo sapiens_hsa000711.32355928
34Peroxisome_Homo sapiens_hsa041461.28580966
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25736440
36Nitrogen metabolism_Homo sapiens_hsa009101.23612878
37Asthma_Homo sapiens_hsa053101.22687973
38RNA polymerase_Homo sapiens_hsa030201.22478894
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.19977070
40Tryptophan metabolism_Homo sapiens_hsa003801.11372186
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06091764
42Taste transduction_Homo sapiens_hsa047421.05274496
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04697717
44Protein export_Homo sapiens_hsa030600.98642747
45Renin secretion_Homo sapiens_hsa049240.94822902
46Fatty acid metabolism_Homo sapiens_hsa012120.93221912
47Nicotine addiction_Homo sapiens_hsa050330.92691671
48Caffeine metabolism_Homo sapiens_hsa002320.92336545
49RNA transport_Homo sapiens_hsa030130.92103982
50RNA degradation_Homo sapiens_hsa030180.87854315
51Melanoma_Homo sapiens_hsa052180.86939433
52Alzheimers disease_Homo sapiens_hsa050100.86442738
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80803422
54PPAR signaling pathway_Homo sapiens_hsa033200.77040991
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76639491
56Huntingtons disease_Homo sapiens_hsa050160.75131092
57Glutathione metabolism_Homo sapiens_hsa004800.73664887
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72250437
59Folate biosynthesis_Homo sapiens_hsa007900.69649750
60p53 signaling pathway_Homo sapiens_hsa041150.67433626
61ABC transporters_Homo sapiens_hsa020100.65027397
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.64817410
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64648041
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62631392
65Morphine addiction_Homo sapiens_hsa050320.59258953
66Salivary secretion_Homo sapiens_hsa049700.57646979
67Circadian entrainment_Homo sapiens_hsa047130.57037713
68Sphingolipid metabolism_Homo sapiens_hsa006000.57030734
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55864967
70Insulin secretion_Homo sapiens_hsa049110.55362166
71Nucleotide excision repair_Homo sapiens_hsa034200.54959168
72Serotonergic synapse_Homo sapiens_hsa047260.53998952
73Calcium signaling pathway_Homo sapiens_hsa040200.53026962
74Metabolic pathways_Homo sapiens_hsa011000.51122005
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.51079099
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.48672426
77Mismatch repair_Homo sapiens_hsa034300.48111988
78Cardiac muscle contraction_Homo sapiens_hsa042600.47001920
79DNA replication_Homo sapiens_hsa030300.45933020
80Proteasome_Homo sapiens_hsa030500.44279262
81Long-term depression_Homo sapiens_hsa047300.43091753
82Oocyte meiosis_Homo sapiens_hsa041140.42405091
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.42018523
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40887573
85Tyrosine metabolism_Homo sapiens_hsa003500.40397584
86N-Glycan biosynthesis_Homo sapiens_hsa005100.40148022
87Glycerolipid metabolism_Homo sapiens_hsa005610.38188943
88Purine metabolism_Homo sapiens_hsa002300.35432910
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34733535
90Hematopoietic cell lineage_Homo sapiens_hsa046400.31891310
91Ovarian steroidogenesis_Homo sapiens_hsa049130.30479945
92Primary immunodeficiency_Homo sapiens_hsa053400.29812604
93Pancreatic secretion_Homo sapiens_hsa049720.29146220
94Glutamatergic synapse_Homo sapiens_hsa047240.29097706
95Vitamin digestion and absorption_Homo sapiens_hsa049770.28997210
96TGF-beta signaling pathway_Homo sapiens_hsa043500.28276743
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28255119
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27706134
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27130440
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.25665316

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